nipecotic acid has been researched along with gamma-aminobutyric acid in 202 studies
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 69 (34.16) | 18.7374 |
| 1990's | 78 (38.61) | 18.2507 |
| 2000's | 37 (18.32) | 29.6817 |
| 2010's | 16 (7.92) | 24.3611 |
| 2020's | 2 (0.99) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, FE; Bondinell, WE; Dandridge, PA; Frazee, JS; Garvey, E; Girard, GR; Kaiser, C; Ku, TW; Lafferty, JJ; Moonsammy, GI | 1 |
| Fleischhacker, W; Müller-Uri, C; Singer, EA | 1 |
| Enna, SJ; Patch, RJ; Tomita, K; Witiak, DT | 1 |
| Atkinson, JG; Girard, Y; Haubrich, DR; Williams, M; Yarbrough, GG | 1 |
| Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Labouta, IM; Schaumburg, K | 1 |
| Borden, LA; Branchek, TA; Dhar, TG; Gluchowski, C; Smith, KE; Tyagarajan, S; Weinshank, RL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bray, SM; Chang, S; He, C; Jin, P; Li, Z; Warren, ST; Zarnescu, DC | 1 |
| Giralt, E; Malakoutikhah, M; Prades, R; Teixidó, M | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Lutz, TA; Petrera, M; Sindelar, M; Wanner, KT | 1 |
| Höfner, G; Quandt, G; Wanner, KT | 1 |
| Kern, F; Wanner, KT | 1 |
| Cowey, A; Kritzer, MF; Somogyi, P | 1 |
| Nicoll, RA; Solís, JM | 1 |
| Lambert, JD; Roepstorff, A | 1 |
| Black, JA; Kocsis, JD; Sakatani, K | 1 |
| Deakin, JF; Royston, MC; Simpson, MD; Slater, P | 1 |
| Freschi, JE; Kerrison, J | 1 |
| Cardinali, DP; González Burgos, G; Rosenstein, RE | 1 |
| Brahce, L; Gregor, VE; Lobbestael, SJ; Mayhugh, DR; Nugiel, D; Pavia, MR; Schwarz, RD; Taylor, CP; Vartanian, MG | 1 |
| Keithley, EM; Ryan, AF; Schwartz, IR; Wang, ZX | 1 |
| Anderson, GM; Craig, JS; During, MJ; Gallager, DW; Hernandez, TD | 1 |
| Masland, RH; O'Malley, DM; Sandell, JH | 1 |
| Dutia, MB; Johnston, AR; McQueen, DS | 1 |
| Barolet, AW; Morris, ME | 1 |
| Ching, W; Hassan, AZ; Sakatani, K | 1 |
| Gallo, V; Levi, G; Patrizio, M | 1 |
| Bourdelais, A; Kalivas, PW | 1 |
| Balcar, VJ | 1 |
| Gordon-Weeks, PR; Taylor, J | 1 |
| Andrioli, GC; Bonanno, G; Raiteri, M; Ruelle, A | 1 |
| Czudek, C; Reynolds, GP | 1 |
| Brehm, L; Krogsgaard-Larsen, P; Nielsen, L | 1 |
| Ayer, DE; Blakeman, DP; Davis, JP; Im, WB | 1 |
| Andrews, HB; Czudek, C; Reynolds, GP | 1 |
| Blakeman, DP; Davis, JP; Im, WB | 1 |
| Sved, AF; Sved, JC | 2 |
| Malchow, RP; Ripps, H | 1 |
| Bernardi, G; Calabresi, P; De Murtas, M; Mercuri, NB | 1 |
| Anderson, JJ; DiMicco, JA | 1 |
| Boismare, F; Daoust, M; Lhuintre, JP; Moore, N; Saligaut, C | 1 |
| Dingledine, R; Korn, SJ | 1 |
| Armstrong, WE; Sladek, CD | 1 |
| Schwartz, EA | 1 |
| Bockaert, J; Pin, JP; Yasumoto, T | 1 |
| Bonanno, G; Fedele, E; Fontana, G; Raiteri, M; Robino, G | 1 |
| Arakawa, T; Okada, Y | 2 |
| Althaus, JS; Martin, DL | 1 |
| Georgiev, V; Kambourova, T; Yonkov, D | 1 |
| Giuliani, S; Maggi, CA; Meli, A; Santicioli, P; Selleri, S | 1 |
| Deakin, JF; Royston, MC; Simpson, MD; Skan, WJ; Slater, P | 1 |
| Goldin, SM; Turner, TJ | 1 |
| Dutar, P; Lamour, Y; Rascol, O | 1 |
| Hasser, EM; Haywood, JR; Segura, T; Shade, RE | 1 |
| Cross, AJ; Deakin, JF; Simpson, MD; Slater, P | 1 |
| Brennan, TJ; Haywood, JR; Hinojosa, C | 1 |
| del Rio, RM; Herreras, O; Lerma, J | 1 |
| Shepherd, D; Tyrer, NM | 1 |
| Nicholson, RA; Strang, RH; Whitton, PS | 1 |
| Bockaert, J; Pin, JP | 1 |
| Beitz, AJ; Larson, AA | 1 |
| Dalkara, T | 1 |
| Ciesielski, L; Gobaille, S; Mandel, P; Molina, V | 1 |
| Hertz, L; Larsson, OM; Schousboe, A | 1 |
| Lindgren, S; Simmonds, MA | 1 |
| Forni, C; Halsey, MJ; Rostain, JC; Wardley-Smith, B | 1 |
| Debeljuk, L; Díaz, MC; Duvilanski, BH; Lasaga, M; Seilicovich, A | 1 |
| Catelli, JM; Sved, AF | 1 |
| Bernath, S; Zigmond, MJ | 1 |
| Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A | 1 |
| Kehr, J; Ungerstedt, U | 1 |
| Kihara, M; Kubo, T | 1 |
| Debeljuk, L; del Carmen Diaz, M; Duvilanski, BH; Lasaga, M; Seilicovich, A | 1 |
| Dennis, BJ; Kerr, DI; Krantis, A | 1 |
| Ryan, AF; Schwartz, IR | 1 |
| Catelli, JM; Giakas, WJ; Sved, AF | 1 |
| Yazulla, S | 1 |
| Hambley, JW; Johnston, GA | 1 |
| Cañadas Correas, S; González González, MP; Massó Córdoba, JM; Oset Gasque, MJ | 1 |
| Limberger, N; Späth, L; Starke, K | 1 |
| Fredholm, BB; Jonzon, B | 1 |
| Brennan, TJ; Haywood, JR | 1 |
| Hablitz, JJ; Lebeda, FJ | 1 |
| Deisz, RA; Dose, M; Lux, HD | 1 |
| Lloyd, KG; Pilc, A | 1 |
| Classen, K; Göthert, M; Schlicker, E | 1 |
| Brown, DA; Scholfield, CN | 1 |
| Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A; Thorbek, P | 1 |
| Madtes, P; Redburn, DA | 1 |
| Madtes, PC; Redburn, DA | 1 |
| Deisz, RA; Dose, M | 1 |
| Hernández, N; Holder, LG; Jaffé, EH | 1 |
| Moonsammy, GI; Rush, JA; Yunger, LM | 1 |
| Atkinson, HD; Little, HJ | 1 |
| Cherubini, E; North, RA | 1 |
| Horton, RW; Prestwich, SA; Spyrou, NA | 1 |
| del Rio, RM; Herranz, AS; Herreras, O; Lerma, J; Munoz, D | 1 |
| Bendahan, A; Kanner, BI; Radian, R | 1 |
| Drejer, J; Hertz, L; Larsson, OM; Schousboe, A | 1 |
| Szerb, JC | 1 |
| Giacobini, E; Nomura, Y; Okuma, Y; Schmidt-Glenewinkel, T; Segawa, T | 1 |
| Kovalev, GI; Raevskiĭ, KS | 1 |
| Larsson, OM; Schousboe, A | 1 |
| Copenhagen, DR; Kaneko, A; Miyoshi, S; Takahashi, K | 1 |
| Bindi, D; Franchi-Micheli, S; Gentilini, G; Mugnai, S; Zilletti, L | 1 |
| Brechtel, C; Fleming, SR; King, SC | 1 |
| Gill, SS; Mbungu, D; Ross, LS | 1 |
| Desmonts, JM; Henzel, D; Lecharny, JB; Mantz, J; Salord, F | 1 |
| Honmou, O; Kocsis, JD; Richerson, GB | 1 |
| Desmonts, JM; Henzel, D; Laudenbach, V; Lecharny, JB; Mantz, J; Peytavin, G | 1 |
| Sharp, T; Smith, SE | 1 |
| Ijaz, S; Kanthan, R; Mainprize, T; Miyashita, H; Shuaib, A | 1 |
| Honmou, O; Kocsis, JD | 1 |
| Koga, T; Osawa, I; Saito, N; Tanaka, C | 1 |
| Björklund, A; Campbell, K; Kalén, P; Lundberg, C; Mandel, RJ; Wictorin, K | 1 |
| Aihara, N; Koide, K; Mabe, H; Mizukawa, K; Nishino, H | 1 |
| Chesler, M; Hassan, AZ; Lee, M; Sakatani, K; Young, W | 1 |
| Horvitz, HR; Jorgensen, E; McIntire, SL | 1 |
| Björklund, A; Campbell, K; Kalén, P; Lundberg, C; Rosengren, E; Wictorin, K | 1 |
| Kocsis, JD; Lim, JY; Sakatani, K; Utzschneider, DA | 1 |
| el Manira, A; Grillner, S; Matsushima, T; Tegnér, J | 1 |
| Malchow, RP; Qian, H; Ripps, H | 1 |
| Liu, QR; López-Corcuera, B; Mandiyan, S; Nelson, H; Nelson, N | 1 |
| Lloyd, KG; Thuret, F; Vargas, F | 1 |
| Andersen, KE; Braestrup, C; Grønwald, FC; Jørgensen, AS; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD; Sørensen, PO | 1 |
| Honmou, O; Kocsis, JD; Oyelese, AA | 1 |
| Del Zotto, H; Etchegoyen, GS | 1 |
| Ijaz, S; Kalra, J; Kanthan, R; Mainprize, T; Miyashita, H; Shuaib, A | 1 |
| Horii, A; Mochizuki, T; Okakura-Mochizuki, K; Yamamoto, Y; Yamatodani, A | 1 |
| Brotchie, JM; Crossman, AR; Maneuf, YP | 1 |
| Draguhn, A; Heinemann, U; Meierkord, H; Pfeiffer, M | 1 |
| Chen, DZ; Katsura, M; Kuriyama, K; Narihara, H; Ohkuma, S | 1 |
| Hashimoto, T; Kuriyama, K | 1 |
| Kolachana, BS; Saunders, RC; Weinberger, DR | 1 |
| Egebjerg, J; Sørensen, PO; Thomsen, C | 1 |
| Kelley, AE; Stratford, TR | 1 |
| Dobolyi, A; Juhász, G; Kékesi, KA; Krogsgaard-Larsen, P; Nyitrai, G; Schousboe, A | 1 |
| Nicklas, WJ; Zeevalk, GD | 1 |
| Agulian, S; Kocsis, JD; Yee, JM | 1 |
| Abraini, JH; Bouquet, C; Cagniard, B; Kriem, B; Rostain, JC | 1 |
| Castañeda, TR; Del Arco, A; Mora, F | 1 |
| Crook, JM; Eysel, UT; Kisvárday, ZF | 1 |
| Cherubini, E; Martina, M; Sciancalepore, M; Strata, F | 1 |
| Hemmings, HC; Murugaiah, KD | 1 |
| Falch, E; Frølund, BF; Krogsgaard-Larsen, P | 1 |
| Georgiev, V; Hadjiivanova, CH | 1 |
| Goshima, Y; Honjo, K; Misu, Y; Miyamae, T | 1 |
| Landmesser, LT; Milner, LD | 1 |
| Arias-Montaño, JA; Bahena-Trujillo, R | 1 |
| Del Arco, A; Galindo, A; Mora, F | 1 |
| Reith, CA; Sillar, KT | 1 |
| Bouma, M; Davis, M; De Vries, JB; Timmerman, W; Westerink, BH | 1 |
| Frydenvang, K; Frølund, B; Krogsgaard-Larsen, P | 1 |
| Köfalvi, A; Sperlágh, B; Vizi, ES; Zelles, T | 1 |
| Bernard, LP; Nicklas, WJ; Stokes, AH; Zeevalk, GD | 1 |
| Mac, M; Nałecz, KA; Nałecz, MJ; Sacher, A; Wawrzeńczyk, A | 1 |
| Patrylo, PR; Spencer, DD; Williamson, A | 1 |
| Richerson, GB; Wang, W; Wu, Y | 1 |
| Auer, M; Gownley, C; Kim, MJ; Li, XD; Song, J; Villa, A; Wang, DN | 1 |
| Barrett-Jolley, R | 1 |
| Kakee, A; Naito, M; Sugiyama, Y; Takanaga, H; Terasaki, T; Tsuruo, T | 1 |
| Scholze, P; Singer, EA; Sitte, HH | 1 |
| Himmelreich, NH; Linetska, MV; Storchak, LG | 1 |
| Al-Hayani, A; Davies, SN | 1 |
| König, N; Poluch, S | 1 |
| Ferreira, M; Gillis, RA; Hernandez, YM; Sahibzada, N; Wasserman, AM | 1 |
| Maruyama, K; Nakamura, S; Nishina, M; Suzuki, M | 1 |
| Brown-Istvan, L; King, SC | 1 |
| Himmelreich, NH; Linetska, MV; Storchak, LG; Tarasenko, AS | 1 |
| Isogai, O; Ito, S; Masubuchi, Y; Saito, S; Tsukamoto, K; Uchiyama, T; Yajima, Y | 1 |
| King, SC | 1 |
| Eldred, WD; Yu, D | 1 |
| Hablitz, JJ; Keros, S | 1 |
| Cremers, TI; Rea, K; Westerink, BH | 1 |
| Akaike, A; Katsuki, H | 1 |
| Alachkar, A; Brotchie, J; Jones, OT | 1 |
| Bongianni, F; Mutolo, D; Nardone, F; Pantaleo, T | 1 |
| Galik, J; Hefferan, MP; Kakinohana, M; Kakinohana, O; Marsala, J; Marsala, M; Nakamura, S; Tomori, Z; Yaksh, TL | 1 |
| Fujimori, S; Hinoi, E; Iemata, M; Takahata, Y; Takarada, T; Yoneda, Y | 1 |
| Baghdoyan, HA; Lydic, R; Watson, CJ | 1 |
| Marino, V; Nassery, K; Parker, DA | 1 |
| Fang, K; Lin, G; Liu, X; Zhang, J; Zhang, P | 1 |
| De Mello, FG; De Mello, MC; De Melo Reis, RA; De Sampaio Schitine, C; Kubrusly, RC; Yamasaki, EN | 1 |
| Asgari, A; Ghani, E; Ghasemi, A; Khoshbaten, A; Mohammadi, M | 1 |
| Dadarlat, M; Hassell, T; Irazoqui, P; Jedlicka, SS; Lin, Y; Rickus, JL; Young, A; Zhang, M | 1 |
| Gao, H; Smith, BN | 1 |
| Aguilar, MB; Díaz-Muñoz, M; Giordano, M; Márquez-Ramos, JA; Mejía-Toiber, J; Peña, F | 1 |
| Darnall, RA; Schneider, RW; Tobia, CM; Zemel, BM | 1 |
| David, L; Jørgensen, FS; Skovstrup, S; Taboureau, O | 1 |
| Arranz-Gibert, P; Giralt, E; Guixer, B; Malakoutikhah, M; Teixidó, M | 1 |
| Baghdoyan, HA; Lydic, R; Nemanis, K; Vanini, G | 1 |
| Akanuma, S; Hosoya, K; Kubo, Y; Tachikawa, M; Yahara, T | 1 |
| Holm, R; Lagunas, C; Nielsen, CU; Plum, J; Rasmussen, RN | 1 |
| Gonzales, RA; Zandy, SL | 1 |
| Dine, J; Eder, M; Höfner, G; Lutz, T; Pabel, J; Wanner, KT; Wein, T | 1 |
| Höfner, G; Tóth, K; Wanner, KT | 1 |
| Bassi, S; Catalano, M; Conti, F; Fattorini, G; Limatola, C; Melone, M; Serpe, C | 1 |
| Akhtar, MJ; Bhatia, R; Kumar, B; Kumar, P; Mehta, V; Singh, K | 1 |
| Dörnyei, G; Gács-Baitz, E; Héja, L; Incze, M; Kardos, J; Kovács, I; Peredy-Kajtár, M; Szántay, C; Szárics, E; Temesváriné-Major, E | 1 |
3 review(s) available for nipecotic acid and gamma-aminobutyric acid
| Article | Year |
|---|---|
Neurohumoral mechanisms of sodium-dependent hypertension.
Topics: Animals; Arginine Vasopressin; Diet, Sodium-Restricted; gamma-Aminobutyric Acid; Humans; Hypertension; Hypertension, Renal; Neurotransmitter Agents; Nipecotic Acids; Proline; Saline Solution, Hypertonic; Sodium | 1985 |
GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood-Brain Barrier; Drug Design; gamma-Aminobutyric Acid; Humans; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Prodrugs; Proline; Structure-Activity Relationship | 2000 |
Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies.
Topics: Anticonvulsants; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine | 2022 |
199 other study(ies) available for nipecotic acid and gamma-aminobutyric acid
| Article | Year |
|---|---|
Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Topics: 4-Aminobutyrate Transaminase; Administration, Oral; Alkylation; Amino Acids; Animals; Brain; Carboxylic Acids; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1985 |
Synthesis of alkyl-substituted arecoline derivatives as gamma-aminobutyric acid uptake inhibitors.
Topics: Animals; Arecoline; Binding, Competitive; Brain; Cerebellum; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Kinetics; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains; Synaptosomes | 1986 |
Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; In Vitro Techniques; Molecular Conformation; Quinolines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism; Synaptosomes | 1981 |
Aminomethyl-1,2,4-benzothiadiazines as potential analogues of gamma-aminobutyric acid. Unexpected discovery of a taurine antagonist.
Topics: 4-Aminobutyrate Transaminase; Animals; Benzothiadiazines; Brain; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes; Taurine | 1982 |
Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; In Vitro Techniques; Magnetic Resonance Spectroscopy; Molecular Conformation; Piperidines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes; Synaptosomes | 1982 |
Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3.
Topics: Animals; Binding Sites; Biological Transport; Blood-Brain Barrier; Carrier Proteins; Cell Line; Cloning, Molecular; Drug Design; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Ligands; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Proline; Rats | 1994 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
Topics: Animals; Disease Models, Animal; Drosophila; Drosophila Proteins; Drug Evaluation, Preclinical; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Male; Molecular Weight; Mutation; Phenotype; Pyridines; RNA, Messenger; Small Molecule Libraries | 2008 |
N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Biological Transport; Blood Vessels; Blood-Brain Barrier; Brain; Cattle; Cell Membrane Permeability; Cells, Cultured; Chromatography, High Pressure Liquid; Coculture Techniques; Drug Carriers; Endothelial Cells; gamma-Aminobutyric Acid; Mass Spectrometry; Molecular Structure; Nipecotic Acids; Oligopeptides; Phenylalanine; Rats | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
Topics: GABA Plasma Membrane Transport Proteins; Hydrazones; Mass Spectrometry | 2013 |
Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.
Topics: Animals; Anticonvulsants; Biological Transport; Cell Membrane; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Mice; Neuroprotective Agents; Nipecotic Acids; Structure-Activity Relationship; Vinyl Compounds | 2013 |
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1.
Topics: Binding Sites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; HEK293 Cells; Humans; Mass Spectrometry; Molecular Structure; N-Acetylglucosaminyltransferases; Oximes; Small Molecule Libraries; Structure-Activity Relationship | 2019 |
Patterns of inter- and intralaminar GABAergic connections distinguish striate (V1) and extrastriate (V2, V4) visual cortices and their functionally specialized subdivisions in the rhesus monkey.
Topics: Animals; Autoradiography; Electron Transport Complex IV; gamma-Aminobutyric Acid; Macaca mulatta; Microinjections; Neural Pathways; Neurons; Nipecotic Acids; Proline; Tritium; Visual Cortex | 1992 |
Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus.
Topics: Animals; Carrier Proteins; Electrodes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Nipecotic Acids; Organophosphorus Compounds; Picrotoxin; Proline; Pyramidal Tracts; Rats; Synapses; Tetrodotoxin | 1992 |
Comparison of the effect of the GABA uptake blockers, tiagabine and nipecotic acid, on inhibitory synaptic efficacy in hippocampal CA1 neurones.
Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurons; Nipecotic Acids; Proline; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Tiagabine | 1992 |
Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve.
Topics: Action Potentials; Animals; Animals, Newborn; gamma-Aminobutyric Acid; Immunohistochemistry; Membrane Potentials; Nipecotic Acids; Optic Nerve; Proline; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1992 |
Regionally selective deficits in uptake sites for glutamate and gamma-aminobutyric acid in the basal ganglia in schizophrenia.
Topics: Aspartic Acid; Brain; Caudate Nucleus; Dominance, Cerebral; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Glutamic Acid; Humans; Nipecotic Acids; Nucleus Accumbens; Proline; Putamen; Radioligand Assay; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Schizophrenia; Schizophrenic Psychology | 1992 |
The effects of gamma-aminobutyric acid on voltage-clamped motoneurons of the lobster cardiac ganglion.
Topics: Animals; Chlorides; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; gamma-Aminobutyric Acid; Ganglia; Membrane Potentials; Motor Neurons; Nephropidae; Nipecotic Acids; Picrotoxin; Proline; Receptors, GABA-A; Sodium | 1992 |
Neurochemical evidence for a neuronal GABAergic system in the rat sympathetic superior cervical ganglion.
Topics: Acetanilides; Anesthetics, Local; Animals; beta-Alanine; Brain Chemistry; Calcium; Female; gamma-Aminobutyric Acid; Ganglia, Sympathetic; Kinetics; Male; Neurons; Neurotransmitter Agents; Nipecotic Acids; Proline; Rats; Rats, Wistar; Receptors, GABA-A; Veratrine | 1992 |
Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.
Topics: Administration, Oral; Animals; Anticonvulsants; Benzhydryl Compounds; Blood-Brain Barrier; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Mice; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Proline; Rats; Structure-Activity Relationship | 1992 |
Selective retrograde transport of nipecotic acid, a GABA analog, labels a subpopulation of gerbil olivocochlear neurons.
Topics: Animals; Autoradiography; Biological Transport; Cochlea; gamma-Aminobutyric Acid; Gerbillinae; Horseradish Peroxidase; Microscopy, Electron; Neural Pathways; Neurons, Efferent; Nipecotic Acids; Olivary Nucleus; Perfusion; Proline; Sensitivity and Specificity; Tritium | 1992 |
Effect of amygdala kindling on the in vivo release of GABA and 5-HT in the dorsal raphe nucleus in freely moving rats.
Topics: Amino Acids; Amygdala; Animals; Dialysis; Fluoxetine; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Nipecotic Acids; Potassium; Proline; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Tetrodotoxin; Veratridine | 1992 |
Co-release of acetylcholine and GABA by the starburst amacrine cells.
Topics: Acetylcholine; Animals; Autoradiography; Drug Carriers; GABA Antagonists; gamma-Aminobutyric Acid; Nipecotic Acids; Proline; Retina | 1992 |
Tonic activity of rat medial vestibular nucleus neurones in vitro and its inhibition by GABA.
Topics: Action Potentials; Animals; Baclofen; Cobalt; Dose-Response Relationship, Drug; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Neurons; Nipecotic Acids; Picrotoxin; Proline; Rats; Rats, Inbred Strains; Vestibular Nuclei | 1992 |
Changes in extracellular K+ evoked by GABA, THIP and baclofen in the guinea-pig hippocampal slice.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Electrodes; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Isoxazoles; Nipecotic Acids; Potassium; Proline; Receptors, GABA-A; Temperature | 1991 |
Age-dependent extrasynaptic modulation of axonal conduction by exogenous and endogenous GABA in the rat optic nerve.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Axons; Cells, Cultured; gamma-Aminobutyric Acid; Isonicotinic Acids; Neural Conduction; Nipecotic Acids; Optic Nerve; Proline; Rats; Receptors, GABA-A; Synapses | 1991 |
GABA release triggered by the activation of neuron-like non-NMDA receptors in cultured type 2 astrocytes is carrier-mediated.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Carrier Proteins; Cells, Cultured; Cerebellum; Chlorides; Cyclic GMP; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Lithium; Lithium Chloride; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Nipecotic Acids; Nitroprusside; Organic Anion Transporters; Proline; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Secretory Rate; Sodium; Stimulation, Chemical | 1991 |
High sensitivity HPLC assay for GABA in brain dialysis studies.
Topics: Acetonitriles; Amino Acids; Amino Acids, Neutral; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dialysis; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Microchemistry; Nipecotic Acids; Oxidation-Reduction; Proline; Rats | 1991 |
Presence of a highly efficient "binding" to bacterial contamination can distort data from binding studies.
Topics: Animals; Cats; Cerebral Cortex; GABA Antagonists; gamma-Aminobutyric Acid; Gram-Positive Bacteria; Isonicotinic Acids; Muscimol; Nipecotic Acids; Proline; Pyridazines; Radioligand Assay; Receptors, GABA-A; Tritium | 1990 |
Calcium-independent gamma-aminobutyric acid release from growth cones: role of gamma-aminobutyric acid transport.
Topics: Animals; Biological Transport; Calcium; Carrier Proteins; Cell Membrane; Diencephalon; Female; gamma-Aminobutyric Acid; Male; Neurons; Nipecotic Acids; Potassium; Proline; Rats; Rats, Inbred Strains; Synaptosomes; Telencephalon | 1991 |
Cholinergic nerve terminals of human cerebral cortex possess a GABA transporter whose activation induces release of acetylcholine.
Topics: Acetylcholine; Anticonvulsants; Baclofen; Bicuculline; Biotransformation; Carrier Proteins; Cerebral Cortex; Choline; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Muscimol; Nerve Endings; Nerve Tissue Proteins; Nipecotic Acids; Organic Anion Transporters; Parasympathetic Nervous System; Proline; Synaptosomes | 1991 |
[3H]nipecotic acid binding to gamma-aminobutyric acid uptake sites in postmortem human brain.
Topics: Aged; Aging; Binding Sites; Brain; Cadaver; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; Huntington Disease; Male; Middle Aged; Nipecotic Acids; Postmortem Changes; Proline; Sodium; Tritium | 1990 |
GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-beta-proline.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hydrogen Bonding; Male; Molecular Conformation; Molecular Structure; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes; Synaptosomes; X-Ray Diffraction | 1990 |
Studies on the mechanism of interactions between anesthetic steroids and gamma-aminobutyric acidA receptors.
Topics: Anesthetics; Animals; Chlorides; Desoxycorticosterone; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Nipecotic Acids; Pentobarbital; Pregnanolone; Progesterone; Proline; Rats; Receptors, GABA-A; Synaptic Membranes | 1990 |
Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia.
Topics: Aged; Aged, 80 and over; Amygdala; Dominance, Cerebral; Dopamine; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Middle Aged; Nipecotic Acids; Proline; Receptors, Dopamine; Receptors, GABA-A; Schizophrenia; Schizophrenic Psychology; Temporal Lobe | 1990 |
Na(+)-dependent GABA transport system scavenges endogenous external GABA and prevents desensitization of GABAA receptors in rat cerebrocortical synaptoneurosomes.
Topics: Animals; Cerebral Cortex; Chlorides; gamma-Aminobutyric Acid; Male; Muscimol; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sodium; Synaptosomes | 1990 |
Endogenous GABA acts on GABAB receptors in nucleus tractus solitarius to increase blood pressure.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Baclofen; Blood Pressure; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Medulla Oblongata; Muscimol; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vigabatrin | 1990 |
Effects of gamma-aminobutyric acid on skate retinal horizontal cells: evidence for an electrogenic uptake mechanism.
Topics: Animals; Bicuculline; Biological Transport, Active; Electric Conductivity; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Nipecotic Acids; Picrotoxin; Proline; Retina; Skates, Fish; Sodium | 1990 |
Endogenous GABA mediates presynaptic inhibition of spontaneous and evoked excitatory synaptic potentials in the rat neostriatum.
Topics: Animals; Baclofen; Corpus Striatum; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Synapses; Tetrodotoxin | 1990 |
Effect of local inhibition of gamma-aminobutyric acid uptake in the dorsomedial hypothalamus on extracellular levels of gamma-aminobutyric acid and on stress-induced tachycardia: a study using microdialysis.
Topics: Amino Acids; Animals; Blood Pressure; Dialysis; Extracellular Space; gamma-Aminobutyric Acid; Heart Rate; Hypothalamus, Middle; Male; Nipecotic Acids; Potassium; Proline; Rats; Rats, Inbred Strains; Stress, Physiological; Tachycardia | 1990 |
Alcohol and GABA: ethanol intake modifies hippocampal nipecotic acid binding in ethanol-preferring and non-preferring rats.
Topics: Animals; Ethanol; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Proline; Rats; Self Administration | 1990 |
Gamma-aminobutyric acid uptake and the termination of inhibitory synaptic potentials in the rat hippocampal slice.
Topics: Action Potentials; Animals; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channels; Kinetics; Male; Models, Biological; Neurons; Nipecotic Acids; Pentobarbital; Proline; Rats; Rats, Inbred Strains; Synapses | 1985 |
gamma-Aminobutyric acid antagonists stimulate vasopressin release from organ-cultured hypothalamo-neurohypophyseal explants.
Topics: Acetylcholine; Animals; Bacitracin; Bicuculline; Chlorides; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Ion Channels; Male; Nipecotic Acids; Organ Culture Techniques; Osmolar Concentration; Penicillins; Picrotoxin; Pituitary Gland, Posterior; Proline; Rats; Rats, Inbred Strains; Vasopressins | 1987 |
Depolarization without calcium can release gamma-aminobutyric acid from a retinal neuron.
Topics: Animals; Benzofurans; Calcium; Catfishes; Cell Communication; Cell Membrane; Cells, Cultured; Chlorides; Egtazic Acid; Electrophysiology; Fluorescent Dyes; Fura-2; gamma-Aminobutyric Acid; Ion Channels; Neurons; Nipecotic Acids; Photoreceptor Cells; Proline; Retina; Synapses | 1987 |
Maitotoxin-evoked gamma-aminobutyric acid release is due not only to the opening of calcium channels.
Topics: Amino Acids; Animals; Calcium; Cells, Cultured; Cobalt; Corpus Striatum; Embryo, Mammalian; gamma-Aminobutyric Acid; Ion Channels; Marine Toxins; Mice; Neurons; Nifedipine; Nipecotic Acids; Oxocins; Proline; Sodium; Tetrodotoxin | 1988 |
Presynaptic mechanisms underlying the gamma-aminobutyric acid-evoked receptor-independent release of [3H]norepinephrine in rat hippocampus.
Topics: Animals; Biomechanical Phenomena; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Norepinephrine; Proline; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Sodium; Synapses; Tetrodotoxin; Tritium | 1989 |
Cardiovascular responses elicited by gamma-aminobutyric acid in the nucleus tractus solitarius: evidence for action at the GABAB receptor.
Topics: Animals; Baclofen; Bicuculline; Blood Pressure; gamma-Aminobutyric Acid; Hemodynamics; Injections; Male; Medulla Oblongata; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vasopressins | 1989 |
The effect of GABA on neurotransmission in frog tectal slices.
Topics: Action Potentials; Animals; Electric Stimulation; gamma-Aminobutyric Acid; In Vitro Techniques; Nipecotic Acids; Proline; Rana catesbeiana; Superior Colliculi; Synaptic Transmission | 1989 |
Entropy as a factor in the binding of gamma-aminobutyric acid and nipecotic acid to the gamma-aminobutyric acid transport system.
Topics: Animals; Binding Sites; Brain Chemistry; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Molecular Conformation; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes; Temperature; Thermodynamics | 1989 |
Further evidence for the GABAergic influence on memory. Interaction of GABAergic transmission with angiotensin II on memory processes.
Topics: Angiotensin II; Animals; Avoidance Learning; Bicuculline; gamma-Aminobutyric Acid; Male; Memory; Muscimol; Nipecotic Acids; Picrotoxin; Proline; Rats; Rats, Inbred Strains; Synaptic Transmission | 1989 |
The motor response to ethylenediamine of the rat isolated duodenum: involvement of GABAergic transmission?
Topics: 3-Mercaptopropionic Acid; Animals; Benzalkonium Compounds; Duodenum; Ethylenediamines; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nipecotic Acids; Picrotoxin; Proline; Rats; Rats, Inbred Strains; Synaptic Transmission; Tetrodotoxin | 1989 |
Reduced GABA uptake sites in the temporal lobe in schizophrenia.
Topics: Amygdala; Cerebral Cortex; Functional Laterality; gamma-Aminobutyric Acid; Hippocampus; Humans; Middle Aged; Nipecotic Acids; Proline; Schizophrenia; Temporal Lobe | 1989 |
Multiple components of synaptosomal [3H]-gamma-aminobutyric acid release resolved by a rapid superfusion system.
Topics: Animals; Brain; Cadmium; Calcium; gamma-Aminobutyric Acid; Kinetics; Male; Nickel; Nipecotic Acids; Proline; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Sodium; Synaptosomes; Tritium | 1989 |
Rhythmical bursting activity and GABAergic mechanisms in the medial septum of normal and pertussis toxin-pretreated rats.
Topics: Action Potentials; Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Hippocampus; Male; Neurons; Nipecotic Acids; Pertussis Toxin; Proline; Rats; Rats, Inbred Strains; Septum Pellucidum; Virulence Factors, Bordetella | 1989 |
Evidence of an endogenous forebrain GABAergic system capable of inhibiting baroreceptor-mediated vasopressin release.
Topics: Animals; Arginine Vasopressin; Frontal Lobe; gamma-Aminobutyric Acid; Male; Nipecotic Acids; Pressoreceptors; Proline; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Loss of cortical GABA uptake sites in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Proline; Receptors, GABA-A | 1988 |
Excitatory and inhibitory action of GABA on synaptic transmission in slices of guinea pig superior colliculus.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Muscimol; Nipecotic Acids; Perfusion; Proline; Receptors, GABA-A; Superior Colliculi; Synaptic Membranes; Synaptic Transmission | 1988 |
Electrophysiological evidence that nipecotic acid can be used in vivo as a false transmitter.
Topics: Animals; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Synaptic Transmission | 1985 |
Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle.
Topics: Aminobutyrates; Animals; beta-Alanine; Female; GABA Antagonists; gamma-Aminobutyric Acid; Grasshoppers; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscles; Nipecotic Acids; Proline | 1985 |
Effect of taurine on neurotransmitter release from insect synaptosomes.
Topics: Acetylcholine; Animals; Choline; gamma-Aminobutyric Acid; Grasshoppers; Neurotransmitter Agents; Nipecotic Acids; Potassium; Proline; Synaptosomes; Taurine; Veratridine | 1988 |
Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture.
Topics: Amino Acids; Animals; Biomechanical Phenomena; Calcium; Cells, Cultured; Chlorides; Corpus Striatum; Fetus; gamma-Aminobutyric Acid; Lithium; Mice; Mice, Inbred Strains; Neuroglia; Neurons; Nipecotic Acids; Proline; Second Messenger Systems; Tetanus Toxin; Veratridine | 1989 |
Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Injections, Spinal; Male; Mice; Nipecotic Acids; Picrotoxin; Pipecolic Acids; Proline; Receptors, GABA-A; Seizures; Strychnine | 1985 |
Nipecotic acid, an uptake blocker, prevents fading of the gamma-aminobutyric acid effect.
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Hippocampus; Male; Muscimol; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior.
Topics: Aggression; Aminocaproates; Animals; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Male; Motor Activity; Muscimol; Nipecotic Acids; Olfactory Bulb; Proline; Rats; Rats, Inbred Strains; Synaptic Transmission; Valproic Acid; Vigabatrin | 1986 |
Uptake of GABA and nipecotic acid in astrocytes and neurons in primary cultures: changes in the sodium coupling ratio during differentiation.
Topics: Animals; Astrocytes; Biological Transport; Bucladesine; Cell Differentiation; Cells, Cultured; gamma-Aminobutyric Acid; Kinetics; Mathematics; Mice; Neurons; Nipecotic Acids; Proline; Sodium | 1986 |
Adaptation of the GABAA-receptor complex in rat brain during chronic elevation of GABA by ethanolamine O-sulphate.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain Chemistry; Ethanolamines; Flurazepam; gamma-Aminobutyric Acid; Muscimol; Nipecotic Acids; Pentobarbital; Picrotoxin; Potassium; Proline; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Gamma-aminobutyric acid and the high pressure neurological syndrome.
Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Central Nervous System Diseases; Electrodes, Implanted; Electroencephalography; gamma-Aminobutyric Acid; High Pressure Neurological Syndrome; Male; Myoclonus; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Tremor; Valproic Acid | 1986 |
Effect of ethanol on GABA uptake and release from hypothalamic fragments.
Topics: Animals; Calcium; Ethanol; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamus; Male; Nipecotic Acids; Potassium; Proline; Radioligand Assay; Rats; Rats, Inbred Strains | 1988 |
Enhanced pressor response to GABA in the nucleus tractus solitarii of the spontaneously hypertensive rat.
Topics: Animals; Baclofen; Blood Pressure; Brain Stem; gamma-Aminobutyric Acid; Heart Rate; Hypertension; Male; Muscimol; Nipecotic Acids; Proline; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1988 |
Characterization of [3H]GABA release from striatal slices: evidence for a calcium-independent process via the GABA uptake system.
Topics: Animals; Calcium; Corpus Striatum; Electric Stimulation; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Tetrodotoxin | 1988 |
Kinetic characterization of inhibition of gamma-aminobutyric acid uptake into cultured neurons and astrocytes by 4,4-diphenyl-3-butenyl derivatives of nipecotic acid and guvacine.
Topics: Animals; Anticonvulsants; Astrocytes; Cells, Cultured; Cerebral Cortex; Chemical Phenomena; Chemistry; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Neurons; Nicotinic Acids; Nipecotic Acids; Proline | 1988 |
Fast HPLC estimation of gamma-aminobutyric acid in microdialysis perfusates: effect of nipecotic and 3-mercaptopropionic acids.
Topics: 3-Mercaptopropionic Acid; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Extracellular Space; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1988 |
Studies on GABAergic mechanisms responsible for cardiovascular regulation in the rostral ventrolateral medulla of the rat.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; gamma-Aminobutyric Acid; Hemodynamics; Male; Medulla Oblongata; Microinjections; Nipecotic Acids; Pressoreceptors; Proline; Rats; Rats, Inbred Strains; Veratrine | 1987 |
Mechanisms of endogenous GABA release from hypothalamic fragments. Effect of prolactin.
Topics: 3-Mercaptopropionic Acid; Animals; Arcuate Nucleus of Hypothalamus; Calcium; Culture Techniques; gamma-Aminobutyric Acid; Hypothalamus; Male; Median Eminence; Nipecotic Acids; Paraventricular Hypothalamic Nucleus; Potassium; Prolactin; Proline; Rats; Rats, Inbred Strains | 1987 |
Autoradiographic study of the distribution of [3H]gamma-aminobutyrate-accumulating neural elements in guinea-pig intestine: evidence for a transmitter function of gamma-aminobutyrate.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Aminobutyrates; Animals; Autoradiography; Colon; Cyclohexanecarboxylic Acids; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; Leucine; Male; Myenteric Plexus; Neurons; Nipecotic Acids; Paraffin; Proline | 1986 |
Nipecotic acid: preferential accumulation in the cochlea by GABA uptake systems and selective retrograde transport to brainstem.
Topics: Animals; Autoradiography; Biological Transport, Active; Brain Stem; Cochlea; Efferent Pathways; gamma-Aminobutyric Acid; Gerbillinae; Neurons, Efferent; Nipecotic Acids; Olivary Nucleus; Proline; Time Factors | 1986 |
GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release.
Topics: Animals; Bicuculline; Blood Pressure; gamma-Aminobutyric Acid; Heart Rate; Male; Medulla Oblongata; Muscimol; Nipecotic Acids; Pressoreceptors; Proline; Rats; Rats, Inbred Strains; Vasopressins | 1987 |
Factors controlling the release of GABA from goldfish retinal horizontal cells.
Topics: Animals; Calcium; Cyprinidae; Dopamine; gamma-Aminobutyric Acid; Goldfish; In Vitro Techniques; Light; Mitochondria; Neurons; Nipecotic Acids; Proline; Retina; Sodium | 1985 |
Uptake of gamma-aminobutyric acid by human blood platelets: comparison with CNS uptake.
Topics: Amino Acids; Amino Acids, Cyclic; beta-Alanine; Blood Platelets; Central Nervous System; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Humans; Kinetics; Nipecotic Acids; Proline; Sodium; Taurine | 1985 |
Uptake of GABA by bovine adrenal medulla slices.
Topics: Adrenal Medulla; Aminobutyrates; Animals; beta-Alanine; Cattle; gamma-Aminobutyric Acid; Glucose; Kinetics; Nipecotic Acids; Potassium; Proline; Sodium; Time Factors | 1985 |
Release of previously incorporated gamma-[3H]aminobutyric acid in rabbit caudate nucleus slices.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Calcium; Caudate Nucleus; Cyclohexanecarboxylic Acids; Electric Stimulation; Female; gamma-Aminobutyric Acid; Male; Nipecotic Acids; Proline; Rabbits; Tetrodotoxin; Tritium | 1986 |
Release of purines, noradrenaline, and GABA from rat hippocampal slices by field stimulation.
Topics: Adenine; Aminooxyacetic Acid; Animals; Dipyridamole; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Norepinephrine; Potassium; Proline; Purines; Rats; Rats, Inbred Strains | 1985 |
GABAergic inhibition of hypertonic saline-induced vasopressin-dependent hypertension.
Topics: Aminobutyrates; Animals; Blood Pressure; gamma-Aminobutyric Acid; Heart Rate; Male; Nephrectomy; Nipecotic Acids; Osmolar Concentration; Proline; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Sodium; Sympathetic Nervous System; Vasopressins | 1985 |
Role of uptake in gamma-aminobutyric acid (GABA)-mediated responses in guinea pig hippocampal neurons.
Topics: Animals; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Iontophoresis; Male; Membrane Potentials; Neural Inhibition; Neurons; Nipecotic Acids; Proline; Synapses | 1985 |
The time course of GABA action on the crayfish stretch receptor: evidence for a saturable GABA uptake.
Topics: Animals; Astacoidea; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Mechanoreceptors; Membrane Potentials; Muscle, Smooth; Neural Inhibition; Nipecotic Acids; Proline; Receptors, Cell Surface; Receptors, GABA-A; Synapses; Synaptic Transmission; Vas Deferens | 1984 |
Chronic antidepressants and GABA "B" receptors: a GABA hypothesis of antidepressant drug action.
Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Desipramine; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Pargyline; Proline; Propylamines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Viloxazine | 1984 |
GABAB receptor-mediated inhibition of serotonin release in the rat brain.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Brain Chemistry; Cerebral Cortex; Diazepam; Electric Stimulation; gamma-Aminobutyric Acid; Hydroxyindoleacetic Acid; In Vitro Techniques; Male; Nipecotic Acids; Phentolamine; Picrotoxin; Proline; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Serotonin | 1984 |
Inhibition of GABA uptake potentiates the conductance increase produced by GABA-mimetic compounds on single neurones in isolated olfactory cortex slices of the guinea-pig.
Topics: Animals; Central Nervous System; Cerebral Cortex; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Isonicotinic Acids; Muscimol; Neural Conduction; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Olfactory Pathways; Proline; Sodium; Taurine | 1984 |
Effect of homo-beta-proline and other heterocyclic GABA analogues on GABA uptake in neurons and astroglial cells and on GABA receptor binding.
Topics: Animals; Animals, Newborn; Astrocytes; Biological Transport; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred Strains; Neurons; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Structure-Activity Relationship | 1981 |
GABA as a trophic factor during development.
Topics: Animals; Animals, Newborn; gamma-Aminobutyric Acid; Isoxazoles; Muscimol; Nipecotic Acids; Proline; Rabbits; Receptors, Cell Surface; Receptors, GABA-A; Retina | 1983 |
Synaptic interactions in the GABA system during postnatal development in retina.
Topics: Animals; Cell Differentiation; gamma-Aminobutyric Acid; Muscimol; Nipecotic Acids; Proline; Rabbits; Receptors, Cell Surface; Receptors, GABA-A; Retina; Synaptic Transmission | 1983 |
Comparison of GABA analogues at the crayfish stretch receptor neurone.
Topics: Animals; Astacoidea; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Isoxazoles; Mechanoreceptors; Membrane Potentials; Muscimol; Nipecotic Acids; Proline; Sodium | 1983 |
Study of the mechanism of release of [3H]GABA from a teleost retina in vitro.
Topics: Alanine; Animals; Calcium; Calcium Channel Blockers; Fishes; gamma-Aminobutyric Acid; Nipecotic Acids; Potassium; Proline; Retina; Sodium; Tetrodotoxin; Veratridine | 1984 |
Kinetic analysis of the accumulation of gamma-aminobutyric acid by particulate fractions of rat brain: comparison of the effects of nipecotic acid and cis-3-aminocyclohexane-1-carboxylic acid.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Brain; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Kinetics; Male; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Tritium | 1983 |
Ketamine potentiates the responses of the rat superior cervical ganglion to GABA.
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Ganglia, Spinal; Ketamine; Male; Nicotinic Acids; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Taurine | 1984 |
Actions of gamma-aminobutyric acid on neurones of guinea-pig myenteric plexus.
Topics: Acetylcholine; Alanine; Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Glycine; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscimol; Myenteric Plexus; Neural Conduction; Neuromuscular Depolarizing Agents; Neurons; Nipecotic Acids; Picrotoxin; Proline; Tetrodotoxin | 1984 |
Synaptosomal [3H]GABA uptake and [3H]nipecotic acid binding in audiogenic seizure susceptible (DBA/2) and resistant (C57 B1/6) mice.
Topics: Acoustic Stimulation; Age Factors; Animals; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nipecotic Acids; Pons; Proline; Seizures; Synaptosomes | 1984 |
In vivo effects of nipecotic acid on levels of extracellular GABA and taurine, and hippocampal excitability.
Topics: Animals; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Nipecotic Acids; Proline; Rats; Rats, Inbred Strains; Taurine | 1984 |
Efflux and exchange of gamma-aminobutyric acid and nipecotic acid catalysed by synaptic plasma membrane vesicles isolated from immature rat brain.
Topics: Animals; Brain; Chlorides; Female; gamma-Aminobutyric Acid; Kinetics; Nigericin; Nipecotic Acids; Proline; Rats; Sodium; Synaptic Membranes | 1983 |
Ion dependency of uptake and release of GABA and (RS)-nipecotic acid studied in cultured mouse brain cortex neurons.
Topics: Animals; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; gamma-Aminobutyric Acid; Kinetics; Mice; Neurons; Nipecotic Acids; Proline; Sodium | 1983 |
Effect of nipecotic acid, a gamma-aminobutyric acid transport inhibitor, on the turnover and release of gamma-aminobutyric acid in rat cortical slices.
Topics: Animals; Calcium; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Magnesium; Nipecotic Acids; Potassium; Proline; Rats; Tetrodotoxin; Tritium | 1982 |
Comparison of synaptosomal and glial uptake of pipecolic acid and GABA in rat brain.
Topics: Animals; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neuroglia; Nipecotic Acids; Pipecolic Acids; Potassium; Proline; Rats; Synaptosomes | 1981 |
[Nipecotic acid, a competitive inhibitor of the net uptake of 3H-GABA by rat brain synaptosomes].
Topics: Absorption; Animals; Cerebral Cortex; Depression, Chemical; gamma-Aminobutyric Acid; In Vitro Techniques; Nipecotic Acids; Proline; Rats; Synaptosomes | 1981 |
Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: coupling with two sodium ions.
Topics: Animals; Astrocytes; Biological Transport; gamma-Aminobutyric Acid; Kinetics; Mice; Nipecotic Acids; Proline; Sodium | 1981 |
Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina.
Topics: Animals; Anticonvulsants; Carrier Proteins; Catfishes; Dose-Response Relationship, Drug; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Proline; Retina | 1995 |
GABA-mediated inhibition of the anaphylactic response in the guinea-pig trachea.
Topics: Anaphylaxis; Animals; beta-Alanine; Bronchial Hyperreactivity; Capsaicin; Drug Interactions; Epithelial Cells; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Histamine Release; Macrophage Activation; Macrophages, Alveolar; Male; Mast Cells; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Nipecotic Acids; Ovalbumin; Platelet Activating Factor; Proline; Receptors, GABA; Tetrodotoxin; Trachea | 1995 |
Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP.
Topics: Biological Transport; Escherichia coli; Escherichia coli Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Genes, Bacterial; Membrane Transport Modulators; Membrane Transport Proteins; Nicotinic Acids; Nipecotic Acids; Organic Anion Transporters; Piperidines; Proline; Substrate Specificity | 1995 |
Cloning, functional expression, and pharmacology of a GABA transporter from Manduca sexta.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; DNA Primers; Embryo, Nonmammalian; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Gene Library; Kinetics; Manduca; Membrane Proteins; Membrane Transport Proteins; Mice; Molecular Sequence Data; Nipecotic Acids; Oocytes; Organic Anion Transporters; Polymerase Chain Reaction; Proline; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis | 1995 |
Effects of thiopental, halothane and isoflurane on the calcium-dependent and -independent release of GABA from striatal synaptosomes in the rat.
Topics: Anesthetics; Animals; Calcium; Corpus Striatum; gamma-Aminobutyric Acid; Halothane; Isoflurane; Male; Membrane Potentials; Nipecotic Acids; Proline; Rats; Rats, Sprague-Dawley; Synaptosomes; Thiopental; Veratridine | 1995 |
Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Synergism; Electric Conductivity; Gabapentin; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Nipecotic Acids; Patch-Clamp Techniques; Proline; Pyramidal Cells; Rats; Rats, Wistar | 1995 |
Anesthetics affect the uptake but not the depolarization-evoked release of GABA in rat striatal synaptosomes.
Topics: Anesthetics; Animals; Biological Transport; Clonidine; Corpus Striatum; Enflurane; Etomidate; gamma-Aminobutyric Acid; Halothane; In Vitro Techniques; Isoflurane; Ketamine; Male; Nipecotic Acids; Potassium Chloride; Proline; Propofol; Rats; Rats, Sprague-Dawley; Synaptosomes; Thiopental | 1995 |
An investigation of the origin of extracellular GABA in rat nucleus accumbens measured in vivo by microdialysis.
Topics: 3-Mercaptopropionic Acid; Animals; Calcium; Chromatography, High Pressure Liquid; Electrochemistry; Extracellular Space; GABA Antagonists; gamma-Aminobutyric Acid; Magnesium; Male; Microdialysis; Nipecotic Acids; Nucleus Accumbens; Potassium; Proline; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1994 |
Progressive decrease in extracellular GABA concentrations in the post-ischemic period in the striatum: a microdialysis study.
Topics: Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Extracellular Space; gamma-Aminobutyric Acid; Gerbillinae; Glutamic Acid; Microdialysis; Neostriatum; Nipecotic Acids; Proline; Substantia Nigra | 1994 |
Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve.
Topics: Acetates; Action Potentials; Amines; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cyclohexanecarboxylic Acids; GABA-A Receptor Antagonists; Gabapentin; gamma-Aminobutyric Acid; Membrane Potentials; Neuromuscular Depolarizing Agents; Nipecotic Acids; Optic Nerve; Proline; Rats; Rats, Wistar; Receptors, GABA-A | 1994 |
Phorbol ester-induced inhibition of GABA uptake by synaptosomes and by Xenopus oocytes expressing GABA transporter (GAT1).
Topics: Alkaloids; Animals; Base Sequence; Brain; Carrier Proteins; Cerebral Cortex; DNA, Complementary; Female; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Library; Kinetics; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Nipecotic Acids; Oligonucleotide Probes; Oocytes; Organic Anion Transporters; Proline; Protein Kinase C; Rats; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate; Xenopus | 1994 |
Characterization of GABA release from intrastriatal striatal transplants: dependence on host-derived afferents.
Topics: Animals; Brain Tissue Transplantation; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Female; Fetal Tissue Transplantation; gamma-Aminobutyric Acid; Ibotenic Acid; Immunohistochemistry; Kainic Acid; Neurons, Afferent; Nipecotic Acids; Oxidopamine; Potassium Chloride; Proline; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Tyrosine 3-Monooxygenase | 1993 |
Striatal grafts in infarct striatopallidum increase GABA release, reorganize GABAA receptor and improve water-maze learning in the rat.
Topics: Animals; Autoradiography; Brain Ischemia; Brain Tissue Transplantation; Cell Transplantation; Cerebral Arteries; Cerebral Infarction; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Learning; Male; Microdialysis; Neostriatum; Nipecotic Acids; Proline; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A | 1994 |
Non-synaptic modulation of dorsal column conduction by endogenous GABA in neonatal rat spinal cord.
Topics: Action Potentials; Animals; Animals, Newborn; Axons; gamma-Aminobutyric Acid; Neural Conduction; Nipecotic Acids; Proline; Rats; Receptors, GABA-A; Spinal Cord; Synapses | 1993 |
Genes required for GABA function in Caenorhabditis elegans.
Topics: Animals; Behavior, Animal; Caenorhabditis elegans; Cell Differentiation; gamma-Aminobutyric Acid; Genes, Helminth; Muscimol; Mutation; Neurons; Nipecotic Acids; Proline | 1993 |
Extracellular gamma-aminobutyric acid levels in the rat caudate-putamen: monitoring the neuronal and glial contribution by intracerebral microdialysis.
Topics: Animals; Calcium; Caudate Nucleus; Chromatography, High Pressure Liquid; Dialysis; Electrochemistry; Extracellular Space; Female; gamma-Aminobutyric Acid; Ibotenic Acid; Neuroglia; Neurons; Nipecotic Acids; Potassium Chloride; Proline; Putamen; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Veratridine | 1993 |
The attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve.
Topics: Action Potentials; Aging; Animals; Bicuculline; gamma-Aminobutyric Acid; In Vitro Techniques; Muscimol; Myelin Sheath; Nipecotic Acids; Optic Nerve; Proline; Rats; Rats, Mutant Strains; Receptors, GABA-A; Reference Values | 1993 |
The spinal GABA system modulates burst frequency and intersegmental coordination in the lamprey: differential effects of GABAA and GABAB receptors.
Topics: Animals; Baclofen; Bicuculline; Culture Techniques; Diazepam; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Lampreys; Locomotion; Motor Neurons; Muscimol; Muscles; N-Methylaspartate; Nerve Net; Neurons; Nipecotic Acids; Proline; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1993 |
The effects of lowered extracellular sodium on gamma-aminobutyric acid (GABA)-induced currents of Muller (glial) cells of the skate retina.
Topics: Animals; Cells, Cultured; Chloride Channels; Extracellular Space; gamma-Aminobutyric Acid; Ion Channel Gating; Membrane Potentials; Membrane Proteins; Neuroglia; Nipecotic Acids; Proline; Receptors, GABA-A; Signal Transduction; Skates, Fish; Sodium | 1993 |
Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].
Topics: Amino Acid Sequence; Animals; Base Sequence; beta-Alanine; Betaine; Biological Transport; Brain; Brain Chemistry; Carrier Proteins; Cloning, Molecular; DNA; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Membrane Proteins; Membrane Transport Proteins; Mice; Molecular Sequence Data; Nipecotic Acids; Oocytes; Organ Specificity; Organic Anion Transporters; Proline; RNA, Messenger; Taurine; Xenopus | 1993 |
Characterization of the nipecotic binding to rat brain membranes.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Nipecotic Acids; Proline; Rats; Rats, Sprague-Dawley; Sodium | 1993 |
The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Topics: Animals; Anticonvulsants; GABA Antagonists; gamma-Aminobutyric Acid; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Proline; Prosencephalon; Rats; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Tiagabine | 1993 |
The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Electrophysiology; Extracellular Space; Female; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Microinjections; Nipecotic Acids; Proline; Pyramidal Cells; Rats; Rats, Wistar | 1995 |
Effect of catecholestrogens on [3H]-GABA uptake by hypothalamic crude synaptosomes.
Topics: Animals; Estradiol; Estrogens, Catechol; Estrone; Female; gamma-Aminobutyric Acid; Hydroxyestrones; Hypothalamus; In Vitro Techniques; Nipecotic Acids; Proline; Rats; Rats, Sprague-Dawley; Synaptosomes; Tritium | 1995 |
GABA concentrations in the striatum following repetitive cerebral ischemia.
Topics: Animals; Corpus Striatum; Drug Synergism; gamma-Aminobutyric Acid; Gerbillinae; Ischemic Attack, Transient; Male; Membrane Potentials; Microdialysis; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Potassium Chloride; Proline; Recurrence | 1995 |
Endogenous GABA modulates histamine release from the anterior hypothalamus of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Histamine Release; Hypothalamus, Anterior; Male; Microdialysis; Neurons; Nipecotic Acids; Picrotoxin; Presynaptic Terminals; Proline; Rats; Rats, Wistar | 1996 |
Modulation of GABAergic transmission in the globus pallidus by the synthetic cannabinoid WIN 55,212-2.
Topics: Analgesics; Animals; Benzoxazines; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Globus Pallidus; Male; Morpholines; Naphthalenes; Nipecotic Acids; Proline; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Entorhinal Cortex; Epilepsy; Female; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; Muscimol; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Proline; Rats; Rats, Wistar; Tiagabine | 1996 |
Nitric oxide-evoked [3H] gamma-aminobutyric acid release is mediated by two distinct release mechanisms.
Topics: Animals; Biological Transport; Calcium; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Mice; Neurons; Nipecotic Acids; Nitric Oxide; Nitroprusside; Oximes; Penicillamine; Proline; S-Nitroso-N-Acetylpenicillamine; Sodium; Tritium | 1996 |
GABAA receptor-mediated K(+)-evoked GABA release from globus pallidus--analysis using microdialysis.
Topics: Animals; Baclofen; Dinucleoside Phosphates; GABA Agonists; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; Muscimol; Nipecotic Acids; Potassium Chloride; Proline; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
In vivo characterization of extracellular GABA release in the caudate nucleus and prefrontal cortex of the rhesus monkey.
Topics: Animals; Calcium; Caudate Nucleus; Cerebrospinal Fluid; GABA Agents; gamma-Aminobutyric Acid; Infusions, Parenteral; Macaca mulatta; Membrane Potentials; Microdialysis; Nipecotic Acids; Potassium; Prefrontal Cortex; Proline; Tetrodotoxin; Veratridine | 1997 |
1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
Topics: Animals; Carrier Proteins; Cell Line; Cricetinae; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Piperidines; Proline; Tiagabine | 1997 |
GABA in the nucleus accumbens shell participates in the central regulation of feeding behavior.
Topics: Animals; Baclofen; Eating; Enzyme Inhibitors; Feeding Behavior; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Microinjections; Muscimol; Nipecotic Acids; Nucleus Accumbens; Proline; Rats; Rats, Sprague-Dawley; Vigabatrin | 1997 |
Differential effects of nipecotic acid and 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol on extracellular gamma-aminobutyrate levels in rat thalamus.
Topics: Animals; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Extracellular Space; gamma-Aminobutyric Acid; Isoxazoles; Microdialysis; Nipecotic Acids; Proline; Rats; Rats, Wistar; Thalamus | 1997 |
Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Chick Embryo; Culture Techniques; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycolysis; Iodoacetates; Ischemia; Isoxazoles; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nipecotic Acids; Organic Anion Transporters; Oximes; Proline; Retina | 1997 |
Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Axons; Bicuculline; Carrier Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Models, Neurological; Nipecotic Acids; Optic Nerve; Organic Anion Transporters; Potassium Chloride; Proline; Rats; Rats, Wistar; Receptors, GABA-A; Time Factors; Vigabatrin | 1998 |
Modulation by GABA transmission in the substantia nigra compacta and reticulata of locomotor activity in rats exposed to high pressure.
Topics: Animals; Baclofen; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Helium; High Pressure Neurological Syndrome; Male; Motor Activity; Muscimol; Myoclonus; Nipecotic Acids; Proline; Rats; Rats, Sprague-Dawley; Receptors, GABA; Substantia Nigra; Synaptic Transmission; Time Factors; Vigabatrin | 1998 |
Amphetamine releases GABA in striatum of the freely moving rat: involvement of calcium and high affinity transporter mechanisms.
Topics: Amphetamine; Animals; Calcium; Carrier Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Membrane Proteins; Membrane Transport Proteins; Microdialysis; Neostriatum; Nipecotic Acids; Organic Anion Transporters; Proline; Rats; Rats, Wistar | 1998 |
Evidence for a contribution of lateral inhibition to orientation tuning and direction selectivity in cat visual cortex: reversible inactivation of functionally characterized sites combined with neuroanatomical tracing techniques.
Topics: Animals; Cats; Functional Laterality; gamma-Aminobutyric Acid; Iontophoresis; Lysine; Neural Inhibition; Neurons; Nipecotic Acids; Orientation; Proline; Synaptic Transmission; Visual Cortex | 1998 |
GABA excites immature CA3 pyramidal cells through bicuculline-sensitive and -insensitive chloride-dependent receptors.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Chloride Channels; Culture Techniques; Evoked Potentials; gamma-Aminobutyric Acid; Kynurenic Acid; Nipecotic Acids; Patch-Clamp Techniques; Picrotoxin; Proline; Pyramidal Cells; Rats; Receptors, GABA-A; Receptors, GABA-B; Zinc | 1998 |
Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes.
Topics: Aminobutyrates; Anesthesia, General; Anesthetics, Intravenous; Animals; Baclofen; Bicuculline; Calcium; Cerebral Cortex; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Nerve Endings; Nipecotic Acids; Picrotoxin; Potassium Chloride; Proline; Propofol; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Synaptic Transmission; Synaptosomes; Tritium | 1998 |
Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents.
Topics: Animals; Brain; Carrier Proteins; Cloning, Molecular; Drug Design; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Molecular Structure; Muscimol; Neuroglia; Neurons; Nipecotic Acids; Organic Anion Transporters; Proline; Radioligand Assay; Recombinant Proteins; Tritium | 1998 |
In vitro effect of angiotensin II on GABA release in rat hippocampus.
Topics: Angiotensin II; Animals; Calcium; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Magnesium; Male; Nipecotic Acids; Potassium Chloride; Proline; Rats; Rats, Wistar | 1998 |
GABA may function tonically via GABA(A) receptors to inhibit hypotension and bradycardia by L-DOPA microinjected into depressor sites of the nucleus tractus solitarii in anesthetized rats.
Topics: Anesthesia; Animals; Bicuculline; Binding, Competitive; Bradycardia; Dopamine Agents; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Hypotension; Levodopa; Male; Microinjections; Nipecotic Acids; Pressoreceptors; Proline; Rats; Rats, Wistar; Receptors, GABA-A; Solitary Nucleus; Tritium | 1999 |
Cholinergic and GABAergic inputs drive patterned spontaneous motoneuron activity before target contact.
Topics: Acetylcholine; Action Potentials; Animals; Bicuculline; Chick Embryo; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Motor Neurons; Neuromuscular Junction; Nipecotic Acids; Proline; Receptors, Nicotinic; Synaptic Transmission | 1999 |
[3H] gamma-aminobutyric acid transport in rat substantia nigra pars reticulata synaptosomes: pharmacological characterization and phorbol ester-induced inhibition.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Basal Ganglia; beta-Alanine; Biological Transport; Carcinogens; Colforsin; Enzyme Inhibitors; GABA Agents; gamma-Aminobutyric Acid; Nipecotic Acids; Proline; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Substantia Nigra; Synaptosomes; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Endogenous GABA potentiates the potassium-induced release of dopamine in striatum of the freely moving rat: a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Homovanillic Acid; Male; Microdialysis; Models, Neurological; Motor Activity; Nipecotic Acids; Potassium; Proline; Rats; Rats, Wistar; Substantia Nigra; Tetrodotoxin | 1999 |
Development and role of GABA(A) receptor-mediated synaptic potentials during swimming in postembryonic Xenopus laevis tadpoles.
Topics: Animals; Bicuculline; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glycine Agents; Larva; Neurons; Nipecotic Acids; Pregnanolone; Proline; Receptors, GABA-A; Rhombencephalon; Spinal Cord; Strychnine; Swimming; Synapses; Xenopus laevis | 1999 |
A microdialysis study on the mechanism of action of gabapentin.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Nipecotic Acids; Potassium; Proline; Rats; Rats, Wistar; Substantia Nigra | 2000 |
Long-lasting facilitation of 4-amino-n-[2,3-(3)H]butyric acid ([(3)H]GABA) release from rat hippocampal slices by nicotinic receptor activation.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Atropine; Calcium; Carrier Proteins; Chloride Channels; Drug Synergism; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Proteins; Membrane Transport Proteins; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nipecotic Acids; Organic Anion Transporters; Perfusion; Proline; Protein Kinase C; Rats; Rats, Wistar; Receptors, Nicotinic; Sodium Channel Blockers; Tritium | 2000 |
Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.
Topics: Animals; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Malonates; Mesencephalon; Muscimol; Neurons; Nipecotic Acids; Oximes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
Transport of L-carnitine in isolated cerebral cortex neurons.
Topics: Animals; beta-Alanine; Betaine; Binding, Competitive; Biological Transport, Active; Carnitine; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Neurons; Nipecotic Acids; Oocytes; Organic Anion Transporters; Organic Cation Transport Proteins; Oximes; Rats; Rats, Wistar; Solute Carrier Family 22 Member 5; Taurine; Xenopus laevis | 2001 |
GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.
Topics: Animals; Biological Transport; Carrier Proteins; Dentate Gyrus; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Reference Values; Sclerosis; Temporal Lobe | 2001 |
GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter.
Topics: 4-Aminobutyrate Transaminase; Animals; Calcium; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Membrane Proteins; Membrane Transport Proteins; Neural Inhibition; Neurons; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Potassium; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Vigabatrin | 2001 |
Monomeric state and ligand binding of recombinant GABA transporter from Escherichia coli.
Topics: Bacterial Proteins; Carrier Proteins; Detergents; Escherichia coli; Escherichia coli Proteins; Fluorescence; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Ligands; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nipecotic Acids; Organic Anion Transporters; Protein Binding; Protein Structure, Quaternary; Recombinant Fusion Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thrombin | 2001 |
Nipecotic acid directly activates GABA(A)-like ion channels.
Topics: Animals; Bicuculline; Chloride Channels; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Membrane Potentials; Neurons; Nipecotic Acids; Paraventricular Hypothalamic Nucleus; Rats; Receptors, GABA-A | 2001 |
Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier.
Topics: Animals; beta-Alanine; Biological Transport; Blood-Brain Barrier; Brain; Capillaries; Carrier Proteins; Cell Line; Endothelium, Vascular; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Half-Life; Kinetics; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Microinjections; Nipecotic Acids; Organic Anion Transporters; Parietal Lobe; Probenecid; Rats; Rats, Sprague-Dawley; Taurine; Tritium | 2001 |
Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1.
Topics: Aminobutyrates; Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Humans; Kidney; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Ouabain; Rats; Receptors, GABA; Tiagabine; Tritium | 2002 |
Does extracellular calcium determine what pool of GABA is the target for alpha-latrotoxin?
Topics: Aminobutyrates; Animals; Calcium; Cell Membrane; Cytosol; Electrophysiology; Extracellular Space; gamma-Aminobutyric Acid; Male; Neurotoxins; Nipecotic Acids; Rats; Rats, Wistar; Spider Venoms; Synaptosomes | 2002 |
Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent.
Topics: Animals; Benzoxazines; Cannabinoids; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Morpholines; Naphthalenes; Nicotinic Acids; Nipecotic Acids; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Synaptic Transmission; Temperature | 2002 |
AMPA receptor activation induces GABA release from neurons migrating tangentially in the intermediate zone of embryonic rat neocortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Carrier Proteins; Cell Differentiation; Cell Movement; Excitatory Amino Acid Antagonists; Female; Fetus; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Immunohistochemistry; Membrane Proteins; Membrane Transport Proteins; Microtubule-Associated Proteins; Neocortex; Neurons; Nipecotic Acids; Organic Anion Transporters; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Stem Cells; Synaptic Transmission | 2002 |
GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat.
Topics: Animals; Apnea; Baclofen; Bicuculline; Cardiovascular System; Fluorescent Antibody Technique; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Kynurenic Acid; Male; Microinjections; Muscimol; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Receptors, GABA; Respiration; Synaptic Transmission; Ventral Thalamic Nuclei | 2002 |
Endogenous GABA in the commissural subnucleus of the NTS inhibits the carotid chemoreceptor reflex via GABA A receptors in rats.
Topics: Animals; Blood Pressure; Carotid Arteries; Chemoreceptor Cells; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heart Rate; Male; Neural Inhibition; Nipecotic Acids; Rats; Rats, Wistar; Receptors, GABA-A; Solitary Nucleus | 2003 |
Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP.
Topics: Amino Acid Sequence; Biological Transport; Carrier Proteins; Consensus Sequence; Cysteine; Escherichia coli Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hydrophobic and Hydrophilic Interactions; Isopropyl Thiogalactoside; Kinetics; Membrane Proteins; Membrane Transport Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nipecotic Acids; Organic Anion Transporters; Protein Structure, Secondary; Substrate Specificity | 2003 |
Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release.
Topics: Algorithms; Animals; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carrier Proteins; Cell Membrane; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Ionophores; Macrolides; Male; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Oximes; Rats; Rats, Wistar; Spider Venoms; Stimulation, Chemical; Synaptic Transmission; Synaptosomes | 2004 |
Effect of a high-salt diet on gamma-aminobutyric acid-mediated responses in the nucleus tractus solitarius of Sprague-Dawley rats.
Topics: Animals; Baclofen; Baroreflex; Bicuculline; Blood Pressure; Cardiovascular Physiological Phenomena; Dose-Response Relationship, Drug; Food, Formulated; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Heart Rate; Male; Muscimol; Neural Inhibition; Nipecotic Acids; Nitroprusside; Organophosphorus Compounds; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Sodium Chloride, Dietary; Solitary Nucleus | 2004 |
The "Transport Specificity Ratio": a structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysis.
Topics: Binding, Competitive; Catalysis; Escherichia coli; Escherichia coli Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genetic Variation; Models, Molecular; Nipecotic Acids; Organic Anion Transporters; Phenotype; Protein Folding; Quantitative Structure-Activity Relationship; Substrate Specificity | 2004 |
Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cadmium; Citrulline; Cyclic GMP; DEET; Dizocilpine Maleate; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radical Scavengers; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Immunohistochemistry; In Vitro Techniques; Molsidomine; Neural Inhibition; Nipecotic Acids; Nitric Oxide; Potassium; Retina; Silver Staining; Thiourea; Turtles; Vigabatrin | 2005 |
Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Animals, Newborn; Anisoles; Bicuculline; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Synergism; Electric Stimulation; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Membrane Transport Modulators; Membrane Transport Proteins; Models, Neurological; Muscimol; Neocortex; Neural Inhibition; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors | 2005 |
HPLC conditions are critical for the detection of GABA by microdialysis.
Topics: Anesthetics, Local; Animals; Baclofen; Benzylamines; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; GABA Antagonists; gamma-Aminobutyric Acid; Male; Microdialysis; Nipecotic Acids; Phosphinic Acids; Potassium; Rats; Rats, Wistar; Tetrodotoxin; Time Factors | 2005 |
Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.
Topics: Animals; Animals, Newborn; Bicuculline; Cell Count; Citalopram; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamus; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Magnesium; Neurons; Neuropeptides; Nipecotic Acids; Norepinephrine; Orexin Receptors; Orexins; Organophosphorus Compounds; Picrotoxin; Quinolinic Acid; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Selective Serotonin Reuptake Inhibitors; Serotonin | 2005 |
alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Nipecotic Acids; Norepinephrine; Organ Culture Techniques; Rats; Receptors, Adrenergic, alpha-2; Substantia Nigra; Yohimbine | 2006 |
GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control.
Topics: Action Potentials; Animals; Brain Stem; Efferent Pathways; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Nerve Net; Neural Inhibition; Neurons; Nipecotic Acids; Petromyzon; Receptors, GABA-A; Receptors, GABA-B; Receptors, Glycine; Respiratory Center; Respiratory Physiological Phenomena; Sarcosine; Strychnine; Synaptic Transmission | 2006 |
Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study.
Topics: Acetyltransferases; Analysis of Variance; Animals; Baclofen; Dose-Response Relationship, Radiation; Drug Delivery Systems; Electric Stimulation; Electromyography; Evoked Potentials, Motor; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression; H-Reflex; Immunohistochemistry; Male; Muscle Rigidity; Muscle Spasticity; Muscle, Skeletal; Neurologic Examination; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Cord Ischemia; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2 | 2006 |
Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts.
Topics: Alkaline Phosphatase; Animals; Bone Development; Calcium; Carrier Proteins; Cell Survival; Cells, Cultured; Cyclic AMP; Excitatory Amino Acid Agonists; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Immunohistochemistry; Isomerism; Nipecotic Acids; Osmolar Concentration; Osteoblasts; Pregnancy; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Skull; Up-Regulation | 2006 |
Sleep and GABA levels in the oral part of rat pontine reticular formation are decreased by local and systemic administration of morphine.
Topics: Animals; Electroencephalography; Electromyography; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Microdialysis; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nipecotic Acids; Pons; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reticular Formation; Sleep; Wakefulness | 2007 |
Uptake and release of [(3)H]GABA in human dental pulp.
Topics: Adult; Autoreceptors; Baclofen; Dental Pulp; Electric Stimulation; Female; GABA Agents; GABA Agonists; GABA Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Male; Morpholines; Nipecotic Acids; Oximes; Radiopharmaceuticals; Receptors, GABA; Time Factors; Tritium | 2007 |
Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.
Topics: Animals; Anticonvulsants; Carboxylic Acids; Chemistry, Pharmaceutical; Drug Design; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Imidazoles; Inhibitory Concentration 50; Mice; Models, Chemical; Nipecotic Acids; Piperidines; Structure-Activity Relationship; Temperature; Tiagabine | 2007 |
GABA uptake by purified avian Müller glia cells in culture.
Topics: Analysis of Variance; Animals; Biological Transport; Cells, Cultured; Chick Embryo; Chlorides; Coculture Techniques; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Neuroglia; Neurons; Nipecotic Acids; Oximes; Retina; Sodium; Temperature; Tritium | 2007 |
Synaptosomal GABA uptake decreases in paraoxon-treated rat brain.
Topics: Acetylcholinesterase; Animals; beta-Alanine; Brain; Cerebral Cortex; Cholinesterase Inhibitors; Diarrhea; Dose-Response Relationship, Drug; Fasciculation; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Paraoxon; Rats; Rats, Wistar; Salivation; Synaptosomes; Tears; Time Factors; Tremor; Tritium; Urination | 2008 |
Calibration of neurotransmitter release from neural cells for therapeutic implants.
Topics: Action Potentials; Animals; Brain Tissue Transplantation; Cell Culture Techniques; Cell Line; Cell Line, Transformed; Deep Brain Stimulation; Electrodes, Implanted; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Mice; Neurons; Neurotransmitter Agents; Nipecotic Acids; Prostheses and Implants; Silicon Compounds; Synaptic Transmission | 2009 |
Zolpidem modulation of phasic and tonic GABA currents in the rat dorsal motor nucleus of the vagus.
Topics: Action Potentials; Animals; Brain Stem; GABA Agonists; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Miniature Postsynaptic Potentials; Motor Neurons; Muscimol; Nipecotic Acids; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Vagus Nerve; Zolpidem | 2010 |
Glutamatergic excitation and GABA release from a transplantable cell line.
Topics: Calcium; Cell Line; Cell Proliferation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Humans; Magnesium; Nipecotic Acids; Potassium; Temperature | 2010 |
Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanisms.
Topics: Animals; Animals, Newborn; Arousal; Bicuculline; Body Temperature; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heart Rate; Hypoxia; Male; Medulla Oblongata; Models, Animal; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Respiratory Rate; Sleep; Time Factors; Wakefulness | 2012 |
A steered molecular dynamics study of binding and translocation processes in the GABA transporter.
Topics: Anticonvulsants; Binding Sites; Cytoplasm; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Nipecotic Acids; Protein Binding; Protein Conformation; Tiagabine | 2012 |
'À la carte' peptide shuttles: tools to increase their passage across the blood-brain barrier.
Topics: Blood-Brain Barrier; Drug Carriers; gamma-Aminobutyric Acid; Heterocyclic Compounds, 1-Ring; Humans; Nipecotic Acids; Peptides; Permeability; Stereoisomerism | 2014 |
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Isoflurane; Male; Nipecotic Acids; Nociception; Pain Threshold; Pontine Tegmentum; Propofol; Rats, Sprague-Dawley; Reflex, Righting; Sleep Deprivation; Time Factors | 2014 |
Amino acid residues involved in the substrate specificity of TauT/SLC6A6 for taurine and γ-aminobutyric acid.
Topics: Amino Acids; Animals; beta-Alanine; Biological Transport; gamma-Aminobutyric Acid; Membrane Glycoproteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nipecotic Acids; Oocytes; Substrate Specificity; Taurine; Tritium; Xenopus laevis | 2014 |
Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.
Topics: Aminolevulinic Acid; Animals; beta-Alanine; Caco-2 Cells; Cell Line; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kidney; LLC-PK1 Cells; Membrane Glycoproteins; Membrane Transport Proteins; Nicotinic Acids; Nipecotic Acids; Osmolar Concentration; Osmosis; Proline; Rats; RNA, Messenger; Swine; Taurine; Vigabatrin | 2016 |
GABA Uptake Inhibition Reduces In Vivo Extraction Fraction in the Ventral Tegmental Area of Long Evans Rats Measured by Quantitative Microdialysis Under Transient Conditions.
Topics: Amino Acids; Animals; Dopamine; Extracellular Space; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Microdialysis; Neurons; Nipecotic Acids; Nucleus Accumbens; Rats, Long-Evans; Ventral Tegmental Area | 2018 |
Development of New Photoswitchable Azobenzene Based γ-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation.
Topics: Azo Compounds; Biological Transport; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Molecular Docking Simulation; N-Acetylglucosaminyltransferases; Nipecotic Acids; Photochemical Processes; Protein Conformation; Structure-Activity Relationship | 2018 |
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors.
Topics: Alkenes; Dose-Response Relationship, Drug; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Molecular Structure; Nipecotic Acids; Structure-Activity Relationship | 2018 |
Microglial expression of GAT-1 in the cerebral cortex.
Topics: Animals; Cerebral Cortex; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Microglia; Neurons; Nipecotic Acids; Synaptic Transmission; Syntaxin 1 | 2020 |
Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling.
Topics: Amino Acids; Animals; Biological Transport; Brain; Ergolines; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Models, Molecular; Radioligand Assay; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship | 2004 |