nifedipine and midazolam

nifedipine has been researched along with midazolam in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.61)	18.7374
1990's	10 (16.13)	18.2507
2000's	23 (37.10)	29.6817
2010's	27 (43.55)	24.3611
2020's	1 (1.61)	2.80

Authors

Authors	Studies
Belas, F; Chaudhary, AK; Cvetkovic, M; Dempsey, PJ; Fromm, MF; Kim, RB; Leake, B; Roden, DM; Roden, MM; Wandel, C; Wilkinson, GR; Wood, AJ	1
Topliss, JG; Yoshida, F	1
Katoh, M; Nakajima, M; Yamazaki, H; Yokoi, T	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Bonomo, F; Motta, P; Pagliarusco, S; Pellegatti, M; Pons, N	1
Bass, JY; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Madauss, KP; Marr, HB; McFadyen, RB; Miller, AB; Mills, WY; Navas, F; Parks, DJ; Smalley, TL; Spearing, PK; Todd, D; Williams, SP; Wisely, GB	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chan, KH; Hseu, SS; Lee, TY; Lui, PW	1
Hertz, L; Stolzenburg, JU; Subbarao, KV	1
Ring, BJ; Wrighton, SA	1
Watkins, PB	1
Code, WE; Hertz, L; Zhao, Z	1
Laufen, H; Scharpf, F; Yeates, RA; Zimmermann, T	1
Kanmura, Y; Yamaguchi, S; Yoshimura, N	1
Asahi, S; Gillam, EM; Guengerich, FP; Nakajima, M; Nakamura, M; Shimada, N; Shimada, T; Yamazaki, H; Yokoi, T	1
Crespi, CL; Davitt, CM; Hu, M; Huang, SM; Li, Y; Penman, BW; Thummel, K	1
Atkins, WM; Liu, N; Lu, AY; Newton, DJ; Wang, RW	1
Blanchard, AP; Crespi, CL; Dandeneau, AA; Erve, JC; Miller, VP; Stresser, DM; Turner, SD	1
Emoto, C; Iketaki, H; Nakajima, M; Satoh, T; Shimada, N; Shimizu, R; Suzuki, S; Yamasaki, S; Yamazaki, H; Yokoi, T	1
Cantrell, VE; Eckstein, J; Hall, SD; Hamman, MA; Jones, DR; Ring, BJ; Ruterbories, K; Williams, JA; Wrighton, SA	1
Blain, PG; Daly, AK; Leathart, JB; Mutch, E; Williams, FM	1
Greenblatt, DJ; Patki, KC; Von Moltke, LL	1
Clarke, SE; Galetin, A; Houston, JB	1
Cook, CS; Fitzloff, JF; Shen, L	1
Galetin, A; Hallifax, D; Houston, JB; Ito, K	1
Booth-Genthe, C; Carr, B; Fang, Y; Lu, P; Norcross, R; Rodrigues, AD; Rushmore, T; Shou, M	1
Nakamura, K; Okazaki, O; Okudaira, N; Sudo, K; Watanabe, A	1
Fujita, Y; Guengerich, FP; Horiuchi, R; Miyazaki, M; Nakamura, K; Yamamoto, K	1
Fukuzaki, K; Kohara, S; Matsushita, A; Murayama, N; Nagata, R; Osada, N; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H	1
Foti, RS; Rock, DA; Wahlstrom, JL; Wienkers, LC	1
Aoki, M; Haga, M; Hayashi, M; Nishigaki, R; Okudaira, K	1
Adams, LM; Fernandes, SA; Fina, P; Fiore, M; Johnson, BM; Pagliarusco, S; Peroni, M; Zamuner, S	1
Court, MH; Duan, SX; Greenblatt, DJ; Harmatz, JS; Parent, SJ; Venkatakrishnan, K; von Moltke, LL; Zhao, Y	1
Hayashi, M; Shou, M; Skiles, GL; Xu, Y; Zhou, Y	1
Ali Khan, MA; Hasan, N; Sabir, MS	1
Aiba, T; Kajikawa, N; Kawasaki, H; Kurosaki, Y; Kusaba, J	1
Annes, WF; Ayan-Oshodi, MA; Brown, T; de la Peña, A; Friedrich, S; Hall, SD; Lowe, SL; Willis, BA; Wise, SD; Zhang, W	1
Cao, Y; Ge, G; Hong, JY; Liu, Y; Wu, J; Yang, L; Zhang, Y; Zhu, L	1
Baneyx, G; Iliadis, A; Lavé, T; Meille, C; Parrott, N	1
Ishigai, M; Kato, M; Mitsui, T; Miyake, T; Nagao, S; Nemoto, T; Ogawa, K; Yamada, H	1
Kosugi, Y; Takahashi, J	1
Lee, E; Liu, KH; Shon, JC	1
Inoue, T; Ishii, S; Nakanishi, K; Sasaki, E; Uehara, S; Uno, Y; Yamazaki, H	1
Cao, YF; Fang, ZZ; Gonzalez, FJ; Liu, YZ; Sun, HZ; Sun, T; Wu, JJ; Yang, K; Yin, J; Zhao, J; Zhu, ZT	1
Akiyoshi, T; Imaoka, A; Ishikawa, Y; Ohtani, H	1
Coboeken, K; Dallmann, A; Eissing, T; Hempel, G; Ince, I	1
Kondo, S; Miyake, M	1
Morikuni, S; Murayama, N; Noda, Y; Uno, Y; Yamazaki, H	1

Reviews

2 review(s) available for nifedipine and midazolam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Noninvasive tests of CYP3A enzymes. Pharmacogenetics, 1994, Volume: 4, Issue:4 Topics: Animals; Breath Tests; Cytochrome P-450 Enzyme System; Dapsone; Erythromycin; Humans; Hydrocortisone; Lidocaine; Liver; Midazolam; Nifedipine	1994

Trials

3 trial(s) available for nifedipine and midazolam

Article	Year
Midazolam as an induction agent for thoracotomy in comparison with diazepam with or without nifedipine. Ma zui xue za zhi = Anaesthesiologica Sinica, 1988, Volume: 26, Issue:2 Topics: Adult; Aged; Anesthetics; Clinical Trials as Topic; Diazepam; Female; Humans; Male; Midazolam; Middle Aged; Nifedipine; Preanesthetic Medication; Random Allocation; Thoracotomy	1988
Screening for cytochrome P450 3A in man: studies with midazolam and nifedipine. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:9 Topics: Adult; Area Under Curve; Biotransformation; Calcium Channel Blockers; Chromatography, Gas; Cytochrome P-450 CYP2E1; Female; GABA Modulators; Humans; Male; Midazolam; Middle Aged; Nifedipine	1996
The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor, ketoconazole. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:10 Topics: Administration, Oral; Adult; Aged; Alanine; Amyloid Precursor Protein Secretases; Area Under Curve; Azepines; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Half-Life; Hepatocytes; Humans; Hydroxylation; Ketoconazole; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Models, Biological; Nifedipine; Testosterone; Young Adult	2012

Other Studies

57 other study(ies) available for nifedipine and midazolam

Article	Year
Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharmaceutical research, 1999, Volume: 16, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Male; Mice; Oxidoreductases, N-Demethylating; Pharmacokinetics; Substrate Specificity	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2001, Volume: 12, Issue:4 Topics: Amiodarone; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Daunorubicin; Digoxin; Enzyme Inhibitors; GABA Modulators; Gonadal Steroid Hormones; Humans; LLC-PK1 Cells; Midazolam; Mixed Function Oxygenases; Nifedipine; Phthalazines; Swine; Testosterone	2001
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results	2006
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Adult; Cells, Cultured; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Middle Aged; Models, Molecular; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperazines; Piperidines; Recombinant Proteins; Young Adult	2011
Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorganic & medicinal chemistry letters, 2011, Feb-15, Volume: 21, Issue:4 Topics: Animals; Binding Sites; Blood Glucose; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Dogs; Fluorescence Resonance Energy Transfer; Humans; Isoxazoles; Ligands; Mice; Molecular Conformation; Naphthalenes; Protein Structure, Tertiary; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Weight Gain	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump. Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index	2014
Pharmacological characteristics of potassium-induced, glycogenolysis in astrocytes. Neuroscience letters, 1995, Aug-18, Volume: 196, Issue:1-2 Topics: Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Glycogen; Mice; Mice, Inbred Strains; Midazolam; Nifedipine; Potassium; Time Factors	1995
Grapefruit juice interactions with drugs. The Medical letter on drugs and therapeutics, 1995, Aug-18, Volume: 37, Issue:955 Topics: Beverages; Caffeine; Citrus; Cyclosporine; Estrogens; Felodipine; Food-Drug Interactions; Humans; Midazolam; Nifedipine; Terfenadine	1995
Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine. Pharmaceutical research, 1994, Volume: 11, Issue:6 Topics: Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Nizatidine	1994
Effects of benzodiazepines on potassium-induced increase in free cytosolic calcium concentration in astrocytes: interactions with nifedipine and the peripheral-type benzodiazepine antagonist PK 11195. Canadian journal of physiology and pharmacology, 1996, Volume: 74, Issue:3 Topics: Animals; Anti-Anxiety Agents; Astrocytes; Calcium; Calcium Channel Blockers; Cytosol; Diazepam; Drug Interactions; Isoquinolines; Membrane Potentials; Mice; Mice, Inbred Strains; Midazolam; Nifedipine; Potassium	1996
Effects of midazolam on contractions in smooth muscle of the rabbit mesenteric artery. Anesthesia and analgesia, 1997, Volume: 84, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthetics, Intravenous; Animals; Caffeine; Calcium Channel Blockers; Dose-Response Relationship, Drug; Hypnotics and Sedatives; In Vitro Techniques; Male; Mesenteric Arteries; Midazolam; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits	1997
Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:9 Topics: Anesthetics, Intravenous; Bacteria; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Escherichia coli; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Membranes; Midazolam; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Nifedipine; Oxidation-Reduction; Recombinant Proteins; Testosterone	1999
Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase. Pharmaceutical research, 1999, Volume: 16, Issue:9 Topics: Anticoagulants; Antineoplastic Agents, Hormonal; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Carcinogens; Cell Division; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diuretics, Osmotic; GABA Modulators; Gene Expression Regulation, Enzymologic; Genetic Vectors; Humans; Indoles; Mammary Tumor Virus, Mouse; Mannitol; Microscopy, Electron; Microsomes; Midazolam; Mixed Function Oxygenases; Nifedipine; Oxidoreductases; Propranolol; Pyridines; Sympatholytics; Testosterone; Tetradecanoylphorbol Acetate; Transfection; Tritium; Warfarin	1999
Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:3 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hydroxylation; Kinetics; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Nifedipine; Recombinant Proteins; Substrate Specificity; Terfenadine; Testosterone	2000
Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:12 Topics: Algorithms; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluorescent Dyes; GABA Modulators; Humans; In Vitro Techniques; Kinetics; Mass Spectrometry; Midazolam; Mixed Function Oxygenases; Nifedipine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Testosterone	2000
Cooperativity of alpha-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:5 Topics: Animals; Benzoflavones; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; GABA Modulators; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Inhibitory Concentration 50; Intestines; Kinetics; Mice; Microsomes; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Nifedipine; Oxygen; Protein Binding; Steroid Hydroxylases; Terfenadine; Testosterone; Vasodilator Agents	2001
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:8 Topics: Alprazolam; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clarithromycin; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Diltiazem; Estradiol; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Midazolam; Nifedipine; Tamoxifen; Testosterone; Triazolam	2002
Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man? Archives of toxicology, 2003, Volume: 77, Issue:6 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Insecta; Mephenytoin; Microsomes, Liver; Midazolam; NADP; Nifedipine; Nitrophenols; Paclitaxel; Paraoxon; Parathion; Testosterone	2003
In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Recombinant Proteins; Testosterone; Triazolam	2003
Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:9 Topics: Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Felodipine; Humans; Kinetics; Midazolam; Models, Biological; Nifedipine; Substrate Specificity; Testosterone; Tumor Cells, Cultured	2003
Differential enantioselectivity and product-dependent activation and inhibition in metabolism of verapamil by human CYP3As. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Calcium Channel Blockers; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; In Vitro Techniques; Kinetics; Mass Spectrometry; Microsomes, Liver; Midazolam; Nifedipine; Oxidoreductases, N-Demethylating; Stereoisomerism; Testosterone; Verapamil	2004
CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1 Topics: Algorithms; Anti-Arrhythmia Agents; Area Under Curve; Azoles; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Forecasting; Humans; Hypnotics and Sedatives; In Vitro Techniques; Kinetics; Microsomes; Midazolam; Nifedipine; Quinidine; Substrate Specificity; Testosterone	2005
Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:10 Topics: Amino Acid Sequence; Animals; Baculoviridae; Base Sequence; Blotting, Western; Cell Line; Cloning, Molecular; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Ketoconazole; Kinetics; Liver; Macaca mulatta; Microsomes, Liver; Midazolam; Molecular Sequence Data; Nifedipine; Recombinant Proteins; Sequence Analysis, DNA; Spodoptera; Substrate Specificity; Testosterone	2006
Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7 Topics: Animals; Automation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Midazolam; Models, Biological; Molecular Structure; Nifedipine; Protein Binding; Reproducibility of Results; Risk Assessment; Structure-Activity Relationship; Testosterone	2007
Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:11 Topics: Alleles; Catalysis; Cytochrome P-450 CYP3A; Enzyme Activation; Humans; Isoenzymes; Microsomes, Liver; Midazolam; Nifedipine; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity; Testosterone	2008
Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:2 Topics: Animals; Asia, Southeastern; China; Cytochrome P-450 CYP3A; DNA; Genetic Variation; Humans; Introns; Isoenzymes; Macaca fascicularis; Macaca mulatta; Midazolam; Nifedipine; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA	2010
Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:6 Topics: Algorithms; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Microsomes, Liver; Midazolam; Molecular Structure; Nifedipine; Quinidine; Substrate Specificity; Testosterone	2010
Contribution of rat pulmonary metabolism to the elimination of lidocaine, midazolam, and nifedipine. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:7 Topics: Animals; Drug Administration Routes; Drug Evaluation, Preclinical; Forecasting; In Vitro Techniques; Lidocaine; Lung; Male; Microsomes; Microsomes, Liver; Midazolam; Nifedipine; Rats; Rats, Wistar	2010
Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP450 3A4 substrates midazolam and nifedipine. British journal of clinical pharmacology, 2010, Volume: 70, Issue:4 Topics: Adult; Calcium Channel Blockers; Cohort Studies; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Neurokinin-1 Receptor Antagonists; Nifedipine; Piperazines; Piperidines; Young Adult	2010
Mechanism of cytochrome P450-3A inhibition by ketoconazole. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:2 Topics: Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Male; Microsomes, Liver; Midazolam; Middle Aged; Nifedipine; Testosterone; Triazolam; Young Adult	2011
Simulation of clinical drug-drug interactions from hepatocyte CYP3A4 induction data and its potential utility in trial designs. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Area Under Curve; Carbamazepine; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Midazolam; Nifedipine; Phenobarbital; Rifampin; Simvastatin; Substrate Specificity	2011
Hypertensive encephalopathy: a rare presentation of Williams-Beuren Syndrome. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2011, Volume: 21, Issue:8 Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Child, Preschool; Diuretics; Enalapril; Furosemide; GABA Modulators; Humans; Hypertensive Encephalopathy; Male; Midazolam; Nifedipine; Williams Syndrome	2011
Comparative study on altered hepatic metabolism of CYP3A substrates in rats with glycerol-induced acute renal failure. Biopharmaceutics & drug disposition, 2012, Volume: 33, Issue:1 Topics: Acute Kidney Injury; Animals; Cytochrome P-450 CYP3A; Glycerol; Male; Microsomes, Liver; Midazolam; Nifedipine; Rats; Rats, Wistar; Rifabutin	2012
Deoxyschizandrin, a naturally occurring lignan, is a specific probe substrate of human cytochrome P450 3A. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:1 Topics: Animals; Biotransformation; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Kinetics; Lignans; Male; Microsomes, Liver; Midazolam; Nifedipine; Oxidation-Reduction; Polycyclic Compounds; Rats; Rats, Wistar; Testosterone	2014
Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: influence of time between substrate and inducer administration. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Jun-02, Volume: 56 Topics: Alfentanil; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Hepatocytes; Humans; Midazolam; Models, Biological; Nifedipine; Rifampin; Tissue Distribution; Triazolam	2014
A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:9 Topics: Alprazolam; Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Humans; Male; Mice; Mice, Transgenic; Microsomes, Liver; Midazolam; Nifedipine; Nitrendipine; Quinidine	2014
Species differences and substrate specificity of CYP3A heteroactivation by efavirenz. Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:4 Topics: Administration, Oral; Alkynes; Animals; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP3A; Drug Interactions; Haplorhini; Humans; Hydroxylation; Male; Microsomes, Liver; Midazolam; Nifedipine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Species Specificity; Substrate Specificity; Testosterone	2015
Simultaneous evaluation of substrate-dependent CYP3A inhibition using a CYP3A probe substrates cocktail. Biopharmaceutics & drug disposition, 2016, Volume: 37, Issue:6 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Discovery; Drug Interactions; Humans; Microsomes, Liver; Midazolam; Nifedipine; Substrate Specificity; Testosterone	2016
Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:5 Topics: Adolescent; Adult; Aged; Alprazolam; Animals; Callithrix; Cytochrome P-450 CYP3A; Female; Humans; Intestine, Small; Liver; Macaca fascicularis; Male; Microsomes; Midazolam; Middle Aged; Multigene Family; Nifedipine; Pharmaceutical Preparations; Phylogeny; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Testosterone; Young Adult	2017
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis. Fitoterapia, 2017, Volume: 119 Topics: Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Herb-Drug Interactions; Humans; Hydroxylation; Lignans; Midazolam; Molecular Structure; Nifedipine; Oxidation-Reduction; Schisandra; Testosterone	2017
Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin. Biopharmaceutics & drug disposition, 2017, Volume: 38, Issue:7 Topics: Anti-Bacterial Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Erythromycin; Kinetics; Midazolam; Nifedipine; Testosterone	2017
A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways. Clinical pharmacokinetics, 2018, Volume: 57, Issue:6 Topics: Caffeine; Cytochrome P-450 Enzyme System; Diazepam; Female; Granisetron; Humans; Metoprolol; Metronidazole; Midazolam; Models, Biological; Nifedipine; Ondansetron; Pharmaceutical Preparations; Pregnancy	2018
Simultaneous Prediction of Intestinal Absorption and Metabolism Using the Mini-Ussing Chamber System. Journal of pharmaceutical sciences, 2019, Volume: 108, Issue:1 Topics: Animals; Drug Delivery Systems; Intestinal Absorption; Intestinal Mucosa; Ketoconazole; Male; Midazolam; Nifedipine; Permeability; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley	2019
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs. Xenobiotica; the fate of foreign compounds in biological systems, 2023, Volume: 53, Issue:3 Topics: Alprazolam; Animals; Cytochrome P-450 CYP3A; Dogs; Estradiol; Hydroxylation; Liver; Microsomes, Liver; Midazolam; Nifedipine; Rats; RNA, Messenger	2023