nip142 and 2-2-5-7-8-pentamethyl-1-hydroxychroman

nip142 has been researched along with 2-2-5-7-8-pentamethyl-1-hydroxychroman* in 1 studies

Other Studies

1 other study(ies) available for nip142 and 2-2-5-7-8-pentamethyl-1-hydroxychroman

Article	Year
Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells. Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:1 We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (I(Ks)). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC(50) value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 µM and 4.9 µM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current. Topics: Anti-Arrhythmia Agents; Benzopyrans; Chromans; Dose-Response Relationship, Drug; HEK293 Cells; Humans; KCNQ1 Potassium Channel; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated	2011

Article

Year

Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells.

Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:1

We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (I(Ks)). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC(50) value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 µM and 4.9 µM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.

Topics: Anti-Arrhythmia Agents; Benzopyrans; Chromans; Dose-Response Relationship, Drug; HEK293 Cells; Humans; KCNQ1 Potassium Channel; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated

2011