nifedipine and quinidine

nifedipine has been researched along with quinidine in 80 studies

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199012 (15.00)18.7374
1990's22 (27.50)18.2507
2000's20 (25.00)29.6817
2010's23 (28.75)24.3611
2020's3 (3.75)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Keserü, GM1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M1
Nagashima, R; Nishikawa, T; Tobita, M1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
Jia, L; Sun, H1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M1
Ekins, S; Williams, AJ; Xu, JJ1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Budriesi, R; Carosati, E; Chiarini, A; Chiu, FC; Cosimelli, B; Frosini, M; Fusi, F; Ioan, P; Katneni, K; Matucci, R; Micucci, M; Saponara, S; Severi, E; Spinelli, D1
Jang, S; Jung, D; Lee, JW; Lee, S; Min, KH; Song, J1
Himori, N; Izumi, A1
Narimatsu, A; Taira, N1
Fardel, O; Guillouzo, A; Ketterer, B; Loyer, P; Ratanasavanh, D1
Hanano, M; Iga, T; Okudaira, K; Sawada, Y; Sugiyama, Y; Yamazaki, M1
Hunt, CM; Stave, GM; Westerkam, WR1
DeCoursey, TE; Jacobs, ER1
Bakker, EN; Breimer, DD; Ghabrial, H; Schellens, JH; van der Wart, HH; Wilkinson, GR1
Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT1
Chmel-Dunaj, GN; Jurevicius, J; Macianskiene, R; Muckus, K1
Bazill, GW; Dexter, TM1
Beaune, P; Cullin, C; Mansuy, D; Pompon, D; Renaud, JP1
Foster, BC; McGilveray, IJ; Wilson, DL1
Green, JA; Jarvis, RC; Kasmer, RJ; Munger, MA; Nair, R; Nara, AR; Urbancic, A1
Kuhlmann, J1
Blair, IA; Guengerich, FP; Müller-Enoch, D1
Koren, G1
Atanga, GK; Savage, AO1
Appleby, DH; Van Lith, RM1
Okada, Y; Tsuchiya, W; Yada, T1
Clementi, WA; Farringer, JA; Green, JA; Linn, WA; O'Rourke, RA1
Klejman, A; Liron, M; Livni, E; Rotmensch, HH; Sofferman, G; Weintraub, M1
Brendel, E; Henschel, L; Hippius, M; Hoffmann, A; Sigusch, H; Tepper, J1
Katina, IE; Luk'ianenko, VI; Nasledov, GA1
el-Tahtawy, AA; Jackson, AJ; Ludden, TM1
Buters, JT; Friedman, FK; Koley, AP; Markowitz, A; Robinson, RC1
Chen, XJ; Liu, TF1
Bowles, SK; Cardozo, L; Edwards, DJ; Reeves, RA1
Bailey, DG; Carruthers, SG; Edgar, B; Freeman, DJ; Kreeft, JH; Melendez, LJ1
Katina, IE; Lukyanenko, V; Nasledov, GA; Terentyev, DA1
Friedman, FK; Koley, AP; Markowitz, A; Robinson, RC1
Boucher, M; Chapuy, E; Chassaing, C; Lorente, P1
Beschke, K; Ebner, T; Ludwig, E; Schmid, J1
Liu, QY; Wang, XL1
Cook, A; Franks, CJ; Holden-Dye, L; Pemberton, D; Vinogradova, I; Walker, RJ1
Sakai, K; Sato, F; Shitan, N; Ueda, K; Yazaki, K1
Pan, YP; Wang, XL; Xu, XH1
Galetin, A; Hallifax, D; Houston, JB; Ito, K1
Abe, J; Hamada, Y; Harada, T; Hashimoto, K; Horii, I; Sawada, Y; Shiotani, M1
Foti, RS; Rock, DA; Wahlstrom, JL; Wienkers, LC1
Capria, E; Collins, S; Dodhia, VR; Fantuzzi, A; Gilardi, G; Huq, E; Mak, LH; Sadeghi, SJ; Somers, G1
Guengerich, FP; Shinkyo, R1
Matsumoto, A; Miki, T; Nakaya, H; Nishida, A; Seino, S; Takizawa, T1
Li, Y; Mathur, A; Maw, HH; Tweedie, DJ1
Ishigai, M; Kato, M; Mitsui, T; Miyake, T; Nagao, S; Nemoto, T; Ogawa, K; Yamada, H1
Bai, S; Cao, H; Chen, K; Dong, H; Ma, Y; Pei, J; Tian, L; Zhao, Y1
Baek, J; Choi, SO; Chung, HM; Kang, KR; Kim, CY; Kim, J; Lee, JM; Lee, SG; Oh, MS; Ryu, B1
Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H1

Reviews

1 review(s) available for nifedipine and quinidine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

4 trial(s) available for nifedipine and quinidine

ArticleYear
Pharmacokinetic interactions of nifedipine and quinidine.
    Die Pharmazie, 1995, Volume: 50, Issue:9

    Topics: Adult; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Drug Interactions; Half-Life; Humans; Male; Nifedipine; Quinidine

1995
Comparison of single and multiple dose pharmacokinetics using clinical bioequivalence data and Monte Carlo simulations.
    Pharmaceutical research, 1994, Volume: 11, Issue:9

    Topics: Adolescent; Adult; Cross-Over Studies; Erythromycin; Humans; Indomethacin; Male; Middle Aged; Monte Carlo Method; Nifedipine; Procainamide; Quinidine; Therapeutic Equivalency

1994
Evaluation of the pharmacokinetic and pharmacodynamic interaction between quinidine and nifedipine.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:8

    Topics: Administration, Oral; Adult; Blood Pressure; Drug Interactions; Drug Therapy, Combination; Female; Heart Rate; Humans; Male; Nifedipine; Quinidine

1993
Quinidine interaction with nifedipine and felodipine: pharmacokinetic and pharmacodynamic evaluation.
    Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Blood Pressure; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Double-Blind Method; Drug Interactions; Felodipine; Heart Rate; Humans; Male; Nifedipine; Quinidine; Reference Values; Regression Analysis

1993

Other Studies

75 other study(ies) available for nifedipine and quinidine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
    Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity

2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:11

    Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
    Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

    Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Humans; Male; Microsomes, Liver; Myocytes, Cardiac; Oxadiazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Vasodilator Agents

2016
Click chemistry for improvement in selectivity of quinazoline-based kinase inhibitors for mutant epidermal growth factor receptors.
    Bioorganic & medicinal chemistry letters, 2019, 02-01, Volume: 29, Issue:3

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Click Chemistry; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Structure; Mutation; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship

2019
Change in automaticity of excised, sino-atrial node by alprenolol and its dextro isomer and several drugs injected into the sinus node artery of the dog.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 230, Issue:2

    Topics: Adenosine; Alprenolol; Animals; Calcium; Dogs; Female; Heart Rate; Injections, Intra-Arterial; Male; Nifedipine; Procaine; Propranolol; Quinidine; Sinoatrial Node; Stereoisomerism; Tetrodotoxin

1977
Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog.
    Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 294, Issue:2

    Topics: Action Potentials; Anesthetics, Local; Animals; Atrioventricular Node; Benzazepines; Calcium; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Female; Heart Conduction System; In Vitro Techniques; Injections; Lidocaine; Male; Neural Conduction; Nifedipine; Procaine; Quinidine; Vasodilator Agents; Verapamil

1976
Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture.
    European journal of biochemistry, 1992, Apr-15, Volume: 205, Issue:2

    Topics: Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Doxorubicin; Drug Resistance; Gene Expression; Liver; Male; Membrane Glycoproteins; Nifedipine; Quinidine; Rats; Rats, Inbred Strains; RNA, Messenger; Verapamil; Vincristine

1992
Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes.
    Pharmaceutical research, 1992, Volume: 9, Issue:9

    Topics: Animals; Chlorpromazine; Dipyridamole; Disopyramide; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Nifedipine; Ouabain; Propranolol; Quinidine; Rats; Rats, Wistar; Sodium; Taurocholic Acid; Verapamil

1992
Effect of age and gender on the activity of human hepatic CYP3A.
    Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking

1992
Mechanisms of potassium channel block in rat alveolar epithelial cells.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Animals; Calcium; Calcium Channels; Capsaicin; Cells, Cultured; Charybdotoxin; Chlorpromazine; Epithelium; Gallopamil; Kinetics; Nifedipine; Phencyclidine; Potassium Channels; Pulmonary Alveoli; Quinidine; Rats; Scorpion Venoms; Tacrine; Tetraethylammonium Compounds; Verapamil

1990
Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans.
    Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:5 Pt 1

    Topics: Administration, Oral; Adult; Chromatography, Gas; Drug Interactions; Female; Humans; Male; Mephenytoin; Metabolic Clearance Rate; Nifedipine; Quinidine; Sparteine

1991
Characterization of metronidazole metabolism by human liver microsomes.
    Biochemical pharmacology, 1991, Apr-15, Volume: 41, Issue:8

    Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide

1991
Influence of action potential duration and resting potential on effects of quinidine, lidocaine and ethmozin on Vmax in guinea-pig papillary muscles.
    Journal of molecular and cellular cardiology, 1991, Volume: 23 Suppl 1

    Topics: Action Potentials; Animals; Female; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Moricizine; Nifedipine; Papillary Muscles; Potassium; Quinidine; Time Factors

1991
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
    Cancer research, 1990, Dec-01, Volume: 50, Issue:23

    Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil

1990
Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme.
    European journal of biochemistry, 1990, Dec-27, Volume: 194, Issue:3

    Topics: Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Genes, Fungal; Humans; Immunohistochemistry; Macrolides; Methylation; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Plasmids; Quinidine; Saccharomyces cerevisiae; Spectrophotometry; Substrate Specificity

1990
Interaction of ethanol, quinidine, and sparteine with the metabolism of nifedipine by Cunninghamella echinulata.
    Biopharmaceutics & drug disposition, 1990, Volume: 11, Issue:8

    Topics: Biotransformation; Ethanol; Fungi; Nifedipine; Quinidine; Sparteine

1990
Elucidation of the nifedipine-quinidine interaction.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:4

    Topics: Adult; Aged; Arrhythmias, Cardiac; Drug Interactions; Drug Therapy, Combination; Humans; Metabolic Clearance Rate; Middle Aged; Nifedipine; Quinidine; Risk Factors; Stroke Volume

1989
Effects of quinidine, verapamil and nifedipine on the pharmacokinetics and pharmacodynamics of digitoxin during steady state conditions.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:5

    Topics: Digitoxin; Drug Interactions; Electrocardiography; Heart; Humans; Kinetics; Nifedipine; Prospective Studies; Quinidine; Verapamil

1987
Oxidation of quinidine by human liver cytochrome P-450.
    Molecular pharmacology, 1986, Volume: 30, Issue:3

    Topics: Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethanolamines; Humans; Hydroxylation; In Vitro Techniques; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Quinidine; Rats

1986
Interaction between digoxin and commonly coadministered drugs in children.
    Pediatrics, 1985, Volume: 75, Issue:6

    Topics: Amiodarone; Child, Preschool; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Nifedipine; Quinidine; Spironolactone; Verapamil

1985
Effect of adenosine 5'triphosphate (ATP) on the isolated rectum of the rainbow lizard Agama agama.
    General pharmacology, 1985, Volume: 16, Issue:3

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Chloride; Carbachol; Dipyridamole; In Vitro Techniques; Lizards; Male; Muscle Contraction; Muscle Relaxation; Nifedipine; Potassium Chloride; Quinidine; Rectum; Theophylline

1985
Quinidine-nifedipine interaction.
    Drug intelligence & clinical pharmacy, 1985, Volume: 19, Issue:11

    Topics: Aged; Biological Availability; Drug Interactions; Humans; Lidocaine; Male; Myocardial Infarction; Nifedipine; Quinidine

1985
Calcium channel and calcium pump involved in oscillatory hyperpolarizing responses of L-strain mouse fibroblasts.
    The Journal of physiology, 1982, Volume: 327

    Topics: Animals; Biological Transport, Active; Calcium; Dose-Response Relationship, Drug; Flavonoids; Ion Channels; L Cells; Membrane Potentials; Mice; Nifedipine; Potassium; Quinidine; Quinine

1982
Nifedipine-induced alterations in serum quinidine concentrations.
    American heart journal, 1984, Volume: 108, Issue:6

    Topics: Aged; Coronary Disease; Drug Interactions; Humans; Male; Middle Aged; Nifedipine; Quinidine

1984
Experience with immunological tests in drug-induced hepatitis.
    Zeitschrift fur Gastroenterologie, 1981, Volume: 19, Issue:11

    Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Fluorescent Antibody Technique; Granuloma; Humans; Immunoglobulin A; Immunoglobulin G; Liver; Male; Microscopy, Electron; Middle Aged; Nifedipine; Prajmaline; Procainamide; Quinidine

1981
[The effect of calcium current blockers on potential-dependent potassium currents of cultured frog developing skeletal muscle cells].
    Doklady Akademii nauk, 1994, Volume: 338, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Cells, Cultured; Membrane Potentials; Muscle, Skeletal; Nifedipine; Potassium; Quinidine; Rana temporaria; Verapamil

1994
CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers.
    The Journal of biological chemistry, 1995, Mar-10, Volume: 270, Issue:10

    Topics: Animals; Carbon Monoxide; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Erythromycin; Ethinyl Estradiol; Humans; Kinetics; Mixed Function Oxygenases; Nifedipine; Protein Binding; Quinidine; Recombinant Proteins; Spodoptera; Substrate Specificity; Testosterone; Time Factors; Transfection; Warfarin

1995
Characteristics of early afterdepolarization in mouse atrial fibers.
    Science in China. Series B, Chemistry, life sciences & earth sciences, 1994, Volume: 37, Issue:1

    Topics: Aconitine; Action Potentials; Animals; Atrial Function; Benzopyrans; Cromakalim; Electrophysiology; Female; Heart; Male; Mice; Nifedipine; Pyrroles; Quinidine; Ryanodine; Tetrodotoxin

1994
Pharmacological analysis of voltage-dependent potassium currents in cultured skeletal myocytes of the frog Rana temporaria.
    General physiology and biophysics, 1995, Volume: 14, Issue:6

    Topics: 4-Aminopyridine; Animals; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Electric Conductivity; Embryo, Nonmammalian; Membrane Potentials; Muscle, Skeletal; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rana temporaria; Time Factors; Verapamil

1995
Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4.
    Biochemical pharmacology, 1997, Feb-21, Volume: 53, Issue:4

    Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Mixed Function Oxygenases; Nifedipine; Quinidine

1997
Effects of quinidine, verapamil, nifedipine and ouabain on hysteresis in atrial refractoriness in the conscious dog: an approach to ionic mechanisms.
    General pharmacology, 1999, Volume: 32, Issue:1

    Topics: Animals; Dogs; Female; Heart; Ion Channels; Male; Nifedipine; Ouabain; Quinidine; Refractory Period, Electrophysiological; Sodium-Potassium-Exchanging ATPase; Verapamil

1999
Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Hydroxylation; In Vitro Techniques; Meloxicam; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Quinidine; Thiazines; Thiazoles

1999
[The blocking effects of six antiarrhythmic drugs on transient outward current in rat ventricular myocytes].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Imipramine; Male; Myocardium; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rats; Rats, Wistar; Ventricular Function

1997
Ionic basis of the resting membrane potential and action potential in the pharyngeal muscle of Caenorhabditis elegans.
    Journal of neurophysiology, 2002, Volume: 87, Issue:2

    Topics: 4-Aminopyridine; Action Potentials; Animals; Barium; Caenorhabditis elegans; Calcium; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Chlorides; Electrophysiology; Membrane Potentials; Muscarinic Antagonists; Nifedipine; Pharyngeal Muscles; Potassium; Potassium Channel Blockers; Potassium Channels; Quinidine; Sodium; Sodium Channels; Verapamil; Veratridine

2002
Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.
    Journal of experimental botany, 2002, Volume: 53, Issue:376

    Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Azides; Berberine; Biological Transport; Cells, Cultured; Cyclosporine; Genes, MDR; Hydrogen-Ion Concentration; Lithospermum; Macrolides; Nicotiana; Nifedipine; Quinidine; Ranunculaceae; Vacuoles; Vanadates

2002
[High throughput screening method of potassium channel regulators].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:2

    Topics: 4-Aminopyridine; Animals; Barbiturates; Calcium Channel Blockers; Cromakalim; Isoxazoles; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; PC12 Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Quinidine; Rats

2004
CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Algorithms; Anti-Arrhythmia Agents; Area Under Curve; Azoles; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Forecasting; Humans; Hypnotics and Sedatives; In Vitro Techniques; Kinetics; Microsomes; Midazolam; Nifedipine; Quinidine; Substrate Specificity; Testosterone

2005
Practical application of guinea pig telemetry system for QT evaluation.
    The Journal of toxicological sciences, 2005, Volume: 30, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; Electrocardiography; Guinea Pigs; Haloperidol; Heart; Humans; Injections, Intravenous; Long QT Syndrome; Male; Nifedipine; Pimozide; Piperidines; Pyridines; Quinidine; Reproducibility of Results; Telemetry; Terfenadine; Thioridazine

2005
Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:6

    Topics: Algorithms; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Microsomes, Liver; Midazolam; Molecular Structure; Nifedipine; Quinidine; Substrate Specificity; Testosterone

2010
An electrochemical microfluidic platform for human P450 drug metabolism profiling.
    Analytical chemistry, 2010, Dec-15, Volume: 82, Issue:24

    Topics: Carbolines; Cytochrome P-450 Enzyme System; Electrochemical Techniques; Electrodes; Humans; Microfluidics; Microsomes, Liver; Nifedipine; Ondansetron; Quinidine; Substrate Specificity

2010
Inhibition of human cytochrome P450 3A4 by cholesterol.
    The Journal of biological chemistry, 2011, May-27, Volume: 286, Issue:21

    Topics: Anti-Arrhythmia Agents; Cells, Cultured; Cholesterol; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; Microsomes, Liver; Models, Biological; Nifedipine; Oxidation-Reduction; Quinidine; Vasodilator Agents

2011
Inhibition of ATP-sensitive K+ channels and L-type Ca2+ channels by amiodarone elicits contradictory effect on insulin secretion in MIN6 cells.
    Journal of pharmacological sciences, 2011, Volume: 116, Issue:1

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Membrane Potentials; Mice; Nifedipine; Osmolar Concentration; Patch-Clamp Techniques; Potassium Channel Blockers; Quinidine

2011
Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine?
    Drug metabolism and drug interactions, 2013, Volume: 28, Issue:4

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzamides; Benzimidazoles; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Indicators and Reagents; Isoenzymes; Kinetics; Microsomes, Liver; Nifedipine; Phenotype; Quinidine; Rats

2013
A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:9

    Topics: Alprazolam; Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Humans; Male; Mice; Mice, Transgenic; Microsomes, Liver; Midazolam; Nifedipine; Nitrendipine; Quinidine

2014
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Using Multielectrode Array.
    SLAS discovery : advancing life sciences R & D, 2021, Volume: 26, Issue:3

    Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cations, Divalent; Cell Differentiation; Humans; Induced Pluripotent Stem Cells; Ion Transport; Microelectrodes; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Phenethylamines; Primary Cell Culture; Quinidine; Sotalol; Sulfonamides; Tetrodotoxin; Verapamil

2021
Development and validation of dual-cardiotoxicity evaluation method based on analysis of field potential and contractile force of human iPSC-derived cardiomyocytes / multielectrode assay platform.
    Biochemical and biophysical research communications, 2021, 05-28, Volume: 555

    Topics: Calcium Channel Blockers; Cardiotoxicity; Cells, Cultured; Electrodes; Humans; Induced Pluripotent Stem Cells; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Quinidine; Toxicity Tests

2021
Pharmacological characterisation of electrocardiogram J-T
    European journal of pharmacology, 2022, Jul-15, Volume: 927

    Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil

2022