nifuroxazide and 4-hydroxybenzoic-acid-hydrazide

nifuroxazide has been researched along with 4-hydroxybenzoic-acid-hydrazide* in 2 studies

Other Studies

2 other study(ies) available for nifuroxazide and 4-hydroxybenzoic-acid-hydrazide

ArticleYear
Hapten synthesis, monoclonal antibody production and immunoassay development for direct detection of 4-hydroxybenzehydrazide in chicken, the metabolite of nifuroxazide.
    Food chemistry, 2021, Sep-01, Volume: 355

    Derivatization is usually employed in immunoassay for detection of metabolites of nitrofurans and avoiding derivatization could be preferable to achieve an efficient screening. In the study, we designed four haptens of 4-hydroxybenhydrazide (HBH), the nifuroxazide metabolite. The effect of hapten structures on antibody affinity were evaluated and one monoclonal antibody was produced by using the Hapten C with a linear alkalane spacer arm. After optimization, an enzyme linked-immunosorbent assay (ELISA) was established with an 50% inhibition concentration of 0.25 ng mL

    Topics: Animals; Antibodies, Monoclonal; Antibody Formation; Chickens; Enzyme-Linked Immunosorbent Assay; Haptens; Hydrogen-Ion Concentration; Hydroxybenzoates; Mice; Nitrofurans; Osmolar Concentration; Temperature

2021
Residue depletion of nifuroxazide in broiler chicken.
    Journal of the science of food and agriculture, 2013, Volume: 93, Issue:9

    Several nitrofuran drugs have been prohibited for use in food producing animals due to their carcinogenic and mutagenic effects. However, one of the nitrofurans, nifuroxazide, is still used as a veterinary drug in some countries. This study was conducted to investigate the residue depletion of nifuroxazide in broiler chicken. Chickens were fed with dietary feeds containing 50 mg kg⁻¹ of nifuroxazide for seven consecutive days. Liver, kidney, muscle and plasma samples were collected at different withdrawal periods, and the residues of parent nifuroxazide and its acid-hydrolysable side chain, 4-hydroxybenzhydrazide (HBH), in these samples were determined.. Nifuroxazide was metabolised in vivo and its metabolite HBH was formed. Parent nifuroxazide was not detectable in these samples after 14 days of cessation. HBH was detectable in these samples even after 28 days of cessation and the total HBH residues were higher than 1.0 ng g⁻¹. Furthermore, the residue level of tissue bound HBH was much higher than that of free HBH.. The tissue-bound HBH could be used as a marker to monitor the residue of nifuroxazide in chicken and the best target tissue should be liver. This is the first paper reporting the residue depletion of nifuroxazide in chicken.

    Topics: Animals; Anti-Infective Agents; Biomarkers; Biotransformation; Chickens; China; Drug Residues; Food Additives; Food Contamination; Hydroxybenzoates; Kidney; Liver; Meat; Muscle, Skeletal; Nitrofurans; Random Allocation; Tissue Distribution; Veterinary Drugs

2013