nifedipine has been researched along with nilvadipine in 229 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (21.40) | 18.7374 |
| 1990's | 93 (40.61) | 18.2507 |
| 2000's | 61 (26.64) | 29.6817 |
| 2010's | 24 (10.48) | 24.3611 |
| 2020's | 2 (0.87) | 2.80 |
| Authors | Studies |
|---|---|
| Aisaka, K; Cho, H; Hamaguchi, M; Hayashimatsu, M; Hidaka, T; Mizuno, A; Ohnaka, Y; Shima, K; Takeuchi, Y; Ueda, M | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Horinouchi, M; Komada, F; Nishiguchi, K; Ohmoto, N; Ohnishi, N; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y; Yokoyama, T | 1 |
| Sun, H | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Arakawa, H; Hirosumi, J; Mutoh, S; Yamaguchi, I | 1 |
| Honerjäger, P; Seibel, K | 1 |
| Huber, HJ; Stanislaus, F; von Nieciecki, A | 1 |
| Huber, HJ; Kuchlbauer, R; Lossnitzer, K; Quitzdorff, G | 1 |
| Keck, M | 1 |
| Faust, G | 2 |
| Fritschka, E | 1 |
| Albert, FW; Berger, HH | 1 |
| Keck, M; Quitzdorff, G | 1 |
| Furuichi, Y; Kohsaka, M; Mori, J; Satoh, H; Takakura, S | 2 |
| Fujiwara, T; Kohsaka, M; Mori, J; Satoh, H; Sogabe, K; Takakura, S; Tokuma, Y; Totsuka, Z | 1 |
| Bokura, K; Kobayashi, S; Murao, M; Okada, K; Suyama, N; Tsunematsu, T; Yamaguchi, S | 1 |
| Pollack, KP | 1 |
| Kawano, N; Ono, J; Takaki, R; Yarimizu, K | 1 |
| Haramoto, T; Hironaka, K; Kumagai, I; Makino, H; Nishii, M; Ota, Z; Shikata, K; Takahashi, M; Yamasaki, Y | 1 |
| Kawai, K; Murayama, Y; Suzuki, S; Watanabe, Y; Yamashita, K | 1 |
| Fujishima, M; Ito, Y; Kikuchi, M; Kobayashi, K; Takata, Y; Tsukashima, A; Ueno, M; Yoshizumi, T | 1 |
| Oyanagui, Y; Sato, S | 1 |
| Aoyagi, T; Iizuka, M; Ikenouchi, H; Matsui, H; Mochizuki, T; Momomura, S; Sato, H; Serizawa, T; Sugimoto, T | 1 |
| Handa, J; Mori, J; Satoh, H; Shiino, A; Susumu, T; Takakura, S | 1 |
| Abe, I; Fujishima, M; Kobayashi, K; Matsumura, K; Nakao, Y; Tominaga, M; Tsuchihashi, T; Tsukashima, A | 1 |
| Ichihashi, M; Okumura, K; Satoh, Y | 1 |
| Handa, J; Inubushi, T; Kido, C; Matsuda, M; Morikawa, S; Shiino, A; Susumu, T | 1 |
| Fukasawa, H; Kawamura, S; Shirasawa, M; Yasui, N | 2 |
| Handa, J; Matsuda, M; Shiino, A; Susumu, T | 1 |
| Furui, H; Furumichi, T; Saito, H; Yamada, Y; Yamauchi, K; Yokota, M | 1 |
| Fukuuchi, Y; Gotoh, F; Isozumi, K; Izumi, Y | 1 |
| Chen, CF; DeQuattro, V; Douglas, J; Saunders, E; Singh, S; Svetkey, LP; Vlachkis, ND; Weir, MR; Wiedl, SC; Woodward, DL | 1 |
| Abe, K; Kanazawa, M; Kohzuki, M; Kudo, K; Omata, K; Sato, M; Takeuchi, K; Tsunoda, K; Yasujima, M; Yoshida, K | 2 |
| Barone, FC; Ormsbee, HS; Wasserman, MA; White, RF | 1 |
| Furuta, T | 1 |
| Kishino, J; Takemura, M; Wada, H; Yamatodani, A | 1 |
| Koibuchi, Y; Miura, S; Ohtsuka, M; Ono, T; Sakai, S; Shibayama, F | 1 |
| Noguchi, H; Sekiguchi, M; Terashita, S; Tokuma, Y | 1 |
| Ishida, N; Mitsui, Y; Saida, K; Tomoi, M; Tsujioka, K | 1 |
| Fujiwara, T; Hashimoto, T; Niwa, T; Noguchi, H; Tokuma, Y | 1 |
| Hayashi, H; Iwase, M; Kamihara, S; Miyahara, T; Ozawa, T; Saito, H; Sugiyama, S; Yokota, M | 1 |
| Koibuchi, Y; Matsuo, M; Ohtsuka, M; Ono, T; Shibayama, F; Tomoi, M | 1 |
| Hardman, JM; Lee, HC; Lum, BK | 1 |
| Hayashi, H; Iwase, M; Kamihara, S; Koide, M; Miyahara, T; Ozawa, T; Sugiyama, S; Yokota, M | 1 |
| Hagihara, H; Mutoh, S; Nomoto, A; Yamaguchi, I | 1 |
| Kuwaki, T; Nishimura, T; Ono, T; Satoh, H; Shibayama, F; Yamashita, T | 1 |
| Lee, HC; Lum, BK | 1 |
| Jim, KF; Macia, RA; Matthews, WD | 1 |
| Kishida, H; Suzuki, K; Toyama, S; Yanaga, T | 1 |
| Fujiwara, T; Horiai, H; Koibuchi, Y; Maeda, K; Motoyama, I; Ohtsuka, M; Ono, T; Ozaki, T; Sakai, S; Tsujioka, K | 1 |
| Ishii, A; Nakamizo, N; Nishida, K; Oka, T | 1 |
| Cheung, WK; Desjardins, RE; Hibberd, M; Pearse, S; Shin, K; Silber, BM; Woodward, DL; Yacobi, A | 1 |
| Cheung, WK; Desjardins, RE; Graveline, JF; Sia, LL; Silber, BM; Woodward, DL; Yacobi, A | 1 |
| Mutoh, S; Nomoto, A; Sekiguchi, C; Yamaguchi, I | 1 |
| Hashimoto, N; Hattori, N; Nakamura, S; Ohta, H; Satoh, S; Takabatake, T; Yamada, Y; Yamamoto, Y | 1 |
| Niwa, T; Noguchi, H; Sekiguchi, M; Tokuma, Y | 1 |
| Niwa, T; Noguchi, H; Tokuma, Y | 2 |
| Kuwahara, N; Noguchi, H; Shishido, A; Terakawa, M; Tokuma, Y | 1 |
| Kato, R; Nakagawa, K; Niwa, T; Noguchi, H; Tokuma, Y; Yamazoe, Y | 1 |
| Fujiwara, T; Noguchi, H; Tokuma, Y | 4 |
| Fujiwara, T; Noguchi, H; Okumura, K; Shiokawa, Y; Terashita, S; Tokuma, Y | 1 |
| Fukuchi, S; Hashimoto, S; Kunii, N; Mizuno, K; Niimura, S; Tani, M; Watari, H; Yabe, R | 1 |
| Fujiwara, T; Noguchi, H; Sekiguchi, M; Tokuma, Y | 1 |
| Aoki, H; Hirosumi, J; Mutoh, S; Nomoto, A; Sekiguchi, C; Yamaguchi, I | 1 |
| Kamihara, S; Koide, M; Miyahara, T; Noda, S; Sotobata, I; Tsunekawa, A; Yokota, M | 1 |
| Noguchi, H; Shishido, A; Terakawa, M; Tokuma, Y | 1 |
| Noguchi, H; Shishido, A; Terakawa, M; Tokuma, Y; Yasuda, K | 1 |
| Molyvdas, PA; Sperelakis, N | 1 |
| Bkaily, G; Molyvdas, PA; Ousterhout, J; Sperelakis, N | 1 |
| Koda, S; Miyamae, A; Morimoto, Y | 1 |
| Brooks, HL; Gross, GJ; Warltier, DC; Zyvoloski, MG | 3 |
| Gross, GJ; Hardman, HF; Warltier, DC | 1 |
| Gross, GJ; Warltier, DC | 1 |
| Satake, N; Shibata, S; Takagi, T | 1 |
| Izawa, T; Izumi, H; Jinno, Y; Kaneta, S; Ogawa, N; Okada, Y; Tanaka, Y | 1 |
| Honda, M; Kuramochi, T; Morioka, S; Tanaka, K | 1 |
| Kawamura, S; Yasui, N | 1 |
| Fujihira, S; Ishida, H; Mine, Y; Mitamura, T; Noguchi, H; Ohara, K; Yamada, A | 1 |
| Ayaori, M; Hosoai, H; Ishikawa, T; Nakamura, H; Nishiwaki, M; Suzukawa, M; Yoshida, H | 1 |
| Shimamoto, H; Shimamoto, Y | 1 |
| Deguchi, S; Hata, T; Sawamoto, T; Terashita, S; Tokuma, Y | 1 |
| Brogden, RN; McTavish, D | 1 |
| Hayashi, T; Hoki, N; Hori, M; Kamada, T; Karita, M; Kodama, K; Naka, M; Nanto, S; Sato, H; Yamada, Y | 1 |
| Hashimoto, M; Honda, M; Ishikawa, S; Kuramochi, T; Mansoor, AM; Masumura, S; Morioka, S; Tanaka, K | 1 |
| Hata, T; Sawamoto, T; Terashita, S; Tokuma, Y; Tozuka, Z | 1 |
| Rosenthal, J | 1 |
| Fukasawa, H; Kawamura, S; Li, Y; Shirasawa, M; Yasui, N | 3 |
| Enomoto, K; Hashimoto, M; Honda, M; Kuramochi, T; Mansoor, AM; Morioka, S; Tanaka, K | 1 |
| Okumura, K; Satoh, Y; Shiokawa, Y | 1 |
| Schmitt, W; Vollmuth, M | 1 |
| Sanada, H | 1 |
| Furuichi, Y; Mori, J; Ogawa, T; Satoh, H; Takakura, S; Yamamoto, T | 1 |
| Ishibashi, K; Ishida, T; Ishida-Kainouchi, M; Kajiyama, G; Kanbe, M; Matsuura, H; Okura, Y; Oshima, T; Ozono, R; Watanabe, M | 1 |
| Akiyama, Y; Enomoto, K; Kawahara, M; Maeno, T; Moritake, K; Nagao, S; Yamasaki, T | 1 |
| Iwasaki, K; Kato, R; Nozaki, K; Shiraga, T; Takanaka, A; Tamura, T; Yamazoe, Y | 1 |
| Zieleniewski, W | 1 |
| Asai, Y; Kohno, Y; Nakashima, M; Uematsu, T; Umemura, K | 1 |
| Bannai, C; Kawakami, Y; Mizutani, M; Okuda, Y; Sone, H; Yamashita, K | 1 |
| Inoue, H; Oh-hashi, S; Takata, M; Tomoda, F; Ueno, H; Yasumoto, K | 1 |
| Fujii, K; Maruyama, S; Miyasaka, Y; Nagai, S; Tanaka, R | 1 |
| Asai, M; Ashikari, I; Kanba, S; Ohnishi, K; Yagi, G; Yamada, K | 1 |
| Kikuchi, K; Sugawara, H; Tobise, K | 1 |
| Morokoshi, N; Nakagawa, T; Nakao, C; Sawada, T; Shibukawa, A; Terakita, A | 1 |
| Akaike, N; Ishibashi, H; Rhee, JS | 1 |
| Burkardt, I; Hoffmann, A; Kraul, H | 1 |
| Araie, M; Muta, K | 1 |
| Asai, M; Ashikari, I; Kanba, S; Onishi, K; Yagi, G; Yamada, K | 1 |
| Endo, M; Izawa, T; Izumi, H; Jinno, Y; Kawahara, J; Takeuchi, A | 1 |
| Izumi, Y; Kitadai, M; Satoh, K; Takahashi, T; Tsuda, Y | 1 |
| Inoue, H; Oh-hashi, S; Takata, M; Tomita, S; Ueno, H; Yasumoto, K | 1 |
| Fukuda, K; Funai, H; Hano, T; Iseki, Y; Kasamatsu, K; Kuse, S; Nakamura, N; Nishio, I; Ohta, A; Satani, O; Ueno, C; Ueno, Y; Yoshikawa, H | 1 |
| Hayasaka, S; Hiraki, S; Zhang, XY | 1 |
| Abe, I; Fujishima, M; Hasuo, Y; Nishino, Y; Onaka, U; Setoguchi, M | 1 |
| Cioffi, GA | 1 |
| Kawakami, H; Kitazawa, Y; Niwa, Y; Yamamoto, T | 1 |
| Imai, Y; Ohkubo, T; Omae, T; Sekino, M | 1 |
| Akaike, N; Ishibashi, H; Murai, Y | 1 |
| Harada, K; Kawahara, J; Kusaka, M; Okada, Y; Tokiwa, T; Uzumaki, H | 1 |
| Fujiwara, K; Hayashi, K; Nagahama, T; Ozawa, Y; Saruta, T; Wakino, S | 1 |
| Izawa, T; Kashiwabara, T; Kawahara, J; Ogawa, N; Okada, Y | 1 |
| Adachi, C; Demura, H; Demura, R; Imaki, T; Mishina, N; Naruse, K; Naruse, M; Seki, T; Tanabe, A; Yoshimoto, T | 1 |
| Hayasaka, S; Hiraki, S; Kadoi, C; Ohtani, O | 1 |
| Araie, M; Nagahara, M; Sugiyama, T; Tamaki, Y; Tomita, K | 1 |
| Higuchi, H; Hishikawa, Y; Shimizu, T; Takahashi, H; Yoshimoto, M | 1 |
| Araie, M; Azuma, I; Hara, H; Iwakura, Y; Sakai, T; Shimazawa, M; Sugiyama, T; Watari, M | 1 |
| Hattori, Y; Irie, M; Takeda, S; Ueshiba, H | 1 |
| Fukuhara, S; Kagawa, H; Nagahama, M; Nomura, S; Ozaki, Y | 1 |
| Matsuda, Y; Tsukuda, E | 1 |
| Askal, HF; El Gizawy, S; El Kommos, ME; Kuroda, Y; Mohamed, NA; Nakagawa, T; Shibukawa, A | 1 |
| Higuchi, T; Murata, T; Oshima, A; Suzuki, R | 1 |
| Inouye, M; Mio, T; Sumino, K | 1 |
| Harris, A; Kagemann, L; Kawakami, H; Kitazawa, Y; Niwa, Y; Yamamoto, T | 1 |
| Arima, H; Hirayama, F; Honjo, M; Okimoto, K; Uekama, K | 1 |
| Hayashi, N; Kitazawa, Y; Niwa, Y; Shinohara, H; Tomita, G; Yamamoto, T | 1 |
| Kaneko, T; Kayama, N; Ogata, Y; Ueno, S | 1 |
| Frański, R; Mielcarek, J; Stobiecki, M | 1 |
| Mielcarek, J | 1 |
| Horiai, H; Ohtsuka, M; Oyanagui, Y | 1 |
| Hara, H; Sasaoka, M; Shimazawa, M; Sugiyama, T; Toriu, N | 1 |
| Abdine, H; Belal, F; Zoman, N | 1 |
| Belz, GG; Breithaupt-Grögler, K; Meurer-Witt, B; Ungethüm, W | 1 |
| Maeda, A; Maeda, T; Maruyama, I; Nakazawa, M; Ogawa, K; Ohguro, H; Takano, Y | 1 |
| Cao, B; Kuroda, Y; Nakagawa, T; Shibukawa, A | 1 |
| Augustyniak, W; Mielcarek, J; Milewski, M; Szamburska, O | 1 |
| Tateishi, T; Yasui-Furukori, N | 1 |
| Echizen, H; Fukuda, J; Furuie, K; Hayashi, T; Saima, S; Yoshimoto, H | 1 |
| Dezawa, M; Maeda, T; Maruyama, I; Metoki, T; Nakazawa, M; Ohguro, H; Sawada, H; Takano, Y; Yamazaki, H | 1 |
| Kobayashi, M; Noda, A; Ogasawara, K; Ogawa, A; Yasuda, S; Yukawa, H | 1 |
| Kawasaki, A; Kusaka, S; Miki, A; Morimura, H; Otori, Y; Tano, Y | 1 |
| Fu, Q; Hagina, J; Kagawa, C; Kunimoto, KK; Sanbe, H | 1 |
| Danjo, K; Hirasawa, N; Ishise, S; Miyata, H | 3 |
| Ishikawa, F; Mamiya, K; Metoki, T; Miyagawa, Y; Nakazawa, M; Ohguro, H; Ohguro, I; Sato, M; Takano, Y; Yamazaki, H | 1 |
| Araie, M; Fukaya, Y; Hosokawa, T; Ishii, K; Takayama, J; Tamaki, Y; Tomidokoro, A | 1 |
| Al-Khatib, IH; Egashira, N; Egawa, T; Fujiwara, M; Irie, K; Ishibashi, D; Iwasaki, K; Kobayashi, H; Mishima, K | 1 |
| Ishikawa, F; Mamiya, K; Nakazawa, M; Ohguro, H; Ohguro, I; Takano, Y; Yamazaki, H | 1 |
| Dezawa, M; Ishikawa, F; Ishikawa, H; Mamiya, K; Metoki, T; Nakazawa, M; Ohguro, H; Ohguro, I; Takano, Y; Yamazaki, H | 1 |
| Crawford, F; Crescentini, R; Humphrey, J; Mullan, M; Paris, D; Patel, N; Quadros, A | 1 |
| Hirasawa, N; Ishise, S; Miyata, H | 1 |
| Hashimoto, T; Kagayama, A; Niwa, T; Shiraga, T | 1 |
| Enomoto, A; Konda, T; Kondo, N; Takahara, A | 1 |
| Imai, E; Moriyama, T; Oka, K; Ueda, H | 1 |
| Asai, M; Iwasaki, Y; Kambayashi, M; Nakashima, N; Nigawara, T; Oiso, Y; Yoshida, M | 1 |
| Araie, M; Takayama, J; Tamaki, Y; Tomidokoro, A | 1 |
| Haginaka, J; Hoshina, K; Sambe, H | 1 |
| Araki, T; Himeda, T; Kanbara, S; Kato, H; Oki, C | 1 |
| Leonetti, G | 1 |
| Higaki, K; Ibuki, R; Imai, K; Kimura, T; Ohike, A; Okimoto, K; Tanaka, N; Tokunaga, Y; Ueda, S | 1 |
| Higaki, K; Ibuki, R; Imai, K; Kimura, T; Okimoto, K; Tanaka, N; Tokunaga, Y; Ueda, S | 1 |
| Horii, M; Imagawa, K; Iwama, H; Kawata, H; Nakajima, T; Naya, N; Okayama, S; Saito, Y; Somekawa, S; Uemura, S | 1 |
| Aso, Y; Kawanishi, T; Miyazaki, T; Yoshioka, S | 1 |
| Nakatani, Y; Sasaki, T; Sugiyama, K | 1 |
| Abe, K; Hanyu, H; Hirao, K; Iwamoto, T; Koizumi, K; Shimizu, S | 1 |
| Egashira, N; Fujiwara, M; Hatip-Al-Khatib, I; Iwasaki, K; Mishima, K; Takagaki, Y; Yoshimitsu, Y | 1 |
| Shinohara, Y | 1 |
| Fukuuchi, Y; Hirai, S; Okudera, T; Shinohara, Y; Terashi, A; Tohgi, H; Yamaguchi, T | 1 |
| Mizukoshi, S; Nakazawa, M; Takeuchi, K | 1 |
| Hanyu, H; Hirao, K; Iwamoto, T; Kiuchi, A; Sato, T; Shimizu, S | 1 |
| Araki, N; Imabayashi, E; Kuji, I; Matsuda, H; Ohkubo, T; Shimazu, K | 1 |
| Ohguro, H | 1 |
| Futagami, A; Haginaka, J | 1 |
| Hino, E; Kawabe, Y; Nakamura, H; Suzuki, S | 1 |
| Dohmen, W | 1 |
| Araie, M; Hasegawa, T; Koseki, N; Nagahara, M; Tamaki, Y; Tomidokoro, A; Yamamoto, S | 1 |
| Akai, T; Hanyu, H; Iwamoto, T; Sakurai, H; Sato, T; Takasaki, A | 1 |
| Oguro, H; Saito, Y | 1 |
| Crawford, JJ; MacFaul, PA; Morley, AD | 1 |
| Maeda, H; Obata, K; Ogawa, Y; Sakai, K; Yoshimori, T | 1 |
| Maeda, H; Obata, K; Sakai, K; Yoshimori, T | 1 |
| Ito, T; Metoki, T; Miyagawa, Y; Nakazawa, M; Ohguro, H; Takeuchi, K | 1 |
| Ishida, S; Koto, T; Nagai, N; Oike, Y | 1 |
| Ishii, K; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Allocca, M; Auricchio, A; Di Vicino, U; Iodice, C; Manfredi, A | 1 |
| Araie, M | 1 |
| Abdullah, L; Crawford, F; Kennelly, S; Kenny, RA; Lawlor, B; Luis, CA; Mathura, V; Mouzon, B; Mullan, M | 1 |
| Abdullah, L; Crawford, F; Kennelly, SP; Kenny, RA; Lawlor, BA; Mathura, V; Mullan, M; Paris, D; Parish, J | 1 |
| Hayashi, M; Sakai, T; Sako, K | 1 |
| Kojima, Y; Maeda, H; Ogawa, Y; Ohta, T; Shiraki, K; Takano, R | 1 |
| Araie, M; Ishii, K; Mayama, C; Ota, T; Tomidokoro, A | 1 |
| Ito, T; Kudo, T; Metoki, T; Nakazawa, M; Ohguro, H; Suzuki, Y | 1 |
| Ishii, K; Kuroki, T; Mori, A; Nakahara, T; Sakamoto, K | 1 |
| Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K | 1 |
| Adams, J; Banzi, R; Borjesson, A; Breuilh, L; Coen, R; Crawford, F; Cregg, F; Daly, L; Gaynor, S; Howard, R; Kalman, J; Kennelly, S; Kenny, RA; Lawlor, B; Lucca, U; Molloy, W; Mullan, M; Murphy, C; O'Dwyer, S; Olde Rikkert, M; Pasquier, F; Riepe, M; Segurado, R; Tsolaki, M; Wallin, A; Walsh, C | 1 |
| Ait-Ghezala, G; Bachmeier, C; Beaulieu-Abdelahad, D; Crawford, F; Jin, C; Laco, G; Lin, Y; Mullan, M; Paris, D | 1 |
| Abdullah, L; Adams, J; Banzi, R; Borjesson-Hanson, A; Breuilh, L; Coen, R; Crawford, F; Cregg, F; Daly, L; de Jong, D; Gaynor, S; Howard, R; Kalman, J; Kennelly, S; Kenny, RA; Lawlor, B; Lucca, U; Meulenbroek, O; Molloy, W; Mullan, M; O'Dwyer, S; Olde Rikkert, M; Pasquier, F; Riepe, M; Segurado, R; Tsolaki, M; van Spijker, G; Wallin, A; Walsh, C | 1 |
| Adams, J; Aisen, P; Anastasios, O; Banzi, R; Börjesson-Hanson, A; Breuilh, L; Calais, G; Coen, R; Crawford, F; Cregg, F; Daly, L; de la Sayette, V; Dereeper, O; Devendeville, A; Franceschi, M; Frisoni, G; Gaynor, S; Hendrix, S; Howard, R; Kálmán, J; Kennelly, S; Kenny, RA; Konsta, A; Lavenu, I; Lawlor, B; Lucca, U; Molloy, DW; Mullan, M; Nemni, R; Nenopoulou, S; Nobili, F; O'Dwyer, S; Olde Rikkert, MGM; Pakaski, M; Pasquier, F; Riepe, MW; Segurado, R; Sénéchal, O; Sheikhi, A; Taekema, DG; Tsolaki, M; Tsolaki-Tagaraki, F; Verhey, FR; Walsh, C; Zanetti, O | 1 |
| Kestur, US; Mugheirbi, NA; Saboo, S; Taylor, LS; Zemlyanov, DY | 1 |
| Claassen, JAHR; de Heus, RAA; Donders, R; Lawlor, BA; Olde Rikkert, MGM; Santoso, AMM | 1 |
| Claassen, JAHR; de Heus, RAA; de Jong, DLK; Donders, R; Günther, M; Lawlor, BA; Olde Rikkert, MGM; Rijpma, A; van Osch, MJP | 1 |
| Claassen, JAHR; de Heus, RAA; Lawlor, BA; Olde Rikkert, MGM; Tully, PJ | 1 |
| Dyer, AH; Kennelly, SP; Lawlor, B; Murphy, C; Segurado, R | 1 |
| Browning, M; Crawford, F; Ferguson, S; Morin, A; Mouzon, B; Mullan, M; Paris, D; Stewart, W | 1 |
9 review(s) available for nifedipine and nilvadipine
| Article | Year |
|---|---|
Pharmacodynamics of nilvadipine, a new dihydropyridine-type calcium antagonist.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Heart; Heart Failure; Hemodynamics; Humans; Nifedipine; Vasodilation | 1992 |
Pharmacokinetics of nilvadipine.
Topics: Absorption; Antihypertensive Agents; Biological Availability; Calcium Channel Blockers; Half-Life; Humans; Kidney; Liver; Nifedipine | 1992 |
Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina.
Topics: Aging; Angina Pectoris; Animals; Antihypertensive Agents; Calcium Channel Blockers; Cerebrovascular Disorders; Hemodynamics; Humans; Hypertension; Nifedipine | 1995 |
Nilvadipine: profile of a new calcium antagonist. An overview.
Topics: Antihypertensive Agents; Biological Availability; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Heart; Humans; Hypertension; Lung; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Structure-Activity Relationship; Vasodilation | 1994 |
[PICA study--hypertension and asymptomatic cerebral infarction].
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Infarction; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine | 2006 |
[New drug therapy for retinal degeneration].
Topics: Animals; Calcium Channel Blockers; Dark Adaptation; Disease Models, Animal; Humans; Mice; Mutation; Nifedipine; Phosphorylation; Rats; Retinitis Pigmentosa; Rhodopsin | 2008 |
[Paraneoplastic retinopathy].
Topics: Antibodies, Neoplasm; Autoantibodies; Calcium Channel Blockers; HSC70 Heat-Shock Proteins; Humans; Neoplasms; Nifedipine; Paraneoplastic Syndromes, Nervous System; Prognosis; Recoverin; Retina; Retinal Diseases | 2008 |
[Cause of retinitis pigmentosa and new therapeutics under development].
Topics: Animals; c-Mer Tyrosine Kinase; Carrier Proteins; cis-trans-Isomerases; Cyclic Nucleotide Phosphodiesterases, Type 6; Disease Models, Animal; Drug Design; Eye Proteins; Genetic Therapy; Humans; Intercellular Signaling Peptides and Proteins; Intermediate Filament Proteins; Membrane Glycoproteins; Molecular Targeted Therapy; Mutation; Nerve Tissue Proteins; Nifedipine; Peripherins; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Retinitis Pigmentosa; Rhodopsin; Vitamin A | 2011 |
[Basic and clinical studies of pressure-independent damaging factors of open angle glaucoma].
Topics: Animals; Calcium Channel Blockers; Glaucoma, Open-Angle; Haplorhini; Humans; Intraocular Pressure; Mice; Nifedipine | 2011 |
46 trial(s) available for nifedipine and nilvadipine
| Article | Year |
|---|---|
24-hour blood pressure control after single daily doses of nivaldipine in patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Drug Administration Schedule; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1992 |
Comparison of the efficacy of nilvadipine and nitrendipine on circadian blood pressure.
Topics: Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine; Placebos | 1992 |
The tolerability of nilvadipine compared to nifedipine in patients with essential hypertension.
Topics: Alanine Transaminase; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Tolerance; Female; Heart Rate; Humans; Hypertension; Liver; Male; Middle Aged; Nifedipine | 1992 |
Comparisons of once-daily nilvadipine with enalapril and diuretic in patients with essential hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Drug Tolerance; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nifedipine; Triamterene | 1992 |
[Effect of nilvadipine on diurnal blood pressure profile. Use of a new calcium channel blocker in mild to intermediate hypertension].
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Single-Blind Method | 1992 |
Comparison of the effects of nilvadipine and captopril on glucose and lipid metabolism in NIDDM patients with hypertension.
Topics: Analysis of Variance; Apolipoprotein A-I; Apolipoprotein A-II; Apolipoproteins B; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Captopril; Cholesterol; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Heart Rate; Humans; Hypertension; Lipids; Male; Middle Aged; Nifedipine; Pulse | 1992 |
Evaluation of the clinical pharmacology of nilvadipine in patients with mild to moderate essential hypertension.
Topics: Blood Pressure; Double-Blind Method; Drug Evaluation; Heart Rate; Humans; Hypertension; Multicenter Studies as Topic; Nifedipine; Random Allocation; Time Factors | 1990 |
Effect of a new calcium antagonist, nilvadipine, on variant angina pectoris evaluated by 24-hour Holter electrocardiography.
Topics: Angina Pectoris, Variant; Calcium Channel Blockers; Clinical Trials as Topic; Drug Administration Schedule; Electrocardiography; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Nifedipine | 1988 |
Pharmacokinetics of nilvadipine after single oral doses in healthy volunteers.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Male; Nifedipine; Random Allocation | 1988 |
Importance of oral dosing rate on the hemodynamic and pharmacokinetic profile on nilvadipine.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Heart Rate; Hemodynamics; Humans; Male; Nifedipine | 1988 |
Nilvadipine increases cerebral blood flow in elderly hypertensives: comparison with nifedipine.
Topics: Aged; Aging; Antihypertensive Agents; Aorta; Cerebrovascular Circulation; Compliance; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Ultrasonography | 1995 |
[Nilvadipin for nifedipine induced calf edema. Results of a double blind randomized comparative study].
Topics: Aged; Blood Pressure; Body Weight; Calcium Channel Blockers; Double-Blind Method; Edema; Female; Heart Rate; Humans; Hypertension; Leg; Male; Middle Aged; Nifedipine; Treatment Outcome | 1994 |
Long-term clinical effect of nilvadipine in patients with chronic heart failure: a double-blind placebo-controlled study.
Topics: Calcium Channel Blockers; Double-Blind Method; Exercise Tolerance; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Time Factors | 1994 |
[Effect of nilvadipine on nifedipine-induced edema of the lower leg. Results of a double-blind randomized comparative study].
Topics: Aged; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1994 |
[A one year study of single administration of nilvadipine. Results of the effectiveness and long-term tolerance in hypertension].
Topics: Aged; Calcium Channel Blockers; Double-Blind Method; Female; Humans; Hypertension; Long-Term Care; Male; Middle Aged; Nifedipine | 1993 |
The effect of nilvadipine on bloodflow in the dorsal pedis artery in type 2 diabetic patients--a study using duplex Doppler ultrasonography.
Topics: Arteries; Blood Flow Velocity; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Female; Foot; Humans; Male; Middle Aged; Nifedipine; Ultrasonography, Doppler, Duplex | 1995 |
Time course of regression of vascular structural changes and its relation to cytosolic free calcium in hypertensives after nilvadipine treatment.
Topics: Adult; Aged; Analysis of Variance; Calcium; Calcium Channel Blockers; Cytosol; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Parathyroid Hormone; Plethysmography; Probability; Time Factors; Vascular Resistance | 1995 |
Nilvadipine is effective for chronic schizophrenia in a double-blind placebo-controlled study. off.
Topics: Adult; Aged; Calcium Channel Blockers; Chronic Disease; Cross-Over Studies; Double-Blind Method; Dyskinesia, Drug-Induced; Humans; Male; Middle Aged; Nifedipine; Psychiatric Status Rating Scales; Schizophrenia | 1996 |
Nilvadipine in hypertension--experience in ambulatory treatment.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1997 |
Chronic hemorheological effects of the calcium antagonist nilvadipine in essential hypertension.
Topics: Blood Pressure; Blood Viscosity; Calcium Channel Blockers; Chronic Disease; Female; Hematocrit; Humans; Hypertension; Male; Middle Aged; Nifedipine; Serum Albumin | 1997 |
The effects of long-term treatment on left ventricular hypertrophy in patients with essential hypertension: relation to changes in neurohumoral factors.
Topics: Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atrial Natriuretic Factor; Calcium Channel Blockers; Echocardiography; Female; Hemodynamics; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nifedipine; Norepinephrine; Pyridazines; Renin; Thiazepines; Vasodilator Agents | 1997 |
Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aging; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cerebrovascular Disorders; Circadian Rhythm; Cross-Over Studies; Female; Hemodynamics; Humans; Hypertension; Male; Nifedipine; Prazosin; Quality of Life | 1998 |
The effect of nilvadipine, a calcium-channel blocker, on the hemodynamics of retrobulbar vessels in normal-tension glaucoma.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Ciliary Arteries; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Nifedipine; Ophthalmic Artery; Prospective Studies; Retinal Artery; Ultrasonography, Doppler, Color | 1998 |
Effects of nilvadipine, a calcium antagonist, on rabbit ocular circulation and optic nerve head circulation in NTG subjects.
Topics: Adult; Aged; Animals; Blood Flow Velocity; Calcium Channel Blockers; Double-Blind Method; Eye; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Nifedipine; Optic Disk; Rabbits; Reference Values; Regional Blood Flow | 1999 |
Cilnidipine, the N- and L-type calcium channel antagonist, reduced on 24-h urinary catecholamines and C-peptide in hypertensive non-insulin-dependent diabetes mellitus.
Topics: Aged; C-Peptide; Calcium Channel Blockers; Catecholamines; Chromatography, High Pressure Liquid; Cross-Over Studies; Diabetes Mellitus, Type 2; Dihydropyridines; Dopamine; Epinephrine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Norepinephrine | 1999 |
Changes in optic nerve head blood flow and retrobular hemodynamics following calcium-channel blocker treatment of normal-tension glaucoma.
Topics: Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Calcium Channel Blockers; Chronic Disease; Ciliary Arteries; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Middle Aged; Nifedipine; Ophthalmic Artery; Optic Disk; Orbit; Prognosis; Prospective Studies; Retinal Artery; Ultrasonography, Doppler, Color; Vascular Resistance | 1999 |
Pharmacokinetic and dynamic interactions of the angiotensin-converting enzyme inhibitor imidapril with hydrochlorothiazide, bisoprolol and nilvadipine.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Area Under Curve; Bisoprolol; Calcium Channel Blockers; Cross-Over Studies; Diuretics; Double-Blind Method; Drug Interactions; Hemodynamics; Humans; Hydrochlorothiazide; Imidazoles; Imidazolidines; Male; Nifedipine; Sodium Chloride Symporter Inhibitors | 2001 |
Effect of calcium antagonist on cerebral blood flow and oxygen metabolism in patients with hypertension and chronic major cerebral artery occlusion: a positron emission tomography study.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Carotid Stenosis; Cerebrovascular Circulation; Female; Follow-Up Studies; Humans; Hypertension; Infarction, Middle Cerebral Artery; Male; Middle Aged; Nifedipine; Subtraction Technique; Tomography, Emission-Computed; Treatment Outcome | 2003 |
Effects of nilvadipine and amlodipine in patients with mild to moderate essential hypertension: a double blind, prospective, randomised clinical trial.
Topics: Adolescent; Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Electrocardiography; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Nifedipine; Placebos; Prospective Studies | 2005 |
Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Calcium Channel Blockers; Calcium Channels, T-Type; Cross-Over Studies; Depression, Chemical; Dihydropyridines; Hemodynamics; Humans; Male; Neurotransmitter Agents; Nifedipine; Nitrophenols; Organophosphorus Compounds; Renin; Water-Electrolyte Balance | 2006 |
Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment.
Topics: Aged; Amlodipine; Antihypertensive Agents; Brain; Cerebrovascular Circulation; Cognition Disorders; Humans; Hypertension; Nifedipine; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2007 |
Effect of the Ca antagonist nilvadipine on stroke occurrence or recurrence and extension of asymptomatic cerebral infarction in hypertensive patients with or without history of stroke (PICA Study). 1. Design and results at enrollment.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Cerebral Infarction; Female; Humans; Hypertension; Japan; Magnetic Resonance Imaging; Male; Middle Aged; Nifedipine; Recurrence; Risk Factors; Severity of Illness Index; Stroke; Time Factors; Treatment Outcome | 2007 |
Nilvadipine prevents cognitive decline of patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pressure; Cognition Disorders; Disease Progression; Female; Humans; Male; Nifedipine; Tomography, Emission-Computed, Single-Photon | 2007 |
[Investigation on the blood pressure-independent nephroprotective effect of nilvadipine in type 2 diabetics].
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Function Tests; Male; Middle Aged; Nifedipine; Prospective Studies; Treatment Outcome | 2008 |
A placebo-controlled 3-year study of a calcium blocker on visual field and ocular circulation in glaucoma with low-normal pressure.
Topics: Administration, Oral; Blood Pressure; Calcium Channel Blockers; Choroid; Double-Blind Method; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Nifedipine; Optic Disk; Regional Blood Flow; Visual Fields | 2008 |
Effect of nilvadipine on central visual field in retinitis pigmentosa: a 30-month clinical trial.
Topics: Administration, Oral; Adult; Aged; Calcium Channel Blockers; Disease Progression; Female; Follow-Up Studies; Humans; Lutein; Male; Middle Aged; Nifedipine; Pilot Projects; Prospective Studies; Retinitis Pigmentosa; Tocopherols; Vision Disorders; Visual Field Tests; Visual Fields; Young Adult | 2011 |
Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer's patients--an open-label trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antihypertensive Agents; Apolipoprotein E4; Cognition; Cohort Studies; Executive Function; Female; Genotype; Humans; Male; Middle Aged; Nifedipine | 2012 |
Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antihypertensive Agents; Blood Pressure; Female; Humans; Male; Middle Aged; Nifedipine | 2011 |
Long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study.
Topics: Adult; Aged; Calcium Channel Blockers; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifedipine; Retinitis Pigmentosa; Visual Fields | 2013 |
NILVAD protocol: a European multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calcium Channel Blockers; Double-Blind Method; Europe; Female; Humans; Male; Middle Aged; Nifedipine; Severity of Illness Index; Treatment Outcome | 2014 |
European multicentre double-blind placebo-controlled trial of Nilvadipine in mild-to-moderate Alzheimer's disease-the substudy protocols: NILVAD frailty; NILVAD blood and genetic biomarkers; NILVAD cerebrospinal fluid biomarkers; NILVAD cerebral blood flo
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E3; Biomarkers; Calcium Channel Blockers; Cerebrovascular Circulation; Double-Blind Method; Europe; Female; Frailty; Genetic Markers; Humans; Male; Nifedipine; Peptide Fragments; Research Design | 2016 |
Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calcium Channel Blockers; Cognitive Dysfunction; Disease Progression; Double-Blind Method; Europe; Female; Humans; Male; Middle Aged; Nifedipine; Nootropic Agents; Treatment Outcome | 2018 |
Blood Pressure Lowering With Nilvadipine in Patients With Mild-to-Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Europe; Female; Humans; Hypertension; Hypotension, Orthostatic; Male; Middle Aged; Nifedipine; Posture; Prevalence; Risk Assessment; Risk Factors; Severity of Illness Index; Time Factors; Treatment Outcome | 2019 |
Effects of Nilvadipine on Cerebral Blood Flow in Patients With Alzheimer Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calcium Channel Blockers; Cerebrovascular Circulation; Double-Blind Method; Female; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Netherlands; Nifedipine; Prognosis; Reference Values; Risk Assessment; Severity of Illness Index; Treatment Outcome; Ultrasonography, Doppler | 2019 |
Blood Pressure Variability and Progression of Clinical Alzheimer Disease.
Topics: Aged; Alzheimer Disease; Antihypertensive Agents; Blood Pressure Determination; Cognition Disorders; Confidence Intervals; Disease Progression; Double-Blind Method; Female; Humans; Hypertension; Linear Models; Male; Mental Status and Dementia Tests; Middle Aged; Multivariate Analysis; Nifedipine; Prognosis; Risk Assessment; Severity of Illness Index | 2019 |
Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Cholinergic Antagonists; Cognitive Dysfunction; Disability Evaluation; Disease Progression; Female; Humans; Male; Neuropsychological Tests; Nifedipine; Risk Factors; Severity of Illness Index | 2020 |
174 other study(ies) available for nifedipine and nilvadipine
| Article | Year |
|---|---|
Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dogs; Female; Heart Rate; Indicators and Reagents; Male; Molecular Structure; Pyrimidines; Rats; Rats, Inbred SHR; Receptors, Nicotinic; Structure-Activity Relationship; Vasodilator Agents | 1989 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Digoxin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Gene Expression; Humans; Nifedipine; Paclitaxel; RNA, Messenger; Swine; Tritium; Tumor Cells, Cultured; Verapamil; Vinblastine | 2002 |
Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.
Topics: Carboxylic Acids; Cytochrome P-450 Enzyme System; Esters; Humans; Hydrolysis; Microsomes; Models, Molecular; Molecular Structure; Prodrugs; Quantum Theory; Signal Transduction | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Effect of nilvadipine on balloon catheterization-induced intimal thickening of the coronary artery in miniature pigs.
Topics: Angioplasty, Balloon, Coronary; Animals; Calcium Channel Blockers; Catheterization; Coronary Artery Disease; Coronary Vessels; Endothelium, Vascular; Female; Nifedipine; Swine; Swine, Miniature | 1992 |
Advances in antihypertensive treatment--profile of a new dihydropyridine. Proceedings of the 1st Nilvadipine Symposium. Munich, May 16, 1992.
Topics: Antihypertensive Agents; Humans; Hypertension; Nifedipine | 1992 |
Nilvadipine in hypertension with renal dysfunction.
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure; Creatinine; Female; Heart Rate; Humans; Hypertension; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Nifedipine; Renin | 1992 |
The effect of nilvadipine, a dihydropyridine type calcium channel blocker, on local cerebral blood flow in rats.
Topics: Animals; Calcium Channel Blockers; Cerebrovascular Circulation; Male; Nifedipine; Rats; Rats, Inbred Strains; Regional Blood Flow | 1992 |
Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Decerebrate State; Fatty Acids, Nonesterified; Male; Nicardipine; Nifedipine; Rats; Rats, Sprague-Dawley | 1992 |
Effect of single oral administration of nilvadipine on cerebral blood flow in chronic cerebral infarction.
Topics: Administration, Oral; Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Cerebral Infarction; Cerebrovascular Circulation; Chronic Disease; Female; Humans; Male; Middle Aged; Nifedipine; Radionuclide Imaging | 1992 |
[Calcium antagonists have a favorable long-term effect on lipid metabolism. Dr. K. P. Pollack presents results of his studies. Interview by Christine Schaefer].
Topics: Antihypertensive Agents; Calcium Channel Blockers; Humans; Hypertension; Lipids; Nifedipine | 1992 |
Periodicity of insulin secretion comprises multiple cycles with different duration in perfused rat islets.
Topics: Activity Cycles; Animals; Calcimycin; Calcium Channel Blockers; Cells, Cultured; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Nifedipine; Perfusion; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Theophylline | 1992 |
A case of nephrotic syndrome and renal dysfunction in a pregnant woman with diabetes mellitus.
Topics: Adult; Basement Membrane; Biopsy; Calcium Channel Blockers; Capillaries; Diabetic Nephropathies; Endothelium, Vascular; Female; Glomerular Mesangium; Humans; Insulin; Kidney Function Tests; Kidney Glomerulus; Nephrotic Syndrome; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy in Diabetics; Pregnancy Trimester, Third; Puerperal Disorders | 1992 |
Effects of nilvadipine on neuronal function in the ischemic cat brain.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Evoked Potentials, Somatosensory; Female; Male; Neurons; Nicardipine; Nifedipine | 1992 |
Elevated plasma nilvadipine concentration after single and chronic oral administration to patients with chronic liver disease.
Topics: Administration, Oral; Calcium Channel Blockers; Chronic Disease; Hemodynamics; Hepatitis; Humans; Liver Cirrhosis; Nifedipine | 1992 |
Inhibition by nilvadipine of ischemic and carrageenan paw edema as well as of superoxide radical production from neutrophils and xanthine oxidase.
Topics: Animals; Calcimycin; Carrageenan; Edema; Free Radicals; Ischemia; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nifedipine; Rats; Rats, Inbred Strains; Superoxides; Tetradecanoylphorbol Acetate; Xanthine Oxidase | 1991 |
Acute hemodynamic effects of nilvadipine, a new calcium channel blocker, in patients with congestive heart failure.
Topics: Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Regional Blood Flow | 1990 |
Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Nicardipine; Nifedipine; Rats; Rats, Inbred SHR | 1991 |
Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine.
Topics: Aged; Aged, 80 and over; Ambulatory Care; Blood Pressure; Blood Pressure Determination; Calcium Channel Blockers; Circadian Rhythm; Female; Humans; Hypertension; Male; Monitoring, Physiologic; Nifedipine | 1991 |
Studies on nilvadipine. I. Synthesis and structure-activity relationships of 1,4-dihydropyridines containing novel substituents at the 2-position.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Coronary Circulation; Nifedipine; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1991 |
[Ca++ antagonist and acute brain ischemia: effects of nilvadipine and nicardipine on middle cerebral artery occlusion in rats].
Topics: Acute Disease; Animals; Calcium Channel Blockers; Cerebral Infarction; Constriction; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Nicardipine; Nifedipine; Rats; Rats, Inbred Strains | 1991 |
Attenuated neuropathology by nilvadipine after middle cerebral artery occlusion in rats.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Cerebral Infarction; Male; Neurons; Nifedipine; Rats; Rats, Inbred Strains | 1991 |
Effects of the calcium antagonist nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Cerebral Infarction; Cerebrovascular Circulation; Male; Nifedipine; Rats; Rats, Inbred SHR | 1991 |
Effects of a Ca2+ entry blocker (nilvadipine) on acute focal cerebral ischemia in rats.
Topics: Acute Disease; Animals; Brain; Brain Edema; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Male; Nifedipine; Rats; Rats, Inbred Strains | 1991 |
Protective effects of calcium channel blockers on hydrogen peroxide induced increases in endothelial permeability.
Topics: Albumins; Calcium Channel Blockers; Capillary Permeability; Cell Membrane Permeability; Cells, Cultured; Diltiazem; Electric Conductivity; Endothelium, Vascular; Humans; Hydrogen Peroxide; Nicardipine; Nifedipine; Verapamil | 1990 |
Effects of nilvadipine on cerebral circulation and metabolism in cats.
Topics: Animals; Blood Pressure; Brain; Calcium Channel Blockers; Carbon Dioxide; Cats; Cerebrovascular Circulation; Nifedipine; Oxygen Consumption | 1990 |
Calcium channel blockers reverse the sustained elevation of blood pressure induced by chronic infusion of endothelin in conscious rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Endothelins; Hypertension; Male; Nifedipine; Peptides; Rats; Rats, Inbred Strains; Sodium | 1990 |
Effects of calcium channel entry blockers, nifedipine and nilvadipine, on colonic motor activity.
Topics: Acetylcholine; Animals; Blood Pressure; Colon; Dogs; Electric Stimulation; Female; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Potassium Chloride; Sincalide; Substance P | 1986 |
Prolonged inhibitory effects of nilvadipine (FR34235) following washout in isolated rabbit aorta and mesenteric artery.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Diltiazem; Female; In Vitro Techniques; Male; Mesenteric Arteries; Nicardipine; Nifedipine; Norepinephrine; Potassium Chloride; Rabbits; Vasodilator Agents | 1988 |
Effects of antihypertensive drugs on renal function and atrial natriuretic polypeptide in spontaneously hypertensive rats with renal ablation.
Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Calcium Channel Blockers; Captopril; Dihydropyridines; Indapamide; Kidney; Male; Nephrectomy; Nifedipine; Rats; Rats, Inbred SHR; Reference Values | 1989 |
Inhibition of histamine release from rat hypothalamic slices by omega-conotoxin GVIA, but not by nilvadipine, a dihydropyridine derivative.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Histamine; Hypothalamus; In Vitro Techniques; Male; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Rats; Rats, Inbred Strains | 1989 |
Suppression of atherogenesis in cholesterol-fed rabbits treated with nilvadipine, a new vasoselective calcium entry blocker.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Blood Pressure; Calcium; Calcium Channel Blockers; Cholesterol; Liver; Male; Myocardium; Nicardipine; Nifedipine; Rabbits | 1989 |
Sex differences in the metabolism and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats.
Topics: Animals; Bile; Calcium Channel Blockers; Female; Injections, Intravenous; Kinetics; Male; Nifedipine; Rats; Rats, Inbred Strains; Sex Characteristics | 1989 |
Differential activities of two distinct endothelin family peptides on ileum and coronary artery.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Endothelins; Endothelium, Vascular; Gastrointestinal Hormones; Guinea Pigs; Ileum; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Nifedipine; Peptides; Swine; Vasoconstriction | 1989 |
Stereoselective disposition of nilvadipine, a new dihydropyridine calcium antagonist, in the rat and dog.
Topics: Administration, Oral; Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dogs; Female; In Vitro Techniques; Injections, Intravenous; Male; Nifedipine; Protein Binding; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity | 1989 |
Early detection of myocardial ischemia by myocardial free fatty acid extraction in patients with exercise-induced angina pectoris.
Topics: Angina Pectoris; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Coronary Disease; Exercise Test; Fatty Acids, Nonesterified; Hemodynamics; Humans; Nifedipine; Supination | 1989 |
Binding of the new calcium entry blocker nilvadipine to rat aortic and guinea pig left ventricular membranes.
Topics: Animals; Calcium Channel Blockers; In Vitro Techniques; Male; Membranes; Microsomes; Myocardium; Nifedipine; Rats; Rats, Inbred Strains | 1989 |
The effects of the calcium entry blockers, nilvadipine and nitrendipine, on endotoxin-induced disseminated intravascular coagulation.
Topics: Agglutination Tests; Animals; Disseminated Intravascular Coagulation; Endotoxins; Fibrin Fibrinogen Degradation Products; Fibrinogen; Injections, Intravenous; Male; Nifedipine; Nitrendipine; Platelet Count; Premedication; Rats; Rats, Inbred Strains | 1989 |
[Early recognition of exercise-induced myocardial ischemia by plasma free fatty acid].
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Coronary Disease; Exercise Test; Fatty Acids, Nonesterified; Female; Humans; Lactates; Lactic Acid; Male; Middle Aged; Myocardium; Nifedipine | 1989 |
Smooth muscle cell migration induced by inflammatory cell products and its inhibition by a potent calcium antagonist, nilvadipine.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cells, Cultured; Chemotaxis; Exudates and Transudates; Inflammation; Interleukin-1; Leukotriene B4; Male; Muscle, Smooth, Vascular; Nifedipine; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains | 1988 |
Nilvadipine attenuates ischemic degradation of gerbil brain cytoskeletal proteins.
Topics: Animals; Brain; Brain Ischemia; Calmodulin-Binding Proteins; Clathrin; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Gerbillinae; Male; Microtubule-Associated Proteins; Nicardipine; Nifedipine; Nimodipine | 1989 |
Protective action of calcium entry blockers in endotoxin shock.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Escherichia coli; Heart Rate; Male; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Shock, Septic; Verapamil | 1986 |
Role of receptor reserve in the inhibition of alpha-1 adrenoceptor-mediated pressor responses by calcium antagonists in the pithed rat.
Topics: 2-Naphthylamine; Animals; Blood Pressure; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Decerebrate State; Dose-Response Relationship, Drug; Male; Nifedipine; Phenoxybenzamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetrahydronaphthalenes | 1986 |
Effects of nilvadipine on the cardiovascular system in experimental animals.
Topics: Animals; Calcium; Calcium Channel Blockers; Coronary Disease; Coronary Vessels; Dogs; Female; Guinea Pigs; Heart; Heart Atria; Hemodynamics; Hypertension; Hypertension, Renal; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1988 |
Slow dissociation of the new slow-onset and long-acting calcium antagonist benidipine hydrochloride from 3H-nitrendipine binding sites.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Male; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred Strains | 1988 |
Protective action of a calcium antagonist, nilvadipine, against aortic calcium deposition--a pathogenic factor in atherosclerosis.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Ergocalciferols; In Vitro Techniques; Male; Microscopy, Electron, Scanning; Nifedipine; Rats; Rats, Inbred F344 | 1988 |
Effect of the calcium antagonist nilvadipine on haemodynamics at rest and during cold stimulation in essential hypertension.
Topics: Adult; Aged; Calcium Channel Blockers; Catecholamines; Cold Temperature; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Renin; Vascular Resistance | 1987 |
Pharmacokinetics of nilvadipine, a new dihydropyridine calcium antagonist, in mice, rats, rabbits and dogs.
Topics: Animals; Calcium Channel Blockers; Carbon Radioisotopes; Dogs; Female; Half-Life; Male; Mice; Nifedipine; Rabbits; Rats; Species Specificity | 1988 |
Oxidation of nilvadipine, a new dihydropyridine calcium antagonist, to the corresponding pyridine by rat liver microsomes.
Topics: Age Factors; Animals; Calcium Channel Blockers; Female; Male; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Pyridines; Rats; Rats, Inbred Strains; Sex Factors | 1988 |
Multiple-dose pharmacokinetics of nilvadipine in healthy volunteers.
Topics: Administration, Oral; Adult; Humans; Male; Nifedipine; Stereoisomerism; Time Factors | 1988 |
Stereoselective oxidation and plasma protein binding of nilvadipine, a new dihydropyridine calcium antagonist, in man.
Topics: Blood Proteins; Calcium Channel Blockers; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Nifedipine; Oxidation-Reduction | 1988 |
Absorption, distribution and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs.
Topics: Animals; Bile; Calcium Channel Blockers; Dogs; Feces; Intestinal Absorption; Male; Nifedipine; Rats; Rats, Inbred Strains; Species Specificity; Tissue Distribution | 1987 |
Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs.
Topics: Animals; Bile; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dogs; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Nifedipine; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Antihypertensive effect of a new calcium channel blocker, FK 235, in essential hypertension.
Topics: Adult; Aged; Aldosterone; Antihypertensive Agents; Calcium Channel Blockers; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Renin | 1986 |
Plasma protein binding of nilvadipine, a new dihydropyridine calcium antagonist, in man and dog.
Topics: Animals; Blood Proteins; Calcium Channel Blockers; Carbon Radioisotopes; Dogs; Humans; Lipoproteins; Male; Nifedipine; Orosomucoid; Protein Binding; Serum Albumin | 1987 |
Determination of nilvadipine in plasma and urine by capillary column gas chromatography with electron-capture detection.
Topics: Animals; Calcium Channel Blockers; Chromatography, Gas; Dogs; Drug Stability; Electrochemistry; Male; Nifedipine; Species Specificity | 1987 |
Determination of (+)- and (-)-nilvadipine in human plasma using chiral stationary-phase liquid chromatography and gas chromatography-mass spectrometry, and a preliminary pharmacokinetic study in humans.
Topics: Adult; Calcium Channel Blockers; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Male; Nifedipine; Stereoisomerism | 1987 |
Antiatherogenic activity of FR34235 (Nilvadipine), a new potent calcium antagonist. Effect on cuff-induced intimal thickening of rabbit carotid artery.
Topics: Animals; Arteriosclerosis; Calcium Channel Blockers; Carotid Arteries; Carotid Artery Diseases; Male; Muscle, Smooth, Vascular; Nifedipine; Rabbits | 1987 |
Effects of a new second generation calcium channel blocker, nilvadipine (FR34235), on exercise-induced hemodynamic changes in stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Coronary Circulation; Electrocardiography; Exercise Test; Female; Heart; Hemodynamics; Humans; Male; Middle Aged; Nifedipine | 1987 |
Plasma levels of (+)- and (-)-nilvadipine after oral dosing with racemic (+)-nilvadipine in man.
Topics: Administration, Oral; Adult; Calcium Channel Blockers; Half-Life; Humans; Male; Nifedipine; Stereoisomerism | 1987 |
Pharmacokinetics of nilvadipine in healthy volunteers.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Humans; Male; Nifedipine; Pulse | 1987 |
Effect of two different meals on bioavailability of nilvadipine in healthy volunteers.
Topics: Adult; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Food; Humans; Male; Nifedipine | 1987 |
Effects of calcium antagonistic drugs on the electrical activity of rabbit sino-atrial node.
Topics: Animals; Atropine; Calcium Channel Blockers; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Nifedipine; Rabbits; Sinoatrial Node; Verapamil | 1986 |
New dihydropyridine drug, nilvadipine, blocks the calcium slow action potential in rat-cultured aortic smooth muscle cells.
Topics: Action Potentials; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits | 1986 |
Structural studies of a new dihydropyridine calcium channel antagonist, nilvadipine.
Topics: Calcium Channel Blockers; Chemical Phenomena; Chemistry; Molecular Conformation; Nifedipine | 1986 |
Determination of nilvadipine in human plasma by capillary column gas chromatography-negative-ion chemical-ionization mass spectrometry.
Topics: Calcium Channel Blockers; Drug Stability; Electrochemistry; Gas Chromatography-Mass Spectrometry; Humans; Nifedipine; Solvents | 1985 |
Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: systemic and coronary hemodynamics with and without combined beta adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dogs; Female; Heart Rate; Hemodynamics; Hydralazine; Male; Nifedipine; Nisoldipine; Nitrendipine; Propranolol; Vasodilator Agents | 1984 |
Comparative effects of FR 34235, a new slow channel calcium blocker, and nifedipine on hemodynamics and myocardial oxygen consumption in the anesthetized dog.
Topics: Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dogs; Female; Hemodynamics; Male; Myocardium; Nifedipine; Oxygen Consumption | 1983 |
Selective improvement in subendocardial perfusion distal to a flow-limiting coronary artery stenosis: effects of the new calcium channel blocking agent, FR 34235, nifedipine and diltiazem.
Topics: Animals; Benzazepines; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Dogs; Female; Male; Nifedipine; Oxygen Consumption; Vasodilation | 1984 |
Comparative actions of dihydropyridine slow channel calcium blocking agents in conscious dogs: alterations in baroreflex sensitivity.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dogs; Female; Heart Rate; Hydralazine; Male; Nifedipine; Nisoldipine; Nitrendipine; Pressoreceptors | 1984 |
The inhibitory action of FR 34235 (a new Ca2+ entry blocker) as compared to nimodipine and nifedipine on the contractile response to norepinephrine, potassium and 5-hydroxytryptamine in rabbit basilar artery.
Topics: Animals; Basilar Artery; Calcium Channel Blockers; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicotinic Acids; Nifedipine; Nimodipine; Norepinephrine; Potassium; Pyridines; Rabbits; Serotonin | 1983 |
Beneficial effects of the dihydropyridine calcium antagonist, FR 34235, in a chronic coronary occlusion model.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Dogs; Hemodynamics; Nifedipine; Pyridines | 1982 |
Effects of KRN4884, a novel K channel opener, on the cardiovascular system in anesthetized dogs: a comparison with levcromakalim, nilvadipine, and nifedipine.
Topics: Anesthesia; Animals; Antihypertensive Agents; Aorta; Benzopyrans; Calcium Channel Blockers; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Nifedipine; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1995 |
Prominent inhibitory effects of tranilast on migration and proliferation of and collagen synthesis by vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Cell Division; Cell Movement; Cells, Cultured; Colchicine; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Imidazoles; Male; Mitomycin; Muscle, Smooth, Vascular; Nifedipine; ortho-Aminobenzoates; Pancreatic Elastase; Phosphodiesterase Inhibitors; Pyridones; Rats; Rats, Inbred WKY | 1994 |
In vivo effects of the Ca2+ entry blocker nilvadipine on brain surface microvessels in rats.
Topics: Animals; Arterioles; Blood Gas Analysis; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Cerebrovascular Circulation; Fluoresceins; Male; Microcirculation; Microscopy, Fluorescence; Nifedipine; Rats; Rats, Sprague-Dawley; Vasomotor System | 1994 |
Tacrolimus (FK506)-induced nephrotoxicity in spontaneous hypertensive rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arterioles; Blood Urea Nitrogen; Creatinine; Hypertension; Kidney; Kidney Diseases; Male; Nifedipine; Rats; Rats, Inbred SHR; Renal Artery; Renin; Tacrolimus; Thromboxane B2; Vasoconstriction | 1994 |
Effects of Ca-antagonists on oxidative susceptibility of low density lipoprotein (LDL).
Topics: Adult; Amlodipine; Apolipoproteins; Calcium Channel Blockers; Electrophoresis, Agar Gel; Fatty Acids; Female; Humans; Hypertension; In Vitro Techniques; Lipids; Lipoproteins, LDL; Male; Middle Aged; Nifedipine; Oxidation-Reduction; Thiobarbituric Acid Reactive Substances | 1995 |
Sex-dependent and independent renal excretion of nilvadipine metabolites in rat: evidence for a sex-dependent active secretion in kidney.
Topics: Animals; Antihypertensive Agents; Bile; Blood Proteins; Female; Glomerular Filtration Rate; Kidney; Male; Metabolic Clearance Rate; Nifedipine; Potentiometry; Probenecid; Protein Binding; Rats; Rats, Sprague-Dawley; Sex Characteristics | 1995 |
[Nilvadipine in the hypertensive elderly. Risk factor for cerebral insufficiency. Study report].
Topics: Aged; Antihypertensive Agents; Brain; Calcium Channel Blockers; Cerebrovascular Circulation; Humans; Hypertension; Nifedipine | 1993 |
Different effects of an angiotensin converting enzyme inhibitor and a calcium antagonist on protein metabolism in rats with right ventricular hypertrophy.
Topics: Absorptiometry, Photon; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Collagen; Electrophoresis; Heart Ventricles; Hypertrophy, Right Ventricular; Indans; Male; Myocardial Contraction; Myocardium; Myosins; Nifedipine; Organ Size; Rats; Rats, Sprague-Dawley; Ventricular Pressure | 1994 |
Interaction of renal excretion between nilvadipine metabolites, M3 and M7 in rats: characterization of sex-dependent and sex-independent active secretion in the kidney.
Topics: Animals; Biological Transport, Active; Calcium Channel Blockers; Drug Interactions; Female; Glomerular Filtration Rate; Infusions, Intravenous; Injections, Intravenous; Kidney; Kidney Tubules; Male; Nifedipine; Protein Binding; Rats; Rats, Sprague-Dawley; Sex Characteristics | 1994 |
Therapeutic effects of nilvadipine on rat focal cerebral ischemia.
Topics: Animals; Blood Pressure; Brain; Calcium Channel Blockers; Cerebral Arteries; Cerebral Infarction; Ischemic Attack, Transient; Nifedipine; Optic Chiasm; Rats; Rats, Sprague-Dawley | 1994 |
Contrasting effects of an angiotensin converting enzyme inhibitor and a calcium antagonist on calcium transients in isolated rat cardiac myocytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Hypertrophy, Right Ventricular; Indans; Male; Monocrotaline; Myocardial Contraction; Myocardium; Nifedipine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta | 1994 |
Studies on nilvadipine. IV. Synthesis of deuteriated and optically active isopropyl 2-cyano-3-methoxycarbonyl-4-(3-nitrophenyl)-6-methyl-1,4- dihydropyridine-5-carboxylate (nilvadipine).
Topics: Antihypertensive Agents; Deuterium; Nifedipine; Stereoisomerism | 1994 |
[Effects of calcium antagonists on prostaglandin E2 production in cultured human amnion cells].
Topics: Amnion; Calcium Channel Blockers; Cells, Cultured; Depression, Chemical; Diltiazem; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Female; Humans; Interleukin-1; Nicardipine; Nifedipine; Phospholipases A; Phospholipases A2; Pregnancy; Verapamil | 1994 |
Effect of nilvadipine on the development of neurological deficits in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Calcium Channel Blockers; Cerebrovascular Disorders; Eating; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Sodium Chloride; Time Factors | 1994 |
Erythrocyte sodium cannot predict hypotensive effects of calcium channel blockers.
Topics: Age Factors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Erythrocytes; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Renin; Sodium | 1993 |
[Effects of nilvadipine on membrane potential in cultured neuroblastoma-glioma hybrid NG108-15 cells].
Topics: Animals; Calcium Channel Blockers; Electrophysiology; Glioma; Membrane Potentials; Mice; Neuroblastoma; Nifedipine; Rats; Tumor Cells, Cultured | 1994 |
Isolation and characterization of four cytochrome P450 isozymes from untreated and phenobarbital-treated beagle dogs.
Topics: Amino Acid Sequence; Animals; Catalysis; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dogs; Electrophoresis, Polyacrylamide Gel; Hydroxylation; Immunoblotting; Isoenzymes; Male; Microsomes, Liver; Molecular Sequence Data; Molecular Weight; Nifedipine; Phenobarbital; Steroid 16-alpha-Hydroxylase; Testosterone | 1994 |
Effect of nilvadipine on adrenocortical cell proliferation and steroidogenesis in early stage of adrenal regeneration.
Topics: Adrenal Cortex; Animals; Calcium; Calcium Channel Blockers; Cell Division; Corticosterone; Male; Nifedipine; Rats; Rats, Wistar; Regeneration | 1993 |
Effect of a Ca2+ entry blocker, nilvadipine, on hearing disturbances and equilibrium dysfunction caused by microcirculatory disorders of the rat inner ear.
Topics: Acoustic Stimulation; Action Potentials; Analysis of Variance; Animals; Calcium Channel Blockers; Cochlea; Ear, Inner; Flunarizine; Hearing Disorders; Laser-Doppler Flowmetry; Nifedipine; Rats; Rats, Wistar; Regional Blood Flow; Sensation Disorders; Ultraviolet Rays | 1993 |
Protective effect of nilvadipine on focal cerebral ischemia in spontaneously hypertensive rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Dose-Response Relationship, Drug; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1996 |
Effects of nilvadipine (a dihydropyridine-type calcium entry blocker) on cerebral blood flow in acute experimental brain ischemia in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Drug Evaluation, Preclinical; Heart Rate; Hypotension; Injections, Intra-Arterial; Male; Nifedipine; Rats; Rats, Sprague-Dawley | 1996 |
Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Felodipine; Fumarates; Heart; Iron; Lipid Peroxidation; Male; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Determination of the unbound concentration of hydrophobic drugs in albumin solutions by high-performance frontal analysis using a diol-silica column.
Topics: Chromatography, High Pressure Liquid; Diclofenac; Nifedipine; Protein Binding; Serum Albumin; Stereoisomerism | 1994 |
Effect of nilvadipine on high-voltage activated Ca2+ channels in rat CNS neurons.
Topics: Animals; Brain; Cadmium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; In Vitro Techniques; Kinetics; Membrane Potentials; Nerve Tissue Proteins; Neurons; Nicardipine; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Patch-Clamp Techniques; Peptides; Rats; Rats, Wistar; Spider Venoms | 1997 |
Effect of long-term topical betaxolol on tissue circulation in the iris and optic nerve head.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Betaxolol; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Intraocular Pressure; Iris; Nifedipine; Optic Disk; Rabbits | 1997 |
Effectiveness of nilvadipine in two cases of chronic schizophrenia.
Topics: Calcium Channel Blockers; Chronic Disease; Dyskinesia, Drug-Induced; Humans; Male; Middle Aged; Nifedipine; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1995 |
KRN4884, a novel K channel opener: antihypertensive effects in conscious renal hypertensive dogs.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Calcium Channel Blockers; Cromakalim; Dogs; Female; Hypertension, Renal; Male; Nifedipine; Potassium Channels; Pyridines; Pyrroles | 1997 |
Enhanced efficacy of nilvadipine in hypertensives whose raised ambulatory blood pressure is sustained during sleep.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Sleep | 1998 |
Nilvadipine inhibits acute rise of aqueous flare and intraocular pressure induced by prostaglandin E2 in pigmented rabbits.
Topics: Animals; Anterior Eye Segment; Aqueous Humor; Calcium Channel Blockers; Dinoprostone; Dose-Response Relationship, Drug; Eye Proteins; Injections, Intravenous; Intraocular Pressure; Male; Nicardipine; Nifedipine; Ophthalmic Solutions; Rabbits; Tonometry, Ocular | 1998 |
Three assumptions: ocular blood flow and glaucoma.
Topics: Blood Flow Velocity; Calcium Channel Blockers; Ciliary Arteries; Color Perception; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Nifedipine; Nimodipine; Optic Nerve; Retinal Artery; Ultrasonography, Doppler, Color; Visual Fields | 1998 |
Differential effects of antihypertensive drugs with differing pharmacological properties on the basal ambulatory blood pressure. Japanese Ambulatory Pressure-ANtihypertensive Effects SEarching study group.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Bisoprolol; Blood Pressure; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Female; Humans; Lisinopril; Male; Middle Aged; Nifedipine; Office Visits; Systole | 1998 |
Effect of nilvadipine on the voltage-dependent Ca2+ channels in rat hippocampal CA1 pyramidal neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amlodipine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Flunarizine; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar | 1998 |
Effects of treatment with nilvadipine on cerebral ischemia in rats.
Topics: Animals; Antihypertensive Agents; Brain; Calcium Channel Blockers; Cerebral Infarction; Hypertension; Ischemic Attack, Transient; Male; Nifedipine; Rats; Rats, Inbred SHR; Treatment Outcome | 1998 |
Effects of KRN4884 (a novel K+ channel opener), levcromakalim, nilvadipine and propranolol on endothelin-1-induced heart disorders in anesthetized rats.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Bronchoconstrictor Agents; Cromakalim; Electrocardiography; Endothelin-1; Heart Diseases; Heart Rate; Injections, Intra-Arterial; Male; Methacholine Chloride; Nifedipine; Potassium Channels; Propranolol; Pyridines; Rats; Rats, Wistar | 1998 |
Renal afferent and efferent arteriolar dilation by nilvadipine: studies in the isolated perfused hydronephrotic kidney.
Topics: Anesthesia; Angiotensin II; Animals; Antihypertensive Agents; Calcium Channel Blockers; Hydronephrosis; Male; Microcirculation; Nifedipine; Perfusion; Rats; Rats, Wistar; Renal Artery; Vasoconstriction; Vasodilation | 1999 |
Antihypertensive properties of KRN4884, a novel long-lasting potassium channel opener.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Calcium Channel Blockers; Cromakalim; Dose-Response Relationship, Drug; Hypertension; In Vitro Techniques; Male; Nifedipine; Pyridines; Rats; Rats, Inbred SHR; Rats, Wistar; Time Factors; Vasodilation | 1999 |
Effects of two calcium channel blockers on messenger RNA expression of endothelin-1 and nitric oxide synthase in cardiovascular tissue of hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Blotting, Southern; Brain; Calcium Channel Blockers; Cardiovascular System; Disease Models, Animal; Endothelin-1; Follow-Up Studies; Heart; Hypertension; Kidney; Male; Nifedipine; Nitric Oxide Synthase; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Inhibitory effect of nilvadipine on disruption of blood-aqueous barrier induced by prostaglandin E2 application in pigmented rabbits: A morphologic study.
Topics: Animals; Aqueous Humor; Blood-Aqueous Barrier; Calcium Channel Blockers; Dinoprostone; Dose-Response Relationship, Drug; Eye; Horseradish Peroxidase; Iris; Male; Microscopy, Electron; Nifedipine; Rabbits | 1999 |
Different effects of L-type and T-type calcium channel blockers on the hypnotic potency of triazolam and zolpidem in rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, T-Type; Drug Interactions; Flunarizine; Hypnotics and Sedatives; Male; Nifedipine; Pyridines; Rats; Rats, Wistar; Sleep, REM; Triazolam; Zolpidem | 1999 |
Effect of lomerizine, a new Ca(2+)channel blocker, on the microcirculation in the optic nerve head in conscious rabbits: a study using a laser speckle technique.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Consciousness; Heart Rate; Intraocular Pressure; Lasers; Male; Microcirculation; Nifedipine; Optic Disk; Piperazines; Rabbits | 1999 |
Effects of nilvadipine on cytokine-levels and soluble factors in collagen disease complicated with essential hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; CD4-CD8 Ratio; Collagen Diseases; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; HLA-DR1 Antigen; Humans; Hypertension; Interleukin-1; Interleukin-6; Leukocyte Common Antigens; Lymphocyte Activation; Male; Middle Aged; Nifedipine; Receptors, Interleukin-2; Retrospective Studies; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; Treatment Outcome; Tumor Necrosis Factor-alpha | 1999 |
Effect of benidipine on depolarizing stimulation-induced increase of intracellular calcium concentration in cultured mouse hippocampal neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Electric Stimulation; Hippocampus; Mice; Neurons; Nicardipine; Nifedipine | 1999 |
Binding analysis of nilvadipine to plasma lipoproteins by capillary electrophoresis-frontal analysis.
Topics: Binding, Competitive; Calcium Channel Blockers; Electrophoresis, Capillary; Humans; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Male; Nifedipine; Protein Binding; Spectrophotometry, Ultraviolet | 1999 |
Regional cerebral blood flow in the patients with depressive disorders.
Topics: Adult; Calcium Channel Blockers; Case-Control Studies; Cerebrovascular Circulation; Depression; Depressive Disorder; Humans; Nifedipine; Tomography, X-Ray Computed; Xenon | 2000 |
Nilvadipine protects low-density lipoprotein cholesterol from in vivo oxidation in hypertensive patients with risk factors for atherosclerosis.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Arteriosclerosis; Case-Control Studies; Cholesterol, LDL; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Oxidative Stress; Risk Factors | 2000 |
Relationship between the effect of carbon dioxide inhalation or nilvadipine on orbital blood flow in normal-tension glaucoma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aged; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Carbon Dioxide; Ciliary Arteries; Female; Glaucoma, Open-Angle; Humans; Male; Middle Aged; Nifedipine; Ophthalmic Artery; Orbit; Prospective Studies; Regional Blood Flow; Retinal Artery; Ultrasonography, Doppler, Color | 2000 |
X-ray crystallographic characterization of nilvadipine monohydrate and its phase transition behavior.
Topics: Calcium Channel Blockers; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Nifedipine | 2000 |
[Effects of nilvadipine on retinal microcirculation and systemic circulation].
Topics: Animals; Blood Circulation; Calcium Channel Blockers; Dogs; Drug Evaluation, Preclinical; Male; Microcirculation; Nifedipine; Retinal Vessels | 2000 |
Identification of photodegradation products of nilvadipine using GC-MS.
Topics: Calcium Channel Blockers; Gas Chromatography-Mass Spectrometry; Nifedipine; Photolysis | 2000 |
Normal-phase TLC separation of enantiomers of 1.4-dihydropyridine derivatives.
Topics: Calcium Channel Blockers; Chromatography, Thin Layer; Dihydropyridines; Felodipine; Methanol; Nifedipine; Solvents; Stereoisomerism | 2001 |
Effect of nilvadipine in weak acidic medium by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.
Topics: Amlodipine; Anticholesteremic Agents; Antioxidants; Bepridil; beta Carotene; Biphenyl Compounds; Buffers; Calcium Channel Blockers; Free Radicals; Hydrogen-Ion Concentration; Nifedipine; Picrates; Probucol | 2001 |
Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits.
Topics: Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Ciliary Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Endothelin-1; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Nifedipine; Optic Disk; Piperazines; Rabbits; Regional Blood Flow | 2001 |
Voltammetric determination of nilvadipine in dosage forms and spiked human urine.
Topics: Antihypertensive Agents; Dosage Forms; Humans; Hydrogen-Ion Concentration; Nifedipine; Polarography; Sensitivity and Specificity | 2001 |
Retinal dysfunction in cancer-associated retinopathy is improved by Ca(2+) antagonist administration and dark adaptation.
Topics: Animals; Antibodies; Antigens, Neoplasm; Calcium Channel Blockers; Calcium-Binding Proteins; Dark Adaptation; Electroretinography; Eye Proteins; Hippocalcin; Injections; Injections, Intraperitoneal; Light; Lipoproteins; Nerve Tissue Proteins; Nifedipine; Paraneoplastic Syndromes; Phosphorylation; Photoreceptor Cells, Vertebrate; Rats; Rats, Inbred BN; Rats, Inbred Lew; Recoverin; Retinal Diseases; Rhodopsin; Vitreous Body | 2001 |
Effect of oxidation of low-density lipoprotein on drug binding affinity studied by high performance frontal analysis-capillary electrophoresis.
Topics: Calcium Channel Blockers; Electrophoresis, Capillary; Lipoproteins, LDL; Molecular Structure; Nifedipine; Oxidation-Reduction; Protein Binding; Sensitivity and Specificity; Verapamil | 2001 |
Spectroscopic and HPLC studies of photodegradation of nilvadipine.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Drug Stability; Kinetics; Nifedipine; Photochemistry; Spectrophotometry, Ultraviolet; Time Factors; Ultraviolet Rays | 2001 |
Carbamazepine decreases antihypertensive effect of nilvadipine.
Topics: Antihypertensive Agents; Antimanic Agents; Carbamazepine; Drug Interactions; Humans; Hypertension; Male; Middle Aged; Nifedipine | 2002 |
The effects of rifampicin on the pharmacokinetics and pharmacodynamics of orally administered nilvadipine to healthy subjects.
Topics: Administration, Oral; Adult; Antibiotics, Antitubercular; Blood Pressure; Calcium Channel Blockers; Drug Interactions; Female; Heart Rate; Humans; Hydrocortisone; Male; Nifedipine; Rifampin | 2002 |
Preservation of retinal morphology and functions in royal college surgeons rat by nilvadipine, a Ca(2+) antagonist.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Caspase 1; Caspase 2; Caspases; Crystallins; Disease Models, Animal; DNA Primers; Electrophoresis, Polyacrylamide Gel; Electroretinography; Eye Proteins; Fluorescent Antibody Technique, Indirect; G-Protein-Coupled Receptor Kinase 1; Injections, Intraperitoneal; Nifedipine; Protein Kinases; Rats; Rats, Mutant Strains; Retina; Retinitis Pigmentosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
Protective effect of nilvadipine against glutamate neurotoxicity in purified retinal ganglion cells.
Topics: Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Culture Techniques; Cell Survival; Diltiazem; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Neuroprotective Agents; Nifedipine; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Retinal Ganglion Cells | 2003 |
Uniformly sized molecularly imprinted polymer for (S)-nilvadipine. Comparison of chiral recognition ability with HPLC chiral stationary phases based on a protein.
Topics: Adsorption; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Hydrophobic and Hydrophilic Interactions; Nifedipine; Polymers; Proteins; Stereoisomerism; Surface Properties | 2003 |
Physicochemical characterization and drug release studies of nilvadipine solid dispersions using water-insoluble polymer as a carrier.
Topics: Calorimetry, Differential Scanning; Carboxymethylcellulose Sodium; Cellulose; Crystallization; Dosage Forms; Drug Carriers; Microscopy, Electron, Scanning; Nifedipine; Povidone; Solubility; Spectroscopy, Fourier Transform Infrared; Time Factors; X-Ray Diffraction | 2003 |
Study of pharmacological effects of nilvadipine on RCS rat retinal degeneration by microarray analysis.
Topics: Animals; Apoptosis; Blotting, Western; Calcium Channel Blockers; Cell Death; Fibroblast Growth Factor 2; Nifedipine; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Retinitis Pigmentosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity; Time Factors | 2003 |
Time course of the change in optic nerve head circulation after an acute increase in intraocular pressure.
Topics: Animals; Blood Circulation; Blood Flow Velocity; Calcium Channel Blockers; Indomethacin; Intraocular Pressure; Laser-Doppler Flowmetry; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ocular Hypertension; Optic Disk; Parasympathectomy; Rabbits; Time Factors | 2003 |
Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats.
Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Calibration; Genes, bcl-2; Glyceraldehyde-3-Phosphate Dehydrogenases; Hippocampus; Male; Maze Learning; Memory Disorders; Nifedipine; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Space Perception | 2003 |
An attempt to stabilize nilvadipine solid dispersion by the use of ternary systems.
Topics: Drug Stability; Nifedipine; Technology, Pharmaceutical | 2003 |
Low expression of rhodopsin kinase in pineal gland in Royal College of Surgeons rat.
Topics: Animals; Arrestin; Blotting, Western; Calcium Channel Blockers; Calcium-Binding Proteins; Disease Models, Animal; Eye Proteins; Fluorescent Antibody Technique, Indirect; G-Protein-Coupled Receptor Kinase 1; Hippocalcin; Lipoproteins; Nerve Tissue Proteins; Nifedipine; Photoreceptor Cells, Vertebrate; Pineal Gland; Protein Kinases; Rats; Rats, Mutant Strains; Recoverin; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse.
Topics: Animals; Calcium Channel Blockers; Caspases; Diltiazem; Electroretinography; Fibroblast Growth Factor 2; Gene Expression; Membrane Proteins; Mice; Mice, Mutant Strains; Microscopy, Electron; Nerve Tissue Proteins; Nicardipine; Nifedipine; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Retinitis Pigmentosa; Synaptogyrins | 2004 |
Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Aorta; Calcium Channel Blockers; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models, Animal; Humans; Male; Mice; Mice, Transgenic; Middle Cerebral Artery; Nifedipine; Organ Culture Techniques; Rats; Vasoconstriction; Vasodilator Agents | 2004 |
Application of nilvadipine solid dispersion to tablet formulation and manufacturing using crospovidone and methylcellulose as dispersion carriers.
Topics: Drug Compounding; Drug Stability; Excipients; Hardness; Methylcellulose; Nifedipine; Particle Size; Povidone; Solubility; Tablets, Enteric-Coated | 2004 |
[Stability of nilvadipine solid dispersion tablet with non-packaging condition].
Topics: Drug Packaging; Drug Stability; Hardness; Humidity; Nifedipine; Tablets; Temperature; X-Ray Diffraction | 2004 |
Effect of nilvadipine, a dihydropyridine calcium antagonist, on cytochrome P450 activities in human hepatic microsomes.
Topics: Calcium Channel Blockers; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Isoenzymes; Microsomes, Liver; Nifedipine | 2004 |
Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Cerebral Infarction; Dihydropyridines; Dose-Response Relationship, Drug; Male; Nifedipine; Rats; Rats, Sprague-Dawley | 2004 |
Nilvadipine attenuates mesangial expansion and glomerular hypertrophy in diabetic db/db mice, a model for type 2 diabetes.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enalapril; Glomerular Mesangium; Hypertrophy; Kidney Function Tests; Lipid Peroxidation; Male; Malondialdehyde; Mice; Nifedipine; Organ Size | 2004 |
Nilvadipine inhibits nuclear factor-kappaB-dependent transcription in hepatic cells.
Topics: Arteriosclerosis; Base Sequence; Electrophoresis; Fibrinogen; Gene Expression; Hepatocytes; Humans; NF-kappa B; Nifedipine; Plasminogen Activator Inhibitor 1; Time Factors; Transcription Factor RelA; Transcription, Genetic | 2004 |
Time course of changes in optic nerve head circulation after acute reduction in intraocular pressure.
Topics: Acute Disease; Animals; Blood Circulation; Blood Circulation Time; Blood Flow Velocity; Calcium Channel Blockers; Enzyme Inhibitors; Indomethacin; Intraocular Pressure; Laser-Doppler Flowmetry; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ocular Hypotension; Optic Disk; Rabbits; Sympathetic Nervous System; Time Factors | 2005 |
Retentivity and enantioselectivity of uniformly-sized molecularly imprinted polymers for (S)-nilvadipine in aqueous and non-aqueous mobile phases.
Topics: Chromatography, High Pressure Liquid; Cross-Linking Reagents; Hydrogen-Ion Concentration; Methacrylates; Nifedipine; Polymers; Pyridines; Solutions; Spectrophotometry, Ultraviolet; Stereoisomerism | 2005 |
Effects of chronic administration with nilvadipine against immunohistochemical changes related to aging in the mouse hippocampus.
Topics: Aging; Animals; Calcium Channel Blockers; Cell Death; Cell Proliferation; Cytoprotection; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Hippocampus; Immunohistochemistry; Male; Memory Disorders; Mice; Mice, Inbred ICR; Nerve Degeneration; Nerve Growth Factors; Neurons; Neuroprotective Agents; Nifedipine; Oxidative Stress; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Ubiquitin | 2005 |
Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine.
Topics: Calcium Channel Blockers; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Compounding; Excipients; Hydrogen-Ion Concentration; Kinetics; Nifedipine; Particle Size; Powders; Solubility; Soybean Oil; Tablets; Waxes | 2005 |
Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): in vivo evaluation.
Topics: Administration, Oral; Animals; Biological Availability; Calcium Channel Blockers; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dogs; Hypromellose Derivatives; Intestinal Absorption; Male; Methylcellulose; Nifedipine; Solubility; Soybean Oil; Tablets, Enteric-Coated; Water | 2006 |
Crystallization rate of amorphous nifedipine analogues unrelated to the glass transition temperature.
Topics: Calorimetry, Differential Scanning; Crystallization; Excipients; Hot Temperature; Hypromellose Derivatives; Methylcellulose; Nifedipine; Nitrendipine; Phase Transition; Polymers; Povidone; Temperature; Transition Temperature; Water | 2007 |
The inhibitory effect of nilvadipine on calcium channels in retinal ganglion cells in goldfish.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Goldfish; In Vitro Techniques; Nifedipine; Patch-Clamp Techniques; Retinal Ganglion Cells | 2006 |
Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Male; Maze Learning; Memory Disorders; Neurons; Nifedipine; Rats; Rats, Wistar; Space Perception | 2007 |
Systemic administration of nilvadipine delays photoreceptor degeneration of heterozygous retinal degeneration slow (rds) mouse.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Disease Models, Animal; Drug Evaluation, Preclinical; Electroretinography; Eye Proteins; Gene Expression Regulation; Mice; Mice, Mutant Strains; Microscopy, Electron; Nifedipine; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Effect of nilvadipine on regional cerebral blood flow in a patient with early Alzheimer disease.
Topics: Aged, 80 and over; Alzheimer Disease; Antihypertensive Agents; Cerebrovascular Circulation; Cysteine; Female; Humans; Hypertension; Nifedipine; Organotechnetium Compounds; Radiopharmaceuticals; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon | 2008 |
Addition of N-carbobenzyloxy-L-tryptophan as a co-template molecule to molecularly imprinted polymer monoliths for (+)-nilvadipine.
Topics: Chromatography, Affinity; Microscopy, Electron, Scanning; Molecular Imprinting; Nifedipine; Polymers; Tryptophan | 2008 |
Photochemical stabilities of some dihydropyridine calcium-channel blockers in powdered pharmaceutical tablets.
Topics: Amlodipine; Calcium Channel Blockers; Drug Stability; Nifedipine; Photochemistry; Powders; Tablets | 2008 |
[A patient with early Alzheimer's disease who showed improvement of cognitive function and cerebral perfusion by combined therapy of nilvadipine and PPAR gamma agonists].
Topics: Aged; Alzheimer Disease; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Calcium Channel Blockers; Cerebrovascular Circulation; Cognition; Humans; Male; Nifedipine; PPAR gamma; Telmisartan | 2008 |
A simple in vitro assay for assessing the reactivity of nitrile containing compounds.
Topics: Cysteine; Drug Discovery; Glutathione; Molecular Structure; Nifedipine; Nitriles | 2009 |
High-throughput formulation screening system for self-microemulsifying drug delivery.
Topics: Drug Delivery Systems; Drug Stability; Emulsions; Ethanol; High-Throughput Screening Assays; Nephelometry and Turbidimetry; Nifedipine; Oils; Particle Size; Robotics; Surface-Active Agents; Time Factors | 2009 |
Design of self-microemulsifying drug delivery systems using a high-throughput formulation screening system.
Topics: Antihypertensive Agents; Biological Availability; Chemistry, Pharmaceutical; Drug Delivery Systems; Emulsions; High-Throughput Screening Assays; Hydrophobic and Hydrophilic Interactions; Lipids; Nifedipine; Particle Size; Robotics; Solubility; Surface-Active Agents | 2010 |
Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis.
Topics: Animals; Blood-Aqueous Barrier; Calcium Channel Blockers; Cell Adhesion; Chemokine CCL2; Diltiazem; Disease Models, Animal; Endotoxins; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Inflammation; Intercellular Adhesion Molecule-1; Leukocyte Count; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nifedipine; Retina; Retinal Vessels; Uveitis | 2010 |
AAV-mediated gene replacement, either alone or in combination with physical and pharmacological agents, results in partial and transient protection from photoreceptor degeneration associated with betaPDE deficiency.
Topics: Animals; Calcium Channel Blockers; Chlorocebus aethiops; Combined Modality Therapy; COS Cells; Cyclic Nucleotide Phosphodiesterases, Type 6; Darkness; Dependovirus; Disease Models, Animal; Female; Genetic Therapy; Genetic Vectors; Homozygote; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nifedipine; Photoreceptor Cells, Vertebrate; Pregnancy; Retinitis Pigmentosa | 2011 |
Factors affecting the absorption of nilvadipine from disintegration-controlled matrix tablet in dogs.
Topics: Animals; Antihypertensive Agents; Area Under Curve; Colon; Delayed-Action Preparations; Dogs; Fasting; Gastrointestinal Transit; Intestinal Absorption; Intestine, Small; Male; Nifedipine; Tablets | 2011 |
Effects of spray drying process parameters on the solubility behavior and physical stability of solid dispersions prepared using a laboratory-scale spray dryer.
Topics: Calcium Channel Blockers; Calorimetry, Differential Scanning; Drug Compounding; Drug Stability; Drug Storage; Excipients; Hot Temperature; Hypromellose Derivatives; Kinetics; Methylcellulose; Microscopy, Electron, Scanning; Models, Chemical; Nifedipine; Powder Diffraction; Powders; Quality Control; Solubility; Suspensions; Transition Temperature | 2013 |
Changes in optic nerve head circulation in response to vasoactive agents: intereye comparison in monkeys with experimental unilateral glaucoma.
Topics: Animals; Arginine; Blood Circulation; Blood Flow Velocity; Calcium Channel Blockers; Disease Models, Animal; Enzyme Inhibitors; Female; Glaucoma; Intraocular Pressure; Lasers, Gas; Macaca fascicularis; NG-Nitroarginine Methyl Ester; Nifedipine; Optic Disk; Piperazines; Regional Blood Flow; Tonometry, Ocular; Trabecular Meshwork | 2012 |
Histological protection by nilvadipine against neurotoxicity induced by NOC12, a nitric oxide donor, in the rat retina.
Topics: Animals; Antioxidants; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; Nifedipine; Nitric Oxide Donors; Nitroso Compounds; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Diseases | 2014 |
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Hippocampus; Homocysteine; Hyperhomocysteinemia; Indans; Male; Maze Learning; Memory Disorders; Nerve Tissue Proteins; Nifedipine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Silver Staining; Tacrine | 2014 |
The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation.
Topics: Amyloid beta-Peptides; Animals; Calcium Channel Blockers; Cell Line, Tumor; CHO Cells; Cricetulus; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Intracellular Signaling Peptides and Proteins; Neurons; NF-kappa B; Nifedipine; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Syk Kinase; tau Proteins | 2014 |
Congruent release of drug and polymer: A "sweet spot" in the dissolution of amorphous solid dispersions.
Topics: Chemistry, Pharmaceutical; Dihydropyridines; Drug Carriers; Drug Liberation; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Scanning; Nifedipine; Polymers; Pyrrolidines; Solubility; Vinyl Compounds; X-Ray Microtomography | 2019 |
Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain Concussion; Calcium Channel Blockers; Calcium-Binding Proteins; Glial Fibrillary Acidic Protein; Inflammation; Mice; Microfilament Proteins; Nifedipine; Phosphorylation; Rotarod Performance Test; Spatial Learning; Spatial Memory; Syk Kinase | 2020 |