nilutamide and flutamide

nilutamide has been researched along with flutamide in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (15.58)	18.7374
1990's	31 (40.26)	18.2507
2000's	26 (33.77)	29.6817
2010's	7 (9.09)	24.3611
2020's	1 (1.30)	2.80

Authors

Authors	Studies
Cogan, PS; Koch, TH	2
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Bender, A; Czobor, P; Jelinek, B; Málnási-Csizmadia, A; Peragovics, Á; Simon, Z; Tombor, L; Végner, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Akimoto, S; Higa, T; Isaka, S; Masai, M; Shimazaki, J	1
Denis, L	1
Mora, G; Muldoon, TG; Steinsapir, J	1
Crawford, ED; Nabors, WL	1
Pavone-Macaluso, M	1
Brand, T; Slob, AK	1
Schröder, FH	2
Cacciatore, M; Cavallo, N; Daricello, G; Pavone, C; Pavone-Macaluso, M; Romano, C; Serretta, V	1
Cacciatore, M; Daricello, G; Pavone, C; Pavone-Macaluso, M; Serretta, V	1
Dhar, JD; Setty, BS	1
Namer, M	1
Furr, BJ	2
Daricello, G; Pavone, C; Pavone-Macaluso, M; Romano, C; Serretta, V	1
Bélanger, A; Dupont, A; Labrie, F; Lacourcière, Y; Monfette, G; Monfette, JE	1
Ayub, M; Levell, MJ	1
Dupront, A; Meyer, BH; Pottier, J; Tremblay, D	1
Bruchovsky, N; Fletcher, T; Foekens, JA; Goldenberg, SL; Lawson, D; Rennie, PS	1
Dupont, A; Harnois, C; Labrie, F; Malenfant, M	1
Burton, S; Trachtenberg, J	1
Bertagna, C; Coussedière, D; Husson, JM; Moguilewsky, M; Pendyala, L; Pottier, J; Raynaud, JP; Salmon, J; Tournemine, C; Tremblay, D	1
Pandha, H; Waxman, J	1
Bentel, JM; Birrell, SN; Hickey, TE; Horsfall, DJ; Ricciardelli, C; Tilley, WD; Weger, MA	1
Govindan, MV; Koutsilieris, M; Pagé, N; Warriar, N	2
McLeod, DG	1
Matzkin, H; Soloway, MS	1
Benassayag, E	1
Dole, EJ; Holdsworth, MT	1
Kaisary, AV	1
Labrie, F; Simard, J; Singh, SM	1
Eastham, JA; Sartor, O	1
Lansiaux, P	1
Boccon-Gibod, L	1
Battmann, T; Bouchoux, F; Branche, C; Cerede, E; Gaillard-Kelly, M; Goubet, F; Philibert, D; Teutsch, G	1
Denis, L; Mahler, C; Verhelst, J	1
Bonnet, P	1
Chatelain, C; Fourcade, RO	1
Balk, SP; Bubley, GJ; Fenton, MA; Fertig, AM; Kolvenbag, G; Shuster, TD; Taplin, ME	1
Sarosdy, MF	1
De Angelis, M; De Benedetto, G; Migliari, R; Murru, M; Muscas, G; Verdacchi, T	1
Candas, B; Labrie, F	1
Iversen, P; Melezinek, I; Schmidt, A	1
Bennett, CL; Crawford, ED; DeMasi, V; Sartor, O; Schellhammer, PF; Schmitt, B; Wilt, TJ	1
Bishop, TC; Dalton, JT; Kirkovsky, L; Marhefka, CA; Miller, DD; Moore, BM; Mukherjee, A	1
Collette, L; Denis, LJ; Schröder, FH; Studer, UE; Sylvester, RJ	1
Iversen, P; Kolvenbag, GJ; Newling, DW	1
Iversen, P	1
Bennett, CL; Raisch, DW; Sartor, O	1
Dalton, JT; He, Y; Hong, SS; Kirkovsky, L; Marhefka, C; Miller, DD; Perera, MA; Stourman, N; Yin, D	1
Anderson, J	1
Cardi, A; Di Silverio, F; Sciarra, A	1
Baltogiannis, D; Charalabopoulos, K; Giannakopoulos, X; Sofikitis, N	1
Lehtovuori, PT; Nyrönen, TH; Söderholm, AA	1
Davis, NB; Ryan, CW; Stadler, WM; Vogelzang, NJ	1
Chen, JF; Cui, LB; Hong, X; Song, L; Sun, H; Wang, XR; Xu, LC; Xu, XL	1
Boelsterli, UA; Ho, HK; Leow, KY; Zhou, S	1
Agarwal, A; Pahalajani, G; Raina, R; Zippe, C	1
Hara, S; Hyochi, N; Isaacs, JT; Ishioka, J; Kageyama, Y; Kihara, K; Singh, P; Urushibara, M	1
Dong, Z; Lu, S; Wang, A	1
Chapman, RA; Crawford, ED; Eisenberger, MA; Fontana, JA; Hussain, MH; Mills, GM; Parab, M; Raghavan, D; Sartor, AO; Tangen, CM	1
Brower, V	1
Bastide, C; Bruyère, F; Guy, L; Karsenty, G; Rozet, F	1
Cassidy-Bushrow, AE; Haque, R; Keating, NL; Potosky, AL; Tsai, HT; UlcickasYood, M; Van Den Eeden, SK; Xu, X	1
Bryant, AK; Deka, R; McKay, R; Murphy, JD; Nalawade, V; Rose, BS; Sarkar, RR; Simpson, DR	1
Bao, J; He, X; Pan, X; Qi, Y; Shao, G; Zhang, JZH	1

Reviews

26 review(s) available for nilutamide and flutamide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pure antiandrogens as monotherapy in prospective studies of prostatic carcinoma. Progress in clinical and biological research, 1990, Volume: 359 Topics: Androgen Antagonists; Anilides; Animals; Cyproterone; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prospective Studies; Prostatic Neoplasms; Tosyl Compounds	1990
Is there a role for pure antiandrogens in the treatment of advanced prostatic cancer? Progress in clinical and biological research, 1990, Volume: 350 Topics: Aged; Aged, 80 and over; Anilides; Combined Modality Therapy; Diethylstilbestrol; Drug Evaluation; Erectile Dysfunction; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazoles; Imidazolidines; Italy; Libido; Male; Middle Aged; Multicenter Studies as Topic; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Quality of Life; Testosterone	1990
Clinical applications of antiandrogens. Journal of steroid biochemistry, 1988, Volume: 31, Issue:4B Topics: Androgen Antagonists; Breast Neoplasms; Cyproterone; Cyproterone Acetate; Female; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Puberty, Precocious; Skin Diseases; Spironolactone	1988
Androgen blockade and suppression for prostate carcinoma. Lancet (London, England), 1989, Oct-28, Volume: 2, Issue:8670 Topics: Androgen Antagonists; Cyproterone; Drug Administration Schedule; Drug Therapy, Combination; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Pituitary Hormone-Releasing Hormones; Prostatic Neoplasms	1989
Antiandrogenic drugs. Cancer, 1993, Feb-01, Volume: 71, Issue:3 Suppl Topics: Androgen Receptor Antagonists; Anilides; Cyproterone Acetate; Diethylstilbestrol; Drug Administration Schedule; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Megestrol; Megestrol Acetate; Nitriles; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Tosyl Compounds	1993
Antiandrogenic agents as monotherapy in advanced prostatic carcinoma. Cancer, 1993, Feb-01, Volume: 71, Issue:3 Suppl Topics: Androgen Antagonists; Anilides; Antineoplastic Agents; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Neoplasm Staging; Nitriles; Prognosis; Prostatic Neoplasms; Testosterone; Tosyl Compounds	1993
Nilutamide: an antiandrogen for the treatment of prostate cancer. The Annals of pharmacotherapy, 1997, Volume: 31, Issue:1 Topics: Androgen Antagonists; Anilides; Flutamide; Half-Life; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Orchiectomy; Prostatic Neoplasms; Structure-Activity Relationship; Tosyl Compounds	1997
[Conference on the treatment of prostatic cancer. Munich, Germany, 2-3 November 1996]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 1997, Volume: 7, Issue:6 Topics: Androgen Antagonists; Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Flutamide; Humans; Imidazoles; Imidazolidines; Lymph Node Excision; Male; Polymerase Chain Reaction; Prostate; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; Rats	1997
Are non-steroidal anti-androgens appropriate as monotherapy in advanced prostate cancer? European urology, 1998, Volume: 33, Issue:2 Topics: Androgen Antagonists; Anilides; Clinical Trials as Topic; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prostatic Neoplasms; Survival Rate; Tosyl Compounds; Treatment Outcome	1998
Clinical pharmacokinetics of the antiandrogens and their efficacy in prostate cancer. Clinical pharmacokinetics, 1998, Volume: 34, Issue:5 Topics: Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Clinical Trials as Topic; Cyproterone; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prostatic Neoplasms; Tosyl Compounds	1998
The place and the results of monotherapy. Acta urologica Belgica, 1998, Volume: 66, Issue:2 Topics: Androgen Antagonists; Anilides; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prostatic Neoplasms; Tosyl Compounds	1998
Androgen deprivation for prostatic carcinoma: a rationale for choosing components. International journal of urology : official journal of the Japanese Urological Association, 1998, Volume: 5, Issue:4 Topics: Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Flutamide; Goserelin; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prostatic Neoplasms; Tosyl Compounds	1998
Antiandrogens as monotherapy for prostate cancer. European urology, 1998, Volume: 34 Suppl 3 Topics: Androgen Antagonists; Anilides; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prostatic Neoplasms; Tosyl Compounds	1998
Which is the optimal antiandrogen for use in combined androgen blockade of advanced prostate cancer? The transition from a first- to second-generation antiandrogen. Anti-cancer drugs, 1999, Volume: 10, Issue:9 Topics: Androgen Antagonists; Anilides; Antineoplastic Agents; Combined Modality Therapy; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Neoplasm Staging; Nitriles; Orchiectomy; Prostatic Neoplasms; Tosyl Compounds	1999
Antiandrogens: a summary review of pharmacodynamic properties and tolerability in prostate cancer therapy. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 1999, Volume: 71, Issue:5 Topics: Androgen Antagonists; Androgen Receptor Antagonists; Anilides; Antineoplastic Agents, Hormonal; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prostatic Neoplasms; Tosyl Compounds	1999
Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials. Prostate Cancer Trialists' Collaborative Group. Lancet (London, England), 2000, Apr-29, Volume: 355, Issue:9214 Topics: Aged; Androgen Antagonists; Cyproterone; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Orchiectomy; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Survival Analysis	2000
Nonsteroidal antiandrogens: a therapeutic option for patients with advanced prostate cancer who wish to retain sexual interest and function. BJU international, 2001, Volume: 87, Issue:1 Topics: Androgen Antagonists; Anilides; Erectile Dysfunction; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prostatic Neoplasms; Quality of Life; Sexuality; Tosyl Compounds	2001
Combined androgen blockade with nonsteroidal antiandrogens for advanced prostate cancer: a systematic review. Urology, 2001, Volume: 57, Issue:4 Topics: Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Disease-Free Survival; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Orchiectomy; Prostatic Neoplasms	2001
Antiandrogen monotherapy: a new form of treatment for patients with prostate cancer. Urology, 2001, Volume: 58, Issue:2 Suppl 1 Topics: Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Meta-Analysis as Topic; Nitriles; Orchiectomy; Prostatic Neoplasms; Quality of Life; Tosyl Compounds; Treatment Outcome	2001
Antiandrogen monotherapy: indications and results. Urology, 2002, Volume: 60, Issue:3 Suppl 1 Topics: Aged; Androgen Antagonists; Anilides; Castration; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Nitriles; Patient Compliance; Prostatic Neoplasms; Quality of Life; Tosyl Compounds; Treatment Outcome	2002
The role of antiandrogen monotherapy in the treatment of prostate cancer. BJU international, 2003, Volume: 91, Issue:5 Topics: Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Drug Administration Schedule; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Patient Compliance; Prostatic Neoplasms; Survival Analysis; Tosyl Compounds	2003
Antiandrogen monotherapy: recommendations for the treatment of prostate cancer. Urologia internationalis, 2004, Volume: 72, Issue:2 Topics: Androgen Antagonists; Anilides; Chemotherapy, Adjuvant; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Orchiectomy; Prostatic Neoplasms; Quality of Life; Randomized Controlled Trials as Topic; Tosyl Compounds	2004
Monotherapy in advanced prostate cancer: an overview. Experimental oncology, 2004, Volume: 26, Issue:3 Topics: Adenocarcinoma; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Cyproterone Acetate; Dihydrotestosterone; Estrogens; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazolidines; Male; Nitriles; Orchiectomy; Palliative Care; Progesterone Congeners; Prostatic Neoplasms; Randomized Controlled Trials as Topic; Testosterone; Tosyl Compounds	2004
Bioactivation and hepatotoxicity of nitroaromatic drugs. Current drug metabolism, 2006, Volume: 7, Issue:7 Topics: Benzophenones; Biotransformation; Chemical and Drug Induced Liver Injury; Flutamide; Imidazolidines; Nifedipine; Nitro Compounds; Nitrofurantoin; Nitrophenols; Sulfonamides; Tolcapone	2006
[Hormonal treatment in prostate cancer]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 2013, Volume: 23, Issue:15 Topics: Androgen Antagonists; Androgen Receptor Antagonists; Antineoplastic Agents, Hormonal; Benzamides; Combined Modality Therapy; Cyproterone Acetate; Diethylstilbestrol; Estramustine; Estrogens, Non-Steroidal; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazolidines; Male; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Oligopeptides; Phenylthiohydantoin; Prostatectomy; Prostatic Neoplasms	2013

Trials

6 trial(s) available for nilutamide and flutamide

Article	Year
Pure antiandrogens as monotherapy in prospective studies of prostatic carcinoma. Progress in clinical and biological research, 1990, Volume: 359 Topics: Androgen Antagonists; Anilides; Animals; Cyproterone; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Prospective Studies; Prostatic Neoplasms; Tosyl Compounds	1990
Is there a role for pure antiandrogens in the treatment of advanced prostatic cancer? Progress in clinical and biological research, 1990, Volume: 350 Topics: Aged; Aged, 80 and over; Anilides; Combined Modality Therapy; Diethylstilbestrol; Drug Evaluation; Erectile Dysfunction; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazoles; Imidazolidines; Italy; Libido; Male; Middle Aged; Multicenter Studies as Topic; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Quality of Life; Testosterone	1990
[Indications of antiandrogens in benign hyperplasia of the prostate]. Journal d'urologie, 1995, Volume: 101, Issue:2 Topics: Aged; Aged, 80 and over; Androgen Antagonists; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Prostatic Hyperplasia	1995
A phase II study of nilutamide in men with prostate cancer after the failure of flutamide or bicalutamide therapy. BJU international, 2005, Volume: 96, Issue:6 Topics: Adult; Aged; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Disease Progression; Flutamide; Humans; Imidazolidines; Male; Middle Aged; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Tosyl Compounds; Treatment Failure	2005
Long-term effectiveness of luteinizing hormone-releasing hormone agonist or antiandrogen monotherapy in elderly men with localized prostate cancer (T1-2): a retrospective study. Asian journal of andrology, 2007, Volume: 9, Issue:2 Topics: Aged; Aged, 80 and over; Androgen Antagonists; Anilides; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazolidines; Leuprolide; Male; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Retrospective Studies; Tosyl Compounds	2007
Antiandrogen withdrawal in castrate-refractory prostate cancer: a Southwest Oncology Group trial (SWOG 9426). Cancer, 2008, Volume: 112, Issue:11 Topics: Adenocarcinoma; Aged; Aged, 80 and over; Androgen Antagonists; Anilides; Bone Neoplasms; Disease-Free Survival; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazolidines; Male; Middle Aged; Nitriles; Orchiectomy; Prospective Studies; Prostate-Specific Antigen; Prostatic Neoplasms; Substance Withdrawal Syndrome; Survival Rate; Tosyl Compounds	2008

Other Studies

47 other study(ies) available for nilutamide and flutamide

Article	Year
Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. Journal of medicinal chemistry, 2003, Nov-20, Volume: 46, Issue:24 Topics: Androgen Antagonists; Antineoplastic Agents; Binding, Competitive; Cell Line; Doxorubicin; Drug Delivery Systems; Drug Design; Formaldehyde; Humans; Ligands; Microscopy, Fluorescence; Models, Molecular; Prodrugs; Receptors, Androgen	2003
Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera. Journal of medicinal chemistry, 2004, Nov-04, Volume: 47, Issue:23 Topics: Androgen Antagonists; Doxorubicin; Formaldehyde; Green Fluorescent Proteins; Humans; Imidazoles; Ligands; Male; Mannich Bases; Microscopy, Fluorescence; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Structure-Activity Relationship; Tumor Cells, Cultured	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21 Topics: Algorithms; Angiotensin-Converting Enzyme Inhibitors; Animals; CHO Cells; Cricetulus; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Molecular Conformation; Molecular Targeted Therapy; Peptidyl-Dipeptidase A; Receptors, Dopamine D1; Receptors, Dopamine D2; Structure-Activity Relationship; Substrate Specificity	2013
Clinical course of bone metastasis from prostatic cancer following endocrine therapy: examination with bone x-ray. Advances in experimental medicine and biology, 1992, Volume: 324 Topics: Aged; Aged, 80 and over; Bone Neoplasms; Chlormadinone Acetate; Combined Modality Therapy; Estrogens; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Orchiectomy; Osteoblasts; Osteolysis; Osteosclerosis; Prostatic Neoplasms; Radiography; Treatment Outcome	1992
Maximal androgen blockade in prostatic cancer. Scandinavian journal of urology and nephrology. Supplementum, 1991, Volume: 138 Topics: Androgen Antagonists; Buserelin; Flutamide; Goserelin; Humans; Imidazoles; Imidazolidines; Leuprolide; Male; Orchiectomy; Prostatic Neoplasms	1991
Effects of steroidal and non-steroidal antiandrogens on the androgen binding properties of the rat ventral prostate androgen receptor. Biochimica et biophysica acta, 1991, Aug-13, Volume: 1094, Issue:1 Topics: Androgen Antagonists; Animals; Cycloheximide; Flutamide; Imidazoles; Imidazolidines; Kinetics; Male; Prostate; Rats; Receptors, Androgen	1991
Total androgen ablation: American experience. The Urologic clinics of North America, 1991, Volume: 18, Issue:1 Topics: Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazoles; Imidazolidines; Leuprolide; Male; Middle Aged; Orchiectomy; Prostatic Neoplasms	1991
Are organ preservation and maintenance of sexual function compatible with optimal management of prostate cancer? Part 2--Advanced cancer. Progress in clinical and biological research, 1991, Volume: 370 Topics: Androgen Antagonists; Combined Modality Therapy; Erectile Dysfunction; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Prostatic Neoplasms; Testosterone	1991
On the organization of partner preference behavior in female Wistar rats. Physiology & behavior, 1991, Volume: 49, Issue:3 Topics: Androgen Antagonists; Animals; Copulation; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Female; Flutamide; Imidazoles; Imidazolidines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Sex Differentiation; Sexual Behavior, Animal; Sexual Maturation; Social Environment; Testosterone	1991
Carcinoma of the prostate. Guidelines for treatment: the role of antiandrogens. Annals of the New York Academy of Sciences, 1990, Volume: 595 Topics: Androgen Antagonists; Carcinoma; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Prostatic Neoplasms	1990
Effect of a nonsteroidal antiandrogen, anandron, on the reproductive system and fertility in male rats. Contraception, 1990, Volume: 42, Issue:1 Topics: Alkaline Phosphatase; Androgen Antagonists; Animals; Body Weight; Dose-Response Relationship, Drug; Epididymis; Estradiol; Fertility; Flutamide; Fructose; Glycerylphosphorylcholine; Imidazoles; Imidazolidines; Leydig Cells; Male; N-Acetylneuraminic Acid; Organ Size; Phospholipids; Prostate; Proteins; Rats; Rats, Inbred Strains; Seminal Vesicles; Sialic Acids; Spermatogenesis; Testis; Testosterone; Urogenital System	1990
"Casodex" (ICI 176,334)--a new, pure, peripherally-selective anti-androgen: preclinical studies. Hormone research, 1989, Volume: 32 Suppl 1 Topics: Androgen Antagonists; Anilides; Animals; Cyproterone; Cyproterone Acetate; Dogs; Flutamide; Imidazoles; Imidazolidines; Male; Nitriles; Prostatic Neoplasms; Rats; Tosyl Compounds	1989
[Antiandrogens in monotherapy or combined therapy for treatment of advanced cancer of the prostate]. Archivos espanoles de urologia, 1989, Volume: 42 Suppl 2 Topics: Aged; Aged, 80 and over; Androgen Antagonists; Anilides; Antineoplastic Agents; Combined Modality Therapy; Cyproterone; Cyproterone Acetate; Flutamide; Follow-Up Studies; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Neoplasm Staging; Nitriles; Orchiectomy; Prostatic Neoplasms; Tosyl Compounds	1989
[Combined anti-androgen treatment in adenocarcinoma of the prostate: first use of a new therapeutically efficacious principle in hormone-dependent cancer]. Annales d'urologie, 1986, Volume: 20, Issue:2 Topics: Adenocarcinoma; Aged; Androgen Antagonists; Antineoplastic Agents; Drug Therapy, Combination; Flutamide; Gonadotropin-Releasing Hormone; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Neoplasms, Hormone-Dependent; Orchiectomy; Prostatic Neoplasms; Triptorelin Pamoate	1986
Inhibition of rat testicular 17 alpha-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. Journal of steroid biochemistry, 1987, Volume: 28, Issue:1 Topics: Aldehyde-Lyases; Androgen Antagonists; Animals; Cyproterone; Cyproterone Acetate; Cytochrome P-450 Enzyme System; Flutamide; Imidazoles; Imidazolidines; Kinetics; Male; Microsomes; Rats; Rats, Inbred Strains; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Testis	1987
The kinetics of antiandrogens in humans. Progress in clinical and biological research, 1987, Volume: 243A Topics: Androgen Antagonists; Anilides; Cyproterone; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Prostatic Neoplasms	1987
ICI 176,334: a novel non-steroidal, peripherally-selective antiandrogen. Progress in clinical and biological research, 1988, Volume: 260 Topics: Androgen Antagonists; Anilides; Animals; Cyproterone; Cyproterone Acetate; Dogs; Flutamide; Imidazoles; Imidazolidines; Male; Nitriles; Prostate; Radioligand Assay; Rats; Receptors, Androgen; Seminal Vesicles; Testosterone; Tosyl Compounds	1988
Relative effectiveness of alternative androgen withdrawal therapies in initiating regression of rat prostate. The Journal of urology, 1988, Volume: 139, Issue:6 Topics: Anilides; Animals; Cyproterone; Cyproterone Acetate; Diethylstilbestrol; Dihydrotestosterone; Flutamide; Gonadotropin-Releasing Hormone; Imidazoles; Imidazolidines; Leuprolide; Male; Megestrol; Megestrol Acetate; Orchiectomy; Prostate; Rats; Rats, Inbred Strains; Receptors, Androgen	1988
Ocular toxicity of Anandron in patients treated for prostatic cancer. The British journal of ophthalmology, 1986, Volume: 70, Issue:6 Topics: Aged; Androgen Antagonists; Flutamide; Humans; Imidazoles; Imidazolidines; Light; Male; Middle Aged; Prostatic Neoplasms; Vision Disorders; Visual Acuity	1986
Effectiveness of antiandrogens in the rat. The Journal of urology, 1986, Volume: 136, Issue:4 Topics: Androgen Antagonists; Animals; Flutamide; Imidazoles; Imidazolidines; Male; Megestrol; Megestrol Acetate; Orchiectomy; Prostate; Rats; Rats, Inbred Strains; Seminal Vesicles; Testosterone	1986
Pharmacology and clinical studies with RU 23908 (Anandron). Progress in clinical and biological research, 1985, Volume: 185A Topics: Androgen Antagonists; Androstenedione; Animals; Castration; Diethylstilbestrol; Flutamide; Humans; Imidazoles; Imidazolidines; Kinetics; Male; Organ Size; Prostate; Prostatic Neoplasms; Rats	1985
Anti-androgens in treatment of prostate cancer. Lancet (London, England), 1995, Oct-14, Volume: 346, Issue:8981 Topics: Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Cyproterone; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Meta-Analysis as Topic; Prostatic Neoplasms	1995
Androgens induce divergent proliferative responses in human breast cancer cell lines. The Journal of steroid biochemistry and molecular biology, 1995, Volume: 52, Issue:5 Topics: Androgen Receptor Antagonists; Androgens; Breast Neoplasms; Cell Division; Dihydrotestosterone; Flutamide; Humans; Imidazoles; Imidazolidines; Nandrolone; Oligonucleotides, Antisense; Receptors, Androgen; Tumor Cells, Cultured	1995
Antiandrogens inhibit human androgen receptor-dependent gene transcription activation in the human prostate cancer cells LNCaP. The Prostate, 1994, Volume: 24, Issue:4 Topics: Amino Acid Sequence; Androgen Antagonists; Binding, Competitive; Blotting, Western; Chloramphenicol O-Acetyltransferase; Cyproterone Acetate; Dihydrotestosterone; Dose-Response Relationship, Drug; Flutamide; Gene Expression Regulation, Viral; Humans; Imidazoles; Imidazolidines; Male; Mammary Tumor Virus, Mouse; Molecular Sequence Data; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Transcription, Genetic; Transfection; Tumor Cells, Cultured	1994
Interaction of antiandrogen-androgen receptor complexes with DNA and transcription activation. The Journal of steroid biochemistry and molecular biology, 1993, Volume: 46, Issue:6 Topics: Androgen Antagonists; Animals; Binding, Competitive; Blotting, Western; Cell Line; Chloramphenicol O-Acetyltransferase; Chlorocebus aethiops; Cyproterone Acetate; Dihydrotestosterone; DNA; Flutamide; Gene Expression Regulation; Humans; Imidazoles; Imidazolidines; Kidney; Kinetics; Mammary Tumor Virus, Mouse; Metribolone; Receptors, Androgen; Recombinant Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection	1993
Antiandrogen monotherapy in the management of advanced prostate cancer. European urology, 1997, Volume: 31 Suppl 2 Topics: Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Nitriles; Orchiectomy; Palliative Care; Prostatic Neoplasms; Tosyl Compounds	1997
Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. Urology, 1997, Volume: 49, Issue:4 Topics: Androgen Antagonists; Anilides; Animals; Apolipoproteins; Apolipoproteins D; Breast Neoplasms; Carrier Proteins; Cell Division; Dose-Response Relationship, Drug; Flutamide; Glycoproteins; Humans; Imidazoles; Imidazolidines; Membrane Transport Proteins; Mice; Neoplasm Proteins; Nitriles; Tosyl Compounds; Tumor Cells, Cultured	1997
Nilutamide response after flutamide failure in post-orchiectomy progressive prostate cancer. The Journal of urology, 1998, Volume: 159, Issue:3 Topics: Aged; Androgen Antagonists; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Disease Progression; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Orchiectomy; Prostatic Neoplasms; Treatment Failure	1998
Pharmacological profile of RU 58642, a potent systemic antiandrogen for the treatment of androgen-dependent disorders. The Journal of steroid biochemistry and molecular biology, 1998, Volume: 64, Issue:1-2 Topics: Androgen Antagonists; Anilides; Animals; Flutamide; Genital Diseases, Male; Genitalia, Male; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Nitriles; Orchiectomy; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Testosterone; Tosyl Compounds	1998
Functional characterization of mutant androgen receptors from androgen-independent prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:8 Topics: Amino Acid Substitution; Androgen Antagonists; Androgens; Androstenedione; Animals; beta-Galactosidase; Cell Line; Dihydrotestosterone; Estradiol; Flutamide; Genes, Reporter; Imidazoles; Imidazolidines; Luciferases; Male; Point Mutation; Progesterone; Prostatic Neoplasms; Receptors, Androgen; Recombinant Fusion Proteins; Transfection	1997
Androgen blockade in prostate cancer. Lancet (London, England), 2000, Jul-22, Volume: 356, Issue:9226 Topics: Androgen Antagonists; Cyproterone Acetate; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Meta-Analysis as Topic; Orchiectomy; Prostatic Neoplasms	2000
Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands. Journal of medicinal chemistry, 2001, May-24, Volume: 44, Issue:11 Topics: Amino Acid Substitution; Binding Sites; Binding, Competitive; Crystallography, X-Ray; Flutamide; Humans; Imidazoles; Imidazolidines; Ligands; Models, Molecular; Mutation; Protein Conformation; Protein Structure, Tertiary; Receptors, Androgen; Receptors, Progesterone; Stereoisomerism; Structure-Activity Relationship	2001
Why phase III trials of maximal androgen blockade versus castration in M1 prostate cancer rarely show statistically significant differences. The Prostate, 2001, Jun-15, Volume: 48, Issue:1 Topics: Androgen Antagonists; Anilides; Clinical Trials, Phase III as Topic; Cyproterone Acetate; Factor Analysis, Statistical; Flutamide; Gonadotropin-Releasing Hormone; Goserelin; Humans; Imidazoles; Imidazolidines; Leuprolide; Male; Meta-Analysis as Topic; Nitriles; Orchiectomy; Prognosis; Prostatic Neoplasms; Research Design; Survival Analysis; Tosyl Compounds; Treatment Outcome	2001
Pneumonitis associated with nonsteroidal antiandrogens: presumptive evidence of a class effect. Annals of internal medicine, 2002, Oct-01, Volume: 137, Issue:7 Topics: Adult; Aged; Alveolitis, Extrinsic Allergic; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Middle Aged; Nitriles; Prostatic Neoplasms; Tosyl Compounds	2002
Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor. Molecular pharmacology, 2003, Volume: 63, Issue:1 Topics: Anilides; Animals; Cells, Cultured; Flutamide; Haplorhini; Imidazoles; Imidazolidines; Ligands; Nitriles; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Structure-Activity Relationship; Tosyl Compounds; Trail Making Test	2003
Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain. Journal of medicinal chemistry, 2005, Feb-24, Volume: 48, Issue:4 Topics: Anilides; Binding Sites; Flutamide; Imidazolidines; Ligands; Models, Molecular; Nitriles; Quantitative Structure-Activity Relationship; Receptors, Androgen; Tosyl Compounds	2005
Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay. Chemosphere, 2007, Volume: 66, Issue:3 Topics: Androgen Antagonists; Animals; Cell Line; Cell Proliferation; Cell Survival; Dexamethasone; Dihydrotestosterone; Flutamide; Humans; Imidazolidines; Luciferases; Molecular Structure; Nitriles; Permethrin; Pesticides; Pyrethrins; Receptors, Androgen; Recombinant Fusion Proteins; Response Elements; Transfection	2007
Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors. The Prostate, 2007, Jun-01, Volume: 67, Issue:8 Topics: Allylestrenol; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Cyproterone Acetate; Flutamide; Humans; Imidazolidines; Male; Models, Molecular; Mutagenesis, Site-Directed; Neoplasms, Hormone-Dependent; Nitriles; Plasmids; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Testosterone; Tosyl Compounds; Transcription, Genetic; Transfection	2007
A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells. Molecular cancer therapeutics, 2007, Volume: 6, Issue:7 Topics: Androgen Receptor Antagonists; Androgens; Anilides; Antineoplastic Agents; Cell Proliferation; Dihydrotestosterone; Drug Resistance, Neoplasm; Drug Synergism; Flutamide; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Imidazolidines; Male; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Tosyl Compounds; Transcription, Genetic	2007
Watchful waiting beats androgen deprivation therapy in early prostate cancer. Journal of the National Cancer Institute, 2008, Nov-05, Volume: 100, Issue:21 Topics: Aged; Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Buserelin; Drug Prescriptions; Flutamide; Humans; Imidazolidines; Leuprolide; Male; Patient Education as Topic; Patient Satisfaction; Prostatic Neoplasms; Retrospective Studies; Risk Assessment; Risk Factors; Survival Analysis	2008
Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study. British journal of cancer, 2017, Oct-10, Volume: 117, Issue:8 Topics: Aged; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Arrhythmias, Cardiac; California; Cardiovascular Diseases; Cohort Studies; Flutamide; Gonadotropin-Releasing Hormone; Goserelin; Heart Failure; Humans; Imidazolidines; Leuprolide; Male; Middle Aged; Multivariate Analysis; Neoplasm Grading; Nitriles; Proportional Hazards Models; Prospective Studies; Prostatic Neoplasms; Risk Factors; Tosyl Compounds	2017
Androgen deprivation therapy and depression in men with prostate cancer treated with definitive radiation therapy. Cancer, 2019, 04-01, Volume: 125, Issue:7 Topics: Aged; Aged, 80 and over; Ambulatory Care; Androgen Antagonists; Anilides; Antineoplastic Agents, Hormonal; Depression; Depressive Disorder; Flutamide; Gonadotropin-Releasing Hormone; Goserelin; Hospitalization; Humans; Imidazolidines; Leuprolide; Male; Mental Health Services; Middle Aged; Nitriles; Oligopeptides; Prostatic Neoplasms; Radiotherapy; Retrospective Studies; Suicide; Tosyl Compounds	2019
Analysis of the binding modes of the first- and second-generation antiandrogens with respect to F876L mutation. Chemical biology & drug design, 2021, Volume: 98, Issue:1 Topics: Androgen Antagonists; Androgen Receptor Antagonists; Biomarkers, Tumor; Flutamide; Humans; Imidazolidines; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Phenylthiohydantoin; Protein Binding; Protein Conformation; Receptors, Androgen; Structure-Activity Relationship; Thermodynamics; Thiohydantoins	2021