nifurtimox has been researched along with harman* in 1 studies
1 other study(ies) available for nifurtimox and harman
| Article | Year |
|---|---|
Effects of some beta-carboline alkaloids on intact Trypanosoma cruzi epimastigotes.
Several beta-carboline (9H-pyrido-[3,4-b]-indole) alkaloids were evaluated for in vitro trypanosomicidal activity against Trypanosoma cruzi epimastigotes belonging to two different strains (Tulahuén and LQ) showing different sensitivity to nifurtimox. Important differences were observed in the susceptibility of the parasites to these natural substances, with the relatively nifurtimox-resistant LQ strain showing greater sensitivity to the beta-carbolines. Respiratory chain inhibition appears to be a possible determinant of the trypanosomicidal activity of these compounds. Topics: Animals; Carbolines; Harmaline; Harmine; Kinetics; Nifurtimox; Oxygen Consumption; Species Specificity; Trypanocidal Agents; Trypanosoma cruzi | 1999 |