nifedipine and melatonin

nifedipine has been researched along with melatonin in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19904 (13.79)18.7374
1990's6 (20.69)18.2507
2000's9 (31.03)29.6817
2010's10 (34.48)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
de Los Ríos, C; Egea, J; Gálvez, E; García, AG; Iriepa, I; León, R; López, MG; Marco-Contelles, J; Moraleda, I; Romero, A; Samadi, A; Villarroya, M1
Ekins, S; Williams, AJ; Xu, JJ1
Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Briones, AM; Egea, J; León, R; López, MG; Martínez-Revelles, S; Menéndez, JC; Parada, E; Ramos, MT; Sridharan, V; Tenti, G1
Cano-Abad, MF; de los Ríos, C; González-Lafuente, L; Lajarín-Cuesta, R; Martínez-Sanz, FJ; Moreno-Ortega, AJ; Punzón, E1
Araujo de Brito, M; Arranz-Tagarro, JA; Arribas, RL; de Los Ríos, C; Gandía, L; González-Lafuente, L; Lajarín-Cuesta, R; Nanclares, C1
Arribas, RL; de Los Ríos, C; Gandía, L; García-Frutos, EM; Lajarín-Cuesta, R; Nanclares, C1
Arribas, RL; Chabchoub, F; de Los Ríos, C; Demougeot, C; Diez-Iriepa, D; Egea, J; Godyń, J; Głuch-Lutwin, M; Iriepa, I; Ismaili, L; Kiec-Kononowicz, K; Kobrlova, T; Malawska, B; Malek, R; Marco-Contelles, J; Moraleda, I; Mordyl, B; Palomino-Antolin, A; Panek, D; Siwek, A; Soukup, O; Totoson, P1
Oe, H; Satake, N; Shibata, S1
Besharse, JC; Iuvone, PM1
Satake, N; Shibata, S; Takagi, T; Usui, H1
Buzzell, GR; Morton, DJ; Reiter, RJ1
Joubert, WS; Kociszewska, VJ; Meyer, AC; Meyer, BJ; Nieuwenhuis, JJ1
Bégay, V; Bois, P; Collin, JP; Falcón, J; Lenfant, J1
Vanecek, J1
Klein, DC; Vanecek, J1
Koizumi, S; Moriyama, Y; Ogura, A; Yamada, H; Yamaguchi, A1
Flanders, S; Lew, MJ1
Vanecek, J; Zemková, H1
Fogari, R; Lusardi, P; Piazza, E1
Hill, M; Kanchev, L; Kancheva, R; Zofková, I1
Lee, PP; Mei, YA; Pang, SF; Wei, H; Zhang, ZH1
Monnet, FP1
Barakat, M; El-Abhar, HS; El-Denshary, ES; Shaalan, M1
Afeche, SC; Barbosa, R; Cipolla-Neto, J; Scialfa, JH; Simonneaux, V; Terra, IM1
Ghibelli, L; Mengoni, F; Nuccitelli, S; Radogna, F1

Trials

2 trial(s) available for nifedipine and melatonin

ArticleYear
Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:5

    Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Heart Rate; Humans; Hypertension; Male; Melatonin; Middle Aged; Nifedipine

2000
Lack of melatonin response to acute administration of nifedipine and diltiazem in healthy men.
    Physiological research, 2000, Volume: 49 Suppl 1

    Topics: Adult; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Darkness; Diltiazem; Humans; Hydrocortisone; Male; Melatonin; Nifedipine; Prolactin; Time Factors

2000

Other Studies

27 other study(ies) available for nifedipine and melatonin

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Calcium; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytotoxins; Electron Transport Chain Complex Proteins; Electrophorus; Glucose; Hippocampus; Humans; Isomerism; Models, Molecular; Naphthyridines; Neuroprotective Agents; Okadaic Acid; Oligomycins; Oxygen; Peptide Fragments; Protein Binding; Protein Phosphatase 2; Rats; Rotenone; Structure-Activity Relationship

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury.
    Journal of medicinal chemistry, 2014, May-22, Volume: 57, Issue:10

    Topics: Animals; Brain Ischemia; Calcium; Calcium Channels, L-Type; Calcium Signaling; Cell Line, Tumor; Dihydropyridines; Hippocampus; Humans; Models, Molecular; Molecular Docking Simulation; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Inbred WKY; Reperfusion Injury

2014
Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger.
    European journal of medicinal chemistry, 2016, Feb-15, Volume: 109

    Topics: Animals; Calcium; Cattle; Cell Line; Cell Line, Tumor; HeLa Cells; Hippocampus; Humans; Mitochondria; Neuroprotective Agents; Pyridines; Rats; Sodium-Calcium Exchanger; Solubility; Thiazepines

2016
Gramine Derivatives Targeting Ca(2+) Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases.
    Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13

    Topics: Alkaloids; Animals; Calcium Channels; Cattle; Cell Survival; Dose-Response Relationship, Drug; Hippocampus; Humans; Indole Alkaloids; Molecular Structure; Neurodegenerative Diseases; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tumor Cells, Cultured

2016
Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection.
    European journal of medicinal chemistry, 2018, Sep-05, Volume: 157

    Topics: Aza Compounds; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Indoles; Molecular Structure; Neuroprotective Agents; Protein Phosphatase 2; Structure-Activity Relationship; Tumor Cells, Cultured

2018
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H
    Journal of medicinal chemistry, 2019, 12-26, Volume: 62, Issue:24

    Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Cholinesterase Inhibitors; Humans; Memory Disorders; Mice; Neuroblastoma; Neuroprotective Agents; Receptors, Histamine H3; Small Molecule Libraries; Tumor Cells, Cultured; Vasodilator Agents

2019
Vasorelaxing action of melatonin in rat isolated aorta; possible endothelium dependent relaxation.
    General pharmacology, 1991, Volume: 22, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta; Endothelium, Vascular; In Vitro Techniques; Male; Melatonin; Methylene Blue; Methysergide; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Purinones; Rats; Rats, Inbred Strains; Verapamil

1991
Involvement of calcium in the regulation of serotonin N-acetyltransferase in retina.
    Journal of neurochemistry, 1986, Volume: 46, Issue:1

    Topics: Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Calcium; Chickens; Circadian Rhythm; Cobalt; Darkness; Gallopamil; Ion Channels; Magnesium; Melatonin; Nifedipine; Pineal Gland; Rats; Retina; Trifluoperazine; Xenopus laevis

1986
Vasorelaxing action of melatonin in rabbit basilar artery.
    General pharmacology, 1989, Volume: 20, Issue:5

    Topics: Animals; Basilar Artery; In Vitro Techniques; Male; Melatonin; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Potassium Chloride; Rabbits; Serotonin

1989
Swimming-induced suppression of rat pineal melatonin is prevented by pretreatment with calcium channel blockers.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1989, Volume: 190, Issue:1

    Topics: Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Male; Melatonin; Nifedipine; Physical Exertion; Pineal Gland; Rats; Rats, Inbred Strains; Reference Values; Swimming; Verapamil

1989
Dihydropyridine calcium antagonists depress the amplitude of the plasma melatonin cycle in baboons.
    Life sciences, 1986, Oct-27, Volume: 39, Issue:17

    Topics: Animals; Calcium Channel Blockers; Male; Melatonin; Nifedipine; Nisoldipine; Nitrendipine; Papio; Verapamil

1986
Calcium and melatonin production in dissociated trout pineal photoreceptor cells in culture.
    Cell calcium, 1994, Volume: 16, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcitonin; Calcium; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Female; Melatonin; Nifedipine; Photoreceptor Cells; Pineal Gland; Time Factors; Trout; Verapamil

1994
Cellular mechanism of melatonin action in neonatal rat pituitary.
    Neuroendocrinology, 1995, Volume: 61, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Drug Synergism; Enzyme Activation; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Melatonin; Nifedipine; Pituitary Gland; Protein Kinase C; Rats; Rats, Wistar; Second Messenger Systems; Tetradecanoylphorbol Acetate

1995
Mechanism of melatonin signal transduction in the neonatal rat pituitary.
    Neurochemistry international, 1995, Volume: 27, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Animals, Newborn; Calcimycin; Calcium; Colforsin; Cyclic AMP; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Melatonin; Nifedipine; Organ Culture Techniques; Pituitary Gland, Anterior; Rats; Receptors, Cell Surface; Receptors, Melatonin; Signal Transduction

1995
Acetylcholine triggers L-glutamate exocytosis via nicotinic receptors and inhibits melatonin synthesis in rat pinealocytes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jul-01, Volume: 18, Issue:13

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Arylamine N-Acetyltransferase; Atropine; Bungarotoxins; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carbachol; Cells, Cultured; Diltiazem; Exocytosis; Glutamic Acid; Melatonin; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nifedipine; Nitrendipine; Oxotremorine; Parasympathetic Nervous System; Pineal Gland; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Synaptic Vesicles; Tubocurarine

1998
Mechanisms of melatonin-induced vasoconstriction in the rat tail artery: a paradigm of weak vasoconstriction.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Acetamides; Animals; Anticonvulsants; Arteries; Calcium Channel Blockers; Charybdotoxin; Colforsin; Dose-Response Relationship, Drug; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Male; Melatonin; Nifedipine; Nitroprusside; Potassium Channels; Rats; Rats, Sprague-Dawley; Tail; Tryptamines; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins

1999
Differences in gonadotropin-releasing hormone-induced calcium signaling between melatonin-sensitive and melatonin-insensitive neonatal rat gonadotrophs.
    Endocrinology, 2000, Volume: 141, Issue:3

    Topics: Animals; Animals, Newborn; Antioxidants; Apamin; Calcium; Calcium Channel Blockers; Calcium Signaling; Electrophysiology; Enzyme Inhibitors; Female; Gonadotropin-Releasing Hormone; Melatonin; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pituitary Gland; Potassium Channels; Rats; Ryanodine; Staurosporine; Type C Phospholipases

2000
Melatonin and its analogs potentiate the nifedipine-sensitive high-voltage-activated calcium current in the chick embryonic heart cells.
    Journal of pineal research, 2001, Volume: 30, Issue:1

    Topics: Animals; Antioxidants; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Chick Embryo; Drug Synergism; Melatonin; Membrane Potentials; Myocardium; Nifedipine; Patch-Clamp Techniques; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin

2001
Melatonin modulates [3h]serotonin release in the rat hippocampus: effects of circadian rhythm.
    Journal of neuroendocrinology, 2002, Volume: 14, Issue:3

    Topics: Animals; Calcium Channel Blockers; Circadian Rhythm; Hippocampus; In Vitro Techniques; Male; Melatonin; Nifedipine; Photoperiod; Potassium Chloride; Rats; Rats, Sprague-Dawley; Serotonin; Tritium

2002
Effect of melatonin and nifedipine on some antioxidant enzymes and different energy fuels in the blood and brain of global ischemic rats.
    Journal of pineal research, 2002, Volume: 33, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Blood; Brain; Calcium Channel Blockers; Disease Models, Animal; Energy Metabolism; Enzymes; Erythrocytes; Free Radical Scavengers; Glucose; Glutathione Reductase; Ischemic Attack, Transient; L-Lactate Dehydrogenase; Male; Melatonin; Nifedipine; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Superoxide Dismutase

2002
Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland.
    Life sciences, 2008, Feb-27, Volume: 82, Issue:9-10

    Topics: 5-Hydroxytryptophan; Acetylserotonin O-Methyltransferase; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Arylalkylamine N-Acetyltransferase; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Chromatography, High Pressure Liquid; Cyclic CMP; Dose-Response Relationship, Drug; Electrochemistry; In Vitro Techniques; Isoproterenol; Melatonin; Nifedipine; Norepinephrine; Pineal Gland; Rats; Rats, Wistar; Serotonin; Tryptophan Hydroxylase

2008
Neuroprotection by melatonin on astrocytoma cell death.
    Annals of the New York Academy of Sciences, 2009, Volume: 1171

    Topics: Antioxidants; Apoptosis; Astrocytoma; Benzoquinones; Biological Transport; Calcium; Calcium Channel Blockers; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Lipoxygenase Inhibitors; Melatonin; Neomycin; Neuroprotective Agents; Nifedipine; Protein Synthesis Inhibitors; Receptors, Melatonin; Tryptamines; Type C Phospholipases

2009