Compounds > nifedipine

nifedipine and troleandomycin

nifedipine has been researched along with troleandomycin in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.76)18.7374
1990's5 (29.41)18.2507
2000's2 (11.76)29.6817
2010's8 (47.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pratim Roy, P; Roy, K1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Bonomo, F; Motta, P; Pagliarusco, S; Pellegatti, M; Pons, N1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Eaton, DL; Eddy, AC; Parkinson, A; Ramsdell, HS1
Guengerich, FP; Shimada, T1
Guengerich, FP1
Hiroki, S; Shimada, T; Urano, T; Yamazaki, H1
Ishizaki, T; Zhao, XJ1
Anzenbacher, P; Anzenbacherová, E; Gut, I; Hrubý, K; Kvĕtina, J; Soucek, P; Svoboda, Z1
Mason, SR; Read, MA; Reilly, PE1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T1
Choi, YH; Lee, MG1
Cruz, A; González-Curbelo, MÁ; León, J; Murcia, H1

Other Studies

17 other study(ies) available for nifedipine and troleandomycin

ArticleYear
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:7

    Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Adult; Cells, Cultured; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Models, Molecular; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperazines; Piperidines; Recombinant Proteins; Young Adult

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Bioactivation of aflatoxin B1 by human liver microsomes: role of cytochrome P450 IIIA enzymes.
    Toxicology and applied pharmacology, 1991, Volume: 108, Issue:3

    Topics: Aflatoxin B1; Aflatoxins; Benzoflavones; Biotransformation; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Troleandomycin

1991
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:2

    Topics: Aflatoxin B1; Aflatoxins; Antibodies; Benzoflavones; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Immunochemistry; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Sterigmatocystin; Troleandomycin

1989
Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.
    Molecular pharmacology, 1988, Volume: 33, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethinyl Estradiol; Humans; Immunologic Techniques; In Vitro Techniques; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Substrate Specificity; Troleandomycin

1988
Effects of erythromycin and roxithromycin on oxidation of testosterone and nifedipine catalyzed by CYP3A4 in human liver microsomes.
    The Journal of toxicological sciences, 1996, Volume: 21, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; Humans; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Roxithromycin; Testosterone; Troleandomycin

1996
Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:5

    Topics: Anti-Infective Agents; Antimalarials; Chromatography; Cytochrome P-450 Enzyme System; Doxycycline; Drug Interactions; Erythromycin; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Nifedipine; Omeprazole; Primaquine; Quinine; Tetracycline; Troleandomycin

1997
Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Swine; Swine, Miniature; Troleandomycin

1998
Human, rat and crocodile liver microsomal monooxygenase activities measured using diazepam and nifedipine: effects of CYP3A inhibitors and relationship to immunochemically detected CYP3A apoprotein.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1999, Volume: 122, Issue:2

    Topics: Alligators and Crocodiles; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Inhibitors; Female; Humans; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nifedipine; Oxidoreductases, N-Demethylating; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Substrate Specificity; Troleandomycin

1999
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
    The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin

2005
Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:5

    Topics: Administration, Oral; Animals; Baculoviridae; Blood Proteins; Cell Line; Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Humans; Injections, Intravenous; Intestinal Mucosa; Intestines; Isoenzymes; Kinetics; Male; Metformin; Microsomes, Liver; Nifedipine; Protein Binding; Quinine; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Troleandomycin

2012
Study on the inhibitory effect of furafylline and troleandomycin in the 7-methoxyresorufin-O-demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescen
    Journal of pharmaceutical and biomedical analysis, 2019, Feb-05, Volume: 164

    Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Microsomes, Liver; Nifedipine; Oxazines; Poultry; Theophylline; Troleandomycin

2019