nimesulide and indomethacin

nimesulide has been researched along with indomethacin in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	21 (18.92)	18.2507
2000's	61 (54.95)	29.6817
2010's	27 (24.32)	24.3611
2020's	2 (1.80)	2.80

Authors

Authors	Studies
Barreiro, EJ; Fraga, CA; Lages, AS; Miranda, AL; Silva, KC	1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A	1
Backlund, A; Bohlin, L; Gottfries, J; Larsson, J	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Elagib, KE; Goldfarb, AN; Munson, KM; Peterson, RT; Sweetser, DA; Yeh, JR	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Alcaro, S; Bolasco, A; Cirilli, R; Fioravanti, R; Manna, F; Orallo, F; Ortuso, F; Rossi, F	1
Barbosa Filho, JM; Couto, RD; de Lima, FO; Nonato, FR; Nunes, XP; Ribeiro dos Santos, R; Soares, MB; Villarreal, CF	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Kourounakis, AP; Matralis, AN	1
Arai, J; Hisa, T; Maeda, M; Mukai, T; Ohkubo, Y; Ohshima, T; Saito, Y; Yamamoto, F; Yamamoto, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Abas, F; Abdul Bahari, MN; Ismail, NH; Jalil, J; Jantan, I; Lam, KW; Leong, SW; Lim, SJ; Mohd Aluwi, MFF; Mohd Faudzi, SM; Mohd Fauzi, N; Rullah, K; Yamin, BM	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Bernardino, AMR; Boechat, N; Dos Santos, MS; Faria, JV; Miguita, AGC; Vegi, PF	1
Alcaro, S; Angeli, A; Angius, R; Bianco, G; Capasso, C; Cottiglia, F; Del Prete, S; Deplano, S; Distinto, S; Fois, B; Gaspari, M; Maccioni, E; Meleddu, R; Melis, C; Ortuso, F; Supuran, CT; Taverna, D; Yanez, M	1
Sansano, S; Wiesenberg-Böttcher, I; Zimmerli, W	1
Berti, F; Buschi, A; Robuschi, M; Rossoni, G; Villa, LM	1
Linssen, MJ; Lipponer, L; Seilnacht, W; Wilhelms, OH	1
Casolaro, V; de Paulis, A; Guidi, G; Marino, O; Marone, G; Meliota, S; Patella, V	1
Aldini, G; Carini, M; Macciocchi, A; Maffei Facino, R; Saibene, L	1
Bennett, A; Bishai, PM; Tavares, IA	1
Furukawa, M; Horie, Y; Nakatsugi, S; Terada, N; Yoshimura, T	1
Furukawa, M; Nakatsugi, S; Sugimoto, N	1
Bell, RL; Hulkower, KI; Otis, ER; Wernimont, AK	1
Hirata, T; Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H	1
Hirata, T; Kitamura, M; Takeuchi, K; Ukawa, H	1
Harada, Y; Hatanaka, K; Kawamura, M; Ogino, K; Ogino, M; Ohno, T; Saito, M; Yang, Q	1
Holland, E; Knox, AJ; Pang, L	1
Bjarnason, I; Foster, R; Jacob, M; Mahmud, T; Rafi, S; Roseth, A; Sigthorsson, G; Simpson, R; Somasundaram, S; Tavares, I; Wrigglesworth, J	1
Fujiyoshi, T; Kudo, I; Matsumoto, H; Murakami, M; Naraba, H; Oh-ishi, S; Ueno, A	1
Connolly, C; Docherty, JR; McCormick, PA	1
Aaronson, PI; Bennett, PR; Knock, GA; Poston, L; Sawdy, R	1
Agrewala, JN; Kulkarni, SK; Raghavendra, V	1
Chiang, N; Clària, J; Gaya, J; Pueyo, G; Romano, M; Serhan, CN; Titos, E	1
Wallace, JL	1
Diana, M; Gessa, GL; Melis, M	1
Mitchell, JA; Pepper, JR; Stanford, SJ	1
Cohen, P; Karmeli, F; Rachmilewitz, D	1
Furukawa, M; Horie, Y; Kataoka, H; Koyama, R; Nakatsugi, S	1
Burgaud, JL; Ea-Kim, L; Ghanam, K; Javellaud, J; Lavagna, C; Oudart, N	1
Dunn, AJ; Swiergiel, AH	1
Allen, PC	1
Alican, I; Ercan, F; Oktar, BK; Yeğen, BC	1
Cho, C; Guo, X; Ko, JK; Lam, S; Liu, ES; Wong, BC; Ye, Y	1
Deby, CM; Deby-Dupont, GP; Henrotin, YE; Lamy, MM; Mouithys-Mickalad, AM; Reginster, JY; Zheng, SX	1
FitzGerald, GA; Li, H; Praticò, D; Tillmann, C; Zhang, ZB	1
Azab, AN; Kaplanski, J	1
Bellini, P; Ghidini, A; Locatelli, A; Strobelt, N; Vergani, P	1
Borrelli, F; Tavares, IA; Welsh, NJ	1
Landen, CN; Young, RC; Zhang, P	1
Azab, AN; Kaplanski, J; Shemi, D	1
Bukowski, R; Garfield, RE; McKay, L; Saade, GR; Shi, SQ	1
Kömhoff, M; Nüsing, RM; Peters, M; Reinalter, SC; Seyberth, HW	1
Keelan, JA; Mitchell, MD; Sato, TA	1
Alican, I; Ercan, F; Oktar, BK; Salik, E; San, T	1
Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H	1
Akçay, F; Altinkaynak, K; Süleyman, H	1
Blatteis, CM; Li, S; Llanos-Q, J; Steiner, AA	1
Kolaczkowska, E; Plytycz, B; Seljelid, R; Shahzidi, S; van Rooijen, N	1
Amit, T; Avramovich, Y; Youdim, MB	1
Malhotra, S; Pandhi, P; Shafiq, N	2
Adámeková, E; Ahlers, I; Ahlersová, E; Bojková, B; Chamilová, M; Kalická, K; Kubatka, P	1
Burde, T; Rimon, G	1
Del Soldato, P; Gray, PA; Mitchell, JA; Parikh, A; Scadding, GK; Vojnovic, I; Warner, TD	1
Borrelli, F; Tavares, IA	1
Backhouse, N; Bórquez, J; Delporte, C; Loyola, A; Salinas, P; San-Martín, A	1
Bennett, PR; Fisk, NM; Lye, S; Sawdy, RJ	1
D'Andrea, G; Granella, F	1
Bennett, PR; Sawdy, RJ; Sullivan, MH	1
Hagihara, K; Koshimizu, K; Murakami, A; Ohigashi, H; Takahashi, D	1
Bennett, P; Pan, H; Sawdy, R; Sullivan, M	1
Bennett, PR; Groom, KM; Loudon, JA	1
Itoh, M; Kitamura, T; Matsuura, M; Noda, T; Wakabayashi, K	1
Chu, AC; Fan, ST; Ikeda, K; Kaneda, K; Luk, JM; Man, K; Wang, YQ	1
Cella, M; Farina, M; Franchi, A; Ribeiro, M	1
Gedlicka, C; Knerer, B; Martinek, H; Pelzmann, M; Thurnher, D	1
Lee, EB; Lee, VM; Praticò, D; Shineman, D; Sung, S; Trojanowski, JQ; Uryu, K; Yang, H; Zhao, L	1
Malhotra, S; Nada, R; Pandhi, P; Shafiq, N	1
Centonze, V; Cerbo, R; Grazioli, I; Sternieri, E; Tavolato, B; Trenti, T; Uslenghi, C	1
Bjarnason, I; Bjornsson, E; Maiden, L; Premchand, P; Sherwood, R; Smale, S; Takeuchi, K; Thjodleifsson, B	1
Edwards, RM; Evans, C; Hieble, JP; McCafferty, GP; Wibberley, A	1
Aguirre, MC; Alegría, S; Backhouse, N; Cassels, BK; Delporte, C; Erazo, S; Letelier, ME; Negrete, R; Silva, X	1
Souza, GE; Werner, MF; Zampronio, AR	1
Bishnoi, M; Kulkarni, SK; Kumar, A; Patil, CS	1
Favrais, G; Gressens, P; Lelièvre, V; Schwendimann, L	1
Cadirci, E; Gocer, F; Hacimuftuoglu, A; Halici, Z; Keles, S; Suleyman, H	1
Ettarh, RR; McGarvey, MA; O'Kelly, F	1
Bass, G; Ettarh, RR; McGarvey, MA	1
Nikitakis, NG; Sauk, JJ; Scheper, MA	1
Buyse, M; Farinotti, R; Zrieki, A	1
Clapper, ML; Foreman, JE; Gonzalez, FJ; McGinnis, KS; Peters, JM; Rigas, B; Sorg, JM; Williams, JL	1
Ettarh, R; Meskell, M	1
Cetin, A; Cetin, M; Guvenal, T; Timuroglu, Y; Yanar, O	1
Andrade, CA; de Paiva, VN; Fernandes, MM; Giusti-Paiva, A; Lima, SN; Soncini, R	1
Bao, YJ; Cheng, P; Dai, Q; Jiang, FH; Wang, BJ; Yang, WY; Zhang, YJ; Zhu, LM	1
Díaz-Rodríguez, L; García-Martínez, O; Morales, MA; Rodríguez-Pérez, L; Rubio-Ruiz, B; Ruiz, C	1
Cho, YM; Hasumura, M; Hirose, M; Imai, T; Nishikawa, A; Ogawa, K; Ota, Y; Oyamada, T; Takami, S	1
Abdelrahman, AM; Gomaa, WM; Hafez, HM; Ibrahim, MA; Morsy, MA	1
Järving, R; Kukk, K; Samel, N	1
Alger, BE; Dean, SL; Hoffman, JF; McCarthy, MM; Wang, M; Wright, CL	1
Lopes, D; Nunes, C; Pereira-Leite, C; Pinheiro, M; Reis, S	1
Giusti-Paiva, A; Lima, JBM; Veloso, CC; Vilela, FC	1
Argolo, DS; Arruda, MR; Bispo-da-Silva, A; Costa, MFD; Costa, SL; El-Bachá, RS; Grangeiro, MS; Jesus, EEV; Jesus, LB; Pinheiro, AM; Santos, AB; Santos, RGD	1
Du, S; Gong, J; Jia, L; Liu, S; Wang, M; Zhang, J	1
Yamamoto, Y	1

Reviews

5 review(s) available for nimesulide and indomethacin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Recently reported biological activities of pyrazole compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antineoplastic Agents; Antiviral Agents; Humans; Pyrazoles	2017
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs). The American journal of medicine, 1999, Dec-13, Volume: 107, Issue:6A Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles	1999
Hemicrania horologica ("clock-like hemicrania"). Neurology, 2003, May-27, Volume: 60, Issue:10 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Male; Recurrence; Sulfonamides; Time Factors; Vascular Headaches	2003
Prostaglandin inhibitors in preterm labour. Best practice & research. Clinical obstetrics & gynaecology, 2003, Volume: 17, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cervix Uteri; Cyclooxygenase 2; Ductus Arteriosus; Enzyme Inhibitors; Extraembryonic Membranes; Female; Humans; Indomethacin; Isoenzymes; Kidney; Membrane Proteins; Myometrium; Obstetric Labor, Premature; Pregnancy; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Sulindac; Uterine Contraction	2003

Trials

3 trial(s) available for nimesulide and indomethacin

Article	Year
Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:4 Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Bartter Syndrome; Blood Platelets; Child; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Indomethacin; Isoenzymes; Kidney; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Sulfonamides; Thromboxane B2	2001
A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor. American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:4 Topics: Adult; Amniotic Fluid; Diuresis; Double-Blind Method; Drug Administration Schedule; Ductus Arteriosus; Female; Fetus; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pulse; Sulfonamides; Sulindac; Tocolytic Agents	2003
Efficacy of a fixed combination of indomethacin, prochlorperazine, and caffeine in the treatment of episodic tension-type headache: a double-blind, randomized, nimesulide-controlled, parallel group, multicentre trial. European journal of neurology, 2005, Volume: 12, Issue:10 Topics: Administration, Oral; Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Caffeine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Indomethacin; Male; Middle Aged; Pain Measurement; Prochlorperazine; Retrospective Studies; Sulfonamides; Tension-Type Headache; Time Factors; Treatment Outcome	2005

Other Studies

103 other study(ies) available for nimesulide and indomethacin

Article	Year
Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole. Bioorganic & medicinal chemistry letters, 1998, Jan-20, Volume: 8, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Evaluation; Edema; Female; Indans; Male; Pleurisy; Rats; Safrole	1998
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism	2005
Expanding the ChemGPS chemical space with natural products. Journal of natural products, 2005, Volume: 68, Issue:7 Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship	2005
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nature chemical biology, 2009, Volume: 5, Issue:4 Topics: Animals; Animals, Genetically Modified; beta Catenin; Cell Differentiation; Dinoprostone; Gene Expression Regulation; Humans; K562 Cells; Nitrobenzenes; Oncogene Proteins; Small Molecule Libraries; Sulfonamides; Transcription Factors; Zebrafish; Zebrafish Proteins	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:12 Topics: Animals; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Insecta; Models, Molecular; Molecular Structure; Pyrazoles; Stereoisomerism; Structure-Activity Relationship	2010
Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin. Journal of natural products, 2011, Apr-25, Volume: 74, Issue:4 Topics: Analgesics; Animals; Brazil; Dinoprostone; Edema; Freund's Adjuvant; Mice; Models, Animal; Molecular Structure; Neutrophils; Pain; Pain Measurement; Tumor Necrosis Factor-alpha; Umbelliferones	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity. Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; Carrageenan; Cholesterol, Dietary; Cyclooxygenase Inhibitors; Diet, High-Fat; Drug Design; Edema; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hypolipidemic Agents; In Vitro Techniques; Indicators and Reagents; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes; Phenothiazines; Picrates; Rats	2014
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties. Bioorganic & medicinal chemistry, 2015, Nov-01, Volume: 23, Issue:21 Topics: Brain; Caco-2 Cells; Catalytic Domain; Contrast Media; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Isomerism; Molecular Conformation; Molecular Dynamics Simulation; Protein Binding; Sulfonamides	2015
Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines. Bioorganic & medicinal chemistry letters, 2016, 05-15, Volume: 26, Issue:10 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Curcumin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Humans; I-kappa B Kinase; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 9; Molecular Docking Simulation	2016
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides. ACS medicinal chemistry letters, 2018, Oct-11, Volume: 9, Issue:10 Topics:	2018
Influence of the anti-inflammatory compound flosulide on granulocyte function. Biochemical pharmacology, 1991, Oct-24, Volume: 42, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemotaxis; Ibuprofen; Indans; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piroxicam; Sulfonamides; Superoxides	1991
Antianaphylactic and antihistaminic activity of the non-steroidal anti-inflammatory compound nimesulide in guinea-pig. Arzneimittel-Forschung, 1990, Volume: 40, Issue:9 Topics: Airway Resistance; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Blood Pressure; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Indomethacin; Lung; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Rabbits; Sulfonamides; Thromboxane A2; Trachea	1990
Nimesulide, indomethacin, BW 755 C, phenidon, mepacrin and nedocromil inhibit the activation of human and rat leucocytes. International journal of tissue reactions, 1990, Volume: 12, Issue:2 Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; In Vitro Techniques; Indomethacin; Leukocytes; Lipoxygenase Inhibitors; Luminescent Measurements; Nedocromil; Phospholipases A; Pyrazoles; Quinacrine; Quinolones; Rats; Sulfonamides	1990
Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3 Topics: Adolescent; Adult; Alprostadil; Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Basophils; Bryostatins; Calcimycin; Colforsin; Complement C5a; Histamine Release; Humans; Immunoglobulin E; Indomethacin; Lactones; Leukotriene C4; Lung; Macrolides; Mast Cells; Middle Aged; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandin D2; Skin; Sulfonamides; Tetradecanoylphorbol Acetate	1993
Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model. International journal of tissue reactions, 1993, Volume: 15, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Diclofenac; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Indomethacin; Liposomes; Membranes, Artificial; Models, Biological; Phosphatidylcholines; Sulfonamides	1993
Activity of nimesulide on constitutive and inducible cyclooxygenases. Arzneimittel-Forschung, 1995, Volume: 45, Issue:10 Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase Inhibitors; Enzyme Induction; Gastric Mucosa; Humans; In Vitro Techniques; Indomethacin; Leukocytes; Male; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Radioimmunoassay; Sheep; Sulfonamides	1995
Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats. Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 55, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Excipients; Exudates and Transudates; Gastric Mucosa; Gastritis; Ibuprofen; Indomethacin; Isoenzymes; Male; Membrane Proteins; Pleurisy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stress, Physiological; Sulfonamides	1996
Effects of non-steroidal anti-inflammatory drugs on prostaglandin E2 production by cyclooxygenase-2 from endogenous and exogenous arachidonic acid in rat peritoneal macrophages stimulated with lipopolysaccharide. Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 55, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Ibuprofen; Indomethacin; Isoenzymes; Lipopolysaccharides; Macrophages, Peritoneal; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides	1996
Stimulus dependence of non-steroidal antiinflammatory drug potency in a cellular assay of prostaglandin H synthase-2. European journal of pharmacology, 1997, Jul-16, Volume: 331, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Drug Interactions; Humans; Ibuprofen; Indans; Indomethacin; Interleukin-1; Meclofenamic Acid; Nitrobenzenes; Okadaic Acid; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Tumor Necrosis Factor-alpha	1997
Cyclo-oxygenase isozymes in mucosal ulcergenic and functional responses following barrier disruption in rat stomachs. British journal of pharmacology, 1997, Volume: 122, Issue:3 Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Acid; Gastric Mucosa; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Rats; Stomach; Stomach Ulcer; Sulfonamides; Taurocholic Acid	1997
Effects of selective cyclooxygenase-2 inhibitors on alkaline secretory and mucosal ulcerogenic responses in rat duodenum. Life sciences, 1997, Volume: 61, Issue:16 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Cyclooxygenase Inhibitors; Dinoprostone; Duodenal Ulcer; Duodenum; Gastric Acid; Histamine; Hydrogen-Ion Concentration; Indomethacin; Intestinal Mucosa; Male; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Sulfonamides	1997
Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat. Prostaglandins & other lipid mediators, 1998, Volume: 55, Issue:5-6 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Juice; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Pleurisy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sulfonamides; Thromboxane B2	1998
Impaired cAMP production in human airway smooth muscle cells by bradykinin: role of cyclooxygenase products. The American journal of physiology, 1998, Volume: 275, Issue:2 Topics: Adult; Bradykinin; Calcimycin; Cells, Cultured; Cyclic AMP; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dactinomycin; Dexamethasone; Dinoprostone; Enzyme Induction; Female; Humans; Indomethacin; Isoenzymes; Isoproterenol; Male; Membrane Proteins; Middle Aged; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Receptor, Bradykinin B2; Receptors, Bradykinin; Sulfonamides; Trachea	1998
Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. Scandinavian journal of gastroenterology, 1998, Volume: 33, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane Permeability; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Feces; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Male; Microscopy, Electron; Mitochondria; Oxygen Consumption; Prostaglandins; Rats; Rats, Sprague-Dawley; Reference Values; Statistics, Nonparametric; Sulfonamides	1998
Induction of cyclooxygenase-2 causes an enhancement of writhing response in mice. European journal of pharmacology, 1998, Jul-03, Volume: 352, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Exudates and Transudates; Indans; Indomethacin; Isoenzymes; Male; Mice; Mice, Inbred ICR; Nitrobenzenes; Pain; Pain Measurement; Peritoneum; Prostaglandin-Endoperoxide Synthases; Sulfonamides	1998
Effects of the selective cyclooxygenase-2 inhibitor nimesulide on vascular contractions in endothelium-denuded rat aorta. European journal of pharmacology, 1998, Jul-03, Volume: 352, Issue:1 Topics: Animals; Aorta; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelin-1; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Muscle Contraction; Nifedipine; Phenylephrine; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides	1998
Effect of nimesulide and indomethacin on contractility and the Ca2+ channel current in myometrial smooth muscle from pregnant women. British journal of pharmacology, 1998, Volume: 125, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Calcium Channels; Cyclooxygenase Inhibitors; Female; Humans; In Vitro Techniques; Indomethacin; Isometric Contraction; Myometrium; Pregnancy; Sulfonamides; Uterine Contraction	1998
Role of centrally administered melatonin and inhibitors of COX and NOS in LPS-induced hyperthermia and adipsia. Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 60, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyclooxygenase Inhibitors; Dinoprostone; Fever; Indomethacin; Lipopolysaccharides; Male; Melatonin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sulfonamides; Thirst; Time Factors	1999
Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). The American journal of physiology, 1999, Volume: 277, Issue:5 Topics: Animals; Aspirin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Isoenzymes; Lipoxins; Liver; Male; Membrane Proteins; Phenobarbital; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Thromboxane B2	1999
Cyclo-oxygenase-inhibitors increase morphine effects on mesolimbic dopamine neurons. European journal of pharmacology, 2000, Jan-03, Volume: 387, Issue:1 Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Indomethacin; Injections, Intravenous; Limbic System; Male; Morphine; Narcotics; Neurons; Rats; Rats, Sprague-Dawley; Sulfonamides	2000
Cyclooxygenase-2 regulates granulocyte-macrophage colony-stimulating factor, but not interleukin-8, production by human vascular cells: role of cAMP. Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arteriosclerosis; Aspirin; Bucladesine; Cells, Cultured; Cyclic AMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indans; Indomethacin; Interleukin-1; Interleukin-8; Isoenzymes; Mammary Arteries; Meloxicam; Membrane Proteins; Muscle, Smooth, Vascular; Neutrophils; Prostaglandin-Endoperoxide Synthases; Saphenous Vein; Sulfonamides; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha	2000
Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase Inhibitors; Disease Models, Animal; Eicosanoids; Indomethacin; Inflammation; Interleukin-1; Male; Nitric Oxide Synthase; Peroxidase; Pyrazoles; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Tumor Necrosis Factor-alpha	2000
Interaction between NSAIDs and steroid in rat stomach: safety of nimesulide as a preferential COX-2 inhibitor in the stomach. Digestive diseases and sciences, 2000, Volume: 45, Issue:7 Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA; Drug Interactions; Drug Synergism; Gastric Mucosa; Gastrointestinal Motility; Indomethacin; Isoenzymes; Male; Membrane Proteins; Peroxidase; Prednisolone; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach; Stomach Ulcer; Sulfonamides	2000
Involvement of cyclooxygenase 2 in the protective effect of 17beta-estradiol on hypercholesterolemic rabbit aorta. Biochemical and biophysical research communications, 2000, Aug-28, Volume: 275, Issue:2 Topics: Acetylcholine; Adenine; Animals; Aorta; Aspirin; Cholesterol; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Estradiol; Hypercholesterolemia; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Triglycerides	2000
The role of cyclooxygenases in endotoxin- and interleukin-1-induced hypophagia. Brain, behavior, and immunity, 2000, Volume: 14, Issue:3 Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Drinking; Endotoxins; Feeding and Eating Disorders; Indomethacin; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lipopolysaccharides; Male; Mice; Milk; Nitrobenzenes; Piroxicam; Prostaglandin-Endoperoxide Synthases; Sialoglycoproteins; Sulfonamides	2000
Effects of treatments with cyclooxygenase inhibitors on chickens infected with Eimeria acervulina. Poultry science, 2000, Volume: 79, Issue:9 Topics: Animals; Chickens; Coccidiosis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Eimeria; Feces; Indomethacin; Isoenzymes; Male; Nitrates; Nitrites; Parasite Egg Count; Poultry Diseases; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Weight Gain	2000
The effect of alpha-melanocyte stimulating hormone on colonic inflammation in the rat. Peptides, 2000, Volume: 21, Issue:8 Topics: alpha-MSH; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Colitis; Cyclooxygenase 1; Female; Free Radical Scavengers; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Trinitrobenzenesulfonic Acid	2000
Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats. European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2 Topics: Animals; Blotting, Western; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Enzymologic; Indomethacin; Inflammation; Inflammatory Bowel Diseases; Isoenzymes; Leukotriene B4; Male; Membrane Proteins; Peroxidase; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tobacco Smoke Pollution; Trinitrobenzenesulfonic Acid	2001
In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR). Free radical research, 2000, Volume: 33, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Chlorine; Diclofenac; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; In Vitro Techniques; Indicators and Reagents; Indomethacin; Iron; Kinetics; Lipid Peroxidation; Luminescent Measurements; Neutrophil Activation; Neutrophils; Nitrates; Reactive Oxygen Species; Sodium Hypochlorite; Spectrophotometry, Ultraviolet; Sulfonamides; Tetradecanoylphorbol Acetate	2000
Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-13, Volume: 98, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epoprostenol; Female; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Receptors, LDL; Sulfonamides; Thromboxane B2	2001
A reduction of tumor necrosis factor-alpha in paw exudate of lipopolysaccharide treated rats by nimesulide. Life sciences, 2001, Feb-23, Volume: 68, Issue:14 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Edema; Exudates and Transudates; Indomethacin; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; Sulfonamides; Tumor Necrosis Factor-alpha	2001
Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin? BJOG : an international journal of obstetrics and gynaecology, 2001, Volume: 108, Issue:3 Topics: Administration, Oral; Adult; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Obstetric Labor, Premature; Oligohydramnios; Pilot Projects; Pregnancy; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tocolytic Agents; Treatment Outcome	2001
Inhibition of gastric acid secretion by nimesulide: a possible factor in its gastric tolerability. Clinical and experimental rheumatology, 2001, Volume: 19, Issue:1 Suppl 22 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred C57BL; Muscarine; Perfusion; Sulfonamides	2001
Differing mechanisms of inhibition of calcium increases in human uterine myocytes by indomethacin and nimesulide. American journal of obstetrics and gynecology, 2001, Volume: 184, Issue:6 Topics: Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprost; Female; Humans; Indomethacin; Intracellular Membranes; Muscle, Smooth; Reference Values; Sulfonamides; Tocolytic Agents; Uterus	2001
Time-dependent effect of LPS on PGE2 and TNF-alpha production by rat glial brain culture: influence of COX and cytokine inhibitors. Journal of endotoxin research, 2000, Volume: 6, Issue:5 Topics: Animals; Brain; Cells, Cultured; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Indomethacin; Kinetics; Lipopolysaccharides; Neuroglia; Pentoxifylline; Rats; Sulfonamides; Tumor Necrosis Factor-alpha	2000
The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats. American journal of obstetrics and gynecology, 2001, Volume: 185, Issue:4 Topics: Administration, Topical; Animals; Cervical Ripening; Cervix Uteri; Cyclooxygenase Inhibitors; Delivery, Obstetric; Female; Fetal Death; Guanidines; Indomethacin; Models, Animal; NG-Nitroarginine Methyl Ester; Pregnancy; Pregnancy Outcome; Pregnancy, Animal; Probability; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Statistics, Nonparametric; Sulfonamides; Treatment Outcome	2001
Regulation of prostaglandin production in an immortalized human myometrial cell line by cytokines and non-steroidal anti-inflammatory drugs. European journal of obstetrics, gynecology, and reproductive biology, 2002, Jan-10, Volume: 100, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Transformed; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Enzyme Inhibitors; Etodolac; Female; Furans; Humans; Indomethacin; Interleukin-1; Prostaglandins; Sulfonamides; Tumor Necrosis Factor-alpha	2002
The effect of alpha-melanocyte stimulating hormone on endotoxin-induced intestinal injury. Peptides, 2001, Volume: 22, Issue:12 Topics: alpha-MSH; Animals; Cyclooxygenase Inhibitors; Female; Indomethacin; Intestines; Lipopolysaccharides; Male; Microscopy, Electron, Scanning; Rats; Rats, Sprague-Dawley; Sulfonamides	2001
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. Inflammation, 2001, Volume: 25, Issue:5 Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Indomethacin; Inflammation; Inflammatory Bowel Diseases; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Trinitrobenzenesulfonic Acid	2001
The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats. Pharmacological research, 2002, Volume: 45, Issue:2 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Indomethacin; Male; Ranitidine; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides	2002
Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs. Neuroimmunomodulation, 2001, Volume: 9, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Fever; Guinea Pigs; Indomethacin; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Isoenzymes; Lipopolysaccharides; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides	2001
Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. Inflammation, 2002, Volume: 26, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Leak Syndrome; Capillary Permeability; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cysteine; Diterpenes; Eicosanoids; Enzyme Induction; Ginkgolides; Histamine Release; Indoles; Indomethacin; Isoenzymes; Lactones; Leukotriene C4; Leukotrienes; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Male; Mast Cells; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Nitrobenzenes; Peritonitis; Phospholipid Ethers; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Quinolines; Sulfonamides; Thioglycolates; Zymosan	2002
Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. The Journal of biological chemistry, 2002, Aug-30, Volume: 277, Issue:35 Topics: Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Enzyme Activation; Humans; Ibuprofen; Indomethacin; Kinetics; Mitogen-Activated Protein Kinases; Neuroblastoma; PC12 Cells; Pheochromocytoma; Rats; Sulfonamides; Thalidomide; Tumor Cells, Cultured	2002
Effect of cyclooxygenase inhibitors in postoperative ileus: an experimental study. Methods and findings in experimental and clinical pharmacology, 2002, Volume: 24, Issue:5 Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethacin; Intestinal Obstruction; Male; Postoperative Complications; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides	2002
Nimesulide and melatonin in mammary carcinogenesis prevention in female Sprague-Dawley rats. Neoplasma, 2002, Volume: 49, Issue:4 Topics: Animals; Anticarcinogenic Agents; Carbohydrate Metabolism; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female; Indomethacin; Isoenzymes; Lipid Metabolism; Mammary Neoplasms, Experimental; Melatonin; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfonamides	2002
On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1. European journal of pharmacology, 2002, Oct-25, Volume: 453, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Binding, Competitive; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ibuprofen; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Sulfonamides	2002
Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors. British journal of pharmacology, 2002, Volume: 137, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Benzene Derivatives; Calcimycin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Furans; Humans; Indomethacin; Ionophores; Isoenzymes; Leukotrienes; Lipopolysaccharides; Lipoxygenase; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane B2	2002
Effect of nimesulide on gastric acid secretion in the mouse stomach in vitro. Life sciences, 2003, Jan-10, Volume: 72, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Combinations; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred C57BL; Stomach; Sulfonamides	2003
Pharmaco-toxicological study of diterpenoids. Bioorganic & medicinal chemistry, 2003, Apr-03, Volume: 11, Issue:7 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apiaceae; Arachidonic Acid; Chile; Diterpenes; Dose-Response Relationship, Drug; Edema; Female; Indicators and Reagents; Indomethacin; Lipoxygenase Inhibitors; Male; Mice; Molecular Conformation; Naproxen; Pain Measurement; Plants, Medicinal; Structure-Activity Relationship; Sulfonamides; Tetradecanoylphorbol Acetate	2003
The effects of non-steroidal anti-inflammatory compounds on human myometrial contractility. European journal of obstetrics, gynecology, and reproductive biology, 2003, Jul-01, Volume: 109, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Myometrium; Organic Chemicals; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Sulfonamides; Thiazines; Thiazoles; Uterine Contraction	2003
Combinatorial effects of nonsteroidal anti-inflammatory drugs and food constituents on production of prostaglandin E2 and tumor necrosis factor-alpha in RAW264.7 murine macrophages. Bioscience, biotechnology, and biochemistry, 2003, Volume: 67, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Catechin; Cell Line; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; Food Analysis; Food-Drug Interactions; Genistein; Indicators and Reagents; Indomethacin; Interferon-gamma; Isothiocyanates; Lipopolysaccharides; Macrophages; Mice; Protein Biosynthesis; Spectrophotometry, Infrared; Sulfonamides; Tumor Necrosis Factor-alpha	2003
Effect of selective vs. non-selective cyclo-oxygenase inhibitors on fetal membrane prostaglandin synthesis. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2003, Volume: 23, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Extraembryonic Membranes; Female; Furans; Humans; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Meloxicam; Membrane Proteins; Pregnancy; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thiazines; Thiazoles	2003
Comparison of nonselective cyclo-oxygenase (COX) inhibitor and selective COX-2 inhibitors on preimplantation loss, postimplantation loss and duration of gestation: an experimental study. Contraception, 2004, Volume: 69, Issue:1 Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Embryonic Development; Female; Gestational Age; Indomethacin; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Sulfonamides	2004
Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. International journal of cancer, 2004, Apr-20, Volume: 109, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Genes, APC; Indomethacin; Intestinal Neoplasms; Intestinal Polyps; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Mice, Knockout; Neoplasms, Experimental; Prostaglandin-Endoperoxide Synthases; Sulfonamides	2004
Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells. Biochemical and biophysical research communications, 2004, Apr-30, Volume: 317, Issue:2 Topics: Animals; Carrier Proteins; Cell Hypoxia; Cell Line; Cyclooxygenase 2; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Hepatocytes; Homeostasis; Hypoxia-Inducible Factor 1, alpha Subunit; Indomethacin; Isoenzymes; Molecular Chaperones; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides; Transcription Factors; Vascular Endothelial Growth Factor A	2004
Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus. Neuroimmunomodulation, 2004, Volume: 11, Issue:3 Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Down-Regulation; Embryo Loss; Estrogens; Female; Guanidines; Indomethacin; Inflammation; Isoenzymes; Lipopolysaccharides; Meloxicam; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Sulfonamides; Thiazines; Thiazoles; Uterus	2004
Nimesulide and indomethacin induce apoptosis in head and neck cancer cells. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2004, Volume: 33, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Head and Neck Neoplasms; Humans; Indomethacin; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Tumor Cells, Cultured	2004
Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. The American journal of pathology, 2004, Volume: 165, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebellar Cortex; Cyclooxygenase 1; Cyclooxygenase 2; Female; Glial Fibrillary Acidic Protein; Hippocampus; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Transgenic; Models, Animal; NF-kappa B; NIH 3T3 Cells; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides	2004
Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors. Indian journal of experimental biology, 2005, Volume: 43, Issue:7 Topics: Animals; Celecoxib; Colitis; Cyclooxygenase Inhibitors; Gastric Mucosa; Gastrointestinal Tract; Indomethacin; Male; Pyrazoles; Rats; Rats, Wistar; Reperfusion Injury; Sulfonamides	2005
Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:2 Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colitis, Ulcerative; Crohn Disease; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Indomethacin; Inflammatory Bowel Diseases; Male; Middle Aged; Nabumetone; Naproxen; Prevalence; Recurrence; Sulfonamides	2006
Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat. British journal of pharmacology, 2006, Volume: 148, Issue:2 Topics: Acetic Acid; Anesthesia; Animals; Cats; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethacin; Ketoprofen; Male; Nitrobenzenes; Piperazines; Reflex, Abnormal; Sodium Chloride; Sulfonamides; Thiazoles; Urinary Bladder Diseases	2006
Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorganic & medicinal chemistry, 2006, Aug-15, Volume: 14, Issue:16 Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Betulinic Acid; Dose-Response Relationship, Drug; Indomethacin; Male; Mice; Myrtaceae; Otitis Externa; Pentacyclic Triterpenes; Plant Leaves; Polycyclic Compounds; Sulfonamides; Tetradecanoylphorbol Acetate; Triterpenes	2006
Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. European journal of pharmacology, 2006, Aug-14, Volume: 543, Issue:1-3 Topics: Analgesics, Non-Narcotic; Animals; Arachidonic Acid; Body Temperature; Chemokine CCL3; Chemokine CCL4; Corticotropin-Releasing Hormone; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Endothelin-1; Fever; Indomethacin; Injections, Intraperitoneal; Injections, Intraventricular; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophage Inflammatory Proteins; Male; Rats; Rats, Wistar; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha	2006
Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice. Pharmacology, 2007, Volume: 79, Issue:1 Topics: Administration, Oral; Animals; Antinematodal Agents; Brain; Catalase; Cyclooxygenase 2 Inhibitors; Drug Synergism; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Glutathione; Indomethacin; Injections, Intraperitoneal; Kainic Acid; Lactones; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred Strains; Nitric Oxide; Peroxidase; Sulfonamides; Sulfones; Triterpenes	2007
Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice. Neurobiology of disease, 2007, Volume: 25, Issue:3 Topics: Animals; Animals, Newborn; Brain; Cerebral Palsy; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation, Enzymologic; Ibotenic Acid; Indomethacin; Interleukin-1beta; Mice; Neurotoxins; Pregnancy; Risk Factors; Sulfonamides	2007
Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats. Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:3 Topics: Adrenalectomy; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Doxazosin; Epinephrine; Indomethacin; Male; Metyrapone; Prednisolone; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Stomach Ulcer; Sulfonamides; Yohimbine	2007
Nimesulide inhibits crypt epithelial cell proliferation at 6 hours in the small intestine in CD-1 mice. Digestive diseases and sciences, 2007, Volume: 52, Issue:9 Topics: Animals; Calcium Channel Blockers; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Epithelial Cells; Follow-Up Studies; Indomethacin; Intestine, Small; Male; Mice; Photomicrography; Sulfonamides	2007
Nimesulide alters cell recruitment into mitosis in murine intestinal crypts without influencing the cell production rate. Digestive diseases and sciences, 2007, Volume: 52, Issue:6 Topics: Animals; Cell Proliferation; Cyclooxygenase Inhibitors; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Mice; Mitosis; Sulfonamides	2007
Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer. International journal of oral and maxillofacial surgery, 2007, Volume: 36, Issue:7 Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Celecoxib; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2 Inhibitors; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Inhibitors; Humans; Immunohistochemistry; Indomethacin; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Pyrazoles; Signal Transduction; STAT3 Transcription Factor; Sulfonamides; Sulindac; Survivin; Tongue Neoplasms; Tumor Cells, Cultured	2007
Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line. Pharmaceutical research, 2008, Volume: 25, Issue:9 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Caco-2 Cells; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Naproxen; Neoplasm Proteins; Pyrazoles; Reproducibility of Results; RNA, Messenger; Sulfonamides; Time Factors	2008
Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. Molecular carcinogenesis, 2009, Volume: 48, Issue:10 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Blotting, Western; Celecoxib; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; Female; Genes, APC; Humans; Indomethacin; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; PPAR delta; PPAR-beta; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Tumor Cells, Cultured	2009
Immunohistochemical localisation of renal cyclooxygenase-1 expression in non-steroidal anti-inflammatory drug-treated mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2011, Volume: 63, Issue:1-2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Dose-Response Relationship, Drug; Immunohistochemistry; Indomethacin; Kidney; Kidney Cortex; Kidney Medulla; Male; Mice; Mice, Inbred Strains; Sulfonamides	2011
Effects of selective and non-selective cyclooxygenase (COX) inhibitors on postoperative adhesion formation in a rat uterine horn model. Clinical and experimental obstetrics & gynecology, 2010, Volume: 37, Issue:1 Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Female; Indomethacin; Postoperative Complications; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Tissue Adhesions; Uterus	2010
Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice. Behavioural brain research, 2010, Dec-20, Volume: 215, Issue:1 Topics: Analysis of Variance; Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Depression; Dexamethasone; Exploratory Behavior; Feeding Behavior; Glucocorticoids; Hindlimb Suspension; Illness Behavior; Indomethacin; Lipopolysaccharides; Mice; Motor Activity; Prostaglandins; Stress, Physiological; Sulfonamides; Tail	2010
mTOR signaling is involved in indomethacin and nimesulide suppression of colorectal cancer cell growth via a COX-2 independent pathway. Annals of surgical oncology, 2011, Volume: 18, Issue:2 Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Indomethacin; Male; Mice; Mice, Inbred BALB C; Mice, Nude; RNA, Small Interfering; Signal Transduction; Sulfonamides; Tumor Cells, Cultured	2011
Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line. Biological research for nursing, 2012, Volume: 14, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Diclofenac; Flow Cytometry; Humans; Indomethacin; Osteocalcin; Osteosarcoma; Sulfonamides	2012
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine. Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 127, Issue:2 Topics: Adenocarcinoma, Follicular; Animals; Antithyroid Agents; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Immunohistochemistry; Indomethacin; Intramolecular Oxidoreductases; Male; Nitrosamines; Organ Size; Precancerous Conditions; Prostaglandin-E Synthases; Rats; Rats, Inbred F344; Sulfadimethoxine; Sulfonamides; Thyroid Gland; Thyroid Hormones; Thyroid Neoplasms; Time Factors	2012
Effect of selective and non-selective cyclooxygenase inhibitors on doxorubicin-induced cardiotoxicity and nephrotoxicity in rats. Toxicology mechanisms and methods, 2012, Volume: 22, Issue:6 Topics: Animals; Antineoplastic Agents; Cyclooxygenase 2 Inhibitors; Doxorubicin; Glutathione; Heart; Immunohistochemistry; Indomethacin; Kidney; Male; Malondialdehyde; Rats; Rats, Wistar; Sulfonamides	2012
Purification and characterization of the recombinant human prostaglandin H synthase-2 expressed in Pichia pastoris. Protein expression and purification, 2012, Volume: 83, Issue:2 Topics: Arachidonic Acid; Cyclooxygenase 2; Detergents; Histidine; Humans; Indomethacin; Oligopeptides; Pichia; Recombinant Proteins; Sulfonamides	2012
Prostaglandin E2 stimulates estradiol synthesis in the cerebellum postnatally with associated effects on Purkinje neuron dendritic arbor and electrophysiological properties. Endocrinology, 2012, Volume: 153, Issue:11 Topics: Action Potentials; Animals; Aromatase; Cells, Cultured; Cerebellum; Cyclooxygenase Inhibitors; Dendrites; Dendritic Spines; Dinoprostone; Estradiol; Female; Indomethacin; Male; Microfilament Proteins; Nerve Tissue Proteins; Purkinje Cells; Rats; Rats, Sprague-Dawley; Sulfonamides	2012
In vitro assessment of NSAIDs-membrane interactions: significance for pharmacological actions. Pharmaceutical research, 2013, Volume: 30, Issue:8 Topics: 1,2-Dipalmitoylphosphatidylcholine; Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane; Indomethacin; Liposomes; Spectrometry, Fluorescence; Sulfonamides; Thermodynamics	2013
Prostaglandins mediate zymosan-induced sickness behavior in mice. The journal of physiological sciences : JPS, 2017, Volume: 67, Issue:6 Topics: Animals; Behavior, Animal; Dexamethasone; Dose-Response Relationship, Drug; Glucocorticoids; Illness Behavior; Indomethacin; Male; Mice; Prostaglandin Antagonists; Prostaglandins; Sulfonamides; Zymosan	2017
IDO, COX and iNOS have an important role in the proliferation of Neospora caninum in neuron/glia co-cultures. Veterinary parasitology, 2019, Volume: 266 Topics: Animals; Cells, Cultured; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Host-Parasite Interactions; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indomethacin; Interleukin-10; Neospora; Neuroglia; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats; Sulfonamides; Tryptophan; Tumor Necrosis Factor-alpha	2019
Exploring the physical stability of three nimesulide-indomethacin co-amorphous systems from the perspective of molecular aggregates. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Apr-30, Volume: 147 Topics: Drug Liberation; Drug Stability; Glass; Hydrogen Bonding; Indomethacin; Molecular Structure; Powder Diffraction; Solubility; Sulfonamides; Technology, Pharmaceutical; Transition Temperature; X-Ray Diffraction	2020
[Development of Novel COX-2 Imaging Agents for the Diagnosis of Brain Lesions]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2023, Volume: 143, Issue:12 Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Indomethacin	2023