nifedipine and methyldopa

nifedipine has been researched along with methyldopa in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (28.38)	18.7374
1990's	5 (6.76)	18.2507
2000's	15 (20.27)	29.6817
2010's	23 (31.08)	24.3611
2020's	10 (13.51)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Arakaki, Y; Nakamura, N; Takaesu, N	1
Babaian, AS; Dzhandzhapanian, AZ; Gurgenian, SV; Mikaelian, ES	1
Ram, CV	1
Deschamps de Paillette, E; Grimberg, D; Tarrade, T	1
Cerný, J; Dolezel, S; Dostál, M; Guba, P; Petrzilka, J; Sotolová, O; Urbánek, P; Vasků, A; Vasků, J	1
Cerný, J; Dostál, M; Gregor, Z; Guba, P; Rebícek, J; Sotolová, O; Urbánek, P; Vasků, A; Vasků, J	1
Robinson, BF	1
Naden, RP; Redman, CW	1
Janssens, M; Symoens, J	1
Cámera, MI; Martinotti, A; Mayorga, LM; Vignolo, CA; Waisman, GD	1
Beevers, DG; Constantine, G; Luesley, DM; Reynolds, AL	1
Heckmann, U; Ottens, E; Zidek, W	1
Guillén Llera, F; Reuss, JM; Tobares, N; Torres, M; Viguera, S	1
Conway, J	1
Marxer, A; Schier, O	1
Eliahou, HE; Iaina, A	1
Hallbäck-Nordlander, MI; Lundin, SA	1
Day, TW; Mendoza, F	1
Matsui, S; Murakami, E; Murakami, H; Takekoshi, N	1
Bayley, S; Dobbs, RJ; Robinson, BF	1
Guazzi, M	1
Chatani, T; Emoto, J; Fujita, S; Hashimoto, A; Masuya, K; Matsui, S; Murakami, E; Murakami, H; Nomura, M; Takekoshi, N; Tsugawa, H; Tsuji, S	1
Bartorelli, A; Fiorentini, C; Guazzi, MD; Necchi, G; Olivari, MT; Polese, A	1
Jayawardana, J; Lekamge, N	1
Chandran, R; Kyle, PM; Redman, CW; Serra-Serra, V	1
Hall, DR; Odendaal, HJ	1
Grové, D; Hall, DR; Odendaal, HJ; Steyn, DW	1
Grové, D; Hall, DR; Kirsten, GF; Odendaal, HJ; Smith, J	1
Candy, G; Libhaber, E; Radevski, I; Sareli, P; Skudicky, D; Staessen, JA; Thijs, L; Tshele, E; Valtchanova, Z; Wang, JG	1
Okoro, EO; Oyejola, BA	2
de Swiet, M; Goulis, DG; Redman, CW; Walker, IA; Williamson, C	1
Dennedy, MC; Houlihan, DD; Morrison, JJ; Ravikumar, N	1
Chen, SC; Lee, TH; Li, CY; Shibuya, T; Shih, HC	1
Gembruch, U; Merz, WM	1
Dalmia, S; Deka, D; Gupta, N; Mittal, S	1
Monostory, K; Ozsvár, Z; Solymossi, Z	1
Folic, MD; Folic, MM; Jankovic, SM; Varjacic, MR	1
Carvajal-Valencia, JA; Chacón-Solís, AR; Estrada-Altamirano, A; Hernández-Pacheco, JA; Maya-Quiñones, JL; Valenzuela-Jirón, A	1
Alexander, JM; Wilson, KL	1
Arulkumaran, N; Lightstone, L	1
Cosmi, E; D'Antona, D; Gizzo, S; Noventa, M; Paccagnella, G; Patrelli, TS; Saccardi, C	1
Brussé, IA; Duvekot, JJ; Grune, F; Sonneveld, MJ; Steegers, EA; Visser, GH	1
Firoz, T; Gordon, R; MacDonell, K; Magee, LA; Payne, BA; Vidler, M; von Dadelszen, P	1
Jim, B; Reddy, S	1
Bracken, H; Easterling, T; Magee, LA; Mool, S; Mundle, S; Parvekar, S; Shochet, T; von Dadelszen, P; Winikoff, B	1
Karumanchi, SA; Lemoine, ER	1
Abdallah, S; Gaber, W; Gamal, A; Hamza, H; Marawan, H; Rezk, M; Salama, M	1
Mol, BW; Saade, GR	1
Rezk, M	1
Bellos, I; Daskalakis, G; Loutradis, D; Papapanagiotou, A; Pergialiotis, V	1
Alers, RJ; Cauffman, E; Ghossein-Doha, C; Lopes van Balen, VA; Mulder, EG; Oben, J; Schiffer, VMMM; Smits, L; Spaanderman, MEA; van Kuijk, SMJ	1
Ashworth, D; Battersby, C; Chappell, LC; Cluver, C; Green, M; Hardy, P; McManus, RJ	1
Avalos, LA; Badon, SE; Bider-Canfield, Z; Cheetham, TC; Chen, L; Dublin, S; Easterling, TR; Holt, VL; Idu, A; Nance, N; Neugebauer, RS; Reynolds, K; Shortreed, SM	1
Hirakawa, H; Ito, M; Josaka, R; Kikuchi, D; Miura, R; Obara, T; Okada, K; Suzuki, N; Tokunaga, M; Usui, K	1
Allegaert, K; Flint, RB; Mian, P; Schoenmakers, S; van de Vusse, D; Versmissen, J; Visser, W	1
Shigemi, D; Taguchi, R; Yasunaga, H	1
Bhat, AD; Dombrowski, MM; Keasler, PM; Kolluru, L; Palanisamy, A; Singh, PM	1

Reviews

15 review(s) available for nifedipine and methyldopa

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Calcium antagonists in the treatment of hypertension. The American journal of the medical sciences, 1985, Volume: 290, Issue:3 Topics: Biological Transport, Active; Calcium; Calcium Channel Blockers; Captopril; Diltiazem; Diuretics; Drug Resistance; Drug Therapy, Combination; Electrophysiology; Humans; Hypertension; Hypertension, Renovascular; Ion Channels; Kinetics; Methyldopa; Muscle, Smooth, Vascular; Nifedipine; Propranolol; Sodium; Vascular Resistance; Verapamil	1985
Calcium-entry blocking agents in the treatment of systemic hypertension. The American journal of cardiology, 1985, Jan-25, Volume: 55, Issue:3 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Methyldopa; Nifedipine; Renin; Sodium; Verapamil	1985
Antihypertensive drugs in pregnancy. Clinics in perinatology, 1985, Volume: 12, Issue:3 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Female; Fetus; Humans; Hydralazine; Hypertension; Labetalol; Methyldopa; Nifedipine; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Regional Blood Flow; Uterus	1985
Antihypertensive agents 1969-1980. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1981, Volume: 25 Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Clonidine; Ergolines; Fusaric Acid; Guanidines; Humans; Hydralazine; Indoramin; Methyldopa; Minoxidil; Nifedipine; Piperazines; Prazosin; Prostaglandins	1981
From beta blockers to Ca2+ blockers in hypertension: a review. Israel journal of medical sciences, 1982, Volume: 18, Issue:7 Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Circulation; Drug Therapy, Combination; Humans; Hypertension; Hypotension; Methyldopa; Nifedipine; Vascular Resistance; Verapamil	1982
Pharmacologic management of Raynaud's phenomenon. Southern medical journal, 1984, Volume: 77, Issue:9 Topics: Blood Platelets; Blood Viscosity; Fibrinogen; Griseofulvin; Humans; Methyldopa; Nifedipine; Parasympatholytics; Phenoxybenzamine; Raynaud Disease; Receptors, Adrenergic; Reserpine	1984
Hypertensive emergencies of pregnancy. Obstetrics and gynecology clinics of North America, 2013, Volume: 40, Issue:1 Topics: Antihypertensive Agents; Calcium Channel Blockers; Creatine; Diuretics; Emergency Medicine; Female; Fetal Monitoring; Humans; Hydralazine; Infusions, Intravenous; Labetalol; Methyldopa; Nifedipine; Nitroprusside; North America; Oliguria; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Proteinuria	2013
Severe pre-eclampsia and hypertensive crises. Best practice & research. Clinical obstetrics & gynaecology, 2013, Volume: 27, Issue:6 Topics: Administration, Intravenous; Administration, Oral; Antihypertensive Agents; Critical Care; Early Diagnosis; Eclampsia; Female; HELLP Syndrome; Humans; Hydralazine; Hypertension, Pregnancy-Induced; Labetalol; Magnesium Sulfate; Methyldopa; Nifedipine; Nitroglycerin; Pre-Eclampsia; Pregnancy; Risk Assessment; Risk Factors; Severity of Illness Index; Treatment Outcome; United Kingdom	2013
Twin pregnancy after kidney transplantation: what's on? A case report and review of literature. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:17 Topics: Adult; Anemia; Female; Humans; Hypertension, Pregnancy-Induced; Iron; Kidney Transplantation; Methyldopa; Nifedipine; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy, Twin; Transplant Recipients	2014
Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review. BJOG : an international journal of obstetrics and gynaecology, 2014, Volume: 121, Issue:10 Topics: Administration, Oral; Antihypertensive Agents; Female; Humans; Hydralazine; Hypertension, Pregnancy-Induced; Labetalol; Methyldopa; Nifedipine; Postpartum Period; Pregnancy; Pregnancy Complications, Cardiovascular; Randomized Controlled Trials as Topic; Treatment Outcome; Vasodilator Agents	2014
Hypertension and Pregnancy: Management and Future Risks. Advances in chronic kidney disease, 2019, Volume: 26, Issue:2 Topics: Antihypertensive Agents; Aspirin; Cardiovascular Diseases; Chronic Disease; Diuretics; Female; Humans; Hypertension; Hypertension, Pregnancy-Induced; Labetalol; Methyldopa; Nifedipine; Platelet Aggregation Inhibitors; Pre-Eclampsia; Preconception Care; Pregnancy; Pregnancy Complications, Cardiovascular; Prenatal Care; Renal Insufficiency, Chronic; Risk Factors; Vasodilator Agents	2019
Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:4 Topics: Abruptio Placentae; Amlodipine; Antihypertensive Agents; Atenolol; Cesarean Section; Chronic Disease; Female; Fetal Growth Retardation; Furosemide; Gestational Age; Humans; Hypertension; Incidence; Infant, Small for Gestational Age; Ketanserin; Methyldopa; Network Meta-Analysis; Nifedipine; Perinatal Death; Pindolol; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Premature Birth; Severity of Illness Index	2020
Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review. European journal of clinical pharmacology, 2022, Volume: 78, Issue:11 Topics: Antihypertensive Agents; Female; Humans; Hypertension; Hypertension, Pregnancy-Induced; Labetalol; Methyldopa; Nifedipine; Pregnancy; Pregnancy Complications, Cardiovascular	2022
Treatment of acute-onset hypertension in pregnancy: A network meta-analysis of randomized controlled trials comparing anti-hypertensives and route of administration. Pregnancy hypertension, 2023, Volume: 34 Topics: Antihypertensive Agents; Calcium Channel Blockers; Female; Humans; Hydralazine; Hypertension; Infant, Newborn; Ketanserin; Methyldopa; Network Meta-Analysis; Nifedipine; Pre-Eclampsia; Pregnancy; Randomized Controlled Trials as Topic	2023

Trials

11 trial(s) available for nifedipine and methyldopa

Article	Year
[Cicletanine administered with other antihypertensive agents]. Archives des maladies du coeur et des vaisseaux, 1989, Volume: 82 Spec No 4 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Diuretics; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Nifedipine; Pyridines	1989
Ketanserin compared to nifedipine and methyldopa in patients aged above 50 years: two international multicentre studies. For the International Study Group. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1986, Volume: 4, Issue:6 Topics: Blood Pressure; Body Weight; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Ketanserin; Male; Methyldopa; Middle Aged; Nifedipine	1986
[Effectiveness and tolerance of slow-release nifedipine in the treatment of moderate arterial hypertension in the elderly. A comparative multicenter study]. Revista clinica espanola, 1986, Volume: 179, Issue:9 Topics: Aged; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Hypertension; Male; Methyldopa; Nifedipine	1986
Third-line therapy. A cautionary note. Clinical and experimental hypertension. Part A, Theory and practice, 1985, Volume: 7, Issue:10 Topics: Atenolol; Bendroflumethiazide; Captopril; Chlorthalidone; Female; Humans; Hypertension; Male; Methyldopa; Nifedipine	1985
Nifedipine in the treatment of hypertension: report of a double-blind controlled trial. British journal of clinical pharmacology, 1982, Volume: 14, Issue:4 Topics: Adult; Aged; Clinical Trials as Topic; Delayed-Action Preparations; Diuretics; Double-Blind Method; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Nifedipine; Pyridines	1982
Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension. Circulation, 1980, Volume: 61, Issue:5 Topics: Drug Therapy, Combination; Edema; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Methyldopa; Middle Aged; Nifedipine; Posture; Pyridines	1980
A comparison of nifedipine with methyldopa in pregnancy induced hypertension. The Ceylon medical journal, 1994, Volume: 39, Issue:2 Topics: Adult; Female; Humans; Hypertension; Methyldopa; Nifedipine; Pregnancy; Pregnancy Complications, Cardiovascular; Prospective Studies	1994
The addition of a diuretic to anti-hypertensive therapy for early severe hypertension in pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1998, Volume: 60, Issue:1 Topics: Adult; Amiloride; Antihypertensive Agents; Diuretics; Drug Combinations; Drug Therapy, Combination; Female; Gestational Age; Humans; Hydrochlorothiazide; Hypertension; Length of Stay; Methyldopa; Nifedipine; Prazosin; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Treatment Outcome	1998
Relationship between treatment-induced changes in left ventricular mass and blood pressure in black african hypertensive patients: results of the Baragwanath Trial. Circulation, 2002, Feb-19, Volume: 105, Issue:7 Topics: Angiotensin-Converting Enzyme Inhibitors; Black People; Blood Pressure; Body Mass Index; Calcium Channel Blockers; Diastole; Diuretics; Echocardiography; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Male; Methyldopa; Middle Aged; Nifedipine; Patient Compliance; Regression Analysis; South Africa; Systole; Verapamil	2002
Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial. Lancet (London, England), 2019, Sep-21, Volume: 394, Issue:10203 Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension, Pregnancy-Induced; India; Infant, Newborn; Labetalol; Methyldopa; Nifedipine; Pregnancy; Pregnancy Outcome; Treatment Outcome; Young Adult	2019
Methyldopa versus nifedipine or no medication for treatment of chronic hypertension during pregnancy: A multicenter randomized clinical trial. Pregnancy hypertension, 2019, Volume: 17 Topics: Administration, Oral; Adult; Antihypertensive Agents; Egypt; Female; Humans; Hypertension; Hypertension, Pregnancy-Induced; Infant, Newborn; Methyldopa; Nifedipine; Pregnancy; Pregnancy Complications, Cardiovascular; Prenatal Diagnosis; Treatment Outcome; Young Adult	2019

Other Studies

48 other study(ies) available for nifedipine and methyldopa

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Priapism in haemodialysis patient due to prazosin? British journal of urology, 1991, Volume: 68, Issue:5 Topics: Adult; Drug Therapy, Combination; Heparin; Humans; Hypertension; Male; Methyldopa; Nifedipine; Prazosin; Priapism; Renal Dialysis	1991
Efficacy of intravenous verapamil in arterial hypertension refractory to three-step antihypertensive therapy. Cor et vasa, 1991, Volume: 33, Issue:5 Topics: Adult; Antihypertensive Agents; Clonidine; Echocardiography; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Hypertension, Renal; Infusions, Intravenous; Male; Methyldopa; Middle Aged; Nifedipine; Ventricular Function, Left; Verapamil	1991
Therapy of venous hypertension in calves with total artificial heart (TAH). The International journal of artificial organs, 1989, Volume: 12, Issue:4 Topics: Animals; Antihypertensive Agents; Captopril; Cardiac Pacing, Artificial; Cattle; Central Venous Pressure; Clonidine; Heart, Artificial; Hypertension; Liver Function Tests; Methyldopa; Nifedipine; Postoperative Complications; Prazosin	1989
[Therapy of venous hypertension in animals with an artificial heart and long-term survival]. Casopis lekaru ceskych, 1989, Sep-01, Volume: 128, Issue:36 Topics: Animals; Antihypertensive Agents; Captopril; Cattle; Clonidine; Diltiazem; Heart, Artificial; Methyldopa; Nifedipine; Prazosin; Venous Pressure	1989
Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia? American journal of obstetrics and gynecology, 1988, Volume: 159, Issue:2 Topics: Adult; Drug Synergism; Female; Humans; Hypertension; Magnesium Sulfate; Methyldopa; Nifedipine; Pre-Eclampsia; Pregnancy	1988
Nifedipine as a second line antihypertensive drug in pregnancy. British journal of obstetrics and gynaecology, 1987, Volume: 94, Issue:12 Topics: Adult; Atenolol; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Hypertension; Methyldopa; Nifedipine; Pregnancy; Pregnancy Complications, Cardiovascular	1987
The effect of antihypertensive treatment on the circulating hypertensive factor in the spontaneously hypertensive rat. Clinical and experimental hypertension. Part A, Theory and practice, 1987, Volume: 9, Issue:12 Topics: Animals; Antihypertensive Agents; Cross Circulation; Furosemide; Hypertension; Male; Methyldopa; Nifedipine; Propranolol; Rats; Rats, Inbred SHR	1987
Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats. Journal of hypertension, 1984, Volume: 2, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cardiovascular System; Circadian Rhythm; Felodipine; Heart Rate; Hypertension; Methyldopa; Metoprolol; Nifedipine; Rats; Rats, Inbred SHR; Time Factors	1984
Nifedipine in hypertension and heart failure. Clinical therapeutics, 1984, Volume: 6, Issue:2 Topics: Adult; Aged; Blood Pressure; Delayed-Action Preparations; Drug Therapy, Combination; Female; Heart Failure; Heart Rate; Humans; Hypertension; Isosorbide Dinitrate; Male; Methyldopa; Middle Aged; Myocardial Infarction; Nifedipine; Propranolol; Renin-Angiotensin System	1984
[Nifedipine in the treatment of hypertension]. Revista espanola de cardiologia, 1982, Volume: 35, Issue:5 Suppl 2 Topics: Calcium Channel Blockers; Drug Therapy, Combination; Humans; Hypertension; Methyldopa; Muscle, Smooth, Vascular; Nifedipine; Pyridines	1982
Treatment of severe hypertension and hypertensive emergency with nifedipine, a calcium antagonistic agent. Japanese circulation journal, 1981, Volume: 45, Issue:7 Topics: Administration, Oral; Adult; Aged; Calcium; Drug Synergism; Drug Therapy, Combination; Emergencies; Enema; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Nifedipine; Propranolol; Pyridines	1981
The effect of nifedipine and methyldopa on maternal cerebral circulation. British journal of obstetrics and gynaecology, 1997, Volume: 104, Issue:5 Topics: Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Cerebral Arteries; Cerebrovascular Circulation; Female; Heart Rate; Humans; Hypertension; Methyldopa; Nifedipine; Pregnancy; Pregnancy Complications, Cardiovascular; Prospective Studies; Ultrasonography, Interventional; Vasodilator Agents	1997
Expectant management of early onset, severe pre-eclampsia: maternal outcome. BJOG : an international journal of obstetrics and gynaecology, 2000, Volume: 107, Issue:10 Topics: Adolescent; Adult; Antihypertensive Agents; Calcium Channel Blockers; Dihydralazine; Female; Fetal Distress; Humans; Magnesium Sulfate; Methyldopa; Monitoring, Physiologic; Nifedipine; Prazosin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prospective Studies	2000
Expectant management of early onset, severe pre-eclampsia: perinatal outcome. BJOG : an international journal of obstetrics and gynaecology, 2000, Volume: 107, Issue:10 Topics: Antihypertensive Agents; Calcium Channel Blockers; Female; Fetal Monitoring; Humans; Infant Mortality; Infant, Newborn; Intensive Care, Neonatal; Length of Stay; Male; Methyldopa; Multivariate Analysis; Nifedipine; Prazosin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prospective Studies	2000
Inadequate control of blood pressure in Nigerians with diabetes. Ethnicity & disease, 2004,Winter, Volume: 14, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care Facilities; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Body Mass Index; Calcium Channel Blockers; Diabetes Complications; Diabetes Mellitus; Drug Combinations; Drug Therapy, Combination; Humans; Hypertension; Hypoglycemic Agents; Insulin; Male; Methyldopa; Middle Aged; Nifedipine; Nigeria; Patient Compliance; Self Care	2004
Treating high blood pressure in Africans with type 2 diabetes. Ethnicity & disease, 2004,Winter, Volume: 14, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzothiadiazines; Calcium Channel Blockers; Calcium Chloride; Diabetes Mellitus, Type 2; Diuretics; Humans; Hypertension; Methyldopa; Nifedipine; Nigeria; Sodium Chloride Symporter Inhibitors	2004
Preeclampsia with abnormal liver function tests is associated with cholestasis in a subgroup of cases. Hypertension in pregnancy, 2004, Volume: 23, Issue:1 Topics: Adrenergic alpha-Agonists; Adult; Anti-Inflammatory Agents; Bile Acids and Salts; Biomarkers; Blood Platelets; Calcium Channel Blockers; Cholestasis; Dexamethasone; Female; Humans; Liver Function Tests; Maternal Welfare; Methyldopa; Nifedipine; Pre-Eclampsia; Pregnancy; Treatment Outcome; United Kingdom	2004
Anti-hypertensive therapy and the feto-placental circulation: effects on umbilical artery resistance. Journal of perinatal medicine, 2004, Volume: 32, Issue:4 Topics: Adult; Antihypertensive Agents; Dose-Response Relationship, Drug; Female; Fetus; Humans; Hydralazine; Labetalol; Magnesium Sulfate; Methyldopa; Nifedipine; Placenta; Pre-Eclampsia; Pregnancy; Regional Blood Flow; Umbilical Arteries; Vascular Resistance	2004
Anti-hypertension effects of traditional Chinese medicine ju-ling-tang on renal hypertensive rats. The American journal of Chinese medicine, 2005, Volume: 33, Issue:6 Topics: Animals; Antihypertensive Agents; Biopsy; Coronary Vessels; Disease Models, Animal; Drugs, Chinese Herbal; Glomerulosclerosis, Focal Segmental; Hypertension, Renal; Kidney; Male; Methyldopa; Nifedipine; Rats; Rats, Wistar	2005
Severe, early-onset hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome episode with spontaneous remission during pregnancy. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2007, Volume: 20, Issue:8 Topics: Adult; Antihypertensive Agents; Female; Fetal Death; HELLP Syndrome; Humans; Methyldopa; Nifedipine; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Second; Proteinuria; Remission, Spontaneous; Severity of Illness Index; Vasodilator Agents	2007
Successful maternal and fetal outcome in a pregnancy with type V Takayasu's aortoarteritis. Archives of gynecology and obstetrics, 2008, Volume: 277, Issue:2 Topics: Adult; Antihypertensive Agents; Arterial Occlusive Diseases; Calcium Channel Blockers; Diuretics; Female; Furosemide; Humans; Hypertension, Pregnancy-Induced; Infant, Newborn; Live Birth; Male; Methyldopa; Mitral Valve Insufficiency; Nifedipine; Pregnancy; Pregnancy Complications, Cardiovascular; Takayasu Arteritis; Ventricular Dysfunction, Left	2008
[Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver]. Orvosi hetilap, 2010, Mar-14, Volume: 151, Issue:11 Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Administration Schedule; Female; Humans; Hypertension, Pregnancy-Induced; Methyldopa; Nifedipine; Oxidoreductases, N-Demethylating; Pregnancy; Pregnancy Complications, Cardiovascular; Transaminases; Treatment Outcome	2010
Effects of methyldopa and nifedipine on uteroplacental and fetal hemodynamics in gestational hypertension. Hypertension in pregnancy, 2012, Volume: 31, Issue:1 Topics: Adult; Antihypertensive Agents; Female; Hemodynamics; Humans; Hypertension, Pregnancy-Induced; Methyldopa; Nifedipine; Placental Circulation; Pregnancy; Prospective Studies	2012
[Takayasu's arteritis in pregnancy: report seven cases]. Ginecologia y obstetricia de Mexico, 2011, Volume: 79, Issue:3 Topics: Adult; Antihypertensive Agents; Cesarean Section; Female; Fetal Growth Retardation; Follow-Up Studies; Humans; Hypertension, Renovascular; Infant, Newborn; Male; Methyldopa; Mexico; Nifedipine; Pre-Eclampsia; Prednisone; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Radiography; Takayasu Arteritis; Young Adult	2011
Cerebral perfusion pressure in women with preeclampsia is elevated even after treatment of elevated blood pressure. Acta obstetricia et gynecologica Scandinavica, 2014, Volume: 93, Issue:5 Topics: Adult; Antihypertensive Agents; Arterial Pressure; Blood Flow Velocity; Case-Control Studies; Cerebral Arteries; Cerebrum; Female; Humans; Methyldopa; Nifedipine; Pre-Eclampsia; Pregnancy; Regional Blood Flow	2014
Oral regimen management of acute hypertension in pregnancy. Lancet (London, England), 2019, 09-21, Volume: 394, Issue:10203 Topics: Antihypertensive Agents; Female; Humans; Hypertension; Labetalol; Methyldopa; Nifedipine; Pregnancy; Pregnancy Complications, Cardiovascular	2019
Letter to the Editor regarding research integrity. Pregnancy hypertension, 2020, Volume: 19 Topics: Antihypertensive Agents; Female; Humans; Hypertension; Methyldopa; Nifedipine; Pre-Eclampsia; Pregnancy	2020
Reply to letter regarding 'Methyldopa versus Nifedipine or no medication for treatment of chronic hypertension during pregnancy'. Pregnancy hypertension, 2020, Volume: 19 Topics: Antihypertensive Agents; Female; Humans; Hypertension; Methyldopa; Nifedipine; Pre-Eclampsia; Pregnancy	2020
Preventing Recurrent Preeclampsia by Tailored Treatment of Nonphysiologic Hemodynamic Adjustments to Pregnancy. Hypertension (Dallas, Tex. : 1979), 2021, Volume: 77, Issue:6 Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Hemodynamics; Humans; Labetalol; Methyldopa; Nifedipine; Pre-Eclampsia; Pregnancy; Secondary Prevention	2021
Which antihypertensive treatment is better for mild to moderate hypertension in pregnancy? BMJ (Clinical research ed.), 2022, 01-18, Volume: 376 Topics: Antihypertensive Agents; Female; Humans; Hypertension, Pregnancy-Induced; Labetalol; Methyldopa; Nifedipine; Pregnancy; Prenatal Care; Treatment Outcome	2022
Maternal and neonatal outcomes of antihypertensive treatment in pregnancy: A retrospective cohort study. PloS one, 2022, Volume: 17, Issue:5 Topics: Antihypertensive Agents; Birth Weight; Female; Humans; Hypertension, Pregnancy-Induced; Infant; Infant, Newborn; Infant, Newborn, Diseases; Labetalol; Methyldopa; Nifedipine; Pregnancy; Pregnancy Outcome; Premature Birth; Retrospective Studies	2022
Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan. Hypertension research : official journal of the Japanese Society of Hypertension, 2022, Volume: 45, Issue:9 Topics: Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Drug Prescriptions; Female; Hospitals; Humans; Hypertension; Japan; Methyldopa; Nifedipine; Pregnancy; Pregnant Women	2022
Trends in antihypertensive prescription for pregnant women with hypertension and their peripartum outcomes before and after label and guideline revisions in Japan. Hypertension research : official journal of the Japanese Society of Hypertension, 2022, Volume: 45, Issue:11 Topics: Antihypertensive Agents; Cesarean Section; Drug Prescriptions; Female; Humans; Hydralazine; Hypertension; Infant, Newborn; Japan; Methyldopa; Nifedipine; Peripartum Period; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Retrospective Studies	2022