Page last updated: 2024-09-03

nifekalant hydrochloride and amiodarone

nifekalant hydrochloride has been researched along with amiodarone in 22 studies

Compound Research Comparison

Studies
(nifekalant hydrochloride)
Trials
(nifekalant hydrochloride)
Recent Studies (post-2010)
(nifekalant hydrochloride)
Studies
(amiodarone)
Trials
(amiodarone)
Recent Studies (post-2010) (amiodarone)
13816388,1567431,889

Protein Interaction Comparison

ProteinTaxonomynifekalant hydrochloride (IC50)amiodarone (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.27
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.085
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.404
Bile salt export pumpHomo sapiens (human)10
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)9.148
Tyrosine-protein kinase FynHomo sapiens (human)0.817
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.271
Muscarinic acetylcholine receptor M2Homo sapiens (human)5.08
Muscarinic acetylcholine receptor M4Homo sapiens (human)3.63
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.499
Alpha-2A adrenergic receptorHomo sapiens (human)0.312
Thyroid hormone receptor alphaHomo sapiens (human)0.65
Thyroid hormone receptor betaHomo sapiens (human)0.6
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.613
Lethal factorBacillus anthracis3.5
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.201
D(1A) dopamine receptorHomo sapiens (human)9.142
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.271
5-hydroxytryptamine receptor 2AHomo sapiens (human)3.59
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.404
Sodium-dependent serotonin transporterHomo sapiens (human)2.305
Melanocortin receptor 5Homo sapiens (human)9.497
D(3) dopamine receptorHomo sapiens (human)1.208
Sodium channel protein type 1 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 4 subunit alphaHomo sapiens (human)4.8
Squalene synthaseHomo sapiens (human)8
Delta-type opioid receptorHomo sapiens (human)8.014
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.923
Sodium channel protein type 7 subunit alphaHomo sapiens (human)4.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.085
Sodium-dependent dopamine transporter Homo sapiens (human)2.505
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)6.206
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.085
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.085
Sodium channel protein type 5 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 9 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 2 subunit alphaHomo sapiens (human)4.8
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.097
Sodium channel protein type 3 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 11 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 8 subunit alphaHomo sapiens (human)4.8
Sodium channel protein type 10 subunit alphaHomo sapiens (human)4.8

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (9.09)18.2507
2000's8 (36.36)29.6817
2010's12 (54.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Masuda, Y; Mori, K; Nakaya, H; Saito, T1
Aizawa, Y; Naitoh, N; Takahashi, K; Washizuka, T1
Ohnishi, S1
Ito, H; Maruyama, T1
Honjo, H; Ishiguro, Y; Kamiya, K; Kodama, I; Nakagawa, H; Okuno, Y; Sakuma, I; Yamazaki, M1
Fujiki, A1
Sugi, K1
Arakaki, T; Isomoto, S; Kawakami, A; Ono, K; Yamashita, S; Yano, K1
Maeda, K; Nakagawa, E; Takagi, M; Tatsumi, H; Yoshiyama, M1
Abe, A; Ikeda, T; Ishiguro, H; Mera, H; Miwa, Y; Miyakoshi, M; Shimizu, H; Tsukada, T; Yoshino, H; Yusu, S1
Akieda, K; Amino, M; Fujibayashi, D; Fukushima, T; Hashida, T; Higami, S; Inokuchi, S; Kodama, I; Morita, S; Opthof, T; Otsuka, H; Shima, M; Tamura, K; Tanabe, T; Uemura, S; Yoshioka, K1
Cong, LH; Ji, XF; Li, CS; Wang, S; Yang, L1
Furutani, K; Inanobe, A; Iwata, M; Kurachi, Y; Ohno, Y; Yamakawa, Y1
Hirayama, A; Kofune, M; Kogawa, R; Mano, H; Nakai, T; Ohkubo, K; Okumura, Y; Sasaki, N; Sonoda, K; Watanabe, I1
Aibara, K; Goto, K; Harayama, N; Isa, Y; Kamochi, M; Nagata, K; Nihei, S; Sata, T1
Iacovidou, N; Karlis, G; Lelovas, P; Mentzelopoulos, S; Niforopoulou, P; Papalois, A; Siafaka, I; Xanthos, T1
Amino, M; Funakoshi, H; Hayakawa, K; Ikari, Y; Inokuchi, S; Matsuzaki, M; Morimura, N; Nagao, K; Nakagawa, Y; Sakurai, A; Tahara, Y; Yaguchi, A; Yonemoto, N; Yoshioka, K1
Aibara, K; Harayama, N; Kamochi, M; Nagata, K; Nihei, S; Sata, T1
Fukuda, R; Fushimi, K; Ishinokami, S; Kitahashi, A; Matsui, H; Oyanagi, M; Tagami, T; Unemoto, K; Yasunaga, H1
Koyfman, A; Long, B1
Tagami, T; Yasunaga, H; Yokota, H1
Chuma, M; Imai, T; Ishizawa, K; Izawa-Ishizawa, Y; Koga, T; Kondo, Y; Koyama, T; Kurata, Y; Nakura, H; Niimura, T; Sato, S; Sendo, T; Takechi, K; Tanaka, S; Zamami, Y1

Reviews

9 review(s) available for nifekalant hydrochloride and amiodarone

ArticleYear
[Management of lethal ventricular arrhythmias after cardiac surgery].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:7

    Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Catheter Ablation; Humans; Intra-Aortic Balloon Pumping; Postoperative Complications; Pyrimidinones; Recurrence; Tachycardia, Ventricular; Ventricular Fibrillation

2002
[Recent findings on the dromotropic actions of the class III antiarrhythmic agents].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 120, Issue:5

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Neural Conduction; Pyrimidinones; Sotalol

2002
Optical imaging of spiral waves: pharmacological modification of spiral-type excitations in a 2-dimensional layer of ventricular myocardium.
    Journal of electrocardiology, 2005, Volume: 38, Issue:4 Suppl

    Topics: Amiodarone; Animals; Anisotropy; Anti-Arrhythmia Agents; Heart Conduction System; Humans; Myocardium; Pre-Excitation Syndromes; Pyrimidinones; Signal Processing, Computer-Assisted; Sodium Channel Blockers; Tachycardia, Ventricular

2005
[Present status in and prospects for anti-arrhythmic drug therapy: How to use type III anti-arrhythmic agents].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2006, Feb-10, Volume: 95, Issue:2

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bepridil; Drug Therapy, Combination; Humans; Pyrimidinones; Sotalol

2006
[Strategy for cardiac arrhythmias in acute coronary syndrome].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64, Issue:4

    Topics: Amiodarone; Angina, Unstable; Anti-Asthmatic Agents; Aprindine; Atrial Fibrillation; Bepridil; Electric Countershock; Humans; Myocardial Infarction; Potassium Channel Blockers; Pyrimidinones; Recurrence; Syndrome; Tachycardia, Ventricular; Ventricular Fibrillation

2006
[Drug Therapy for Shock-Resistant Ventricular Fibrillation: Comparison of Nifekalant and Amiodarone].
    Journal of UOEH, 2016, Mar-01, Volume: 38, Issue:1

    Topics: Amiodarone; Anti-Asthmatic Agents; Defibrillators; Humans; Injections, Intravenous; Potassium Channel Blockers; Pyrimidinones; Ventricular Fibrillation

2016
Best Clinical Practice: Emergency Medicine Management of Stable Monomorphic Ventricular Tachycardia.
    The Journal of emergency medicine, 2017, Volume: 52, Issue:4

    Topics: Amiodarone; Anti-Arrhythmia Agents; Electric Countershock; Electrocardiography; Emergency Service, Hospital; Evidence-Based Medicine; Humans; Lidocaine; Procainamide; Pyrimidinones; Review Literature as Topic; Sotalol; Tachycardia, Ventricular

2017
Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation.
    Critical care (London, England), 2017, Mar-21, Volume: 21, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Emergency Medical Services; Humans; Intensive Care Units; Lidocaine; Out-of-Hospital Cardiac Arrest; Placebos; Pyrimidinones; Ventricular Fibrillation

2017
Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia.
    Scientific reports, 2017, 10-04, Volume: 7, Issue:1

    Topics: Amiodarone; Humans; Publication Bias; Pulse; Pyrimidinones; Randomized Controlled Trials as Topic; Survival Analysis; Tachycardia, Ventricular; Treatment Outcome; Ventricular Fibrillation

2017

Trials

3 trial(s) available for nifekalant hydrochloride and amiodarone

ArticleYear
The effects of nifekalant hydrochloride on the QT dispersion after direct-current defibrillation.
    Osaka city medical journal, 2008, Volume: 54, Issue:1

    Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Electrocardiography; Female; Humans; Male; Middle Aged; Pyrimidinones; Sotalol; Tachycardia, Ventricular; Ventricular Fibrillation; Ventricular Function, Left

2008
Effects of intravenous nifekalant as a lifesaving drug for severe ventricular tachyarrhythmias complicating acute coronary syndrome.
    Circulation journal : official journal of the Japanese Circulation Society, 2009, Volume: 73, Issue:11

    Topics: Acute Coronary Syndrome; Aged; Amiodarone; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Emergency Medical Services; Female; Heart Rate; Humans; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Male; Middle Aged; Pyrimidinones; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Fibrillation

2009
Comparative study of nifekalant versus amiodarone for shock-resistant ventricular fibrillation in out-of-hospital cardiopulmonary arrest patients.
    Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:4

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electric Countershock; Emergency Service, Hospital; Female; Heart Arrest; Heart Diseases; Humans; Male; Middle Aged; Prognosis; Pyrimidinones; Survival Analysis; Treatment Outcome; Ventricular Fibrillation

2010

Other Studies

10 other study(ies) available for nifekalant hydrochloride and amiodarone

ArticleYear
Effects of class III antiarrhythmic drugs on the Na(+)-activated K+ channels in guinea-pig ventricular cells.
    British journal of pharmacology, 1996, Volume: 119, Issue:1

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Ouabain; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Sodium

1996
Effects of class I and III antiarrhythmic drugs on ventricular tachycardia-interrupting critical paced cycle length with rapid pacing.
    Japanese circulation journal, 1998, Volume: 62, Issue:4

    Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Child; Electrophysiology; Female; Heart Conduction System; Humans; Male; Middle Aged; Piperidines; Pyridines; Pyrimidinones; Tachycardia, Ventricular

1998
Effects of antiarrhythmic drugs on apoptotic pathways in H9c2 cardiac cells.
    Journal of pharmacological sciences, 2006, Volume: 101, Issue:4

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Apoptosis; Caspases; Cell Line; Clone Cells; Diploidy; DNA Fragmentation; Dose-Response Relationship, Drug; Lidocaine; Membrane Potentials; Mitochondrial Membranes; Propranolol; Pyrimidinones; Signal Transduction; Time Factors; Verapamil

2006
Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest.
    Resuscitation, 2010, Volume: 81, Issue:8

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Arrest; Heart Rate; Male; Pyrimidinones; Swine; Treatment Outcome; Ventricular Fibrillation; Ventricular Function

2010
A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents.
    Biochemical and biophysical research communications, 2011, Nov-11, Volume: 415, Issue:1

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydantoins; Imidazolidines; Membrane Potentials; Piperazines; Pyrimidinones; Xenopus laevis

2011
Rate-dependent electrophysiologic effects of the class III antiarrhythmic drugs nifekalant, amiodarone, and ibutilide on the atrium in patients with persistent atrial fibrillation.
    International heart journal, 2013, Volume: 54, Issue:5

    Topics: Action Potentials; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Pacing, Artificial; Female; Heart Atria; Heart Conduction System; Humans; Male; Middle Aged; Pyrimidinones; Sulfonamides

2013
Comparison of nifekalant and amiodarone for resuscitation of out-of-hospital cardiopulmonary arrest resulting from shock-resistant ventricular fibrillation.
    Journal of anesthesia, 2014, Volume: 28, Issue:4

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Dose-Response Relationship, Drug; Electric Countershock; Female; Humans; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Prospective Studies; Pyrimidinones; Retrospective Studies; Ventricular Fibrillation

2014
Nifekalant Versus Amiodarone in the Treatment of Cardiac Arrest: an Experimental Study in a Swine Model of Prolonged Ventricular Fibrillation.
    Cardiovascular drugs and therapy, 2015, Volume: 29, Issue:5

    Topics: Amiodarone; Animals; Blood Pressure; Cardiopulmonary Resuscitation; Disease Models, Animal; Electric Countershock; Epinephrine; Female; Heart Arrest; Heart Rate; Pyrimidinones; Survival Analysis; Swine; Ventricular Fibrillation

2015
Nifekalant Hydrochloride and Amiodarone Hydrochloride Result in Similar Improvements for 24-Hour Survival in Cardiopulmonary Arrest Patients: The SOS-KANTO 2012 Study.
    Journal of cardiovascular pharmacology, 2015, Volume: 66, Issue:6

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Humans; Japan; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Pyrimidinones; Survival Rate; Treatment Outcome

2015
Amiodarone or nifekalant upon hospital arrival for refractory ventricular fibrillation after out-of-hospital cardiac arrest.
    Resuscitation, 2016, Volume: 109

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Emergency Medical Services; Female; Hospital Mortality; Hospitalization; Humans; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Pyrimidinones; Retrospective Studies; Ventricular Fibrillation; Young Adult

2016