nimesulide has been researched along with n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (31.58) | 18.2507 |
| 2000's | 23 (60.53) | 29.6817 |
| 2010's | 3 (7.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Backlund, A; Bohlin, L; Gottfries, J; Larsson, J | 1 |
| Elagib, KE; Goldfarb, AN; Munson, KM; Peterson, RT; Sweetser, DA; Yeh, JR | 1 |
| Crews, BC; Kalgutkar, AS; Marnett, LJ | 1 |
| Harada, Y; Hatanaka, K; Katori, M; Kawamura, M; Majima, M; Ogino, K; Ogino, M; Ohno, T; Saito, M; Taketani, Y; Yamamoto, K; Yamamoto, S | 1 |
| Bell, RL; Hulkower, KI; Otis, ER; Wernimont, AK | 1 |
| Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H | 1 |
| Hirata, T; Kitamura, M; Takeuchi, K; Ukawa, H | 1 |
| Gilroy, DW; Tomlinson, A; Willoughby, DA | 2 |
| Harada, Y; Hatanaka, K; Kawamura, M; Ogino, K; Ogino, M; Ohno, T; Saito, M; Yang, Q | 1 |
| Holland, E; Knox, AJ; Pang, L | 1 |
| Fujiyoshi, T; Kudo, I; Matsumoto, H; Murakami, M; Naraba, H; Oh-ishi, S; Ueno, A | 1 |
| Gilroy, DW; Greenslade, K; Seed, MP; Tomlinson, A; Willoughby, DA | 1 |
| Wallace, JL | 1 |
| DuBois, RN; Zhang, Z | 1 |
| Dunn, AJ; Swiergiel, AH | 1 |
| Di Battista, JA; Fahmi, H; He, Y; Martel-Pelletier, J; Pelletier, JP; Zhang, M | 1 |
| Aisen, PS; Mukherjee, P; Pasinetti, GM; Rachita, C | 1 |
| An, SJ; Ferreri, NR; McGiff, JC; Wang, D; Wang, WH | 1 |
| Bazan, HE; Ottino, P | 1 |
| Kolaczkowska, E; Plytycz, B; Seljelid, R; Shahzidi, S; van Rooijen, N | 1 |
| Bazan, NG; Chen, C; Magee, JC | 1 |
| Burde, T; Rimon, G | 1 |
| Ito, D; Iwase, M; Kimura, T; Kondo, G; Nagumo, M; Ohashi, M; Watanabe, H | 1 |
| Jänicke, RU; Schulze-Osthoff, K; Totzke, G | 1 |
| Blottière, HM; Bonnet, C; Bouancheau, D; Broquet, A; Buecher, B; Denis, MG; Galmiche, JP; Heymann, MF; Jany, A | 1 |
| Brunette, E; Gendron, TF; Mealing, GA; Morley, P; Nguyen, A; Tauskela, JS | 1 |
| Han, S; Roman, J | 2 |
| Choi, ME; Hiraga, T; Myoui, A; Yoneda, T; Yoshikawa, H | 1 |
| Edwards, RM; Evans, C; Hieble, JP; McCafferty, GP; Wibberley, A | 1 |
| de Leval, X; Julémont, F; Pirotte, B; Renard, JF | 1 |
| Deasy, BM; McKenna, SL; O'Donovan, TR; O'Sullivan, GC; O'Sullivan-Coyne, G | 1 |
| Han, JA; Kim, SR; Lee, ME; Park, JH; Park, JS; Park, SC | 1 |
| Clapper, ML; Foreman, JE; Gonzalez, FJ; McGinnis, KS; Peters, JM; Rigas, B; Sorg, JM; Williams, JL | 1 |
| Cerella, C; Chateauvieux, S; Dicato, M; Diederich, M; Ghelfi, J; Henry, E; Schnekenburger, M; Sobolewski, C | 1 |
| Cerella, C; Dicato, M; Diederich, M; Sobolewski, C | 1 |
| Cha, SA; Gao, S; Kim, SH; Park, BM | 1 |
2 review(s) available for nimesulide and n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
| Article | Year |
|---|---|
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles | 1999 |
The use of nimesulide and its analogues in cancer chemoprevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Neoplasms; Nitrobenzenes; Sulfonamides | 2006 |
36 other study(ies) available for nimesulide and n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
| Article | Year |
|---|---|
Expanding the ChemGPS chemical space with natural products.
Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship | 2005 |
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.
Topics: Animals; Animals, Genetically Modified; beta Catenin; Cell Differentiation; Dinoprostone; Gene Expression Regulation; Humans; K562 Cells; Nitrobenzenes; Oncogene Proteins; Small Molecule Libraries; Sulfonamides; Transcription Factors; Zebrafish; Zebrafish Proteins | 2009 |
Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Hemin; Ibuprofen; Kinetics; Molecular Structure; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostanoic Acids; Protein Binding; Protein Conformation; Sulfonamides; Thiazoles; Trypsin | 1996 |
Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Azo Compounds; Blotting, Western; Carrageenan; Cell Count; Cells, Cultured; Coloring Agents; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Excipients; Inflammation; Isoenzymes; Leukocytes; Male; Nitrobenzenes; Pleura; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thromboxane B2; Trypan Blue | 1996 |
Stimulus dependence of non-steroidal antiinflammatory drug potency in a cellular assay of prostaglandin H synthase-2.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Drug Interactions; Humans; Ibuprofen; Indans; Indomethacin; Interleukin-1; Meclofenamic Acid; Nitrobenzenes; Okadaic Acid; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha | 1997 |
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Acid; Gastric Mucosa; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Rats; Stomach; Stomach Ulcer; Sulfonamides; Taurocholic Acid | 1997 |
Effects of selective cyclooxygenase-2 inhibitors on alkaline secretory and mucosal ulcerogenic responses in rat duodenum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Cyclooxygenase Inhibitors; Dinoprostone; Duodenal Ulcer; Duodenum; Gastric Acid; Histamine; Hydrogen-Ion Concentration; Indomethacin; Intestinal Mucosa; Male; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation.
Topics: Air; Air Sacs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Croton Oil; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Induction; Freund's Adjuvant; Granuloma; Isoenzymes; Membrane Proteins; Mice; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 1998 |
Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Juice; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Pleurisy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sulfonamides; Thromboxane B2 | 1998 |
Impaired cAMP production in human airway smooth muscle cells by bradykinin: role of cyclooxygenase products.
Topics: Adult; Bradykinin; Calcimycin; Cells, Cultured; Cyclic AMP; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dexamethasone; Dinoprostone; Enzyme Induction; Female; Humans; Indomethacin; Isoenzymes; Isoproterenol; Male; Membrane Proteins; Middle Aged; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptor, Bradykinin B2; Receptors, Bradykinin; Sulfonamides; Trachea | 1998 |
Induction of cyclooxygenase-2 causes an enhancement of writhing response in mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Exudates and Transudates; Indans; Indomethacin; Isoenzymes; Male; Mice; Mice, Inbred ICR; Nitrobenzenes; Pain; Pain Measurement; Peritoneum; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 1998 |
Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Piroxicam; Pleural Effusion; Pleurisy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides | 1998 |
The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Bone and Bones; Cartilage, Articular; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Isoenzymes; Male; Mycobacterium tuberculosis; Nitrobenzenes; Piroxicam; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides | 1998 |
Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Northern; Blotting, Western; Carrier Proteins; Colonic Neoplasms; Cyclooxygenase Inhibitors; DNA Fragmentation; Gene Expression; Humans; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Nitrobenzenes; Protein Kinase C; Pyrazoles; RNA, Messenger; Sulfonamides; Sulindac; Tumor Cells, Cultured | 2000 |
The role of cyclooxygenases in endotoxin- and interleukin-1-induced hypophagia.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Drinking; Endotoxins; Feeding and Eating Disorders; Indomethacin; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lipopolysaccharides; Male; Mice; Milk; Nitrobenzenes; Piroxicam; Prostaglandin-Endoperoxide Synthases; Sialoglycoproteins; Sulfonamides | 2000 |
Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Naproxen; Nitrobenzenes; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Synovial Membrane | 2001 |
Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Caspases; Cell Line; Cell Nucleus; Cell Survival; Chondrocytes; Cyclooxygenase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Ibuprofen; Nitrobenzenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Messenger; Staurosporine; Sulfonamides; Time Factors | 2001 |
CaR-mediated COX-2 expression in primary cultured mTAL cells.
Topics: Animals; Calcium; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; Isoenzymes; Loop of Henle; Male; Nitrobenzenes; Peptides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Receptors, Cell Surface; RNA, Messenger; Sulfonamides | 2001 |
Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites.
Topics: Animals; Blotting, Western; Cornea; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Isoenzymes; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Nitrobenzenes; Organ Culture Techniques; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; Sulfonamides; Urokinase-Type Plasminogen Activator | 2001 |
Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Leak Syndrome; Capillary Permeability; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cysteine; Diterpenes; Eicosanoids; Enzyme Induction; Ginkgolides; Histamine Release; Indoles; Indomethacin; Isoenzymes; Lactones; Leukotriene C4; Leukotrienes; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Male; Mast Cells; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Nitrobenzenes; Peritonitis; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Quinolines; Sulfonamides; Thioglycolates; Zymosan | 2002 |
Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity.
Topics: Action Potentials; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dendrites; Dentate Gyrus; Dinoprostone; Excitatory Postsynaptic Potentials; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Nitrobenzenes; Organ Culture Techniques; Perforant Pathway; Presynaptic Terminals; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Sulfonamides; Synapses | 2002 |
On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Binding, Competitive; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ibuprofen; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Sulfonamides | 2002 |
Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils.
Topics: Adult; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Humans; Isoenzymes; Membrane Proteins; Neutrophils; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Superoxides | 2003 |
Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Caspase 3; Caspases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; fas Receptor; Female; HeLa Cells; Humans; Isoenzymes; Membrane Glycoproteins; Membrane Proteins; Mitochondria; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptors, Tumor Necrosis Factor; Sulfonamides; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines.
Topics: Adenocarcinoma; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Division; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flow Cytometry; G1 Phase; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity.
Topics: Animals; Calcium; Canada; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Extracellular Space; Glucose Metabolism Disorders; Glutamates; Hypoxia; Mice; Mice, Inbred C57BL; Neurotoxicity Syndromes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Time Factors | 2004 |
COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cyclooxygenase Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Gene Expression Regulation; Humans; Immunoglobulins; Integrin alpha5; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Phosphorylation; Promoter Regions, Genetic; Sulfonamides; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2005 |
COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals.
Topics: Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Kinase 1; MAP Kinase Kinase Kinase 3; Nitrobenzenes; Oligonucleotides, Antisense; Oncogene Protein p21(ras); Phosphorylation; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Transfection; Tumor Cells, Cultured | 2006 |
Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer.
Topics: Animals; Apoptosis; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Heart Ventricles; Humans; Mice; Neoplasm Transplantation; Nitrobenzenes; Osteoclasts; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Sulfonamides; Transforming Growth Factor beta; Transplantation, Heterologous; Up-Regulation | 2006 |
Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat.
Topics: Acetic Acid; Anesthesia; Animals; Cats; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethacin; Ketoprofen; Male; Nitrobenzenes; Piperazines; Reflex, Abnormal; Sodium Chloride; Sulfonamides; Thiazoles; Urinary Bladder Diseases | 2006 |
Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Esophageal Neoplasms; Humans; Mitochondrial Membranes; Nitrobenzenes; Sulfonamides; Time Factors | 2007 |
Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner.
Topics: Aspirin; Caveolin 1; Celecoxib; Cells, Cultured; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fibroblasts; Flurbiprofen; Humans; Ibuprofen; Kinetics; Models, Biological; NF-kappa B; Nitrobenzenes; Pyrazoles; Reactive Oxygen Species; Skin; Skin Aging; Sulfonamides; Tumor Suppressor Protein p53 | 2008 |
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; Female; Genes, APC; Humans; Indomethacin; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; PPAR delta; PPAR-beta; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Tumor Cells, Cultured | 2009 |
COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; DNA Damage; Dose-Response Relationship, Drug; Hematologic Neoplasms; Humans; K562 Cells; Nitrobenzenes; Pyrazoles; Signal Transduction; Stress, Physiological; Sulfonamides; U937 Cells | 2011 |
Cox-2 inhibitors induce early c-Myc downregulation and lead to expression of differentiation markers in leukemia cells.
Topics: Antigens, Differentiation; Apoptosis; Biomarkers; Celecoxib; Cell Differentiation; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Gene Expression Regulation, Leukemic; Humans; Interphase; Jurkat Cells; K562 Cells; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-myc; Pyrazoles; Sulfonamides; U937 Cells; Up-Regulation | 2011 |
Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release.
Topics: Aldosterone; Angiotensin II; Animals; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Hypertension, Renovascular; Natriuretic Peptide, Brain; Nitrobenzenes; Rats; Sulfonamides | 2015 |