nifedipine has been researched along with felodipine in 236 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 108 (45.76) | 18.7374 |
| 1990's | 71 (30.08) | 18.2507 |
| 2000's | 33 (13.98) | 29.6817 |
| 2010's | 22 (9.32) | 24.3611 |
| 2020's | 2 (0.85) | 2.80 |
| Authors | Studies |
|---|---|
| Alker, D; Campbell, SF; Cross, PE | 1 |
| Alker, D; Burges, RA; Campbell, SF; Carter, AJ; Cross, PE; Gardiner, DG | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Arrowsmith, JE; Blackburn, KJ; Burges, RA; Campbell, SF; Cross, PE; Gardiner, DG; Stubbs, JK | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Beaumont, K; Smith, DA; van De Waterbeemd, H; Walker, DK | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Abrego, VH; Amaro-Recillas, HA; Angeles, E; Marroquín-Pascual, JL; Martínez, L; Martínez-Pérez, B; Moya-Hernández, R; Rodríguez-Barrientos, D; Rojas-Hernández, A; Rueda-Jackson, JC; Torres, LA | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Sun, H | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Bakmiwewa, SM; Ball, HJ; Fatokun, AA; Hunt, NH; Payne, RJ; Tran, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Baig, MW; Davies, JA; Lees, AD; Orchard, MA; Perrins, EJ; Prentice, CR; Wilson, J | 1 |
| Johnson, JD; Oba, T; Wang, S; Yamaguchi, M | 1 |
| Lu, A; Oba, T; Sako, T; Yamaguchi, M; Yamano, S | 1 |
| Guido, S; Joseph, T | 1 |
| Edgar, B; Eriksson, UG; Lundahl, J; Miniscalco, A; Regårdh, CG | 1 |
| Messing, M; Smith, TL; Smits, JF; Struyker-Boudier, HA; Van Essen, H | 1 |
| Arnold, JM; Bailey, DG; Munoz, C; Spence, JD | 1 |
| Chayen, R; Rosenthal, T | 1 |
| Littler, WA | 2 |
| Gradman, AH | 1 |
| Ardissino, D; Barberis, P; Mussini, A; Rolla, A; Sardina, M; Savonitto, S; Specchia, G; Zanini, P | 1 |
| Fukuda, Y; Inukai, T; Kuroda, K; Nakao, K | 1 |
| Dong, H; Lu, YQ; Wang, Q; Yang, QQ; Yang, ZC | 1 |
| Cheng, TO | 1 |
| Deussen, A; Guth, BD; Heusch, G | 1 |
| Bäärnhielm, C; Berntsson, P; Brian, WR; Guengerich, FP; Iwasaki, M; Sari, MA | 1 |
| Strauer, BE | 1 |
| Danielson, M; Danielsson, BR; Dencker, L; Regård, CG; Reiland, S; Rundqvist, E | 1 |
| Bengtsson-Hasselgren, B; Blychert, LO; Edgar, B; Raner, S; Rönn, O | 1 |
| Breimer, DD; Cohen, AF; Edgar, B; Johansson, P; Schoemaker, RC; van Hall, MA; van Harten, J; Visser, R | 1 |
| Dahlöf, C; Hjemdahl, P; Kahan, T | 1 |
| Byg-Hansen, J; Mulvany, MJ; Nyborg, NC | 1 |
| Adkins, E; Emmert, S; Ludden, CT; Ribeiro, LG; Seymour, AA; Sweet, CS | 1 |
| Dalaker, K; Prydz, H | 1 |
| Abelardo, NS; Mendoza, VL; Mitchell, MJ; Ramos, EF; Sulit, YQ | 1 |
| Nielsen, SL; Schmidt, JF; Valentin, N | 1 |
| Elmfeldt, D; Hedner, T | 2 |
| Collste, P; Danielsson, M; Elmfeldt, D; Feleke, E; Gelin, A; Hedner, T; Rydén, L | 1 |
| Hansson, BG; Lyngstam, G; Lyngstam, O; Rydén, L; Thilén, U | 1 |
| Houtzagers, JJ; Meulesteen, P; Westermann, B | 1 |
| Eikenburg, DC; Jandhyala, BS; Lokhandwala, MF; Peter, EJ; Steenberg, ML | 1 |
| Littler, WA; Smith, SA | 1 |
| Bisrat, M; Nyström, C | 1 |
| Hoffmann, KJ; Weidolf, L | 2 |
| Di Bona, GF; Ljung, B; Nordlander, M; Thorén, P; Yao, T | 1 |
| Cysouw, KJ; Lamers, JM; Verdouw, PD | 1 |
| Hakim, G; Hrelia, S; Ronca-Testoni, S; Rossi, CA | 1 |
| Bergman, B; Fredholm, BB; Lindström, K | 1 |
| Huysmans, FT; Koene, RA; Sluiter, HE; Thien, TA; van Lier, HJ | 1 |
| Jandhyala, BS | 1 |
| Fossheim, R | 1 |
| Bäärnhielm, C; Hansson, G | 1 |
| Barbieri, L; Camerini, F; Mestroni, L | 1 |
| Bratell, S; Folmerz, P; Hansson, R; Jonsson, O; Lundstam, S; Pettersson, S; Rippe, B; Scherstén, T | 1 |
| Lim, SL; May, PB; Sutter, MC | 1 |
| O'Regan, MH; Phillis, JW; Walter, GA | 1 |
| Ekström, L; Emanuelsson, H; Hjalmarson, A; Jonsteg, C; Schlossman, D | 1 |
| Elmfeldt, D; Hedner, T; Samuelsson, O; Sjögren, E | 1 |
| Hökfelt, B; Hulthén, UL; Katzman, PL | 1 |
| Bengtsson, B; Khan, AR; Weiber, R | 1 |
| Forsén, S; Johnson, JD; Thulin, E; Vogel, HJ; Wittenauer, LA | 1 |
| Friberg, P; Nordlander, M | 1 |
| Bratel, T; Hedenstierna, G; Nyquist, O; Ripe, E | 2 |
| Maclean, D; Mitchell, ET; Readman, AS | 1 |
| Andersson, OK; Granérus, G; Hedner, T | 1 |
| Aberg, H; Lindsjö, M; Mörlin, B | 1 |
| Barbour, MP; Forret, EA; Hill, TW; Lawrie, TD; Lorimer, AR; McAlpine, HM; Rae, AP; Simpson, IA | 1 |
| Emanuelsson, H; Hjalmarson, A; Holmberg, S; Waagstein, F | 2 |
| Littler, WA; Mace, PJ; Stallard, TJ | 2 |
| Hannan, WJ; Muir, AL; Wathen, CG | 1 |
| Hutton, I; Tweddel, AC | 1 |
| Clement, DL; De Pue, NY | 1 |
| Huysmans, FT; Koene, RA; Sluiter, HE; Thien, TA | 1 |
| MacLeod, D; Muir, AL; Tucker, L; Wathen, CG | 1 |
| Bengtsson, B; Edgar, B; Raner, S; Rönn, O | 1 |
| Davidson, JF; Lawrie, TD; Lorimer, AR; McAlpine, HM; Walker, ID | 1 |
| DiBona, GF | 1 |
| Bengtsson, B; Edgar, B; Elmfeldt, D; Lundborg, P; Nyberg, G; Raner, S; Rönn, O | 1 |
| Bolla, G; Boselli, L; Cuspidi, C; Fruscio, M; Gradnik, R; Leonetti, G; Rupoli, L; Sampieri, L; Terzoli, L; Zanchetti, A | 1 |
| Aurell, M; Björck, S; Granérus, G; Herlitz, H | 1 |
| Agner, E; Rehling, M; Trap-Jensen, J | 1 |
| Davies, P; Littler, W; Mace, P; Stallard, T | 1 |
| Hill, TW; Hopkins, RJ | 1 |
| Ljung, B | 1 |
| Jewitt, DE; Timmis, AD | 1 |
| Been, M; Hillis, WS; Macfarlane, PW | 1 |
| Been, M; de Vane, PJ; Hillis, WS; Hornung, RS; Jamieson, RR; Jones, CR; Rae, AP | 1 |
| Culling, W; Sheridan, DJ | 1 |
| Edgar, B; Hoffmann, KJ; Lundborg, P; Regårdh, CG; Rönn, O; Weidolf, L | 1 |
| Nordlander, M | 1 |
| DiBona, GF; Ek, B; Hallbäck-Nordlander, M; Ljung, B; Sjölander, M | 1 |
| Hom, G; Jandhyala, BS; Kivlighn, S | 1 |
| Emanuelsson, H; Holmberg, S | 1 |
| Hom, G; Jandhyala, BS; Kivlighn, SD | 1 |
| Edgar, B; Johansson, L; Johnsson, G; Löfberg, I; Lundborg, P; Regårdh, CG; Rönn, O | 1 |
| Mulvany, MJ; Nyborg, NC | 1 |
| Johnson, JD; Mills, JS | 1 |
| Weidolf, L | 1 |
| Bengtsson, B; Khan, AR | 1 |
| Bailey, BL; Johnson, JD; Mills, JS | 1 |
| Curtis, MJ; Johnston, KM; Macleod, BA; Walker, MJ | 1 |
| Aurell, M; Conradson, T; Herlitz, H | 1 |
| Adelstein, RS; Movsesian, MA | 1 |
| Schwartz, A; Tsai, LI; Wang, T | 1 |
| Hallbäck-Nordlander, MI; Lundin, SA | 1 |
| Minocherhomjee, AE; Roufogalis, BD | 1 |
| Aalkjaer, C; Mulvany, MJ; Petersen, TT | 1 |
| Campbell, S; Jewitt, DE; Kenny, JF; Smyth, P; Timmis, AD | 1 |
| Culling, W; Ruttley, MS; Sheridan, DJ | 1 |
| Campbell, S; Jewitt, DE; Kenny, JF; Kerkez, SA; Smyth, P; Timmis, AD | 1 |
| Ambrose, JM; Dachiw, J; Michalak, RJ; Silver, PJ | 1 |
| Borg, KO; Hoffmann, KJ; Weidolf, L | 1 |
| Bäärnhielm, C; Borg, KO; Skånberg, I | 1 |
| Borg, KO; Carlsson, S; Hoffmann, KJ; Weidolf, L | 1 |
| Adelstein, RS; Movsesian, MA; Swain, AL | 1 |
| De Coster, PM; Detry, JM; Renkin, J | 1 |
| Scheffer, MG; Verdouw, PD; Wolffenbuttel, BH | 1 |
| Hutton, I; Johnsson, G; Murray, RG; Pringle, TH; Tweddel, AC | 1 |
| Dibona, GF; Sawin, LL | 1 |
| Campbell, S; Jewitt, DE; Monaghan, MJ; Timmis, AD; Walker, L | 1 |
| Aberg, H; Andersson, O; Bengtsson, C; Elmfeldt, D; Haglund, K; Hedner, T; Ostman, J; Seideman, P; Sjöberg, KH; Strömgren, E | 1 |
| Arnman, K; Rydén, L; Smedgård, P; Thorhallsson, E | 1 |
| Hutton, I; Johnsson, G; Murray, G; Tweddel, A | 1 |
| Johnson, JD | 1 |
| Johnson, JD; Wittenauer, LA | 1 |
| Verdouw, PD; Wolffenbuttel, BH | 1 |
| Fugman, DA; Johnson, JD | 1 |
| Bostróm, SL; Forsen, S; Ljung, B; Mårdh, S; Thulin, E | 1 |
| Korsgaard, N; Mulvany, MJ; Nyborg, N | 1 |
| Cheng, CP; Little, WC | 1 |
| Leenen, FH; Myers, MG; Tanner, J | 1 |
| Arbus, GS; Balfe, JW; Hebert, D; Koren, G; Moncica, I; Oh, PI; Scolnik, D; ul Qamar, I | 1 |
| Hagiwara, S; Karaki, H; Mitsui, M | 1 |
| Schulte, KL | 1 |
| Abrahamsson, T; Akerblom, B; Nordlander, M; Thalén, P | 1 |
| Boyd, IW | 1 |
| Bergstrand, R; Eriksson, M; Lidman, K; Nyberg, G; Olofsson, B | 1 |
| Cambar, J; L'Azou, B; Lakhdar, B | 1 |
| Koolen, JJ; Piek, J; Swaan, A; van Liebergen, R; Van Wezel, HB; Visser, CA | 1 |
| Huttunen, KR; Knuuttila, ML; Pernu, HE; Tiilikainen, AS | 1 |
| Beyer, T; Brachmann, J; Kübler, W | 1 |
| Cheng, CP; Little, WC; Noda, T; Nordlander, M; Ohno, M | 1 |
| Arnold, JM; Bailey, DG; Spence, JD | 1 |
| Aberg, A; Ekelund, LG; Ulvenstam, G; Walldius, G | 1 |
| Bailey, DG; Carruthers, SG; Edgar, B; Freeman, DJ; Kreeft, JH; Melendez, LJ | 1 |
| Breimer, DD; Cohen, AF; Soons, PA | 1 |
| Breimer, DD; Cohen, AF; Mulders, TM; Schoemaker, HC; Soons, PA; Uchida, E | 1 |
| Ickrath, O; Karsch, KR; Mauser, M; Voelker, W | 1 |
| Ezra, D; Peleg, E; Rosenthal, T; Shamiss, A | 1 |
| Cheng, CP; Elvelin, L; Little, WC; Nordlander, M | 1 |
| Carroll, J; Levi, J; Rosenthal, T; Shamiss, A; Zevin, D | 1 |
| Horwhat, JD; Landry, FJ; Pinski, L; Tomich, D | 1 |
| Falcidieno, M; Mazzotta, G; Ravera, E; Vecchio, C | 1 |
| Daragjati, C; Gustin, G; Taylor, S; White, WB | 1 |
| Armaganijan, D; Batlouni, M; Castro, I; Chaves Junior, Hde C; Leite Luna, R; Nobre, F; Pereira da Cunha, C; Silveira Sbissa, A | 1 |
| Kikuchi, K; Sugawara, H; Tobise, K | 1 |
| Breed, JG; Dees, A; Kremer Hovinga, T; Meems, L; Puister, SM; Verstappen, VM | 1 |
| Marwood, JF; Okoro, EO | 1 |
| Abernethy, DR | 1 |
| Kal, JE; Spaan, JA; Van Wezel, HB; Vergroesen, I | 1 |
| White, CM | 1 |
| Bertocchi, F; Bonaduce, D; Canonico, V; Cavallaro, V; Forgione, L; Ianniciello, A; Petretta, M; Rengo, F | 1 |
| Bossi, M; Tiberti, G | 1 |
| Oonishi, T; Sakashita, K; Uyesaka, N | 1 |
| Gillett, C; Golston, AG; Heckbert, SR; Kaplan, RC; Kriesel, D; Psaty, BM; Smith, NL | 1 |
| Archambault, F; Jewell, D; Lacourcière, Y; Lefebvre, J; Poirier, L; Reed, CV | 1 |
| Bohm, R; Erley, CM; Koch, HH; Nast, HP; Risler, T; Stein, G; Wetzchewald, D | 1 |
| Seibold, JR; Sturgill, MG | 1 |
| Gong, QY; Shi, NC; Yang, ZC; Zheng, P | 1 |
| Cobeta, JC; Navarro, N; Pina Latorre, MA; Rodilla, F; Zabala, S | 1 |
| Kerc, J; Knez, Z; Sencar-Bozic, P; Srcic, S | 1 |
| Abrahamsson, B; Roos, K; Sjögren, J | 1 |
| Ahlman, H; Jodal, M; Lundgren, O; Peregrin, AT | 1 |
| Jaroszkiewicz, E; Marciniec, B; Ogrodowczyk, M; Patterson, LH; Taiwo, FA | 1 |
| Marley, J; Taverner, D; Tonkin, AL | 1 |
| Nakamoto, H; Okada, H; Shouda, J; Sugahara, S; Suzuki, H | 1 |
| Beckey, NP; Korman, L; Parra, D | 1 |
| Arbus, GS; Blowey, D; Khattak, S; Koren, G; Lyszkiewicz, DA; Rogan, JW | 1 |
| Ameriso, S; Fischberg, GM; Fisher, MJ; Lozano, E; Rajamani, K | 1 |
| Mielcarek, J | 1 |
| Faulkner, M; Hilleman, DE; Reyes, AP; Wurdeman, RL | 1 |
| Koopmans, RP; Pfaffendorf, M; van der Lee, R; van Lieshout, JJ; van Montfrans, GA; van Zwieten, PA | 1 |
| Florea, S; Raicu, M | 1 |
| Joyner, CD; Leenen, FH; Myers, MG; Toal, CB | 1 |
| Clarke, SE; Galetin, A; Houston, JB | 1 |
| Camargo, C; Núñez-Vergara, LJ; Ortiz, ME; Squella, JA | 1 |
| Arvola, P; Nordback, I; Sand, J | 1 |
| Chen, CH; Ho, HO; Sheu, MT; Wang, GM; Wang, SS | 1 |
| Kvetina, J; Macek, K; Mejstríková, L; Pastera, J; Zoulová, J | 1 |
| Konno, H; Marsac, PJ; Taylor, LS | 1 |
| Marsac, PJ; Shamblin, SL; Taylor, LS | 1 |
| Mielcarek, J; Naskrent, M | 1 |
| Sahney, S | 1 |
| Konno, H; Marsac, PJ; Rumondor, AC; Taylor, LS | 1 |
| Chamarthy, SP; Mao, C; Pinal, R | 1 |
| Alonzo, DE; Bates, S; Ivanisevic, I; Rumondor, AC; Taylor, LS | 1 |
| Foti, RS; Rock, DA; Wahlstrom, JL; Wienkers, LC | 1 |
| Choi, DS; Chokshi, H; Hu, Q; Sandhu, H; Shah, N | 1 |
| de Ridder, GG; Maddala, R; Nagendran, T; Rao, PV; Schey, KL | 1 |
| Alonzo, DE; Catron, ND; Gao, Y; Raina, SA; Taylor, LS; Wu, J; Zhang, GGZ; Zhu, D | 1 |
| Chen, W; Fang, H; Liu, X; Xu, W | 1 |
| Ishigai, M; Kato, M; Mitsui, T; Miyake, T; Nagao, S; Nemoto, T; Ogawa, K; Yamada, H | 1 |
| Alonzo, DE; Catron, ND; Gao, Y; Raina, SA; Taylor, LS; Wu, J; Zhang, GG; Zhu, D | 1 |
| Affouard, F; Gerges, J | 1 |
| de Souza, RC; Ferreira, DC; Fischer, RG; Gonçalves, LS; Vidal, F | 1 |
| Ben Osman, Y; Liavitskaya, T; Vyazovkin, S | 1 |
| Munson, EJ; Sarpal, K | 1 |
| Chen, WC; Chia-Hui Tan, E; Chiang, TY; Shen, CC; Ueng, YF; Wang, HJ | 1 |
11 review(s) available for nifedipine and felodipine
| Article | Year |
|---|---|
Property-based design: optimization of drug absorption and pharmacokinetics.
Topics: Animals; Biological Transport; Blood Proteins; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane; Drug Design; Eye; Humans; Intestinal Absorption; Models, Biological; Models, Molecular; Nasal Mucosa; Pharmaceutical Preparations; Pharmacokinetics; Prodrugs; Skin Absorption | 2001 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Prevention of alpha-adrenergic coronary constriction by calcium-antagonists.
Topics: Animals; Calcium Channel Blockers; Constriction, Pathologic; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Felodipine; Nifedipine; Receptors, Adrenergic, alpha; Vasoconstriction | 1990 |
Antihypertensive agents--the race for third place.
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Captopril; Diazoxide; Felodipine; Humans; Hydralazine; Indoramin; Labetalol; Minoxidil; Nicardipine; Nifedipine; Vasodilator Agents; Verapamil | 1985 |
[Calcium antagonists in congestive heart failure].
Topics: Calcium Channel Blockers; Cardiomyopathy, Dilated; Diltiazem; Felodipine; Heart Failure; Hemodynamics; Humans; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Verapamil | 1988 |
Vascular versus myocardial effects of calcium antagonists.
Topics: Amlodipine; Animals; Dogs; Felodipine; Heart Failure; Hemodynamics; Humans; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Pressoreceptors; Ventricular Function, Left | 1994 |
Grapefruit juice and drugs. How significant is the interaction?
Topics: Beverages; Biological Availability; Citrus; Dihydropyridines; Drug Interactions; Felodipine; Flavanones; Flavonoids; Half-Life; Humans; Nifedipine; Nitrendipine | 1994 |
Vascular selective calcium entry blockers in the treatment of cardiovascular disorders: focus on felodipine.
Topics: Amlodipine; Calcium Channel Blockers; Coronary Disease; Felodipine; Heart Failure; Hemodynamics; Humans; Hypertension; Myocardial Contraction; Nifedipine; Vasodilation | 1995 |
Grapefruits and drugs: when is statistically significant clinically significant?
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Beverages; Citrus; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Humans; Metabolic Clearance Rate; Nifedipine; Oxidoreductases, N-Demethylating; Pharmacokinetics; Smoking | 1997 |
Calcium channel blockers in left ventricular dysfunction or congestive heart failure.
Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Felodipine; Heart Failure; Humans; Nicardipine; Nifedipine; Ventricular Dysfunction, Left; Verapamil | 1997 |
A review of calcium channel antagonists in the treatment of pediatric hypertension.
Topics: Amiodarone; Calcium Channel Blockers; Child; Felodipine; Humans; Hypertension; Isradipine; Nicardipine; Nifedipine; Verapamil | 2006 |
50 trial(s) available for nifedipine and felodipine
| Article | Year |
|---|---|
Interaction of citrus juices with felodipine and nifedipine.
Topics: Biological Availability; Blood Pressure; Citrus; Drug Interactions; Evaluation Studies as Topic; Felodipine; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1991 |
Comparison of felodipine with nifedipine as additions to metoprolol in the treatment of hypertension. U.K. Multicentre Hospital Group.
Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Felodipine; Heart Rate; Humans; Hypertension; Metoprolol; Middle Aged; Nifedipine; Randomized Controlled Trials as Topic | 1990 |
Felodipine (once daily) versus nifedipine (four times daily) for Prinzmetal's angina pectoris.
Topics: Angina Pectoris, Variant; Coronary Angiography; Coronary Disease; Double-Blind Method; Electrocardiography, Ambulatory; Felodipine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifedipine; Placebos; Time Factors | 1991 |
Control of blood pressure in hypertensive patients with felodipine extended release or nifedipine retard.
Topics: Adult; Aged; Blood Pressure; Delayed-Action Preparations; Double-Blind Method; Drug Evaluation; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1990 |
Acute effects of felodipine and nifedipine on hepatic and forearm blood flow in healthy men.
Topics: Adult; Blood Pressure; Double-Blind Method; Felodipine; Forearm; Heart Rate; Humans; Liver Circulation; Male; Nifedipine; Regional Blood Flow | 1990 |
A comparison of felodipine and nifedipine as monotherapies for the treatment of mild to moderate hypertension.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine | 1989 |
The clinical effect of felodipine and nifedipine in Raynaud's phenomenon.
Topics: Adolescent; Adult; Child; Child, Preschool; Double-Blind Method; Felodipine; Female; Humans; Infant; Male; Nifedipine; Randomized Controlled Trials as Topic; Raynaud Disease | 1989 |
Antihypertensive effects of felodipine compared with placebo.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuretics; Drug Therapy, Combination; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Time Factors | 1985 |
Antihypertensive effect of felodipine combined with beta-blockade. A comparison between 2 and 3 daily dosages.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Felodipine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Random Allocation | 1985 |
Felodipine in comparison with prazosin in hypertensive patients inadequately controlled on beta-blockade.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Prazosin; Quinazolines | 1985 |
Felodipine vs hydralazine: a controlled trial as third line therapy in hypertension. Cooperative Study Group.
Topics: Adult; Aged; Antihypertensive Agents; Double-Blind Method; Felodipine; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; Nifedipine; Random Allocation | 1986 |
Haemodynamic, hormonal, and diuretic effects of felodipine in healthy normotensive volunteers.
Topics: Adrenocorticotropic Hormone; Adult; Antihypertensive Agents; Blood Pressure; Diuresis; Electrolytes; Felodipine; Heart Rate; Hemodynamics; Hormones; Humans; Male; Nifedipine; Renin | 1985 |
Felodipine-induced dilatation of epicardial coronary arteries. A randomized, double-blind study.
Topics: Adult; Aged; Blood Pressure; Catecholamines; Clinical Trials as Topic; Coronary Vessels; Double-Blind Method; Felodipine; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Random Allocation; Vasodilation | 1986 |
Treatment of essential hypertension with felodipine in combination with a diuretic.
Topics: Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Therapy, Combination; Felodipine; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Norepinephrine; Time Factors | 1986 |
Comparative trial of felodipine and nifedipine in refractory hypertension.
Topics: Aged; Ankle; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Random Allocation; Time Factors | 1985 |
Effects of felodipine on rest and exercise heart rate and blood pressure in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Nifedipine; Physical Exertion; Random Allocation | 1985 |
Acute haemodynamic effects of felodipine in congestive heart failure.
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Felodipine; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Pulmonary Wedge Pressure; Stroke Volume; Time Factors | 1985 |
Felodipine in hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Norepinephrine; Posture; Renin; Time Factors; Vasodilator Agents | 1985 |
Acute haemodynamic effects of felodipine and verapamil in man, singly and with metoprolol.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Felodipine; Heart Rate; Hemodynamics; Humans; Male; Metoprolol; Nifedipine; Regional Blood Flow; Stroke Volume; Vascular Resistance; Verapamil | 1985 |
Acute diuretic/natriuretic properties of felodipine in man.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diuresis; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Natriuresis; Nifedipine; Renal Circulation; Time Factors | 1985 |
Effect of felodipine on blood pressure, heart rate, forearm blood flow and the response to venous occlusion in normal man.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Felodipine; Forearm; Heart Rate; Humans; Male; Nifedipine; Regional Blood Flow; Vascular Resistance | 1985 |
Effects of felodipine on red blood cell deformability.
Topics: Adolescent; Adult; Antihypertensive Agents; Erythrocyte Count; Erythrocyte Deformability; Felodipine; Humans; In Vitro Techniques; Nifedipine; Physical Exertion | 1985 |
Felodipine kinetics in healthy men.
Topics: Administration, Oral; Adult; Feces; Felodipine; Half-Life; Humans; Infusions, Parenteral; Intestinal Absorption; Kinetics; Male; Models, Biological; Nifedipine; Random Allocation; Solutions | 1985 |
The effect of felodipine on forearm haemodynamics and the myogenic response of the forearm resistance vessels in normal man.
Topics: Adult; Blood Pressure; Felodipine; Forearm; Heart Rate; Humans; Male; Nifedipine; Regional Blood Flow; Time Factors; Vascular Resistance | 1985 |
Felodipine--a new vasodilator, in addition to beta-receptor blockade in hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Felodipine; Female; Heart Rate; Humans; Kinetics; Male; Middle Aged; Nifedipine; Random Allocation; Vasodilator Agents | 1983 |
Differential effects of felodipine and nifedipine on 24-h blood pressure and left ventricular mass.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Double-Blind Method; Echocardiography; Electrocardiography; Felodipine; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nifedipine | 1995 |
A crossover comparison of extended release felodipine with prolonged action nifedipine in hypertension.
Topics: Adolescent; Antihypertensive Agents; Child; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Felodipine; Humans; Hypertension, Renal; Nifedipine; Patient Compliance | 1995 |
24 h anti-anginal and anti-ischaemic effects with once daily felodipine. A double-blind comparison with nifedipine, twice daily, and placebo in patients with stable exercise induced angina pectoris.
Topics: Administration, Oral; Adult; Aged; Angina Pectoris, Variant; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Electrocardiography; Exercise Test; Felodipine; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine | 1995 |
Aiming for steady 24-hour plasma concentrations: a comparison of two calcium antagonist and beta-blocker combinations.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Chromatography, Gas; Chromatography, Liquid; Delayed-Action Preparations; Drug Combinations; Electrocardiography; Felodipine; Humans; Male; Metoprolol; Nifedipine | 1993 |
Effects of intracoronary felodipine versus nifedipine on left ventricular contractility and coronary sinus blood flow in stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Coronary Circulation; Coronary Vessels; Felodipine; Humans; Injections, Intra-Arterial; Male; Middle Aged; Myocardial Contraction; Nifedipine; Vasodilation; Ventricular Function, Left | 1994 |
Effects of felodipine versus nifedipine on exercise tolerance in stable angina pectoris.
Topics: Analysis of Variance; Angina Pectoris; Blood Pressure; Double-Blind Method; Exercise; Felodipine; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine | 1994 |
Quinidine interaction with nifedipine and felodipine: pharmacokinetic and pharmacodynamic evaluation.
Topics: Adolescent; Adult; Analysis of Variance; Blood Pressure; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Double-Blind Method; Drug Interactions; Felodipine; Heart Rate; Humans; Male; Nifedipine; Quinidine; Reference Values; Regression Analysis | 1993 |
Comparative effects of felodipine, nitrendipine and nifedipine in healthy subjects: concentration-effect relationships of racemic drugs and enantiomers.
Topics: Adult; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Felodipine; Heart Rate; Hemodynamics; Humans; Male; Nifedipine; Nitrendipine; Protein Binding; Stereoisomerism | 1993 |
Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics.
Topics: Administration, Oral; Adult; Blood Proteins; Double-Blind Method; Felodipine; Half-Life; Humans; Male; Nifedipine; Nitrendipine; Pyridines; Stereoisomerism | 1993 |
[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease].
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Disease; Electrocardiography; Exercise Test; Felodipine; Female; Hemodynamics; Humans; Infusions, Intravenous; Isradipine; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Nifedipine; Nisoldipine | 1993 |
The role of atrial natriuretic peptide in the diuretic effect of Ca2+ entry blockers.
Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Calcium Channel Blockers; Diuretics; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Natriuresis; Nifedipine; Renin; Renin-Angiotensin System; Verapamil | 1993 |
Twenty-four-hour blood pressure monitoring during treatment with extended-release felodipine versus slow-release nifedipine: cross-over study.
Topics: Adolescent; Adult; Aged; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Felodipine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1995 |
Felodipine as an alternative to more expensive calcium antagonists in mild to moderate hypertension.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Drug Costs; Felodipine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Prospective Studies; Treatment Outcome | 1996 |
[Efficacy and tolerability of felodipine and nifedipine in stable angina refractory to beta-blocker therapy].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Felodipine; Humans; Male; Middle Aged; Nifedipine; Placebos; Stroke Volume; Vasodilator Agents | 1996 |
[Multicenter comparative study of felodipine-ER and nifedipine-OROS in the treatment of mild-to-moderate arterial hypertension].
Topics: Adult; Aged; Analysis of Variance; Chi-Square Distribution; Drug Tolerance; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1996 |
Calcium antagonists, a useful additional therapy in treatment resistant hypertension: comparison of felodipine ER and nifedipine Retard by 24-h ambulatory blood pressure monitoring.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Double-Blind Method; Drug Tolerance; Felodipine; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Nifedipine; Treatment Outcome | 1997 |
Myocardial oxygen supply:demand ratio as reference for coronary vasodilatory drug effects in humans.
Topics: Aged; Cardiac Catheterization; Cardiac Pacing, Artificial; Coronary Artery Bypass; Coronary Circulation; Coronary Disease; Felodipine; Female; Humans; Male; Middle Aged; Myocardium; Nifedipine; Nitroprusside; Oxygen Consumption; Piperazines; Prospective Studies; Reference Values; Vasodilator Agents | 1997 |
Twenty-four-hour blood pressure monitoring during treatment with extended-release felodipine versus slow-release nifedipine in elderly patients with mild to moderate hypertension: a randomized, double-blind, cross-over study.
Topics: Aged; Aged, 80 and over; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Felodipine; Female; Humans; Hypertension; Male; Nifedipine | 1997 |
Comparative effects of felodipine ER, amlodipine and nifedipine GITS on 24 h blood pressure control and trough to peak ratios in mild to moderate ambulatory hypertension: a forced titration study.
Topics: Adult; Aged; Amlodipine; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Delayed-Action Preparations; Felodipine; Female; Follow-Up Studies; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Outpatients; Treatment Outcome | 1998 |
A comparison of the antihypertensive efficacy and safety of felodipine IV and nifedipine IV in patients with hypertensive crisis or emergency not responding to oral nifedipine.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Emergencies; Felodipine; Female; Heart Rate; Humans; Hypertension; Injections, Intravenous; Male; Middle Aged; Nifedipine | 1998 |
Cross-over comparison of nifedipine Oros and felodipine extended release with blind 24 h ambulatory blood pressure assessments.
Topics: Adolescent; Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Felodipine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Single-Blind Method; Vasodilator Agents | 1999 |
A randomized prospective crossover trial of amlodipine in pediatric hypertension.
Topics: Adolescent; Amlodipine; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Child; Cross-Over Studies; Felodipine; Female; Humans; Hypertension; Male; Nifedipine; Patient Compliance; Prospective Studies | 2000 |
Comparison of the time courses and potencies of the vasodilator effects of nifedipine and felodipine in the human forearm.
Topics: Adolescent; Adult; Brachial Artery; Calcium Channel Blockers; Felodipine; Forearm; Hemodynamics; Humans; Kinetics; Male; Nifedipine; Plethysmography; Therapeutic Equivalency; Vasodilation; Vasodilator Agents | 2001 |
Differential effects of once-daily antihypertensive drugs on blood pressure, left ventricular mass and sympathetic activity: Nifedipine-GITS versus felodipine-ER versus enalapril.
Topics: Antihypertensive Agents; Biomarkers; Blood Pressure; Data Interpretation, Statistical; Enalapril; Felodipine; Female; Heart Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nifedipine; Norepinephrine; Placebo Effect; Single-Blind Method | 2002 |
The efficacy and safety of arotinolol combined with a different calcium channel blocker in the treatment of Chinese patients with essential hypertension: a one-year follow-up study.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Asian People; Blood Pressure; Calcium Channel Blockers; China; Circadian Rhythm; Drug Therapy, Combination; Essential Hypertension; Felodipine; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Nifedipine; Propanolamines; Treatment Outcome | 2014 |
175 other study(ies) available for nifedipine and felodipine
| Article | Year |
|---|---|
Long-acting dihydropyridine calcium antagonists. 6. Structure-activity relationships around 4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-2-[(2-hydroxyethoxy)methyl]-5 -(methoxycarbonyl)-6-methyl-1,4-dihydropyridine.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Heart Rate; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship | 1991 |
Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Time Factors; Vasodilator Agents | 1990 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents.
Topics: Amlodipine; Animals; Biological Assay; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; Guinea Pigs; Hemodynamics; Kinetics; Male; Nifedipine; Pyridines; Rats; Vasoconstriction | 1986 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results | 2006 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Antihypertensive and antiarrhythmic properties of a para-hydroxy[bis(ortho-morpholinylmethyl)]phenyl-1,4-DHP compound: comparison with other compounds of the same kind and relationship with logP values.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Heart Rate; Male; Morpholines; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.
Topics: Carboxylic Acids; Cytochrome P-450 Enzyme System; Esters; Humans; Hydrolysis; Microsomes; Models, Molecular; Molecular Structure; Prodrugs; Quantum Theory; Signal Transduction | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Substrate Specificity | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Treatment of hypertension induces a fall in platelet basal cytoplasmic calcium concentration without influencing platelet aggregation.
Topics: Adult; Aged; Basal Metabolism; Blood Platelets; Blood Pressure; Calcium; Cytoplasm; Drug Therapy, Combination; Felodipine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Platelet Aggregation; Sensitivity and Specificity | 1992 |
Modulation of the Ca2+ channel voltage sensor and excitation-contraction coupling by silver.
Topics: Animals; Biophysical Phenomena; Biophysics; Calcium Channels; Electrochemistry; Felodipine; In Vitro Techniques; Muscle Contraction; Muscles; Nifedipine; Rana catesbeiana; Rana temporaria; Silver; Sulfhydryl Compounds | 1992 |
Silver-induced frog skeletal muscle contraction and its modulation by calcium antagonists nifedipine and felodipine and calcium agonist Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Drug Interactions; Felodipine; In Vitro Techniques; Muscle Contraction; Muscles; Nifedipine; Rana temporaria; Silver | 1992 |
Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet.
Topics: Animals; Blood; Calcium; Clofibrate; Dietary Fats; Diltiazem; Felodipine; Lipids; Male; Nifedipine; Nimodipine; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice.
Topics: Adult; Aged; Animals; Beverages; Citrus; Dihydropyridines; Felodipine; Flavanones; Flavonoids; Humans; Male; Microsomes, Liver; Middle Aged; Nifedipine; Quercetin; Rats; Rats, Inbred Strains; Stereoisomerism | 1992 |
Microvascular actions of calcium channel antagonists.
Topics: Animals; Arterioles; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Felodipine; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Inbred SHR; Vasoconstriction; Vasodilation; Venules; Verapamil | 1991 |
Interaction of citrus juices with felodipine and nifedipine.
Topics: Beverages; Biological Availability; Citrus; Drug Interactions; Felodipine; Humans; Nifedipine | 1991 |
Hemodynamic effects of the vascular selective calcium antagonist felodipine in patients with impaired left ventricular function.
Topics: Coronary Disease; Felodipine; Heart Failure; Hemodynamics; Humans; Hypertension; Myocardial Contraction; Myocardium; Nifedipine; Ventricular Function, Left | 1992 |
Effects of felodipine on vascular smooth muscle in comparison with nifedipine.
Topics: Animals; Aorta, Thoracic; Caffeine; Calcium; Felodipine; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Sarcolemma | 1991 |
Antagonistic effects of dihydropyridines and verapamil on CaCl2 and 5-HT-evoked contraction in porcine coronary artery.
Topics: Animals; Calcium Chloride; Coronary Vessels; Dihydropyridines; Felodipine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Nimodipine; Serotonin Antagonists; Swine; Verapamil | 1991 |
All calcium channel blockers are not alike.
Topics: Amlodipine; Calcium Channel Blockers; Diltiazem; Felodipine; Heart Failure; Humans; Nifedipine | 1991 |
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme System; Dihydropyridines; Felodipine; Humans; Kinetics; Microsomes, Liver; Nifedipine; Norpregnenes; Oxidation-Reduction | 1991 |
Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure.
Topics: Adult; Animals; Cardiac Output, Low; Cardiomegaly; Coronary Circulation; Coronary Disease; Coronary Vessels; Felodipine; Humans; Hydralazine; Hypertension; Metoprolol; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance | 1990 |
Histological and in vitro studies supporting decreased uteroplacental blood flow as explanation for digital defects after administration of vasodilators.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Extremities; Felodipine; Female; In Vitro Techniques; Limb Deformities, Congenital; Maternal-Fetal Exchange; Nifedipine; Nitrendipine; Placenta; Pregnancy; Rabbits; Vasodilator Agents | 1990 |
The influence of infusion rate on the hemodynamic effects of felodipine.
Topics: Adult; Blood Pressure; Electrocardiography; Fasting; Felodipine; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Male; Mathematics; Metabolic Clearance Rate; Nifedipine | 1990 |
Influence of acetylcholine, peptides, and other vasodilators on endogenous noradrenaline overflow and vasoconstriction in canine blood perfused gracilis muscle.
Topics: Acetylcholine; Animals; Atropine; Dogs; Felodipine; Female; Male; Muscles; Neuromuscular Junction; Nifedipine; Nitroglycerin; Norepinephrine; Perfusion; Regional Blood Flow; Substance P; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilator Agents | 1985 |
Effect of felodipine on resistance vessels from spontaneously hypertensive and normotensive rats.
Topics: Animals; Calcium; Felodipine; Hypertension; Muscle Contraction; Nifedipine; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Splanchnic Circulation; Vascular Resistance; Vasomotor System | 1985 |
Enalapril in experimental hypertension and acute heart failure: comparison with calcium channel blockers.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Dogs; Drug Therapy, Combination; Enalapril; Enalaprilat; Felodipine; Heart; Heart Failure; Hypertension; Lisinopril; Male; Nifedipine; Nitrendipine; Rats; Rats, Inbred SHR | 1986 |
Effect of some drugs on thromboplastin activity in mouse trophoblast cells in vitro and in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Animals; Calcium Channel Blockers; Dinoprostone; Felodipine; Female; Gallic Acid; Methylation; Mice; Monensin; Nifedipine; Nitrendipine; Pregnancy; Prostaglandins E; Thromboplastin; Trophoblasts; Tubercidin; Verapamil | 1986 |
Long term experience of felodipine in combination with beta-blockade and diuretics in refractory hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Alkaline Phosphatase; Antihypertensive Agents; Aspartate Aminotransferases; Blood Pressure; Blood Sedimentation; Diuretics; Drug Therapy, Combination; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Time Factors | 1985 |
Influence of felodipine and verapamil on the sympathetic transmitter release and on the pre- and post-junctional effects of exogenous noradrenaline in the perfused rat kidney.
Topics: Animals; Antihypertensive Agents; Cocaine; Electric Stimulation; Felodipine; In Vitro Techniques; Kidney; Male; Neuromuscular Junction; Neurotransmitter Agents; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Verapamil | 1985 |
Coulter Counter measurements of solubility and dissolution rate of sparingly soluble compounds using micellar solutions.
Topics: Felodipine; Griseofulvin; Kinetics; Micelles; Nifedipine; Particle Size; Solubility; Surface Properties | 1986 |
Identification of felodipine metabolites in rat urine.
Topics: Animals; Antihypertensive Agents; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Felodipine; Gas Chromatography-Mass Spectrometry; Male; Nifedipine; Rats; Rats, Inbred Strains | 1985 |
Renal and cardiovascular effects of acute and chronic administration of felodipine to SHR.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Felodipine; Furosemide; Heart Rate; Hemodynamics; Kidney; Male; Minoxidil; Nifedipine; Rats; Rats, Inbred SHR; Renal Circulation; Sodium; Sympathetic Nervous System | 1985 |
Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase.
Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Felodipine; In Vitro Techniques; Myocardium; Nifedipine; Phosphodiesterase Inhibitors; Prenylamine; Pyrrolidines; Sarcolemma; Swine | 1985 |
Interaction of smooth muscle relaxant drugs with calmodulin and cyclic nucleotide phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Bromides; Calcium; Calmodulin; Cyclic Nucleotide Phosphodiesterases, Type 1; Enzyme Activation; Felodipine; Fendiline; Nifedipine; Papaverine; Parasympatholytics; Spectrometry, Fluorescence; Trifluoperazine | 1985 |
Actions of enprofylline in the rat hippocampus.
Topics: Adenosine; Animals; Bronchodilator Agents; Cyclic AMP; Evoked Potentials; Felodipine; Hippocampus; Isoproterenol; Male; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline; Trifluoperazine; Xanthines | 1985 |
Studies on the effects of felodipine on the vascular resistance and reactivity in pentobarbital anesthetized dogs.
Topics: Angiotensin II; Animals; Blood Pressure; Calcium Channel Blockers; Denervation; Dogs; Extremities; Felodipine; Female; Imidazoles; Male; Nifedipine; Norepinephrine; Pentobarbital; Phenylephrine; Receptors, Adrenergic, alpha; Vascular Resistance; Vasoconstriction | 1985 |
Crystal structure of the dihydropyridine Ca2+ antagonist felodipine. Dihydropyridine binding prerequisites assessed from crystallographic data.
Topics: Calcium Channel Blockers; Calcium Channels; Felodipine; Hydrogen Bonding; Molecular Conformation; Nifedipine; Receptors, Nicotinic; Structure-Activity Relationship; Vasodilator Agents; X-Ray Diffraction | 1986 |
Oxidation of 1,4-dihydropyridines by prostaglandin synthase and the peroxidic function of cytochrome P-450. Demonstration of a free radical intermediate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cytochrome P-450 Enzyme System; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Free Radicals; Glutathione; In Vitro Techniques; Male; Microsomes; Nifedipine; Oxidation-Reduction; Oxygen Consumption; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred Strains | 1986 |
Effects of oxygen free radical scavengers, xanthine oxidase inhibition and calcium entry-blockers on leakage of albumin after ischaemia. An experimental study in rabbit kidneys.
Topics: Allopurinol; Animals; Calcium Channel Blockers; Capillary Permeability; Catalase; Felodipine; Free Radicals; Ischemia; Kidney; Mannitol; Nifedipine; Nitrendipine; Oxygen; Rabbits; Serum Albumin, Radio-Iodinated; Superoxide Dismutase; Xanthine Oxidase | 1988 |
Manganese can inhibit or potentiate contractile responses in mesenteric portal vein.
Topics: Animals; Barium; Calcium; Felodipine; Gallopamil; In Vitro Techniques; Male; Manganese; Mesenteric Veins; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Spectrophotometry, Atomic; Strontium; Tissue Distribution; Verapamil | 1988 |
Effects of nifedipine and felodipine on adenosine and inosine release from the hypoxemic rat cerebral cortex.
Topics: Adenosine; Animals; Cerebral Cortex; Felodipine; Hypoxia, Brain; Inosine; Male; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains | 1988 |
The effect of 8 weeks treatment with the calcium antagonist felodipine on blood pressure, heart rate, working capacity, plasma renin activity, plasma angiotensin II, urinary catecholamines and aldosterone in patients with essential hypertension.
Topics: Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Catecholamines; Felodipine; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Physical Exertion; Renin | 1986 |
Low potency of Ca antagonists in smooth muscle from different levels of the respiratory tract.
Topics: Animals; Bronchi; Calcium Channel Blockers; Felodipine; Female; Gallopamil; Guinea Pigs; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Respiratory Muscles; Trachea; Verapamil | 1987 |
Localization of a felodipine (dihydropyridine) binding site on calmodulin.
Topics: Animals; Antihypertensive Agents; Binding Sites; Calcium; Calmodulin; Cattle; Felodipine; Kinetics; Male; Nifedipine; Peptide Fragments; Protein Binding; Testis; Trypsin | 1986 |
Influence of long-term antihypertensive therapy on cardiac function, coronary flow and myocardial oxygen consumption in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Felodipine; Heart; Heart Rate; Hypertension; Male; Metoprolol; Myocardium; Nifedipine; Oxygen Consumption; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke Volume; Time Factors; Vascular Resistance | 1986 |
Long-term treatment with a new calcium antagonist, felodipine, in chronic obstructive lung disease.
Topics: Calcium Channel Blockers; Dose-Response Relationship, Drug; Exercise Test; Felodipine; Humans; Hypertension, Pulmonary; Lung Diseases, Obstructive; Nifedipine; Physical Exertion; Pulmonary Gas Exchange; Stroke Volume; Time Factors; Vascular Resistance; Ventilation-Perfusion Ratio | 1986 |
Felodipine compared to nifedipine as "third-line drug" in resistant hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Drug Evaluation; Drug Resistance; Felodipine; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine; Time Factors | 1986 |
Felodipine. A calcium-inhibiting vasodilator in refractory hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Felodipine; Female; Glomerular Filtration Rate; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Renal Circulation; Renin | 1985 |
Effects of felodipine on resistance and capacitance vessels in patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Blood Vessels; Electrocardiography; Felodipine; Heart Rate; Humans; Hydralazine; Hypertension; Middle Aged; Nifedipine; Nitroglycerin; Stroke Volume; Vascular Resistance | 1985 |
Felodipine in ventricular dysfunction.
Topics: Adult; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Disease; Exercise Test; Felodipine; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Vasodilator Agents | 1986 |
First International Meeting on Felodipine. Proceedings of an international symposium. Montreux, Switzerland, 16-17 June 1984.
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Felodipine; Humans; Nifedipine | 1985 |
Effect of felodipine and metoprolol on muscle and skin arteries in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Heart Rate; Humans; Hyperemia; Hypertension; Male; Metoprolol; Middle Aged; Muscle, Smooth, Vascular; Muscles; Nifedipine; Physical Exertion; Posture; Regional Blood Flow; Skin; Vascular Resistance | 1985 |
Haemodynamic effects of intravenous felodipine in normotensive and hypertensive subjects.
Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Norepinephrine; Regional Blood Flow; Time Factors; Vascular Resistance | 1985 |
Felodipine as an alternative to minoxidil in severe refractory hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Drug Resistance; Felodipine; Humans; Hypertension; Male; Middle Aged; Minoxidil; Nifedipine; Pyrimidines | 1985 |
Acute haemodynamic and platelet effects of felodipine in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Blood Coagulation; Blood Platelets; Blood Pressure; Felodipine; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Middle Aged; Nifedipine; Platelet Aggregation; Time Factors | 1985 |
Effects of felodipine on renal function in animals.
Topics: Animals; Antihypertensive Agents; Dogs; Felodipine; Glomerular Filtration Rate; Hemodynamics; Hydralazine; Hypertension; Kidney; Nifedipine; Potassium; Rats; Rats, Inbred SHR; Renal Circulation; Sodium | 1985 |
Antihypertensive and water and sodium balance effects of felodipine, a new vasodilating calcium antagonist, in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Creatinine; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Nifedipine; Sodium; Vasodilator Agents; Water-Electrolyte Balance | 1985 |
Renal effects of felodipine in hypertensive patients with reduced renal function.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertension, Renal; Hypertension, Renovascular; Kidney; Male; Middle Aged; Nifedipine; Time Factors | 1985 |
Haemodynamic effects of single-dose felodipine in normal man.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Output; Catecholamines; Electrocardiography; Felodipine; Heart Rate; Hemodynamics; Humans; Kinetics; Liver Circulation; Male; Nifedipine; Regional Blood Flow; Stroke Volume; Vascular Resistance | 1985 |
Vascular selectivity of felodipine.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dogs; Felodipine; Heart; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Rats; Rats, Inbred Strains; Species Specificity; Vascular Resistance | 1985 |
Studies with felodipine in congestive heart failure.
Topics: Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Echocardiography; Felodipine; Heart Failure; Hemodynamics; Humans; Middle Aged; Myocardium; Nifedipine; Oxygen Consumption; Physical Exertion; Posture | 1985 |
Electrophysiological effects of felodipine.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Electrophysiology; Felodipine; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Sinoatrial Node | 1985 |
Electrophysiological effects of felodipine in combination with metoprolol.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Drug Synergism; Electrocardiography; Electrophysiology; Felodipine; Female; Heart Conduction System; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Nifedipine; Purkinje Fibers; Vasodilator Agents | 1985 |
Acute haemodynamic effects of felodipine in patients with coronary artery disease.
Topics: Antihypertensive Agents; Cardiac Catheterization; Coronary Disease; Felodipine; Heart Rate; Hemodynamics; Humans; Nifedipine; Regional Blood Flow; Sinoatrial Node; Vascular Resistance | 1985 |
Absorption, distribution and elimination of felodipine in man.
Topics: Adult; Antihypertensive Agents; Biotransformation; Feces; Felodipine; Half-Life; Humans; Infusions, Parenteral; Injections, Intravenous; Intestinal Absorption; Male; Nifedipine; Protein Binding; Tissue Distribution | 1985 |
Haemodynamic effects of short and long term administration of felodipine in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Cardiac Output; Coronary Circulation; Drug Administration Schedule; Felodipine; Female; Heart Rate; Hemodynamics; Hydralazine; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex; Regional Blood Flow; Stroke Volume; Time Factors | 1985 |
Effect of felodipine on renal hemodynamics and excretion in the dog.
Topics: Animals; Antihypertensive Agents; Dogs; Electrolytes; Felodipine; Glomerular Filtration Rate; Hemodynamics; Kidney; Male; Nifedipine; Renal Circulation | 1985 |
Studies on the role of intracellular sodium and calcium in the central regulation of arterial pressure.
Topics: Angiotensin II; Animals; Blood Pressure; Calcium; Central Nervous System; Dogs; Felodipine; Nifedipine; Ouabain; Sodium | 1985 |
No adverse effects from high doses of felodipine to patients with coronary heart disease.
Topics: Coronary Circulation; Coronary Disease; Felodipine; Hemodynamics; Humans; Lactates; Lactic Acid; Male; Middle Aged; Myocardium; Nifedipine; Oxygen Consumption; Vasodilator Agents | 1985 |
Studies on the role of intracellular sodium and calcium in the centrally mediated pressor effects of CSF [Na+], ouabain and angiotensin II in anesthetized dogs.
Topics: Angiotensin II; Animals; Blood Pressure; Brain; Calcium; Dogs; Felodipine; Injections, Intraventricular; Intracellular Fluid; Models, Biological; Nifedipine; Ouabain; Saline Solution, Hypertonic; Sodium; Vagotomy | 1985 |
Lack of effect of anti-hypertensive treatment with felodipine on cardiovascular structure of young spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium; Cardiovascular System; Felodipine; Heart; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred Strains | 1985 |
Metal ions as allosteric regulators of calmodulin.
Topics: Calcium; Calmodulin; Felodipine; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Lanthanum; Metals; Nifedipine; Prenylamine; Spectrometry, Fluorescence; Strontium; Zinc | 1985 |
Bimodal column switching liquid chromatographic assay of six metabolites of [14C] felodipine in rat urine.
Topics: Animals; Biotransformation; Chromatography, Liquid; Felodipine; Male; Nifedipine; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1985 |
The influence of felodipine and diethyl-stilboestrol on [3H]noradrenaline release in the rat trachea.
Topics: Animals; Calcium; Culture Media; Diethylstilbestrol; Felodipine; Female; In Vitro Techniques; Male; Muscle, Smooth; Nifedipine; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Trachea | 1985 |
Cooperativity among calmodulin's drug binding sites.
Topics: Antihypertensive Agents; Benzazepines; Binding Sites; Calcium; Calmodulin; Diltiazem; Felodipine; Kinetics; Nifedipine; Prenylamine; Protein Binding; Spectrometry, Fluorescence | 1985 |
The actions of felodipine on arrhythmias and other responses to myocardial ischaemia in conscious rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Electrocardiography; Felodipine; Heart Rate; Male; Myocardial Infarction; Nifedipine; Rats; Rats, Inbred Strains | 1985 |
The effect of a new calcium antagonist, felodipine, on pulmonary hypertension and gas exchange in chronic obstructive lung disease.
Topics: Adult; Aged; Calcium Channel Blockers; Dose-Response Relationship, Drug; Felodipine; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Lung Diseases, Obstructive; Male; Middle Aged; Nifedipine; Pulmonary Gas Exchange | 1985 |
Felodipine, an arteriolar dilator with pronounced antihypertensive effect.
Topics: Antihypertensive Agents; Arterioles; Blood Pressure; Felodipine; Humans; Hypertension; Kidney; Male; Middle Aged; Nifedipine; Pyridines | 1983 |
Inhibition of turkey gizzard myosin light chain kinase activity by BAY K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calmodulin; Enzyme Activation; Felodipine; Gizzard, Avian; In Vitro Techniques; Myosin-Light-Chain Kinase; Nifedipine; Nitrendipine; Protein Kinase Inhibitors; Turkeys | 1984 |
Effects of verapamil, diltiazem, nisoldipine and felodipine on sarcoplasmic reticulum.
Topics: Animals; Calcium Channel Blockers; Calcium-Transporting ATPases; Centrifugation, Density Gradient; Diltiazem; Dogs; Felodipine; In Vitro Techniques; Microsomes; Muscles; Myocardium; Nifedipine; Nisoldipine; Potassium Chloride; Rabbits; Sarcoplasmic Reticulum; Species Specificity; Verapamil | 1984 |
Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Cardiovascular System; Circadian Rhythm; Felodipine; Heart Rate; Hypertension; Methyldopa; Metoprolol; Nifedipine; Rats; Rats, Inbred SHR; Time Factors | 1984 |
Antagonism of calmodulin and phosphodiesterase by nifedipine and related calcium entry blockers.
Topics: Calcium Channel Blockers; Calmodulin; Cyclic AMP; Enzyme Activation; Felodipine; In Vitro Techniques; Isomerism; Nifedipine; Phosphodiesterase Inhibitors; Structure-Activity Relationship | 1984 |
Intracellular sodium, membrane potential, and contractility of rat mesenteric small arteries.
Topics: Animals; Antihypertensive Agents; Calcium; Felodipine; In Vitro Techniques; Ion Channels; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Ouabain; Potassium; Rats; Rats, Inbred Strains; Sodium; Vascular Resistance | 1984 |
Effects of vasodilator treatment with felodipine on haemodynamic responses to treadmill exercise in congestive heart failure.
Topics: Adult; Aged; Antihypertensive Agents; Drug Evaluation; Felodipine; Female; Heart Failure; Heart Function Tests; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Physical Exertion; Time Factors; Vasodilation; Vasodilator Agents | 1984 |
Acute haemodynamic effects of felodipine during beta blockade in patients with coronary artery disease.
Topics: Adult; Antihypertensive Agents; Atenolol; Blood Pressure; Cardiac Catheterization; Cardiac Pacing, Artificial; Coronary Disease; Felodipine; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Stroke Volume; Vascular Resistance; Vasodilator Agents | 1984 |
Restoration of normal reflex responses to orthostatic stress during felodipine therapy in congestive heart failure.
Topics: Adult; Aged; Felodipine; Female; Heart; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Norepinephrine; Posture; Reflex, Abnormal | 1984 |
Effects of felodipine, nitrendipine and W-7 on arterial myosin phosphorylation, actin-myosin interactions and contraction.
Topics: Actins; Actomyosin; Animals; Calmodulin; Cattle; Contractile Proteins; Felodipine; In Vitro Techniques; Muscle, Smooth, Vascular; Myocardium; Myosins; Nifedipine; Nitrendipine; Phosphorylation; Protein Binding; Rabbits; Sulfonamides; Vasoconstriction | 1984 |
Urinary metabolites of felodipine, a new vasodilator drug, in man, dog, rat and mouse.
Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dogs; Esterification; Felodipine; Gas Chromatography-Mass Spectrometry; Humans; Male; Mice; Nifedipine; Oxidation-Reduction; Rats; Rats, Inbred Strains; Vasodilator Agents | 1984 |
Cytochrome P-450-dependent oxidation of felodipine--a 1,4-dihydropyridine--to the corresponding pyridine.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Felodipine; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Synthesis and preparative liquid chromatographic purification of reference compounds of three metabolites of the vasodilating drug felodipine.
Topics: Chromatography, Liquid; Felodipine; Humans; Mass Spectrometry; Nifedipine; Reference Standards | 1984 |
Physico-chemical properties of urinary metabolites of felodipine, a new vasodilator drug. II. Lactone kinetics, acid dissociation and distribution constants of two hydroxycarboxylic metabolites.
Topics: Acids; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry, Physical; Felodipine; Hydrolysis; Hydroxy Acids; Kinetics; Lactones; Nifedipine | 1984 |
Inhibition of turkey gizzard myosin light chain. Kinase activity by dihydropyridine calcium antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Felodipine; Gizzard, Avian; Kinetics; Myosin-Light-Chain Kinase; Myosins; Nifedipine; Nitrendipine; Phosphorylation; Protein Kinase Inhibitors; Trypsin; Turkeys | 1984 |
Hemodynamic effects of felodipine at rest and during exercise in exertional angina pectoris.
Topics: Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Dose-Response Relationship, Drug; Electrocardiography; Felodipine; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Physical Exertion; Pyridines; Vascular Resistance | 1983 |
Cardiovascular actions of the calmodulin inhibitor felodipine.
Topics: Animals; Antihypertensive Agents; Calmodulin; Coronary Circulation; Felodipine; Heart; Hemodynamics; Injections, Intravenous; Myocardium; Nifedipine; Oxygen Consumption; Swine | 1983 |
The systemic and coronary haemodynamic effects of felodipine in patients with coronary heart disease.
Topics: Adult; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Cardiac Catheterization; Coronary Circulation; Felodipine; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Vascular Resistance | 1983 |
Renal tubular site of action of felodipine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diuresis; Felodipine; Glomerular Filtration Rate; Kidney Tubules; Male; Natriuresis; Nifedipine; Rats; Rats, Inbred Strains; Urodynamics; Water-Electrolyte Balance | 1984 |
Acute haemodynamic and metabolic effects of felodipine in congestive heart failure.
Topics: Adult; Aged; Fatty Acids, Nonesterified; Felodipine; Glucose; Heart Failure; Hemodynamics; Humans; Lactates; Male; Middle Aged; Myocardium; Nifedipine; Oxygen Consumption | 1984 |
Short-term effects of felodipine, a new dihydropyridine, in hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Evaluation; Felodipine; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1984 |
Felodipine in primary pulmonary hypertension. Report of two cases.
Topics: Adult; Antihypertensive Agents; Felodipine; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Nifedipine; Vascular Resistance | 1984 |
Effects of felodipine on systemic and coronary haemodynamics in patients with angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Cardiac Pacing, Artificial; Coronary Circulation; Electrocardiography; Felodipine; Female; Hemodynamics; Humans; Lactates; Lactic Acid; Male; Middle Aged; Myocardium; Nifedipine | 1984 |
Haemodynamic effects of a new vasodilator drug, felodipine, in healthy subjects.
Topics: Adult; Echocardiography; Felodipine; Hemodynamics; Humans; Male; Nifedipine; Pyridines | 1983 |
Allosteric interactions among drug binding sites on calmodulin.
Topics: Allosteric Site; Calcium; Calcium-Binding Proteins; Calmodulin; Felodipine; Nifedipine; Protein Binding; Pyridines; Spectrometry, Fluorescence | 1983 |
A fluorescent calmodulin that reports the binding of hydrophobic inhibitory ligands.
Topics: Anilino Naphthalenesulfonates; Calcium; Calcium-Binding Proteins; Calmodulin; Felodipine; Fluorescent Dyes; Imidazoles; Ligands; Liposomes; Nifedipine; Protein Binding; Spectrometry, Fluorescence; Trifluoperazine | 1983 |
The effect of felodipine on ventricular fibrillation after coronary artery ligation in the anaesthetized pig.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Coronary Vessels; Felodipine; Heart Rate; Nifedipine; Propranolol; Pyridines; Swine; Ventricular Fibrillation | 1983 |
Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Binding Proteins; Calmodulin; Coronary Vessels; Felodipine; Myocardial Contraction; Nifedipine; Sulfonamides; Swine; Trifluoperazine; Vasodilator Agents | 1983 |
Interaction of the antihypertensive drug felodipine with calmodulin.
Topics: Animals; Antihypertensive Agents; Cadmium; Calcium; Calcium-Binding Proteins; Calmodulin; Felodipine; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Pyridines; Rats; Vasomotor System; Veins | 1981 |
Evidence that the increased calcium sensitivity of resistance vessels in spontaneously hypertensive rats is an intrinsic defect of their vascular smooth muscle.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium; Disease Models, Animal; Felodipine; Hypertension; Hypertension, Renal; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Vascular Resistance | 1981 |
Grapefruit juice interactions with drugs.
Topics: Beverages; Caffeine; Citrus; Cyclosporine; Estrogens; Felodipine; Food-Drug Interactions; Humans; Midazolam; Nifedipine; Terfenadine | 1995 |
Effects of felodipine, nifedipine and verapamil on cytosolic Ca2+ and contraction in vascular smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cytosol; Felodipine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits; Rats; Rats, Wistar; Verapamil | 1993 |
Vascular versus myocardial selectivity of dihydropyridine calcium antagonists as studied in vivo and in vitro.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Felodipine; Heart; Heart Rate; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Organ Specificity; Rats; Rats, Inbred SHR | 1995 |
Adverse Drug Reactions Advisory Committee. Gynaecomastia in association with calcium antagonists.
Topics: Adult; Aged; Calcium Channel Blockers; Diltiazem; Felodipine; Gynecomastia; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1994 |
Use of two in vitro glomerular models to study the renal vasoreactivity of cyclosporine.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Felodipine; Glomerular Mesangium; In Vitro Techniques; Kidney Cortex; Kidney Glomerulus; Kinetics; Nifedipine; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Verapamil | 1994 |
Drug-induced gingival overgrowth and class II major histocompatibility antigens.
Topics: Adult; Amlodipine; Azathioprine; Cyclosporine; Diabetes Mellitus, Type 1; Felodipine; Female; Gingiva; Gingival Diseases; Histocompatibility Testing; HLA-DR Antigens; Humans; Kidney Transplantation; Male; Nifedipine; Retrospective Studies; Risk Factors | 1994 |
Effects of dihydropyridine calcium-antagonists on intracellular action potentials of rabbit sinus node, atrium and atrioventricular node. Comparison of felodipine with nifedipine.
Topics: Action Potentials; Animals; Atrioventricular Node; Blood Pressure; Felodipine; Female; Heart Atria; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Neural Conduction; Nifedipine; Rabbits; Sinoatrial Node | 1994 |
Comparison of effects of dihydropyridine calcium antagonists on left ventricular systolic and diastolic performance.
Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Dogs; Felodipine; Heart; Heart Rate; Heart Ventricles; Hemodynamics; Myocardial Contraction; Nifedipine | 1994 |
Clinical outcome of a mandatory formulary switch for dihydropyridine calcium channel blocker therapy at a Veteran's Administration Medical Center.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Connecticut; Felodipine; Female; Formularies, Hospital as Topic; Heart Rate; Hospitals, Veterans; Humans; Hypertension; Male; Middle Aged; Nifedipine; Patient Satisfaction; Prospective Studies; Surveys and Questionnaires; Treatment Outcome | 1996 |
Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Felodipine; Fumarates; Heart; Iron; Lipid Peroxidation; Male; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female; In Vitro Techniques; Ketanserin; Male; Mianserin; Muscle Contraction; Nifedipine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reproducibility of Results; Ritanserin; Serotonin Antagonists; Verapamil | 1997 |
[Stable angina pectoris: what is the role of calcium antagonists?].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Felodipine; Humans; Metoprolol; Multicenter Studies as Topic; Nifedipine; Randomized Controlled Trials as Topic; Verapamil | 1997 |
Regulation of red blood cell filterability by Ca2+ influx and cAMP-mediated signaling pathways.
Topics: Adult; Alprostadil; Calcium; Calcium Channel Blockers; Cyclic AMP; Dinoprostone; Epinephrine; Erythrocyte Deformability; Erythrocytes; Felodipine; Filtration; Humans; In Vitro Techniques; Kinetics; Male; Nifedipine; Pentoxifylline; Signal Transduction; Stress, Mechanical | 1997 |
Replacing short-acting nifedipine with alternative medications at a large health maintenance organization.
Topics: Aged; Calcium Channel Blockers; Cohort Studies; Delayed-Action Preparations; Drug Utilization; Felodipine; Female; Follow-Up Studies; Health Maintenance Organizations; Humans; Hypertension; Male; Nifedipine; Retreatment; Safety | 1998 |
Rational use of calcium-channel antagonists in Raynaud's phenomenon.
Topics: Amlodipine; Calcium Channel Blockers; Diltiazem; Felodipine; Humans; Isradipine; Nicardipine; Nifedipine; Raynaud Disease | 1998 |
Electrophysiological effects of felodipine on guinea pig papillary muscles.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Electrophysiology; Felodipine; Female; Guinea Pigs; Male; Nifedipine; Papillary Muscles; Patch-Clamp Techniques; Verapamil | 1996 |
Influence of calcium antagonist drugs in myasthenia gravis in the elderly.
Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Felodipine; Female; Humans; Male; Myasthenia Gravis; Neuromuscular Junction; Nifedipine | 1998 |
Micronization of drugs using supercritical carbon dioxide.
Topics: Biological Availability; Calcium Channel Blockers; Carbon Dioxide; Chemistry, Pharmaceutical; Felodipine; Fenofibrate; Hypolipidemic Agents; Nifedipine; Particle Size; Solubility; Solutions | 1999 |
Investigation of prandial effects on hydrophilic matrix tablets.
Topics: Chemistry, Pharmaceutical; Eating; Excipients; Felodipine; Food-Drug Interactions; Hydrogen-Ion Concentration; In Vitro Techniques; Nifedipine; Solubility; Surface-Active Agents; Tablets; Water | 1999 |
Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin.
Topics: Animals; Bile Acids and Salts; Calcium Channels; Cholera Toxin; Felodipine; Granisetron; Intestinal Mucosa; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Serotonin | 1999 |
Free radicals in irradiated drugs: an EPR study.
Topics: Calcium Channel Blockers; Dose-Response Relationship, Radiation; Electron Spin Resonance Spectroscopy; Felodipine; Free Radicals; Gamma Rays; Nifedipine; Nimodipine; Nitrendipine | 1999 |
Incidence of gingival hyperplasia caused by calcium antagonists in continuous ambulatory peritoneal dialysis patients.
Topics: Adult; Amlodipine; Calcium Channel Blockers; Cardiovascular Diseases; Felodipine; Female; Gingival Hyperplasia; Humans; Male; Middle Aged; Nifedipine; Peritoneal Dialysis, Continuous Ambulatory | 1999 |
Retrospective evaluation of the conversion of amlodipine to alternative calcium channel blockers.
Topics: Amlodipine; Blood Pressure; Calcium Channel Blockers; Diltiazem; Felodipine; Female; Humans; Hypertension; Male; Nifedipine; Retrospective Studies | 2000 |
Stroke precipitated by moderate blood pressure reduction.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Emergency Treatment; Felodipine; Female; Humans; Hypertension; Labetalol; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Nifedipine; Patient Selection; Precipitating Factors; Stroke; Tomography, X-Ray Computed | 2000 |
Normal-phase TLC separation of enantiomers of 1.4-dihydropyridine derivatives.
Topics: Calcium Channel Blockers; Chromatography, Thin Layer; Dihydropyridines; Felodipine; Methanol; Nifedipine; Solvents; Stereoisomerism | 2001 |
Efficacy and safety of a therapeutic interchange from high-dose calcium channel blockers to a fixed-dose combination of amlodipine/benazepril in patients with moderate-to-severe hypertension.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Benzazepines; Blood Pressure; Calcium Channel Blockers; Costs and Cost Analysis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Felodipine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Treatment Outcome | 2001 |
Deleterious effects of nifedipine on smooth muscle cells implies alterations of intracellular calcium signaling.
Topics: Amlodipine; Aorta; Caffeine; Calcium; Calcium Channel Blockers; Calcium Signaling; Calcium-Transporting ATPases; Cells, Cultured; Endoplasmic Reticulum; Enzyme Inhibitors; Felodipine; Genistein; Humans; Muscle, Smooth, Vascular; Nifedipine; Protein-Tyrosine Kinases; Thapsigargin | 2001 |
Dihydropyridines are not substitutable without careful monitoring.
Topics: Adverse Drug Reaction Reporting Systems; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Felodipine; Humans; Nifedipine | 2002 |
Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine.
Topics: Binding Sites; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Felodipine; Humans; Kinetics; Midazolam; Models, Biological; Nifedipine; Substrate Specificity; Testosterone; Tumor Cells, Cultured | 2003 |
Oxidation of Hantzsch 1,4-dihydropyridines of pharmacological significance by electrogenerated superoxide.
Topics: Calcium Channel Blockers; Felodipine; Nifedipine; Nimodipine; Nitrendipine; Superoxides | 2004 |
Calcium channel antagonists and inhibition of human sphincter of Oddi contractions.
Topics: Calcium Channel Blockers; Felodipine; Humans; Muscle Contraction; Muscle, Smooth; Nifedipine; Sphincter of Oddi; Stimulation, Chemical; Tissue Culture Techniques; Verapamil | 2005 |
Novel design of osmotic chitosan capsules characterized by asymmetric membrane structure for in situ formation of delivery orifice.
Topics: Capsules; Chitosan; Cross-Linking Reagents; Delayed-Action Preparations; Diphosphates; Drug Carriers; Drug Compounding; Felodipine; Hydrogen-Ion Concentration; Hypromellose Derivatives; Linear Models; Membranes, Artificial; Methylcellulose; Nifedipine; Osmosis; Permeability; Pharmaceutical Preparations; Polyphosphates; Sodium Dodecyl Sulfate; Solubility; Surface Properties; Surface-Active Agents; Time Factors; Viscosity; Water | 2006 |
Simultaneous determination of nitrendipine and one of its metabolites in plasma samples by gas chromatography with electron-capture detection.
Topics: Calibration; Chromatography, Gas; Drug Stability; Felodipine; Freezing; Humans; Molecular Structure; Nifedipine; Pyridines; Reference Standards; Sensitivity and Specificity; Time Factors | 2007 |
A comparison of the physical stability of amorphous felodipine and nifedipine systems.
Topics: Calcium Channel Blockers; Chemical Phenomena; Chemistry, Physical; Drug Stability; Entropy; Felodipine; Hydrogen Bonding; Kinetics; Membranes, Artificial; Nifedipine; Pharmaceutic Aids; Povidone; Spectrophotometry, Infrared; Temperature; Thermodynamics | 2006 |
Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility.
Topics: Algorithms; Calcium Channel Blockers; Chemical Phenomena; Chemistry, Physical; Entropy; Felodipine; Forecasting; Models, Chemical; Nifedipine; Pharmaceutic Aids; Pharmaceutical Preparations; Polymers; Povidone; Solubility; Thermodynamics | 2006 |
The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.
Topics: Calcium Channel Blockers; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Gamma Rays; Humans; Hypertension; Models, Molecular; Molecular Conformation; Myocardial Ischemia; Nifedipine; Nimodipine | 2007 |
Recrystallization of nifedipine and felodipine from amorphous molecular level solid dispersions containing poly(vinylpyrrolidone) and sorbed water.
Topics: Crystallization; Drug Stability; Drug Storage; Felodipine; Humidity; Kinetics; Models, Chemical; Nifedipine; Povidone; Solubility; Solvents; Thermodynamics; Transition Temperature; Water; Wettability | 2008 |
Calorimetric study and modeling of molecular mobility in amorphous organic pharmaceutical compounds using a modified Adam-Gibbs approach.
Topics: Algorithms; Benzyl Alcohols; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Felodipine; Glucosides; Models, Molecular; Nifedipine; Nonlinear Dynamics; Pharmaceutical Preparations; Thermodynamics | 2007 |
Evaluation of drug-polymer miscibility in amorphous solid dispersion systems.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Felodipine; Ketoconazole; Models, Biological; Nifedipine; Polymers; Powders; Pyrrolidinones; Solubility; Thermodynamics; Water; X-Ray Diffraction | 2009 |
Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation.
Topics: Algorithms; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Microsomes, Liver; Midazolam; Molecular Structure; Nifedipine; Quinidine; Substrate Specificity; Testosterone | 2010 |
Highly efficient miniaturized coprecipitation screening (MiCoS) for amorphous solid dispersion formulation development.
Topics: Acrylic Resins; Chemical Precipitation; Chemistry, Pharmaceutical; Felodipine; Glyburide; Methylcellulose; Miniaturization; Nifedipine; Polymethacrylic Acids; Powders; Solubility | 2013 |
L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.
Topics: Animals; Aquaporins; beta-Crystallin B Chain; Calcium Channel Blockers; Calcium Channels, L-Type; Connexins; Eye Proteins; Felodipine; Female; Gene Expression; Immunoblotting; Lens, Crystalline; Male; Mice; Mice, Inbred C57BL; Myosin Light Chains; Nifedipine; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction | 2013 |
Enhancements and limits in drug membrane transport using supersaturated solutions of poorly water soluble drugs.
Topics: Biological Transport; Chemistry, Pharmaceutical; Crystallization; Diffusion; Drug Delivery Systems; Felodipine; Membranes; Nifedipine; Pharmaceutical Preparations; Pharmaceutical Solutions; Solubility; Thermodynamics; Water | 2014 |
A useful model capable of predicting the clearance of cytochrome 3A4 (CYP3A4) substrates in humans: validity of CYP3A4 transgenic mice lacking their own Cyp3a enzymes.
Topics: Alprazolam; Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Felodipine; Humans; Male; Mice; Mice, Transgenic; Microsomes, Liver; Midazolam; Nifedipine; Nitrendipine; Quinidine | 2014 |
Impact of Solubilizing Additives on Supersaturation and Membrane Transport of Drugs.
Topics: Biological Transport; Chemistry, Pharmaceutical; Diffusion; Felodipine; Intestinal Absorption; Kinetics; Nifedipine; Pharmaceutical Solutions; Solubility | 2015 |
Predictive Calculation of the Crystallization Tendency of Model Pharmaceuticals in the Supercooled State from Molecular Dynamics Simulations.
Topics: Crystallization; Diffusion; Felodipine; Molecular Conformation; Molecular Dynamics Simulation; Nifedipine; Phase Transition; Transition Temperature | 2015 |
Influence of 3 calcium channel blockers on gingival overgrowth in a population of severe refractory hypertensive patients.
Topics: Adult; Aged; Amlodipine; Brazil; Calcium Channel Blockers; Felodipine; Female; Gingival Overgrowth; Humans; Hypertension; Male; Middle Aged; Nifedipine; Periodontal Index | 2018 |
Polyvinylpyrrolidone affects thermal stability of drugs in solid dispersions.
Topics: Drug Stability; Felodipine; Indomethacin; Nifedipine; Povidone; Thermogravimetry | 2018 |
Amorphous Solid Dispersions of Felodipine and Nifedipine with Soluplus®: Drug-Polymer Miscibility and Intermolecular Interactions.
Topics: Calorimetry, Differential Scanning; Felodipine; Nifedipine; Pharmaceutical Preparations; Polyethylene Glycols; Polymers; Polyvinyls; Solubility | 2021 |
Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment.
Topics: Animals; Cytochrome P-450 CYP3A; Drug Combinations; Drugs, Chinese Herbal; Felodipine; Headache; Humans; Nifedipine; Rats; Retrospective Studies | 2022 |