nifedipine has been researched along with isradipine in 128 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (31.25) | 18.7374 |
| 1990's | 64 (50.00) | 18.2507 |
| 2000's | 12 (9.38) | 29.6817 |
| 2010's | 12 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Einzinger, U; Hoda, JC; Huber, IG; Koschak, A; Obermair, GJ; Sartori, SB; Sinnegger-Brauns, MJ; Striessnig, J; Wild, C | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Reimão, JQ; Scotti, MT; Tempone, AG | 1 |
| Sun, H | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Bharathi, K; Prasad, KV; Prasanthi, G | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Burger, KJ; Burger, W; Fuchs, S; Kober, G | 1 |
| Caricati-Neto, A; Castillo, CJ; García, AG; Jurkiewicz, A; Jurkiewicz, NH; Lafayette, S; Sette, M | 1 |
| Inagaki, O; Kato, Y; Kimura, R; Matsuoka, Y; Yamada, S | 1 |
| Gałewski, S; Kossut, M; Pomorski, P; Skangiel-Kramska, J | 1 |
| Kato, Y; Kimura, R; Matsuoka, Y; Sugimoto, N; Suzuki, N; Yamada, S | 1 |
| Ardilouze, JL; Bkaily, G; Bonneau, D; Corcos, J; Economos, D; Fong, CN; Marriott, C; Potvin, L | 1 |
| Goldmann, S; Stoltefuss, J; Triggle, DJ; Zheng, W | 1 |
| Burger, KJ; Distler, GA; Gross, P; Koppenhagen, K; Welzel, D; Wudel, E | 2 |
| Colombo, G; Fadda, F; Garau, B; Gessa, GL | 1 |
| Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Morozova, TE; Ol'binskaia, LI; Vartanova, OA | 1 |
| Mason, RP; Moisey, DM; Shajenko, L | 1 |
| Böhm, M; Erdmann, E; Schwinger, RH | 3 |
| Burger, KJ; Weidinger, G; Welzel, D | 1 |
| Hess, OM; Hoppeler, H; Hug, R; Krayenbühl, HP; Turina, J | 1 |
| Burger, K; Burger, W; Herholz, H; Kober, G | 1 |
| Gu, XH; Nayler, WG | 1 |
| Botelho, MA; Correia, JM; Mariano-Pego, G; Rocha-Gonçalves, F; Viegas, J | 1 |
| Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A | 1 |
| Currie, P; Saltissi, S | 1 |
| Ickrath, O; Karsch, KR; Kühlkamp, V; Mauser, M; Voelker, W | 1 |
| Burger, KJ; Kornecki, P; Mitrovic, V; Rieckmann, C; Schlepper, M; Welzel, D | 1 |
| Burger, KJ; Welzel, D | 1 |
| Hosey, MM; McMahon, KK; Ptasienski, J | 1 |
| Benavides, J; Bertrand, P; Burgevin, MC; Doble, A; Ferris, O; Gueremy, C; Le Fur, G; Menager, J; Uzan, A; Vaucher, N | 1 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Cognard, C; Fosset, M; Galizzi, JP; Lazdunski, M; Romey, G | 1 |
| Carpenter, CL; Greenberg, DA; Messing, RO | 1 |
| Cauvin, C; Hwang, O; van Breemen, C; Yamamoto, M | 1 |
| Holck, M; Osterrieder, W | 1 |
| Abram, A; Baginski, T; Banning, J; Rao, V | 1 |
| DeRoth, L; Godfraind, T; Wibo, M | 1 |
| Lamb, GD; Walsh, T | 1 |
| Chaumet-Riffaud, P; Lemaire, M; Pinquier, JL; Tillement, JP; Urien, S | 1 |
| Massieu, L; Tapia, R | 1 |
| Akbarali, H; Gilbert, R; Hall, J; Moody-Corbett, F | 1 |
| Burger, W; Kober, G; Neidel, S | 1 |
| Fitscha, P; O'Grady, J; Sinzinger, H; Weiss, K | 1 |
| Fitscha, P; Gazsó, A; Gludovacz, D; Sinzinger, H; Weiss, K | 1 |
| Matlib, MA | 1 |
| Chaumet-Riffaud, P; Pinquier, JL; Tillement, JP; Urien, S | 1 |
| Magill, SB; Parmar, SS; Stone, JS | 1 |
| Ickrath, O; Karsch, KR; Mauser, M; Voelker, W | 2 |
| Ferry, DR; Glossmann, H; Goll, A; Linn, T | 1 |
| Godfraind, T; Morel, N | 1 |
| Al-Mahmood, HA; el-Khatim, MS; Gumaa, KA; Thulesius, O | 1 |
| Handley, DA; Melden, MK; Saunders, RN; Van Valen, RG | 1 |
| Allen, J; Jackson, NC; Pool, PE; Taylor, SH | 1 |
| Hof, RP | 1 |
| Chaumet-Riffaud, P; Kiechel, JR; Paquette, B; Pinquier, JL; Tillement, JP; Urien, S | 1 |
| del Pozo, E; Sieber, C | 1 |
| Navarro, J; Tauber, AI; Williamson, KC | 1 |
| Handler, CE; Najm, Y; Rosenthal, E; Tsagadopoulos, D | 1 |
| Barrès, C; Cerutti, C; Morin, B; Sassard, J | 1 |
| Karsch, KR; Mauser, M; Voelker, W | 1 |
| Navarro, J | 1 |
| Jie, K; Timmermans, PB; van Brummelen, P; van Zwieten, PA; Vermey, P | 1 |
| Oswald, RE; Weiland, GA | 1 |
| Lee, HR; Roeske, WR; Yamamura, HI | 1 |
| Karobath, M; Supavilai, P | 1 |
| Müller-Schweinitzer, E; Neumann, P | 1 |
| Cortés, R; Karobath, M; Palacios, JM; Supavilai, P | 1 |
| Ferry, DR; Glossmann, H; Goll, A | 1 |
| Blanksma, PK; de Vries, RJ; Hillege, HJ; Lie, KI; Portegies, MC; van Gilst, WH; van Veldhuisen, DJ; Wout van den Toren, E | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Sullivan, JP | 1 |
| Dall'Olio, R; Gaggi, R; Gianni, AM; Roncada, P | 1 |
| Chavkin, C; Gibbs, SM; Simmons, ML; Terman, GW | 1 |
| Hattori, K; Maruyama, K; Nagatomo, T; Qu, YL; Sugiyama, K; Takamizawa, C; Watanabe, K | 1 |
| Anderson, K; Meissner, G | 1 |
| Ishiguro, S; Miyamoto, A; Nishio, A; Sakaguchi, H | 1 |
| Brée, F; Carrupt, PA; Giroud, Y; Testa, B; Tillement, JP; Tsai, RS; Urien, S | 1 |
| Nishio, A; Sakaguchi, H | 1 |
| Fitzpatrick, LA; Maercklein, PB; Ritchie, CK | 1 |
| Głazewski, S; Kossut, M; Skangiel-Kramska, J | 1 |
| Buxton, BF; Casley, D; Dauer, R; Gallicchio, M; Johnston, CI; Liu, JJ; Wojta, J | 1 |
| Kimura, R; Matsuoka, Y; Yamada, S | 1 |
| Aoudjit, F; Dupuis, G; Payet, MD; Ricard, I | 1 |
| Coves, MJ; Gomis, R; Novials, A; Vidal, J | 1 |
| Burger, KJ; Griebenow, R; Müller, R; Steffen, HM; Welzel, D | 1 |
| Ader, JL; Durand, D; Lloveras, JJ; Rostaing, L; Suc, JM; Tack, I; Tran-Van, T | 1 |
| Benchekroun, MT; Bkaily, G; D'Orleans-Juste, P; Gros-Louis, N | 1 |
| Abbott, K; Bakris, GL; Smith, A | 1 |
| Akopov, SE | 1 |
| Finkel, MS; Mayer, OH; Oddis, CV | 1 |
| Hirota, K; Lambert, DG | 1 |
| Brauns, T; Glossmann, H; Haugland, RP; Kimball, SD; Prinz, H; Striessnig, J | 1 |
| Bednarczyk, EM; Bissada, NF; Carlson, M; Sheehan, H; Westbrook, P | 1 |
| D'Allolio, R; Gaggi, R; Roncada, P; Santangelo, M | 1 |
| Inami, T; Kizawa, Y; Kotake, H; Kusama, T; Murakami, H; Nakajima, Y; Nakano, J | 1 |
| Bkaily, G; D'Orléans-Juste, P; Economos, D; Jaalouk, D; Jacques, D; Naik, R; Pothier, P | 1 |
| Kanaya, N; Kawana, S; Kimura, H; Matsumoto, M; Miyamoto, A; Namiki, A; Ohshika, H; Tsuchida, H | 1 |
| Ahmed, MS; Cemerikic, B; Zamah, R | 1 |
| Seibold, JR; Sturgill, MG | 1 |
| Chan, L; Jacob, LP; Malhotra, D; Shapiro, JI | 1 |
| Borges, AC; Paiva, TB; Prioste, RN; Shimuta, SI | 1 |
| Grant, KA; Green, KL | 1 |
| Kimura, R; Uchida, S; Urayama, A; Yamada, S | 1 |
| Gonon, A; Nordlander, M; Rydén, L; Segawa, D; Sjöquist, PO; Wang, QD | 1 |
| Aiello, EA; Chiappe de Cingolani, GE; Cingolani, HE; Mattiazzi, AR; Morgan, PE | 1 |
| Grant, KA; Green-Jordan, K | 1 |
| Bidet, M; Martial, S; Martin, D; Melendez, E; Namorado, MD; Poujeol, C; Poujeol, P; Reyes, JL; Sanchez, E; Tauc, M; Valencia, L | 1 |
| Dunn, SM; Oz, M; Tchugunova, YB | 1 |
| Kimura, R; Nakajima, M; Uchida, S; Yamada, S | 1 |
| Bkaily, G; Chahine, M; D'Orléans-Juste, P; Jacques, D; Jasmin, G | 1 |
| Prisant, LM; Spaulding, VC | 1 |
| Sahney, S | 1 |
| Beydemir, S; Söyüt, H; Türkeş, C | 1 |
| Daschil, N; Humpel, C | 1 |
| Albillos, A; Alonso Y Gregorio, S; Blázquez, J; Caba-González, JC; Carmona-Hidalgo, B; de Castro-Guerín, C; García-Magro, N; González-Enguita, C; Hernández-Vivanco, A; Jiménez-Pompa, A; Passas, J; Pérez-Alvarez, A; Sanz-Lázaro, S; Tabernero, A | 1 |
| Ding, WG; Dubel, S; Mangoni, ME; Matsuura, H; Mesirca, P; Striessnig, J; Toyoda, F | 1 |
3 review(s) available for nifedipine and isradipine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
New drugs for hypertension--variations on old themes.
Topics: Amlodipine; Antihypertensive Agents; Delayed-Action Preparations; Dihydropyridines; Doxazosin; Humans; Hypertension; Isradipine; Nifedipine; Prazosin; Verapamil | 1991 |
A review of calcium channel antagonists in the treatment of pediatric hypertension.
Topics: Amiodarone; Calcium Channel Blockers; Child; Felodipine; Humans; Hypertension; Isradipine; Nicardipine; Nifedipine; Verapamil | 2006 |
23 trial(s) available for nifedipine and isradipine
| Article | Year |
|---|---|
Comparison of negative inotropic and vasodilator effects of isradipine and nifedipine after complete autonomic blockade in ischemic heart disease.
Topics: Autonomic Nerve Block; Depression, Chemical; Double-Blind Method; Heart Rate; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Nifedipine; Vascular Resistance; Vasodilator Agents | 1992 |
Hemodynamic effects of isradipine and nifedipine in chronic sustained hypertension.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Isradipine; Middle Aged; Nifedipine | 1992 |
Calcium antagonists as first-line antihypertensive agents: a placebo-controlled, comparative trial of isradipine and nifedipine.
Topics: Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged; Nifedipine; Patient Compliance; Pyridines; Randomized Controlled Trials as Topic | 1990 |
Effect of isradipine on left ventricular relaxation and diastolic filling.
Topics: Angiocardiography; Blood Pressure; Calcium Channel Blockers; Cardiac Catheterization; Coronary Disease; Heart; Heart Ventricles; Hemodynamics; Humans; Isradipine; Middle Aged; Myocardial Contraction; Nifedipine; Pyridines | 1990 |
Antiischemic and hemodynamic effects of intravenous isradipine, a new calcium antagonist, in coronary heart disease: a comparative double-blind cross-over study with nifedipine.
Topics: Calcium Channel Blockers; Coronary Disease; Double-Blind Method; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Nifedipine; Physical Exertion; Pyridines | 1990 |
First clinical experience with isradipine in the treatment of hypertension in Portugal.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged; Nifedipine; Portugal | 1991 |
Isradipine therapy in chronic stable angina pectoris--comparison with nifedipine.
Topics: Activities of Daily Living; Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Exercise Test; Hemodynamics; Humans; Isradipine; Middle Aged; Nifedipine; Pyridines | 1991 |
[The hemodynamic effects of isradipine and nifedipine in hypertension].
Topics: Adult; Blood Pressure; Cardiac Output; Dihydropyridines; Female; Heart; Heart Function Tests; Humans; Hypertension; Injections, Intravenous; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine; Propranolol; Stroke Volume | 1991 |
[Myocardial effects of the calcium antagonists nifedipine, nisoldipine and isradipine in coronary heart disease].
Topics: Blood Pressure; Calcium Channel Blockers; Coronary Disease; Heart; Heart Rate; Humans; Infusions, Intravenous; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine; Nisoldipine; Pyridines; Vascular Resistance | 1990 |
Effects of the calcium antagonist, isradipine, and nifedipine on resting and exercise haemodynamics and the neurohumoral system in patients with stable chronic angina.
Topics: Angina Pectoris; Calcium Channel Blockers; Double-Blind Method; Epinephrine; Exercise Test; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Nifedipine; Norepinephrine; Pyridines; Radionuclide Ventriculography; Randomized Controlled Trials as Topic; Renin | 1990 |
The calcium antagonist isradipine in the therapy of hypertension. A double-blind crossover comparison with nifedipine.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Female; Humans; Hypertension; Isradipine; Male; Middle Aged; Nifedipine; Pyridines | 1990 |
Hemodynamic and antianginal effects during rest and exercise of intravenous isradipine, a new dihydropyridine calcium antagonist.
Topics: Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Electrocardiography; Exercise Test; Hemodynamics; Humans; Injections, Intravenous; Isradipine; Male; Middle Aged; Nifedipine; Pyridines; Random Allocation | 1989 |
Efficacy of a new calcium antagonist PN 200-110 (isradipine) in angina pectoris.
Topics: Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Humans; Isosorbide Dinitrate; Isradipine; Male; Nifedipine; Oxadiazoles; Placebos | 1987 |
Comparison of isradipine and nifedipine in chronic stable angina.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Electrocardiography; Exercise Test; Humans; Isradipine; Male; Middle Aged; Nifedipine; Pyridines; Random Allocation | 1988 |
[Isradipine (PN 200-110), a new dihydropyridine calcium antagonist with slight negative inotropic properties in comparison with nifedipine].
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Isradipine; Middle Aged; Myocardial Contraction; Nifedipine; Pyridines; Vascular Resistance | 1988 |
Influence of calcium entry blockade on alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in the forearm of hypertensive patients.
Topics: Adult; Azepines; Calcium Channel Blockers; Female; Forearm; Hemodynamics; Humans; Hypertension; Isradipine; Male; Methoxamine; Middle Aged; Nifedipine; Oxadiazoles; Receptors, Adrenergic, alpha; Regional Blood Flow; Vascular Resistance; Vasoconstriction | 1987 |
Effect of isradipine and nifedipine on diastolic function in patients with left ventricular dysfunction due to coronary artery disease: a randomized, double-blind, nuclear, stethoscope study.
Topics: Adult; Aged; Angina Pectoris; Atrial Function, Right; Cardiac Pacing, Artificial; Diastole; Double-Blind Method; Female; Heart Auscultation; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Myocardial Ischemia; Nifedipine; Systole; Ventricular Function, Left | 1994 |
Effects of isradipine and nifedipine retard in hypertensive patients with type II diabetes mellitus.
Topics: Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Isradipine; Lipids; Male; Middle Aged; Nifedipine; Treatment Outcome | 1993 |
Effect of short-term antihypertensive therapy on left ventricular wall tension. A double-blind comparison of isradipine and nifedipine.
Topics: Cardiac Volume; Double-Blind Method; Female; Heart Ventricles; Humans; Hypertension; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine | 1993 |
[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease].
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Disease; Electrocardiography; Exercise Test; Felodipine; Female; Hemodynamics; Humans; Infusions, Intravenous; Isradipine; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Nifedipine; Nisoldipine | 1993 |
Renal functional reserve in calcium channel blocker-treated hypertensive recipients of kidney transplant.
Topics: Adult; Amino Acids; Calcium Channel Blockers; Cyclosporine; Female; Glomerular Filtration Rate; Humans; Hypertension, Renal; Isradipine; Kidney Transplantation; Male; Middle Aged; Nifedipine; Nitrendipine; Renal Plasma Flow; Retrospective Studies | 1995 |
Effects of dihydropyridine calcium antagonists on albuminuria in patients with diabetes.
Topics: Adult; Albuminuria; Calcium Channel Blockers; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet, Sodium-Restricted; Female; Humans; Hypertension; Isradipine; Male; Nifedipine; Prospective Studies | 1996 |
Regression of nifedipine-induced gingival hyperplasia following switch to a same class calcium channel blocker, isradipine.
Topics: Adult; Aged; Antihypertensive Agents; Biopsy; Calcium Channel Blockers; Dental Plaque Index; Evaluation Studies as Topic; Female; Follow-Up Studies; Gingiva; Gingival Hyperplasia; Gingival Pocket; Gingival Recession; Humans; Hypertension; Incidence; Isradipine; Male; Middle Aged; Models, Dental; Nifedipine; Oral Hygiene; Periodontal Index; Photography; Remission Induction; Single-Blind Method | 1997 |
102 other study(ies) available for nifedipine and isradipine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Topics: Amino Acid Motifs; Animals; Brain; Calcium Channels, L-Type; Dihydropyridines; Female; Gene Expression; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Isoforms | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study.
Topics: Animals; Antiprotozoal Agents; Cell Line; Cricetinae; Dihydropyridines; Erythrocytes; Leishmania; Macaca mulatta; Mice; Parasitic Sensitivity Tests; Quantitative Structure-Activity Relationship; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.
Topics: Carboxylic Acids; Cytochrome P-450 Enzyme System; Esters; Humans; Hydrolysis; Microsomes; Models, Molecular; Molecular Structure; Prodrugs; Quantum Theory; Signal Transduction | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Design, synthesis and evaluation of dialkyl 4-(benzo[d][1,3]dioxol-6-yl)-1,4-dihydro-2,6-dimethyl-1-substituted pyridine-3,5-dicarboxylates as potential anticonvulsants and their molecular properties prediction.
Topics: Absorption; Analgesics; Animals; Anticonvulsants; Antioxidants; Chemistry Techniques, Synthetic; Drug Design; Male; Mice; Pyridines; Rats | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Low dihydropyridine receptor density in vasa deferentia of castrated rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Male; Membranes; Nifedipine; Orchiectomy; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Vas Deferens | 1992 |
A sustained occupancy in vivo of cardiovascular calcium antagonist receptors by mepirodipine and its relation to pharmacodynamic effect in spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Blood Pressure; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Hypertension; Isradipine; Male; Myocardium; Nifedipine; Rats; Rats, Inbred SHR; Receptors, Nicotinic | 1992 |
Voltage-dependent L-type calcium channels in the development and plasticity of mouse barrel cortex.
Topics: Aging; Animals; Autoradiography; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Mice; Neuronal Plasticity; Nifedipine; Somatosensory Cortex; Tritium; Vibrissae | 1992 |
Determination of a novel calcium channel antagonist, mepirodipine, in plasma by radioreceptor assay using (+)-[3H]PN 200-110.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; In Vitro Techniques; Isradipine; Male; Nifedipine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Regression Analysis; Reproducibility of Results | 1992 |
Blockade of insulin sensitive steady-state R-type Ca2+ channel by PN 200-110 in heart and vascular smooth muscle.
Topics: Animals; Calcium; Calcium Channels; Chick Embryo; Cytophotometry; Fura-2; Heart; Humans; Insulin; Isradipine; Membrane Potentials; Microelectrodes; Muscle, Smooth, Vascular; Nifedipine; Potassium; Potassium Channels; Rabbits | 1992 |
Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arteries; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; Drug Antagonism; Heart; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Nifedipine; Radioligand Assay; Rats | 1992 |
Isradipine and other calcium channel antagonists attenuate ethanol consumption in ethanol-preferring rats.
Topics: Alcohol Drinking; Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Ethanol; Isradipine; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Evidence for the presence of regional differences in the calcium antagonist receptors in lower urinary tract smooth muscle.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Carbachol; Dihydropyridines; Drug Interactions; Female; Isradipine; Muscle Contraction; Muscle, Smooth; Nifedipine; Rabbits; Urinary Tract | 1992 |
[The calcium antagonist isradipine (Lomir) in the treatment of patients with essential hypertension].
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Drug Tolerance; Female; Guanfacine; Hemodynamics; Humans; Hypertension; Isradipine; Male; Middle Aged; Nifedipine | 1992 |
Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Cholesterol; Dihydropyridines; Diltiazem; Electrons; Isradipine; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nitrendipine; Phosphatidylcholines; Rabbits; Verapamil | 1992 |
Negative inotropic properties of isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardial tissue.
Topics: Adult; Aged; Calcium Channel Blockers; Calcium Chloride; Diltiazem; Electric Stimulation; Female; Heart; Heart Diseases; Humans; In Vitro Techniques; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine; Papillary Muscles; Pyridines; Verapamil | 1990 |
(-)[3H]amlodipine binding to rat cardiac membranes.
Topics: Amlodipine; Animals; Female; Gallopamil; Hydrogen-Ion Concentration; In Vitro Techniques; Isradipine; Kinetics; Membranes; Myocardium; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains; Stereoisomerism; Temperature | 1991 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium Channel Blockers; Cerebellum; Dihydropyridines; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Isradipine; Kainic Acid; Nerve Degeneration; Nervous System Diseases; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Negative inotropic activity of the calcium antagonists isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardium.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Dose-Response Relationship, Drug; Heart Diseases; Humans; Hypertension; Isradipine; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Pyridines; Vasodilation; Verapamil | 1991 |
Different negative inotropic activity of Ca2(+)-antagonists in human myocardial tissue.
Topics: Calcium Channel Blockers; Depression, Chemical; Diltiazem; Heart Atria; Heart Failure; Heart Transplantation; Humans; Isradipine; Myocardial Contraction; Nifedipine; Nitrendipine; Papillary Muscles; Pyridines; Verapamil | 1990 |
High and low affinity states of the dihydropyridine and phenylalkylamine receptors on the cardiac calcium channel and their interconversion by divalent cations.
Topics: Animals; Calcium; Cations, Divalent; Chickens; Dihydropyridines; Heart; Ion Channels; Isradipine; Magnesium; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1985 |
Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determination.
Topics: Animals; Benzodiazepinones; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Fractionation; Dogs; Ion Channels; Isoquinolines; Isradipine; Male; Molecular Weight; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Nicotinic; Sarcolemma; Sarcoplasmic Reticulum; Verapamil | 1985 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
Dihydropyridine-sensitive Ca2+ channels in mammalian skeletal muscle cells in culture: electrophysiological properties and interactions with Ca2+ channel activator (Bay K8644) and inhibitor (PN 200-110).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Cells, Cultured; Electric Conductivity; Ion Channels; Isradipine; Membrane Potentials; Muscles; Nifedipine; Oxadiazoles; Rats | 1986 |
Depolarization-dependent binding of the calcium channel antagonist, (+)-[3H]PN200-110, to intact cultured PC12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium; Calcium Channel Blockers; Cells, Cultured; Isradipine; Kinetics; Membrane Potentials; Nifedipine; Nitrendipine; Onium Compounds; Organophosphorus Compounds; Oxadiazoles; Potassium; Pyridines; Tritium | 1986 |
Effects of dihydropyridines on tension and calcium-45 influx in isolated mesenteric resistance vessels from spontaneously hypertensive and normotensive rats.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Female; Ion Channels; Isradipine; Mesenteric Arteries; Nifedipine; Nisoldipine; Norepinephrine; Oxadiazoles; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance | 1987 |
Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential-dependent blockade by Ro 18-3981.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Female; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Isradipine; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Oxadiazoles; Potassium; Pyridines | 1987 |
Effect of daunorubicin on dihydropyridine-sensitive binding sites in cardiac sarcolemma.
Topics: Animals; Calcium; Cricetinae; Daunorubicin; Dihydropyridines; Female; In Vitro Techniques; Ion Channels; Isradipine; Male; Myocardial Contraction; Myocardium; Nifedipine; Oxadiazoles; Sarcolemma | 1987 |
Pharmacologic relevance of dihydropyridine binding sites in membranes from rat aorta: kinetic and equilibrium studies.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Binding, Competitive; Calcium; Calcium Channels; Ion Channels; Isradipine; Kinetics; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Stereoisomerism | 1988 |
Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Rabbits; Rats; Time Factors | 1987 |
Comparative binding of two closely related dihydropyridines (isradipine and darodipine) to serum proteins and erythrocytes.
Topics: Binding, Competitive; Blood Proteins; Calcium Channel Blockers; Dihydropyridines; Erythrocytes; gamma-Globulins; Humans; Isradipine; Lipoproteins; Nifedipine; Pyridines | 1988 |
Relationship of dihydropyridine binding sites with calcium-dependent neurotransmitter release in synaptosomes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Aminopyridines; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; gamma-Aminobutyric Acid; Ion Channels; Isradipine; Lanthanum; Male; Mice; Neurotransmitter Agents; Nifedipine; Nitrendipine; Oxadiazoles; Potassium; Receptors, Nicotinic; Ruthenium Red; Synaptosomes | 1988 |
Calcium current in embryonic Xenopus muscle cells in culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Cells, Cultured; Embryo, Nonmammalian; Isradipine; Muscles; Nifedipine; Oxadiazoles; Xenopus | 1989 |
Isradipine: a potent calcium blocker with beneficial effects on platelet function and vascular prostacyclin production.
Topics: Adenosine Diphosphate; Adult; Animals; Calcium Channel Blockers; Collagen; Epoprostenol; Humans; Isradipine; Male; Nifedipine; Platelet Aggregation Inhibitors; Pyridines; Rats; Rats, Inbred Strains | 1989 |
Calcium blockers: antiatherogenic action by influencing the prostaglandin-system.
Topics: Adult; Animals; Arteriosclerosis; Calcium Channel Blockers; Diltiazem; Epoprostenol; Female; Humans; In Vitro Techniques; Isradipine; Male; Malondialdehyde; Nifedipine; Platelet Aggregation; Prostaglandins; Pyridines; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Relaxation of potassium chloride-induced contractions by amlodipine and its interaction with the 1,4-dihydropyridine-binding site in pig coronary artery.
Topics: Amlodipine; Animals; Binding Sites; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Isradipine; Nifedipine; Oxadiazoles; Potassium Chloride; Sarcolemma; Stereoisomerism; Swine; Vasoconstriction; Vasodilation | 1989 |
Differences in the serum binding determinants of isradipine and darodipine--consequences for serum protein binding in various diseases.
Topics: Adult; Blood Proteins; Calcium Channel Blockers; Fatty Acids, Nonesterified; Female; Humans; Hydrogen-Ion Concentration; Inflammation; Isradipine; Liver Diseases; Male; Middle Aged; Nifedipine; Orosomucoid; Protein Binding; Pyridines; Serum Albumin | 1989 |
High affinity binding of the calcium channel blocker, (+)-[methyl-3H]PN200-110(3HPN) in rat brain.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Isradipine; Male; Nifedipine; Oxadiazoles; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Synaptosomes | 1989 |
Myocardial properties of the new dihydropyridine calcium antagonist isradipine compared to nifedipine with or without additional beta blockade in coronary artery disease.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Disease; Drug Therapy, Combination; Heart Rate; Humans; Isradipine; Middle Aged; Myocardial Contraction; Nifedipine; Propranolol; Pyridines | 1989 |
Molecular approach to the calcium channel.
Topics: Animals; Benzothiazoles; Binding Sites; Brain; Calcium; Cattle; Chemical Phenomena; Chemistry; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles; Thiazoles; Verapamil | 1985 |
Selective modulation by membrane potential of the interaction of some calcium entry blockers with calcium channels in rat mesenteric artery.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Flunarizine; In Vitro Techniques; Isradipine; Membrane Potentials; Membranes; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1988 |
The effect of calcium-blockers nicardipine, darodipine, PN-200-110 and nifedipine on insulin release from isolated rat pancreatic islets.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isradipine; Male; Nicardipine; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1986 |
Suppression of rat carotid lesion development by the calcium channel blocker PN 200-110.
Topics: Angioplasty, Balloon; Animals; Arteriosclerosis; Blood Platelets; Blood Pressure; Carotid Arteries; Hypotension; Isradipine; Male; Muscle, Smooth, Vascular; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1986 |
Comparison of cardiodepressant and vasodilator effects of PN 200-110 (isradipine), nifedipine and diltiazem in anesthetized rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dose-Response Relationship, Drug; Heart; Isradipine; Myocardial Contraction; Nifedipine; Oxadiazoles; Rabbits; Vasodilation | 1987 |
Effect of the binding of isradipine and darodipine to different plasma proteins on their transfer through the rat blood-brain barrier. Drug binding to lipoproteins does not limit the transfer of drug.
Topics: Animals; Biological Transport; Blood Proteins; Blood-Brain Barrier; Brain; Humans; Isradipine; Lipoproteins; Liver; Male; Nifedipine; Orosomucoid; Pyridines; Rats; Rats, Inbred Strains; Serum Albumin | 1987 |
Failure of a new calcium-antagonist PN 200-110 and nifedipine to affect exercise stimulated GH-secretion in healthy volunteers.
Topics: Adult; Calcium Channel Blockers; Growth Hormone; Humans; Isradipine; Male; Nifedipine; Oxadiazoles; Physical Exertion | 1987 |
Nisoldepine inhibits formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe) receptor-coupled calcium transport in human neutrophils.
Topics: Adult; Biological Transport; Calcium; Calcium Channel Blockers; Humans; In Vitro Techniques; Isradipine; Neutrophils; Nifedipine; Nisoldipine; Oxadiazoles; Receptors, Formyl Peptide; Receptors, Immunologic | 1987 |
Cardiovascular effects of two new calcium antagonists, PY 108-068 and PN 200-110, in conscious spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Isradipine; Male; Nifedipine; Nitroglycerin; Oxadiazoles; Phenylephrine; Pressoreceptors; Rats; Rats, Inbred SHR; Reflex | 1988 |
Dihydropyridine [methyl-3H]PN 200-110 binding and myogenesis in intact muscle cells in vitro.
Topics: Aminoquinolines; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Isradipine; Kinetics; Muscles; Nifedipine; Nitrendipine; Oxadiazoles; Receptors, Nicotinic | 1986 |
The mechanism of binding of dihydropyridine calcium channel blockers to rat brain membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Isomerism; Isradipine; Kinetics; Mathematics; Nifedipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Time Factors | 1985 |
High affinity specific [3H](+)PN 200-110 binding to dihydropyridine receptors associated with calcium channels in rat cerebral cortex and heart.
Topics: Animals; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Ion Channels; Isradipine; Kinetics; Male; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1984 |
The interaction of [3H]PY 108-068 and of [3H]PN 200-110 with calcium channel binding sites in rat brain.
Topics: Animals; Brain; In Vitro Techniques; Ion Channels; Isradipine; Kinetics; Male; Membranes; Molecular Conformation; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1984 |
In vitro effects of calcium antagonists PN 200-110, nifedipine, and nimodipine on human and canine cerebral arteries.
Topics: Animals; Basilar Artery; Blood Physiological Phenomena; Calcium Channel Blockers; Cerebral Arteries; Dogs; Humans; In Vitro Techniques; Isradipine; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nicotinic Acids; Nifedipine; Nimodipine; Oxadiazoles; Serotonin; Vasoconstriction | 1983 |
Calcium antagonist binding sites in the rat brain: quantitative autoradiographic mapping using the 1,4-dihydropyridines [3H]PN 200-110 and [3H]PY 108-068.
Topics: Animals; Autoradiography; Binding Sites; Brain; Calcium Channel Blockers; Isradipine; Male; Nifedipine; Oxadiazoles; Rats; Rats, Inbred Strains | 1984 |
Differential labelling of putative skeletal muscle calcium channels by [3H]-nifedipine, [3H]-nitrendipine, [3H]-nimodipine and [3H]-PN 200 110.
Topics: Animals; Calcium Channel Blockers; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Kinetics; Muscles; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles | 1983 |
Functional modulation of human "ganglionic-like" neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cadmium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Isradipine; Neuroblastoma; Neurons; Nicotine; Nifedipine; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Receptors, Nicotinic; Spider Venoms; Tumor Cells, Cultured; Verapamil | 1995 |
Peculiar effects of isradipine and darodipine on the rat brain dopaminergic system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Calcium Channel Blockers; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Injections, Intraperitoneal; Isradipine; Male; Motor Activity; Nifedipine; Nimodipine; Parietal Lobe; Rats; Rats, Sprague-Dawley | 1995 |
L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells.
Topics: Animals; Axons; Calcium Channel Blockers; Calcium Channels; Dendrites; Dynorphins; Guinea Pigs; Hippocampus; Isradipine; Long-Term Potentiation; Naltrexone; Nifedipine; omega-Conotoxin GVIA; Peptides; Receptors, Opioid, kappa | 1995 |
Residual inhibition in density of [3H]isradipine binding sites in rat brain membrane pretreated with amlodipine.
Topics: Amlodipine; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Nifedipine; Oxadiazoles; Radioligand Assay; Rats; Rats, Wistar | 1995 |
T-tubule depolarization-induced SR Ca2+ release is controlled by dihydropyridine receptor- and Ca(2+)-dependent mechanisms in cell homogenates from rabbit skeletal muscle.
Topics: Animals; Calcium; Calcium Channels, L-Type; Egtazic Acid; Electrophysiology; Isradipine; Microtubules; Muscle Proteins; Muscle, Skeletal; Nifedipine; Rabbits; Sarcoplasmic Reticulum; Verapamil | 1995 |
Enhanced contractile response to phenylephrine and increased density of [3H]PN200-110 binding sites in thoracic aorta isolated from dietary magnesium-deficient rats.
Topics: Animals; Aorta, Thoracic; Calcium Channels; Diet; Endothelium, Vascular; Isradipine; Magnesium Deficiency; Male; Muscle Contraction; Nifedipine; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 1994 |
Mechanism of ligand binding to alpha 1-acid glycoprotein (orosomucoid): correlated thermodynamic factors and molecular parameters of polarity.
Topics: Binding Sites; Chemical Phenomena; Chemistry, Physical; Hydrogen Bonding; Indoles; Isradipine; Ligands; Nifedipine; Orosomucoid; Progesterone; Propanolamines; Propranolol; Temperature; Thermodynamics; Warfarin | 1995 |
Mechanisms of the enhanced contractile response to phenylephrine in thoracic aorta isolated from rats with dietary magnesium deficiency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Diet; In Vitro Techniques; Isoquinolines; Isradipine; Magnesium Deficiency; Male; Nifedipine; Phenylephrine; Piperazines; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction | 1994 |
Direct effect of calcium channel antagonists on osteoclast function: alterations in bone resorption and intracellular calcium concentrations.
Topics: Animals; Bone Resorption; Calcium; Calcium Channel Blockers; Cells, Cultured; Intracellular Membranes; Isomerism; Isradipine; Nicotinic Acids; Nifedipine; Osmolar Concentration; Osteoclasts; Oxadiazoles; Rats; Whales | 1994 |
Development of NMDA receptor-channel complex and L-type calcium channels in mouse hippocampus.
Topics: Age Factors; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Isradipine; Mice; Nifedipine; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Effects of calcium- and ETA-receptor antagonists on endothelin-induced vasoconstriction and levels of endothelin in the human internal mammary artery.
Topics: Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Humans; In Vitro Techniques; Isradipine; Mammary Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrendipine; Peptides, Cyclic; Radioimmunoassay; Vasoconstriction | 1994 |
Correlation between the plasma concentration of mepirodipine and its occupancy of Ca2+ antagonist receptors in rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Isradipine; Male; Myocardium; Nifedipine; Radioligand Assay; Rats; Rats, Wistar | 1993 |
Effects of modulators of cytosolic Ca2+ on phytohemagglutin-dependent Ca2+ response and interleukin-2 production in Jurkat cells.
Topics: Affinity Labels; Azides; Binding Sites; Calcium; Calcium Channel Blockers; Cytosol; Dihydropyridines; Gallic Acid; Glycoproteins; Humans; Interleukin-2; Isradipine; Kinetics; Nifedipine; Phytohemagglutinins; Ryanodine; T-Lymphocytes; Tumor Cells, Cultured | 1993 |
R-type calcium channel involved in endothelin-1-induced contraction of rabbit aorta.
Topics: Animals; Aorta, Thoracic; Calcium Channels; Endothelins; Female; In Vitro Techniques; Isradipine; Male; Nifedipine; Rabbits; Receptors, Endothelin; Vasoconstriction | 1995 |
Nitric oxide (EDRF) enhances the vasorelaxing effect of dihydropyridine calcium antagonists in isolated human middle cerebral arteries.
Topics: Adult; Arginine; Calcium Channel Blockers; Cerebral Arteries; Cyclooxygenase Inhibitors; Dihydropyridines; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; In Vitro Techniques; Indomethacin; Isradipine; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Vasodilator Agents | 1996 |
Inotropic, chronotropic, and radioligand binding characteristics of leukotriene B4 in cardiac myocyte, papillary muscle, and membrane preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channels; Cardiotonic Agents; Cells, Cultured; Cricetinae; Heart Rate; Isradipine; Leukotriene B4; Myocardium; Nifedipine; Protein Binding; Ryanodine | 1996 |
A comparative study of L-type voltage sensitive Ca2+ channels in rat brain regions and cultured neuronal cells.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Female; Intracellular Membranes; Isradipine; Neurons; Nifedipine; Osmolar Concentration; PC12 Cells; Potassium; Rats; Rats, Wistar; Tumor Cells, Cultured | 1997 |
L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluorescent Dyes; Isomerism; Isradipine; Kinetics; Nicotinic Acids; Nifedipine; Nitrendipine; Oxadiazoles; Rabbits | 1997 |
Interactions between darodipine or isradipine and the 5-HT1A receptor agonist 8-OHDPAT in rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Interactions; Isradipine; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists | 1997 |
Synergistic actions of pentobarbital and dihydropyridine Ca2+ antagonists on guinea pig isolated thoracic aorta.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Drug Interactions; Guinea Pigs; Isradipine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Pentobarbital | 1997 |
Endothelin-1 and insulin activate the steady-state voltage dependent R-type Ca2+ channel in aortic smooth muscle cells via a pertussis toxin and cholera toxin sensitive G-protein.
Topics: Animals; Aorta; Caffeine; Calcium Channels; Cholera Toxin; Endothelin-1; GTP-Binding Proteins; Indoles; Insulin; Ion Transport; Isradipine; Maleimides; Muscle, Smooth, Vascular; Nifedipine; Pertussis Toxin; Protein Kinase C; Rabbits; Ryanodine; Virulence Factors, Bordetella | 1998 |
Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthetics, Inhalation; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Halothane; Heart Ventricles; Isradipine; Myocardial Contraction; Myocardium; Nifedipine; Rats; Rats, Wistar; Sarcolemma; Verapamil | 1998 |
Identification of L-type calcium channels associated with kappa opioid receptors in human placenta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Benzeneacetamides; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Membrane; Chorionic Gonadotropin; Chorionic Villi; Culture Techniques; Egtazic Acid; Female; Humans; Isradipine; Naltrexone; Nifedipine; Placenta; Pyrrolidines; Receptors, Opioid, kappa; Trophoblasts | 1998 |
Rational use of calcium-channel antagonists in Raynaud's phenomenon.
Topics: Amlodipine; Calcium Channel Blockers; Diltiazem; Felodipine; Humans; Isradipine; Nicardipine; Nifedipine; Raynaud Disease | 1998 |
Absence of a dose-response of cyclosporine levels to clinically used doses of diltiazem and verapamil.
Topics: Administration, Oral; Calcium Channel Blockers; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Isradipine; Medical Records; Nifedipine; Radioimmunoassay; Retrospective Studies; Verapamil | 1999 |
Different pathways for Ca2+ mobilization by angiotensin II and carbachol in the circular muscle of the guinea-pig ileum.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Calcium Channel Blockers; Carbachol; Electric Stimulation; Female; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Isradipine; Losartan; Male; Membrane Potentials; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Nickel; Nifedipine; Potassium Chloride; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrodotoxin; Vasoconstrictor Agents; Verapamil | 1999 |
Effects of L-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats.
Topics: Animals; Calcium Channel Blockers; Conditioning, Operant; Dihydropyridines; Discrimination Learning; Ethanol; Feeding Behavior; Isradipine; Male; Nifedipine; Rats; Taste | 1999 |
In vivo receptor occupancy and plasma concentration of pranidipine, a potent and long-acting dihydropyridine calcium antagonist.
Topics: Algorithms; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Isradipine; Male; Myocardium; Nifedipine; Rats; Rats, Inbred SHR | 1999 |
Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Coronary Circulation; Dihydropyridines; Heart Atria; Heart Block; Heart Rate; Isradipine; Male; Myocardial Contraction; Nifedipine; Pyridines; Rats; Rats, Sprague-Dawley; Systole; Ventricular Function, Left; Ventricular Pressure | 1999 |
Chronic administration of nifedipine induces up-regulation of functional calcium channels in rat myocardium.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cell Membrane; Cells, Cultured; Diastole; Heart; Heart Ventricles; In Vitro Techniques; Isradipine; Kinetics; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Patch-Clamp Techniques; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Systole; Tritium; Up-Regulation | 1999 |
Modulation of the ethanol-like discriminative stimulus effects of diazepam and phencyclidine by L-type voltage-gated calcium-channel ligands in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Central Nervous System Depressants; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Modulators; Isradipine; Ligands; Male; N-Methylaspartate; Nifedipine; Nimodipine; Phencyclidine; Rats; Rats, Long-Evans | 2000 |
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Cytosol; Dihydropyridines; Diltiazem; Egtazic Acid; Gadolinium; Hydrogen Peroxide; Isradipine; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Lanthanum; Nifedipine; Protamines; Rats; Rats, Sprague-Dawley; Thapsigargin; Verapamil | 2001 |
Direct inhibition of voltage-dependent Ca(2+) fluxes by ethanol and higher alcohols in rabbit T-tubule membranes.
Topics: Alcohols; Animals; Binding, Competitive; Butanols; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulation; Ethanol; Hexanols; Isradipine; Lanthanum; Nifedipine; Octanols; Rabbits; Structure-Activity Relationship | 2001 |
In vivo measurement of 1,4-dihydropyridine receptors in mesenteric arteries of spontaneously hypertensive rats and effect of nifedipine and cilnidipine.
Topics: Animals; Area Under Curve; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Dose-Response Relationship, Drug; Injections, Intravenous; Isradipine; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Inbred SHR; Tissue Distribution | 2002 |
Isradipine prevents the development of spontaneously occurring cardiac necrosis in cardiomyopathic hamster.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cardiomyopathy, Dilated; Cricetinae; Isradipine; Necrosis; Nifedipine; Sodium Channel Blockers | 2003 |
Antihypertensive pharmacobezoar.
Topics: Antihypertensive Agents; Bezoars; Calcium Channel Blockers; Drug Delivery Systems; Gastrointestinal Diseases; Humans; Isradipine; Nifedipine; Postoperative Complications; Tablets; Verapamil | 2006 |
Effect of calcium channel blockers on paraoxonase-1 (PON1) activity and oxidative stress.
Topics: Amlodipine; Aryldialkylphosphatase; Calcium Channel Blockers; Humans; Isradipine; Nifedipine; Nitrendipine; Oxidative Stress | 2014 |
Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses.
Topics: Animals; Axotomy; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Death; Cholinergic Neurons; Dopaminergic Neurons; Isradipine; Neuroimmunomodulation; Neuroprotective Agents; Nicardipine; Nifedipine; Nimodipine; Rats, Sprague-Dawley; Substantia Nigra; Tissue Culture Techniques; Ventral Tegmental Area; Verapamil | 2014 |
Human native Ca
Topics: Action Potentials; Calcium; Caveolin 1; Chromaffin Cells; Exocytosis; Humans; Isradipine; Nifedipine | 2017 |
Ca
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Heart Rate; Isradipine; Mice, Inbred C57BL; Mice, Knockout; Nifedipine; Patch-Clamp Techniques; Sinoatrial Node | 2017 |