nifedipine has been researched along with tolbutamide in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (11.63) | 18.7374 |
| 1990's | 11 (25.58) | 18.2507 |
| 2000's | 12 (27.91) | 29.6817 |
| 2010's | 15 (34.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Barnett, DW; Falke, LC; Gillis, KD; Misler, S; Pressel, DM; Scharp, DW | 1 |
| Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT | 1 |
| Hanson, RL; Isaacson, CM | 1 |
| Falke, LC; Gillis, KD; Misler, S; Pressel, DM | 1 |
| Wilson, C | 1 |
| Gandhi, TP; Gilbert, RN; Patel, RB; Raval, JD; Shah, GF | 1 |
| Baty, J; Dow, RJ; Isles, TE | 1 |
| Francini, F; Gagliardino, JJ | 1 |
| Bégin-Heick, N; Black, MA; Mealing, GA; Schwartz, JL; Whitfield, JF | 1 |
| Cahill, AL; Perlman, RL | 1 |
| Greer, MA; Greer, SE; Sato, N; Wang, X | 1 |
| Greer, MA; Inukai, T; Wang, X | 1 |
| Dong, MS; Gillam, EM; Guengerich, FP; Johnson, WW; Shimada, T; Yamazaki, H | 1 |
| Albuquerque-Silva, J; Herchuelz, A; Lebeau, C; Van Eylen, F | 1 |
| Yada, T; Yaekura, K; Yanagida, K | 1 |
| An, J; Becker, GW; Churgay, LM; Gold, G; Hale, JE; Osborne, JJ; Shi, Y; Stramm, LE; Zhao, G | 1 |
| Nakamura, J; Ogawa, Y; Suda, T; Suga, S; Takeo, T; Wakui, M | 1 |
| Forster, A; Hempenstall, J; Rades, T | 1 |
| Chang, Y; Li, GH; Lin, YF; Liu, Q; Mao, X; Misaki, N; Suga, S; Wakui, M; Wang, H; Wu, J | 1 |
| Bacová, Z; Geibel, J; Iglseder, E; Jakab, M; Lach, S; Langelüddecke, C; Paulmichl, M; Ritter, M; Schmidt, S; Strbák, V | 1 |
| Björklund, A; Catrina, SB; Grill, V; Hals, I; Ma, Z; Moruzzi, N; Oberholzer, J | 1 |
1 review(s) available for nifedipine and tolbutamide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for nifedipine and tolbutamide
| Article | Year |
|---|---|
The effect of nicardipine on glucose and drug-stimulated insulin secretion in normal volunteers.
Topics: Adult; Blood Glucose; C-Peptide; Calcium Channel Blockers; Glucose; Humans; Insulin; Insulin Secretion; Male; Nicardipine; Nifedipine; Tolbutamide | 1985 |
41 other study(ies) available for nifedipine and tolbutamide
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Stimulus-secretion coupling in beta-cells of transplantable human islets of Langerhans. Evidence for a critical role for Ca2+ entry.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Azides; Calcium; Cytosol; Electrophysiology; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Kinetics; Membrane Potentials; Nifedipine; Potassium Chloride; Sodium Azide; Time Factors; Tolbutamide | 1992 |
Characterization of metronidazole metabolism by human liver microsomes.
Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide | 1991 |
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Diterpenes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Nifedipine; Oxazoles; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide; Verapamil | 1985 |
'Perforated patch recording' allows long-term monitoring of metabolite-induced electrical activity and voltage-dependent Ca2+ currents in pancreatic islet B cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Azides; Calcium Channels; Diazoxide; Electric Conductivity; Glucose; Humans; Islets of Langerhans; Membrane Potentials; Nifedipine; Rats; Sodium Azide; Tolbutamide | 1989 |
Inhibition by sulphonylureas of vasorelaxation induced by K+ channel activators in vitro.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guanidines; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Sulfonylurea Compounds; Tolbutamide; Vasodilator Agents | 1989 |
Calcium antagonists and blood glucose in normal rabbits.
Topics: Animals; Blood Glucose; Calcium Channel Blockers; Glucose Tolerance Test; Insulin; Insulin Secretion; Male; Nifedipine; Rabbits; Tolbutamide; Verapamil | 1987 |
An in vitro model suitable for studying insulin secretion in amphibians.
Topics: Acetylcholine; Amphibians; Animals; Arginine; Bufo arenarum; Caproates; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Antagonists; Insulin Secretion; Keto Acids; Male; Nifedipine; Pancreatin; Potassium; Radioimmunoassay; Somatostatin; Swine; Tolbutamide | 1995 |
Insulin secretion and intracellular Ca2+ rises in monolayer cultures of neonatal rat beta-cells.
Topics: Age Factors; Animals; Calcium; Calcium Channels; Cells, Cultured; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nifedipine; Patch-Clamp Techniques; Potassium; Rats; Rats, Sprague-Dawley; Tolbutamide | 1994 |
Tetraethylammonium selectively stimulates secretion from noradrenergic bovine chromaffin cells.
Topics: 4-Aminopyridine; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Drug Interactions; Drug Synergism; Epinephrine; Glyburide; Nifedipine; Norepinephrine; Ouabain; Phorbol 12,13-Dibutyrate; Potassium Channel Blockers; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Tolbutamide | 1994 |
Evidence that tolbutamide induces prolactin secretion by a mechanism which does not involve blocking ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Nifedipine; Pituitary Gland, Anterior; Potassium Channels; Prolactin; Rats; Rats, Sprague-Dawley; Tolbutamide | 1994 |
Tetraethylammonium blockade of K+ channels in GH4C1 cells regulates prolactin secretion by inducing Ca2+ influx.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Membrane; Ion Transport; Nifedipine; Perfusion; Potassium; Potassium Channel Blockers; Potassium Channels; Prolactin; Rats; Tetraethylammonium; Tetraethylammonium Compounds; Thyrotropin-Releasing Hormone; Tolbutamide; Tumor Cells, Cultured | 1993 |
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Escherichia coli; Ethanolamines; Humans; Hydroxylation; Mixed Function Oxygenases; Mutation; NADP; Nifedipine; Oxidation-Reduction; Phospholipids; Recombinant Proteins; Testosterone; Theophylline; Tolbutamide; Warfarin | 1997 |
Contribution of Na/Ca exchange to Ca2+ outflow and entry in the rat pancreatic beta-cell: studies with antisense oligonucleotides.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Adhesion; Glucose; Hypoglycemic Agents; Ion Transport; Islets of Langerhans; Nifedipine; Oligonucleotides, Antisense; Potassium Chloride; Rats; Rats, Wistar; RNA, Messenger; Sodium; Sodium-Calcium Exchanger; Tolbutamide | 1998 |
PACAP and GLP-1 protect islet beta-cells against Ca2+ toxicity induced by high K+.
Topics: Animals; Arginine; Calcium; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Neuropeptides; Nifedipine; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium Chloride; Protein Precursors; Rats; Rats, Wistar; Tolbutamide | 1998 |
Threonine phosphorylations induced by RX-871024 and insulin secretagogues in betaTC6-F7 cells.
Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cytosol; Diazoxide; Exocytosis; Humans; Hypoglycemic Agents; Imidazoles; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isomerism; Membrane Potentials; Membrane Proteins; Myosin Heavy Chains; Nifedipine; Phosphorylation; Potassium Chloride; Protein Kinase C; Subcellular Fractions; Threonine; Tolbutamide | 1999 |
Protein kinase C-dependent and -independent inhibition of Ca(2+) influx by phorbol ester in rat pancreatic beta-cells.
Topics: Action Potentials; Animals; Biological Transport; Calcium; Calcium Channels, L-Type; Cells, Cultured; Drug Synergism; Enzyme Activation; Glucose; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Maleimides; Nifedipine; Pancreas; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Time Factors; Tolbutamide | 2001 |
Comparison of the Gordon-Taylor and Couchman-Karasz equations for prediction of the glass transition temperature of glass solutions of drug and polyvinylpyrrolidone prepared by melt extrusion.
Topics: Algorithms; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Differential Thermal Analysis; Humidity; Indomethacin; Nifedipine; Pharmaceutic Aids; Pharmaceutical Preparations; Povidone; Solubility; Temperature; Thermogravimetry; Tolbutamide | 2003 |
Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Diazoxide; Dose-Response Relationship, Drug; Female; Glucose; Humans; Insulin; Insulin-Secreting Cells; Ion Channel Gating; KATP Channels; Membrane Potentials; Nifedipine; Oocytes; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Propylamines; Rats; Tolbutamide; Xenopus laevis | 2007 |
Resveratrol inhibits electrical activity and insulin release from insulinoma cells by block of voltage-gated Ca+ channels and swelling-dependent Cl- currents.
Topics: Animals; Calcium Channels; Chloride Channels; Glucose; Insulin; Insulin Secretion; Insulinoma; Ion Channel Gating; Nifedipine; Patch-Clamp Techniques; Peptides; Rats; Resveratrol; Solutions; Stilbenes; Tolbutamide | 2008 |
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells.
Topics: AMP-Activated Protein Kinases; Animals; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Diabetes Mellitus, Experimental; Diazoxide; Electron Transport Chain Complex Proteins; Humans; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Insulin-Secreting Cells; Male; Mice; Nifedipine; Oxygen; Phosphorylation; Potassium; Proinsulin; Rats; Streptozocin; Tolbutamide | 2013 |