nifedipine has been researched along with quinidine in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (15.00) | 18.7374 |
| 1990's | 22 (27.50) | 18.2507 |
| 2000's | 20 (25.00) | 29.6817 |
| 2010's | 23 (28.75) | 24.3611 |
| 2020's | 3 (3.75) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Keserü, GM | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Budriesi, R; Carosati, E; Chiarini, A; Chiu, FC; Cosimelli, B; Frosini, M; Fusi, F; Ioan, P; Katneni, K; Matucci, R; Micucci, M; Saponara, S; Severi, E; Spinelli, D | 1 |
| Jang, S; Jung, D; Lee, JW; Lee, S; Min, KH; Song, J | 1 |
| Himori, N; Izumi, A | 1 |
| Narimatsu, A; Taira, N | 1 |
| Fardel, O; Guillouzo, A; Ketterer, B; Loyer, P; Ratanasavanh, D | 1 |
| Hanano, M; Iga, T; Okudaira, K; Sawada, Y; Sugiyama, Y; Yamazaki, M | 1 |
| Hunt, CM; Stave, GM; Westerkam, WR | 1 |
| DeCoursey, TE; Jacobs, ER | 1 |
| Bakker, EN; Breimer, DD; Ghabrial, H; Schellens, JH; van der Wart, HH; Wilkinson, GR | 1 |
| Lennard, MS; Loft, S; Otton, SV; Poulsen, HE; Tucker, GT | 1 |
| Chmel-Dunaj, GN; Jurevicius, J; Macianskiene, R; Muckus, K | 1 |
| Bazill, GW; Dexter, TM | 1 |
| Beaune, P; Cullin, C; Mansuy, D; Pompon, D; Renaud, JP | 1 |
| Foster, BC; McGilveray, IJ; Wilson, DL | 1 |
| Green, JA; Jarvis, RC; Kasmer, RJ; Munger, MA; Nair, R; Nara, AR; Urbancic, A | 1 |
| Kuhlmann, J | 1 |
| Blair, IA; Guengerich, FP; Müller-Enoch, D | 1 |
| Koren, G | 1 |
| Atanga, GK; Savage, AO | 1 |
| Appleby, DH; Van Lith, RM | 1 |
| Okada, Y; Tsuchiya, W; Yada, T | 1 |
| Clementi, WA; Farringer, JA; Green, JA; Linn, WA; O'Rourke, RA | 1 |
| Klejman, A; Liron, M; Livni, E; Rotmensch, HH; Sofferman, G; Weintraub, M | 1 |
| Brendel, E; Henschel, L; Hippius, M; Hoffmann, A; Sigusch, H; Tepper, J | 1 |
| Katina, IE; Luk'ianenko, VI; Nasledov, GA | 1 |
| el-Tahtawy, AA; Jackson, AJ; Ludden, TM | 1 |
| Buters, JT; Friedman, FK; Koley, AP; Markowitz, A; Robinson, RC | 1 |
| Chen, XJ; Liu, TF | 1 |
| Bowles, SK; Cardozo, L; Edwards, DJ; Reeves, RA | 1 |
| Bailey, DG; Carruthers, SG; Edgar, B; Freeman, DJ; Kreeft, JH; Melendez, LJ | 1 |
| Katina, IE; Lukyanenko, V; Nasledov, GA; Terentyev, DA | 1 |
| Friedman, FK; Koley, AP; Markowitz, A; Robinson, RC | 1 |
| Boucher, M; Chapuy, E; Chassaing, C; Lorente, P | 1 |
| Beschke, K; Ebner, T; Ludwig, E; Schmid, J | 1 |
| Liu, QY; Wang, XL | 1 |
| Cook, A; Franks, CJ; Holden-Dye, L; Pemberton, D; Vinogradova, I; Walker, RJ | 1 |
| Sakai, K; Sato, F; Shitan, N; Ueda, K; Yazaki, K | 1 |
| Pan, YP; Wang, XL; Xu, XH | 1 |
| Galetin, A; Hallifax, D; Houston, JB; Ito, K | 1 |
| Abe, J; Hamada, Y; Harada, T; Hashimoto, K; Horii, I; Sawada, Y; Shiotani, M | 1 |
| Foti, RS; Rock, DA; Wahlstrom, JL; Wienkers, LC | 1 |
| Capria, E; Collins, S; Dodhia, VR; Fantuzzi, A; Gilardi, G; Huq, E; Mak, LH; Sadeghi, SJ; Somers, G | 1 |
| Guengerich, FP; Shinkyo, R | 1 |
| Matsumoto, A; Miki, T; Nakaya, H; Nishida, A; Seino, S; Takizawa, T | 1 |
| Li, Y; Mathur, A; Maw, HH; Tweedie, DJ | 1 |
| Ishigai, M; Kato, M; Mitsui, T; Miyake, T; Nagao, S; Nemoto, T; Ogawa, K; Yamada, H | 1 |
| Bai, S; Cao, H; Chen, K; Dong, H; Ma, Y; Pei, J; Tian, L; Zhao, Y | 1 |
| Baek, J; Choi, SO; Chung, HM; Kang, KR; Kim, CY; Kim, J; Lee, JM; Lee, SG; Oh, MS; Ryu, B | 1 |
| Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H | 1 |
1 review(s) available for nifedipine and quinidine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
4 trial(s) available for nifedipine and quinidine
| Article | Year |
|---|---|
Pharmacokinetic interactions of nifedipine and quinidine.
Topics: Adult; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Drug Interactions; Half-Life; Humans; Male; Nifedipine; Quinidine | 1995 |
Comparison of single and multiple dose pharmacokinetics using clinical bioequivalence data and Monte Carlo simulations.
Topics: Adolescent; Adult; Cross-Over Studies; Erythromycin; Humans; Indomethacin; Male; Middle Aged; Monte Carlo Method; Nifedipine; Procainamide; Quinidine; Therapeutic Equivalency | 1994 |
Evaluation of the pharmacokinetic and pharmacodynamic interaction between quinidine and nifedipine.
Topics: Administration, Oral; Adult; Blood Pressure; Drug Interactions; Drug Therapy, Combination; Female; Heart Rate; Humans; Male; Nifedipine; Quinidine | 1993 |
Quinidine interaction with nifedipine and felodipine: pharmacokinetic and pharmacodynamic evaluation.
Topics: Adolescent; Adult; Analysis of Variance; Blood Pressure; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Double-Blind Method; Drug Interactions; Felodipine; Heart Rate; Humans; Male; Nifedipine; Quinidine; Reference Values; Regression Analysis | 1993 |
75 other study(ies) available for nifedipine and quinidine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Humans; Male; Microsomes, Liver; Myocytes, Cardiac; Oxadiazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Vasodilator Agents | 2016 |
Click chemistry for improvement in selectivity of quinazoline-based kinase inhibitors for mutant epidermal growth factor receptors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Click Chemistry; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Structure; Mutation; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship | 2019 |
Change in automaticity of excised, sino-atrial node by alprenolol and its dextro isomer and several drugs injected into the sinus node artery of the dog.
Topics: Adenosine; Alprenolol; Animals; Calcium; Dogs; Female; Heart Rate; Injections, Intra-Arterial; Male; Nifedipine; Procaine; Propranolol; Quinidine; Sinoatrial Node; Stereoisomerism; Tetrodotoxin | 1977 |
Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog.
Topics: Action Potentials; Anesthetics, Local; Animals; Atrioventricular Node; Benzazepines; Calcium; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Female; Heart Conduction System; In Vitro Techniques; Injections; Lidocaine; Male; Neural Conduction; Nifedipine; Procaine; Quinidine; Vasodilator Agents; Verapamil | 1976 |
Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture.
Topics: Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Doxorubicin; Drug Resistance; Gene Expression; Liver; Male; Membrane Glycoproteins; Nifedipine; Quinidine; Rats; Rats, Inbred Strains; RNA, Messenger; Verapamil; Vincristine | 1992 |
Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes.
Topics: Animals; Chlorpromazine; Dipyridamole; Disopyramide; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Nifedipine; Ouabain; Propranolol; Quinidine; Rats; Rats, Wistar; Sodium; Taurocholic Acid; Verapamil | 1992 |
Effect of age and gender on the activity of human hepatic CYP3A.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking | 1992 |
Mechanisms of potassium channel block in rat alveolar epithelial cells.
Topics: Animals; Calcium; Calcium Channels; Capsaicin; Cells, Cultured; Charybdotoxin; Chlorpromazine; Epithelium; Gallopamil; Kinetics; Nifedipine; Phencyclidine; Potassium Channels; Pulmonary Alveoli; Quinidine; Rats; Scorpion Venoms; Tacrine; Tetraethylammonium Compounds; Verapamil | 1990 |
Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans.
Topics: Administration, Oral; Adult; Chromatography, Gas; Drug Interactions; Female; Humans; Male; Mephenytoin; Metabolic Clearance Rate; Nifedipine; Quinidine; Sparteine | 1991 |
Characterization of metronidazole metabolism by human liver microsomes.
Topics: Acetone; Adult; Benzoflavones; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Male; Mephenytoin; Metronidazole; Microsomes, Liver; Middle Aged; Nifedipine; Phenacetin; Quinidine; Theophylline; Tolbutamide | 1991 |
Influence of action potential duration and resting potential on effects of quinidine, lidocaine and ethmozin on Vmax in guinea-pig papillary muscles.
Topics: Action Potentials; Animals; Female; Guinea Pigs; Lidocaine; Male; Membrane Potentials; Moricizine; Nifedipine; Papillary Muscles; Potassium; Quinidine; Time Factors | 1991 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil | 1990 |
Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme.
Topics: Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Genes, Fungal; Humans; Immunohistochemistry; Macrolides; Methylation; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Plasmids; Quinidine; Saccharomyces cerevisiae; Spectrophotometry; Substrate Specificity | 1990 |
Interaction of ethanol, quinidine, and sparteine with the metabolism of nifedipine by Cunninghamella echinulata.
Topics: Biotransformation; Ethanol; Fungi; Nifedipine; Quinidine; Sparteine | 1990 |
Elucidation of the nifedipine-quinidine interaction.
Topics: Adult; Aged; Arrhythmias, Cardiac; Drug Interactions; Drug Therapy, Combination; Humans; Metabolic Clearance Rate; Middle Aged; Nifedipine; Quinidine; Risk Factors; Stroke Volume | 1989 |
Effects of quinidine, verapamil and nifedipine on the pharmacokinetics and pharmacodynamics of digitoxin during steady state conditions.
Topics: Digitoxin; Drug Interactions; Electrocardiography; Heart; Humans; Kinetics; Nifedipine; Prospective Studies; Quinidine; Verapamil | 1987 |
Oxidation of quinidine by human liver cytochrome P-450.
Topics: Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethanolamines; Humans; Hydroxylation; In Vitro Techniques; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Quinidine; Rats | 1986 |
Interaction between digoxin and commonly coadministered drugs in children.
Topics: Amiodarone; Child, Preschool; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Nifedipine; Quinidine; Spironolactone; Verapamil | 1985 |
Effect of adenosine 5'triphosphate (ATP) on the isolated rectum of the rainbow lizard Agama agama.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Chloride; Carbachol; Dipyridamole; In Vitro Techniques; Lizards; Male; Muscle Contraction; Muscle Relaxation; Nifedipine; Potassium Chloride; Quinidine; Rectum; Theophylline | 1985 |
Quinidine-nifedipine interaction.
Topics: Aged; Biological Availability; Drug Interactions; Humans; Lidocaine; Male; Myocardial Infarction; Nifedipine; Quinidine | 1985 |
Calcium channel and calcium pump involved in oscillatory hyperpolarizing responses of L-strain mouse fibroblasts.
Topics: Animals; Biological Transport, Active; Calcium; Dose-Response Relationship, Drug; Flavonoids; Ion Channels; L Cells; Membrane Potentials; Mice; Nifedipine; Potassium; Quinidine; Quinine | 1982 |
Nifedipine-induced alterations in serum quinidine concentrations.
Topics: Aged; Coronary Disease; Drug Interactions; Humans; Male; Middle Aged; Nifedipine; Quinidine | 1984 |
Experience with immunological tests in drug-induced hepatitis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Fluorescent Antibody Technique; Granuloma; Humans; Immunoglobulin A; Immunoglobulin G; Liver; Male; Microscopy, Electron; Middle Aged; Nifedipine; Prajmaline; Procainamide; Quinidine | 1981 |
[The effect of calcium current blockers on potential-dependent potassium currents of cultured frog developing skeletal muscle cells].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Cells, Cultured; Membrane Potentials; Muscle, Skeletal; Nifedipine; Potassium; Quinidine; Rana temporaria; Verapamil | 1994 |
CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers.
Topics: Animals; Carbon Monoxide; Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Erythromycin; Ethinyl Estradiol; Humans; Kinetics; Mixed Function Oxygenases; Nifedipine; Protein Binding; Quinidine; Recombinant Proteins; Spodoptera; Substrate Specificity; Testosterone; Time Factors; Transfection; Warfarin | 1995 |
Characteristics of early afterdepolarization in mouse atrial fibers.
Topics: Aconitine; Action Potentials; Animals; Atrial Function; Benzopyrans; Cromakalim; Electrophysiology; Female; Heart; Male; Mice; Nifedipine; Pyrroles; Quinidine; Ryanodine; Tetrodotoxin | 1994 |
Pharmacological analysis of voltage-dependent potassium currents in cultured skeletal myocytes of the frog Rana temporaria.
Topics: 4-Aminopyridine; Animals; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Electric Conductivity; Embryo, Nonmammalian; Membrane Potentials; Muscle, Skeletal; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rana temporaria; Time Factors; Verapamil | 1995 |
Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4.
Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Mixed Function Oxygenases; Nifedipine; Quinidine | 1997 |
Effects of quinidine, verapamil, nifedipine and ouabain on hysteresis in atrial refractoriness in the conscious dog: an approach to ionic mechanisms.
Topics: Animals; Dogs; Female; Heart; Ion Channels; Male; Nifedipine; Ouabain; Quinidine; Refractory Period, Electrophysiological; Sodium-Potassium-Exchanging ATPase; Verapamil | 1999 |
Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Hydroxylation; In Vitro Techniques; Meloxicam; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Quinidine; Thiazines; Thiazoles | 1999 |
[The blocking effects of six antiarrhythmic drugs on transient outward current in rat ventricular myocytes].
Topics: Animals; Anti-Arrhythmia Agents; Imipramine; Male; Myocardium; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rats; Rats, Wistar; Ventricular Function | 1997 |
Ionic basis of the resting membrane potential and action potential in the pharyngeal muscle of Caenorhabditis elegans.
Topics: 4-Aminopyridine; Action Potentials; Animals; Barium; Caenorhabditis elegans; Calcium; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Chlorides; Electrophysiology; Membrane Potentials; Muscarinic Antagonists; Nifedipine; Pharyngeal Muscles; Potassium; Potassium Channel Blockers; Potassium Channels; Quinidine; Sodium; Sodium Channels; Verapamil; Veratridine | 2002 |
Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.
Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Azides; Berberine; Biological Transport; Cells, Cultured; Cyclosporine; Genes, MDR; Hydrogen-Ion Concentration; Lithospermum; Macrolides; Nicotiana; Nifedipine; Quinidine; Ranunculaceae; Vacuoles; Vanadates | 2002 |
[High throughput screening method of potassium channel regulators].
Topics: 4-Aminopyridine; Animals; Barbiturates; Calcium Channel Blockers; Cromakalim; Isoxazoles; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; PC12 Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Quinidine; Rats | 2004 |
CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions.
Topics: Algorithms; Anti-Arrhythmia Agents; Area Under Curve; Azoles; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Forecasting; Humans; Hypnotics and Sedatives; In Vitro Techniques; Kinetics; Microsomes; Midazolam; Nifedipine; Quinidine; Substrate Specificity; Testosterone | 2005 |
Practical application of guinea pig telemetry system for QT evaluation.
Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; Electrocardiography; Guinea Pigs; Haloperidol; Heart; Humans; Injections, Intravenous; Long QT Syndrome; Male; Nifedipine; Pimozide; Piperidines; Pyridines; Quinidine; Reproducibility of Results; Telemetry; Terfenadine; Thioridazine | 2005 |
Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation.
Topics: Algorithms; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Microsomes, Liver; Midazolam; Molecular Structure; Nifedipine; Quinidine; Substrate Specificity; Testosterone | 2010 |
An electrochemical microfluidic platform for human P450 drug metabolism profiling.
Topics: Carbolines; Cytochrome P-450 Enzyme System; Electrochemical Techniques; Electrodes; Humans; Microfluidics; Microsomes, Liver; Nifedipine; Ondansetron; Quinidine; Substrate Specificity | 2010 |
Inhibition of human cytochrome P450 3A4 by cholesterol.
Topics: Anti-Arrhythmia Agents; Cells, Cultured; Cholesterol; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; Microsomes, Liver; Models, Biological; Nifedipine; Oxidation-Reduction; Quinidine; Vasodilator Agents | 2011 |
Inhibition of ATP-sensitive K+ channels and L-type Ca2+ channels by amiodarone elicits contradictory effect on insulin secretion in MIN6 cells.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Membrane Potentials; Mice; Nifedipine; Osmolar Concentration; Patch-Clamp Techniques; Potassium Channel Blockers; Quinidine | 2011 |
Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine?
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzamides; Benzimidazoles; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Indicators and Reagents; Isoenzymes; Kinetics; Microsomes, Liver; Nifedipine; Phenotype; Quinidine; Rats | 2013 |
A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.
Topics: Alprazolam; Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Humans; Male; Mice; Mice, Transgenic; Microsomes, Liver; Midazolam; Nifedipine; Nitrendipine; Quinidine | 2014 |
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Using Multielectrode Array.
Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cations, Divalent; Cell Differentiation; Humans; Induced Pluripotent Stem Cells; Ion Transport; Microelectrodes; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Phenethylamines; Primary Cell Culture; Quinidine; Sotalol; Sulfonamides; Tetrodotoxin; Verapamil | 2021 |
Development and validation of dual-cardiotoxicity evaluation method based on analysis of field potential and contractile force of human iPSC-derived cardiomyocytes / multielectrode assay platform.
Topics: Calcium Channel Blockers; Cardiotoxicity; Cells, Cultured; Electrodes; Humans; Induced Pluripotent Stem Cells; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Quinidine; Toxicity Tests | 2021 |
Pharmacological characterisation of electrocardiogram J-T
Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil | 2022 |