Page last updated: 2024-09-03

nifekalant hydrochloride and pyrimidinones

nifekalant hydrochloride has been researched along with pyrimidinones in 123 studies

Compound Research Comparison

Studies (nifekalant hydrochloride)	Trials (nifekalant hydrochloride)	Recent Studies (post-2010) (nifekalant hydrochloride)	Studies (pyrimidinones)	Trials (pyrimidinones)	Recent Studies (post-2010) (pyrimidinones)
138	16	38	6,059	604	2,692

Research

Studies (123)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	29 (23.58)	18.2507
2000's	55 (44.72)	29.6817
2010's	34 (27.64)	24.3611
2020's	5 (4.07)	2.80

Authors

Authors	Studies
Ishii, M; Kamiya, J; Katakami, T	1
Awaji, T; Haruno, A; Hashimoto, K; Hirasawa, A; Wu, Z; Xue, Y	1
Black, SC; Chi, L; Friedrichs, GS; Lucchesi, BR; Manley, PJ	1
Hashimoto, H; Kondoh, K; Nakashima, M; Nishiyama, H; Ozaki, T; Uematsu, T; Umemura, K	1
Aida, Y; Hisatome, I; Karasaki, S; Katori, R; Koumi, S; Mashiba, H; Oyaizu, M; Sato, R; Takai, H	1
Kanno, M; Nakaya, H; Takeda, Y; Tohse, N	1
Kanno, M; Nakaya, H; Tohse, N	1
Basler, GC; Black, SC; Chi, L; Friedrichs, GS; Gralinski, MR; Johnson, CR; Lucchesi, BR; Mu, DX; Pewitt, SR	1
Hara, Y; Masuda, Y; Mori, K; Nakaya, H; Saito, T	1
Ishii, K; Taira, N; Yamagishi, T	1
Mitamura, H; Ogawa, S; Okada, Y; Sadanaga, T	1
Bursill, JA; Campbell, TJ; Martin, DK; Nakaya, Y; West, PD; Wyse, KR	1
Centurion, OA; Hayano, M; Hirata, T; Isomoto, S; Kaibara, M; Konoe, A; Yano, K	1
Hashimoto, K; Motomura, S; Yamada, A	1
Endou, M; Hara, Y; Mori, K; Nakaya, H; Uemura, H	1
Cheng, J; Kamiya, K; Kodama, I; Toyama, J	1
Masuda, Y; Mori, K; Nakaya, H; Saito, T	1
Chen, J; Hashimoto, K; Komori, S; Li, B; Tamura, K	1
Kanese, Y; Murakawa, Y; Omata, M; Yamashita, T	2
Fujiki, A; Hayashi, H; Inoue, H; Tani, M; Usui, M	1
Endo, M; Kasanuki, H; Koyanagi, H; Nishida, H; Ohnishi, S; Tomizawa, Y; Uwabe, K	1
Cui, G; Sakaguchi, Y; Sen, L; Singh, BN	1
Aizawa, Y; Naitoh, N; Takahashi, K; Washizuka, T	1
Aizawa, Y; Furushima, H; Naitoh, N; Tagawa, M; Taneda, K; Yamaura, M	2
Aye, NN; Hashimoto, K; Xue, Y; Yamada, C	1
Furukawa, T; Koyama, Y; Nishimura, M; Sagawa, T; Suzuki, K; Yamanaka, M	1
Aikawa, M; Handa, S; Iwamoto, T; Iwata, O; Kusuzaki, S; Mori, H; Shinozaki, Y; Tanabe, T	1
Kanmatuse, K; Kojima, T; Kunimoto, S; Masaki, R; Nakai, T; Oshikawa, N; Ozawa, Y; Saito, S; Watanabe, H; Watanabe, I	1
Daikoku, S; Kamakura, S; Kurita, T; Miyazaki, S; Morii, I; Nonogi, H; Sutani, Y; Takenaka, K; Yasuda, S	1
Ando, S; Kasanuki, H; Matsuda, N; Shiga, T; Suzuki, T	1
Ishiwata, S; Iwase, T; Koizumi, T; Komiyama, N; Komuro, I; Momomura, S; Nakanishi, S; Nishiyama, S; Tanigawa, T	1
Oyabe, A; Sano, H	1
Fuda, Y; Hagiwara, N; Haruta, S; Kasanuki, H; Matsuda, N; Shiga, T	1
Ohnishi, S	1
Aonuma, K; Hiraoka, M; Hiroe, M; Igawa, M; Isobe, M; Okamoto, Y	1
Komuro, I; Kushida, S; Nakaya, H; Ogura, T	1
Ito, H; Maruyama, T	1
Amino, M; Ban, K; Deguchi, Y; Fujikura, H; Goto, S; Handa, S; Inokuchi, S; Iwase, H; Iwata, O; Marutani, Y; Morita, S; Nakagawa, Y; Shiina, Y; Tanabe, T; Yamamoto, I; Yoshioka, K	1
Aoyagi, T; Fukushima, K; Kobayakawa, N; Otani, Y; Sawaki, D; Sekita, G; Takeuchi, H	1
Fu, LT; Iinuma, H; Sagara, K; Sahara, M; Watanabe, H; Yamashita, T	1
Hashimoto, K	1
Kamakura, S; Kawamura, A; Kurita, T; Miyazaki, S; Morii, I; Myoishi, M; Nonogi, H; Otsuka, Y; Satomi, K; Ueno, K; Yasuda, S	1
Centurion, OA; Fukae, S; Isomoto, S; Komiya, N; Minami, T; Nakao, K; Yano, K	1
Iwasa, S; Sakaguchi, M; Shimamura, Y; Takemura, T; Tsuda, Y	1
Chiba, K; Hashimoto, K; Satoh, Y; Sugiyama, A; Takahara, A	1
Hashimoto, K; Noda, Y	1
Hotoda, K; Kokaji, K; Kumamaru, H; Okamoto, M	1
Bando, K; Okamura, H; Ueda, HI	1
Fujino, T; Igarashi, M; Kobayashi, K; Koyama, N; Okano, Y; Otsuka, T; Sasamoto, S; Sasao, K; Sugino, K; Toyoda, M; Yosiwara, K	1
Aoki, K; Asakura, T; Enomoto, Y; Furuta, S; Inai, Y; Toshimitsu, Y	1
Amino, M; Honjo, H; Horiba, M; Kamiya, K; Kodama, I; Lee, JK; Nakagawa, H; Okuno, Y; Tanabe, T; Yamazaki, M; Yasui, K; Yoshioka, K	1
Kofune, T; Masaki, R; Okubo, K; Okumura, Y; Saito, S; Shindo, A; Watanabe, I	1
Endo, H; Hirose, M; Kagaya, Y; Miura, M; Shirato, K; Stuyvers, BD; Sugai, Y; ter Keurs, HE; Wakayama, Y; Watanabe, J	1
Hayashi, M; Kato, T; Kobayashi, Y; Morita, N; Sato, N; Takano, T; Tanaka, K; Yasutake, M	1
Ando, J; Iwabuchi, M; Kakishita, M; Komura, Y; Nishiyama, K; Nobuyoshi, M; Nosaka, H; Sakai, K; Yasumoto, H; Yokoi, H	1
Kasanuki, H; Katoh, T; Matsuda, N; Mitamura, H; Ogawa, S; Takano, T	1
Honjo, H; Ishiguro, Y; Kamiya, K; Kodama, I; Nakagawa, H; Okuno, Y; Sakuma, I; Yamazaki, M	1
Aizawa, Y; Chinushi, M; Furushima, H; Hirono, T; Hosaka, Y; Komura, S; Sugiura, H; Tanabe, Y; Washizuka, T; Watanabe, H	2
Amino, M; Deguchi, Y; Ikari, Y; Inokuchi, S; Kodama, I; Matsuzaki, A; Morita, S; Nakagawa, Y; Sugimoto, A; Tanabe, T; Usui, K; Yamamoto, I; Yoshioka, K	1
Hamano, K; Murakami, M; Nishida, M; Okada, H	1
Fujiki, A	1
Hayashida, A; Maruyama, T	1
Ebina, T; Hibi, K; Kimura, K; Kosuge, M; Kosuge, T; Moriwaki, Y; Sugiyama, M; Sumita, S; Suzuki, N; Tahara, Y; Toyama, H; Umemura, S	1
Sugi, K	1
Endo, H; Hirose, M; Kagaya, Y; Miura, M; Nakano, M; Shimokawa, H; Shirato, K; Sugai, Y; Takahashi, J; Wakayama, Y; Watanabe, J	1
Arakaki, T; Isomoto, S; Kawakami, A; Ono, K; Yamashita, S; Yano, K	1
Amino, M; Honjo, H; Ishiguro, YS; Kamiya, K; Kodama, I; Nakagawa, H; Okuno, Y; Sakuma, I; Yamazaki, M	1
Amino, M; Deguchi, Y; Ikari, Y; Kanda, S; Kodama, I; Kohzuma, K; Matsuzaki, A; Sugimoto, A; Tanabe, T; Usui, K; Yoshioka, K	1
Hua, W; Huang, CX; Sun, Q; Tang, M; Zhang, S	1
Kamakura, S; Kawamura, A; Kurita, T; Miyazaki, S; Morii, I; Nonogi, H; Ohashi, J; Shimizu, W; Yasuda, S	1
Hashimoto, K; Nakamura, H; Nouchi, H; Shigenobu, K; Shimada, H; Sugiyama, A; Takahara, A; Takeda, K; Tamura, M; Tamura, T; Tanaka, H; Tanaka, T; Tsuruoka, N	1
Kato, H; Makino, Y; Murakami, T	1
Homma, M; Inoue, J; Kato, H; Murata, K; Ogasawara, T; Takeuchi, S	1
Akutsu, K; Hayashi, M; Katoh, T; Kobayashi, Y; Morita, N; Satoh, N; Takano, T; Tanaka, K; Yamamoto, T; Yodogawa, K	1
Katayama, H; Katsumata, T; Kishida, H; Nemoto, S; Okumura, K; Ozaki, N; Ozawa, H; Sasaki, T; Tamai, H	1
Fukuhara, S; Makino, K; Morimoto, A; Nakagawa, Y; Takase, E; Tateishi, E; Umeda, M; Yamamoto, K; Yokoyama, K	1
Azegami, K; Hirao, K; Isobe, M; Miyagi, N; Nakamura, K; Ohba, K; Okishige, K; Shimabukuro, M; Uehara, H; Wakimoto, H	1
Ajiki, K; Hayami, N; Inaba, H; Kunishima, T; Murakawa, Y; Sugishita, Y; Yamagishi, N; Yamagishi, S	1
Maeda, K; Nakagawa, E; Takagi, M; Tatsumi, H; Yoshiyama, M	1
Enjoji, Y; Funatsu, A; Kambayashi, D; Kobayashi, T; Mizobuchi, M; Nakamura, S; Ono, T; Yamamoto, R	1
Abe, A; Ikeda, T; Ishiguro, H; Mera, H; Miwa, Y; Miyakoshi, M; Shimizu, H; Tsukada, T; Yoshino, H; Yusu, S	1
Amino, M; Honda, T; Kasanuki, H; Kato, R; Katoh, T; Matsudo, Y; Ogawa, S; Sagara, K; Shiga, T; Takahashi, A; Takano, T; Tanaka, K; Urashima, M	1
Akieda, K; Amino, M; Fujibayashi, D; Fukushima, T; Hashida, T; Higami, S; Inokuchi, S; Kodama, I; Morita, S; Opthof, T; Otsuka, H; Shima, M; Tamura, K; Tanabe, T; Uemura, S; Yoshioka, K	1
Kurose, Y; Minami, I; Nakatsuji, N; Otsuji, TG; Tada, M; Yamauchi, K	1
Hisahara, M; Ikeuchi, M; Kozai, T; Kurisu, K; Onitsuka, H; Sekiya, M; Urabe, Y	1
Cong, LH; Ji, XF; Li, CS; Wang, S; Yang, L	1
Chen, KP; Hua, W; Pu, JL; Wang, FZ; Wang, J; Yang, YM; Zhang, S; Zhu, J	1
Hazui, H; Kada, A; Nonogi, H; Ohashi, J; Sase, K; Sawano, H; Ukai, I; Yasuda, S; Yokoyama, H	1
Aono, H; Furukawa, H; Iwasaki, K; Ohkado, A; Samukawa, M	1
Nagao, K	1
Ajiki, K; Hayami, N; Inaba, H; Kunishima, T; Mikamo, T; Murakawa, Y; Sugiura, A; Tsutsui, K; Watanabe, H; Yamagishi, N; Yamagishi, S	1
Hirayama, A; Kasamaki, Y; Kofune, M; Kunimoto, S; Mano, H; Nagashima, K; Ohkubo, K; Okumura, Y; Sonoda, K; Watanabe, I	1
Furutani, K; Inanobe, A; Iwata, M; Kurachi, Y; Ohno, Y; Yamakawa, Y	1
Chinushi, M; Furushima, H; Izumi, D; Sato, A	1
Fujii, M; Imaizumi, Y; Ohya, S; Yamamura, H	1
Hirayama, A; Kofune, M; Mano, H; Nagashima, K; Ohkubo, K; Okumura, Y; Sonoda, K; Watanabe, I	1
Ajiki, K; Hayami, N; Kanamori, K; Kunishima, T; Mikamo, T; Murakawa, Y; Sugiura, A; Tsutsui, K; Watanabe, H; Yamagishi, N; Yamagishi, S	1
Kumagai, K; Toyama, H	1
Jiang, XH; Liu, XM; Wang, L; Zhou, Y	1
Hoshiyama, T; Kanazawa, H; Koyama, J; Morihisa, K; Ogawa, H; Tanaka, Y; Uemura, T; Yamabe, H	1
An, Y; Shi, G; Sui, Y; Tang, Y; Yan, M; Zhang, M	1
Hirayama, A; Kofune, M; Kogawa, R; Mano, H; Nakai, T; Ohkubo, K; Okumura, Y; Sasaki, N; Sonoda, K; Watanabe, I	1
Aibara, K; Goto, K; Harayama, N; Isa, Y; Kamochi, M; Nagata, K; Nihei, S; Sata, T	1
Ando, K; Kazusa, K; Nakamura, Y; Sugiyama, A; Watanabe, Y	1
Iacovidou, N; Karlis, G; Lelovas, P; Mentzelopoulos, S; Niforopoulou, P; Papalois, A; Siafaka, I; Xanthos, T	1
Amino, M; Funakoshi, H; Hayakawa, K; Ikari, Y; Inokuchi, S; Matsuzaki, M; Morimura, N; Nagao, K; Nakagawa, Y; Sakurai, A; Tahara, Y; Yaguchi, A; Yonemoto, N; Yoshioka, K	1
Aibara, K; Harayama, N; Kamochi, M; Nagata, K; Nihei, S; Sata, T	1
Fukuda, R; Fushimi, K; Ishinokami, S; Kitahashi, A; Matsui, H; Oyanagi, M; Tagami, T; Unemoto, K; Yasunaga, H	1
Koyfman, A; Long, B	1
Tagami, T; Yasunaga, H; Yokota, H	1
Chuma, M; Imai, T; Ishizawa, K; Izawa-Ishizawa, Y; Koga, T; Kondo, Y; Koyama, T; Kurata, Y; Nakura, H; Niimura, T; Sato, S; Sendo, T; Takechi, K; Tanaka, S; Zamami, Y	1
Furue, M; Ichiki, T; Mitoma, C; Mukai, Y; Nakahara, T; Nishizaki, A; Uchi, H; Wada, M; Yasukouchi, Y	1
Chiba, K; Ishizaka, T; Maeda, Y; Mori, K; Yoshimatsu, Y	1
Chen, IS; Furutani, K; Handa, K; Kurachi, Y; Sack, JT; Tsumoto, K; Yamakawa, Y	1
Bao, H; Chen, Q; Cheng, X; Fan, S; Hong, K; Hu, J; Huang, L; Huang, Q; Ju, Z; Li, J; Marian, AJ; Wu, Y; Xia, Z; Xiong, Q; You, C; Yu, J; Yuan, P; Zhu, B	1
Kubota, T; Okura, H; Takasugi, N	1
Han, Y; Huo, H; Liu, Y; Tang, Y; Zan, Y; Zhang, J	1
Chen, Q; Hong, K; Hu, J; Li, J; Wu, Y; Xia, Z; Xiong, Q; Yu, J; Zhai, Z; Zhu, B	1
Di, C; Gao, P; Lin, W; Wang, Q; Wu, Y	1
Chen, Q; Tao, L; Xiao, H	1

Reviews

12 review(s) available for nifekalant hydrochloride and pyrimidinones

Article	Year
[Pharmacological and clinical profile of nifekalant (shinbit injection), a class III antiarrhythmic drug]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 119, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Humans; Male; Pyrimidinones	2002
[Management of lethal ventricular arrhythmias after cardiac surgery]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:7 Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Catheter Ablation; Humans; Intra-Aortic Balloon Pumping; Postoperative Complications; Pyrimidinones; Recurrence; Tachycardia, Ventricular; Ventricular Fibrillation	2002
[Recent findings on the dromotropic actions of the class III antiarrhythmic agents]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 120, Issue:5 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Neural Conduction; Pyrimidinones; Sotalol	2002
[Preclinical evaluation of drug induced QT prolongation]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2003, Volume: 121, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Drug Design; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyrimidinones; Torsades de Pointes	2003
Optical imaging of spiral waves: pharmacological modification of spiral-type excitations in a 2-dimensional layer of ventricular myocardium. Journal of electrocardiology, 2005, Volume: 38, Issue:4 Suppl Topics: Amiodarone; Animals; Anisotropy; Anti-Arrhythmia Agents; Heart Conduction System; Humans; Myocardium; Pre-Excitation Syndromes; Pyrimidinones; Signal Processing, Computer-Assisted; Sodium Channel Blockers; Tachycardia, Ventricular	2005
[Present status in and prospects for anti-arrhythmic drug therapy: How to use type III anti-arrhythmic agents]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2006, Feb-10, Volume: 95, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Drug Therapy, Combination; Humans; Pyrimidinones; Sotalol	2006
[Electrical propagation in cardiac muscle and its modulation by potassium channels and potassium channel modulators]. Fukuoka igaku zasshi = Hukuoka acta medica, 2005, Volume: 96, Issue:12 Topics: Animals; Anti-Asthmatic Agents; Electric Conductivity; In Vitro Techniques; Membrane Potentials; Models, Theoretical; Myocytes, Cardiac; Potassium Channel Blockers; Potassium Channels; Pyrimidinones	2005
[Strategy for cardiac arrhythmias in acute coronary syndrome]. Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64, Issue:4 Topics: Amiodarone; Angina, Unstable; Anti-Asthmatic Agents; Aprindine; Atrial Fibrillation; Bepridil; Electric Countershock; Humans; Myocardial Infarction; Potassium Channel Blockers; Pyrimidinones; Recurrence; Syndrome; Tachycardia, Ventricular; Ventricular Fibrillation	2006
[Drug Therapy for Shock-Resistant Ventricular Fibrillation: Comparison of Nifekalant and Amiodarone]. Journal of UOEH, 2016, Mar-01, Volume: 38, Issue:1 Topics: Amiodarone; Anti-Asthmatic Agents; Defibrillators; Humans; Injections, Intravenous; Potassium Channel Blockers; Pyrimidinones; Ventricular Fibrillation	2016
Best Clinical Practice: Emergency Medicine Management of Stable Monomorphic Ventricular Tachycardia. The Journal of emergency medicine, 2017, Volume: 52, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Electric Countershock; Electrocardiography; Emergency Service, Hospital; Evidence-Based Medicine; Humans; Lidocaine; Procainamide; Pyrimidinones; Review Literature as Topic; Sotalol; Tachycardia, Ventricular	2017
Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation. Critical care (London, England), 2017, Mar-21, Volume: 21, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Emergency Medical Services; Humans; Intensive Care Units; Lidocaine; Out-of-Hospital Cardiac Arrest; Placebos; Pyrimidinones; Ventricular Fibrillation	2017
Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia. Scientific reports, 2017, 10-04, Volume: 7, Issue:1 Topics: Amiodarone; Humans; Publication Bias; Pulse; Pyrimidinones; Randomized Controlled Trials as Topic; Survival Analysis; Tachycardia, Ventricular; Treatment Outcome; Ventricular Fibrillation	2017

Trials

16 trial(s) available for nifekalant hydrochloride and pyrimidinones

Article	Year
Assessment of reverse use-dependent blocking actions of class III antiarrhythmic drugs by 24-hour Holter electrocardiography. Journal of the American College of Cardiology, 1996, Volume: 27, Issue:1 Topics: Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Male; Middle Aged; Phenethylamines; Piperidines; Pyridines; Pyrimidinones; Regression Analysis; Sotalol; Statistics, Nonparametric; Sulfonamides	1996
Anti-arrhythmic efficacy of nifekalant hydrochloride, a pure class III anti-arrhythmic agent, in patients with healed myocardial infarction and inducible sustained ventricular tachycardia. Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:5 Topics: Adult; Aged; Anti-Arrhythmia Agents; Electrocardiography; Electrophysiology; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Procainamide; Pyrimidinones; Tachycardia, Ventricular	2002
[The efficiency of nifekalant hydrochloride for the prevention of ventricular tachycardia during cardiac surgery]. Kyobu geka. The Japanese journal of thoracic surgery, 2004, Volume: 57, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Surgical Procedures; Female; Humans; Infusions, Intravenous; Intraoperative Complications; Male; Middle Aged; Postoperative Complications; Pyrimidinones; Tachycardia, Ventricular; Treatment Outcome	2004
Enhancing electrical cardioversion and preventing immediate reinitiation of hemodynamically deleterious atrial fibrillation with class III drug pretreatment. Journal of cardiovascular electrophysiology, 2005, Volume: 16, Issue:7 Topics: Aged; Aging; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Female; Hemodynamics; Hospital Mortality; Humans; Male; Middle Aged; Premedication; Prognosis; Pyrimidinones; Secondary Prevention; Treatment Failure; Treatment Outcome	2005
Nifekalant hydrochloride suppresses severe electrical storm in patients with malignant ventricular tachyarrhythmias. Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:12 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Defibrillators, Implantable; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pyrimidinones; Salvage Therapy; Tachycardia, Ventricular	2005
Can nifekalant hydrochloride be used as a first-line drug for cardiopulmonary arrest (CPA)? : comparative study of out-of-hospital CPA with acidosis and in-hospital CPA without acidosis. Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:1 Topics: Acidosis; Aged; Anti-Arrhythmia Agents; Electric Countershock; Epinephrine; Female; Heart Arrest; Humans; Hydrogen-Ion Concentration; Inpatients; Male; Middle Aged; Outpatients; Potassium; Pyrimidinones; Resuscitation; Retrospective Studies; Tachycardia, Ventricular	2006
Comparison of efficacy of sotalol and nifekalant for ventricular tachyarrhythmias. Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:5 Topics: Adult; Aged; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Heart Diseases; Humans; Male; Middle Aged; Pyrimidinones; Secondary Prevention; Sotalol; Tachycardia, Ventricular; Treatment Outcome	2006
Prevention of life-threatening ventricular tachyarrhythmia by a novel and pure class-III agent, nifekalant hydrochloride. Journal of cardiovascular pharmacology, 2006, Volume: 48, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Pyrimidinones; Risk Factors; Treatment Outcome; Ventricular Fibrillation	2006
Clinical study of the acute effects of intravenous nifekalant on the defibrillation threshold in patients with persistent and paroxysmal atrial fibrillation. Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:1 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Electric Countershock; Female; Humans; Male; Middle Aged; Pyrimidinones; Treatment Outcome	2008
The effects of nifekalant hydrochloride on the QT dispersion after direct-current defibrillation. Osaka city medical journal, 2008, Volume: 54, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Electrocardiography; Female; Humans; Male; Middle Aged; Pyrimidinones; Sotalol; Tachycardia, Ventricular; Ventricular Fibrillation; Ventricular Function, Left	2008
Effects of intravenous nifekalant as a lifesaving drug for severe ventricular tachyarrhythmias complicating acute coronary syndrome. Circulation journal : official journal of the Japanese Circulation Society, 2009, Volume: 73, Issue:11 Topics: Acute Coronary Syndrome; Aged; Amiodarone; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Emergency Medical Services; Female; Heart Rate; Humans; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Male; Middle Aged; Pyrimidinones; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Fibrillation	2009
Comparative study of nifekalant versus amiodarone for shock-resistant ventricular fibrillation in out-of-hospital cardiopulmonary arrest patients. Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:4 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electric Countershock; Emergency Service, Hospital; Female; Heart Arrest; Heart Diseases; Humans; Male; Middle Aged; Prognosis; Pyrimidinones; Survival Analysis; Treatment Outcome; Ventricular Fibrillation	2010
Nifekalant hydrochloride terminating sustained ventricular tachycardia accompanied with QT dispersion prolongation. Chinese medical journal, 2010, Aug-05, Volume: 123, Issue:15 Topics: Adult; Anti-Arrhythmia Agents; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Pyrimidinones; Tachycardia, Ventricular; Treatment Outcome	2010
Usefulness of ablation of complex fractionated atrial electrograms using nifekalant in persistent atrial fibrillation. Journal of cardiology, 2013, Volume: 61, Issue:1 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Combined Modality Therapy; Electrocardiography; Female; Humans; Male; Middle Aged; Prospective Studies; Pyrimidinones; Treatment Outcome	2013
Population pharmacokinetic/pharmacodynamic modelling of nifekalant in healthy Chinese volunteers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Aug-01, Volume: 151 Topics: China; Chromatography, Liquid; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Models, Biological; Pyrimidinones; Tandem Mass Spectrometry	2020
Comparison of the efficacy and safety of different doses of nifekalant in the instant cardioversion of persistent atrial fibrillation during radiofrequency ablation. Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:3 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Electrocardiography; Female; Humans; Male; Middle Aged; Pyrimidinones; Radiofrequency Ablation	2021

Other Studies

95 other study(ies) available for nifekalant hydrochloride and pyrimidinones

Article	Year
Antiarrhythmic effects of MS-551, a new class III antiarrhythmic agent, on canine models of ventricular arrhythmia. Japanese journal of pharmacology, 1992, Volume: 58, Issue:2 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Digitalis Glycosides; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Female; Heart Rate; Injections, Intravenous; Male; Pyrimidinones; Tachycardia	1992
Effects of the new class III antiarrhythmic drug MS-551 and d-sotalol on canine coronary ligation-reperfusion ventricular arrhythmias. Japanese journal of pharmacology, 1995, Volume: 68, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Dogs; Female; Halothane; Ligation; Male; Myocardial Reperfusion; Pentobarbital; Pyrimidinones; Sotalol; Ventricular Fibrillation	1995
Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Guanidines; Heart; Heart Atria; Hypoxia; In Vitro Techniques; Pinacidil; Pyrimidinones; Rabbits; Vasodilator Agents; Ventricular Fibrillation	1994
Effects of MS-551, a new class III antiarrhythmic drug, on programmed stimulation-induced ventricular arrhythmias, electrophysiology, and hemodynamics in a canine myocardial infarction model. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Electrocardiography; Hemodynamics; Myocardial Infarction; Pyrimidinones; Refractory Period, Electrophysiological; Tachycardia, Ventricular	1994
A new class III antiarrhythmic drug, MS-551, blocks the inward rectifier potassium channel in isolated guinea pig ventricular myocytes. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyrimidinones; Ventricular Function	1995
Effects of MS-551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes. British journal of pharmacology, 1993, Volume: 109, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cell Membrane; Electric Stimulation; Heart; Heart Rate; Heart Ventricles; In Vitro Techniques; Ion Channels; Membrane Potentials; Myocardial Contraction; Myocardium; Papillary Muscles; Potassium Channels; Pyrimidinones; Rabbits; Refractory Period, Electrophysiological; Sotalol	1993
[Electropharmacological properties of class III antiarrhythmic drugs]. Japanese circulation journal, 1994, Volume: 58 Suppl 4 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Heart; In Vitro Techniques; Piperidines; Pyridines; Pyrimidinones; Rabbits	1994
MS-551 protects against ventricular fibrillation in a chronic canine model of sudden cardiac death. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Death, Sudden, Cardiac; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography; Electrophysiology; Male; Myocardial Infarction; Pyrimidinones; Random Allocation; Ventricular Fibrillation	1995
Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells. Different molecular mechanisms. Circulation, 1995, Jun-01, Volume: 91, Issue:11 Topics: Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Atrial Function, Left; Cells, Cultured; Guinea Pigs; Heart Atria; In Vitro Techniques; Myocardial Contraction; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Receptors, Muscarinic; Sotalol	1995
Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels. Japanese journal of pharmacology, 1993, Volume: 61, Issue:4 Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Cloning, Molecular; Electrophysiology; Myocardium; Oocytes; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Quinidine; Sotalol; Xenopus laevis	1993
Inhibition of ATP-sensitive potassium channels in cardiac myocytes by the novel class III antiarrhythmic agent MS-551. Pharmacology & toxicology, 1995, Volume: 77, Issue:1 Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Female; Male; Myocardium; Patch-Clamp Techniques; Potassium Channels; Pyrimidinones; Rabbits; Regression Analysis	1995
Electrophysiological effects of MS-551 in humans: a class III antiarrhythmic agent. Pacing and clinical electrophysiology : PACE, 1995, Volume: 18, Issue:11 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrioventricular Node; Blood Pressure; Bundle of His; Electrocardiography; Electrophysiology; Female; Heart Atria; Heart Rate; Heart Ventricles; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Pyrimidinones; Refractory Period, Electrophysiological; Sinoatrial Node; Tachycardia	1995
Comparison of direct negative chronotropic and positive inotropic effects of sematilide to those of E-4031 and MS-551 and the reverse frequency-dependent prolongation of cardiac refractoriness of sematilide. Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Dogs; Female; Heart Rate; Male; Papillary Muscles; Piperidines; Procainamide; Pyridines; Pyrimidinones; Sinoatrial Node	1996
Interaction of class III antiarrhythmic drugs with muscarinic M2 and M3 receptors: radioligand binding and functional studies. Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 353, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; N-Methylscopolamine; Pyrimidinones; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Sotalol	1995
Differential effects of MS-551 and E-4031 on action potentials and the delayed rectifier K+ current in rabbit ventricular myocytes. Cardiovascular research, 1996, Volume: 31, Issue:6 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Female; Male; Myocardium; Patch-Clamp Techniques; Piperidines; Pyridines; Pyrimidinones; Rabbits; Sodium-Potassium-Exchanging ATPase	1996
Effects of class III antiarrhythmic drugs on the Na(+)-activated K+ channels in guinea-pig ventricular cells. British journal of pharmacology, 1996, Volume: 119, Issue:1 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Ouabain; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Sodium	1996
IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. British journal of pharmacology, 1996, Volume: 119, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Vessels; Heart Rate; Ischemia; Male; Phenethylamines; Procainamide; Pyrimidinones; Rats; Rats, Sprague-Dawley; Reperfusion; Sulfonamides	1996
Can a class III antiarrhythmic drug improve electrical defibrillation efficacy during ventricular fibrillation? Journal of the American College of Cardiology, 1997, Mar-01, Volume: 29, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Heart; Pyrimidinones; Treatment Outcome; Ventricular Fibrillation	1997
Different effects of class Ic and III antiarrhythmic drugs on vagotonic atrial fibrillation in the canine heart. Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Dogs; Electric Stimulation; Female; Lidocaine; Male; Pyrimidinones; Vagus Nerve	1998
[The effect of MS-551 on two VT/Vf patients in CABG: a case report]. Kyobu geka. The Japanese journal of thoracic surgery, 1998, Volume: 51, Issue:2 Topics: Aged; Angina, Unstable; Anti-Arrhythmia Agents; Cardiopulmonary Bypass; Coronary Artery Bypass; Humans; Intraoperative Care; Male; Middle Aged; Myocardial Infarction; Pyrimidinones	1998
Electrophysiological effects of MS-551, a new class III agent: comparison with dl-sotalol in dogs. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2 Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Dogs; Electrocardiography; Epinephrine; Heart; Male; Pyrimidinones; Refractory Period, Electrophysiological; Sotalol	1998
Effects of class I and III antiarrhythmic drugs on ventricular tachycardia-interrupting critical paced cycle length with rapid pacing. Japanese circulation journal, 1998, Volume: 62, Issue:4 Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Child; Electrophysiology; Female; Heart Conduction System; Humans; Male; Middle Aged; Piperidines; Pyridines; Pyrimidinones; Tachycardia, Ventricular	1998
Electrophysiologic effects of intravenous MS-551, a novel class III antiarrhythmic agent, on human atrium and ventricle. Japanese heart journal, 1998, Volume: 39, Issue:3 Topics: Adolescent; Adult; Analysis of Variance; Anti-Arrhythmia Agents; Drug Evaluation; Electrocardiography; Electrophysiology; Female; Heart; Heart Atria; Heart Ventricles; Humans; Infusions, Intravenous; Male; Middle Aged; Pyrimidinones; Tachycardia, Ventricular	1998
MS-551 and KCB-328, two class III drugs aggravated adrenaline-induced arrhythmias. British journal of pharmacology, 1998, Volume: 124, Issue:8 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Dogs; Electrocardiography; Epinephrine; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Phenethylamines; Propranolol; Pyrimidinones; Sulfonamides	1998
Comparison of electrophysiologic effects of intravenous E-4031 and MS-551, novel class III antiarrhythmic agents, in patients with ventricular tachyarrhythmias. Japanese heart journal, 1998, Volume: 39, Issue:4 Topics: Adult; Aged; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Heart Ventricles; Humans; Infusions, Intravenous; Male; Middle Aged; Piperidines; Pyridines; Pyrimidinones; Tachycardia, Ventricular; Treatment Outcome	1998
Concentration-dependent block of sodium current in guinea pig ventricular myocytes by a class III antiarrhythmic agent, MS-551. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; Pyrimidinones; Sodium Channel Blockers	1998
Effect of a class III antiarrhythmic drug on the configuration of dose response curve for defibrillation. Pacing and clinical electrophysiology : PACE, 1999, Volume: 22, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electric Countershock; Electrocardiography; Electrophysiology; Pyrimidinones; Ventricular Fibrillation	1999
Electrophysiologic and blood-flow responses in the endocardium and epicardium to disopyramide and MS-551 during myocardial ischemia in the dog. Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Circulation; Disopyramide; Dogs; Endocardium; Myocardial Ischemia; Pericardium; Pyrimidinones; Refractory Period, Electrophysiological	1999
Frequency-dependent electrophysiological effects of flecainide, nifekalant and d,l-sotalol on the human atrium. Japanese circulation journal, 2001, Volume: 65, Issue:1 Topics: Action Potentials; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Cohort Studies; Drug Evaluation; Electrophysiologic Techniques, Cardiac; Flecainide; Heart Atria; Humans; Middle Aged; Pyrimidinones; Sotalol	2001
Initial experience with nifekalant hydrochloride (MS-551), a novel class III antiarrhythmic agent, in patients with acute extensive infarction and severe ventricular dysfunction. Japanese circulation journal, 2001, Volume: 65, Issue:1 Topics: Aged; Anti-Arrhythmia Agents; Electrocardiography; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Potassium Channel Blockers; Pyrimidinones; Tachycardia; Ventricular Dysfunction	2001
Reverse use-dependent QT prolongation during infusion of nifekalant in a case of recurrent ventricular tachycardia with old myocardial infarction. Journal of electrocardiology, 2001, Volume: 34, Issue:1 Topics: Anti-Arrhythmia Agents; Electrocardiography; Heart Ventricles; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Pyrimidinones; Tachycardia, Ventricular	2001
Efficacy of nifekalant hydrochloride on the treatment of life-threatening ventricular tachyarrhythmias during reperfusion for acute myocardial infarction. Cardiovascular drugs and therapy, 2001, Volume: 15, Issue:4 Topics: Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Coronary Angiography; Electric Countershock; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Pyrimidinones; Stents; Ventricular Fibrillation	2001
Antiarrhythmic effect of nifekalant on atrial tachyarrhythmia in four patients with severe heart failure. Journal of cardiology, 2002, Volume: 39, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Female; Heart Failure; Humans; Infusions, Intravenous; Male; Middle Aged; Pyrimidinones; Tachycardia	2002
Inhibitory effect of the class III antiarrhythmic drug nifekalant on HERG channels: mode of action. European journal of pharmacology, 2002, Dec-13, Volume: 457, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; In Vitro Techniques; Kinetics; Oocytes; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyrimidinones; Xenopus laevis	2002
[Efficacy of Nifekalant hydrochloride for life-threatening ventricular tachyarrhythmias in patients with resistance to lidocaine: a study of patients with out-of-hospital cardiac arrest]. Journal of cardiology, 2003, Volume: 41, Issue:3 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Drug Resistance; Emergency Medical Services; Epinephrine; Female; Heart Arrest; Humans; Lidocaine; Male; Middle Aged; Prospective Studies; Pyrimidinones; Tachycardia, Ventricular; Ventricular Fibrillation	2003
Pretreatments with a novel pure potassium channel blocker, Nifekalant, were effective in the electrical atrial defibrillation: a report of two cases. Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:6 Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Defibrillators, Implantable; Electric Countershock; Female; Humans; Male; Potassium Channel Blockers; Pyrimidinones	2002
Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach. Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:8 Topics: Aged; Anti-Arrhythmia Agents; Coronary Artery Bypass; Drug Resistance; Electric Countershock; Electrocardiography; Humans; Lidocaine; Male; Mexiletine; Potassium Channel Blockers; Pyrimidinones; Tachycardia, Ventricular	2003
Intravenous administration of nifekalant hydrochloride for the prevention of ischemia-induced ventricular tachyarrhythmia in patients with renal failure undergoing hemodialysis. Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:10 Topics: Aged; Anti-Arrhythmia Agents; Diabetic Nephropathies; Drug Monitoring; Electrocardiography; Humans; Injections, Intravenous; Male; Myocardial Ischemia; Pyrimidinones; Renal Dialysis; Renal Insufficiency; Tachycardia, Ventricular	2003
Effects of intravenous nifekalant, a class III antiarrhythmic drug, on atrial vulnerability parameters in patients with paroxysmal atrial fibrillation. Pacing and clinical electrophysiology : PACE, 2004, Volume: 27, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Appendage; Atrial Fibrillation; Atrial Function; Bundle of His; Coronary Vessels; Electrocardiography; Electrophysiology; Female; Heart Ventricles; Humans; Infusions, Intravenous; Linear Models; Male; Matched-Pair Analysis; Middle Aged; Pyrimidinones; Refractory Period, Electrophysiological; Time Factors	2004
Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models. Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Dogs; Electrocardiography; Female; Heart Block; Heart Rate; Male; Models, Animal; Pyrimidinones; Vascular Resistance; Ventricular Pressure	2004
Development of a halothane-adrenaline arrhythmia model using in vivo Guinea pigs. Journal of pharmacological sciences, 2004, Volume: 95, Issue:2 Topics: Adrenergic alpha-Agonists; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Diltiazem; Electrocardiography; Epinephrine; Guinea Pigs; Halothane; Long QT Syndrome; Male; Pyrimidinones; Vagotomy	2004
Experience with nifekalant hydrochloride in a patient with ischemic cardiomyopathy and severe ventricular dysfunction after dor operation. Japanese heart journal, 2004, Volume: 45, Issue:4 Topics: Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Cardiomyopathies; Electric Countershock; Humans; Male; Middle Aged; Myocardial Ischemia; Pyrimidinones; Tachycardia, Ventricular; Treatment Outcome; Ventricular Dysfunction, Left	2004
Crystals in the heart. Heart (British Cardiac Society), 2004, Volume: 90, Issue:10 Topics: Adult; Cardiomyopathy, Dilated; Crystallization; Echocardiography, Transesophageal; Female; Heart Diseases; Humans; Infusions, Intravenous; Potassium Channel Blockers; Pyrimidinones; Thrombosis	2004
Defibrillation effects of intravenous nifekalant in patients with out-of-hospital ventricular fibrillation. Pacing and clinical electrophysiology : PACE, 2005, Volume: 28 Suppl 1 Topics: Adult; Aged; Anti-Arrhythmia Agents; Electric Countershock; Emergency Treatment; Female; Humans; Injections, Intravenous; Male; Middle Aged; Pyrimidinones; Ventricular Fibrillation	2005
[Nifekalant hydrochloride as an effective treatment for postoperative ischemic heart disease]. Kyobu geka. The Japanese journal of thoracic surgery, 2005, Volume: 58, Issue:4 Topics: Aged; Anti-Arrhythmia Agents; Coronary Artery Bypass; Female; Humans; Injections, Intravenous; Male; Myocardial Ischemia; Postoperative Complications; Pyrimidinones; Tachycardia, Ventricular	2005
Combined effects of nifekalant and lidocaine on the spiral-type re-entry in a perfused 2-dimensional layer of rabbit ventricular myocardium. Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Female; Heart; Heart Conduction System; Image Interpretation, Computer-Assisted; Lidocaine; Male; Pyrimidinones; Rabbits; Radiography	2005
Effect of IKr blocker nifekalant on atrial action potential duration after successful internal cardioversion of chronic atrial fibrillation. Pacing and clinical electrophysiology : PACE, 2005, Volume: 28, Issue:5 Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Electric Countershock; Female; Heart Atria; Heart Rate; Humans; Male; Middle Aged; Pyrimidinones; Refractory Period, Electrophysiological	2005
Effect of nifekalant, a class III anti-arrhythmic agent, on Ca2+ waves in rat intact trabeculae. Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Calcium; Dose-Response Relationship, Drug; Pyrimidinones; Rats; Rats, Sprague-Dawley; Ventricular Function	2005
Efficacy of nifekalant hydrochloride in the treatment of fatal ventricular arrhythmia in patients with ischemic heart disease. International heart journal, 2005, Volume: 46, Issue:4 Topics: Aged; Anti-Arrhythmia Agents; Drug Administration Schedule; Electrocardiography; Female; Humans; Male; Multivariate Analysis; Myocardial Ischemia; Prognosis; Pyrimidinones; Survival Rate; Tachycardia, Ventricular; Ventricular Fibrillation	2005
Emergency treatment with nifekalant, a novel class III anti-arrhythmic agent, for life-threatening refractory ventricular tachyarrhythmias: post-marketing special investigation. Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:10 Topics: Aged; Anti-Arrhythmia Agents; Emergency Medical Services; Female; Humans; Male; Marketing; Middle Aged; Pyrimidinones; Torsades de Pointes; Ventricular Fibrillation	2005
[Treatment for perioperative arrhythmias with nifekalant hydrochloride]. Kyobu geka. The Japanese journal of thoracic surgery, 2006, Volume: 59, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Flutter; Cardiac Surgical Procedures; Female; Humans; Male; Middle Aged; Postoperative Complications; Pyrimidinones; Tachycardia, Ventricular; Ventricular Fibrillation	2006
Comparison of nifekalant and lidocaine for the treatment of shock-refractory ventricular fibrillation. Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:4 Topics: Aged; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Epinephrine; Female; Heart Arrest; Humans; Lidocaine; Male; Middle Aged; Multivariate Analysis; Pyrimidinones; Retrospective Studies; Survival Rate; Time Factors; Ventricular Fibrillation	2006
Reduced inotropic effect of nifekalant in failing hearts in rats. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium; Cardiotonic Agents; Disease Models, Animal; Heart Failure; Monocrotaline; Myocardial Contraction; Pyrimidinones; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum	2006
Effects of antiarrhythmic drugs on apoptotic pathways in H9c2 cardiac cells. Journal of pharmacological sciences, 2006, Volume: 101, Issue:4 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Apoptosis; Caspases; Cell Line; Clone Cells; Diploidy; DNA Fragmentation; Dose-Response Relationship, Drug; Lidocaine; Membrane Potentials; Mitochondrial Membranes; Propranolol; Pyrimidinones; Signal Transduction; Time Factors; Verapamil	2006
Mechanisms of destabilization and early termination of spiral wave reentry in the ventricle by a class III antiarrhythmic agent, nifekalant. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Female; Heart Conduction System; Heart Ventricles; Male; Pyrimidinones; Rabbits; Tachycardia, Ventricular; Treatment Outcome	2007
Nifekalant hydrochloride administration during cardiopulmonary resuscitation improves the transmural dispersion of myocardial repolarization: experimental study in a canine model of cardiopulmonary arrest. Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Disease Models, Animal; Dogs; Heart Arrest; Heart Conduction System; Humans; Pyrimidinones; Tachycardia, Ventricular; Ventricular Fibrillation	2006
Effect of nifekalant on acute electrical remodelling in rapid atrial pacing canine model. Chinese medical journal, 2006, Dec-20, Volume: 119, Issue:24 Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Female; Male; Pyrimidinones; Refractory Period, Electrophysiological	2006
Analysis of arrhythmogenic profile in a canine model of chronic atrioventricular block by comparing in vitro effects of the class III antiarrhythmic drug nifekalant on the ventricular action potential indices between normal heart and atrioventricular bloc Journal of pharmacological sciences, 2007, Volume: 103, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Heart Block; Heart Ventricles; Microelectrodes; Purkinje Fibers; Pyrimidinones	2007
[Nifekalant hydrochloride effective against perioperative ventricular tachycardia in patients with impaired left ventricular function]. Kyobu geka. The Japanese journal of thoracic surgery, 2007, Volume: 60, Issue:6 Topics: Adult; Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Electrocardiography; Female; Humans; Male; Perioperative Care; Pyrimidinones; Tachycardia, Ventricular; Ventricular Function, Left	2007
[Case of intractable ventricula fibrillation by a multicomponent dietary supplement containing ephedra and caffeine overdose]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2007, Volume: 20, Issue:3 Topics: Adult; Caffeine; Dietary Supplements; Drug Overdose; Drug Synergism; Electric Countershock; Ephedra; Female; Humans; Hypokalemia; Lidocaine; Magnesium; Pyrimidinones; Ventricular Fibrillation	2007
Effect of nifekalant for acute conversion of atrial flutter: the possible termination mechanism of typical atrial flutter. Pacing and clinical electrophysiology : PACE, 2007, Volume: 30, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Flutter; Electrocardiography; Female; Hemodynamics; Humans; Male; Middle Aged; Prospective Studies; Pyrimidinones; Torsades de Pointes	2007
[Successful administration of nifekalant hydrochloride for postoperative junctional ectopic tachycardia in congenital cardiac surgery]. Kyobu geka. The Japanese journal of thoracic surgery, 2007, Volume: 60, Issue:11 Topics: Anti-Arrhythmia Agents; Humans; Infant; Male; Postoperative Complications; Pyrimidinones; Tachycardia, Ectopic Junctional; Tetralogy of Fallot	2007
[Despite medication, overdrive pacing is required to stabilize the electrical storm associated with acute coronary syndrome: a case report]. Journal of cardiology, 2007, Volume: 50, Issue:4 Topics: Acute Coronary Syndrome; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Drug Resistance; Female; Humans; Myocardial Infarction; Pyrimidinones; Stents; Tachycardia, Ventricular; Treatment Outcome	2007
Human atrial natriuretic peptide suppresses torsades de pointes in rabbits. Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Natriuretic Factor; Calcium Channels, L-Type; Cyclic GMP; Disease Models, Animal; Electrocardiography; Humans; Hydralazine; Male; Methoxamine; Pyrimidinones; Rabbits; Sympathomimetics; Torsades de Pointes; Vasodilator Agents	2008
Nifekalant and disopyramide in a patient with short QT syndrome: evaluation of pharmacological effects and electrophysiological properties. Pacing and clinical electrophysiology : PACE, 2008, Volume: 31, Issue:9 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Body Surface Potential Mapping; Disopyramide; Humans; Male; Pyrimidinones; Syndrome; Tachycardia, Ventricular; Treatment Outcome; Young Adult	2008
Nifekalant versus lidocaine for in-hospital shock-resistant ventricular fibrillation or tachycardia. Resuscitation, 2010, Volume: 81, Issue:1 Topics: Aged; Anti-Arrhythmia Agents; Chi-Square Distribution; Female; Humans; Lidocaine; Male; Middle Aged; Prospective Studies; Pyrimidinones; Statistics, Nonparametric; Survival Rate; Tachycardia, Ventricular; Treatment Outcome; Ventricular Fibrillation	2010
Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs. Stem cell research, 2010, Volume: 4, Issue:3 Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Electrophysiological Phenomena; Embryonic Stem Cells; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Pyrimidinones	2010
Nifekalant hydrochloride terminated electrical storms after coronary surgery. The Annals of thoracic surgery, 2010, Volume: 89, Issue:5 Topics: Aged; Anti-Arrhythmia Agents; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Myocardial Infarction; Postoperative Complications; Pyrimidinones; Severity of Illness Index; Tachycardia, Ventricular; Treatment Outcome	2010
Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest. Resuscitation, 2010, Volume: 81, Issue:8 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Arrest; Heart Rate; Male; Pyrimidinones; Swine; Treatment Outcome; Ventricular Fibrillation; Ventricular Function	2010
Report from J-PULSE multicenter registry of patients with shock-resistant out-of-hospital cardiac arrest treated with nifekalant hydrochloride. Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:11 Topics: Aged; Anti-Arrhythmia Agents; Defibrillators; Electric Countershock; Electrocardiography; Feasibility Studies; Female; Humans; Japan; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Patient Admission; Pilot Projects; Prospective Studies; Pyrimidinones; Registries; Survival Analysis; Survival Rate; Time Factors; Torsades de Pointes; Treatment Failure; Ventricular Fibrillation	2010
[Clinical experience with intravenous administration of nifekalant hydrochloride for ventricular tachycardia in a hemodialysis patient after open heart surgery]. Kyobu geka. The Japanese journal of thoracic surgery, 2010, Volume: 63, Issue:11 Topics: Aged; Anti-Arrhythmia Agents; Aortic Valve; Heart Valve Prosthesis; Hemodialysis Solutions; Humans; Kidney Failure, Chronic; Male; Postoperative Complications; Pyrimidinones; Tachycardia, Ventricular	2010
Nifekalant hydrochloride for patients with cardiac arrest caused by shockable rhythm. Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:11 Topics: Anti-Arrhythmia Agents; Defibrillators; Electric Countershock; Humans; Out-of-Hospital Cardiac Arrest; Patient Admission; Pyrimidinones; Survival Rate; Tachycardia, Ventricular; Time Factors; Torsades de Pointes; Treatment Failure; Ventricular Fibrillation	2010
Deep anesthesia suppresses ventricular tachyarrhythmias in rabbit model of the acquired long QT syndrome. Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, General; Anesthetics, Combined; Animals; Anti-Arrhythmia Agents; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Ketamine; Long QT Syndrome; Male; Methoxamine; Pyrimidinones; Rabbits; Tachycardia, Ventricular; Time Factors; Xylazine	2011
Effect of the ATP-sensitive K⁺ channel opener nicorandil in a canine model of proarrhythmia. International heart journal, 2011, Volume: 52, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; KATP Channels; Long QT Syndrome; Nicorandil; Pyrimidinones; Torsades de Pointes; Ventricular Premature Complexes	2011
A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents. Biochemical and biophysical research communications, 2011, Nov-11, Volume: 415, Issue:1 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydantoins; Imidazolidines; Membrane Potentials; Piperazines; Pyrimidinones; Xenopus laevis	2011
Nifekalant enlarged the transmural activation-recovery interval difference as well as the peak-to-end interval on surface ECG in a patient with short-QT syndrome. Journal of cardiovascular electrophysiology, 2012, Volume: 23, Issue:8 Topics: Action Potentials; Adolescent; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiologic Techniques, Cardiac; Fatal Outcome; Female; Heart Conduction System; Heart Defects, Congenital; Heart Rate; Humans; Predictive Value of Tests; Pyrimidinones; Time Factors; Treatment Outcome	2012
Development of recombinant cell line co-expressing mutated Nav1.5, Kir2.1, and hERG for the safety assay of drug candidates. Journal of biomolecular screening, 2012, Volume: 17, Issue:6 Topics: Action Potentials; Biological Assay; Cell Line; Cisapride; Drug Evaluation, Preclinical; Ether-A-Go-Go Potassium Channels; HEK293 Cells; High-Throughput Screening Assays; Humans; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyridines; Pyrimidinones; Sodium Channels; Terfenadine; Transfection; Verapamil	2012
Pharmacologic atrial defibrillation by drug delivery into the temporarily occluded coronary sinus. A canine study. International heart journal, 2012, Volume: 53, Issue:2 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Balloon Occlusion; Cardiac Pacing, Artificial; Chronic Disease; Coronary Sinus; Dogs; Drug Delivery Systems; Injections, Intravenous; Lidocaine; Pyrimidinones; Treatment Outcome	2012
Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome. Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:10 Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Arrhythmia Agents; Clonidine; Dexmedetomidine; Disease Models, Animal; Heart Conduction System; Humans; Long QT Syndrome; Methoxamine; Pyrimidinones; Rabbits; Tachycardia	2012
An HPLC method for the determination of nifekalant hydrochloride in canine plasma and its application to a pharmacokinetic study. Journal of chromatographic science, 2013, Volume: 51, Issue:9 Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Female; Least-Squares Analysis; Liquid-Liquid Extraction; Male; Pyrimidinones; Reproducibility of Results; Sensitivity and Specificity	2013
Electrophysiologic mechanism of typical atrial flutter termination by nifekalant: effect of a pure IKr -selective blocking agent. Pacing and clinical electrophysiology : PACE, 2013, Volume: 36, Issue:9 Topics: Aged; Anti-Arrhythmia Agents; Atrial Flutter; Body Surface Potential Mapping; Female; Heart Conduction System; Humans; Male; Models, Cardiovascular; Potassium Channel Blockers; Pyrimidinones; Treatment Outcome	2013
The application of an LC-MS/MS method in a pharmacokinetic study for the determination of the concentration of nifekalant in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Nov-01, Volume: 938 Topics: Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Limit of Detection; Linear Models; Male; Pyrimidinones; Reproducibility of Results; Tandem Mass Spectrometry	2013
Rate-dependent electrophysiologic effects of the class III antiarrhythmic drugs nifekalant, amiodarone, and ibutilide on the atrium in patients with persistent atrial fibrillation. International heart journal, 2013, Volume: 54, Issue:5 Topics: Action Potentials; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Female; Heart Atria; Heart Conduction System; Humans; Male; Middle Aged; Pyrimidinones; Sulfonamides	2013
Comparison of nifekalant and amiodarone for resuscitation of out-of-hospital cardiopulmonary arrest resulting from shock-resistant ventricular fibrillation. Journal of anesthesia, 2014, Volume: 28, Issue:4 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Dose-Response Relationship, Drug; Electric Countershock; Female; Humans; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Prospective Studies; Pyrimidinones; Retrospective Studies; Ventricular Fibrillation	2014
Effects of pH on nifekalant-induced electrophysiological change assessed in the Langendorff heart model of guinea pigs. Journal of pharmacological sciences, 2014, Volume: 124, Issue:2 Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Electrocardiography; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Male; Perfusion; Pyrimidinones; Time Factors; Torsades de Pointes	2014
Nifekalant Versus Amiodarone in the Treatment of Cardiac Arrest: an Experimental Study in a Swine Model of Prolonged Ventricular Fibrillation. Cardiovascular drugs and therapy, 2015, Volume: 29, Issue:5 Topics: Amiodarone; Animals; Blood Pressure; Cardiopulmonary Resuscitation; Disease Models, Animal; Electric Countershock; Epinephrine; Female; Heart Arrest; Heart Rate; Pyrimidinones; Survival Analysis; Swine; Ventricular Fibrillation	2015
Nifekalant Hydrochloride and Amiodarone Hydrochloride Result in Similar Improvements for 24-Hour Survival in Cardiopulmonary Arrest Patients: The SOS-KANTO 2012 Study. Journal of cardiovascular pharmacology, 2015, Volume: 66, Issue:6 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Humans; Japan; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Pyrimidinones; Survival Rate; Treatment Outcome	2015
Amiodarone or nifekalant upon hospital arrival for refractory ventricular fibrillation after out-of-hospital cardiac arrest. Resuscitation, 2016, Volume: 109 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Emergency Medical Services; Female; Hospital Mortality; Hospitalization; Humans; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Pyrimidinones; Retrospective Studies; Ventricular Fibrillation; Young Adult	2016
Crystallization granuloma by nifekalant hydrochloride infusion. Geriatrics & gerontology international, 2018, Volume: 18, Issue:7 Topics: Aged; Atrial Fibrillation; Biopsy, Needle; Crystallization; Follow-Up Studies; Foot; Granuloma; Hand; Humans; Immunohistochemistry; Infusions, Intravenous; Male; Pyrimidinones; Rare Diseases; Risk Assessment	2018
Negative lusitropic property of nifekalant identified using ventricular pressure-volume loop analyses in anesthetized monkeys. Experimental animals, 2019, Feb-26, Volume: 68, Issue:1 Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Volume; Depression, Chemical; Diastole; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Hemodynamics; Infusions, Intravenous; Macaca fascicularis; Male; Myocardial Contraction; Pyrimidinones; Ventricular Function, Left; Ventricular Pressure	2019
Facilitation of The Journal of general physiology, 2019, 02-04, Volume: 151, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cells, Cultured; ERG1 Potassium Channel; HEK293 Cells; Humans; Myocytes, Cardiac; Phenethylamines; Potassium Channel Blockers; Pyrimidinones; Rabbits; Sulfonamides; Xenopus	2019
Efficacy of Nifekalant in Patients With Wolff-Parkinson-White Syndrome and Atrial Fibrillation: Electrophysiological and Clinical Findings. Journal of the American Heart Association, 2019, 07-02, Volume: 8, Issue:13 Topics: Accessory Atrioventricular Bundle; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Humans; Male; Middle Aged; Pyrimidinones; Tachycardia, Supraventricular; Ventricular Dysfunction, Left; Wolff-Parkinson-White Syndrome	2019
"Nonsignificant" early repolarization pattern on postresuscitation ECG as a harbinger of impending electrical storm. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2020, Volume: 25, Issue:3 Topics: Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Defibrillators, Implantable; Electric Countershock; Electrocardiography; Heart Arrest; Humans; Isosorbide Dinitrate; Magnesium; Male; Middle Aged; Potassium Chloride; Pyrimidinones; Vasodilator Agents; Ventricular Fibrillation	2020
Intraprocedural Conversion Efficacy of Intravenous Nifekalant Administration for Persistent Atrial Fibrillation after Pulmonary Vein Isolation. International heart journal, 2020, Nov-28, Volume: 61, Issue:6 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cryosurgery; Electric Countershock; Female; Heart Atria; Humans; Infusions, Intravenous; Intraoperative Care; Intraoperative Complications; Male; Middle Aged; Organ Size; Peripheral Nerve Injuries; Phrenic Nerve; Progression-Free Survival; Prospective Studies; Pulmonary Veins; Pyrimidinones; Recurrence; Tachycardia, Ventricular; Treatment Outcome	2020
Long-term nifekalant use in a patient with dilated cardiomyopathy and recurrent ventricular tachycardia. The Journal of international medical research, 2022, Volume: 50, Issue:10 Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Humans; Male; Pyrimidinones; Tachycardia, Ventricular	2022