nifuroxazide has been researched along with benzonidazole* in 1 studies
1 other study(ies) available for nifuroxazide and benzonidazole
| Article | Year |
|---|---|
Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T. cruzi agents.
In this study, in vitro anti-T. cruzi activity assays of nifuroxazide (NX) analogues, such as 5-nitro-2-furfuryliden and 5-nitro-2-theniliden derivatives, were performed. A molecular modeling approach was also carried out to relate the lipophilicity potential (LP) property and biological activity data. The majority of the NX derivatives showed increased anti-T. cruzi activity in comparison to the reference drug, benznidazole (BZN). Additionally, the 5-nitro-2-furfuryliden derivatives presented better pharmacological profile than the 5-nitro-2-theniliden analogues. The LP maps and corresponding ClogP values indicate that there is an optimum lipophilicity value, which must be observed in the design of new potential anti-T. cruzi agents. Topics: Animals; Hydroxybenzoates; Models, Molecular; Nitrofurans; Nitroimidazoles; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2009 |