nifedipine and spironolactone

nifedipine has been researched along with spironolactone in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (7.14)	18.7374
1990's	4 (14.29)	18.2507
2000's	9 (32.14)	29.6817
2010's	13 (46.43)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Barecki, M; Casciano, CN; Clement, RP; Johnson, WW; Lew, K; Wang, E	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Carr, AA; Kaesemeyer, WH; Prisant, LM	1
Derkx, FH; Donckerwolcke, RA; Griffiven, AW; Schalekamp, MA; Vande Walle, JG; Veenhoven, RH; Wit, JM	1
Capron, MH; Henry, M; Pelletier, B; Wehrlen, M	1
Bolli, P; Brouwer, RM; Bühler, FR; Conen, D; Erné, P; Kiowski, W	1
Koren, G	1
Cherian, AM; Jesudason, SR; Kanagasabapathy, AS; Nair, A; Seshadri, MS	1
Al Saad, KO; Chan, NH	1
Goto, Y; Higuchi, S; Minemoto, M; Ohdo, S; Suematsu, F; Yukawa, E; Yukawa, M	1
Aisa, Y; Ikeda, Y; Kato, J; Mori, T; Nakamura, Y; Okamoto, S; Sakurai, M	1
Katayama, A; Makino, H; Matsumoto, Y; Nasu, Y; Otsuka, F; Tanabe, K; Tsukamoto, N; Yamanaka, R	1
Chayama, K; Fujii, Y; Fujimura, N; Hata, T; Hidaka, T; Higashi, Y; Idei, N; Iwamoto, Y; Kato, H; Kihara, Y; Liao, JK; Maruhashi, T; Mikami, S; Noma, K; Soga, J	1
Capuano, V; Ferron, L; Renaud, JF; Ruchon, Y; Sankhe, S	1
Alexander, T; Baylis, C; Cunningham, MW; Fekete, A; Masilamani, SM; Sasser, JM; Shaw, S; West, CA	1
Dorrance, AM; Jackson, WF; Pires, PW	1
Goto, M; Hasebe, N; Takahashi, F; Wada, Y	1
Ali, MA; Itai, S; Iwao, Y; Kataoka, N; Noguchi, S; Oka, T; Ranneh, AH	1

Reviews

1 review(s) available for nifedipine and spironolactone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for nifedipine and spironolactone

Article	Year
Spironolactone versus nifedipine in essential hypertension. The American journal of cardiology, 1990, Jun-19, Volume: 65, Issue:23 Topics: Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Multicenter Studies as Topic; Nifedipine; Randomized Controlled Trials as Topic; Spironolactone	1990
Antihypertensive treatment using calcium antagonists in combination with captopril rather than diuretics. Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 1 Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Captopril; Diuretics; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine; Proline; Renin; Renin-Angiotensin System; Spironolactone; Verapamil	1985
Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension. Clinical pharmacology and therapeutics, 2012, Volume: 91, Issue:2 Topics: Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Cell Movement; Endothelium, Vascular; Eplerenone; Female; Humans; Hypertension; Leukocytes; Losartan; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Nifedipine; Nitroglycerin; rho-Associated Kinases; Spironolactone; Stem Cells; Vascular Endothelial Growth Factor A; Vasodilation	2012

Other Studies

24 other study(ies) available for nifedipine and spironolactone

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chemical research in toxicology, 2001, Volume: 14, Issue:12 Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Mice; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Substrate Specificity	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Verapamil and nifedipine in combination for the treatment of hypertrophy heart disease. American journal of hypertension, 1991, Volume: 4, Issue:10 Pt 1 Topics: Adrenal Gland Diseases; Blood Pressure; Cardiovascular Diseases; Drug Therapy, Combination; Humans; Hyperaldosteronism; Hyperplasia; Hypertension; Male; Nifedipine; Spironolactone; Verapamil	1991
A neonate with idiopathic hyperaldosteronism. Pediatric nephrology (Berlin, Germany), 1991, Volume: 5, Issue:6 Topics: Aldosterone; Calcium; Gastrointestinal Diseases; Humans; Hyperaldosteronism; Hypokalemia; Infant, Newborn; Magnesium Hydroxide; Male; Nifedipine; Renin-Angiotensin System; Spironolactone	1991
Interaction between digoxin and commonly coadministered drugs in children. Pediatrics, 1985, Volume: 75, Issue:6 Topics: Amiodarone; Child, Preschool; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Nifedipine; Quinidine; Spironolactone; Verapamil	1985
Primary hyperaldosteronism--diagnostic approach and management. The Journal of the Association of Physicians of India, 1993, Volume: 41, Issue:5 Topics: Adult; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Hypokalemia; Male; Middle Aged; Nifedipine; Potassium; Spironolactone; Tomography, X-Ray Computed	1993
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. Pathology, 2001, Volume: 33, Issue:4 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Aldosterone; Humans; Hyperaldosteronism; Hypertension; Inclusion Bodies; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Nifedipine; Spironolactone; Tomography, X-Ray Computed; Vasodilator Agents; Zona Glomerulosa	2001
Pharmacoepidemiologic detection of calcium channel blocker-induced change on digoxin clearance using multiple trough screen analysis. Biopharmaceutics & drug disposition, 2002, Volume: 23, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Calcium Channel Blockers; Creatinine; Digoxin; Diltiazem; Drug Interactions; Female; Heart Failure; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Models, Statistical; Nifedipine; Pharmacoepidemiology; Regression Analysis; Reproducibility of Results; Spironolactone; Verapamil	2002
Hypotension due to the drug interaction of voriconazole with eplerenone and nifedipine. European journal of clinical pharmacology, 2009, Volume: 65, Issue:3 Topics: Antifungal Agents; Antihypertensive Agents; Drug Interactions; Drug Therapy, Combination; Eplerenone; Humans; Hypotension; Male; Middle Aged; Nifedipine; Pyrimidines; Spironolactone; Triazoles; Voriconazole	2009
Unexpected occurrence of adrenal Cushing's syndrome in a patient with systemic lupus erythematosus. Hypertension research : official journal of the Japanese Society of Hypertension, 2011, Volume: 34, Issue:5 Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adult; Angiomyolipoma; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Cushing Syndrome; Drug Therapy, Combination; Female; Humans; Hypertension; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Nifedipine; Prednisolone; Ribonucleosides; Spironolactone; Tetrazoles	2011
T-type Ca²⁺ signalling downregulates MEK1/2 phosphorylation and cross-talk with the RAAS transcriptional response in cardiac myocytes. Journal of molecular and cellular cardiology, 2012, Volume: 53, Issue:2 Topics: Animals; Calcium Signaling; Flunarizine; Fluoxetine; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mibefradil; Mifepristone; Mineralocorticoid Receptor Antagonists; Myocytes, Cardiac; Nifedipine; Phosphorylation; Rats; Rats, Wistar; Receptors, Glucocorticoid; Renin-Angiotensin System; Spironolactone	2012
Chronic vasodilation increases renal medullary PDE5A and α-ENaC through independent renin-angiotensin-aldosterone system pathways. American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Nov-15, Volume: 305, Issue:10 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cyclic Nucleotide Phosphodiesterases, Type 5; Diuretics; Enalapril; Epithelial Sodium Channels; Female; Kidney Medulla; Losartan; Nephrons; Nifedipine; Pregnancy; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sodium; Sodium Nitrite; Spironolactone; Vasodilation; Vasodilator Agents	2013
Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. American journal of physiology. Heart and circulatory physiology, 2015, Jul-01, Volume: 309, Issue:1 Topics: Animals; Antihypertensive Agents; Arterioles; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebrovascular Circulation; Cerebrum; Compliance; Eplerenone; Hydralazine; Hydrochlorothiazide; Hypertension; Middle Cerebral Artery; Mineralocorticoid Receptor Antagonists; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Mineralocorticoid; Reserpine; Spironolactone; Vascular Remodeling; Vascular Stiffness	2015
Successful Treatment with an Antihypertensive Drug Regimen Including Eplerenone in a Patient with Malignant Phase Hypertension with Renal Failure. Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:19 Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Creatinine; Drug Therapy, Combination; Eplerenone; Heart Failure; Humans; Hypertension, Malignant; Male; Nifedipine; Nitroglycerin; Obesity; Renal Insufficiency; Spironolactone; Tetrazoles; Treatment Outcome; Vasodilator Agents	2015
Enhancing the Solubility and Oral Bioavailability of Poorly Water-Soluble Drugs Using Monoolein Cubosomes. Chemical & pharmaceutical bulletin, 2017, Volume: 65, Issue:1 Topics: Administration, Oral; Biological Availability; Drug Carriers; Glycerides; Nifedipine; Particle Size; Solubility; Spironolactone; Surface Properties; Water	2017