nifedipine has been researched along with nisoldipine in 297 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 222 (74.75) | 18.7374 |
| 1990's | 47 (15.82) | 18.2507 |
| 2000's | 13 (4.38) | 29.6817 |
| 2010's | 15 (5.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herbette, LG; Mason, RP; Rhodes, DG | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Böcker, RH; Guengerich, FP | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Horinouchi, M; Komada, F; Nishiguchi, K; Ohmoto, N; Ohnishi, N; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y; Yokoyama, T | 1 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Sun, H | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Bakmiwewa, SM; Ball, HJ; Fatokun, AA; Hunt, NH; Payne, RJ; Tran, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Burburan, PJ; Matubia, VN; Parkin, DW; Ramcharan, SS; Rosario, I; Shea, TA; Stockman, BJ | 1 |
| Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y | 1 |
| Bron, S; Chambon, M; Colau, D; Majjigapu, SR; Michielin, O; Pilotte, L; Röhrig, UF; Turcatti, G; Van den Eynde, BJ; Vogel, P; Zoete, V | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Haruno, A; Kanda, A; Miyake, H; Nagasaka, M | 1 |
| Benussi, P; Marini, A; Montresor, G; Sheiban, I; Tonni, S; Trevi, GP | 1 |
| Dessy, C; Dion, R; Godfraind, T; Salomone, S; Schoevaerts, JC; Verhelst, B | 1 |
| Arita, M; Chien, Y; Frohlich, ED; Sasaki, O | 1 |
| Fitoussi, G; Nègre-Salvayre, A; Salvayre, R; Troly, M | 1 |
| Honda, K; Inagaki, C; Ohno, A; Sugino, N | 1 |
| Arena, JP; Chin, S; Kass, RS | 1 |
| Fujie, K; Handa, H; Sakamoto, W | 1 |
| Belousov, Y; Kushnaryov, V | 1 |
| Abbate, R; Boddi, M; Coppo, M; Gensini, GF; Neri Serneri, GG; Prisco, D; Rostagno, C | 1 |
| Clarke, CW; Kubik, MM | 1 |
| Ahr, G; Baunack, AR; Konrad-Dalhoff, I; Kraft, H; Kuhlmann, J; Rämsch, KD; Schmitz, H; Weihrauch, TR | 1 |
| Kazda, S | 1 |
| Hayashi, H; Miyaguchi, K; Narita, G; Nomura, H; Ogawa, S; Sotobata, I; Yasuma, F | 1 |
| Ickrath, O; Karsch, KR; Kühlkamp, V; Mauser, M; Voelker, W | 1 |
| Abe, K; Hashimoto, J; Imai, K; Imai, Y; Minami, N; Munakata, M; Nihei, M; Sakuma, H; Sasaki, S; Sekino, H | 1 |
| Kantor, M; Pedersen, TR | 1 |
| Coghlan, JP; Denton, DA; Hardy, KJ; Johnson, EI; McDougall, JG; Scoggins, BA; Wright, RD | 1 |
| Begenisich, T; Bennett, PB; Kass, RS; McKinney, LC | 1 |
| Garthoff, B; Kazda, S; Knorr, A | 1 |
| Aizawa, T; Enyeart, JJ; Hinkle, PM | 2 |
| Chesler, E; From, AH; Nelson, DP; Tolins, M; Weir, EK | 1 |
| Friedman, ME; Kaczorowski, GJ; Katz, GM; Reuben, JP; Suarez-Kurtz, G | 1 |
| Hock, CE; Lefer, AM; Whitney, CC | 1 |
| Starmer, CF | 1 |
| Deitmer, JW; Nelson, MT; Worley, JF | 1 |
| Kass, RS; Krafte, DS; Sanguinetti, MC | 1 |
| Cauvin, C; Hwang, O; van Breemen, C; Yamamoto, M | 1 |
| Gurney, AM; Nerbonne, JM | 1 |
| Armstead, WM; Hyman, AL; Kadowitz, PJ; Lippton, HL | 1 |
| Kidwell, GA; Muir, WW; Schaal, SF | 1 |
| Kass, RS; Krafte, DS | 1 |
| Gundersen, CB; Umbach, JA | 1 |
| Kato, H; Takata, Y | 2 |
| Giebisch, G; Guckian, VA; Klein-Robbenhaar, G; Klein-Robbenhaar, MT | 1 |
| Kauker, ML; Zawada, ET; Zeigler, DW | 1 |
| Lund-Johansen, P; Omvik, P | 1 |
| Palmberg, L; Thyberg, J | 1 |
| DeRoth, L; Godfraind, T; Wibo, M | 1 |
| Bodewei, R; Hering, S; Schubert, B; Wollenberger, A | 1 |
| Coghlan, JP; Denton, DA; Johnson, EI; McDougall, JG; Scoggins, BA; Wright, RD | 3 |
| Bowik, C; Chang, RJ; Smart, E; Smilowitz, H | 1 |
| Haugland, H; Lund-Johansen, P; Omvik, P | 3 |
| Bühler, FR; Nelson, MT; van Breemen, C; Zschauer, A | 1 |
| Darszon, A; de De la Torre, L; García-Soto, J; López-Colomé, AM; Mourelle, M; Ramírez, E; Vargas, I | 1 |
| Armstrong, PW; Frankel, D; Karlinsky, SJ; Moe, GW | 1 |
| Botana, L; Eleno, N; Espinosa, J | 1 |
| Bellan, JA; Kadowitz, PJ; Kerstein, MD; MacMillan, LA; McNamara, DB; Minkes, RK | 1 |
| Alcazar, JM; Bigorra, J; Garcia-Robles, R; Miranda, B; Oliet, A; Rodicio, JL; Ruilope, LM; Sancho Rof, J | 1 |
| Breimer, DD; Danhof, M; Quekel, RP; van Brummelen, P; van Harten, J | 1 |
| Bellan, JA; Hyman, AL; Kadowitz, PJ; Lippton, HL | 1 |
| Hayashi, K; Hosokawa, T; Ichihara, T; Kageyama, M; Matsumura, Y; Morimoto, S; Sasaki, Y | 1 |
| Bellan, JA; Kadowitz, PJ; Kerstein, MD; McNamara, DB; Minkes, RK | 1 |
| Brown, A; Coghlan, JP; Parkes, DG; Scoggins, BA; Spence, CD; Whitworth, JA | 1 |
| Herbette, LG; Rhodes, DG; Vant Erve, YM | 1 |
| Fu, SX; Li, YS; Zhang, HL | 1 |
| Rosenfeld, JB; Zabludowski, J | 1 |
| Chung, M; Cohen, CJ; Thomas, G | 1 |
| Hill, JA; Marchese, AC; Strauss, HC; Xie, PD | 1 |
| Bossaller, C; Hecker, H; Jost, S; Lichtlen, PR; Lippolt, P; Mogwitz, B; Nellessen, U; Rafflenbeul, W; Zwicky, P | 1 |
| Arce-Weston, B; Clark, PI; Glasser, SP | 1 |
| Kirch, W; Linde, M; Ohnhaus, EE | 2 |
| Fukuyama, M; Okabayashi, H; Takahashi, H; Yoneda, S; Yoshimura, M | 1 |
| Kaneko, Y; Kuwajima, I; Takeda, T | 1 |
| Breimer, DD; Burggraaf, J; van Brummelen, P; van Harten, J | 1 |
| Breimer, DD; Burggraaf, J; Ligthart, GJ; van Brummelen, P; van Harten, J | 1 |
| Cragoe, EJ; Jones, AW; Smith, JM | 1 |
| Brooks, HL; Hartman, JC; Kenny, D; Warltier, DC | 1 |
| Breimer, DD; Burggraaf, J; Danhof, M; van Brummelen, P; van Harten, J | 1 |
| Jones, AW; Post, JM; Smith, JM | 1 |
| Bae, SJ; Herbette, LG; Kitamura, S; Sturtevant, JM | 1 |
| Flugelman, MY; Halon, DA; Hardoff, R; Lewis, BS; Merdler, A; Shefer, A | 2 |
| Brückner, JB; Dougherty, C; Heidelmeyer, C; Schartl, M; Veit, S | 1 |
| Hasegawa, R; Homma, C; Iimura, O; Kikuchi, K; Kobayakawa, H; Komura, H; Nozawa, A; Shimamoto, K | 1 |
| Blauw, GJ; Breimer, DD; Danhof, M; Ooms, P; van Brummelen, P; van Harten, J | 1 |
| An, RH; Fu, SX; Li, YS | 1 |
| Leenen, FH; Levine, MA; Ogilvie, RI | 1 |
| Ilias, W; Steinbereithner, K | 2 |
| Duncker, DJ; Hartog, JM; Hugenholtz, PG; Saxena, PR; Verdouw, PD | 1 |
| De Feyter, PJ; Hugenholtz, PG; Serruys, PW; Soward, AL | 2 |
| Barjon, JN; Bichet, D; De Champlain, J; Juneau, C; Rouleau, JL | 1 |
| Banim, SO; Creamer, JE; O'Keefe, JC | 1 |
| Flint, NS; Opie, LH; Thandroyen, FT; Worthington, MG | 1 |
| Debatin, J; Helus, F; Knapp, WH; Ostertag, H; Sinn, HJ | 1 |
| Freedman, SB; Kelly, DT; Ogasawara, S; Ram, J; Thomson, A | 1 |
| Debbas, NM; Kovacs, IB; Sowemimo-Coker, SO; Turner, P | 1 |
| Kamei, C; Kurokawa, K; Tasaka, K | 1 |
| Debbas, NM; Jackson, SH; Turner, P | 1 |
| Hirth, C; Kazda, S; Morich, F; Stasch, JP | 1 |
| Navarro, J; Tauber, AI; Williamson, KC | 1 |
| Frais, MA; Jackson, N; Midtbo, KA; Reynolds, G; Sharma, S; Silke, B; Taylor, SH; Verma, SP | 1 |
| Ahr, G; Ahr, HJ; Karl, W; Scherling, D; Wehinger, E | 1 |
| Betteridge, DJ; Dandona, P; Hendra, TJ; Jeremy, JY; Oughton, J; Smith, CC; Yudkin, JS | 1 |
| Itoh, T; Kuriyama, H; Ueno, H | 1 |
| Elliott, HL; Jones, CR; Pasanisi, F; Reid, JL | 1 |
| Bolger, GT; Ruzycky, A; Triggle, DJ; Yousif, FB | 1 |
| Lefer, AM; Yanagisawa, A | 1 |
| Lopez, LM; Mehta, J | 1 |
| Fujita, I; Irita, K; Minakami, S; Takeshige, K; Yoshitake, J | 1 |
| Flint, GR; Herbst, CP; Otto, AC; Sweetlove, MA; van Aswegen, A; Viviers, AC | 1 |
| Friedel, HA; Sorkin, EM | 1 |
| Ramsay, LE; Waller, PC | 1 |
| Acanfora, D; Borgnino, C; Cicatiello, M; Cosentino, F; Covelluzzi, F; De Caprio, L; Gallucci, F; Leosco, D; Papa, M; Rengo, F | 1 |
| Barbieri, L; Camerini, F; Mestroni, L | 1 |
| Singer, M; Trotman, IF | 1 |
| McDonagh, PF; Roberts, DJ | 1 |
| Dandona, P; Jeremy, JY; Mikhailidis, DP | 1 |
| Kuriyama, H; Sumimoto, K | 1 |
| Figulla, HR; Kreuzer, H; Luig, H; Nieschlag, F | 1 |
| Blazek, E; Carlson, RP; Chang, J | 1 |
| Cohen, D; Eliahou, HE; Gavendo, S; Herzog, D; Kapuler, S; Schiby, G; Serban, I; Shechter, P | 1 |
| Fu, SX; Jing, CJ; Li, YS; Ren, LM | 1 |
| Ben-David, A; Cohen, D; Eliahou, HE; Hellberg, B; Herzog, D; Kapuler, S; Kogan, N; Shechter, P | 1 |
| Ahr, HJ; Krause, HP; Siefert, HM; Suwelack, D; Weber, H | 1 |
| Ahr, HJ; Krause, HP; Suwelack, D; Weber, H | 1 |
| Breimer, DD; Danhof, M; van Brummelen, P; van Harten, J; Zeegers, RR | 1 |
| Challenor, VF; Francis, JL; Roath, OS; Waller, DG | 1 |
| Bing, RJ; Saeed, M; Saito, T | 1 |
| Duncker, DJ; Saxena, PR; Verdouw, PD | 2 |
| Fu, SX; Jin, CJ; Li, YS; Ren, LM | 1 |
| Ishii, A; Nakamizo, N; Nishida, K; Oka, T | 1 |
| Karasawa, A; Kubo, K; Nakamizo, N; Oka, T | 1 |
| Alexander, J; Burkhoff, D; Sagawa, K; Schaefer, J; Schipke, JD | 1 |
| Fu, SX; Li, YL; Li, YS | 1 |
| Aschenberg, W; Bleifeld, W; Nienaber, C; Spielmann, R | 1 |
| Hokonohara, T; Kamei, C; Sugimoto, Y; Tagami, H; Tasaka, K | 1 |
| Herbst, CP; Otto, AC; Strugo, V; Sweetlove, A; van Aswegen, A | 1 |
| Fallon, JT; Knight, DR; Manders, WT; Patrick, TA; Vatner, SF | 1 |
| Graefe, KH; Rämsch, KD; Schmitz, H; Wingender, W; Ziegler, R | 1 |
| Fossheim, R; Joslyn, A; Luchowski, E; Rutledge, A; Solo, AJ; Triggle, DJ | 1 |
| Breimer, DD; Danhof, M; Lodewijks, MT; van Brummelen, P; van Harten, J | 1 |
| Brezinski, ME; Lefer, AM; Mentley, RK; Tse, E | 1 |
| Grossman, E; Rosenthal, T | 2 |
| Ahr, G; Boelaert, J; Bogaert, MG; Dammekens, H; Daneels, R; De Vriese, G; Schurgers, M; Valcke, Y | 1 |
| Harrison, GG; Morrell, DF; Wright, IG | 1 |
| Duncker, DJ; Heiligers, JP; Saxena, PR; Verdouw, PD | 1 |
| Breimer, DD; Lodewijks, MT; van Brummelen, P; van Harten, J; Wilson, JH | 1 |
| Bing, RJ; Hartmann, A; Saeed, M | 1 |
| Breimer, DD; Guyt-Scholten, JW; Lodewijks, MT; Van Brummelen, P; Van Harten, J | 1 |
| Banim, S; Caplin, JL; Dymond, DS; O'Keefe, JC | 1 |
| Kirch, W; Ohnhaus, EE; Santos, SR; Stenzel, J | 1 |
| Bowditch, J; Dow, JW; Nigdikar, SV | 1 |
| Farmer, S; Marshall, RJ; Martorana, M; Winslow, E | 1 |
| Wiederholt, M; Zadunaisky, JA | 1 |
| Dylewicz, P; Hutt, HJ; Kirch, W; Ohnhaus, EE; Santos, SR; Stenzel, J | 1 |
| Chaitman, BR; Crean, PA; Lam, J; Waters, DD | 1 |
| Deeg, P; Schmitz, H; Weiss, KH | 1 |
| Itoh, T; Kubota, Y; Kuriyama, H; Satoh, S | 1 |
| Kato, T; Nagamine, F; Nakasone, J; Noguchi, K; Sakanashi, M; Sunagawa, R | 1 |
| Buehler, FR; Burkart, F; Erne, P; Kiowski, W; Mueller, J; Pfisterer, M | 1 |
| Aschenberg, W; Bleifeld, W; Clausen, A; Fehr, A; Nienaber, CA; Spielmann, RP | 1 |
| Daniels, AR; Opie, LH | 1 |
| Eglème, C; Finet, M; Godfraind, T; Jaumin, P | 1 |
| Accettura, D; Caiati, C; Caporale, R; Chiddo, A; Lagioia, R; Mangini, SG; Mastropasqua, F; Rizzon, P; Scrutinio, D; Zanna, D | 1 |
| Challenor, VF; Francis, DA; Francis, JL; Mani, R; Roath, S; Waller, DG | 1 |
| Hatley, AA; Watts, JA; Whipple, JP | 1 |
| Kako, KJ; Takahashi, K | 2 |
| Ito, Y; Yoshitomi, T | 1 |
| Barradas, MA; Dandona, P; Jeremy, JY; Mikhailidis, DP | 1 |
| Joubert, WS; Kociszewska, VJ; Meyer, AC; Meyer, BJ; Nieuwenhuis, JJ | 1 |
| Taira, N; Takahashi, K | 1 |
| Boldt, J; Hempelmann, G; Kling, D; Moosdorf, R; von Bormann, B | 1 |
| Frais, MA; Midtbo, KA; Müller, P; Reynolds, G; Silke, B; Taylor, SH; Verma, SP | 1 |
| Beato, E; Dondi, M; Magnani, B; Melandri, G; Monetti, N; Rùggiero, S; Tartagni, F | 1 |
| Gjørup, T; Hartling, OJ; Kelbaek, H; Nielsen, SL | 1 |
| Darius, H; Klaus, W; Latta, G; Schrör, K; Ziegler, R | 1 |
| Hugenholtz, PG; Planellas, J; Serruys, PW; Soward, AL; Suryapranata, H; Vanhaleweyk, G | 1 |
| Archer, SL; Chesler, E; Weir, EK; Yankovich, RD | 1 |
| Humphreys, T; Lathrop, DA; Murphy, AM; Schwartz, A | 1 |
| Blum, R; Chaitman, BR; Crean, P; Lam, J; Waters, DD | 1 |
| Holland, JP; Lopez, LM; Mehta, JL; Rubin, MR | 1 |
| Drexler, H; Fields, RH; Flaim, SF; Zelis, R | 1 |
| Epstein, M; Horton, C; Loutzenhiser, R; Sonke, P | 1 |
| Herre, JM; Lewis, RM; Schwartz, JB | 1 |
| Altmann, A; Debatin, J; Helus, F; Knapp, WH; Layer, K; Ostertag, H; Sinn, HJ | 1 |
| Hugenholtz, PG; Jaski, BE; Planellas, J; Serruys, PW; Soward, A; Suryapranata, H; Vanhaleweyk, GL; Wijns, W | 1 |
| Charuzi, Y; Ellrodt, AG; Kimchi, A; Murata, GH; Shell, W | 1 |
| Elliott, HL; Meredith, PA; Pasanisi, F; Reid, JL | 1 |
| Barra, JG; Crottogini, AJ; de la Fuente, L; Depaoli, JR; Fischer, EC; Pichel, RH; Rodríguez Chatruc, M | 1 |
| Meredith, PA; Pasanisi, F; Reid, JL | 1 |
| Garthoff, B; Hertle, L | 1 |
| De Jong, JW | 1 |
| Frais, MA; Muller, P; Reynolds, G; Silke, B; Taylor, SH; Verma, SP | 1 |
| Bellemann, P | 1 |
| Kass, RS; Sanguinetti, MC | 2 |
| Brooks, HL; Gross, GJ; Warltier, DC; Zyvoloski, MG | 2 |
| Klein, HH; Kreuzer, H; Rauschning, W; Schwarck, H | 1 |
| Kojima, I; Kojima, K; Rasmussen, H | 1 |
| Schwartz, A; Tsai, LI; Wang, T | 1 |
| Lefer, AM; Okamatsu, S; Peck, RC | 1 |
| Tremble, P; Williams, LT | 1 |
| Saida, K; van Breemen, C | 1 |
| Itoh, T; Kanmura, Y; Kuriyama, H; Makita, Y; Suzuki, H | 1 |
| Bewtra, A; Cheng, JB; Townley, RG | 1 |
| Jentsch, TJ; Keller, S; Krolik, A; Wiederholt, M | 1 |
| Hall, CE; Hungerford, S | 1 |
| Altura, BM; Altura, BT | 2 |
| Blasini, R; Brügmann, U; Rudolph, W | 1 |
| Hess, OM; Krayenbühl, HP | 1 |
| Itoh, T; Kanmura, Y; Kuriyama, H; Suzuki, H | 1 |
| Hume, JR; Uehara, A | 1 |
| McDonagh, PF; Niven, AT; Roberts, D | 1 |
| Egloff, L; Hess, OM; Krayenbühl, HP; Maass, D; Turina, M | 1 |
| Charlier, AA; Pouleur, H; Rousseau, MF; Van den Berghe, G; Van Hoof, F; Vincent, MF | 1 |
| De Jong, JW; Huizer, T; Tijssen, JG | 1 |
| Breuer, G; Kaufmann, W; Wambach, G | 1 |
| Barr, EM; Daniell, LC; Leslie, SW | 1 |
| Poiletman, RM; Shah, AB; Shah, NS | 1 |
| Kreuzer, H; Vogt, A | 1 |
| Slager, CJ; Van Bremen, RH; Verdouw, PD; Verkeste, CM | 1 |
| Klein, HH; Kreuzer, H; Nordbeck, H | 1 |
| Francis, PD; Gaum, WE; Hannon, DW; Lathrop, DA; Millard, RW; Nakaya, H; Schwartz, A; Valle-Aguilera, JR | 1 |
| Kass, RS | 1 |
| Knorr, A | 1 |
| Garthoff, B; Kazda, S; Meyer, H; Schlossmann, K; Stoepel, K; Towart, R; Vater, W; Wehinger, E | 1 |
| Kreuzer, H; Neuhaus, KL; Vogt, A | 1 |
| Brooks, HL; Gross, GJ; Meils, CM; Warltier, DC | 1 |
| Gaum, WE; Kaplan, S; Lathrop, DA; Schwartz, A; Valle, R | 1 |
| Fagbemi, O; Parratt, JR | 2 |
| Pfaffendorf, M; Pijl, AJ; van Zwieten, PA | 1 |
| Hamaguchi, M; Imai, S; Ishibashi, T; Kato, K; Kawada, T; Mitomi, A | 1 |
| Churchill, TA; Fuller, BJ; Green, CJ | 1 |
| Mathy, MJ; Pfaffendorf, M; van Zwieten, PA | 2 |
| Dall'olio, R; Gaggi, R; Gianni, AM; Roncada, P | 1 |
| Baldelli, P; Birnbaumer, L; Neely, A; Olcese, R; Stefani, E; Wei, X | 1 |
| Nayler, WG | 1 |
| Onodera, S; Sugawara, H; Tobise, K | 1 |
| Beyer, M; Hoffmeister, HM; Mauser, M; Seipel, L | 1 |
| Buxton, BF; Casley, D; Dauer, R; Gallicchio, M; Johnston, CI; Liu, JJ; Wojta, J | 1 |
| Akhadov, ShV; Belousov, IuB; Volkov, MG | 1 |
| Campbell, SE; Kazda, S; Rakusan, K; Turek, Z | 1 |
| Cont, R; Gaggi, R; Gianni, AM | 1 |
| Saida, K; Umeda, M | 1 |
| Bagchi, D; Das, DK; Engelman, RM; Liu, X; Nath, D; Rousou, JA; Wei, Z | 1 |
| Ickrath, O; Karsch, KR; Mauser, M; Voelker, W | 1 |
| Dawkins, KD; Donaldson, KM; Waller, DG | 2 |
| Earle, KA; Hoffbrand, BI; Nievel, JG; Restrick, LJ; Simmonds, NJ | 1 |
| Chiba, K; Fukuzawa, A; Ishigai, Y; Mori, T; Shibano, T | 1 |
| Ahlner, J; Josefsson, M; Ottosson, AM | 1 |
| Kauder, WF; Watts, JA | 1 |
| Kugiyama, K; Ogawa, H; Okumura, K; Tsuchiya, T; Yasue, H | 1 |
| Fujikura, N; Masuda, Y; Shikada, K; Tanaka, S; Yokoyama, T | 2 |
| Kikuchi, K; Sugawara, H; Tobise, K | 1 |
| Amy, RM; Dolphin, PJ; Graham, SE; Russell, JC | 1 |
| Fukuta, Y; Higashino, R; Inoue, N; Jin, H; Kurimoto, T; Sato, R; Tamaki, H | 1 |
| Izawa, N; Nakamura, T; Okada, T | 1 |
| Imaizumi, Y; Muraki, K; Watanabe, M | 1 |
| Himmel, HM; Ravens, U; Stengel, W | 1 |
| Mak, IT; Weglicki, WB; Zhang, J | 1 |
| Akimoto, Y; Fujii, A; Matsumoto, H; Noji, I | 1 |
| Itou, K; Kariya, S; Kasuyama, K; Kawabata, S; Kotaki, H; Morikawa, A; Nishida, N; Ohtani, M; Seo, I; Uchino, K | 1 |
| Krzemiński, TF; Mitręga, KA; Porc, M; Varghese, B | 1 |
6 review(s) available for nifedipine and nisoldipine
| Article | Year |
|---|---|
Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranes.
Topics: Cell Membrane; Chemical Phenomena; Chemistry, Physical; Kinetics; Lipid Bilayers; Membrane Lipids; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Structure-Activity Relationship | 1991 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Calcium-induced calcium release mechanism in vascular smooth muscles--assessments based on contractions evoked in intact and saponin-treated skinned muscles.
Topics: Animals; Caffeine; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Glycerol; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Phosphatidylinositols; Polyenes; Polyethylene Glycols; Procaine; Receptors, Cell Surface | 1985 |
Nisoldipine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of angina pectoris, hypertension and related cardiovascular disorders.
Topics: Angina Pectoris; Calcium Channel Blockers; Cardiovascular Diseases; Humans; Hypertension; Nifedipine; Nisoldipine | 1988 |
[Calcium antagonists in congestive heart failure].
Topics: Calcium Channel Blockers; Cardiomyopathy, Dilated; Diltiazem; Felodipine; Heart Failure; Hemodynamics; Humans; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Verapamil | 1988 |
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cerebrovascular Circulation; Cerebrovascular Disorders; Coronary Disease; Diabetes Mellitus; Dihydropyridines; Female; Humans; Hypertension; Ketamine; Magnesium; Magnesium Deficiency; Microcirculation; Muscle, Smooth, Vascular; Muscles; Nifedipine; Nisoldipine; Nitrendipine; Nutritional Requirements; Pentobarbital; Pre-Eclampsia; Pregnancy; Pyridines; Rats; Vasoconstrictor Agents; Vasodilator Agents; Venules | 1984 |
49 trial(s) available for nifedipine and nisoldipine
| Article | Year |
|---|---|
Myocardial stunning following coronary angioplasty: protective effects of calcium-channel blockers.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Reperfusion Injury; Nifedipine; Nisoldipine; Nitrates; Random Allocation | 1992 |
The effects of nisoldipine, diltiazem, nifedipine, and verapamil on hemodynamic parameters and red blood cells-platelet interactions in patients with arterial hypertension.
Topics: Adult; Aged; Arteries; Blood Platelets; Blood Pressure; Calcium Channel Blockers; Diltiazem; Erythrocytes; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine; Verapamil | 1991 |
Nifedipine and nisoldipine in hypertensive diabetics.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Humans; Hypertension; Middle Aged; Nifedipine; Nisoldipine | 1991 |
Effect of the calcium antagonists nifedipine, nitrendipine, nimodipine and nisoldipine on oesophageal motility in man.
Topics: Administration, Oral; Adult; Calcium Channel Blockers; Double-Blind Method; Esophagogastric Junction; Esophagus; Humans; Male; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Peristalsis; Pressure | 1991 |
[Myocardial effects of the calcium antagonists nifedipine, nisoldipine and isradipine in coronary heart disease].
Topics: Blood Pressure; Calcium Channel Blockers; Coronary Disease; Heart; Heart Rate; Humans; Infusions, Intravenous; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Pyridines; Vascular Resistance | 1990 |
Nisoldipine tablets once daily versus nifedipine capsules three times daily in patients with stable effort angina pectoris pretreated with atenolol.
Topics: Adult; Angina Pectoris; Atenolol; Blood Pressure; Capsules; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Tablets | 1990 |
Central hemodynamic changes of calcium antagonists at rest and during exercise in essential hypertension.
Topics: Adult; Calcium Channel Blockers; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine; Physical Exertion; Time Factors; Verapamil | 1987 |
The efficacy and tolerability of nifedipine (NIF) and nisoldipine (NIS) both alone and combined with a beta-blocker in patients with essential hypertension: a multicenter, parallel-group study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Body Weight; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Multicenter Studies as Topic; Nifedipine; Nisoldipine; Randomized Controlled Trials as Topic | 1989 |
Silent myocardial ischemia: improvement with nisoldipine therapy.
Topics: Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Electrocardiography; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation | 1989 |
[Mechano- and impedance cardiography parameters in patients with heart failure in administration of a calcium antagonist. The significance of the Heather index].
Topics: Aged; Cardiac Output; Cardiography, Impedance; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Monitoring, Physiologic; Myocardial Contraction; Nifedipine; Nisoldipine; Plethysmography, Impedance; Random Allocation; Signal Processing, Computer-Assisted | 1989 |
Comparison of nisoldipine and atenolol in the treatment of essential hypertension.
Topics: Adult; Aged; Atenolol; Blood Pressure; Calcium Channel Blockers; Captopril; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation; Renin; Stress, Physiological | 1989 |
[Age and efficacy of new long acting calcium blocker, nisoldipine, is essential hypertension].
Topics: Adult; Age Factors; Aged; Antihypertensive Agents; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine | 1989 |
Pharmacokinetic and pharmacodynamic interactions between nisoldipine and propranolol.
Topics: Adult; Biological Availability; Calcium Channel Blockers; Double-Blind Method; Drug Interactions; Hemodynamics; Humans; Male; Nifedipine; Nisoldipine; Propranolol; Random Allocation; Receptors, Adrenergic, beta | 1988 |
Efficacy of nisoldipine combined with beta-adrenergic-blocking drugs in the treatment of chronic stable angina.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Chronic Disease; Coronary Angiography; Double-Blind Method; Drug Therapy, Combination; Exercise Test; Female; Humans; Male; Middle Aged; Nifedipine; Nisoldipine | 1987 |
Ex vivo effects of nifedipine, nisoldipine and nitrendipine on filterability of red blood cells from healthy volunteers.
Topics: Adult; Double-Blind Method; Erythrocyte Deformability; Female; Humans; Male; Nifedipine; Nisoldipine; Nitrendipine; Random Allocation | 1985 |
A comparison of the haemodynamic effects of nifedipine, nisoldipine and nitrendipine in man.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Female; Hemodynamics; Humans; Male; Myocardial Contraction; Nifedipine; Nisoldipine; Nitrendipine; Pulse; Random Allocation; Stroke Volume | 1986 |
Comparative hemodynamic dose-response effects of five slow calcium channel-blocking agents in coronary artery disease.
Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Male; Middle Aged; Nicardipine; Nifedipine; Nisoldipine; Prospective Studies; Random Allocation; Verapamil | 1987 |
The effects of nisoldipine on left ventricular filling rate in patients with ischemic heart disease measured with radionuclide gated blood pool scintigraphy.
Topics: Adult; Aged; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Radionuclide Imaging; Random Allocation; Stroke Volume | 1988 |
Rapid development of tolerance to the antihypertensive effect of nisoldipine.
Topics: Adolescent; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation | 1988 |
[Acute effects of nisoldipine in patients with stable effort angina].
Topics: Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation; Vasodilator Agents | 1988 |
Use of exercise Doppler for non-invasive haemodynamic optimization of dose and identification of poor responders to an oral anti-anginal agent. A double-blind dose-finding study of nisoldipine.
Topics: Administration, Oral; Angina Pectoris; Aorta; Blood Flow Velocity; Calcium Channel Blockers; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Hemodynamics; Humans; Nifedipine; Nisoldipine; Random Allocation; Ultrasonography | 1988 |
[Clinical and hemodynamic effects of nisoldipine and captopril in heart failure: a double-blind comparative study of long and short-term effects].
Topics: Adult; Aged; Captopril; Clinical Trials as Topic; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Long-Term Care; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation; Vasodilator Agents | 1987 |
Effect of the calcium channel blocker nisoldipine on the progression of chronic renal failure in man.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Dietary Proteins; Energy Intake; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nifedipine; Nisoldipine | 1988 |
The effect of nisoldipine on whole blood platelet aggregation in patients with Raynaud's phenomenon.
Topics: Adult; Aged; Calcium Channel Blockers; Female; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Platelet Aggregation; Raynaud Disease | 1988 |
[Comparison of the acute hemodynamic effect of nisoldipine (Bay k 5552) and nifedipine in patients with ischemia-induced left ventricular impaired function].
Topics: Adult; Aged; Calcium Channel Blockers; Cardiac Catheterization; Clinical Trials as Topic; Coronary Disease; Female; Heart Ventricles; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine | 1988 |
The "Heather Index" in impedance cardiography.
Topics: Cardiography, Impedance; Clinical Trials as Topic; Double-Blind Method; Heart Failure; Humans; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Plethysmography, Impedance; Random Allocation | 1988 |
A comparison of the acute hemodynamic effects of nifedipine and nisoldipine in patients with ischemic reduced left ventricular function.
Topics: Aged; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation | 1987 |
Plasma concentration-response relationships for some cardiovascular effects of dihydropyridines in healthy subjects.
Topics: Adult; Calcium Channel Blockers; Dose-Response Relationship, Drug; Hemodynamics; Humans; Male; Nifedipine; Nisoldipine; Nitrendipine; Random Allocation | 1988 |
Nisoldipine. Central haemodynamics at rest and during exercise in essential hypertension: acute and chronic studies.
Topics: Adult; Calcium Channel Blockers; Cardiac Output; Female; Hemodynamics; Humans; Hypertension; Male; Nifedipine; Nisoldipine; Physical Exertion; Time Factors | 1988 |
Influence of nisoldipine on haemodynamic effects and plasma levels of digoxin.
Topics: Adult; Aged; Calcium Channel Blockers; Clinical Trials as Topic; Digoxin; Double-Blind Method; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Pulse | 1986 |
Comparative antianginal effects of nisoldipine and nifedipine in patients with chronic stable angina.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation; Vasodilator Agents | 1987 |
[Nisoldipine in the treatment of essential hypertension. Efficacy and tolerance].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine | 1987 |
Monotherapy with the calcium channel antagonist nisoldipine for systemic hypertension and comparison with diuretic drugs.
Topics: Adult; Amiloride; Calcium Channel Blockers; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Headache; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Nifedipine; Nisoldipine; Random Allocation | 1987 |
Nisoldipine in primary Raynaud's phenomenon.
Topics: Adult; Aged; Calcium Channel Blockers; Drug Evaluation; Drug Tolerance; Erythrocyte Deformability; Female; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Platelet Aggregation; Raynaud Disease; Vasodilator Agents | 1987 |
[Hemodynamic effects of nisoldipine (Bay k 5552), a calcium antagonist, in coronary surgery patients].
Topics: Calcium Channel Blockers; Coronary Disease; Coronary Vasospasm; Extracorporeal Circulation; Hemodynamics; Humans; Infusions, Intravenous; Intraoperative Complications; Nifedipine; Nisoldipine | 1986 |
A haemodynamic study of the effects of combined slow-calcium channel blockade (nisoldipine) and beta-blockade (metoprolol) in coronary heart disease.
Topics: Adult; Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Drug Therapy, Combination; Hemodynamics; Humans; Metoprolol; Middle Aged; Nifedipine; Nisoldipine; Random Allocation | 1986 |
Controlled double blind trial of nisoldipine in the treatment of idiopathic Raynaud's phenomenon.
Topics: Adult; Calcium Channel Blockers; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation; Raynaud Disease | 1986 |
[Inhibition of platelet aggregation and thromboxane formation by the calcium antagonist nisoldipine following a single oral dose of 10 mg. A double-blind study in healthy probands].
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Adult; Blood Platelets; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Heart Rate; Humans; Male; Nifedipine; Nisoldipine; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1985 |
Acute coronary hemodynamic effects of equihypotensive doses of nisoldipine and diltiazem.
Topics: Adult; Aged; Benzazepines; Blood Flow Velocity; Calcium Channel Blockers; Coronary Disease; Coronary Vessels; Diltiazem; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardium; Nifedipine; Nisoldipine; Oxygen Consumption; Vascular Resistance | 1985 |
A dose-ranging, placebo-controlled, double-blind trial of nisoldipine in effort angina: duration and extent of antianginal effects.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Hemodynamics; Humans; Middle Aged; Nifedipine; Nisoldipine; Rest; Time Factors | 1985 |
The effect of nisoldipine on apparent liver blood flow and effective renal plasma flow.
Topics: Adult; Calcium Channel Blockers; Glomerular Filtration Rate; Humans; Liver Circulation; Male; Nifedipine; Nisoldipine; Renal Circulation; Time Factors | 1985 |
The pharmacodynamics and pharmacokinetics of a new calcium antagonist nisoldipine in normotensive and hypertensive subjects.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Humans; Hypertension; Kinetics; Male; Nifedipine; Nisoldipine; Vasodilator Agents | 1985 |
[Comparison of the anti-ischemia effect of nisoldipine and verapamil. Double-blind randomized cross-over and placebo-controlled acute and long-term study].
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Electrocardiography; Heart Rate; Humans; Long-Term Care; Nifedipine; Nisoldipine; Nitroglycerin; Verapamil | 1984 |
[Hypotensive properties of nisoldipine. Comparative study in essential, renal and renovascular hypertension].
Topics: Adult; Aged; Aldosterone; Calcium Channel Blockers; Electrolytes; Female; Heart Rate; Humans; Hydrocortisone; Hypertension; Hypertension, Renal; Hypertension, Renovascular; Kidney Failure, Chronic; Male; Middle Aged; Nifedipine; Nisoldipine; Renin-Angiotensin System; Vasodilator Agents | 1984 |
[The comparative effect of calcium antagonists on hemodynamics in patients with a stable form of essential hypertension (a randomized study)].
Topics: Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hypertension; Middle Aged; Nifedipine; Nisoldipine; Time Factors | 1994 |
[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease].
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Disease; Electrocardiography; Exercise Test; Felodipine; Female; Hemodynamics; Humans; Infusions, Intravenous; Isradipine; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Nifedipine; Nisoldipine | 1993 |
A comparison of nisoldipine and nifedipine, in combination with atenolol, in the management of myocardial ischaemia.
Topics: Adult; Aged; Angina Pectoris; Atenolol; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Exercise Test; Female; Humans; Male; Middle Aged; Nifedipine; Nisoldipine | 1993 |
Comparison of nisoldipine and nifedipine as additional treatment in hypertension inadequately controlled by atenolol.
Topics: Atenolol; Black People; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine; Triglycerides; White People | 1993 |
A comparison of the acute haemodynamic effects of nisoldipine and nifedipine during treatment with atenolol in patients with coronary artery disease.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Atenolol; Blood Pressure; Calcium Channel Blockers; Cardiac Catheterization; Cardiac Output; Coronary Artery Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Nifedipine; Nisoldipine; Single-Blind Method; Vascular Resistance | 1993 |
242 other study(ies) available for nifedipine and nisoldipine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450.
Topics: Chemical Phenomena; Chemistry; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; NADP; Nifedipine; Oxidation-Reduction | 1986 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Digoxin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Gene Expression; Humans; Nifedipine; Paclitaxel; RNA, Messenger; Swine; Tritium; Tumor Cells, Cultured; Verapamil; Vinblastine | 2002 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.
Topics: Carboxylic Acids; Cytochrome P-450 Enzyme System; Esters; Humans; Hydrolysis; Microsomes; Models, Molecular; Molecular Structure; Prodrugs; Quantum Theory; Signal Transduction | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Substrate Specificity | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
Identification of proton-pump inhibitor drugs that inhibit Trichomonas vaginalis uridine nucleoside ribohydrolase.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Dose-Response Relationship, Drug; Molecular Structure; N-Glycosyl Hydrolases; Omeprazole; Pantoprazole; Proton Pump Inhibitors; Rabeprazole; Structure-Activity Relationship; Trichomonas vaginalis | 2014 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2014 |
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Topics: Animals; Antifungal Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Molecular Dynamics Simulation; Molecular Structure; Structure-Activity Relationship | 2014 |
Antihypertensive effects of MPC-1304, a novel calcium antagonist, in experimental hypertensive rats and dogs.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Heart Rate; Hypertension; Hypertension, Renal; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Wistar | 1992 |
Selectivity scale of calcium antagonists in the human cardiovascular system based on in vitro studies.
Topics: Calcium; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Nifedipine; Nisoldipine; Vasoconstriction; Verapamil | 1992 |
Changes in cardiovascular mass, left ventricular pumping ability and aortic distensibility after calcium antagonists in Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Animals; Aorta; Compliance; Heart; Heart Ventricles; Hemodynamics; Hypertension; Male; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ventricular Function, Left | 1992 |
Comparative cytoprotective effect of dihydropyridine calcium channel blockers against the toxicity of oxidized low density lipoprotein for cultured lymphoid cells.
Topics: Calcium Channel Blockers; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Lipid Peroxidation; Lipoproteins, LDL; Lymphocytes; Nicardipine; Nifedipine; Nimodipine; Nisoldipine | 1992 |
Comparison of converting enzyme inhibitor and calcium channel blocker in SHR with nephrotoxic serum nephritis.
Topics: Analysis of Variance; Animals; Antibodies, Heterophile; Basement Membrane; Captopril; Glomerulonephritis; Hypertension; Kidney; Kidney Glomerulus; Male; Nifedipine; Nisoldipine; Rats; Rats, Inbred SHR | 1992 |
Block of L-type calcium channels by charged dihydropyridines. Sensitivity to side of application and calcium.
Topics: Amlodipine; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Diffusion; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Nifedipine; Nisoldipine; Receptors, Nicotinic | 1991 |
Inhibition of prostaglandin E2 and superoxide anion production in rat peritoneal macrophages by the calcium antagonists nifedipine and nisoldipine.
Topics: Animals; Arachidonic Acid; Calcimycin; Dinoprostone; Fura-2; In Vitro Techniques; Macrophages; Male; Nifedipine; Nisoldipine; Peritoneal Cavity; Rats; Rats, Inbred Strains; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
In vitro effects of two novel calcium antagonists (nitrendipine and nisoldipine) on intraplatelet calcium redistribution, platelet aggregation and thromboxane A2 formation. Comparison with diltiazem, nifedipine and verapamil.
Topics: Adult; Blood Platelets; Calcium; Calcium Channel Blockers; Diltiazem; Female; Humans; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Nitrendipine; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Verapamil | 1991 |
Inhibitory effects of nisoldipine on serotonin and potassium induced contractions of porcine coronary and femoral arteries.
Topics: Animals; Coronary Vessels; Femoral Artery; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Potassium; Serotonin; Serotonin Antagonists; Swine | 1991 |
Effects of vasodilators on venous tone in vivo in dogs.
Topics: Animals; Arterioles; Dogs; Femoral Vein; Hemodynamics; Infusions, Intravenous; Isosorbide Dinitrate; Nifedipine; Nisoldipine; Prazosin; Regression Analysis; Vasodilator Agents; Veins; Vena Cava, Inferior | 1991 |
Influence of age on the nocturnal fall of blood pressure and its modulation by long-acting calcium antagonists.
Topics: Aging; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Humans; Monitoring, Physiologic; Nifedipine; Nisoldipine; Nitrendipine | 1990 |
Ca antagonists do not alter aldosterone secretion during established Na depletion.
Topics: Adrenal Glands; Aldosterone; Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Edetic Acid; Female; Gallopamil; Hydrocortisone; Indenes; Ion Channels; Lanthanum; Nifedipine; Nisoldipine; Ryanodine; Sheep; Sodium; Verapamil | 1985 |
Delayed rectification in the calf cardiac Purkinje fiber. Evidence for multiple state kinetics.
Topics: Animals; Calcium; Cattle; Electric Conductivity; Extracellular Space; Heart Conduction System; Ion Channels; Kinetics; Membrane Potentials; Nifedipine; Nisoldipine; Potassium; Purkinje Fibers; Vasodilator Agents | 1985 |
Interference of the calcium antagonist nisoldipine with the abnormal response of vessels from hypertensive rats to alpha-adrenergic stimulation.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstriction | 1985 |
Interaction of dihydropyridine Ca2+ agonist Bay K 8644 with normal and transformed pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Ion Channels; Nifedipine; Nisoldipine; Pituitary Gland; Pituitary Neoplasms; Potassium Chloride; Prolactin; Rats | 1986 |
Pulmonary vascular tone is increased by a voltage-dependent calcium channel potentiator.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthesia; Angiotensin II; Animals; Dogs; Hemodynamics; Hypoxia; In Vitro Techniques; Ion Channels; Male; Nifedipine; Nisoldipine; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Two calcium currents in a smooth muscle cell line.
Topics: Animals; Calcium; Cell Line; Electric Conductivity; Ion Channels; Membrane Potentials; Muscle, Smooth; Nifedipine; Nisoldipine; Potassium; Rats; Sarcolemma | 1986 |
Mechanism of the pressor effect of the calcium agonist, BAY k 8644, in the intact rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetophenones; Animals; Arginine Vasopressin; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Catecholamines; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Male; Nifedipine; Nisoldipine; Nitrendipine; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Saralasin; Tetrazoles | 1986 |
Theoretical characterization of ion channel blockade: ligand binding to periodically accessible receptors.
Topics: Aminopyridines; Calcium; Calcium Channel Blockers; Electrophysiology; Ion Channels; Kinetics; Mathematics; Nifedipine; Nisoldipine; Potassium; Sodium | 1986 |
Single nisoldipine-sensitive calcium channels in smooth muscle cells isolated from rabbit mesenteric artery.
Topics: Animals; Calcium; Cell Separation; Electric Conductivity; In Vitro Techniques; Ion Channels; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Rabbits; Sarcolemma | 1986 |
Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cattle; Electric Conductivity; Heart; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Rats; Ventricular Function | 1986 |
Effects of dihydropyridines on tension and calcium-45 influx in isolated mesenteric resistance vessels from spontaneously hypertensive and normotensive rats.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Female; Ion Channels; Isradipine; Mesenteric Arteries; Nifedipine; Nisoldipine; Norepinephrine; Oxadiazoles; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance | 1987 |
Blockade of Ca2+ and K+ currents in bag cell neurons of Aplysia californica by dihydropyridine Ca2+ antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aplysia; Calcium; Calcium Channel Blockers; Dihydropyridines; Ion Channels; Kinetics; Mathematics; Neurons; Nifedipine; Nisoldipine; Potassium; Pyridines | 1987 |
Influence of nisoldipine on vascular resistance and vasoconstrictor responses in cats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Azepines; Blood Pressure; Brimonidine Tartrate; Cardiac Output; Cats; Dinoprost; Dioxanes; Electric Stimulation; Female; Idazoxan; Male; Methoxamine; Nifedipine; Nisoldipine; Norepinephrine; Phenylephrine; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; Quinoxalines; Splanchnic Circulation; Sulfonamides; Sympathetic Nervous System; Tyramine; Vascular Resistance; Vasoconstriction | 1987 |
Stereospecific effects of disopyramide enantiomers following pretreatment of canine cardiac Purkinje fibers with verapamil and nisoldipine.
Topics: Action Potentials; Animals; Disopyramide; Dogs; Heart Conduction System; In Vitro Techniques; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Stereoisomerism; Verapamil | 1987 |
Negative surface charge density near heart calcium channels. Relevance to block by dihydropyridines.
Topics: Animals; Barium; Calcium; Cattle; Electric Conductivity; Guinea Pigs; Heart; Ion Channels; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Rats; Sarcolemma; Strontium | 1987 |
Expression of an omega-conotoxin-sensitive calcium channel in Xenopus oocytes injected with mRNA from Torpedo electric lobe.
Topics: Animals; Barium; Cadmium; Calcium; Dactinomycin; Electric Organ; Ion Channels; Microinjections; Mollusk Venoms; Myocardium; Nifedipine; Nisoldipine; omega-Conotoxin GVIA; Oocytes; Poly A; Rats; RNA; RNA, Messenger; Torpedo; Xenopus laevis | 1987 |
Effects of Bay K 8644 on the electrically evoked and KCl-evoked norepinephrine release and the corresponding contraction in isolated canine saphenous veins.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Dogs; Electric Stimulation; In Vitro Techniques; Ion Channels; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Norepinephrine; Potassium Chloride; Saphenous Vein | 1987 |
Renal clearance and micropuncture studies of nisoldipine effects in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Glomerular Filtration Rate; Hypertension; Kidney; Kidney Tubules, Distal; Male; Nifedipine; Nisoldipine; p-Aminohippuric Acid; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Sodium | 1987 |
Renal tubular effect of nisoldipine, a calcium channel blocker, in rats.
Topics: Animals; Blood Pressure; Body Water; Calcium Channel Blockers; Denervation; Inulin; Kidney; Kidney Glomerulus; Kidney Tubules; Nephrons; Nifedipine; Nisoldipine; Potassium; Rats; Rats, Inbred SHR; Sodium | 1987 |
The calcium antagonist nisoldipine and the calmodulin antagonist W-7 synergistically inhibit initiation of DNA synthesis in cultured arterial smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Calcium Channel Blockers; Calmodulin; Cells, Cultured; DNA Replication; Drug Synergism; Male; Microscopy, Electron; Muscle, Smooth; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Sulfonamides | 1987 |
Pharmacologic relevance of dihydropyridine binding sites in membranes from rat aorta: kinetic and equilibrium studies.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Binding, Competitive; Calcium; Calcium Channels; Ion Channels; Isradipine; Kinetics; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Stereoisomerism | 1988 |
Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Gallopamil; Glioma; Ion Channels; Neuroblastoma; Neurons; Nifedipine; Nisoldipine; Tumor Cells, Cultured; Verapamil | 1987 |
Role of Ca2+ in response of aldosterone to stimulation by angiotensin II in vivo.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Aldosterone; Angiotensin II; Animals; Calcium; Hydrocortisone; Lanthanum; Nifedipine; Nisoldipine; Sheep; Verapamil | 1988 |
Regulation of the number of alpha-bungarotoxin binding sites in cultured chick myotubes by a 1,4 dihydropyridine calcium channel antagonist.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bungarotoxins; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Gallopamil; Kinetics; Muscles; Nifedipine; Nisoldipine; Receptors, Cholinergic | 1988 |
Central hemodynamic effects at rest and during exercise of acute and chronic treatment with nisoldipine in essential hypertension.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Nifedipine; Nisoldipine; Physical Exertion; Time Factors; Vascular Resistance | 1987 |
Calcium channels in thrombin-activated human platelet membrane.
Topics: Barium; Blood Platelets; Calcium; Calcium Channel Blockers; Cations, Divalent; Cell Membrane; Electric Conductivity; Humans; Ion Channels; Lipid Bilayers; Membrane Potentials; Nickel; Nifedipine; Nisoldipine; Sodium; Thrombin | 1988 |
Sea urchin sperm head plasma membranes: characteristics and egg jelly induced Ca2+ and Na+ uptake.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Cell Fractionation; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Ion Channels; Male; Microscopy, Electron; Nifedipine; Nisoldipine; Nitrendipine; Sea Urchins; Sodium; Sodium-Potassium-Exchanging ATPase; Sperm Head; Spermatozoa | 1988 |
Intravenous nisoldipine in severe congestive heart failure.
Topics: Adult; Aged; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Norepinephrine; Renin; Vasodilator Agents | 1988 |
Dual effect of dihydropyridines on 45Ca uptake induced by the K+ -channel blocker, 4-aminopyridin on mast cells.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Dihydropyridines; Female; Histamine Release; Ion Channels; Mast Cells; Nifedipine; Nisoldipine; Potassium; Rats; Rats, Inbred Strains | 1988 |
Analysis of regional responses to endothelin in hindquarters vascular bed of cats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Aorta, Abdominal; Blood Pressure; Calcium Channel Blockers; Cats; Endothelins; Endothelium, Vascular; Female; Male; Neuropeptide Y; Nifedipine; Nisoldipine; Peptides; Perfusion; Reference Values; Regional Blood Flow | 1989 |
Effects of nisoldipine on renal function in normal volunteers and essential hypertensive patients.
Topics: Adult; Blood Pressure; Body Weight; Diet, Sodium-Restricted; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Kidney Function Tests; Male; Natriuresis; Nifedipine; Nisoldipine; Potassium; Renal Circulation; Sodium | 1989 |
Pharmacokinetics and hemodynamic effects of long-term nisoldipine treatment in hypertensive patients.
Topics: Administration, Oral; Aged; Calcium Channel Blockers; Child; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Male; Middle Aged; Nifedipine; Nisoldipine; Time Factors; Vasodilator Agents | 1989 |
Nisoldipine inhibits vasoconstrictor responses in the cat pulmonary vascular bed.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Azepines; Calcium Channel Blockers; Cats; Female; Male; Methoxamine; Nifedipine; Nisoldipine; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Vasoconstriction; Vasodilator Agents | 1989 |
Inhibitory effect of nisoldipine on angiotensin-II-induced renal actions in anesthetized dogs.
Topics: Anesthesia; Angiotensin II; Animals; Dogs; Female; Kidney; Kidney Function Tests; Male; Nifedipine; Nisoldipine; Norepinephrine; Renal Circulation | 1989 |
Nisoldipine inhibits adrenergic responses in the hindquarters vascular bed of the cat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Cats; Drug Interactions; Female; Hindlimb; Male; Muscle Denervation; Nifedipine; Nisoldipine; Norepinephrine; Regional Blood Flow; Sympathetic Nervous System | 1989 |
Rapid haemodynamic response to adrenocorticotrophin and the role of peripheral resistance in adrenocorticotrophin-induced hypertension in conscious sheep.
Topics: Adrenocorticotropic Hormone; Animals; Calcium Channel Blockers; Consciousness; Female; Hemodynamics; Hypertension; Minoxidil; Nifedipine; Nisoldipine; Sheep; Time Factors; Vascular Resistance | 1989 |
Interaction of 1,4 dihydropyridine calcium channel antagonists with biological membranes: lipid bilayer partitioning could occur before drug binding to receptors.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Diffusion; Dogs; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nisoldipine; Rabbits; Receptors, Nicotinic; Sarcolemma; Sarcoplasmic Reticulum | 1989 |
[Protective effects of m-nisoldipine and nisoldipine on myocardial damage in working rabbit hearts after ischemia-reperfusion].
Topics: Animals; Calcium Channel Blockers; Creatine Kinase; Female; In Vitro Techniques; Isomerism; Male; Myocardial Reperfusion Injury; Myocardium; Nifedipine; Nisoldipine; Rabbits; Sodium-Potassium-Exchanging ATPase | 1989 |
A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Electric Stimulation; Female; Guinea Pigs; Ion Channels; Isoproterenol; Male; Myocardial Contraction; Myocardium; Nifedipine; Nisoldipine; Nitrendipine; Purkinje Fibers; Stimulation, Chemical; Strontium; Time Factors | 1985 |
Electrophysiologic effects of amiloride in canine Purkinje fibers: evidence for a delayed effect on repolarization.
Topics: Action Potentials; Amiloride; Animals; Calcium; Dogs; Electrophysiology; Female; Heart; In Vitro Techniques; Ion Channels; Male; Manganese; Myocardium; Nifedipine; Nisoldipine; Purkinje Fibers; Pyrazines; Sodium; Tetrodotoxin | 1985 |
Coronary vasodilation with dihydropyridines--a pharmacokinetic study.
Topics: Adult; Coronary Angiography; Coronary Disease; Coronary Vessels; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Vasodilation | 1989 |
Influence of renal function on the pharmacokinetics and cardiovascular effects of nisoldipine after single and multiple dosing.
Topics: Administration, Oral; Adult; Blood Pressure; Calcium Channel Blockers; Drug Administration Schedule; Heart Rate; Humans; Kidney Failure, Chronic; Middle Aged; Nifedipine; Nisoldipine; Norepinephrine; Parathyroid Hormone | 1989 |
Single- and multiple-dose nisoldipine kinetics and effects in the young, the middle-aged, and the elderly.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Dose-Response Relationship, Drug; Female; Half-Life; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Norepinephrine; Vasodilator Agents | 1989 |
Nisoldipine inhibition of sodium influx into aorta from aldosterone-salt-hypertensive rats.
Topics: Aldosterone; Animals; Aorta; Calcium; Calcium Channel Blockers; Hydrogen; Hypertension; Ion Exchange; Male; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride | 1989 |
Effects of nisoldipine on coronary collateral perfusion and hemodynamics in chronically instrumented dogs.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Dogs; Female; Heart Rate; Hemodynamics; Male; Nifedipine; Nisoldipine; Ultrasonics | 1989 |
The contribution of nisoldipine-induced changes in liver blood flow to its pharmacokinetics after oral administration.
Topics: Administration, Oral; Adult; Female; Humans; Liver Circulation; Liver Function Tests; Male; Middle Aged; Nifedipine; Nisoldipine | 1989 |
BRL 34915 (Cromakalim) stimulation of 42K efflux from rabbit arteries is modulated by calcium.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; Male; Nifedipine; Nisoldipine; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Tetraethylammonium Compounds; Vasoconstriction | 1989 |
The effects of calcium channel blocking drugs on the thermotropic behavior of dimyristoylphosphatidylcholine.
Topics: Calcium Channel Blockers; Calorimetry, Differential Scanning; Diltiazem; Dimyristoylphosphatidylcholine; Models, Biological; Nifedipine; Nimodipine; Nisoldipine; Thermodynamics; Verapamil | 1989 |
Effect of the second-generation calcium channel blocking drug nisoldipine on diastolic left ventricular dysfunction in heart failure.
Topics: Aged; Calcium Channel Blockers; Cardiac Output; Female; Heart; Heart Failure; Humans; Male; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Pulmonary Wedge Pressure; Radionuclide Imaging; Stroke Volume | 1989 |
Dose-related effects of intracoronary application of nisoldipine on central and peripheral circulatory parameters.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; Injections; Male; Myocardial Contraction; Nifedipine; Nisoldipine; Regional Blood Flow; Vascular Resistance | 1989 |
Effects of nisoldipine on sympathetic activity, the renin-angiotensin-aldosterone system, and water-sodium-calcium metabolism in patients with essential hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium; Calcium Channel Blockers; Creatinine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine; Renin-Angiotensin System; Sodium; Sympathetic Nervous System; Water-Electrolyte Balance | 1989 |
Variability in the pharmacokinetics of nisoldipine as caused by differences in liver blood flow response.
Topics: Administration, Oral; Adult; Blood Specimen Collection; Calcium Channel Blockers; Hemodynamics; Humans; Indocyanine Green; Injections, Intravenous; Liver Circulation; Male; Nifedipine; Nisoldipine; Sotalol | 1989 |
[Effects of m-nisoldipine on ischemic arrhythmia in conscious rats].
Topics: Animals; Arrhythmias, Cardiac; Blood Flow Velocity; Calcium Channel Blockers; Coronary Circulation; Female; Male; Myocardial Infarction; Nifedipine; Nisoldipine; Rabbits; Rats; Rats, Inbred Strains; Stereoisomerism | 1989 |
[Interaction of the calcium antagonists nifedipine and nisoldipine with the nondepolarizing muscle relaxant vecuronium bromide in an vivo rat preparation].
Topics: Animals; Calcium Channel Blockers; Drug Synergism; Muscles; Neuromuscular Nondepolarizing Agents; Nifedipine; Nisoldipine; Pancuronium; Rats; Rats, Inbred Strains; Vecuronium Bromide | 1985 |
The effects of nisoldipine (Bay K 5552) on cardiovascular performance and regional blood flow in pentobarbital-anaesthetized pigs with or without beta-adrenoceptor blockade.
Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Hemodynamics; Myocardium; Nifedipine; Nisoldipine; Oxygen Consumption; Pentobarbital; Regional Blood Flow; Swine; Vascular Resistance | 1986 |
Coronary and systemic hemodynamic effects of intravenous nisoldipine.
Topics: Adrenergic beta-Antagonists; Adult; Coronary Circulation; Coronary Vessels; Female; Hemodynamics; Humans; Lactates; Lactic Acid; Male; Middle Aged; Myocardial Infarction; Myocardium; Nifedipine; Nisoldipine; Oxygen Consumption | 1986 |
Chronic renal and neurohumoral effects of the calcium entry blocker nisoldipine in patients with congestive heart failure.
Topics: Body Water; Calcium Channel Blockers; Heart Failure; Hemodynamics; Humans; Kidney; Male; Middle Aged; Neurotransmitter Agents; Nifedipine; Nisoldipine; Time Factors | 1987 |
[Nisoldipin: a vasoselective calcium antagonist].
Topics: Calcium Channel Blockers; Humans; Nifedipine; Nisoldipine; Vasodilator Agents | 1987 |
Arrhythmogenic action of alpha 1-adrenoceptor stimulation in normoxic rat ventricular myocardium: influence of nisoldipine, reduced extracellular Ca2+ and ryanodine.
Topics: Adrenergic alpha-Agonists; Alkaloids; Animals; Arrhythmias, Cardiac; Azepines; Calcium; Calcium Channel Blockers; Heart; Male; Methoxamine; Nifedipine; Nisoldipine; Prazosin; Rats; Rats, Inbred Strains; Ryanodine | 1987 |
Increased thermal response to ultrasound in the Walker carcinosarcoma treated with vasoactive drugs.
Topics: Animals; Body Temperature; Carcinoma 256, Walker; Hyperthermia, Induced; Nifedipine; Nisoldipine; Rats; Regional Blood Flow; Serotonin; Ultrasonic Therapy; Xenon Radioisotopes | 1989 |
Effects of nisoldipine on systemic and leg blood flow, oxygen transport and metabolism, and hemodynamics during exercise in effort angina pectoris.
Topics: Adult; Angina Pectoris; Cardiac Output; Heart Rate; Hemodynamics; Humans; Lactates; Lactic Acid; Leg; Male; Middle Aged; Nifedipine; Nisoldipine; Oxygen; Oxygen Consumption; Physical Exertion; Pulmonary Wedge Pressure; Regional Blood Flow; Vascular Resistance; Vasodilator Agents | 1989 |
Hypotensive effects of dihydropyridine derivatives.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Hydralazine; Nicardipine; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1985 |
Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Hypertension; Male; Nifedipine; Nisoldipine; Rats; Rats, Inbred SHR | 1987 |
Nisoldepine inhibits formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe) receptor-coupled calcium transport in human neutrophils.
Topics: Adult; Biological Transport; Calcium; Calcium Channel Blockers; Humans; In Vitro Techniques; Isradipine; Neutrophils; Nifedipine; Nisoldipine; Oxadiazoles; Receptors, Formyl Peptide; Receptors, Immunologic | 1987 |
Pharmacokinetics of nisoldipine. III. Biotransformation of nisoldipine in rat, dog, monkey, and man.
Topics: Administration, Oral; Animals; Biotransformation; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Thin Layer; Dogs; Female; Humans; Injections, Intravenous; Macaca mulatta; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains; Specific Pathogen-Free Organisms; Vasodilator Agents | 1988 |
Ex vivo platelet studies following oral nisoldipine in normotensive insulin-dependent diabetics and non-diabetic controls.
Topics: Adenosine Diphosphate; beta-Thromboglobulin; Blood Platelets; Catecholamines; Collagen; Diabetes Mellitus, Type 1; Epinephrine; Humans; In Vitro Techniques; Nifedipine; Nisoldipine; Physical Exertion; Platelet Aggregation; Platelet Factor 4; Reference Values; Thromboxane A2 | 1988 |
Effects of verapamil and nisoldipine on human platelets: in vivo and in vitro studies.
Topics: Adult; Blood Platelets; Calcium Channel Blockers; Humans; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Platelet Aggregation; Receptors, Adrenergic, alpha; Verapamil; Yohimbine | 1985 |
Ca2+ channel antagonist actions in bladder smooth muscle: comparative pharmacologic and [3H]nitrendipine binding studies.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Guinea Pigs; In Vitro Techniques; Male; Microsomes; Muscarine; Muscle Contraction; Muscle, Smooth; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Potassium; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Urinary Bladder | 1985 |
Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockers in vitro.
Topics: Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Drug Synergism; Gallopamil; Male; Neuromuscular Junction; Nifedipine; Nisoldipine; Pancuronium; Rats; Rats, Inbred Strains; Synaptic Transmission; Verapamil | 1985 |
Inhibition of leukotriene actions by the calcium channel blocker, nisoldipine.
Topics: Animals; Calcium Channel Blockers; Cats; Coronary Vessels; Heart; In Vitro Techniques; Leukotriene B4; Lung; Male; Nifedipine; Nisoldipine; SRS-A; Vasoconstriction | 1986 |
Calcium-blocker withdrawal phenomenon: increase in affinity of alpha 2 adrenoceptors for agonist as a potential mechanism.
Topics: Adult; Angina Pectoris; Blood Platelets; Calcium Channel Blockers; Coronary Disease; Epinephrine; Humans; Male; Middle Aged; Myocardial Infarction; Nifedipine; Nisoldipine; Platelet Aggregation; Receptors, Adrenergic, alpha | 1986 |
Calcium channel antagonist induced inhibition of superoxide production in human neutrophils. Mechanisms independent of antagonizing calcium influx.
Topics: Calcium; Calcium Channel Blockers; Diltiazem; Egtazic Acid; Humans; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Nifedipine; Nisoldipine; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Verapamil | 1986 |
Prevention of transcoronary macromolecular leakage after ischemia-reperfusion by the calcium entry blocker nisoldipine. Direct observations in isolated rat hearts.
Topics: Animals; Capillaries; Coronary Circulation; Coronary Disease; Coronary Vessels; Extravasation of Diagnostic and Therapeutic Materials; Fluorescein-5-isothiocyanate; Fluoresceins; Nifedipine; Nisoldipine; Nitroglycerin; Perfusion; Rats; Serum Albumin, Bovine; Thiocyanates; Vascular Resistance; Vasodilation | 1986 |
The effect of nifedipine, nimodipine and nisoldipine on agonist- and trauma-stimulated vascular prostacyclin synthesis in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium Channel Blockers; Epinephrine; Epoprostenol; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Wounds and Injuries | 1986 |
Mobilization of free Ca2+ measured during contraction-relaxation cycles in smooth muscle cells of the porcine coronary artery using quin2.
Topics: Acetylcholine; Aminoquinolines; Animals; Caffeine; Calcium; Calcium Channel Blockers; Coronary Vessels; Egtazic Acid; Fluorescent Dyes; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Potassium; Swine | 1986 |
Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Carbon Radioisotopes; Dose-Response Relationship, Drug; Humans; Inflammation; Macrophages; Male; Mice; Nifedipine; Nisoldipine; Peritoneal Cavity; Phospholipases; Phospholipases A; Phospholipases A2; SRS-A; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1987 |
The control of hypertension and its effect on renal function in rat remnant kidney.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Creatinine; Dietary Proteins; Dihydralazine; Female; Hypertension; Kidney Failure, Chronic; Male; Nephrectomy; Nifedipine; Nisoldipine; Proteinuria; Rats; Rats, Inbred Strains | 1988 |
[Effects of m-nisoldipine and nisoldipine on hemodynamics in anesthetized dogs].
Topics: Animals; Calcium Channel Blockers; Dogs; Hemodynamics; Isomerism; Nifedipine; Nisoldipine; Vascular Resistance | 1988 |
Pharmacokinetics of nisoldipine. I. Absorption, concentration in plasma, and excretion after single administration of [14C]nisoldipine in rats, dogs, monkey, and swine.
Topics: Absorption; Administration, Oral; Animals; Blood Proteins; Calcium Channel Blockers; Dogs; Female; Injections, Intravenous; Macaca mulatta; Male; Nifedipine; Nisoldipine; Protein Binding; Rats; Rats, Inbred Strains; Swine; Tissue Distribution; Vasodilator Agents | 1988 |
Pharmacokinetics of nisoldipine. II. Distribution to and elimination from tissues and organs following single or repeated administration of [14C]nisoldipine to rats and dogs.
Topics: Administration, Oral; Animals; Autoradiography; Calcium Channel Blockers; Dogs; Female; Injections, Intravenous; Lactation; Male; Maternal-Fetal Exchange; Milk; Nifedipine; Nisoldipine; Pregnancy; Rats; Rats, Inbred Strains; Tissue Distribution; Vasodilator Agents | 1988 |
The influence of infusion rate on the pharmacokinetics and haemodynamic effects of nisoldipine in man.
Topics: Adsorption; Adult; Female; Hemodynamics; Humans; Indocyanine Green; Infusions, Intravenous; Liver Circulation; Male; Nifedipine; Nisoldipine; Vasodilator Agents | 1988 |
Effect of nisoldipine on large coronary arteries in situ: inhibition of vasoconstriction induced by vasopressin.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Vessels; Hemodynamics; Male; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Rabbits; Vasoconstriction; Vasopressins | 1988 |
Systemic haemodynamics of dihydropyridine derivatives in conscious pigs with or without propranolol.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Nifedipine; Nimodipine; Nisoldipine; Propranolol; Swine; Vasodilation | 1988 |
[Cardiovascular action of m-nisoldipine in anaesthetized rabbits and guinea pigs].
Topics: Animals; Aorta; Blood Pressure; Coronary Circulation; Female; Guinea Pigs; Heart Rate; Hemodynamics; Male; Muscle Contraction; Nifedipine; Nisoldipine; Rabbits; Vasodilator Agents | 1988 |
Slow dissociation of the new slow-onset and long-acting calcium antagonist benidipine hydrochloride from 3H-nitrendipine binding sites.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Male; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred Strains | 1988 |
Antihypertensive effects of intravenous administration of benidipine hydrochloride and some other calcium antagonists in conscious, spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Injections, Intravenous; Male; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Verapamil | 1988 |
Effect of nisoldipine on coronary resistance, contractility and oxygen consumption of the isolated blood-perfused canine left ventricle.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Coronary Vessels; Dogs; Heart Ventricles; In Vitro Techniques; Myocardial Contraction; Myocardium; Nifedipine; Nisoldipine; Oxygen Consumption; Perfusion; Vascular Resistance | 1988 |
[Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmia in hearts of rats].
Topics: Animals; Arrhythmias, Cardiac; Calcium; Fatty Acids, Nonesterified; Free Radicals; Isomerism; Male; Myocardial Reperfusion Injury; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains | 1988 |
Antihypertensive effects of nisoldipine and reference drugs in certain types of hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Hypertension; Hypertension, Renal; Male; Nifedipine; Nisoldipine; Pulse; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renin | 1987 |
Effects of calcium channel blocker on responses of blood flow, function, arrhythmias, and extent of infarction following reperfusion in conscious baboons.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Creatine Kinase; Hemodynamics; Isoenzymes; Ligation; Myocardial Infarction; Nifedipine; Nisoldipine; Papio; Perfusion; Regional Blood Flow | 1988 |
Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series.
Topics: Animals; Calcium Channel Blockers; Guinea Pigs; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Structure-Activity Relationship; X-Ray Diffraction | 1988 |
Pharmacokinetics and hemodynamic effects of nisoldipine and its interaction with cimetidine.
Topics: Administration, Oral; Adult; Blood Pressure; Calcium Channel Blockers; Cimetidine; Half-Life; Heart Rate; Humans; Injections, Intravenous; Nifedipine; Nisoldipine | 1988 |
Cardioprotective actions of nisoldipine in postreperfusion myocardial ischemia.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cats; Coronary Circulation; Coronary Disease; Creatine Kinase; Electrocardiography; Heart Rate; Male; Myocardium; Nifedipine; Nisoldipine; Oxygen Consumption; Perfusion; Time Factors | 1988 |
Effect of the second-generation calcium channel blocker nisoldipine on left ventricular contractility in cardiac failure.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Cardiac Volume; Heart Failure; Heart Ventricles; Humans; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Stroke Volume | 1988 |
Nisoldipine: a replacement therapy for nifedipine in the treatment of severe hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine | 1988 |
Pharmacokinetics of nisoldipine in renal dysfunction.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Female; Heart Rate; Humans; Kidney Diseases; Male; Middle Aged; Nifedipine; Nisoldipine; Renal Dialysis | 1988 |
The effects of calcium channel blocking drugs on halothane initiation of malignant hyperthermia in MHS swine and on the established syndrome.
Topics: Anesthesia, General; Animals; Calcium Channel Blockers; Diltiazem; Flunarizine; Halothane; Malignant Hyperthermia; Nifedipine; Nisoldipine; Swine; Verapamil | 1988 |
Nisoldipine and perfusion of post-stenotic myocardium in conscious pigs with different degrees of concentric stenosis.
Topics: Animals; Aortic Valve Stenosis; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Heart Rate; Hemodynamics; In Vitro Techniques; Nifedipine; Nisoldipine; Swine; Vascular Resistance | 1988 |
Nisoldipine: kinetics and effects on blood pressure and heart rate in patients with liver cirrhosis after intravenous and oral administration.
Topics: Administration, Oral; Adolescent; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Female; Half-Life; Heart Rate; Humans; Injections, Intravenous; Liver Cirrhosis; Male; Middle Aged; Nifedipine; Nisoldipine | 1988 |
Effect of nisoldipine on de-endothelialized large coronary artery in isolated working rabbit hearts.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Endothelium, Vascular; Heart; Histamine; In Vitro Techniques; Male; Muscle Contraction; Myocardium; Nifedipine; Nisoldipine; Oxygen Consumption; Rabbits | 1987 |
The effects of nisoldipine alone and in combination with beta-adrenoceptor blockade on systemic haemodynamics and myocardial performance in conscious pigs.
Topics: Animals; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Hemodynamics; Myocardial Contraction; Nifedipine; Nisoldipine; Propranolol; Regional Blood Flow; Swine; Vascular Resistance | 1987 |
Gas chromatographic determination of nisoldipine and one of its metabolites in plasma.
Topics: Adult; Calcium Channel Blockers; Chromatography, Gas; Drug Stability; Half-Life; Humans; Light; Male; Mass Spectrometry; Nifedipine; Nisoldipine; Solvents | 1987 |
Effects of nisoldipine on left ventricular function during exercise or cold pressor stress.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Cold Temperature; Coronary Disease; Exercise Test; Female; Heart Function Tests; Heart Rate; Humans; Male; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Stroke Volume; Vasodilator Agents | 1987 |
The hypotensive effect of nisoldipine in renovascular hypertensive rats.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Hypertension, Renovascular; Nifedipine; Nisoldipine; Rats | 1986 |
Acute and chronic hemodynamic effects of nisoldipine in essential hypertension at rest and during exercise.
Topics: Female; Hemodynamics; Humans; Hypertension; Male; Nifedipine; Nisoldipine; Physical Exertion | 1986 |
Nisoldipine, a new calcium antagonist, elevates plasma levels of digoxin.
Topics: Adult; Aged; Calcium Channel Blockers; Digoxin; Double-Blind Method; Drug Interactions; Female; Humans; Kinetics; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation; Stroke Volume; Vasodilator Agents | 1987 |
Calcium antagonists and adenine nucleotide metabolism in rat heart.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Bepridil; Calcium Channel Blockers; Heart; Myocardium; Nifedipine; Nisoldipine; Pyrrolidines; Rats; Verapamil | 1986 |
The effects of bepridil compared with calcium antagonists on rat and rabbit aorta.
Topics: Animals; Aorta, Thoracic; Bepridil; Calcium Channel Blockers; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Phenylephrine; Potassium; Pyrrolidines; Rabbits; Rats; Species Specificity | 1986 |
Effect of calcium antagonist compound nisoldipine on transepithelial electrical parameters in the isolated frog cornea.
Topics: Animals; Calcium Channel Blockers; Chlorides; Cornea; Dose-Response Relationship, Drug; In Vitro Techniques; Membrane Potentials; Nifedipine; Nisoldipine; Rana catesbeiana | 1986 |
Mechanisms of the Ba2+-induced contraction in smooth muscle cells of the rabbit mesenteric artery.
Topics: Animals; Barium; Biomechanical Phenomena; Caffeine; Calcium; Contractile Proteins; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Potassium; Rabbits | 1987 |
Comparison of vasodilating effects of nisoldipine and nifedipine in anesthetized open-chest dogs.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Dogs; Electrocardiography; Female; Hemodynamics; Male; Nifedipine; Nisoldipine; Vasodilator Agents | 1986 |
Arterial vasodilator, systemic and coronary hemodynamic effects of nisoldipine in congestive heart failure secondary to ischemic or dilated cardiomyopathy.
Topics: Aged; Calcium Channel Blockers; Cardiomyopathy, Dilated; Coronary Circulation; Forearm; Heart Failure; Hemodynamics; Humans; Middle Aged; Nifedipine; Nisoldipine; Vasodilator Agents | 1987 |
Comparison of the acute hemodynamic response to intravenous nisoldipine (Bay k 5552) and intravenous nifedipine for left ventricular dysfunction secondary to myocardial infarction.
Topics: Aged; Depression, Chemical; Female; Heart Ventricles; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Nifedipine; Nisoldipine; Radionuclide Angiography; Thermodilution | 1987 |
The actions of nifedipine and nisoldipine on the contractile activity of human coronary arteries and human cardiac tissue in vitro.
Topics: Adolescent; Adult; Aged; Child; Coronary Vessels; Humans; In Vitro Techniques; Isoproterenol; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Serotonin Antagonists; Vasoconstriction; Vasodilator Agents | 1987 |
[Acute effects of various doses of nisoldipine in stable exertional angina].
Topics: Adult; Aged; Angina Pectoris; Dose-Response Relationship, Drug; Exercise Test; Female; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Random Allocation; Vasodilator Agents | 1987 |
A low concentration of nisoldipine reduces ischemic heart injury: enhanced reflow and recovery of contractile function without energy preservation during ischemia.
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Coronary Circulation; Coronary Disease; Energy Metabolism; Heart Rate; Myocardial Contraction; Nifedipine; Nisoldipine; Phosphocreatine; Rats; Rats, Inbred Strains | 1987 |
The effects of myocardial ischemia and nisoldipine pretreatment on the asymmetric distribution of phosphatidylethanolamine in a canine heart sarcolemmal preparation.
Topics: Animals; Calcium Channel Blockers; Cell Fractionation; Chlorpromazine; Coronary Disease; Dogs; Female; Kinetics; Male; Myocardium; Nifedipine; Nisoldipine; Phosphatidylethanolamines; Phospholipids; Sarcolemma | 1986 |
Membrane and contractile properties of the dog ciliary muscle.
Topics: Animals; Carbachol; Dogs; Electric Stimulation; Evoked Potentials; Female; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Nifedipine; Nisoldipine | 1986 |
Effects of verapamil and nisoldipine on human platelets: in vivo and in vitro studies.
Topics: Calcium Channel Blockers; Humans; In Vitro Techniques; Nifedipine; Nisoldipine; Physical Exertion; Platelet Aggregation; Verapamil | 1986 |
Dihydropyridine calcium antagonists depress the amplitude of the plasma melatonin cycle in baboons.
Topics: Animals; Calcium Channel Blockers; Male; Melatonin; Nifedipine; Nisoldipine; Nitrendipine; Papio; Verapamil | 1986 |
Cardiovascular profiles of the calcium antagonists nisoldipine and nifedipine in the blood-perfused dog heart.
Topics: Animals; Atrioventricular Node; Calcium Channel Blockers; Cardiac Pacing, Artificial; Coronary Circulation; Dogs; Female; Heart; Hemodynamics; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Sinoatrial Node | 1986 |
Maintenance of increased coronary blood flow in excess of demand by nisoldipine administered as an intravenous infusion.
Topics: Coronary Circulation; Female; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardium; Nifedipine; Nisoldipine; Oxygen Consumption | 1986 |
Comparative study on acute antihypertensive effects and pharmacokinetics of nisoldipine, nifedipine, nimodipine and nicardipine administered orally to conscious renal hypertensive dogs.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hydralazine; Hypertension, Renal; Kinetics; Male; Nicardipine; Nifedipine; Nimodipine; Nisoldipine; Time Factors | 1986 |
Effects of oral nisoldipine in ischemic heart disease. A radioisotopic study.
Topics: Administration, Oral; Cardiovascular System; Coronary Disease; Evaluation Studies as Topic; Exercise Test; Heart Rate; Humans; Male; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Radioisotopes; Stroke Volume | 1986 |
Comparative effects of nisoldipine, nifedipine and bepridil on experimental pulmonary hypertension.
Topics: Animals; Bepridil; Blood Gas Analysis; Calcium Channel Blockers; Dinoprost; Dogs; Female; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Male; Nifedipine; Nisoldipine; Prostaglandins F; Pyrrolidines | 1985 |
Effects of bepridil on force development and transmembrane electrical activity of adult canine Purkinje strands: comparison with nisoldipine and lidocaine.
Topics: Animals; Bepridil; Calcium Channel Blockers; Dogs; Female; Heart Conduction System; Lidocaine; Male; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Pyrrolidines; Time Factors | 1985 |
Dihydropyridine Ca2+ antagonists: potent inhibitors of secretion from normal and transformed pituitary cells.
Topics: Animals; Calcium Channel Blockers; Cell Line; Growth Hormone; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Pituitary Gland; Pituitary Neoplasms; Potassium Chloride; Prolactin; Rats; Thyrotropin-Releasing Hormone; Verapamil | 1985 |
Improvement in exercise performance with nisoldipine, a new second-generation calcium blocker, in stable angina patients.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Exercise Test; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Nitroglycerin; Time Factors | 1985 |
Effects of nisoldipine on cardiocirculatory dynamics and cardiac output distribution in conscious rats at rest and during treadmill exercise.
Topics: Animals; Cardiac Output; Coronary Circulation; Male; Nifedipine; Nisoldipine; Physical Exertion; Rats; Rats, Inbred Strains; Regional Blood Flow; Vascular Resistance | 1985 |
Reversal by the calcium antagonist nisoldipine of norepinephrine-induced reduction of GFR: evidence for preferential antagonism of preglomerular vasoconstriction.
Topics: Animals; Glomerular Filtration Rate; Kidney; Male; Nifedipine; Nisoldipine; Norepinephrine; Perfusion; Phentolamine; Rats; Rats, Inbred Strains; Renal Circulation; Vasoconstriction | 1985 |
The electrophysiologic effects of nisoldipine in the conscious dog.
Topics: Animals; Atrioventricular Node; Blood Pressure; Calcium Channel Blockers; Cardiovascular Physiological Phenomena; Cardiovascular System; Dogs; Electrocardiography; Electrophysiology; Hemodynamics; Nifedipine; Nisoldipine; Sinoatrial Node | 1985 |
Selective drug-induced reduction of blood flow in tumor transplants.
Topics: Animals; Calcium Channel Blockers; Hyperthermia, Induced; Neoplasm Transplantation; Neoplasms, Experimental; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains; Regional Blood Flow; Serotonin | 1985 |
Acute effects of intravenous nisoldipine on left ventricular function and coronary hemodynamics.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Coronary Circulation; Female; Heart; Heart Rate; Heart Ventricles; Hemodynamics; Humans; Injections, Intravenous; Male; Middle Aged; Nifedipine; Nisoldipine; Time Factors | 1985 |
Salutary hemodynamic and sustained clinical beneficial effects of nisoldipine, a new calcium channel blocker, in patients with recurrent ischemia and severe heart failure.
Topics: Aged; Calcium Channel Blockers; Coronary Disease; Heart Failure; Hemodynamics; Humans; Male; Mitral Valve Insufficiency; Nifedipine; Nisoldipine | 1985 |
The effect of the new calcium antagonist nisoldipine (BAY k-5552) on myocardial infarct size limitation in conscious dogs.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Calcium Channel Blockers; Dogs; Female; Heart Rate; Male; Myocardial Infarction; Nifedipine; Nisoldipine; Time Factors | 1985 |
Calcium channel blocker nisoldipine limits ischemic damage in rat kidney.
Topics: Animals; Calcium Channel Blockers; Ischemia; Kidney; Male; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains | 1985 |
Timely administration of nisoldipine essential for prevention of myocardial ATP catabolism.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium Channel Blockers; Coronary Circulation; Depression, Chemical; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Nifedipine; Nisoldipine; Perfusion; Purines; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Haemodynamic dose-response effects of intravenous nisoldipine in coronary artery disease.
Topics: Adult; Aged; Calcium Channel Blockers; Cardiac Output; Coronary Disease; Dose-Response Relationship, Drug; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Oxygen Consumption; Pulmonary Circulation; Vascular Resistance | 1985 |
Interaction of the calcium channel activating 3H-BAY K 8644 and inhibiting 3H-verapamil with specific receptor sites on cultured beating myocardial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium; Calcium Channel Blockers; Cells, Cultured; Kinetics; Myocardial Contraction; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Receptors, Drug; Verapamil | 1984 |
Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.
Topics: Animals; Binding Sites; Cattle; Dihydropyridines; Electrophysiology; Heart Conduction System; Ion Channels; Membrane Potentials; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Purkinje Fibers; Pyridines; Verapamil | 1984 |
Ischemia-induced changes in sarcolemmal (Na+, K+)-ATPase, K+-pNPPase, sialic acid, and phospholipid in the dog and effects of the nisoldipine and chlorpromazine treatment.
Topics: 4-Nitrophenylphosphatase; Animals; Chlorpromazine; Coronary Disease; Dogs; Electrocardiography; Female; Male; Membrane Lipids; N-Acetylneuraminic Acid; Nifedipine; Nisoldipine; Phospholipids; Sarcolemma; Sialic Acids; Sodium-Potassium-Exchanging ATPase | 1984 |
Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: systemic and coronary hemodynamics with and without combined beta adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dogs; Female; Heart Rate; Hemodynamics; Hydralazine; Male; Nifedipine; Nisoldipine; Nitrendipine; Propranolol; Vasodilator Agents | 1984 |
Effect of nisoldipine on electrophysiological parameters in patients pretreated with beta-blockers.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiac Catheterization; Coronary Disease; Electrophysiology; Female; Heart Conduction System; Humans; Male; Middle Aged; Nifedipine; Nisoldipine | 1984 |
Dihydropyridine calcium agonist and antagonist effects on aldosterone secretion.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Aldosterone; Angiotensin II; Animals; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Dantrolene; Ion Channels; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Potassium; Stimulation, Chemical | 1984 |
Effects of verapamil, diltiazem, nisoldipine and felodipine on sarcoplasmic reticulum.
Topics: Animals; Calcium Channel Blockers; Calcium-Transporting ATPases; Centrifugation, Density Gradient; Diltiazem; Dogs; Felodipine; In Vitro Techniques; Microsomes; Muscles; Myocardium; Nifedipine; Nisoldipine; Potassium Chloride; Rabbits; Sarcoplasmic Reticulum; Species Specificity; Verapamil | 1984 |
Effect of calcium channel blockers on arachidonate-induced sudden death in rabbits.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Death, Sudden; Ion Channels; Liver; Lysosomes; Nifedipine; Nisoldipine; Pancreas; Pyridines; Rabbits; Thromboxane B2; Verapamil | 1981 |
Binding of a calcium antagonist, [3H]nitrendipine, to high affinity sites in bovine aortic smooth muscle and canine cardiac membranes.
Topics: Animals; Aorta; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cattle; Dogs; Heart Ventricles; Ion Channels; Membranes; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrendipine; Pyridines | 1982 |
Mechanism of Ca++ antagonist-induced vasodilation. Intracellular actions.
Topics: Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Ion Channels; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Norepinephrine; Rabbits; Saponins; Vasodilator Agents | 1983 |
Effects of nifedipine derivatives on smooth muscle cells and neuromuscular transmission in the rabbit mesenteric artery.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Female; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Rabbits; Synaptic Transmission | 1983 |
Identification of calcium antagonist receptor binding sites using (3H)nitrendipine in bovine tracheal smooth muscle membranes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cattle; Cromolyn Sodium; Kinetics; Muscle, Smooth; Nifedipine; Nisoldipine; Nitrendipine; Receptors, Nicotinic; Trachea; Verapamil | 1984 |
Photoalteration of calcium channel blockade in the cardiac Purkinje fiber.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Cattle; Heart Conduction System; In Vitro Techniques; Ion Channels; Light; Nifedipine; Nisoldipine; Purkinje Fibers | 1984 |
The calcium antagonist nisoldipine stimulates the electrolyte transport of the isolated frog skin.
Topics: Amiloride; Animals; Calcium; Calcium Channel Blockers; Electric Conductivity; In Vitro Techniques; Nifedipine; Nisoldipine; Rana esculenta; Skin; Sodium; Water-Electrolyte Balance | 1984 |
Prevention of spontaneous and glucocorticoid hypertension in rats by nisoldipine.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cortisone; Glucocorticoids; Hypertension; Male; Nifedipine; Nisoldipine; Pyridines; Rats; Rats, Inbred Strains; Renin | 1983 |
[Antianginal effect of calcium antagonists, using nisoldipine as an example].
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Electrocardiography; Exercise Test; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nisoldipine | 1984 |
Nisoldipine-induced relaxation in intact and skinned smooth muscles of rabbit coronary arteries.
Topics: Acetylcholine; Animals; Caffeine; Calcium; Contractile Proteins; Coronary Vessels; Drug Interactions; Electrophysiology; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Nifedipine; Nisoldipine; Potassium; Rabbits; Tetrodotoxin; Vasodilator Agents | 1984 |
Voltage clamp comparison of the organic calcium channel blockers D-600 and nisoldipine.
Topics: Animals; Anura; Atrial Function; Calcium Channel Blockers; Electrophysiology; Gallopamil; Heart Atria; In Vitro Techniques; Kinetics; Nifedipine; Nisoldipine; Verapamil | 1984 |
Direct visualization of the coronary microcirculation for pharmacologic and physiologic studies.
Topics: Animals; Calcium Channel Blockers; Capillary Permeability; Capillary Resistance; Coronary Circulation; Fluorescein-5-isothiocyanate; Fluoresceins; Heart Arrest, Induced; Histamine; Male; Microcirculation; Microscopy, Fluorescence; Nifedipine; Nisoldipine; Perfusion; Rats; Rats, Inbred Strains; Serum Albumin, Bovine | 1984 |
[Nisoldipine, a new calcium antagonist: its effect on systolic function and relaxation in the dog].
Topics: Animals; Calcium Channel Blockers; Cardiac Output; Cardiac Volume; Dogs; Heart Ventricles; Hemodynamics; Myocardial Contraction; Nifedipine; Nisoldipine; Systole | 1984 |
Effects of nicardipine and nisoldipine on myocardial metabolism, coronary blood flow and oxygen supply in angina pectoris.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Coronary Circulation; Hemodynamics; Humans; Lactates; Male; Middle Aged; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Oxygen Consumption | 1984 |
Energy conservation by nisoldipine in ischaemic heart.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Energy Metabolism; Heart; Male; Nifedipine; Nisoldipine; Purines; Rats; Rats, Inbred Strains | 1984 |
Calcium antagonists and stimulus-secretion coupling of aldosterone.
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Calcium; Calcium Channel Blockers; Nifedipine; Nisoldipine; Potassium; Sheep; Sodium; Transplantation, Autologous; Verapamil | 1984 |
45Ca2+ uptake into rat whole brain synaptosomes unaltered by dihydropyridine calcium antagonists.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Male; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Potassium Chloride; Rats; Rats, Inbred Strains; Synaptosomes | 1983 |
Pharmacologic inhibition of cerebral vasospasm in ischemia, hallucinogen ingestion, and hypomagnesemia: barbiturates, calcium antagonists, and magnesium.
Topics: Animals; Barbiturates; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Magnesium; Metabolic Diseases; Microcirculation; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Phencyclidine; Rats; Verapamil; Water Supply | 1983 |
The influence of nisoldipine--a "calcium entry blocker" on drug induced stereotyped behavior in rats.
Topics: Age Factors; Animals; Apomorphine; Arousal; Calcium Channel Blockers; Humans; Motor Activity; Nifedipine; Nisoldipine; Phencyclidine; Pyridines; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1983 |
Hemodynamic effects of nisoldipine in chronic congestive heart failure.
Topics: Adult; Calcium Channel Blockers; Heart Failure; Hemodynamics; Humans; Middle Aged; Nifedipine; Nisoldipine; Physical Exertion; Pyridines | 1983 |
Potassium stimulation of aldosterone secretion in vivo is reversed by nisoldipine, a calcium transport antagonist.
Topics: Adrenal Glands; Aldosterone; Animals; Calcium Channel Blockers; Female; Hydrocortisone; Kinetics; Nifedipine; Nisoldipine; Potassium Chloride; Sheep | 1984 |
Is nisoldipine capable of reducing left ventricular preload?
Topics: Animals; Blood Pressure; Cardiac Output; Heart; Heart Rate; Nifedipine; Nisoldipine; Stroke Volume; Swine; Vascular Resistance | 1984 |
Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: alterations in baroreflex sensitivity.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dogs; Female; Heart Rate; Hydralazine; Male; Nifedipine; Nisoldipine; Nitrendipine; Pressoreceptors | 1984 |
[Effect of the calcium antagonist nisoldipine on electrophysiologic parameters in the human].
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Electrocardiography; Female; Heart Conduction System; Heart Ventricles; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Pyridines; Sinoatrial Node | 1983 |
Comparative electrophysiologic and coronary hemodynamic effects of diltiazem, nisoldipine and verapamil on myocardial tissue.
Topics: Animals; Benzazepines; Bundle of His; Calcium Channel Blockers; Culture Techniques; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Atria; Heart Conduction System; Hemodynamics; Humans; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Pyridines; Verapamil | 1982 |
Nisoldipine: a new, more selective calcium current blocker in cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Cattle; Evoked Potentials; Gallopamil; Heart; Heart Conduction System; Nifedipine; Nisoldipine; Purkinje Fibers; Pyridines | 1982 |
Nisoldipine (BAY K 5552), a new calcium antagonist. Antihypertensive effect in conscious, unrestrained renal hypertensive dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dogs; Female; Heart Rate; Hypertension, Renal; Male; Nifedipine; Nisoldipine; Pyridines; Vasodilator Agents | 1982 |
Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4-dihydro-2,6-dimethyl-4(2-nitrophenyl)-3,5-pyridinedicarboxylate (Nisoldipine, Bay k 5552).
Topics: Animals; Blood Coagulation; Calcium; Cats; Chemical Phenomena; Chemistry; Diuresis; Dogs; Female; Guinea Pigs; Hemodynamics; Hypertension, Renovascular; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Nisoldipine; Norepinephrine; Potassium; Pyridines; Rabbits; Rats | 1980 |
Hemodynamic effects of the new vasodilator drug Bay k 5552 in man.
Topics: Adult; Blood Pressure; Calcium; Cardiac Output; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Pyridines; Vasodilator Agents | 1980 |
Blood flow in normal and acutely ischemic myocardium after verapamil, diltiazem and nisoldipine (Bay k 5552), a new dihydropyridine calcium antagonist.
Topics: Animals; Benzazepines; Calcium; Coronary Circulation; Coronary Disease; Diltiazem; Dogs; Female; Hemodynamics; Male; Nifedipine; Nisoldipine; Pyridines; Verapamil | 1981 |
The effect of diltiazem and nisoldipine on spontaneously active human atrial tissue.
Topics: Atrial Function; Benzazepines; Diltiazem; Electrophysiology; Heart; Humans; Membrane Potentials; Microelectrodes; Nifedipine; Nisoldipine; Pyridines; Tetrodotoxin | 1981 |
Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Disease; Heart Ventricles; Male; Nifedipine; Nisoldipine; Pyridines; Rats; Rats, Inbred Strains | 1981 |
Calcium antagonists prevent early post-infarction ventricular fibrillation.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Hemodynamics; Male; Myocardial Infarction; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains; Time Factors; Ventricular Fibrillation | 1981 |
Hemodynamic and antiischemic effects of nifedipine, lacidipine, and nisoldipine in rat isolated working heart.
Topics: Animals; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Dihydropyridines; Dose-Response Relationship, Drug; Heart; Hemodynamics; In Vitro Techniques; Male; Mice; Myocardial Ischemia; Nifedipine; Nisoldipine; Rats; Rats, Wistar; Ventricular Function, Left | 1993 |
Use of dextran-primed extracorporeal circuit in the canine model for venous return: with special references to the effects of two dihydropyridine-type Ca2+ channel blockers.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dextrans; Dihydropyridines; Dogs; Extracorporeal Circulation; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Nitroglycerin; Norepinephrine | 1995 |
The importance of calcium-related effects on energetics at hypothermia: effects of membrane-channel antagonists on energy metabolism of rat liver.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Chlorpromazine; Cryopreservation; Energy Metabolism; In Vitro Techniques; Ion Channels; Ion Transport; Liver; Male; Nifedipine; Nisoldipine; Organ Preservation; Prenylamine; Rats; Rats, Sprague-Dawley; Verapamil | 1995 |
In vitro effects of nifedipine, nisoldipine, and lacidipine on rat isolated coronary small arteries.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Potassium Chloride; Rats; Rats, Wistar; Serotonin Antagonists; Software; Vasoconstriction | 1993 |
Interaction between dihydropyridine calcium antagonists and morphine on the brain biogenic amines.
Topics: Animals; Biogenic Amines; Brain; Calcium Channel Blockers; Dopamine; Drug Interactions; Male; Morphine; Nifedipine; Nimodipine; Nisoldipine; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin | 1994 |
Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Dihydropyridines; Electric Conductivity; Female; Ion Channel Gating; Kinetics; Macromolecular Substances; Myocardium; Nifedipine; Nisoldipine; Oocytes; Structure-Activity Relationship; Xenopus laevis | 1995 |
Therapeutic approaches to the control of coronary atherosclerosis.
Topics: Animals; Aorta; Calcium; Cholesterol; Cholesterol, Dietary; Coronary Artery Disease; Diet, Atherogenic; Male; Nifedipine; Nisoldipine; Rabbits | 1994 |
Absence of antioxidant effects of nifedipine and diltiazem on myocardial membrane lipid peroxidation in contrast with those of nisoldipine and propranolol.
Topics: Animals; Antioxidants; Diltiazem; Fumarates; Heart; In Vitro Techniques; Lipid Peroxidation; Male; Myocardium; Nifedipine; Nisoldipine; Oxidation-Reduction; Oxygen; Propranolol; Rats; Rats, Sprague-Dawley | 1994 |
[Comparison of the negative inotropic properties of nifedipine and nisoldipine using isovolumetric contractile parameters of the rat in vivo].
Topics: Animals; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Myocardial Contraction; Nifedipine; Nisoldipine; Rats; Rats, Wistar; Ventricular Function, Left | 1994 |
Effects of calcium- and ETA-receptor antagonists on endothelin-induced vasoconstriction and levels of endothelin in the human internal mammary artery.
Topics: Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Humans; In Vitro Techniques; Isradipine; Mammary Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrendipine; Peptides, Cyclic; Radioimmunoassay; Vasoconstriction | 1994 |
Cardiac structural remodelling after treatment of spontaneously hypertensive rats with nifedipine or nisoldipine.
Topics: Animals; Cell Size; Fibrosis; Heart; Hypertension; Male; Myocardium; Nifedipine; Nisoldipine; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors | 1993 |
Comparison among the effects of nifedipine, nimodipine and nisoldipine on the brain biogenic amines of normal or haloperidol treated rats.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Calcium Channel Blockers; Dopamine; Haloperidol; Male; Nifedipine; Nimodipine; Nisoldipine; Rats; Rats, Sprague-Dawley; Serotonin | 1993 |
Improvement of ischemic myocardial dysfunction by nisoldipine in relation to its coronary vasodilating action.
Topics: Animals; Blood Pressure; Coronary Circulation; Diltiazem; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Nifedipine; Nisoldipine; Perfusion; Rabbits; Vasodilator Agents | 1993 |
Effects of manidipine and other calcium antagonists on rat renal arcuate arteries.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrobenzenes; Piperazines; Potassium Chloride; Rats; Rats, Wistar; Renal Artery; Serotonin | 1993 |
Attenuation of myocardial reperfusion injury by reducing intracellular calcium overloading with dihydropyridines.
Topics: Animals; Calcium; Coronary Circulation; Creatine Kinase; Dihydropyridines; Free Radical Scavengers; Lipid Peroxidation; Male; Myocardial Reperfusion Injury; Myocardium; Nifedipine; Nimodipine; Nisoldipine; Perfusion; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 1993 |
Pharmacological profile of semotiadil fumarate, a novel calcium antagonist, in rat experimental angina model.
Topics: Acetylcholine; Angina Pectoris; Animals; Arginine Vasopressin; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Disease Models, Animal; Electrocardiography; Male; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Thiazoles; Vasoconstrictor Agents | 1995 |
Inhibition of nisoldipine on bovine mesenteric arteries and veins and on human peripheral veins.
Topics: Animals; Cattle; Humans; In Vitro Techniques; Mesenteric Arteries; Mesenteric Veins; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitroglycerin; Potassium; Potassium Chloride; Regional Blood Flow; Saphenous Vein | 1995 |
Antioxidant properties of dihydropyridines in isolated rat hearts.
Topics: Animals; Antioxidants; Calcium Channel Blockers; Heart; Heart Diseases; Hydrogen Peroxide; In Vitro Techniques; Male; Myocardial Contraction; Nifedipine; Nisoldipine; Perfusion; Rats; Rats, Sprague-Dawley; Stereoisomerism; Time Factors | 1996 |
Heart period variability in patients with variant angina.
Topics: Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Electrocardiography, Ambulatory; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Sympathetic Nervous System | 1996 |
[Effect of efonidipine hydrochloride on myocardial oxygen balance in anesthetized dogs].
Topics: Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart Rate; Male; Myocardium; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Oxygen Consumption; Thoracotomy | 1996 |
[Effect of efonidipine hydrochloride (NZ-105), a dihydropyridine derivative with calcium antagonistic action, on myocardial oxygen tension in anesthetized dogs].
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Myocardium; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Oxygen Consumption; Partial Pressure | 1996 |
Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Felodipine; Fumarates; Heart; Iron; Lipid Peroxidation; Male; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Cardioprotective and hypolipidemic effects of nisoldipine in the JCR:LA-cp rat.
Topics: Animals; Blood Glucose; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Female; Hypolipidemic Agents; Lipids; Male; Microscopy, Electron, Scanning; Myocardial Contraction; Myocardium; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains; Sex Characteristics; Time Factors | 1997 |
Inhibitory effects of efonidipine hydrochloride on contraction induced by several vasoconstrictors in porcine coronary artery: comparison with effects of nifedipine and nisoldipine.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding, Competitive; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Endothelin-1; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Potassium; Prostaglandin Endoperoxides, Synthetic; Serotonin; Swine; Thromboxane A2; Vasoconstrictor Agents | 1997 |
Comparison of the effects of nifedipine and nisoldipine on coronary vasoconstriction in the Langendorff-perfused rat heart.
Topics: Animals; Blood Pressure; Coronary Circulation; Endothelin-1; Heart; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilator Agents | 2000 |
Nifedipine and nisoldipine modulate membrane potential of vascular endothelium via a myo-endothelial pathway.
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels, L-Type; Endothelium, Vascular; Male; Membrane Potentials; Nifedipine; Nisoldipine; Rabbits; Rats | 2000 |
Selectivity of blocking of low- versus high-voltage activated calcium currents by the dihydropyridine derivatives Bay E5759 and Bay A4339 in neuroblastoma--glioma NG 108-15 cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Electrophysiology; Hybrid Cells; Mibefradil; Mice; Nifedipine; Nisoldipine; Rats; Tumor Cells, Cultured | 2001 |
Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cattle; Cell Survival; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Lipid Peroxidation; Molsidomine; Nicardipine; Nifedipine; Nisoldipine; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Thiobarbituric Acid Reactive Substances | 2002 |
Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders.
Topics: Adult; Aged; Analysis of Variance; Anticonvulsants; Calcium Channel Blockers; Cell Culture Techniques; Cell Division; Collagen; Diltiazem; DNA; ErbB Receptors; Female; Fibroblasts; Flow Cytometry; Gingiva; Gingival Overgrowth; Humans; Male; Middle Aged; Nicardipine; Nifedipine; Nisoldipine; Phenytoin; Radiopharmaceuticals; Statistics as Topic; Tritium; Verapamil | 2001 |
[Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine].
Topics: Adult; Calcium Channel Blockers; Citrus; Flavanones; Flavonoids; Food-Drug Interactions; Humans; Male; Nifedipine; Nisoldipine | 2002 |
Anti-arrhythmic and hemodynamic effects of oxy nifedipine, oxy nimodipine, oxy nitrendipine and oxy nisoldipine.
Topics: Administration, Intravenous; Administration, Oral; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Dihydropyridines; Heart; Hemodynamics; Male; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2012 |