nifurtimox and quindoxin

nifurtimox has been researched along with quindoxin* in 2 studies

Other Studies

2 other study(ies) available for nifurtimox and quindoxin

ArticleYear
Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity.
    Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3

    We report the synthesis and in vitro activity against Trypanosoma cruzi epimastigotes of 15 novel quinoxaline derivatives. Ten of the derivatives presented IC50 values lower than the reference drugs Nfx and Bzn; four of them standed out with IC50 values lower than 1.5 μM. Moreover, unspecific cytotoxicity and genotoxicity studies are also reported. Compound 14 showed a SI higher than 24, whereas compound 10 was the only one that was negative in the genotoxicity screening.

    Topics: Animals; Cell Survival; Chlorocebus aethiops; Nitrogen; Oxides; Quinoxalines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2016
Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2-carbonitrile di-N-oxides.
    Bioorganic & medicinal chemistry letters, 2010, Aug-15, Volume: 20, Issue:16

    In a continuing effort to identify new active compounds for combating Chagas disease and other neglected diseases, our research group synthesized and evaluated 23 3-arylquinoxaline-2-carbonitrile di-N-oxides against Trypanosoma cruzi. Five of them presented IC(50) values of the same magnitude as the standard drug Nifurtimox, making them valid as new lead compounds. The optimized molecular structures of 23 derivatives represented by 1497 types of DRAGON descriptors were subjected to linear regression analysis, and the derived QSAR was shown to be predictive. In this way, we achieved a rational guide for the proposal of new candidate structures whose activities still remain unknown.

    Topics: Nifurtimox; Oxides; Quantitative Structure-Activity Relationship; Quinoxalines; Trypanocidal Agents; Trypanosoma cruzi

2010