nifedipine has been researched along with dihydropyridines in 475 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 108 (22.74) | 18.7374 |
| 1990's | 223 (46.95) | 18.2507 |
| 2000's | 92 (19.37) | 29.6817 |
| 2010's | 48 (10.11) | 24.3611 |
| 2020's | 4 (0.84) | 2.80 |
| Authors | Studies |
|---|---|
| Haruno, A; Kanda, A; Miyake, H; Nagasaka, M | 1 |
| Auchampach, JA; Gross, GJ; Maruyama, M; Pieper, GM; Warltier, DC | 1 |
| Akhadov, ShV; Belousov, IuB; Borisova, EO; Volkov, MG | 1 |
| Caricati-Neto, A; Castillo, CJ; García, AG; Jurkiewicz, A; Jurkiewicz, NH; Lafayette, S; Sette, M | 1 |
| Mikkelsen, EO; Nyborg, NB; Poulsen, SH | 1 |
| Inagaki, O; Kato, Y; Kimura, R; Matsuoka, Y; Yamada, S | 1 |
| Atkinson, J; Bray-des Boscs, L; Capdeville-Atkinson, C; Chillon, JM; Hoffman, M; Lartaud, I; Makki, T; Nicolas, JP | 1 |
| Gałewski, S; Kossut, M; Pomorski, P; Skangiel-Kramska, J | 1 |
| Glebova, RN; Grigorian, GL; Kalinina, MV; Timofeev, AA | 1 |
| Bilodeau, L; Durroux, T; Gallo-Payet, N; Payet, MD | 1 |
| Howlett, SE; Nicholl, PA | 1 |
| Abe, Y; Aki, Y; He, H; Iwao, H; Kiyomoto, H; Miyatake, A; Tamaki, T | 1 |
| Cosentino, M; Crema, A; D'Angelo, L; De Ponti, F; Einaudi, A; Frigo, GM | 1 |
| Goldmann, S; Stoltefuss, J; Triggle, DJ; Zheng, W | 1 |
| Asano, M; Shibasaki, K; Uchida, W | 1 |
| Burger, KJ; Distler, GA; Gross, P; Koppenhagen, K; Welzel, D; Wudel, E | 2 |
| Catt, KJ; Iida, T; Krsmanovic, LZ; Mellon, PL; Merelli, F; Stojilković, SS; Zheng, L | 1 |
| Brisac, AM; Dubray, C; Huguet, F; Roche, A | 1 |
| Colombo, G; Fadda, F; Garau, B; Gessa, GL | 1 |
| Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Budriesi, R; Chiarini, A; Fruttero, R; Gasco, A; Gasco, AM; Sorba, G | 1 |
| Benterbusch, R; Herberg, FW; Melzer, W; Thieleczek, R | 1 |
| Fitoussi, G; Nègre-Salvayre, A; Salvayre, R; Troly, M | 1 |
| Hata, H; Hojo, M; Katayama, O; Shibata, S; Tatsumi, H; Teramoto, N | 1 |
| Heynen, G | 1 |
| Mason, RP; Moisey, DM; Shajenko, L | 1 |
| Chibana, T; Noguchi, K; Ojiri, Y; Sakanashi, M | 1 |
| Edgar, B; Eriksson, UG; Lundahl, J; Miniscalco, A; Regårdh, CG | 1 |
| Belz, GG; Bliesath, H; Essig, J; Neumann, N; Wurst, W; Zech, K | 1 |
| Findlay, JD; Pullar, IA | 1 |
| Gergeĺ, D; Misík, V; Ondrias, K; Stasko, A | 1 |
| Arena, JP; Chin, S; Kass, RS | 2 |
| McCarty, NA; O'Neil, RG | 1 |
| Herbette, LG; Mason, RP; Moring, J | 1 |
| Cuccaro, ML; Jacobs, LS; Lorenson, MY | 1 |
| Gainullin, R; Saxon, M | 1 |
| Bolger, GT; O'Neill, SK | 2 |
| Bolger, GT; Campbell, N; Crowley, M; McKay, DW; O'Neill, SK; Triggle, CR | 1 |
| Furukawa, T; Katsuragi, T; Ogawa, S; Shirakabe, K; Soejima, O | 1 |
| Jacobs, LS; Jones, SW | 1 |
| Bacskai, BJ; Friedman, PA | 1 |
| Bartrup, JT; Stone, TW | 2 |
| Kocsis, JD; O'Regan, MH; Waxman, SG | 1 |
| Peers, C | 1 |
| Astier, H; Roussel, JP | 1 |
| Dubyak, GR; Jones, SW; Marks, TN | 1 |
| Brocklehurst, KW; Ceña, V; Pollard, HB; Rojas, E | 1 |
| Chaĭka, AD; Kolchinskaia, LI; Kravets, LA; Sokolov, IuV | 1 |
| Suszkiw, JB; Tomsig, JL | 1 |
| Botelho, MA; Correia, JM; Mariano-Pego, G; Rocha-Gonçalves, F; Viegas, J | 1 |
| Gambini, F; Gaviraghi, G; Micheli, D; Quartaroli, M; Tarter, G; Trist, DG | 1 |
| Aihara, H; Kaneko, K; Tsuchida, K | 1 |
| Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A | 1 |
| Leonetti, G | 1 |
| Arosio, E; Lechi, A; Montesi, G; Montresor, G; Sheiban, I; Tonni, S | 1 |
| Gandhi, V; Hester, RK; Hojo, M; Jino, H; Jones, DJ; Kodama, I; Satake, N; Shibata, S; Tatsumi, H; Wang, CG | 1 |
| Aoki, K; Kishimoto, T; Naruchi, T; Okamiya, Y; Takeshita, T; Tanabe, H | 1 |
| Dong, H; Lu, YQ; Wang, Q; Yang, QQ; Yang, ZC | 1 |
| Dohmoto, H; Goto, A; Yamada, K; Yoshimoto, R | 1 |
| Akimoto, Y; Fujiwara, M; Kurahashi, K; Usui, H | 1 |
| Bäärnhielm, C; Berntsson, P; Brian, WR; Guengerich, FP; Iwasaki, M; Sari, MA | 1 |
| Brown, NL; Pruneau, D; Roy, F | 1 |
| Bockaert, J; Pin, JP | 1 |
| Fitzpatrick, LA; Jones, JI | 1 |
| Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J | 1 |
| Gotoh, Y; Imaizumi, Y; Watanabe, M; Yamamoto, M | 1 |
| Benishin, CG; Karpinski, E; Pang, PK; Shan, J; Wang, R; Wu, LY | 1 |
| Dale, N; Edmonds, B; Kandel, ER; Klein, M | 1 |
| Langs, DA; Strong, PD; Triggle, DJ | 1 |
| Inoue, Y; Kitamura, K; Kuriyama, H; Nakao, K; Oike, M | 1 |
| Abe, K; Kanazawa, M; Kohzuki, M; Kudo, K; Omata, K; Sato, M; Takeuchi, K; Tsunoda, K; Yasujima, M; Yoshida, K | 2 |
| Atwater, I; Boschero, AC; Carroll, PB; De Souza, C | 1 |
| Born, L; Goldmann, S; Kazda, S; Pittel, B; Schramm, M | 1 |
| Carlucci, G; Colanzi, A; Mazzeo, P | 1 |
| Hosey, MM; McMahon, KK; Ptasienski, J | 1 |
| Carpenter, CL; Cooper, EC; Greenberg, DA | 2 |
| Lee, HR; Roeske, WR; Watson, M; Yamamura, HI | 1 |
| Brown, AM; Dumont, L; Grupp, G; Grupp, IL; Hamilton, S; Schwartz, A; Vaghy, PL; Williams, JS; Yatani, A | 1 |
| Schramm, M; Towart, R | 1 |
| Litzinger, MJ; Nelson, PG; Pun, RY | 1 |
| Rubanyi, GM; Schwartz, A; Vanhoutte, PM | 1 |
| Creba, JA; Karobath, M | 1 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Callewaert, G; Droogmans, G | 1 |
| Kongsamut, S; Miller, RJ | 1 |
| Bean, BP; Hermsmeyer, K; Puga, A; Sturek, M | 1 |
| Ehrhard, P; Fischli, W; Holck, M; Kozlowski, R; Osterrieder, W | 1 |
| Bean, BP; Hess, P; Lansman, JB; Nilius, B; Nowycky, MC; Tsien, RW | 1 |
| Gurney, AM; Nerbonne, JM | 1 |
| Holck, M; Osterrieder, W | 1 |
| Ferry, DR; Glossmann, H; Goll, A | 1 |
| Hardman, HF; Preuss, KC; Shimshak, TM; Warltier, DC; Wynsen, JC | 1 |
| Berg, C; DiFrancesco, GF; Gittos, M; Mir, AK; Petty, MA; Spedding, M | 1 |
| Dunlap, K; Holz, GG; Rane, SG | 1 |
| Di Francesco, GF; Petty, MA; Spedding, M | 1 |
| Abram, A; Baginski, T; Banning, J; Rao, V | 1 |
| Dunlap, K; Holz, GG; Kream, RM | 1 |
| Basile, AS; Bolger, GT; Lesieur, P; Skolnick, P | 1 |
| Furukawa, T; Katsuragi, T; Usune, S | 1 |
| Lamb, GD; Walsh, T | 1 |
| Cadet, JL; Freed, WJ; Taylor, E | 1 |
| Humphries, RG; O'Connor, SE | 1 |
| Fleming, JS; Hanson, RC; Poindexter, GS; Rosenberger, LB; Stanton, HC | 1 |
| Chaumet-Riffaud, P; Lemaire, M; Pinquier, JL; Tillement, JP; Urien, S | 1 |
| Massieu, L; Tapia, R | 1 |
| Brisac, AM; Lacolley, P; Laurent, S; Legrand, M; Schmitt, H; Tsoucaris-Kupfer, D | 1 |
| Botana, L; Eleno, N; Espinosa, J | 1 |
| Catt, KJ; Hausdorff, WP | 1 |
| Burnstock, G; MacKenzie, I; Manzini, S | 1 |
| Bogónez, E; Martínez-Serrano, A; Satrústegui, J; Vitórica, J | 1 |
| Cortese, C; Ferrara, LA; Gnasso, A; Mancini, M; Marotta, T; Pasanisi, F | 1 |
| Anderson, EG; Scroggs, RS | 1 |
| Chiu, M; Dionne, MA; Marsh, JD; Smith, TW | 1 |
| Olsen, R; Powis, G; Seewald, M | 1 |
| Al-Dahan, MI; Thalmann, RH | 1 |
| Aaronson, PI; Bolton, TB; Lang, RJ; MacKenzie, I | 1 |
| Briand, V; Laurent, S; Schmitt, H | 1 |
| Jones, SW; Marks, TN | 1 |
| Gotoh, Y; Imaizumi, Y; Kawai, T; Kumadani, S; Watanabe, M | 1 |
| Alker, D; Beresford, AP; Kobylecki, RJ; Macrae, PV | 1 |
| Fleckenstein, A; Fleckenstein-Grün, G; Frey, M; Zorn, J | 1 |
| Matlib, MA | 1 |
| Chartrand, C; Dumont, L; Kangha, M; Lord, C | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Hajimohamadreza, I | 1 |
| Aizawa, T; Komatsu, M; Nagasawa, Y; Takeda, T; Yamada, T; Yokokawa, N | 1 |
| Kishino, J; Takemura, M; Wada, H; Yamatodani, A | 1 |
| Dolphin, AC; Scott, RH | 1 |
| Stjärne, E; Stjärne, L | 1 |
| Challenor, VF; George, CF; Waller, DG | 1 |
| Goldin, SM; Turner, TJ | 1 |
| Freedman, SB; Kongsamut, S; Miller, RJ | 1 |
| Nakajima, S; Ninomiya, M; Tani, T; Ueda, M | 1 |
| Nagaoka, A; Shibota, M | 1 |
| Dubur, GIa; Ivakhniuk, IS; Shvinka, NE; Skrastyn'sh, IP; Velena, AKh | 1 |
| Bacon, KB; Camp, RD; Westwick, J | 1 |
| Arcaro, G; Arosio, E; Lechi, A; Montesi, G; Paluani, F; Pancera, P; Priante, F | 1 |
| Tamargo, J; Tejerina, T | 1 |
| Akula, M; Knaus, EE; Matowe, WC; Wolowyk, MW | 1 |
| Andersen, N; Gougoutas, J; Hedberg, A; Kimball, SD; Malley, M; Moreland, S; Porubcan, M; Pudzianowski, A; Rovnyak, G | 1 |
| Soldatov, NM | 1 |
| Bisenieks, EA; Caffier, G; Shvinka, NE; Velena, AKh; Vinogradova, TA | 1 |
| Knaus, EE; Li-Kwong-Ken, MC; Soboleski, DA; Triggle, CR; Wolowyk, MW; Wynn, H | 1 |
| Alfaro, MJ; Martin, I; Tamargo, J | 1 |
| Inaba, M; Shinoda, H; Tsuruo, T | 1 |
| Bolger, GT; Rafferty, MF; Skolnick, P | 1 |
| Arrowsmith, JE; Blackburn, KJ; Burges, RA; Campbell, SF; Cross, PE; Gardiner, DG; Stubbs, JK | 1 |
| Chhabra, A; Fairhurst, AS; Thayer, SA; Welcome, M | 1 |
| Ahmad, S; Daniel, EE; Grover, AK; Kwan, CY; Oakes, P; Ramlal, T; Triggle, DJ | 1 |
| Dubur, GJ; Gendvilienè, VI; Kimenis, AA; Macianskiene, RA; Narusevicius, EV; Selga, MJ; Simkhovich, BZ; Velena, AH; Vitolina, RO; Zarinsh, GV | 1 |
| Barrett, JE; Bolger, GT; Lueddens, H; Paul, SM; Skolnick, P; Weissman, BA; Witkin, J | 1 |
| Campbell, KP; Kahl, SD; Sharp, A; Strom, M | 1 |
| Bäärnhielm, C; Hansson, G | 1 |
| Bowling, N; Conery, BG; Hayes, JS; Kauffman, RF | 1 |
| Brandt, NR; Caswell, AH; Kawamoto, RM | 1 |
| Galiano, A; Nyska, A; Nyska, M; Pirak, M; Sela, M; Waner, T | 1 |
| Duncker, DJ; Saxena, PR; Verdouw, PD | 1 |
| Alfaro, MJ; Martin, M; Tamargo, J | 1 |
| Luca, C; Marchini, F; Pacei, E | 1 |
| Katz, AM; Leach, NM | 1 |
| Nishikibe, M | 1 |
| Ortega, MP; Priego, JG; Statkow, PR; Sunkel, C | 1 |
| Delgado, C; Tamargo, J; Tejerina, T; Valenzuela, C | 1 |
| Luca, C; Marchini, F; Pacei, E; Valli, L | 1 |
| Harada, N; Miyano, T; Murayama, B; Nagura, J; Suzuki, K; Takeya, K; Yajima, M | 1 |
| Bolger, GT; Crawley, JN; Paul, SM; Rafferty, MF; Skolnick, P | 1 |
| Kase, N; Kita, H; Uematsu, T; Yamaura, T | 1 |
| Haegele, KD; Huebert, ND; Spedding, M | 1 |
| Giacomini, JC; Giacomini, KM; Nelson, WL; Zobrist, RH | 1 |
| Enomoto, H; Fukui, H; Kimura, K; Kimura, Y; Miura, A; Morino, A; Okamoto, M; Tanaka, M | 1 |
| Fukutani, T; Ikawa, H; Kase, N; Mizutani, H; Watanabe, D; Yamaura, T | 1 |
| Cavero, I; Spedding, M | 1 |
| Kass, RS; Sanguinetti, MC | 1 |
| Jones, H; Khandwala, A; Van Inwegen, RG; Weinryb, I | 1 |
| Bolger, G; Fraser, CM; Jung, CY; Schaber, JS; Triggle, DJ; Venter, JC | 1 |
| Heaslip, RJ; Rahwan, RG | 1 |
| Freedman, SB; Miller, RJ | 1 |
| Altura, BM; Altura, BT | 1 |
| Luu, MD; Martin, JV; Mendelson, WB; Paul, SM; Skolnic, P; Wagner, R | 1 |
| Fossheim, R; Mostad, A; Rømming, C; Shefter, E; Svarteng, K; Triggle, DJ | 1 |
| Pfaffendorf, M; Pijl, AJ; van Zwieten, PA | 1 |
| de Boland, AR; Vazquez, G | 1 |
| Bagó, A; Deák, F; Hunyady, L; Rohács, T; Spät, A | 1 |
| Dockrell, ME; Haynes, WG; Olverman, HJ; Waugh, CJ; Webb, DJ; Williams, BC | 1 |
| Mizusawa, H; Omote, M | 1 |
| Hettrick, DA; Pagel, PS; Warltier, DC | 1 |
| Ito, S; Kitamura, N; Nakazato, Y; Ohta, T | 1 |
| Browaeys-Poly, E; Guilbault, P; Ouadid, H; Vilain, JP | 1 |
| Friedman, PA; Gesek, FA | 2 |
| Croxton, TL; Farley, LS; Hirshman, CA; Vannier, C | 1 |
| Berger, AJ; Umemiya, M | 1 |
| Guérineau, NC; Israel, JM; Lledo, PM; Verrier, D | 1 |
| Hamaguchi, M; Imai, S; Ishibashi, T; Kato, K; Kawada, T; Mitomi, A | 1 |
| Gu, R; Jiang, S; Su, Z | 1 |
| Calabresi, P; De Murtas, M; Marciani, MG; Mercuri, NB; Pisani, A; Stefani, A | 1 |
| Fukata, F; Kanda, M; Kurahashi, K; Matsui, H; Nakamura, S; Shirahase, H; Wada, K | 1 |
| Astier, H; Grazzini, E; Guipponi, M; Roussel, JP | 1 |
| Carbone, E; Magnelli, V; Pollo, A; Sher, E | 1 |
| Circo, A; D'Onofrio, V; Gulizia, M; Platania, F; Rizzini, P; Valenti, R | 1 |
| Leonetti, G; Salvi, S | 1 |
| Biasco, MG; Ciccone, M; Corriero, F; Di Michele, L; Di Noia, D; Rizzon, P | 1 |
| Marchisio, M; Pascale, C; Santoro, A; Zampaglione, B | 1 |
| Flammer, J; Lang, MG; Lüscher, TF; Meyer, P | 1 |
| Furberg, CD; Meyer, JV; Psaty, BM | 1 |
| Hattori, K; Maruyama, K; Nagatomo, T; Qu, YL; Sugiyama, K; Takamizawa, C; Watanabe, K | 1 |
| Kimura, T; Satoh, S; Takeuchi, A | 1 |
| Mathy, MJ; Pfaffendorf, M; van Zwieten, PA | 2 |
| Horowitz, B; Hume, JR; Kenyon, JL; Overturf, K; Rich, A; Sanders, KM | 1 |
| Foster, RW; Green, KA; Small, RC | 1 |
| Momiyama, A; Yawo, H | 1 |
| Satoh, H; Tsuchida, K | 1 |
| Asano, M; Shibasaki, K; Takenaka, T; Uchida, W | 1 |
| Arimura, T; Kobayashi, K; Okada, T; Piccolino, M; Tachibana, M | 1 |
| Takeda, Y | 1 |
| Asano, M; Matsuda, Y; Shibasaki, K; Takenaka, T; Uchida, W | 1 |
| Zanchetti, A | 1 |
| Abrahamsson, T; Akerblom, B; Nordlander, M; Thalén, P | 1 |
| Courseau, C; Garay, R; Giraud, F; Hannaert, P; Pallotta, M; Rota, R | 1 |
| Elliott, HL | 1 |
| Franceschini, G; Sirtori, CR | 1 |
| Baldelli, P; Birnbaumer, L; Neely, A; Olcese, R; Stefani, E; Wei, X | 1 |
| Bockaert, J; Chavis, P; Fagni, L; Shinozaki, H | 1 |
| Rao, MR; Xi, T | 1 |
| Miyajima, E; Miyata, N; Otomo, S; Tsuchida, K; Yamaura, H | 1 |
| Dohi, Y; Kojima, M; Sato, K | 1 |
| Chen, HC; Guh, JY; Hwang, SJ; Lai, YH; Tsai, JC; Tsai, JH | 1 |
| Abrosimov, IIu; Karpova, MN; Kryzhanovskiĭ, GN; Lakinina, MV; Pankov, OIu | 1 |
| Chaylakhyan, LM; Grishchenko, VM; Zherelova, OM | 1 |
| Ichihara, K; Mori, H; Nagasaka, M; Okumura, K | 1 |
| Ullal, GR | 1 |
| Dubray, C; Francheteau, P; Guerret, M; Merdjan, H; Steimer, JL | 1 |
| Dryer, SE; Wisgirda, ME | 1 |
| Arnold, JM; Bailey, DG; Spence, JD | 1 |
| Morales, JM; Rodicio, JL; Ruilope, LM | 1 |
| Pfaffendorf, M; van Zwieten, PA | 2 |
| Hojo, M; Katayama, O; Tanaka, Y; Teramoto, N | 1 |
| Aoki, K; Hoshina, K; Kishimoto, T; Okamiya, Y; Sunakawa, K; Takeshita, T | 1 |
| Liu, DQ; Sheng, BH; Zhao, DH; Zhou, SS | 1 |
| Karasawa, A; Kubo, K; Shirakura, S | 1 |
| Aoki, K; Hoshina, K; Kishimoto, T; Okamiya, Y; Ota, M; Takeshita, T | 1 |
| Crosbie, GV; Grice, JE; Hockings, GI; Jackson, RV; Walters, MM | 1 |
| Appel, SH; Delbono, O; Magnelli, V; Sawada, T; Smith, RG; Stefani, E | 1 |
| Carganico, G; Cozzi, P; Fusar, D; Grossoni, M; Menichincheri, M; Pinciroli, V; Salvati, P; Tonani, R; Vaghi, F | 1 |
| Imai, S; Kawada, T; Nakazawa, M; Sun, HT | 1 |
| Aoudjit, F; Dupuis, G; Payet, MD; Ricard, I | 1 |
| Bachetti, T; Carboni, L; Ferri, S; Ratti, E; Spampinato, S; Van Amsterdam, FT | 1 |
| Andersson, E; Fried, G; Liu, YA | 1 |
| Bagchi, D; Das, DK; Engelman, RM; Liu, X; Nath, D; Rousou, JA; Wei, Z | 1 |
| Hayashi, Y; Hiruma, T; Hosono, M; Kato, H; Ohnishi, H; Takata, Y; Watanabe, K | 1 |
| Avaltroni, A; Carbone, E; Magnelli, V | 1 |
| Beevers, DG; Sleight, P | 1 |
| Dhein, S; Klaus, W; Salameh, A; Simsek, S; Zhao, Y | 1 |
| Kugiyama, K; Ogawa, H; Okumura, K; Tsuchiya, T; Yasue, H | 1 |
| Kanda, A; Miyake, H; Miyoshi, K; Nakano, M; Nozawa, Y | 1 |
| Gizinski, MJ; Schumaker, KS | 1 |
| Balla, T; Catt, KJ; Rössig, L; Zólyomi, A | 1 |
| Dozen, M; Hayashi, Y; Hosono, M; Watanabe, K | 1 |
| Masumiya, H; Saito, W; Sekine, T; Shigenobu, K; Sijuku, T; Sugahara, M; Tanaka, H; Taniguchi, H; Terada, M | 1 |
| Akopov, SE | 1 |
| Kimura, R; Miyake, H; Nozawa, Y; Ohkura, T; Uchida, S; Yamada, S | 1 |
| Brown, DA; Filippov, AK | 1 |
| Ananthanarayanan, VS; Zhorov, BS | 1 |
| Fukao, M; Hattori, Y; Houzen, H; Kanno, M; Qi, F; Yamada, Y | 1 |
| Katina, IE; Lukyanenko, V; Nasledov, GA; Terentyev, DA | 1 |
| Hong, J; Hopf, FW; Reddy, P; Steinhardt, RA | 1 |
| Fujikura, N; Masuda, Y; Shikada, K; Tanaka, S; Yokoyama, T | 2 |
| Leenen, FH | 1 |
| Dei Cas, L; Fappani, A; Metra, M; Nodari, S; Pelá, G; Raddino, R | 1 |
| Kikuchi, K; Sugawara, H; Tobise, K | 1 |
| Ichihara, K; Kamei, H; Miyake, H; Miyoshi, K; Nagasaka, M | 1 |
| Avdonin, V; Hoshi, T; Shibata, EF | 1 |
| Shimamoto, H; Shimamoto, Y | 1 |
| Brauns, T; Glossmann, H; Haugland, RP; Kimball, SD; Prinz, H; Striessnig, J | 1 |
| Fischmeister, R; Hoerter, J; Hove-Madsen, L; Legssyer, AK | 1 |
| Fujiki, H; Hirano, T; Miyakoda, G; Mori, T; Ohura, M; Orito, K | 1 |
| Gan, J; Iuvone, PM | 1 |
| Fukuta, Y; Higashino, R; Inoue, N; Jin, H; Kurimoto, T; Sato, R; Tamaki, H | 1 |
| Balon, TW; Young, JC | 1 |
| Abiko, Y; Ichihara, K; Yokoyama, T | 1 |
| Leng, L; O'Neil, RG | 1 |
| Rao, MR; Xu, Y | 1 |
| Nakagawa, M; Sasaki, S | 1 |
| López-Novoa, JM; Macías, JF; Valdivielso, JM | 1 |
| Bossi, M; Tiberti, G | 1 |
| Ichihara, K; Kamei, H; Kanda, A; Kanno, T; Miyake, H; Miyoshi, K; Nagasaka, M; Okumura, K | 1 |
| Conlin, PR; Williams, GH | 1 |
| Arnoux, A; Cannon, R; Hammond, C; Kordon, C; Kwiecien, R; Robert, C; Vigues, S | 1 |
| Aiello, M; Gambale, F; Moran, O; Pisciotta, M | 1 |
| Ouadid-Ahidouch, H | 1 |
| van Zwieten, PA | 1 |
| Kanaya, N; Kawana, S; Kimura, H; Matsumoto, M; Miyamoto, A; Namiki, A; Ohshika, H; Tsuchida, H | 1 |
| Masumiya, H; Shigenobu, K; Shijuku, T; Tanaka, H | 1 |
| Ishimitsu, T; Kawano, Y; Matsuoka, H; Minami, J; Numabe, A | 1 |
| Hisa, H; Kimura, T; Nagayama, T; Satoh, S; Suzuki-Kusaba, M; Yoshida, M | 1 |
| Atchison, WD; Hewett, SJ; Xu, YF | 1 |
| Bosnjak, ZJ; Fujita, S; Roerig, DL; Stowe, DF | 1 |
| Aicardi, G; Bisi, A; Budriesi, R; Campana, G; Chiarini, A; Rampa, A; Spampinato, S; Valenti, P; Zaza, A | 1 |
| Cena, C; Di Stilo, A; Ermondi, G; Gasco, A; Gasco, AM; Visentin, S | 1 |
| Ishizaki, T; Kudo, S; Miyamoto, G; Okumura, H | 1 |
| Huang, BS; Leenen, FH | 1 |
| Evans, GJ; Pocock, JM | 1 |
| Ahtee, L; Kivastik, T; Piepponen, TP; Zharkovsky, A | 1 |
| Adrián, MJ; Coca, A; Ribera, L; Sánchez, M; Sobrino, J; Torres, M | 1 |
| Hoischen, S; Hullin, R; Reuter, H; Schwinger, RH | 1 |
| Guertin, PA; Hounsgaard, J | 1 |
| Fujii, Y; Kamibayashi, M; Miyazaki, H; Nagashima, K; Nomura, Y; Okuma, Y; Shimizu, K; Tanaka, S; Uehara, T | 1 |
| Arabidze, GG; Birkenhäger, WH; Bulpitt, CJ; Celis, H; de Leeuw, P; Dollery, CT; Duggan, J; Fagard, RH; Fletcher, AE; Gasowski, J; Kawecka-Jaszcz, K; Leonetti, G; Nachev, C; Rodico, JL; Rosenfeld, J; Safar, M; Seux, ML; Staessen, JA; Thijs, L; Tuomilehto, J; Webster, J; Yodfat, Y | 1 |
| Gao, X; Gillman, MW; Goldman, L; Hertzmark, E; McLaughlin, TJ; Ross-Degnan, D; Soumerai, SB; Spiegelman, D | 1 |
| Grant, KA; Green, KL | 1 |
| Bisenieks, E; Briede, J; Daija, D; Duburs, G; Makarova, N; Poikans, J; Uldriķis, J | 1 |
| Kurisu, S; Ozono, R; Teranishi, Y; Tsuru, H; Ueda, A; Yoshimizu, A | 1 |
| Hattori, Y; Irie, M; Takeda, S; Ueshiba, H | 1 |
| Kimura, R; Uchida, S; Urayama, A; Yamada, S | 1 |
| Karasawa, A; Kobayashi, S; Kosaka, N; Nito, M; Nomura, H; Sonoda, R; Tanaka, H; Yamaguchi, K | 1 |
| Alvarez, U; Duncan, R; Harter, L; Hruska, K; Kizer, N | 1 |
| Gonon, A; Nordlander, M; Rydén, L; Segawa, D; Sjöquist, PO; Wang, QD | 1 |
| Kaneko, S; Shou, I; Takeda, M; Takizawa, H; Tomino, Y | 1 |
| Drew, T; Jinnah, HA; Kim, BS; Rothstein, JD; Visser, JE; Yitta, S | 1 |
| Fukuo, K; Morimoto, S; Niinobu, T; Ogihara, T; Suhara, T; Yang, J | 1 |
| Matsuda, Y; Tsukuda, E | 1 |
| Botta, L; Masetto, S; Perin, P; Soto, E; Valli, P; Vega, R; Zucca, G | 1 |
| Doris, PA; Kähönen, M; Kalliovalkama, J; Pekki, A; Pörsti, I; Tolvanen, JP; Voipio, J; Wu, X; Ylitalo, P | 1 |
| Hoshide, S; Ikeda, U; Kario, K; Mitsuhashi, T; Shimada, K | 1 |
| Funabiki, K; Gohda, T; Shike, T; Shirato, I; Tashiro, K; Tomino, Y | 1 |
| Hori, M; Horio, M; Imai, E; Moriyama, T; Sugiura, T | 1 |
| Arora, KK; Diedrich, K; Katzur, AC; Ortmann, O; Schultze-Mosgau, A; Stojilkovic, SS | 1 |
| Hohenegger, M; Kress, HG; Weigl, LG | 1 |
| Armas-Hernández, MJ; Armas-Padilla, MC; Carvajal, AR; Castillo-Moreno, A; Hernández-Hernández, R; Pacheco, B; Velasco, M | 1 |
| Protas, L; Robinson, RB | 1 |
| Akashi, T; Harada, M; Hosoya, T; Ikeda, K; Nakagawa, O; Nakao, K; Tojo, K; Tokudome, G | 1 |
| Hayashi, M; Nakazato, Y; Saruta, T; Yamaji, Y | 1 |
| Dirksen, RT; O'Connell, KM | 1 |
| Koga, K; Mori, T; Ohura, M; Sogabe, T; Tominaga, M; Yabuuchi, Y | 1 |
| Bito, H; Boutillier, AL; Loeffler, JP; Sée, V | 1 |
| Bosnjak, ZJ; Contney, SJ; Kwok, CS; Nicolosi, AC; Olinger, GN | 1 |
| Kan, E; Kelly, JE; Lokuta, AJ; Nishio, M; Sagawa, K; Sagawa, T; Tsai, J; Wasserstrom, JA | 1 |
| Gerzanich, V; Simard, JM; West, GA; Zhang, F | 1 |
| Kakinoki, S; Kitabatake, A; Nomura, A; Takechi, S | 1 |
| Mielcarek, J | 1 |
| Bidet, M; Martial, S; Martin, D; Melendez, E; Namorado, MD; Poujeol, C; Poujeol, P; Reyes, JL; Sanchez, E; Tauc, M; Valencia, L | 1 |
| Hara, H; Sasaoka, M; Shimazawa, M; Sugiyama, T; Toriu, N | 1 |
| Cathala, L; Chesnoy-Marchais, D | 1 |
| Abe, S; Hashimoto, M; Oashi, K; Saikai, T; Suzuki, K; Tanaka, H; Tanaka, S; Teramoto, S | 1 |
| Fukuda, N; Hu, WY; Kanmatsuse, K; Su, JZ | 1 |
| Alcocer, L; Armas-Hernández, MJ; Armas-Padilla, MC; Hernández-Hernández, R; Lezama, E; Velasco, M | 1 |
| Assenat, E; Drocourt, L; Fabre, JM; Maurel, P; Pascussi, JM; Vilarem, MJ | 1 |
| Hayashi, K; Honda, M; Kubota, E; Matsuda, H; Okubo, K; Ozawa, Y; Saruta, T; Tokuyama, H | 1 |
| MacGregor, GA; Missouris, CG; Sirker, A | 1 |
| Hayashi, K; Honda, M; Kubota, E; Matsuda, H; Okubo, K; Ozawa, Y; Saruta, T; Takamatsu, I; Tokuyama, H | 1 |
| Ballester, RM; Lluch, S; Martínez-León, JB; Medina, P; Otero, E; Segarra, G; Vila, JM | 1 |
| Cornélissen, G; Halberg, F; Kubo, Y; Ohkawa, S; Otsuka, K; Shinagawa, M | 1 |
| Kimura, R; Nakajima, M; Uchida, S; Yamada, S | 1 |
| Brown, G; Losonczy, G; Schoenl, M; Venuto, R | 1 |
| Analuie, N; Esmaeeli, F; Foroumadi, A; Javanmardi, K; Najafipour, H; Rezvanipour, M; Sepehri, G; Sepehri, H | 1 |
| Devereux, RB; Palmieri, V | 1 |
| Kimura, R; Kusaka, T; Nakajima, M; Uchida, S; Yamada, S | 1 |
| Farkas, S; Gunics, G; Harsukh, G; Kawase, M; Molnár, J; Motohashi, N; Shah, A | 1 |
| Ansaloni, L; Bernabè, A; Gardini, G; Ghetti, R; Riccardi, R; Tranchino, RM | 1 |
| Szász, G | 1 |
| Dierkes, PW; Hochstrate, P; Schlue, WR; Schoppe, J | 1 |
| Campagnola, M; Cominacini, L; Davoli, A; Fratta Pasini, A; Garbin, U; Lo Cascio, V; Nava, C; Pastorino, AM; Rossato, P | 1 |
| Corradi, L; Derosa, G; Fogari, R; Mugellini, A; Preti, P; Rinaldi, A; Zoppi, A | 1 |
| Fukuchi, M; Iwasaki, T; Masai, M; Naruse, H; Ohyanagi, M; Sakaki, T; Takahashi, K | 1 |
| Shigemasa, M; Takami, T | 1 |
| Bellinghieri, G; Mazzaglia, G; Santoro, D; Savica, V | 1 |
| Inomata, K; Tanaka, H | 1 |
| Shigematsu, M; Takami, T | 1 |
| Camara, AK; Chen, Q; Rhodes, SS; Riess, ML; Stowe, DF | 1 |
| Dondoni, A; Massi, A | 1 |
| Boffi, F; Congiu Castellano, A; Dell'Ariccia, M; Grande, S; Marzi, S; Rosi, A; Viti, V | 1 |
| Dohi, Y; Kojima, M; Sato, K; Taniguchi, M; Ueda, R | 1 |
| Enomoto, A; Konda, T; Kondo, N; Takahara, A | 1 |
| Görlitzer, K; Meyer, H | 1 |
| Inoue, S; Tomino, Y | 1 |
| Kanmatsuse, K; Koike, M; Kushiro, T; Otsuka, Y; Saito, F; Takahashi, A; Watanabe, N | 1 |
| Handler, J | 1 |
| Honda, A; Ishiguro, M; Russell, SR; Tranmer, BI; Wellman, GC; Wellman, TL | 1 |
| Belluti, F; Bisi, A; Budriesi, R; Chiarini, A; Gobbi, S; Ioan, P; Piazzi, L; Rampa, A; Valenti, P | 1 |
| Nakamura, K; Takeuchi, M; Yamagishi, S | 1 |
| Brixius, K; Geissler, HJ; Gross, T; Hekmat, K; Mehlhorn, U; Schwinger, RH; Tossios, P | 1 |
| Chen, ZY; Gollasch, M; Huang, Y; Ko, WH; Leung, FP; Leung, HS; Yao, X | 1 |
| Barclay, LR; Ingold, KU; Lin, S; Litwinienko, G; MacLean, PD; Mulder, P | 1 |
| Higashi, Y; Ishida, M; Ishida, T; Kambe, M; Miho, N; Oshima, T; Ozono, R; Teragawa, H; Yano, Y; Yoshizumi, M | 1 |
| Alipour, E; Davood, A; Mansouri, N; Rerza Dehpour, A; Shafaroudi, H; Shafiee, A | 1 |
| Ambudkar, SV; Bates, SE; Robey, RW; Shukla, S | 1 |
| Alloatti, G; Bonafé, F; Gallo, MP; Levi, R; Losano, G; Marcantoni, A; Pagliaro, P; Penna, C; Ramella, R | 1 |
| Hadama, T; Kaku, T; Lee, TS; Miyamoto, S; Ono, K; Perez-Reyes, E; Takebayashi, S; Uchino, T | 1 |
| Ichikawa, H; Katada, K; Kokura, S; Kon, T; Manabe, H; Naito, Y; Nakabe, N; Shimozawa, M; Yoshida, N; Yoshikawa, T | 1 |
| Mielcarek, J; Naskrent, M | 1 |
| Delgado, F; Ferrara, JT; Juan, ER; Miranda, R; Osnaya, R; Pliego, RG; Villalobos-Molina, R | 1 |
| Horii, M; Imagawa, K; Iwama, H; Kawata, H; Nakajima, T; Naya, N; Okayama, S; Saito, Y; Somekawa, S; Uemura, S | 1 |
| Matsui, T; Nakamura, K; Yamagishi, S | 1 |
| Ikeda, J; Matsubara, M; Yao, K | 1 |
| Arimoto, T; Harada, M; Kitahara, T; Koyama, Y; Kubota, I; Niizeki, T; Sasaki, T; Shishido, T; Suzuki, S; Takahashi, H; Takeishi, Y | 1 |
| Ferrara, A; Fusi, F; Gorelli, B; Kawase, M; Molnar, J; Motohashi, N; Saponara, S; Sgaragli, G; Shah, A | 1 |
| Iwasaki, H; Nakamura, Y; Sugiyama, A; Takahara, A | 1 |
| Chua, YL; Li, G; Liao, P; Soon, JL; Soong, TW; Yong, TF; Yu, D | 1 |
| Fujiwara, H; Hattori, A; Hiei, K; Io, K; Kato, T; Kawasaki, M; Matsuo, H; Minatoguchi, S; Morita, N; Nishigaki, K; Noda, T; Ojio, S; Ono, H; Sato, H; Segawa, T; Takemura, G; Tanaka, T; Ueno, K; Watanabe, S | 1 |
| Berenshteĭn, NV; Burmistrova, LF; Iskenderov, BG; Lokhina, TV | 1 |
| Barrios, V; Calderón, A; de la Figuera, M; Escobar, C; Honorato, J; Llisterri, JL; Segura, J | 2 |
| Cheng, G; Peng, W; Tang, J; Zhao, R; Zhu, R | 1 |
| Arioka, I; Dohi, S; Sakai, K | 1 |
| Furuno, M; Higaki, J; Horiuchi, M; Inaba, S; Iwai, M; Kanno, H; Mogi, M; Okayama, H; Senba, I; Tomono, Y | 1 |
| Kimura, K; Konno, Y | 1 |
| Hemmateenejad, B; Jafarpour, M; Javidnia, K; Miri, R; Tabarzad, M | 1 |
| Ball, CJ; Beltrame, JF; Saint, DA; Turner, SP; Wilson, DP | 1 |
| Godfraind, T | 1 |
| Fujimoto, S; Horike, H; Kashihara, N; Nagasu, H; Sasaki, T; Satoh, M | 1 |
| Iwata, S; Koganei, H; Shoji, M | 1 |
| Aizawa, T; Fujimoto, Y; Ishiwata, S; Matsuno, S; Nakamura, M; Oikawa, Y; Ono, T; Yajima, J | 1 |
| Futenma, A; Imai, H; Kimura, Y; Maeda, K; Miura, N; Suga, N; Yamada, H | 1 |
| Lee, YH; Li, CL; Lu, HK; Tseng, CC; Wang, LF | 1 |
| Cao, S; Chang, CC; Dunne, SF; Kai, L; Kang, S; Luan, CH; Pandey, P; Silverman, RB; Surmeier, DJ; Tian, X | 1 |
| Kitakaze, M; Liao, YL; Luo, Q; Xi, F; Xuan, WL | 1 |
| Chen, C; Shaikh, AC | 1 |
| Chen, ZW; Fan, L; Furnary, A; Grove, KL; He, GW; Huang, Y; Xiao, XQ; Yang, Q | 1 |
| Fukumoto, Y; Inoue, Y; Minatoguchi, S; Nishigaki, K; Shimokawa, H; Sueda, S; Urata, H; Yamanouchi, Y; Yasuda, S | 1 |
| Ceron, CS; Gerlach, RF; Guimaraes, DA; Marçal, DM; Martins-Oliveira, A; Rizzi, E; Tanus-Santos, JE | 1 |
| Hayashi, T; Inoue, T; Ishizaka, N; Kitada, K; Kitaura, Y; Kurumazuka, D; Matsuda, H; Matsumura, Y; Mori, T; Nagatoya, K; Ukimura, A | 1 |
| Piñeros, MA; Tester, M | 1 |
| Barbier, O; Bidet, M; Martial, S; Melendez, E; Poujeol, P; Reyes, JL; Sanchez, E; Tauc, M | 1 |
| de Almeida Kiguti, LR; Pupo, AS | 1 |
| Bhuva, V; Dholariya, B; Dodiya, D; Kataria, V; Shah, V; Trivedi, A | 1 |
| Deguchi, K; Hitomi, H; Kitaura, Y; Kobori, H; Lei, B; Masaki, T; Mori, H; Mori, T; Nagai, Y; Nakano, D; Nishiyama, A | 1 |
| Gil Cunquero, JM; Gutiérrez Rivas, PC; Liébana Cañada, A; Merino García, E; Viñolo López, MC | 1 |
| Davood, A; Dehpoor, AR; Iman, M; Nematollahi, AR; Shafiee, A | 1 |
| Aritomi, S; Konda, T; Yoshimura, M | 1 |
| Arakawa, K; Fujii, M; Inoki, I; Kimura, T; Konoshita, T; Makino, Y; Miyamori, I; Morikawa, N; Nakamura, H; Wakahara, S | 1 |
| Chattipakorn, N; Chattipakorn, S; Chinda, K; Fucharoen, S; Kumfu, S | 1 |
| Cernecka, H; Krenek, P; Mensikova, L; Svetlik, J; Veizerova, L | 1 |
| DeDea, L | 1 |
| Chen, YC; Lee, HW; Li, CL; Lin, SJ; Lu, HK; Wang, LF | 1 |
| Krzemiński, TF; Mitręga, KA; Porc, M; Varghese, B | 1 |
| Kazama, I; Maruyama, Y; Matsubara, M | 1 |
| Agabiti Rosei, E; De Ciuceis, C; Di Gregorio, J; Donini, C; Flati, V; La Boria, E; Pasini, E; Petroboni, B; Porteri, E; Rizzoni, D; Rossini, C; Rufo, A | 1 |
| Kamiya, A; Kawada, T; Miyazaki, S; Shimizu, S; Sugimachi, M; Turner, MJ; Yamamoto, H | 1 |
| Enyeart, JA; Enyeart, JJ | 1 |
| Damen, CW; González, O; Hankemeier, T; van der Kloet, FM; van Vliet, M; Vreeken, RJ | 1 |
| D'Angelo, A; Derosa, G; Franzetti, I; Maffioli, P; Mugellini, A; Pesce, RM; Querci, F | 1 |
| Cropper, EC; Evans, CG; Svensson, E | 1 |
| Ando, K; Egi, K; Fujioka, S; Fukuda, S; Hosaka, S; Izumi-Nakaseko, H; Minh, PN; Mizoue, T; Nagasaka, S; Nakamura, Y; Sugiyama, A; Takazawa, K; Toguchi, K; Wada, T | 1 |
| El-Hamamsy, MH; El-Moselhy, TF; Saleh, DO; Shaldam, MA | 1 |
| Chudoba, D; Drużbicki, K; Jarek, M; Jenczyk, J; Kiwilsza, A; Mielcarek, J; Pajzderska, A; Wąsicki, J | 1 |
| Bisenieks, E; Duburs, G; Gall Troselj, K; Krauze, A; Poikans, J; Velena, A; Zarkovic, N | 1 |
| D'Angelo, A; Derosa, G; Maffioli, P; Mugellini, A; Pesce, RM | 1 |
| Ando, K; Cao, X; Izumi-Nakaseko, H; Nakamura, Y; Saitoh, M; Sugiyama, A; Takahara, A; Wada, T; Xu, B; Zhu, B | 1 |
| Komabayashi, G; Matsui, T; Nguyen, HN; Tanaka, M | 1 |
| Beuhler, MC; Kerns, WP; Murphy, CM; Nicholson, B; Quinn, ME; Shoe, T; Williams, C | 1 |
| de Vries, C; Haerden, Y; Lins, R | 1 |
| Ding, WG; Dubel, S; Mangoni, ME; Matsuura, H; Mesirca, P; Striessnig, J; Toyoda, F | 1 |
| Bao, J; Mei, X; Wang, JR; Yan, Z; Yu, Q | 1 |
| Acone, B; Calcullo, C; Crippa, M; De Luca, N; Desideri, G; Gaudio, GV; Lonati, LM; Orselli, L; Roca, E; Scuteri, A; Tocci, G; Vulpis, V; Zaninelli, A | 1 |
| Hosaka, S; Tokunaga, Y | 1 |
| Harding, SE; Maxwell, LJ; Pope, J; Rirash, F; Tanjong Ghogomu, E; Tingey, PC; Tugwell, P; Wells, GA | 1 |
| Aimoto, M; Cao, X; Ishiguro, A; Nagasawa, Y; Nozaki, S; Okamura, K; Takahara, A | 1 |
| Caglayan, MG; Dogan-Topal, B; Karadurmus, L; Ozkan, SA; Shah, A; Shahzad, S; Taskin Tok, T; Uslu, B | 1 |
| Kestur, US; Mugheirbi, NA; Saboo, S; Taylor, LS; Zemlyanov, DY | 1 |
| Cabrera, DDC; D'Oca, MGM; de Oliveira, MWB; Gonçalves, CAN; Machado, KDS; Nery, LEM; Santa-Helena, E; Scaini, JLR; Werhli, AV | 1 |
| Bender, A; Chen, X; Li, Y; Meng, Q; Yang, J; Zhang, Y | 1 |
| Banh, HL; Cave, A; Kung, JY; Liang, L; Mitchelmore, B | 1 |
| Hojnacki, D; Podolsky, R; Schaller, B; Sternberg, Z; Tian, M; Yu, J | 1 |
24 review(s) available for nifedipine and dihydropyridines
| Article | Year |
|---|---|
New drugs for hypertension--variations on old themes.
Topics: Amlodipine; Antihypertensive Agents; Delayed-Action Preparations; Dihydropyridines; Doxazosin; Humans; Hypertension; Isradipine; Nifedipine; Prazosin; Verapamil | 1991 |
Modulation of calcium channel function by drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Electric Conductivity; Heart Rate; Homeostasis; Humans; Ion Channels; Membrane Potentials; Nifedipine; Pyridines; Receptors, Cell Surface; Structure-Activity Relationship | 1985 |
Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic beta-Agonists; Animals; Calcium; Dihydropyridines; In Vitro Techniques; Ion Channels; Isoproterenol; Kinetics; Models, Biological; Nifedipine; Phosphorylation; Pyridines; Receptors, Adrenergic, beta | 1986 |
Beta-adrenoceptor antagonists plus nifedipine in the treatment of chronic stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Chronic Disease; Dihydropyridines; Drug Therapy, Combination; Humans; Nifedipine | 1989 |
Differential effects of 1,4-dihydropyridine calcium channel blockers: therapeutic implications.
Topics: Angina Pectoris; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Hemodynamics; Humans; Hypertension; Nifedipine; Nitrendipine | 1987 |
"Calcium antagonists": a class of drugs with a bright future. Part II. Determination of basic pharmacological properties.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Electrophysiology; Heart Rate; Ion Channels; Lanthanum; Methods; Muscle, Smooth; Myocardial Contraction; Nifedipine; Potassium; Pyridines; Receptors, Adrenergic, alpha; Stereoisomerism; Verapamil | 1984 |
Are dihydropyridine binding sites voltage sensitive calcium channels?
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Ion Channels; Muscle, Smooth; Muscles; Myocardium; Neurons; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Pyridines | 1984 |
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cerebrovascular Circulation; Cerebrovascular Disorders; Coronary Disease; Diabetes Mellitus; Dihydropyridines; Female; Humans; Hypertension; Ketamine; Magnesium; Magnesium Deficiency; Microcirculation; Muscle, Smooth, Vascular; Muscles; Nifedipine; Nisoldipine; Nitrendipine; Nutritional Requirements; Pentobarbital; Pre-Eclampsia; Pregnancy; Pyridines; Rats; Vasoconstrictor Agents; Vasodilator Agents; Venules | 1984 |
Nifedipine. Dose-related increase in mortality in patients with coronary heart disease.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Confidence Intervals; Coronary Disease; Depression, Chemical; Dihydropyridines; Dose-Response Relationship, Drug; Hemorrhage; Humans; Hypotension; Myocardial Contraction; Myocardial Ischemia; Nifedipine; Odds Ratio; Renin-Angiotensin System; Sympathetic Nervous System; Time Factors | 1995 |
Trough:peak ratio of the blood pressure response to dihydropyridine calcium antagonists. Italian Nifedipine GITS Study Group.
Topics: Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Dihydropyridines; Humans; Hypertension; Nifedipine | 1994 |
Grapefruit juice and drugs. How significant is the interaction?
Topics: Beverages; Biological Availability; Citrus; Dihydropyridines; Drug Interactions; Felodipine; Flavanones; Flavonoids; Half-Life; Humans; Nifedipine; Nitrendipine | 1994 |
Lipophilic dihydropyridines provide renal protection from cyclosporin toxicity.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Cyclosporine; Dihydropyridines; Humans; Kidney; Kidney Transplantation; Nifedipine | 1993 |
Pharmacology of the dihydropyridine calcium antagonists: relationship between lipophilicity and pharmacodynamic responses.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Humans; Hypertension; In Vitro Techniques; Models, Biological; Nifedipine | 1993 |
Similarities and differences between calcium antagonists: pharmacological aspects.
Topics: Angina Pectoris; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Humans; Hypertension; Nifedipine; Vasodilator Agents; Verapamil | 1993 |
Short acting dihydropyridine (vasodilating) calcium channel blockers for hypertension: is there a risk?
Topics: Calcium Channel Blockers; Case-Control Studies; Clinical Trials as Topic; Dihydropyridines; Humans; Hypertension; Myocardial Ischemia; Nifedipine; Sensitivity and Specificity | 1996 |
[Calcium channel blocker for therapy of patients with hypertension].
Topics: Benzimidazoles; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Humans; Hypertension; Mibefradil; Nifedipine; Tetrahydronaphthalenes; Thiazoles | 1997 |
Use of calcium channel blockers in hypertension.
Topics: Antihypertensive Agents; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Case-Control Studies; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Heart Diseases; Humans; Hypertension; Longitudinal Studies; Mibefradil; Nifedipine; Public Health; Randomized Controlled Trials as Topic; Risk Factors; Tetrahydronaphthalenes; Vasodilator Agents; Verapamil | 1998 |
Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Guinea Pigs; Hypertension; Nifedipine; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1998 |
Angiotensin converting enzyme inhibition and dihydropyridine calcium channel blockade in the treatment of left ventricular hypertrophy in arterial hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Diuretics; Drug Therapy, Combination; Enalapril; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Meta-Analysis as Topic; Nifedipine; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Time Factors; Ventricular Dysfunction, Left | 2002 |
Prognostic effects of calcium channel blockers in patients with vasospastic angina--a meta-analysis.
Topics: Amlodipine; Angina Pectoris; Asian People; Calcium Channel Blockers; Coronary Vasospasm; Dihydropyridines; Diltiazem; Humans; Nifedipine; Prognosis; Treatment Outcome | 2010 |
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.
Topics: Amlodipine; Animals; Antioxidants; Azetidinecarboxylic Acid; Calcium Channel Blockers; Cattle; Dihydropyridines; Epithelial Cells; Humans; Hydrogen; Lipoproteins, LDL; Mice; Microsomes; Mitochondria; Niacinamide; Nifedipine; Nitrobenzenes; Oxidants; Oxidative Stress; Piperazines | 2016 |
How to Improve Effectiveness and Adherence to Antihypertensive Drug Therapy: Central Role of Dihydropyridinic Calcium Channel Blockers in Hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Essential Hypertension; Humans; Medication Adherence; Nifedipine; Risk Factors; Treatment Outcome; Vasodilator Agents | 2018 |
Calcium channel blockers for primary and secondary Raynaud's phenomenon.
Topics: Calcium Channel Blockers; Dihydropyridines; Humans; Nifedipine; Pain Management; Placebos; Publication Bias; Randomized Controlled Trials as Topic; Raynaud Disease; Severity of Illness Index | 2017 |
Comparative peripheral edema for dihydropyridines calcium channel blockers treatment: A systematic review and network meta-analysis.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Edema; Humans; Hypertension; Network Meta-Analysis; Nifedipine | 2022 |
39 trial(s) available for nifedipine and dihydropyridines
| Article | Year |
|---|---|
[Comparative hypotensive effectiveness of various calcium antagonists in patients with persistent essential hypertension (randomized study)].
Topics: Blood Pressure; Calcium Channel Blockers; Chronic Disease; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Stroke Volume | 1992 |
Hemodynamic effects of isradipine and nifedipine in chronic sustained hypertension.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Isradipine; Middle Aged; Nifedipine | 1992 |
Differential effects of two dihydropyridine calcium antagonists in humans.
Topics: Administration, Oral; Adult; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Dihydropyridines; Dose-Response Relationship, Drug; Heart Rate; Humans; Infusions, Intravenous; Male; Nifedipine | 1992 |
First clinical experience with isradipine in the treatment of hypertension in Portugal.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Isradipine; Male; Middle Aged; Nifedipine; Portugal | 1991 |
Comparative study of lacidipine and nifedipine SR in the treatment of hypertension: an Italian multicenter study. The Northern Italian Study Group of Lacidipine in Hypertension.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Italy; Male; Middle Aged; Nifedipine | 1991 |
[The hemodynamic effects of isradipine and nifedipine in hypertension].
Topics: Adult; Blood Pressure; Cardiac Output; Dihydropyridines; Female; Heart; Heart Function Tests; Humans; Hypertension; Injections, Intravenous; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine; Propranolol; Stroke Volume | 1991 |
Acute and chronic effects of dihydropyridines on triglycerides in humans.
Topics: Adult; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine; Random Allocation; Triglycerides | 1988 |
Haemodynamic parameters in hypertensive patients: changes induced by lacidipine and nifedipine.
Topics: Adult; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Randomized Controlled Trials as Topic; Time Factors | 1989 |
Calcium antagonist antihypertensive treatment of non-insulin-dependent diabetics: efficacy and safety of lacidipine versus nifedipine SR.
Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Cholesterol; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Triglycerides | 1994 |
A long-term study comparing lacidipine and nifedipine SR in hypertensive patients: safety data.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Single-Blind Method | 1994 |
Effects of lacidipine and nifedipine on lower limb veins in nonphlebopathic patients.
Topics: Adult; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Leg; Male; Middle Aged; Nifedipine; Regional Blood Flow; Ultrasonography, Doppler, Color; Veins | 1994 |
The use of lacidipine in the management of hypertensive crises: a comparative study with nifedipine.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Emergency Medical Services; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1994 |
Effects of manidipine hydrochloride on blood pressure in hypertensive patients--a comparison with nifedipine retard.
Topics: Adult; Aged; Blood Pressure; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrobenzenes; Piperazines | 1993 |
Altered hypothalamic-pituitary-adrenal axis responsiveness in myotonic dystrophy: in vivo evidence for abnormal dihydropyridine-insensitive calcium transport.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Biological Transport; Calcium; Child; Dihydropyridines; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Middle Aged; Myotonic Dystrophy; Naloxone; Nifedipine; Pituitary-Adrenal System; Reference Values | 1993 |
Benidipine counteracts sodium-induced alterations in systemic and regional hemodynamics.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Nifedipine; Regional Blood Flow; Single-Blind Method; Sodium, Dietary | 1997 |
Comparison of 24-hour blood pressure, heart rate, and autonomic nerve activity in hypertensive patients treated with cilnidipine or nifedipine retard.
Topics: Autonomic Pathways; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine | 1998 |
Long-acting lacidipine versus short-acting nifedipine in the treatment of asymptomatic acute blood pressure increase.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Diastole; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Reference Values; Single-Blind Method; Systole; Treatment Outcome | 1999 |
Systolic Hypertension in Europe (Syst-Eur) trial phase 2: objectives, protocol, and initial progress. Systolic Hypertension in Europe Investigators.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Determination; Calcium Channel Blockers; Dihydropyridines; Drug Administration Schedule; Drug Therapy, Combination; Enalapril; Europe; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Nifedipine; Prognosis; Survival Rate; Treatment Outcome | 1999 |
Cilnidipine, the N- and L-type calcium channel antagonist, reduced on 24-h urinary catecholamines and C-peptide in hypertensive non-insulin-dependent diabetes mellitus.
Topics: Aged; C-Peptide; Calcium Channel Blockers; Catecholamines; Chromatography, High Pressure Liquid; Cross-Over Studies; Diabetes Mellitus, Type 2; Dihydropyridines; Dopamine; Epinephrine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Norepinephrine | 1999 |
Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension.
Topics: Arachidonic Acid; Biomarkers; Blood Platelets; Blood Pressure; Calcium Channels; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Nifedipine; Platelet Aggregation; Posture; Single-Blind Method | 2000 |
Effects of short- and long-acting calcium channel blockers on the relationship between blood pressure and physical activity.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Cross-Over Studies; Dihydropyridines; Exercise; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Systole | 2001 |
Effects of candesartan on cough and bronchial hyperresponsiveness in mildly to moderately hypertensive patients with symptomatic asthma.
Topics: Adult; Aged; Antihypertensive Agents; Asthma; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bronchial Hyperreactivity; Calcium Channel Blockers; Cough; Dihydropyridines; Female; Genetic Testing; Humans; Hypertension; Incidence; Male; Methacholine Chloride; Middle Aged; Nifedipine; Nitrobenzenes; Pain Measurement; Peptidyl-Dipeptidase A; Piperazines; Polymorphism, Genetic; Respiratory Function Tests; Tetrazoles; Treatment Outcome | 2001 |
Impact of circadian amplitude and chronotherapy: relevance to prevention and treatment of stroke.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Calcium Channel Blockers; Chronotherapy; Circadian Rhythm; Cross-Over Studies; Dihydropyridines; Electrocardiography, Ambulatory; Female; Humans; Male; Middle Aged; Nifedipine; Stroke | 2001 |
Oral lacidipine in the treatment of anal fissure.
Topics: Administration, Oral; Adult; Aged; Calcium Channel Blockers; Dihydropyridines; Female; Fissure in Ano; Follow-Up Studies; Humans; Male; Middle Aged; Nifedipine; Pain; Pain Measurement; Prospective Studies; Time Factors | 2002 |
Differential effects of lercanidipine and nifedipine GITS on plasma norepinephrine in chronic treatment of hypertension.
Topics: Adult; Aged; Calcium Channel Blockers; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Norepinephrine | 2003 |
Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Ankle; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Brachial Artery; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Male; Nifedipine; Pulsatile Flow; Tetrazoles; Thiazepines; Treatment Outcome; Valine; Valsartan | 2003 |
Effects of manidipine and nifedipine on blood pressure and renal function in patients with chronic renal failure: a multicenter randomized controlled trial.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nifedipine; Nitrobenzenes; Piperazines; Treatment Outcome; Urinary Tract Physiological Phenomena | 2003 |
Effects of calcium channel antagonists on left ventricular hypertrophy and diastolic function in patients with essential hypertension.
Topics: Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diastole; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nifedipine | 2003 |
Antihypertensive effects of long-acting calcium channel blockers on hemodialysis days--a randomized crossover trial between benidipine and nifedipine CR.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cross-Over Studies; Delayed-Action Preparations; Dihydropyridines; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nifedipine; Renal Dialysis | 2004 |
Effects of calcium antagonists in hypertensive patients with renal dysfunction: a prospective, randomized, parallel trial comparing benidipine and nifedipine.
Topics: Calcium Channel Blockers; Dihydropyridines; Disease Progression; Female; Humans; Hypertension; Hypertension, Renovascular; Male; Middle Aged; Nifedipine; Prospective Studies | 2004 |
Beneficial effect of T-type calcium channel blockers on endothelial function in patients with essential hypertension.
Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Calcium Channel Blockers; Case-Control Studies; Dihydropyridines; Endothelial Cells; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrophenols; Organophosphorus Compounds; Vasodilation | 2005 |
Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Calcium Channel Blockers; Calcium Channels, T-Type; Cross-Over Studies; Depression, Chemical; Dihydropyridines; Hemodynamics; Humans; Male; Neurotransmitter Agents; Nifedipine; Nitrophenols; Organophosphorus Compounds; Renin; Water-Electrolyte Balance | 2006 |
[Hypotensive efficacy and tolerability of combination of dihydropyridine and non-dihydropyridine calcium antagonists in the treatment of patients with arterial hypertension].
Topics: Adult; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nifedipine; Obesity; Treatment Outcome; Verapamil | 2007 |
High doses of lercanidipine are better tolerated than other dihydropyridines in hypertensive patients with metabolic syndrome: results from the TOLERANCE study.
Topics: Adolescent; Adult; Aged; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Cross-Sectional Studies; Dihydropyridines; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Male; Metabolic Syndrome; Middle Aged; Nifedipine | 2008 |
Tolerability of high doses of lercanidipine versus high doses of other dihydropyridines in daily clinical practice: the TOLERANCE Study.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Sectional Studies; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Logistic Models; Male; Middle Aged; Nifedipine; Primary Health Care; Spain; Vasodilation | 2008 |
Effects of treatment with once-daily nifedipine CR and twice-daily benidipine on prevention of symptomatic attacks in patients with coronary spastic angina pectoris-Adalat Trial vs Coniel in Tokyo against Coronary Spastic Angina (ATTACK CSA).
Topics: Acetylcholine; Angina Pectoris; Blood Pressure; Coronary Vasospasm; Dihydropyridines; Electrocardiography, Ambulatory; Ergonovine; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nitrates; Vasodilator Agents | 2010 |
A crossover comparison of urinary albumin excretion as a new surrogate marker for cardiovascular disease among 4 types of calcium channel blockers.
Topics: Aged; Aged, 80 and over; Albuminuria; Biomarkers; Calcium Channel Blockers; Cardiovascular Diseases; Cross-Over Studies; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine | 2013 |
Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial.
Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Echocardiography; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Losartan; Male; Middle Aged; Nifedipine; Treatment Outcome | 2015 |
Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Biomarkers; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hypertension; Italy; Losartan; Male; Middle Aged; Nifedipine; Oxidative Stress; Time Factors; Treatment Outcome | 2016 |
412 other study(ies) available for nifedipine and dihydropyridines
| Article | Year |
|---|---|
Antihypertensive effects of MPC-1304, a novel calcium antagonist, in experimental hypertensive rats and dogs.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Heart Rate; Hypertension; Hypertension, Renal; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Wistar | 1992 |
Cardioprotective effects of nicorandil.
Topics: Animals; Benzopyrans; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Neutrophils; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Rats; Rats, Sprague-Dawley; Reperfusion; Superoxides | 1992 |
Low dihydropyridine receptor density in vasa deferentia of castrated rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Male; Membranes; Nifedipine; Orchiectomy; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Vas Deferens | 1992 |
Stereoselective pharmacodynamic action of (+)-S-12967 and (-)-S-12968, isomers of a new slow acting 1,4-dihydropyridine derivative with calcium channel agonistic and antagonistic effects on rat aorta.
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; In Vitro Techniques; Male; Nifedipine; Potassium Chloride; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship; Vasoconstriction | 1992 |
A sustained occupancy in vivo of cardiovascular calcium antagonist receptors by mepirodipine and its relation to pharmacodynamic effect in spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Blood Pressure; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Hypertension; Isradipine; Male; Myocardium; Nifedipine; Rats; Rats, Inbred SHR; Receptors, Nicotinic | 1992 |
Haemodynamic effects of a new dihydropyridine calcium entry blocker, S-12968-(-), in a rat model of cardiovascular calcium overload.
Topics: Animals; Blood Pressure; Body Weight; Calcium; Calcium Channel Blockers; Cardiac Output; Cholecalciferol; Dihydropyridines; Heart Rate; Hemodynamics; Magnesium; Male; Nicotine; Nifedipine; Nitroprusside; Rats; Stereoisomerism; Vascular Resistance | 1992 |
Voltage-dependent L-type calcium channels in the development and plasticity of mouse barrel cortex.
Topics: Aging; Animals; Autoradiography; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Isradipine; Kinetics; Mice; Neuronal Plasticity; Nifedipine; Somatosensory Cortex; Tritium; Vibrissae | 1992 |
[Use of spectral characteristics of ryodipine in the study of dihydropyridine receptor complex of neuronal membranes].
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dihydropyridines; In Vitro Techniques; Male; Molecular Probes; Nifedipine; Rats; Rats, Wistar; Spectrometry, Fluorescence; Synaptosomes | 1992 |
Background calcium permeable channels in glomerulosa cells from adrenal gland.
Topics: Aldosterone; Animals; Biological Transport; Calcium; Calcium Channels; Cattle; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Electric Conductivity; Membrane Potentials; Nifedipine; Rats; Zona Glomerulosa | 1992 |
Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters.
Topics: Aging; Allosteric Site; Animals; Calcium Channels; Cricetinae; Dihydropyridines; Diltiazem; In Vitro Techniques; Kinetics; Male; Myocardium; Nifedipine; Verapamil | 1992 |
Effects of the calcium antagonist manidipine on renal hemodynamics and function in dogs: comparison with nifedipine.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Female; Hemodynamics; Kidney; Lithium; Male; Nifedipine; Nitrobenzenes; Piperazines; Renal Circulation; Sodium; Urine | 1992 |
Effect of calcium channel blockers on postprandial gastrointestinal motility in the dog.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Eating; Electromyography; Female; Gastrointestinal Motility; Hemodynamics; Nifedipine | 1992 |
Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arteries; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; Drug Antagonism; Heart; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Nifedipine; Radioligand Assay; Rats | 1992 |
Cardiovascular effects of a novel calcium entry blocking and selective beta 1-adrenoceptor blocking agent, YM-16151-4, in anesthetized and conscious dogs.
Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Atenolol; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; Hemodynamics; Male; Nifedipine; Nitrophenols; Vagotomy; Vasodilator Agents | 1992 |
Gonadotropin-releasing hormone-induced calcium signaling in clonal pituitary gonadotrophs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Cell Line; Dihydropyridines; Endoplasmic Reticulum; Gonadotropin-Releasing Hormone; Ionomycin; Nifedipine; Pituitary Gland; Potassium; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Absence of a direct coupling of a G protein to dihydropyridine binding sites in rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium Channels; Dihydropyridines; GTP-Binding Proteins; Heart; Male; Myocardium; Nicardipine; Nifedipine; Rats; Rats, Wistar | 1992 |
Isradipine and other calcium channel antagonists attenuate ethanol consumption in ethanol-preferring rats.
Topics: Alcohol Drinking; Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Ethanol; Isradipine; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Evidence for the presence of regional differences in the calcium antagonist receptors in lower urinary tract smooth muscle.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Carbachol; Dihydropyridines; Drug Interactions; Female; Isradipine; Muscle Contraction; Muscle, Smooth; Nifedipine; Rabbits; Urinary Tract | 1992 |
Synthesis and cardiovascular properties of furazanyl-1,4-dihydropyridines and of furoxanyl analogues.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Cardiovascular Agents; Dihydropyridines; Female; Guinea Pigs; Heart Rate; Heterocyclic Compounds; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine | 1992 |
Excitation-contraction coupling in a pre-vertebrate twitch muscle: the myotomes of Branchiostoma lanceolatum.
Topics: Animals; Blotting, Western; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cell Movement; Chordata, Nonvertebrate; Dihydropyridines; Membrane Potentials; Microsomes; Muscle Contraction; Nifedipine; Ryanodine; Verapamil | 1992 |
Comparative cytoprotective effect of dihydropyridine calcium channel blockers against the toxicity of oxidized low density lipoprotein for cultured lymphoid cells.
Topics: Calcium Channel Blockers; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Lipid Peroxidation; Lipoproteins, LDL; Lymphocytes; Nicardipine; Nifedipine; Nimodipine; Nisoldipine | 1992 |
Cardiovascular effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[(cyclopropylamino)carbonyl]-1,4-dihydro-2,6-dimethyl-4-(2-nitropheny l) octyl ester.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart Conduction System; Hemodynamics; In Vitro Techniques; Male; Nicardipine; Nifedipine; Rabbits; Vasodilator Agents | 1992 |
[Amlodipine: pharmacokinetic and pharmacodynamic profile of a calcium antagonist with prolonged effect].
Topics: Amlodipine; Angina Pectoris; Animals; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Humans; Nifedipine; Structure-Activity Relationship | 1992 |
Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Cholesterol; Dihydropyridines; Diltiazem; Electrons; Isradipine; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nitrendipine; Phosphatidylcholines; Rabbits; Verapamil | 1992 |
Comparative studies of the systemic hemodynamics and myocardial oxygen consumption of FRC 8653, a new Ca++ channel blocker, and nifedipine in anesthetized dogs.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Myocardium; Nifedipine; Oxygen Consumption | 1992 |
Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice.
Topics: Adult; Aged; Animals; Beverages; Citrus; Dihydropyridines; Felodipine; Flavanones; Flavonoids; Humans; Male; Microsomes, Liver; Middle Aged; Nifedipine; Quercetin; Rats; Rats, Inbred Strains; Stereoisomerism | 1992 |
Effect of voltage-sensitive calcium channel antagonists on the release of 5-hydroxytryptamine from rat hippocampus in vivo.
Topics: Animals; Calcium; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Male; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Rats; Rats, Inbred Strains; Serotonin; Verapamil | 1992 |
Spin-trapping and antioxidant properties of illuminated and nonilluminated nifedipine and nimodipine in heart homogenate and model system.
Topics: Animals; Antioxidants; Dihydropyridines; Electron Spin Resonance Spectroscopy; Free Radicals; Heart; Light; Lipid Peroxidation; Nifedipine; Nimodipine; Rats | 1991 |
Block of L-type calcium channels by charged dihydropyridines. Sensitivity to side of application and calcium.
Topics: Amlodipine; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Diffusion; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Nifedipine; Nisoldipine; Receptors, Nicotinic | 1991 |
Calcium-dependent control of volume regulation in renal proximal tubule cells: II. Roles of dihydropyridine-sensitive and -insensitive Ca2+ entry pathways.
Topics: Animals; Biological Transport; Calcium; Calcium Channels; Cell Membrane Permeability; Dihydropyridines; Hypotonic Solutions; Ion Channel Gating; Kidney Tubules, Proximal; Microscopy, Fluorescence; Nifedipine; Rabbits; Verapamil | 1991 |
A molecular model involving the membrane bilayer in the binding of lipid soluble drugs to their receptors in heart and brain.
Topics: 1,2-Dipalmitoylphosphatidylcholine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amlodipine; Animals; Brain; Cholesterol; Dihydropyridines; Gels; Lipid Bilayers; Membranes; Models, Chemical; Models, Molecular; Myocardium; Nifedipine; Rats; Receptors, Drug; Sarcolemma; Solubility | 1990 |
Calcium release from pituitary secretory granules: modulation by thiols, disulfides, and dihydropyridine calcium channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cattle; Cysteine; Cystine; Cytoplasmic Granules; Dihydropyridines; Disulfides; Dithiothreitol; Glutathione; Hydrogen-Ion Concentration; Mercaptoethanol; Nifedipine; Nimodipine; Pituitary Gland; Potassium Chloride; Sulfhydryl Compounds | 1990 |
Two subtypes of dihydropyridine-sensitive calcium channels in rat ventricular muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium Channel Agonists; Calcium Channels; Dihydropyridines; Female; Heart; In Vitro Techniques; Magnesium; Male; Myocardial Contraction; Myocardium; Nifedipine; Potassium Chloride; Pyridines; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum | 1990 |
The effects of strychnine on the regulation of voltage-dependent calcium channels by dihydropyridines in brain and heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium; Calcium Channels; Dihydropyridines; Drug Interactions; Heart; Male; Mice; Myocardial Contraction; Myocardium; Nifedipine; Phencyclidine; Potassium; Rats; Rats, Inbred Strains; Sodium; Strychnine | 1990 |
Comparative behavioral, neurochemical and pharmacological activities of dihydropyridine calcium channel activating drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium Channel Agonists; Catecholamines; Chromatography, High Pressure Liquid; Dihydropyridines; Guinea Pigs; Injections, Intraperitoneal; Male; Mice; Motor Activity; Muscle Contraction; Muscle, Smooth; Nicotinic Acids; Nifedipine; Oxadiazoles; Pyridines; Stereoisomerism; Structure-Activity Relationship | 1990 |
Involvement of dihydropyridine-sensitive Ca2+ channels in adenosine-evoked inhibition of acetylcholine release from guinea pig ileal preparation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Acetylcholine; Adenosine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Calcium Channels; Chromatography, High Pressure Liquid; Dihydropyridines; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle, Smooth; Nifedipine; Physostigmine; Tetrodotoxin; Theophylline | 1990 |
Dihydropyridine actions on calcium currents of frog sympathetic neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Dihydropyridines; In Vitro Techniques; Kinetics; Membrane Potentials; Neurons; Nifedipine; Rana catesbeiana; Rana pipiens; Sympathetic Nervous System | 1990 |
The effects of dihydropyridine calcium channel modulators on pentylenetetrazole convulsions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amlodipine; Animals; Anticonvulsants; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Male; Mice; Nifedipine; Nimodipine; Seizures | 1990 |
Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Absorption; Animals; Biological Transport; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Dihydropyridines; Epithelium; Exocytosis; Kidney Tubules, Distal; Kinetics; Mice; Microtubules; Nifedipine; Parathyroid Hormone; Peptide Fragments | 1990 |
Inhibition of adenosine responses of rat hippocampal neurones by nifedipine and BAYK 8644.
Topics: 2-Chloroadenosine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine; Animals; Dihydropyridines; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Neurons; Nifedipine; Pyramidal Tracts; Rats | 1990 |
Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Caffeine; Dihydropyridines; Evoked Potentials; Female; Hippocampus; In Vitro Techniques; Light; Membrane Potentials; Neurons; Nifedipine; Nimodipine; Perfusion; Potassium; Pyramidal Tracts; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission | 1990 |
Hypoxic suppression of K+ currents in type I carotid body cells: selective effect on the Ca2(+)-activated K+ current.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Calcium Channel Blockers; Carotid Body; Dihydropyridines; Electrophysiology; Hypoxia; Nifedipine; Potassium; Rats | 1990 |
Dihydropyridines alter adenosine sensitivity in the rat hippocampal slice.
Topics: 2-Chloroadenosine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dihydropyridines; Dipyridamole; Evoked Potentials; Hippocampus; In Vitro Techniques; Magnesium; Male; Nifedipine; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission; Vasodilator Agents | 1990 |
Involvement of dihydropyridine-sensitive calcium channels in the GABAA potentiation of TRH-induced TSH release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; GTP-Binding Proteins; In Vitro Techniques; Isonicotinic Acids; Male; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Pertussis Toxin; Pituitary Gland; Pyridazines; Rats; Rats, Inbred Strains; Thyrotropin; Thyrotropin-Releasing Hormone; Virulence Factors, Bordetella | 1990 |
Calcium currents in the A7r5 smooth muscle-derived cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Biological Transport; Calcium; Calcium Channels; Cell Line; Colforsin; Cytosol; Dihydropyridines; Electric Conductivity; Fluorescence; Isoproterenol; Ligands; Muscle, Smooth, Vascular; Nifedipine; Potassium | 1990 |
Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Cadmium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Dihydropyridines; Electric Conductivity; Membrane Potentials; Nifedipine; Pertussis Toxin; Verapamil; Virulence Factors, Bordetella | 1991 |
[Single calcium channels from the membranes of the adrenal medullary substance].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium Channels; Cattle; Cell Membrane; Dihydropyridines; In Vitro Techniques; Ion Channel Gating; Lipid Bilayers; Male; Membrane Lipids; Membrane Potentials; Membrane Proteins; Nifedipine; Solubility; Time Factors | 1991 |
Permeation of Pb2+ through calcium channels: fura-2 measurements of voltage- and dihydropyridine-sensitive Pb2+ entry in isolated bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium Channels; Cattle; Cell Membrane Permeability; Cell Separation; Dihydropyridines; Fura-2; Lead; Membrane Potentials; Nifedipine | 1991 |
The hemodynamic effects of lacidipine in anesthetized dogs: comparison with nitrendipine, amlodipine, verapamil, and diltiazem.
Topics: Amlodipine; Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Nifedipine; Nitrendipine; Stroke Volume; Vascular Resistance; Verapamil | 1991 |
Electrophysiological effects of CD-349, a dihydropyridine-type calcium antagonist, on goat cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Dihydropyridines; Electrophysiology; Goats; In Vitro Techniques; Microelectrodes; Nifedipine; Nitrendipine; Purkinje Fibers | 1991 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium Channel Blockers; Cerebellum; Dihydropyridines; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Isradipine; Kainic Acid; Nerve Degeneration; Nervous System Diseases; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Remodeling of left ventricular geometry and function induced by lacidipine and nifedipine SR in mild-to-moderate hypertension.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Heart Rate; Heart Ventricles; Humans; Hypertension; Male; Middle Aged; Models, Cardiovascular; Nifedipine; Ultrasonography; Ventricular Function, Left | 1991 |
Pharmacological characteristics of NP-252, a new dihydropyridine slow Ca2+ channel blocker, in isolated rabbit vascular smooth muscle and guinea pig myocardium: vascular selectivity.
Topics: Action Potentials; Angiotensin II; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Female; Guinea Pigs; Heart; Histamine; In Vitro Techniques; Lanthanum; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Nifedipine; Norepinephrine; Potassium; Rabbits; Serotonin | 1991 |
Effect of TC-81, a new dihydropyridine derivative, on K(+)-induced contraction in rat aorta.
Topics: Animals; Aorta; Calcium; Calcium Radioisotopes; Dihydropyridines; Diltiazem; In Vitro Techniques; Isometric Contraction; Male; Nicardipine; Nifedipine; Papaverine; Potassium; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilator Agents | 1991 |
Antagonistic effects of dihydropyridines and verapamil on CaCl2 and 5-HT-evoked contraction in porcine coronary artery.
Topics: Animals; Calcium Chloride; Coronary Vessels; Dihydropyridines; Felodipine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Nimodipine; Serotonin Antagonists; Swine; Verapamil | 1991 |
Prolonged inhibition of vascular contraction and calcium influx by the novel 1,4-dihydropyridine calcium antagonist cinaldipine (FRC-8653).
Topics: Animals; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Rats; Rats, Inbred Strains; Time Factors; Vasodilator Agents | 1991 |
Vasoinhibitory effect of NP-252, a new dihydropyridine derivative, in canine cerebral artery.
Topics: Animals; Calcium; Cerebral Arteries; Coronary Vessels; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Drug Resistance; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Potassium Chloride; Thromboxane A2 | 1991 |
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme System; Dihydropyridines; Felodipine; Humans; Kinetics; Microsomes, Liver; Nifedipine; Norpregnenes; Oxidation-Reduction | 1991 |
Cardiovascular properties of LF 2.0254, a new potent vasoselective calcium channel blocker with a slow onset of action.
Topics: Anesthesia; Animals; Calcimycin; Calcium Channel Blockers; Calcium Chloride; Calcium Radioisotopes; Dihydropyridines; Dogs; Female; Guinea Pigs; Heart; Hemodynamics; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits; Rats | 1990 |
Omega-conotoxin GVIA and dihydropyridines discriminate two types of Ca2+ channels involved in GABA release from striatal neurons in culture.
Topics: Calcium Channels; Cells, Cultured; Corpus Striatum; Dihydropyridines; gamma-Aminobutyric Acid; Kinetics; Mollusk Venoms; Neurons; Nifedipine; omega-Conotoxin GVIA | 1990 |
Binding of [125I]iodipine to parathyroid cell membranes: evidence of a dihydropyridine-sensitive calcium channel.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Iodine Radioisotopes; Iodobenzenes; Kinetics; Ligands; Nicotinic Acids; Nifedipine; Oxadiazoles; Parathyroid Glands; Stereoisomerism | 1990 |
Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Dihydropyridines; Hippocampus; Male; Morphine Dependence; Naloxone; Nifedipine; Nitrendipine; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Substance Withdrawal Syndrome | 1990 |
Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Evoked Potentials; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardium; Nerve Block; Nifedipine; Substance Withdrawal Syndrome | 1990 |
Control of calcium channels in neuroblastoma cells (N1E-115).
Topics: Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Humans; Neuroblastoma; Nifedipine; Parathyroid Hormone; Tumor Cells, Cultured | 1990 |
Contributions of two types of calcium channels to synaptic transmission and plasticity.
Topics: Action Potentials; Animals; Aplysia; Cadmium; Calcium Channels; Cells, Cultured; Dihydropyridines; Electric Conductivity; FMRFamide; Motor Neurons; Neuronal Plasticity; Neurons, Afferent; Neuropeptides; Nifedipine; Serotonin; Synapses; Synaptic Transmission | 1990 |
Receptor model for the molecular basis of tissue selectivity of 1, 4-dihydropyridine calcium channel drugs.
Topics: Amino Acid Sequence; Binding Sites; Calcium Channel Blockers; Calcium Channels; Computer Simulation; Dihydropyridines; Drug Design; Models, Molecular; Molecular Conformation; Molecular Structure; Nifedipine; Receptors, Nicotinic; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
Mechanisms of endothelin-induced augmentation of the electrical and mechanical activity in rat portal vein.
Topics: Animals; Biomechanical Phenomena; Dihydropyridines; Electrophysiology; Endothelins; Endothelium, Vascular; Ions; Nifedipine; Peptides; Portal Vein; Rats; Rats, Inbred Strains; Vasoconstriction | 1990 |
Calcium channel blockers reverse the sustained elevation of blood pressure induced by chronic infusion of endothelin in conscious rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Endothelins; Hypertension; Male; Nifedipine; Peptides; Rats; Rats, Inbred Strains; Sodium | 1990 |
Effects of Ca2+ channel agonist-antagonist enantiomers of dihydropyridine 202791 on insulin release, 45Ca uptake and electrical activity in isolated pancreatic islets.
Topics: Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Female; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Molecular Conformation; Nifedipine; Rats; Rats, Inbred Strains | 1990 |
Synthesis, pharmacological effects, and conformation of 4,4-disubstituted 1,4-dihydropyridines.
Topics: Animals; Antihypertensive Agents; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; Models, Molecular; Molecular Conformation; Muscle, Smooth, Vascular; Nifedipine; Rabbits | 1990 |
Determination of 2,6-dimethyl-4-(2'-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethylester in nifedipine by derivative UV-spectrophotometry in bulk material and pharmaceutical forms.
Topics: Dihydropyridines; Indicators and Reagents; Nifedipine; Solutions; Spectrophotometry, Ultraviolet; Tablets | 1990 |
High and low affinity states of the dihydropyridine and phenylalkylamine receptors on the cardiac calcium channel and their interconversion by divalent cations.
Topics: Animals; Calcium; Cations, Divalent; Chickens; Dihydropyridines; Heart; Ion Channels; Isradipine; Magnesium; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1985 |
Stimulation of calcium uptake in PC12 cells by the dihydropyridine agonist BAY K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Gland Neoplasms; Animals; Calcium; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Nifedipine; Nitrendipine; Pheochromocytoma; Pyridines; Rats | 1985 |
Decreased [3H]nitrendipine binding in the brainstem of deoxycorticosterone-NaCl hypertensive rats.
Topics: Animals; Brain Stem; Calcium; Desoxycorticosterone; Dihydropyridines; Hypertension; Ion Channels; Kidney; Kinetics; Male; Myocardium; Nephrectomy; Nifedipine; Nitrendipine; Organ Size; Pyridines; Rats; Sodium Chloride | 1985 |
Profile of the oppositely acting enantiomers of the dihydropyridine 202-791 in cardiac preparations: receptor binding, electrophysiological, and pharmacological studies.
Topics: Animals; Binding, Competitive; Calcium; Dihydropyridines; Dogs; Electric Conductivity; Guinea Pigs; Heart; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Nitrendipine; Papillary Muscles; Pyridines; Sarcolemma; Stereoisomerism; Ventricular Function | 1985 |
Effects of nitrendipine on the voltage-sensitive calcium channel in mammalian sensory neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Dihydropyridines; Electric Stimulation; Ethanol; Ganglia, Spinal; Ion Channels; Mice; Nerve Growth Factors; Neurons, Afferent; Nifedipine; Nitrendipine; Pharmaceutical Vehicles; Pyridines; Reaction Time; Temperature | 1985 |
The calcium agonists Bay K 8644 and (+)202,791 stimulate the release of endothelial relaxing factor from canine femoral arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Dihydropyridines; Dogs; Endothelium; Femoral Artery; In Vitro Techniques; Ion Channels; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Pyridines | 1985 |
The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aminoquinolines; Animals; Brain Chemistry; Calcium; Calcium Channel Blockers; Cell Line; Dihydropyridines; Electric Stimulation; Glioma; In Vitro Techniques; Ion Channels; Neuroblastoma; Neurons; Nifedipine; Potassium; Pyridines; Rats; Synaptosomes; Verapamil | 1986 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
Ca2+-channel current and its modification by the dihydropyridine agonist BAY k 8644 in isolated smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Barium; Barium Compounds; Cell Membrane; Cesium; Chlorides; Dihydropyridines; Guinea Pigs; Ileum; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscle, Smooth; Nifedipine; Pyridines | 1986 |
Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bucladesine; Calcium; Cell Differentiation; Dihydropyridines; Nerve Growth Factors; Nifedipine; Nitrendipine; Norepinephrine; Pheochromocytoma; Potassium; Pyridines; Rats; Secretory Rate | 1986 |
Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dihydropyridines; Ion Channels; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Nitrendipine; Pyridines; Rats | 1986 |
o-Isothiocyanate dihydropyridine (oNCS-DHP), a long-acting, reversible inhibitor of the Ca++ channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Drug Stability; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Heart; In Vitro Techniques; Isothiocyanates; Kinetics; Muscle Contraction; Nifedipine; Tritium | 1986 |
Blockade of Ca2+ and K+ currents in bag cell neurons of Aplysia californica by dihydropyridine Ca2+ antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aplysia; Calcium; Calcium Channel Blockers; Dihydropyridines; Ion Channels; Kinetics; Mathematics; Neurons; Nifedipine; Nisoldipine; Potassium; Pyridines | 1987 |
Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential-dependent blockade by Ro 18-3981.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Female; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Isradipine; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Oxadiazoles; Potassium; Pyridines | 1987 |
Photoaffinity labelling of the cardiac calcium channel. (-)-[3H]azidopine labels a 165 kDa polypeptide, and evidence against a [3H]-1,4-dihydropyridine-isothiocyanate being a calcium-channel-specific affinity ligand.
Topics: Affinity Labels; Animals; Azides; Calcium; Cell Membrane; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Heart; Hexobendine; Ion Channels; Isothiocyanates; Myocardium; Nicardipine; Nifedipine; Peptides; Pyridines; Rats; Species Specificity; Thiocyanates | 1987 |
Cardiovascular actions of a new dihydropyridine calcium antagonist, 8363-S: comparison with nifedipine and nicardipine in awake, unsedated dogs.
Topics: Administration, Oral; Animals; Calcium Channel Blockers; Cardiovascular System; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Injections, Intravenous; Nicardipine; Nifedipine; Pyridines | 1987 |
MDL 72567, a dihydropyridine calcium-antagonist, that causes vasodilation and direct sinus bradycardia.
Topics: Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Decerebrate State; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Hypertension, Renal; Male; Nicotinic Acids; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Vasodilation | 1987 |
Dihydropyridine inhibition of neuronal calcium current and substance P release.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Chickens; Dihydropyridines; Electric Stimulation; Ganglia, Spinal; Ion Channels; Kinetics; Neurons; Nifedipine; Pyridines; Substance P | 1987 |
Comparison between the effects of MDL 72567 and nifedipine on various cardiovascular parameters in conscious sinoaortic-denervated rats and sham-operated controls.
Topics: Animals; Blood Pressure; Denervation; Dihydropyridines; Electrocardiography; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Nifedipine; Pressoreceptors; Rats; Rats, Inbred Strains; Sympathectomy | 1987 |
Effect of daunorubicin on dihydropyridine-sensitive binding sites in cardiac sarcolemma.
Topics: Animals; Calcium; Cricetinae; Daunorubicin; Dihydropyridines; Female; In Vitro Techniques; Ion Channels; Isradipine; Male; Myocardial Contraction; Myocardium; Nifedipine; Oxadiazoles; Sarcolemma | 1987 |
Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Chick Embryo; Dihydropyridines; Electric Stimulation; Ganglia, Spinal; Nifedipine; Substance P | 1988 |
Modulation of neurotransmitter metabolism by dihydropyridine calcium channel ligands in mouse brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dihydropyridines; Dopamine; Drug Interactions; Homovanillic Acid; Hydroxyindoleacetic Acid; Ion Channels; Male; Mice; Neurotransmitter Agents; Nifedipine | 1988 |
Interaction between Bay-K-8644 and various relaxant agents on K+-depolarized contracture of guinea pig taenia coli.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Colon; Dihydropyridines; Diltiazem; Ethanol; Gallopamil; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Nifedipine; Papaverine; Potassium | 1988 |
Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Rabbits; Rats; Time Factors | 1987 |
The iminodipropionitrile (IDPN)-induced dyskinetic syndrome in mice: antagonism by the calcium channel antagonist nifedipine.
Topics: Animals; Binding Sites; Brain; Calcium; Dihydropyridines; Dyskinesia, Drug-Induced; Female; Ion Channels; Mice; Nifedipine; Nitriles | 1988 |
Cardiovascular profile of FPL 62129, a novel dihydropyridine calcium channel blocker, in anaesthetised dogs: a comparison with nifedipine.
Topics: Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Dihydropyridines; Dogs; Female; Heart Rate; Male; Nifedipine; Regional Blood Flow; Vascular Resistance | 1988 |
Pharmacology of BMY 20064, a potent Ca2+ entry blocker and selective alpha 1-adrenoceptor antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Drug Combinations; Hemodynamics; In Vitro Techniques; Male; Nifedipine; Prazosin; Rabbits; Rats; Rats, Inbred Strains | 1988 |
Comparative binding of two closely related dihydropyridines (isradipine and darodipine) to serum proteins and erythrocytes.
Topics: Binding, Competitive; Blood Proteins; Calcium Channel Blockers; Dihydropyridines; Erythrocytes; gamma-Globulins; Humans; Isradipine; Lipoproteins; Nifedipine; Pyridines | 1988 |
Relationship of dihydropyridine binding sites with calcium-dependent neurotransmitter release in synaptosomes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Aminopyridines; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; gamma-Aminobutyric Acid; Ion Channels; Isradipine; Lanthanum; Male; Mice; Neurotransmitter Agents; Nifedipine; Nitrendipine; Oxadiazoles; Potassium; Receptors, Nicotinic; Ruthenium Red; Synaptosomes | 1988 |
[Central control of the baroreflex response to phenylephrine by dihydropyridines in the anesthetized rat].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Calcium; Calcium Channels; Dihydropyridines; Heart Rate; Hypertension; Nifedipine; Phenylephrine; Pressoreceptors; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Nicotinic; Sympathetic Nervous System | 1988 |
Dual effect of dihydropyridines on 45Ca uptake induced by the K+ -channel blocker, 4-aminopyridin on mast cells.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Dihydropyridines; Female; Histamine Release; Ion Channels; Mast Cells; Nifedipine; Nisoldipine; Potassium; Rats; Rats, Inbred Strains | 1988 |
Activation of dihydropyridine-sensitive calcium channels and biphasic cytosolic calcium responses by angiotensin II in rat adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium; Calcium Channels; Cattle; Cytosol; Dihydropyridines; Ethers; Ionomycin; Kinetics; Male; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Species Specificity; Spectrometry, Fluorescence; Zona Glomerulosa | 1988 |
Regulation of voltage-dependent excitatory responses to alpha,beta-methylene ATP, ATP and non-adrenergic nerve stimulation by dihydropyridines in the guinea-pig vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Adenosine Triphosphate; Adrenergic Fibers; Animals; Calcium; Calcium Channels; Dihydropyridines; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Nifedipine; Vas Deferens | 1988 |
Reduction of K+-stimulated 45Ca2+ influx in synaptosomes with age involves inactivating and noninactivating calcium channels and is correlated with temporal modifications in protein dephosphorylation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aging; Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Dihydropyridines; Kinetics; Male; Molecular Weight; Nifedipine; Phosphoproteins; Phosphorylation; Potassium; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Serotonin modulates calcium-dependent plateau of action potentials recorded from bull frog A-type sensory neurons which is omega-conotoxin GVIA-sensitive, but dihydropyridine-insensitive.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Dihydropyridines; Ganglia, Spinal; In Vitro Techniques; Mollusk Venoms; Neurons, Afferent; Nifedipine; omega-Conotoxin GVIA; Rana catesbeiana; Serotonin; Tetraethylammonium Compounds | 1989 |
A dihydropyridine calcium channel blocker with phosphodiesterase inhibitory activity: effects on cultured vascular smooth muscle and cultured heart cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Depression, Chemical; Dihydropyridines; Dose-Response Relationship, Drug; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Nifedipine; Phosphodiesterase Inhibitors; Rats; Verapamil | 1988 |
Contribution of external and internal Ca2+ to changes in intracellular free Ca2+ produced by mitogens in Swiss 3T3 fibroblasts: the role of dihydropyridine sensitive Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cell Line; Cytosol; Dihydropyridines; Extracellular Space; Fibroblasts; Mice; Mitogens; Nifedipine; Platelet-Derived Growth Factor | 1989 |
Effects of dihydropyridine calcium channel ligands on rat brain gamma-aminobutyric acidB receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Baclofen; Binding, Competitive; Calcium Channels; Dihydropyridines; Male; Nifedipine; Rats; Receptors, GABA-A | 1989 |
Calcium currents in single isolated smooth muscle cells from the rabbit ear artery in normal-calcium and high-barium solutions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channels; Dihydropyridines; Ear; Electric Conductivity; Membrane Potentials; Muscle, Smooth, Vascular; Nifedipine; Rabbits | 1988 |
Interaction between isoproterenol and dihydropyridines in heart cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cells, Cultured; Chick Embryo; Dihydropyridines; Heart; Isoproterenol; Myocardial Contraction; Myocardium; Nicardipine; Nifedipine; Time Factors | 1989 |
Calcium currents in bullfrog sympathetic neurons. I. Activation kinetics and pharmacology.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Cadmium; Calcium Channel Agonists; Calcium Channels; Dihydropyridines; Ganglia, Sympathetic; Kinetics; Membrane Potentials; Neurons; Nifedipine; Rana catesbeiana; Saxitoxin; Second Messenger Systems | 1989 |
Slow onset of and recovery from Ca blocking action of benidipine in rat aorta and portal vein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Portal Vein; Rats; Rats, Inbred Strains | 1989 |
Biotransformation of amlodipine. Identification and synthesis of metabolites found in rat, dog and human urine/confirmation of structures by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry.
Topics: Amlodipine; Animals; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dihydropyridines; Dogs; Gas Chromatography-Mass Spectrometry; Humans; Nifedipine; Rats; Species Specificity | 1989 |
Effects of antihypertensive drugs on renal function and atrial natriuretic polypeptide in spontaneously hypertensive rats with renal ablation.
Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Calcium Channel Blockers; Captopril; Dihydropyridines; Indapamide; Kidney; Male; Nephrectomy; Nifedipine; Rats; Rats, Inbred SHR; Reference Values | 1989 |
Amlodipine, a new 1,4-dihydropyridine calcium antagonist with a particularly strong antihypertensive profile.
Topics: Amlodipine; Animals; Antihypertensive Agents; Arteriosclerosis; Calcium; Calcium Channel Blockers; Dihydropyridines; Heart; In Vitro Techniques; Isoproterenol; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocardium; Nifedipine; Rabbits; Rats; Retinal Artery; Swine; Vasoconstriction | 1989 |
Relaxation of potassium chloride-induced contractions by amlodipine and its interaction with the 1,4-dihydropyridine-binding site in pig coronary artery.
Topics: Amlodipine; Animals; Binding Sites; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Isradipine; Nifedipine; Oxadiazoles; Potassium Chloride; Sarcolemma; Stereoisomerism; Swine; Vasoconstriction; Vasodilation | 1989 |
Evidence of altered dihydropyridine receptor binding capacity following cardiac transplantation.
Topics: Animals; Binding, Competitive; Calcium Channels; Dihydropyridines; Dogs; Graft Rejection; Heart Transplantation; Nifedipine; Nitrendipine; Receptors, Nicotinic; Sarcolemma; Verapamil | 1989 |
Intrasynaptosomal free calcium concentration is increased by phorbol esters via a 1,4-dihydropyridine-sensitive (L-type) Ca2+ channel.
Topics: Animals; Calcium; Calcium Channels; Dihydropyridines; Fluorescent Dyes; In Vitro Techniques; Male; Nicardipine; Nifedipine; Phorbol Esters; Rats; Rats, Inbred Strains; Synaptosomes; Tetradecanoylphorbol Acetate | 1989 |
Modulation of calcium channels by charged and neutral dihydropyridines.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Conductivity; Electrochemistry; Hydrogen-Ion Concentration; Ions; Membrane Potentials; Nifedipine; Protons | 1989 |
Pharmacological characterization of the voltage-dependent calcium channel of pancreatic B-cell.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Glucose; Insulin; Islets of Langerhans; Male; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Osmolar Concentration; Potassium; Potassium Chloride; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Inhibition of histamine release from rat hypothalamic slices by omega-conotoxin GVIA, but not by nilvadipine, a dihydropyridine derivative.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Histamine; Hypothalamus; In Vitro Techniques; Male; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Rats; Rats, Inbred Strains | 1989 |
Interaction between calcium channel ligands and guanine nucleotides in cultured rat sensory and sympathetic neurones.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Gallopamil; Ganglia, Spinal; Ganglia, Sympathetic; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Ligands; Neurons, Afferent; Nifedipine; Rats; Thionucleotides | 1989 |
Some pharmacological applications of an extracellular recording method to study secretion of a sympathetic co-transmitter, presumably ATP.
Topics: Action Potentials; Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Dihydropyridines; Extracellular Space; Guinea Pigs; Male; Methods; Mice; Neuromuscular Junction; Neurotransmitter Agents; Nifedipine; Potassium Channels; Sympathetic Nervous System; Tetrodotoxin; Vas Deferens | 1989 |
Reversible dihydropyridine isothiocyanate binding to brain calcium channels.
Topics: Animals; Brain; Calcium; Dihydropyridines; Ion Channels; Isothiocyanates; Kinetics; Male; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Thiocyanates | 1985 |
Calcium channels in rat brain synaptosomes: identification and pharmacological characterization. High affinity blockade by organic Ca2+ channel blockers.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Ion Channels; Male; Nifedipine; Nitrendipine; Norepinephrine; Potassium; Pyridines; Rats; Rats, Inbred Strains; Synaptosomes | 1985 |
Dihydropyridine sensitive calcium channels in a smooth muscle cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Cell Line; Cobalt; Dihydropyridines; Ion Channels; Muscle, Smooth, Vascular; Nifedipine; Nitrendipine; Potassium; Pyridines; Rats | 1985 |
Effects of S-312, a new calcium antagonist, on the mechanical and electrophysiological responses of isolated cardiovascular preparations.
Topics: Animals; Arteries; Calcium Channel Blockers; Cecum; Dihydropyridines; Electrophysiology; Guinea Pigs; Heart; Heart Conduction System; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nifedipine; Rabbits; Sinoatrial Node; Vasodilation | 1989 |
Natriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electrolytes; Male; Natriuresis; Nicardipine; Nifedipine; Nitrobenzenes; Piperazines; Rats; Rats, Inbred SHR; Renal Circulation; Urodynamics | 1989 |
[The effect of dihydropyridines on the strontium and calcium content in frog muscle].
Topics: Animals; Calcium; Dihydropyridines; In Vitro Techniques; Isotonic Solutions; Muscles; Nifedipine; Pyridines; Rana temporaria; Ringer's Solution; Strontium | 1989 |
Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists.
Topics: Calcium Channel Blockers; Chemotactic Factors; Chemotaxis, Leukocyte; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Interleukins; Kinetics; Lymphocytes; Nifedipine; Recombinant Proteins; Verapamil | 1989 |
Effects of oxodipine on 45Ca movements and contractile responses in vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Radioisotopes; Dihydropyridines; Female; In Vitro Techniques; Isometric Contraction; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Portal Vein; Rats; Rats, Inbred Strains; Time Factors | 1989 |
AK-2-38, a nifedipine analogue with potent smooth muscle calcium antagonist action and partial agonist effects on isolated guinea pig left atrium.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine | 1989 |
Studies directed toward ascertaining the active conformation of 1,4-dihydropyridine calcium entry blockers.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Models, Molecular; Molecular Conformation; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Rabbits; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship | 1988 |
[Molecular tools for the study of calcium channels: synthesis and evaluation of biological activity of new derivatives of 4-aryl-1,4-dihydropyridine groups].
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry; Chromatography, Affinity; Dihydropyridines; Ligands; Nifedipine; Rabbits; Receptors, Nicotinic | 1988 |
[Effect of dihydropyridines on cation transport across the skeletal muscle membrane in the frog].
Topics: Animals; Biological Transport; Calcium Channel Blockers; Calcium Channels; Cell Membrane Permeability; Dihydropyridines; Dose-Response Relationship, Drug; Membrane Potentials; Muscles; Nifedipine; Potassium Channels; Rana esculenta; Rana temporaria | 1988 |
Synthesis and calcium channel antagonist activity of nifedipine analogues containing 1,2-dihydropyridyl in place of the 1,4-dihydropyridyl moiety.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Intestine, Small; Kinetics; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitrendipine; Structure-Activity Relationship | 1988 |
A comparison of the effects of oxodipine and nifedipine on rat vas deferens.
Topics: Animals; Dihydropyridines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Chloride; Rats; Vas Deferens; Vasodilator Agents | 1988 |
In vivo circumvention of vincristine resistance in mice with P388 leukemia using a novel compound, AHC-52.
Topics: Animals; Dihydropyridines; Drug Resistance; Drug Synergism; Female; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Nifedipine; Pyrazoles; Vincristine | 1989 |
Phencyclidine increases the affinity of dihydropyridine calcium channel antagonist binding in rat brain.
Topics: Animals; Binding Sites; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Kinetics; Magnesium; Male; Nifedipine; Nitrendipine; Phencyclidine; Pyridines; Rats; Rats, Inbred Strains | 1985 |
Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents.
Topics: Amlodipine; Animals; Biological Assay; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; Guinea Pigs; Hemodynamics; Kinetics; Male; Nifedipine; Pyridines; Rats; Vasoconstriction | 1986 |
Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dioxanes; Gallopamil; In Vitro Techniques; Nicardipine; Nifedipine; Pyridines; Quinuclidinyl Benzilate; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Nicotinic; Stereoisomerism | 1985 |
Subcellular distribution of dihydropyridine isothiocyanate binding in guinea-pig ileal smooth muscle.
Topics: Animals; Binding Sites; Cell Membrane; Centrifugation, Density Gradient; Digitonin; Dihydropyridines; Electron Transport Complex IV; Guinea Pigs; Ileum; In Vitro Techniques; Isothiocyanates; Muscle, Smooth; NADPH-Ferrihemoprotein Reductase; Nifedipine; Phosphodiesterase I; Phosphoric Diester Hydrolases; Subcellular Fractions | 1985 |
Effect of ryodipine on electromechanical parameters of heart and vessels, cAMP phosphodiesterase activity and swelling-contraction cycle of mitochondria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anura; Calcium Channel Blockers; Cardiovascular Agents; Cattle; Dihydropyridines; Electric Stimulation; Electrophysiology; Heart; In Vitro Techniques; Mitochondria; Mitochondria, Liver; Mitochondrial Swelling; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nifedipine; Pyridines; Rabbits; Rats | 1985 |
Dihydropyridine calcium channel antagonists binding in non-mammalian vertebrates: characterization and relationship to 'peripheral-type' binding sites for benzodiazepines.
Topics: Animals; Brain; Calcium Channels; Columbidae; Dihydropyridines; Female; Kinetics; Lizards; Male; Membranes; Myocardium; Nifedipine; Nitrendipine; Pyridines; Rana catesbeiana; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Nicotinic; Species Specificity; Trout | 1986 |
High-affinity antibodies to the 1,4-dihydropyridine Ca2+-channel blockers.
Topics: Animals; Antibodies; Antibody Specificity; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Nifedipine; Nitrendipine; Pyridines; Rabbits; Receptors, Nicotinic; Structure-Activity Relationship; Tritium | 1986 |
Oxidation of 1,4-dihydropyridines by prostaglandin synthase and the peroxidic function of cytochrome P-450. Demonstration of a free radical intermediate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cytochrome P-450 Enzyme System; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Free Radicals; Glutathione; In Vitro Techniques; Male; Microsomes; Nifedipine; Oxidation-Reduction; Oxygen Consumption; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred Strains | 1986 |
Phosphorylation of ventricular sarcolemmal membranes does not alter binding properties of nitrendipine.
Topics: Alamethicin; Animals; Cats; Dihydropyridines; Dose-Response Relationship, Drug; Female; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Myocardium; Nifedipine; Nitrendipine; Phosphorylation; Protein Kinases; Pyridines; Sarcolemma; Time Factors | 1985 |
Effects of mercaptans upon dihydropyridine binding sites on transverse tubules isolated from triads of rabbit skeletal muscle.
Topics: Animals; Digoxin; Dihydropyridines; Dithiothreitol; Glutathione; Glutathione Disulfide; Muscles; Nifedipine; Nitrendipine; Ouabain; Pyridines; Rabbits; Sulfhydryl Compounds | 1985 |
Gingival hyperplasia in dogs induced by oxodipine, a calcium channel blocking agent.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Female; Gingiva; Gingival Hyperplasia; Male; Nifedipine | 1988 |
Systemic haemodynamics of dihydropyridine derivatives in conscious pigs with or without propranolol.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Hemodynamics; Nifedipine; Nimodipine; Nisoldipine; Propranolol; Swine; Vasodilation | 1988 |
Effect of oxodipine and nifedipine on guinea-pig ileum.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Electric Stimulation; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine | 1988 |
[Anti-angina activity of nifedipine and P0285 in the anesthetized rat].
Topics: Anesthesia; Angina Pectoris; Animals; Calcium Channel Blockers; Dihydropyridines; Electrocardiography; Male; Methacholine Chloride; Methacholine Compounds; Nifedipine; Rats; Rats, Inbred Strains | 1987 |
Effect of the calcium entry blocker NB-818 on cerebral blood flow after unilateral carotid occlusion in the Mongolian gerbil.
Topics: Animals; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Dihydropyridines; Female; Gerbillinae; Injections, Intraperitoneal; Male; Nifedipine; Nimodipine | 1988 |
The antithrombogenic in vivo effects of calcium channel blockers in experimental thrombosis in mice.
Topics: Animals; Calcium Channel Blockers; Collagen; Dihydropyridines; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Epinephrine; Male; Mice; Mice, Inbred Strains; Nifedipine; Thrombosis; Time Factors; Verapamil | 1987 |
Comparative effects of oxodipine and nifedipine in the isolated guinea-pig heart.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Myocardial Contraction; Nifedipine | 1987 |
[Anti-hypertensive activity of P0285 and nifedipine in conscious normotensive rats and in rats with spontaneous, renal and desoxycorticosterone acetate-induced hypertension].
Topics: Animals; Calcium Channel Blockers; Desoxycorticosterone; Dihydropyridines; Heart Rate; Hypertension; Hypertension, Renal; Male; Nifedipine; Rats; Rats, Inbred SHR | 1987 |
Cardiovascular effects of NPK-1886, a new dihydropyridine compound with calcium entry blocking activity.
Topics: Action Potentials; Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Dihydropyridines; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Rate; Hypertension; In Vitro Techniques; Lethal Dose 50; Male; Mice; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Vasoconstriction | 1986 |
Effects of calcium antagonists on phencyclidine behaviors.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Male; Mice; Motor Activity; Motor Skills; Nifedipine; Phencyclidine; Prazosin; Pyridines; Verapamil | 1986 |
Antihypertensive and cardiovascular effects of the new dihydropyridine derivative methyl (E)-3-phenyl-2-propen-1-yl-1,4-dihydro-2,6-dimethyl- 4-(3-nitrophenyl)pyridine-3,5-dicarboxylate.
Topics: Anesthesia, General; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; Heart Rate; Hemodynamics; Hypertension, Renal; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Rabbits; Rats; Rats, Inbred Strains | 1986 |
Quantitative analysis of the dihydropyridines, 3-(2-furoyl)-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)- 1,4-dihydropyridine and nifedipine, by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Dihydropyridines; Dogs; Electrochemistry; Kinetics; Nicotinic Acids; Nifedipine | 1986 |
The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Dihydropyridines; Heart; Kinetics; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Drug; Structure-Activity Relationship; Verapamil | 1986 |
Antihypertensive effects of a new dihydropyridine calcium antagonist.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cats; Dihydropyridines; Dogs; Electrocardiography; Female; Heart Rate; Hypertension, Renal; Male; Nifedipine; Organophosphorus Compounds; Plethysmography; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Species Specificity | 1986 |
Polymorphism of methyl (E)-3-phenyl-2-propen-1-yl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate (FRC-8411).
Topics: Animals; Antihypertensive Agents; Chemical Phenomena; Chemistry, Physical; Crystallization; Dihydropyridines; Male; Nifedipine; Rats; Rats, Inbred SHR; X-Ray Diffraction | 1986 |
Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.
Topics: Animals; Binding Sites; Cattle; Dihydropyridines; Electrophysiology; Heart Conduction System; Ion Channels; Membrane Potentials; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Purkinje Fibers; Pyridines; Verapamil | 1984 |
Comparative structure-activity relationships for dihydropyridines as inhibitors of [3H]-nitrendipine binding vs cyclic nucleotide phosphodiesterases.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Kinetics; Male; Myocardium; Nifedipine; Nitrendipine; Pyridines; Rats; Structure-Activity Relationship | 1984 |
Molecular properties of the slow inward calcium channel. Molecular weight determinations by radiation inactivation and covalent affinity labeling.
Topics: Affinity Labels; Animals; Calcium; Dihydropyridines; Guinea Pigs; Ion Channels; Methods; Molecular Weight; Muscles; Nifedipine; Nitrendipine; Pyridines | 1983 |
Norepinephrine-induced contractions of the rat aorta in the absence of extracellular calcium--II. Effects of calcium antagonists.
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Culture Media; Dihydropyridines; In Vitro Techniques; Indenes; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicotinic Acids; Nifedipine; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Verapamil | 1983 |
Diazepam-stimulated increases in the synaptosomal uptake of 45Ca2+: reversal by dihydropyridine calcium channel antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Chloride; Calcium Radioisotopes; Cerebral Cortex; Diazepam; Dihydropyridines; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Synaptosomes | 1984 |
Crystal structures and pharmacological activity of calcium channel antagonists: 2,6-dimethyl-3,5-dicarbomethoxy-4-(unsubstituted, 2-methyl-, 4-methyl-, 3-nitro-, 4-nitro-, and 2,4-dinitrophenyl)-1,4-dihydropyridine.
Topics: Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Models, Molecular; Molecular Conformation; Nifedipine; Phosphorylcholine; Pyridines; Structure-Activity Relationship; X-Ray Diffraction | 1982 |
Hemodynamic and antiischemic effects of nifedipine, lacidipine, and nisoldipine in rat isolated working heart.
Topics: Animals; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Dihydropyridines; Dose-Response Relationship, Drug; Heart; Hemodynamics; In Vitro Techniques; Male; Mice; Myocardial Ischemia; Nifedipine; Nisoldipine; Rats; Rats, Wistar; Ventricular Function, Left | 1993 |
"Stimulation of dihydropyridine-sensitive Ca2+ influx in cultured myoblasts by 1,25(OH)2-vitamin D3".
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcitriol; Calcium Channels; Cells, Cultured; Chick Embryo; Dihydropyridines; Egtazic Acid; Muscles; Nifedipine; Rats; Rats, Wistar | 1993 |
Dihydropyridine-sensitive initial component of the ANG II-induced Ca2+ response in rat adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium; Calcium Channels, L-Type; Dihydropyridines; Female; Manganese; Membrane Potentials; Muscle Proteins; Nifedipine; Potassium; Rats; Rats, Wistar; Zona Glomerulosa | 1994 |
Modulators of calcium and potassium channels: their effects on endothelin-1 binding to cardiac membranes.
Topics: Animals; Benzopyrans; Calcium Channels; Cromakalim; Dihydropyridines; Endothelins; Heart; In Vitro Techniques; Male; Membranes; Myocardium; Nifedipine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Effects of cyclopiazonic acid on phenylephrine-induced contractions in the rabbit ear artery.
Topics: Animals; Arteries; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Charybdotoxin; Dihydropyridines; Ear; Electrophysiology; Endothelium, Vascular; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Potassium Channel Blockers; Rabbits; Sarcoplasmic Reticulum; Scorpion Venoms | 1994 |
Left ventricular mechanical consequences of dihydropyridine calcium channel modulation in conscious and anesthetized chronically instrumented dogs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthesia; Anesthetics; Animals; Autonomic Nerve Block; Autonomic Nervous System; Calcium Channels; Consciousness; Diastole; Dihydropyridines; Dogs; Drug Interactions; Halothane; Hemodynamics; Isoflurane; Myocardial Contraction; Nifedipine; Systole; Ventricular Function, Left | 1994 |
Effects of nifedipine and Bay K 8644 on contractile activities in single skeletal muscle fibers of the frog.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Adenine; Animals; Caffeine; Calcium; Cell Membrane; Dihydropyridines; Electric Stimulation; Electrophysiology; In Vitro Techniques; Microelectrodes; Muscle Contraction; Muscles; Nifedipine; Potassium; Xenopus laevis | 1994 |
Endogenous DHP-sensitive Ca(2+) channels in Pleurodeles oocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channels; Dihydropyridines; Membrane Potentials; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Oocytes; Peptides; Pleurodeles | 1994 |
Cadmium uptake by kidney distal convoluted tubule cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analysis of Variance; Animals; Cadmium; Calcium; Calcium Channels; Cations, Divalent; Cell Line, Transformed; Dihydropyridines; Kidney Tubules, Distal; Mice; Nifedipine; Parathyroid Hormone | 1994 |
Inhibition of dihydropyridine-sensitive calcium entry in hypoxic relaxation of airway smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bronchi; Calcium; Calcium Channel Blockers; Carbachol; Dihydropyridines; Female; Hypoxia; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Potassium Chloride; Swine | 1995 |
Single-channel properties of four calcium channel types in rat motoneurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium Channels; Dihydropyridines; Hypoglossal Nerve; Motor Neurons; Nerve Tissue Proteins; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Spider Venoms | 1995 |
Evidence that TRH controls prolactin release from rat lactotrophs by stimulating a calcium influx.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Calcium Channels; Cells, Cultured; Culture Media; Cytoplasm; Dihydropyridines; Female; Nifedipine; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Wistar; Thyrotropin-Releasing Hormone | 1994 |
Use of dextran-primed extracorporeal circuit in the canine model for venous return: with special references to the effects of two dihydropyridine-type Ca2+ channel blockers.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dextrans; Dihydropyridines; Dogs; Extracorporeal Circulation; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Nitroglycerin; Norepinephrine | 1995 |
[Calcium channels in bullfrog saccular hair cells].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Dihydropyridines; Hair Cells, Vestibular; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; Rana catesbeiana | 1995 |
Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. II. Modulation of high-voltage-activated calcium currents.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Cell Separation; Cerebral Cortex; Corpus Striatum; Dihydropyridines; Glutamates; Male; Neural Pathways; Nifedipine; Oxcarbazepine; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Presynaptic; Synaptic Transmission | 1995 |
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the responses of isolated canine arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arteries; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Dogs; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Norepinephrine; Potassium Chloride; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Dihydropyridine-like effects of amiodarone and desethylamiodarone on thyrotropin secretion and intracellular calcium concentration in rat pituitary.
Topics: Amiodarone; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Drug Synergism; Male; Nifedipine; Peptide Fragments; Pituitary Gland; Protein Precursors; Rats; Rats, Wistar; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine | 1995 |
Block of non-L-, non-N-type Ca2+ channels in rat insulinoma RINm5F cells by omega-agatoxin IVA and omega-conotoxin MVIIC.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Stimulation; Insulinoma; Kinetics; Nifedipine; omega-Agatoxin IVA; omega-Conotoxins; Pancreatic Neoplasms; Peptides; Rats; Spider Venoms; Tumor Cells, Cultured | 1995 |
Effects of calcium channel blockers on the response to endothelin-1, bradykinin and sodium nitroprusside in porcine ciliary arteries.
Topics: Animals; Arteries; Bradykinin; Calcium Channel Blockers; Ciliary Body; Dihydropyridines; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; In Vitro Techniques; Nifedipine; Nitroprusside; Swine; Vasoconstriction | 1995 |
Residual inhibition in density of [3H]isradipine binding sites in rat brain membrane pretreated with amlodipine.
Topics: Amlodipine; Animals; Binding Sites; Brain; Calcium Channel Blockers; Dihydropyridines; Isradipine; Male; Nifedipine; Oxadiazoles; Radioligand Assay; Rats; Rats, Wistar | 1995 |
Effects of nifedipine and Bay-K-8644 on the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Anesthesia; Animals; Calcium Channels; Dihydropyridines; Dogs; Electric Stimulation; Epinephrine; Female; Male; Nifedipine; Norepinephrine; Sensitivity and Specificity; Splanchnic Nerves | 1993 |
In vitro effects of nifedipine, nisoldipine, and lacidipine on rat isolated coronary small arteries.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Potassium Chloride; Rats; Rats, Wistar; Serotonin Antagonists; Software; Vasoconstriction | 1993 |
Dihydropyridine-sensitive calcium channels expressed in canine colonic smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Cells, Cultured; Colon; Dihydropyridines; Dogs; Female; Ion Channel Gating; Male; Membrane Potentials; Molecular Sequence Data; Muscle, Smooth; Nifedipine; Time Factors | 1993 |
The properties of voltage-operated Ca(2+)-channels in bovine isolated trachealis cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium Channels; Cattle; Cell Membrane; Dihydropyridines; Electrophysiology; In Vitro Techniques; Muscle, Smooth; Nifedipine; Rats; Trachea | 1993 |
Re-evaluation of calcium currents in pre- and postsynaptic neurones of the chick ciliary ganglion.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium Channels; Calcium-Transporting ATPases; Chick Embryo; Ciliary Body; Dihydropyridines; Ion Pumps; Ions; Membrane Potentials; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Schwann Cells; Synapses | 1993 |
Comparison of a calcium antagonist, CD-349, with nifedipine, diltiazem, and verapamil in rabbit spontaneously beating sinoatrial node cells.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Electrophysiology; Female; In Vitro Techniques; Male; Microelectrodes; Nifedipine; Rabbits; Sinoatrial Node; Verapamil | 1993 |
Antianginal effects of YM-16151-4 in various experimental angina models.
Topics: 4-Aminopyridine; Amifampridine; Angina Pectoris; Animals; Arginine Vasopressin; Atrioventricular Node; Calcium Channel Blockers; Coronary Circulation; Coronary Vasospasm; Dihydropyridines; Dogs; Electrocardiography; Female; Heart Conduction System; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitrophenols; Oxygen Consumption; Potassium Channels; Propranolol | 1993 |
Dihydropyridine-sensitive calcium current mediates neurotransmitter release from bipolar cells of the goldfish retina.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Fura-2; Goldfish; In Vitro Techniques; Kinetics; Neurons; Nicardipine; Nifedipine; omega-Conotoxins; Peptides; Retina | 1993 |
[Single channel analysis of Ca2+ channel-agonistic action of dihydropyridine derivatives: voltage-dependent effects of YC-170 and BAY K 8644].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channels; Dihydropyridines; Membrane Potentials; Myocardium; Nifedipine; Rabbits | 1993 |
Cardiovascular effects of YM-16151-4: a novel calcium entry blocking and selective beta 1-adrenoceptor blocking agent in rats and dogs.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dogs; Heart Rate; Hemodynamics; Male; Nifedipine; Nitrophenols; Rats; Rats, Wistar; Renin | 1993 |
Vascular versus myocardial selectivity of dihydropyridine calcium antagonists as studied in vivo and in vitro.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Felodipine; Heart; Heart Rate; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Organ Specificity; Rats; Rats, Inbred SHR | 1995 |
[Edema-inducing properties of lacidipine, nitrendipine and nifedipine in the spontaneously hypertensive rat].
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Edema; Nifedipine; Nitrendipine; Rats; Rats, Inbred SHR; Serum Albumin | 1994 |
Vascular reactivity: a measurement of calcium channel blockade.
Topics: Amlodipine; Angiotensin II; Blood Pressure; Dihydropyridines; Humans; Infusions, Intravenous; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Vasoconstriction | 1995 |
[Pharmacological control of heart rate].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Animals; Benzazepines; Blood Pressure; Calcium Channel Blockers; Cardiovascular Agents; Coronary Circulation; Dihydropyridines; Electrocardiography; Female; Heart Rate; Humans; In Vitro Techniques; Male; Middle Aged; Nifedipine; Population Surveillance; Rabbits; Sinoatrial Node; Tachycardia; Verapamil | 1994 |
Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Dihydropyridines; Electric Conductivity; Female; Ion Channel Gating; Kinetics; Macromolecular Substances; Myocardium; Nifedipine; Nisoldipine; Oocytes; Structure-Activity Relationship; Xenopus laevis | 1995 |
The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic AMP; Cycloleucine; Dihydropyridines; Glutamic Acid; GTP-Binding Proteins; Mice; Neurotoxins; Nifedipine; Pertussis Toxin; Protein Kinases; Receptors, Metabotropic Glutamate; Second Messenger Systems; Up-Regulation; Virulence Factors, Bordetella | 1994 |
Effects of m-nifedipine on dihydropyridine binding sites in cardiac and cerebral cortex cell membranes from left ventricular hypertrophied rats.
Topics: Animals; Binding Sites; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Isomerism; Male; Muscle Proteins; Nifedipine; Rats; Rats, Sprague-Dawley | 1993 |
Role of cyclic GMP in inhibitory effects of CD-349 in isolated blood vessels.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cyclic GMP; Dihydropyridines; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits | 1994 |
Antihypertensive treatment in patients with a history of accelerated malignant hypertension, with special reference to clinical decision-making in changing treatment.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrobenzenes; Piperazines | 1994 |
[Anticonvulsant activity of sodium valproate and various calcium antagonists during their combined use in mice].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Epilepsy; Male; Mice; Nifedipine; Valproic Acid; Verapamil | 1993 |
Blockers of Ca2+ channels in the plasmalemma of perfused Characeae cells.
Topics: Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chlorophyta; Dihydropyridines; Membrane Potentials; Nifedipine; Nitrendipine; Perfusion; Pyridines | 1994 |
Effects of MPC-1304, a novel Ca2+ entry blocker, on alpha-adrenoceptor-mediated pressor responses in pithed rats.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Blood Pressure; Brimonidine Tartrate; Calcium Channel Blockers; Decerebrate State; Dihydropyridines; Electric Stimulation; Nifedipine; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Spinal Cord; Sympathetic Nervous System | 1993 |
Dihydropyridine group of calcium channel antagonist in epilepsy.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electrodes, Implanted; Electroencephalography; Electroshock; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Nifedipine; Phenytoin; Rats; Rats, Wistar | 1994 |
A mathematical model for dynamics of cardiovascular drug action: application to intravenous dihydropyridines in healthy volunteers.
Topics: Adult; Baroreflex; Blood Pressure; Cardiac Output; Cardiovascular Agents; Dihydropyridines; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Male; Models, Theoretical; Nicardipine; Nifedipine; Pressoreceptors; Retrospective Studies; Vascular Resistance | 1993 |
Functional dependence of Ca(2+)-activated K+ current on L- and N-type Ca2+ channels: differences between chicken sympathetic and parasympathetic neurons suggest different regulatory mechanisms.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Separation; Chick Embryo; Dihydropyridines; Ganglia, Parasympathetic; Ganglia, Sympathetic; Ion Channel Gating; Neurons; Nifedipine; omega-Conotoxin GVIA; Peptides; Potassium; Potassium Channels | 1994 |
Acute antihypertensive effects of the new generation calcium antagonist 3-pyridine carboxylic acid 5-[(cyclopropylamino)-carbonyl]-1,4-dihydro-2,6-dimethyl-4-(2-nitrophen yl) octyl ester on conscious spontaneously hypertensive rats and renal hypertensive
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Half-Life; Heart Rate; Hypertension; Hypertension, Renal; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Wistar | 1993 |
[Effect of palonidipine hydrochloride (TC-81), a novel calcium antagonist, on the canine coronary artery].
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Dihydropyridines; Diltiazem; Dogs; In Vitro Techniques; Male; Nifedipine; Potassium; Vasodilator Agents | 1993 |
[Effects of furyl-dihydropyridine on action potential ventricular myocardium of rabbit in vivo and isolated guinea pig left atrium in vitro].
Topics: Acetylcholine; Action Potentials; Animals; Atrial Function; Calcium Channel Blockers; Dihydropyridines; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Microelectrodes; Myocardium; Nifedipine; Rabbits; Sinoatrial Node; Ventricular Function | 1993 |
Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; Carotid Artery, Common; Dihydropyridines; Lactates; Lactic Acid; Male; Nicardipine; Nifedipine; Phosphocreatine; Potassium; Rats; Rats, Wistar; Sodium; Verapamil | 1993 |
[Effect of palonidipine hydrochloride (TC-81), a new dihydropyridine derivative, on various myocardial ischemic models].
Topics: Angina Pectoris; Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Dihydropyridines; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; In Vitro Techniques; Male; Nifedipine; Rats; Rats, Wistar; Vasoconstriction | 1993 |
Calcitonin stimulates calcium transport in distal convoluted tubule cells.
Topics: Animals; Biological Transport; Calcitonin; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cycloheximide; Dihydropyridines; Dose-Response Relationship, Drug; Kidney Tubules, Distal; Membrane Potentials; Mice; Nifedipine; Parathyroid Hormone; Time Factors | 1993 |
The action of amyotrophic lateral sclerosis immunoglobulins on mammalian single skeletal muscle Ca2+ channels.
Topics: Amyotrophic Lateral Sclerosis; Calcium Channels; Dihydropyridines; Humans; Immunoglobulin G; In Vitro Techniques; Muscles; Myasthenia Gravis; Nifedipine | 1993 |
Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition.
Topics: Animals; Blood Pressure; Calcium; Dihydropyridines; Dogs; Guinea Pigs; Ileum; Imidazoles; Male; Molecular Structure; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Nifedipine; Potassium; Pyridines; Rabbits; Rats; Structure-Activity Relationship; Thromboxane-A Synthase | 1993 |
In vitro effects of the new calcium antagonist lacidipine.
Topics: Animals; Aorta; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Papillary Muscles; Potassium | 1993 |
Effects of modulators of cytosolic Ca2+ on phytohemagglutin-dependent Ca2+ response and interleukin-2 production in Jurkat cells.
Topics: Affinity Labels; Azides; Binding Sites; Calcium; Calcium Channel Blockers; Cytosol; Dihydropyridines; Gallic Acid; Glycoproteins; Humans; Interleukin-2; Isradipine; Kinetics; Nifedipine; Phytohemagglutinins; Ryanodine; T-Lymphocytes; Tumor Cells, Cultured | 1993 |
Effects of manidipine and other calcium antagonists on rat renal arcuate arteries.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrobenzenes; Piperazines; Potassium Chloride; Rats; Rats, Wistar; Renal Artery; Serotonin | 1993 |
Ca2+ channel blocking activity of lacidipine and amlodipine in A7r5 vascular smooth muscle cells.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cytosol; Dihydropyridines; Female; Fura-2; Muscle, Smooth, Vascular; Nifedipine; Nitrendipine; Potassium Chloride; Pregnancy; Rats; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1993 |
Endothelin contracts human uterine myometrium by a partly dihydropyridine-sensitive mechanism.
Topics: Dihydropyridines; Diltiazem; Endothelins; Female; Humans; In Vitro Techniques; Middle Aged; Myometrium; Nifedipine; Uterine Contraction | 1993 |
Attenuation of myocardial reperfusion injury by reducing intracellular calcium overloading with dihydropyridines.
Topics: Animals; Calcium; Coronary Circulation; Creatine Kinase; Dihydropyridines; Free Radical Scavengers; Lipid Peroxidation; Male; Myocardial Reperfusion Injury; Myocardium; Nifedipine; Nimodipine; Nisoldipine; Perfusion; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 1993 |
Inhibitory effect of cilnidipine on pressor response to acute cold stress in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Catecholamines; Cold Temperature; Dihydropyridines; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Time Factors | 1995 |
A single non-L-, non-N-type Ca2+ channel in rat insulin-secreting RINm5F cells.
Topics: Animals; Barium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drug Resistance; Insulinoma; Nifedipine; omega-Conotoxin GVIA; Peptides; Rats; Tumor Cells, Cultured | 1996 |
Actions of 1,4-dihydropyridines in isolated mesenteric vascular beds.
Topics: Animals; Arginine; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Nifedipine; Nitrendipine; Nitric Oxide; Nitroarginine; Vasodilation | 1995 |
Heart period variability in patients with variant angina.
Topics: Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Electrocardiography, Ambulatory; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Sympathetic Nervous System | 1996 |
Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Heart Rate; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1996 |
G proteins regulate dihydropyridine binding to moss plasma membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Binding Sites; Bryopsida; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; GTP-Binding Proteins; Guanine Nucleotides; Nifedipine | 1996 |
Regulation of angiotensin II-stimulated Ca2+ oscillations by Ca2+ influx mechanisms in adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium; Calcium Channels; Cattle; Dihydropyridines; Dose-Response Relationship, Drug; Evoked Potentials; Inositol Phosphates; Nifedipine; Terpenes; Thapsigargin; Zona Glomerulosa | 1996 |
[Effect of cilnidipine on renal function in SHR and endothelin-induced renal dysfunction].
Topics: Acute Kidney Injury; Animals; Calcium Channel Blockers; Dihydropyridines; Diuresis; Endothelins; Hypertension; Male; Natriuresis; Nicardipine; Nifedipine; Rats; Rats, Inbred SHR; Renal Circulation | 1996 |
Myocardial and vascular effects of efonidipine in vitro as compared with nifedipine, verapamil and diltiazem.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Wistar; Verapamil | 1996 |
Nitric oxide (EDRF) enhances the vasorelaxing effect of dihydropyridine calcium antagonists in isolated human middle cerebral arteries.
Topics: Adult; Arginine; Calcium Channel Blockers; Cerebral Arteries; Cyclooxygenase Inhibitors; Dihydropyridines; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; In Vitro Techniques; Indomethacin; Isradipine; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Vasodilator Agents | 1996 |
Receptor occupation and pharmacokinetics of MPC-1304, a new Ca2+ channel antagonist, in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Aorta; Binding, Competitive; Calcium Channel Blockers; Cerebral Cortex; Dihydropyridines; Heart; Hypertension; Male; Nifedipine; Rats; Rats, Inbred SHR; Time Factors | 1995 |
Activation of nucleotide receptors inhibits high-threshold calcium currents in NG108-15 neuronal hybrid cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine; Adenylyl Cyclases; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Hybrid Cells; Mice; Mollusk Venoms; Neuroblastoma; Neurons; Nifedipine; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Rats; Receptors, Cell Surface; Virulence Factors, Bordetella | 1996 |
Structural model of a synthetic Ca2+ channel with bound Ca2+ ions and dihydropyridine ligand.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Binding Sites; Biophysical Phenomena; Biophysics; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; In Vitro Techniques; Ion Channel Gating; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nifedipine; Protein Conformation; Protein Structure, Secondary; Thermodynamics | 1996 |
In vitro assessment for vascular selectivity of a new dihydropyridine derivative, NB-818.
Topics: Animals; Blood Vessels; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Female; Femoral Artery; Guinea Pigs; Heart Atria; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Papillary Muscles; Patch-Clamp Techniques; Rabbits | 1996 |
Pharmacological analysis of voltage-dependent potassium currents in cultured skeletal myocytes of the frog Rana temporaria.
Topics: 4-Aminopyridine; Animals; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Electric Conductivity; Embryo, Nonmammalian; Membrane Potentials; Muscle, Skeletal; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rana temporaria; Time Factors; Verapamil | 1995 |
A capacitative calcium current in cultured skeletal muscle cells is mediated by the calcium-specific leak channel and inhibited by dihydropyridine compounds.
Topics: Animals; Calcium Channels; Cells, Cultured; Dihydropyridines; Dimethyl Sulfoxide; Econazole; Enzyme Inhibitors; Genistein; Indoles; Isoflavones; Manganese; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Nifedipine | 1996 |
[Effect of efonidipine hydrochloride on myocardial oxygen balance in anesthetized dogs].
Topics: Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart Rate; Male; Myocardium; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Oxygen Consumption; Thoracotomy | 1996 |
1,4-Dihydropyridines versus beta-blockers for hypertension: are either safe for the heart?
Topics: Adrenergic beta-Antagonists; Adult; Aged; Calcium Channel Blockers; Coronary Disease; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Sympathetic Nervous System | 1996 |
[Effect of efonidipine hydrochloride (NZ-105), a dihydropyridine derivative with calcium antagonistic action, on myocardial oxygen tension in anesthetized dogs].
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Myocardium; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Oxygen Consumption; Partial Pressure | 1996 |
Pharmacological activity of the new calcium antagonist, lacidipine, on isolated preparations.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Female; Heart; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Rabbits; Ventricular Pressure; Verapamil | 1996 |
Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Felodipine; Fumarates; Heart; Iron; Lipid Peroxidation; Male; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Contribution of aranidipine metabolites with slow binding kinetics to the vasodilating activity of aranidipine.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Dogs; Female; Guinea Pigs; Kinetics; Male; Nifedipine; Regional Blood Flow; Vasodilator Agents | 1997 |
Dihydropyridine action on voltage-dependent potassium channels expressed in Xenopus oocytes.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Electric Stimulation; Electrophysiology; Ion Channel Gating; Membrane Potentials; Mice; Nifedipine; Oocytes; Patch-Clamp Techniques; Potassium Channels; Xenopus | 1997 |
L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluorescent Dyes; Isomerism; Isradipine; Kinetics; Nicotinic Acids; Nifedipine; Nitrendipine; Oxadiazoles; Rabbits | 1997 |
Sympathetic modulation of the effect of nifedipine on myocardial contraction and Ca current in the rat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Heart Ventricles; Hypertension; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardial Reperfusion; Nifedipine; Patch-Clamp Techniques; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Sympatholytics; Sympathomimetics; Ventricular Function | 1997 |
Venodilator effects of pranidipine, a 1,4-dihydropyridine Ca2+ channel antagonist, in rats: comparison with nifedipine and amlodipine.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Dihydropyridines; Injections, Intravenous; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Venous Pressure | 1997 |
Depolarization and activation of dihydropyridine-sensitive Ca2+ channels stimulate inositol phosphate accumulation in photoreceptor-enriched chick retinal cell cultures.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Dihydropyridines; Electric Stimulation; Estrenes; Inositol Phosphates; Membrane Potentials; Nifedipine; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Photoreceptor Cells; Potassium; Pyrrolidinones; Type C Phospholipases; Virulence Factors, Bordetella | 1997 |
Inhibitory effects of efonidipine hydrochloride on contraction induced by several vasoconstrictors in porcine coronary artery: comparison with effects of nifedipine and nisoldipine.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding, Competitive; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Endothelin-1; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Potassium; Prostaglandin Endoperoxides, Synthetic; Serotonin; Swine; Thromboxane A2; Vasoconstrictor Agents | 1997 |
Role of dihydropyridine sensitive calcium channels in glucose transport in skeletal muscle.
Topics: Animals; Biological Transport; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Stimulation; Glucose; Insulin; Male; Muscle Contraction; Muscle, Skeletal; Nifedipine; Rats; Rats, Sprague-Dawley | 1997 |
Effect of efonidipine, a novel dihydropyridine derivative, on myocardial metabolic changes induced by coronary artery ligation in dogs: comparison with nifedipine.
Topics: Animals; Calcium Channel Blockers; Carbohydrate Metabolism; Dihydropyridines; Dogs; Energy Metabolism; Female; Hemodynamics; Male; Myocardial Ischemia; Myocardium; Nifedipine; Nitrophenols; Organophosphorus Compounds | 1997 |
Osmo-mechanically sensitive phosphatidylinositol signaling regulates a Ca2+ influx channel in renal epithelial cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carbamates; Cells, Cultured; Dihydropyridines; Enzyme Inhibitors; Epithelium; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Nifedipine; Phenylcarbamates; Phosphatidylinositols; Rabbits; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Water-Electrolyte Balance | 1997 |
Effects of m-nifedipine on dihydropyridine binding sites in hypertrophied left ventricular cell membranes from deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Desoxycorticosterone; Dihydropyridines; Hypertension; Hypertrophy, Left Ventricular; Male; Mitochondria, Heart; Nifedipine; Rats; Rats, Sprague-Dawley | 1996 |
Cardiovascular effects of elgodipine and nifedipine compared in anaesthetized rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Female; Ganglionic Blockers; Heart Rate; Hexamethonium; Myocardial Contraction; Nifedipine; Rats; Rats, Wistar | 1997 |
[Stable angina pectoris: what is the role of calcium antagonists?].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Felodipine; Humans; Metoprolol; Multicenter Studies as Topic; Nifedipine; Randomized Controlled Trials as Topic; Verapamil | 1997 |
Renal effects of the calcium channel blocker aranidipine and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Calcium Channel Blockers; Creatinine; Dihydropyridines; Diuretics; Dogs; Dose-Response Relationship, Drug; Drug Tolerance; Glomerular Filtration Rate; Hemodynamics; Hypertension; Infusions, Intra-Arterial; Kidney; Male; Nifedipine; Organ Size; p-Aminohippuric Acid; Potassium; Rats; Rats, Inbred SHR; Renal Circulation; Sodium; Time Factors; Trichlormethiazide; Urine | 1998 |
Endogenous pacemaker activity of rat tumour somatotrophs.
Topics: Action Potentials; Animals; Antisense Elements (Genetics); Apamin; Barium; Biological Clocks; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Charybdotoxin; Computer Simulation; Cytosol; Dihydropyridines; Growth Hormone; Growth Hormone-Releasing Hormone; Nickel; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Pituitary Neoplasms; Potassium; Rats; Ryanodine Receptor Calcium Release Channel; Sodium; Spider Venoms; Tetraethylammonium; Tetrodotoxin; Tumor Cells, Cultured | 1998 |
Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation.
Topics: Calcium Channel Blockers; Dihydropyridines; Dimyristoylphosphatidylcholine; Lipid Bilayers; Models, Molecular; Molecular Conformation; Molecular Structure; Nifedipine; Phospholipids; Stimulation, Chemical; Thermodynamics | 1998 |
Voltage-gated calcium channels in Pleurodeles oocytes: classification, modulation and functional roles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Breeding; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Dihydropyridines; Electric Stimulation; Ion Channel Gating; Ion Transport; Meiosis; Membrane Potentials; Nickel; Nifedipine; omega-Conotoxin GVIA; Oocytes; Peptides; Phosphorylation; Pleurodeles; Progesterone; Protein Processing, Post-Translational; Seasons; Second Messenger Systems | 1998 |
Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthetics, Inhalation; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Halothane; Heart Ventricles; Isradipine; Myocardial Contraction; Myocardium; Nifedipine; Rats; Rats, Wistar; Sarcolemma; Verapamil | 1998 |
Inhibition of myocardial L- and T-type Ca2+ currents by efonidipine: possible mechanism for its chronotropic effect.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Depression, Chemical; Dihydropyridines; Female; Guinea Pigs; Heart; Heart Rate; Male; Myocardial Contraction; Nifedipine; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques; Potassium Channels; Sinoatrial Node | 1998 |
Effect of cilnidipine, a novel dihydropyridine Ca2+ channel blocker, on adrenal catecholamine secretion in anesthetized dogs.
Topics: Acetylcholine; Adrenal Glands; Animals; Calcium Channel Blockers; Catecholamines; Dihydropyridines; Dimethylphenylpiperazinium Iodide; Dogs; Female; Male; Muscarine; Nifedipine; Nitroprusside | 1998 |
Passive transfer of Lambert-Eaton myasthenic syndrome induces dihydropyridine sensitivity of ICa in mouse motor nerve terminals.
Topics: Animals; Autoantibodies; Binding, Competitive; Calcium; Calcium Channel Blockers; Dihydropyridines; Immunization, Passive; Lambert-Eaton Myasthenic Syndrome; Male; Mice; Mice, Inbred ICR; Motor Neurons; Nifedipine; omega-Agatoxin IVA; omega-Conotoxins; Peptides; Plasma; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spider Venoms; Synaptosomes; Tetraethylammonium; Verapamil | 1998 |
Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts.
Topics: Animals; Benzopyrans; Bradykinin; Cholinesterase Reactivators; Citrulline; Diacetyl; Dihydropyridines; Dose-Response Relationship, Drug; Electrodes; Endothelium, Vascular; Enzyme Inhibitors; Guinea Pigs; Heart; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxygen Consumption; Perfusion; Phosphodiesterase Inhibitors; Pressure; Purinones; Regional Blood Flow; Serotonin; Vasodilator Agents | 1998 |
Selective cardiodepressant activity of fluodipine, a fluorenone-1,4-dihydropyridine derivative.
Topics: Anesthesia; Animals; Aorta; Atrial Function; Binding, Competitive; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Dicarboxylic Acids; Dihydropyridines; Electrophysiology; Female; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Pacemaker, Artificial; Patch-Clamp Techniques; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sinoatrial Node; Vasoconstriction; Vasodilator Agents | 1998 |
New 1,4-dihydropyridines conjugated to furoxanyl moieties, endowed with both nitric oxide-like and calcium channel antagonist vasodilator activities.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Calcium Channel Blockers; Cerebral Cortex; Dihydropyridines; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents | 1998 |
Cytochrome P-450 isoforms involved in carboxylic acid ester cleavage of Hantzsch pyridine ester of pranidipine.
Topics: Biotransformation; Calcium Channel Blockers; Cell Line; Chromatography, High Pressure Liquid; Coenzymes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydropyridines; DNA, Complementary; Enzyme Inhibitors; Humans; Isoenzymes; Microsomes, Liver; Nicotinic Acids; Nifedipine | 1999 |
Sympathoinhibitory effects of central nifedipine in spontaneously hypertensive rats on high versus regular sodium intake.
Topics: Age Factors; Animals; Blood Pressure; Calcium Channel Blockers; Cerebral Ventricles; Dihydropyridines; Heart Rate; Injections, Intravenous; Kidney; Male; Nifedipine; Pharmaceutical Vehicles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Sympathetic Nervous System; Time Factors; Vasodilator Agents | 1999 |
Modulation of neurotransmitter release by dihydropyridine-sensitive calcium channels involves tyrosine phosphorylation.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Adhesion Molecules; Cerebellum; Dihydropyridines; Electrophysiology; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Membrane Potentials; Nerve Tissue Proteins; Nifedipine; omega-Conotoxins; Peptides; Phosphorylation; Potassium; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Time Factors; Tritium; Tyrosine; Vanadates; Vinculin | 1999 |
Effects of morphine in rats withdrawn from repeated nifedipine administration.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Calcium Channel Blockers; Catalepsy; Dihydropyridines; Dopamine; Drug Interactions; In Vitro Techniques; Male; Morphine; Nifedipine; Pain Measurement; Rats; Serotonin; Substance Withdrawal Syndrome; Time Factors | 1999 |
Regional expression and functional characterization of the L-type Ca2+-channel in myocardium from patients with end-stage heart failure and in non-failing human hearts.
Topics: Adolescent; Adult; Aged; Binding Sites; Blotting, Northern; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calsequestrin; Cardiomyopathy, Dilated; Dihydropyridines; Dose-Response Relationship, Drug; Female; Heart; Heart Failure; Humans; Male; Middle Aged; Myocardium; Nifedipine; Tissue Distribution | 1999 |
L-type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cholinergic Fibers; Dihydropyridines; Excitatory Amino Acid Agonists; Magnesium; Motor Neurons; Muscarine; Muscarinic Agonists; N-Methylaspartate; Nicotinic Antagonists; Nifedipine; Organ Culture Techniques; Periodicity; Receptors, N-Methyl-D-Aspartate; Serotonin; Spinal Cord; Tetrodotoxin; Tubocurarine; Turtles | 1999 |
Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylic acid methyl 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (CV-159), on rat ischemic brain injury.
Topics: Animals; Body Temperature; Brain Edema; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cerebral Infarction; Dihydropyridines; Hemodynamics; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Neuroprotective Agents; Nicardipine; Nifedipine; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Water | 1999 |
Gingival hyperplasia due to calcium antagonists.
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Gingival Hyperplasia; Humans; Nifedipine; Verapamil | 1998 |
Effects of long-acting versus short-acting calcium channel blockers among older survivors of acute myocardial infarction.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Humans; Male; Myocardial Infarction; Nicardipine; Nifedipine; Proportional Hazards Models; Retrospective Studies; Risk; Survival Analysis; Survivors; Verapamil | 1999 |
Sustained-release nifedipine: new indication. Angina: safer drugs are available.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angina, Unstable; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Diltiazem; Drug Evaluation; Female; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Nifedipine; Randomized Controlled Trials as Topic; Treatment Outcome; Vasodilator Agents | 1998 |
Effects of L-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats.
Topics: Animals; Calcium Channel Blockers; Conditioning, Operant; Dihydropyridines; Discrimination Learning; Ethanol; Feeding Behavior; Isradipine; Male; Nifedipine; Rats; Taste | 1999 |
Effects of some 1,4-dihydropyridine Ca antagonists on the blast transformation of rat spleen lymphocytes.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Lymphocyte Activation; Nicardipine; Nifedipine; Nimodipine; Rats; Spleen | 1999 |
Vasodilating effect of benidipine hydrochloride in the renal and hindquarter vascular regions (supplied by terminal aorta) of spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Dihydropyridines; Heart Rate; Hindlimb; Injections, Intravenous; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Wistar; Regional Blood Flow; Renal Circulation; Vascular Resistance; Vasodilator Agents | 1999 |
In vivo receptor occupancy and plasma concentration of pranidipine, a potent and long-acting dihydropyridine calcium antagonist.
Topics: Algorithms; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Isradipine; Male; Myocardium; Nifedipine; Rats; Rats, Inbred SHR | 1999 |
[Effects of benidipine hydrochloride (Coniel) on blood pressure, heart rate and plasma norepinephrine concentration in spontaneously hypertensive rats].
Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Heart Rate; Hypertension; Male; Nifedipine; Norepinephrine; Rats; Rats, Inbred SHR | 1999 |
Volume regulatory decrease in UMR-106.01 cells is mediated by specific alpha1 subunits of L-type calcium channels.
Topics: Animals; Bone Neoplasms; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Size; Dihydropyridines; Hypotonic Solutions; Nifedipine; Oligonucleotides, Antisense; Osmolar Concentration; Osteoblasts; Osteosarcoma; Patch-Clamp Techniques; Protein Isoforms; Rats; Tumor Cells, Cultured | 1999 |
Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Coronary Circulation; Dihydropyridines; Heart Atria; Heart Block; Heart Rate; Isradipine; Male; Myocardial Contraction; Nifedipine; Pyridines; Rats; Rats, Sprague-Dawley; Systole; Ventricular Function, Left; Ventricular Pressure | 1999 |
Effects of the antihypertensive drug nifedipine on albuminuria and renal histopathology in young spontaneously hypertensive rats with diabetes.
Topics: Albuminuria; Animals; Antihypertensive Agents; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dihydropyridines; Kidney; Male; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred SHR; Time Factors; Vasodilator Agents | 1999 |
Calcium channel activation and self-biting in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aggression; Animals; Behavior, Animal; Bites and Stings; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Diltiazem; Ion Channel Gating; Mice; Mice, Inbred C57BL; Nifedipine; Nimodipine; Nitrendipine; Pyrroles; Self-Injurious Behavior | 1999 |
Pranidipine enhances the action of nitric oxide released from endothelial cells.
Topics: Amlodipine; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cells, Cultured; Coculture Techniques; Cyclic GMP; Dihydropyridines; Endothelin-1; Endothelium, Vascular; Humans; Hypertension; Male; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Superoxide Dismutase | 2000 |
Effect of benidipine on depolarizing stimulation-induced increase of intracellular calcium concentration in cultured mouse hippocampal neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Electric Stimulation; Hippocampus; Mice; Neurons; Nicardipine; Nifedipine | 1999 |
Calcium channels functional roles in the frog semicircular canal.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dose-Response Relationship, Drug; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Neurons, Afferent; Nifedipine; Nimodipine; omega-Agatoxin IVA; omega-Conotoxins; Physical Stimulation; Rana esculenta; Semicircular Canals | 2000 |
Arterial responses in vitro and plasma digoxin immunoreactivity after losartan and enalapril treatments in experimental hypertension.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Digoxin; Dihydropyridines; Enalapril; Heart; Hypertension; Losartan; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Organ Size; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium-Potassium-Exchanging ATPase; Tunica Media | 2000 |
Is there any difference between intermediate-acting and long-acting calcium antagonists in diurnal blood pressure and autonomic nervous activity in hypertensive coronary artery disease patients?
Topics: Autonomic Nervous System; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Coronary Disease; Delayed-Action Preparations; Dihydropyridines; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Treatment Outcome | 2000 |
Effect of calcium channel blockers, nifedipine and benidipine, on death of cultured mouse mesangi al cells.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cycloheximide; Dihydropyridines; Glomerular Mesangium; L-Lactate Dehydrogenase; Mice; Nifedipine; Protein Synthesis Inhibitors; Tumor Necrosis Factor-alpha | 2000 |
Calcium channel blockers inhibit proliferation and matrix production in rat mesangial cells: possible mechanism of suppression of AP-1 and CREB activities.
Topics: Animals; Antibodies; Blotting, Northern; Calcium Channel Blockers; Cell Division; Cells, Cultured; Collagen; Cyclic AMP Response Element-Binding Protein; Dihydropyridines; Electrophoresis; Extracellular Matrix; Fibronectins; Gene Expression; Glomerular Mesangium; Nifedipine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Thymidine; Transcription Factor AP-1; Transforming Growth Factor beta; Tritium | 2000 |
Characterization of calcium-mobilizing, purinergic P2Y(2) receptors in human ovarian cancer cells.
Topics: Adenosine Triphosphate; Calcium; Calcium Channel Blockers; Cell Division; Dihydropyridines; Enzyme Activation; Enzyme Inhibitors; Female; Glycerophospholipids; Humans; Nifedipine; Ovarian Neoplasms; Phospholipase D; Potassium; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Thapsigargin; Tumor Cells, Cultured; Uridine Triphosphate | 2000 |
Dihydropyridine-induced Ca2+ release from ryanodine-sensitive Ca2+ pools in human skeletal muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Humans; Muscle, Skeletal; Nifedipine; Nitrendipine; PC12 Cells; Protein Conformation; Rats; Ryanodine; Ryanodine Receptor Calcium Release Channel | 2000 |
Mibefradil, an I(Ca,T) blocker, effectively blocks I(Ca,L) in rabbit sinus node cells.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Female; Mibefradil; Nifedipine; Rabbits; Sinoatrial Node | 2000 |
Possible involvement of endothelin-1 in cardioprotective effects of benidipine.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Cardiomegaly; Cells, Cultured; Dihydropyridines; Endothelin-1; Hypertension; Leucine; Muscle Fibers, Skeletal; Myocardium; Nifedipine; Rats; Rats, Wistar; Thymidine; Tritium | 2000 |
The effects of calcium channel blockers on nuclear factor kappa B activation in the mesangium cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcimycin; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Carcinogens; Cells, Cultured; Dihydropyridines; Gene Expression; Genes, Reporter; Glomerular Mesangium; Humans; Ionophores; Luciferases; NF-kappa B; Nifedipine; Nitrophenols; Organophosphorus Compounds; Tetradecanoylphorbol Acetate; Verapamil | 2000 |
Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Culture Techniques; Dihydropyridines; Electrophysiology; Ion Channel Gating; Kinetics; Mice; Muscle, Skeletal; Nifedipine; Ryanodine Receptor Calcium Release Channel; Time Factors | 2000 |
Venodilatory effect of pranidipine, a calcium channel blocker, monitored with perfluorocarbon in vivo (19)F-NMR spectroscopy.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Fluorine; Fluorocarbons; Hemodynamics; Laser-Doppler Flowmetry; Magnetic Resonance Spectroscopy; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilator Agents; Veins | 2000 |
Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons.
Topics: Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cerebellum; Cyclic AMP Response Element-Binding Protein; Dihydropyridines; Genes, Dominant; Mice; Models, Biological; Mutation; Neurons; Neuroprotective Agents; Nifedipine; Phosphorylation; Potassium; Protein Processing, Post-Translational | 2001 |
Gadolinium prevents stretch-mediated contractile dysfunction in isolated papillary muscles.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Gadolinium; Guinea Pigs; Heart Failure; Hypoxia; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Nifedipine; Oxygen; Papillary Muscles | 2001 |
Activation of purified cardiac ryanodine receptors by dihydropyridine agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Dogs; Membrane Potentials; Myocardium; Nicotinic Acids; Nifedipine; Oxadiazoles; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Stereoisomerism | 2001 |
Chronic nicotine alters NO signaling of Ca(2+) channels in cerebral arterioles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arterioles; Barium; Calcium; Calcium Channels; Calcium Channels, L-Type; Cerebral Arteries; Cerebrovascular Circulation; Cyclic GMP; Dihydropyridines; Electric Stimulation; Female; Membrane Potentials; Muscle, Smooth, Vascular; Nicotine; Nifedipine; Nitric Oxide; Nitroprusside; Potassium Channels; Rats; Rats, Inbred WKY; Signal Transduction; Time Factors; Tyrphostins | 2001 |
Normal-phase TLC separation of enantiomers of 1.4-dihydropyridine derivatives.
Topics: Calcium Channel Blockers; Chromatography, Thin Layer; Dihydropyridines; Felodipine; Methanol; Nifedipine; Solvents; Stereoisomerism | 2001 |
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Cytosol; Dihydropyridines; Diltiazem; Egtazic Acid; Gadolinium; Hydrogen Peroxide; Isradipine; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Lanthanum; Nifedipine; Protamines; Rats; Rats, Sprague-Dawley; Thapsigargin; Verapamil | 2001 |
Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits.
Topics: Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Ciliary Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Endothelin-1; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Nifedipine; Optic Disk; Piperazines; Rabbits; Regional Blood Flow | 2001 |
Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Chloride Channels; Dihydropyridines; Drug Interactions; Glycine; Neural Inhibition; Neurons; Nicardipine; Nifedipine; Nitrendipine; Rats; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Synaptic Transmission; Verapamil | 2001 |
Effects of the L- and N-type calcium channel blocker cilnidipine on growth of vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Animals; Calcium Channel Blockers; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Dihydropyridines; DNA; Fibroblast Growth Factor 2; Muscle, Smooth, Vascular; Nifedipine; Platelet-Derived Growth Factor; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Semipersonalized psychological evaluation of quality of life in hypertensive patients during a trial with two calcium antagonists: a multicenter Latin-American Study (LASTLHY).
Topics: Activities of Daily Living; Administration, Oral; Adult; Aged; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Exercise; Female; Health Surveys; Humans; Hypertension; Male; Middle Aged; Nifedipine; Psychometrics; Quality of Life | 2001 |
Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; Calcium Channels; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Hepatocytes; Humans; Kinetics; Mixed Function Oxygenases; Nifedipine; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Time Factors | 2001 |
Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Male; Mibefradil; Natriuresis; Nifedipine; Nitric Oxide; Nitrophenols; Organophosphorus Compounds; Prostaglandins; Renal Circulation | 2001 |
Dihydropyridine calcium channel blockers and peripheral side effects.
Topics: Calcium Channel Blockers; Dihydropyridines; Edema; Erythema; Exanthema; Humans; Hyperpigmentation; Hypertension; Male; Middle Aged; Nifedipine | 2001 |
Divergent renal vasodilator action of L- and T-type calcium antagonists in vivo.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Dogs; Hemodynamics; Mibefradil; Microcirculation; Nifedipine; Nitrophenols; Organophosphorus Compounds; Renal Circulation; Vasodilation | 2001 |
U-46619-induced potentiation of noradrenergic constriction in the human saphenous vein: antagonism by thromboxane receptor blockade.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Male; Middle Aged; Nifedipine; Norepinephrine; Potassium Chloride; Receptors, Thromboxane; Saphenous Vein; Stimulation, Chemical; Thromboxane A2; Vasoconstrictor Agents | 2001 |
In vivo measurement of 1,4-dihydropyridine receptors in mesenteric arteries of spontaneously hypertensive rats and effect of nifedipine and cilnidipine.
Topics: Animals; Area Under Curve; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Dose-Response Relationship, Drug; Injections, Intravenous; Isradipine; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Inbred SHR; Tissue Distribution | 2002 |
Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 6-Ketoprostaglandin F1 alpha; Anesthesia; Animals; Aorta; Blood Pressure; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cardiac Output; Consciousness; Dihydropyridines; Female; Heart Rate; Muscle, Smooth, Vascular; Nifedipine; Pregnancy; Pregnancy, Animal; Rabbits; Thromboxane B2; Tritium | 2002 |
Synthesis and calcium channel antagonist activity of nifedipine analogues with methylthioimidazole substituent.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Spectrophotometry, Infrared; Structure-Activity Relationship | 2002 |
In vivo receptor binding of benidipine and amlodipine in mesenteric arteries and other tissues of spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Area Under Curve; Blood Proteins; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Dihydropyridines; Drug Interactions; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocardium; Nifedipine; Protein Binding; Rats; Rats, Inbred SHR; Tissue Distribution | 2002 |
Dihydropyridines are not substitutable without careful monitoring.
Topics: Adverse Drug Reaction Reporting Systems; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Delayed-Action Preparations; Dihydropyridines; Felodipine; Humans; Nifedipine | 2002 |
Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains.
Topics: Ampicillin; Anti-Bacterial Agents; Dihydropyridines; Drug Interactions; Drug Resistance, Bacterial; Erythromycin; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Nifedipine | 2002 |
[Pharmaceutical chemistry of "dipines"].
Topics: Amlodipine; Calcium Channel Blockers; Dihydropyridines; Molecular Structure; Nifedipine; Nimodipine; Structure-Activity Relationship | 2002 |
NTP, the photoproduct of nifedipine, activates caffeine-sensitive ion channels in leech neurons.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Membrane; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Ganglia, Invertebrate; Intracellular Fluid; Ion Channels; Leeches; Membrane Potentials; Neurons; Nifedipine | 2003 |
Antioxidant activity of different dihydropyridines.
Topics: Amlodipine; Animals; Antioxidants; Cattle; Cells, Cultured; Dihydropyridines; Endothelium, Vascular; Fluoresceins; Humans; Lipoproteins, LDL; Molecular Structure; Nifedipine; Nimodipine; Reactive Oxygen Species | 2003 |
Cilnidipine as an agent to lower blood pressure without sympathetic nervous activation as demonstrated by iodine-123 metaiodobenzylguanidine imaging in rat hearts.
Topics: 3-Iodobenzylguanidine; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Heart; Heart Conduction System; Heart Rate; Male; Nifedipine; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Sympathetic Nervous System | 2003 |
Protective effect of benidipine against sodium azide-induced cell death in cultured neonatal rat cardiac myocytes.
Topics: Adenosine Triphosphate; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Captopril; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dihydropyridines; Dipeptides; Dose-Response Relationship, Drug; In Vitro Techniques; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria, Muscle; Myocytes, Cardiac; Nifedipine; Rats; Rats, Sprague-Dawley; Sodium Azide; Tetrazoles | 2003 |
Negative inotropic drugs alter indexes of cytosolic [Ca(2+)]-left ventricular pressure relationships after ischemia.
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cytosol; Diacetyl; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Lidocaine; Myocardial Ischemia; Myocardial Reperfusion Injury; Nifedipine; Osmolar Concentration; Pressure; Ventricular Function, Left | 2004 |
Decoration of dihydropyrimidine and dihydropyridine scaffolds with sugars via Biginelli and Hantzsch multicomponent reactions: an efficient entry to a collection of artificial nucleosides.
Topics: Carbohydrates; Dihydropyridines; Glycosylation; Nifedipine; Nucleosides; Pyrimidines; Stereoisomerism; Thiones | 2003 |
MRS study of the interaction of dihydropyridines with lipid molecules in phosphatidylcholine vesicles.
Topics: Dihydropyridines; Dimyristoylphosphatidylcholine; Lipid Metabolism; Lipids; Liposomes; Magnetic Resonance Spectroscopy; Molecular Structure; Nifedipine | 2003 |
Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Cerebral Infarction; Dihydropyridines; Dose-Response Relationship, Drug; Male; Nifedipine; Rats; Rats, Sprague-Dawley | 2004 |
[Bisbenzothieno[3,2-b: 2',3'-e]pyridines].
Topics: Acetates; Decarboxylation; Dihydropyridines; Indicators and Reagents; Magnetic Resonance Spectroscopy; Nifedipine; Oxidants; Pyridines; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiophenes | 2004 |
Different effects of L-type and L+N-type calcium channel blockers on hamster cheek pouch venules.
Topics: Animals; Arterioles; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Cricetinae; Dihydropyridines; Male; Mesocricetus; Mouth Mucosa; Nifedipine; omega-Conotoxins; Regional Blood Flow; Venules | 2004 |
Case studies in hypertension. Dihydropyridine/nondihydropyridine calcium channel blocker combination therapy.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Female; Humans; Hypertension; Lisinopril; Male; Middle Aged; Nifedipine; Verapamil | 2005 |
Emergence of a R-type Ca2+ channel (CaV 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage.
Topics: Animals; Blood; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, R-Type; Cerebral Arteries; Cisterna Magna; Dihydropyridines; Diltiazem; Disease Models, Animal; Drug Resistance; Injections; Ion Transport; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Rabbits; Spider Venoms; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial | 2005 |
1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Female; Flavones; Guinea Pigs; Heart Atria; Nifedipine; Vasodilator Agents | 2005 |
Potential therapeutic implication of nifedipine, a dihydropyridine-based calcium antagonist, in advanced glycation end product (AGE)-related disorders.
Topics: Calcium; Calcium Channel Blockers; Dihydropyridines; Disease Progression; Glycation End Products, Advanced; Humans; Inflammation; Models, Biological; Models, Theoretical; Nifedipine; Oxidative Stress; Signal Transduction | 2005 |
Increased vascular selectivity and prolonged pharmacological efficacy of the L-type Ca2+ channel antagonist lercanidipine in human cardiovascular tissue.
Topics: Adolescent; Adult; Aged; Amlodipine; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Female; Humans; In Vitro Techniques; Male; Mammary Arteries; Middle Aged; Myocardial Contraction; Nifedipine; Protein Binding; Stimulation, Chemical; Vasodilation | 2005 |
Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i.
Topics: Animals; Calcium; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Endothelium, Vascular; Nifedipine; Nitric Oxide; Swine; Vasodilation | 2006 |
The L-type calcium channel blockers, hantzsch 1,4-dihydropyridines, are not peroxyl radical-trapping, chain-breaking antioxidants.
Topics: Acridines; Antioxidants; Benzene Derivatives; Biphenyl Compounds; Calcium Channel Blockers; Calcium Channels, L-Type; Chromans; Dihydropyridines; Free Radicals; Hydrazines; Kinetics; Nifedipine; Nimodipine; Oxidation-Reduction; Peroxides; Picrates; Styrene | 2006 |
Design, synthesis, and calcium channel antagonist activity of new 1,4-dihydropyridines containing 4-(5)-chloro-2-ethyl-5-(4)-imidazolyl substituent.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drug Design; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Male; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Nifedipine; Structure-Activity Relationship | 2006 |
The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azides; Calcium Channel Blockers; Cell Line; Chlorophyll; Dihydropyridines; Drug Interactions; Humans; Mitoxantrone; Neoplasm Proteins; Nicardipine; Nifedipine; Photoaffinity Labels; Prazosin | 2006 |
Limited plasticity of mesenchymal stem cells cocultured with adult cardiomyocytes.
Topics: Actinin; Animals; Animals, Genetically Modified; Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Differentiation; Cells, Cultured; Coculture Techniques; Connexin 43; Dihydropyridines; Fluorescent Dyes; Green Fluorescent Proteins; Ion Channel Gating; Mesenchymal Stem Cells; Myocytes, Cardiac; Myosins; Nifedipine; Rats; Sarcomeres | 2007 |
Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms.
Topics: Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Humans; Mibefradil; Nifedipine; Nitrophenols; Organophosphorus Compounds; Recombinant Proteins | 2006 |
Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species.
Topics: Aorta; Azetidinecarboxylic Acid; Biphenyl Compounds; Calcium Channel Blockers; Cell Adhesion; Cell Membrane; Cyclic N-Oxides; Dihydropyridines; Dose-Response Relationship, Drug; Endothelial Cells; Fluoresceins; Free Radical Scavengers; Gene Expression Regulation; Humans; Hydrazines; Indicators and Reagents; Inflammation; Ketocholesterols; Monocytes; NF-kappa B p50 Subunit; Nifedipine; Picrates; Protein Transport; Reactive Oxygen Species; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha; U937 Cells; Vascular Cell Adhesion Molecule-1 | 2006 |
The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.
Topics: Calcium Channel Blockers; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Gamma Rays; Humans; Hypertension; Models, Molecular; Molecular Conformation; Myocardial Ischemia; Nifedipine; Nimodipine | 2007 |
Vasodilator effects of bis-dihydropyridines structurally related to nifedipine.
Topics: Animals; Aorta; Calcium; Dihydropyridines; Male; Molecular Structure; Nifedipine; Potassium; Rats; Rats, Wistar; Vasodilator Agents | 2006 |
Prevention of diabetic vascular calcification by nifedipine, a dihydropyridine-based calcium channel blocker.
Topics: Calcinosis; Calcium Channel Blockers; Diabetes Mellitus; Dihydropyridines; Humans; Models, Biological; Nifedipine | 2007 |
Effects of benidipine in a rat model for experimental angina.
Topics: Amlodipine; Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Male; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred Strains | 2006 |
Azelnidipine inhibits H2O2-induced cell death in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Azetidinecarboxylic Acid; Blotting, Western; Calcium Channel Blockers; Cell Death; Cell Survival; Cells, Cultured; Dihydropyridines; Extracellular Signal-Regulated MAP Kinases; Hydrogen Peroxide; MAP Kinase Kinase 4; Myocytes, Cardiac; Nifedipine; p38 Mitogen-Activated Protein Kinases; Rats | 2007 |
3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart.
Topics: Animals; Antineoplastic Agents; Arrhythmias, Cardiac; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Electrocardiography; Heart; Heart Conduction System; In Vitro Techniques; Male; Nifedipine; Perfusion; Rats; Rats, Sprague-Dawley; Ventricular Function, Left; Ventricular Pressure | 2007 |
Cardiac effects of L/N-type Ca2+ channel blocker cilnidipine in anesthetized dogs.
Topics: Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Dihydropyridines; Dogs; Female; Heart; Heart Rate; Male; Nifedipine; Sympatholytics | 2007 |
A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine.
Topics: Alternative Splicing; Animals; Biophysics; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Electrophysiology; Exons; Humans; Male; Models, Biological; Muscle, Smooth; Myocardium; Nifedipine; Protein Isoforms; Rats; Rats, Wistar | 2007 |
Effects of benidipine and some other calcium channel blockers on the prognosis of patients with vasospastic angina. Cohort study with evaluation of the ergonovine coronary spasm induction test.
Topics: Adult; Aged; Aging; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Cohort Studies; Coronary Angiography; Coronary Stenosis; Coronary Vasospasm; Diabetes Complications; Dihydropyridines; Diltiazem; Ergonovine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifedipine; Oxytocics; Prognosis; Risk Factors | 2007 |
Ultra-performance liquid chromatography-tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic study.
Topics: Acetates; Administration, Oral; Buffers; Calcium Channel Blockers; Calibration; Chromatography, Liquid; Clinical Trials as Topic; Dihydropyridines; Drug Stability; Freezing; Humans; Hydrogen-Ion Concentration; Male; Methyl Ethers; Molecular Structure; Nifedipine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry | 2008 |
Prognostic effects of calcium channel blockers on cardiac events, stroke and end-stage renal disease in patients with angina pectoris. Retrospective comparative study of benidipine, diltiazem and nifedipine.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Heart Diseases; Humans; Kidney Failure, Chronic; Male; Nifedipine; Prognosis; Proportional Hazards Models; Retrospective Studies; Stroke; Treatment Outcome | 2008 |
Prevention of vascular injury by combination of an AT1 receptor blocker, olmesartan, with various calcium antagonists.
Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Azetidinecarboxylic Acid; Calcium Channel Blockers; Chemokine CCL2; Dihydropyridines; Drug Synergism; Femoral Artery; Imidazoles; Ligation; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Neuropeptides; Nifedipine; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Superoxides; Tetrazoles; Tumor Necrosis Factor-alpha; Tunica Intima | 2009 |
Vasodilatory effect of cilnidipine, an L-type and N-type calcium channel blocker, on rat kidney glomerular arterioles.
Topics: Animals; Arterioles; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Female; Hydronephrosis; Kidney Glomerulus; Nifedipine; omega-Conotoxins; Rats; Rats, Inbred SHR; Vasodilator Agents | 2008 |
Synthesis, evaluation of pharmacological activities and quantitative structure-activity relationship studies of a novel group of bis(4-nitroaryl-1,4-dihyropyridine).
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Inhibitory Concentration 50; Male; Models, Molecular; Muscle, Smooth; Nifedipine; Quantitative Structure-Activity Relationship | 2009 |
Heterogeneity of L- and T-channels in the vasculature: rationale for the efficacy of combined L- and T-blockade.
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Humans; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Mibefradil; Microvessels; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Sprague-Dawley; Subcutaneous Fat; Vasoconstriction; Verapamil | 2009 |
Is combined L- and T-channel blockade better than L-channel blockade in therapy?
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Drug Synergism; Humans; Hypertension; Mesenteric Arteries; Mibefradil; Microvessels; Nifedipine; Nitrophenols; Rats; Vasoconstriction; Verapamil | 2009 |
Azelnidipine exerts renoprotective effects by improvement of renal microcirculation in angiotensin II infusion rats.
Topics: Angiotensin II; Animals; Azetidinecarboxylic Acid; Calcium Channel Blockers; Dihydropyridines; Infusions, Intravenous; Male; Microcirculation; Nephritis, Interstitial; Nifedipine; Rats; Rats, Wistar; Renal Circulation | 2009 |
Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker.
Topics: Administration, Oral; Amines; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cyclohexanecarboxylic Acids; Dihydropyridines; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Models, Animal; Nifedipine; omega-Conotoxins; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2009 |
Effects of combination therapy with angiotensin II type I receptor blockers and calcium channel blockers on renal function in hypertensive patients/a retrospective, "real-world" comparative study.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Creatinine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hypertension; Kaplan-Meier Estimate; Kidney; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Nifedipine; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Treatment Outcome | 2010 |
Flutamide inhibits nifedipine- and interleukin-1 beta-induced collagen overproduction in gingival fibroblasts.
Topics: Androgen Antagonists; Calcium Channel Blockers; Case-Control Studies; Cell Culture Techniques; Cells, Cultured; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Connective Tissue Growth Factor; Culture Media, Conditioned; Dihydropyridines; Drug Synergism; Female; Fibroblasts; Flutamide; Gingiva; Gingival Overgrowth; Humans; Interleukin-1beta; Male; Middle Aged; Nifedipine; Receptors, Androgen; Time Factors | 2010 |
Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dicarboxylic Acids; Dihydropyridines; Humans; Inhibitory Concentration 50; Molecular Structure; Nifedipine | 2010 |
[Antihypertrophic effect of dihydropyridines calcium channel blockers is dependent on their potential of blocking N-type calcium channel].
Topics: Amlodipine; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cardiomegaly; Dihydropyridines; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Nifedipine | 2010 |
Facile and efficient aromatization of 1,4-dihydropyridines with M(NO3)2.XH2O, TNCB, TBAP and HMTAI and preparation of deuterium labeled dehydronifedipine from nifedipine-d3.
Topics: Calcium Channel Blockers; Deuterium; Dihydropyridines; Humans; Metals; Methenamine; Nifedipine; Nitrates; Quaternary Ammonium Compounds; Radiopharmaceuticals; Vasodilator Agents | 2010 |
Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase.
Topics: Aged; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Cyclic GMP; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; In Vitro Techniques; Male; Mammary Arteries; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2011 |
Comparative study on antioxidant effects and vascular matrix metalloproteinase-2 downregulation by dihydropyridines in renovascular hypertension.
Topics: Amlodipine; Animals; Antioxidants; Aorta, Thoracic; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Down-Regulation; Gelatinases; Hypertension, Renovascular; Hypertrophy; Lipid Peroxides; Male; Matrix Metalloproteinase 2; Nifedipine; Nimodipine; Rats; Rats, Wistar; Reactive Oxygen Species; Tunica Media | 2011 |
Inhibitory effects of T/L-type calcium channel blockers on tubulointerstitial fibrosis in obstructed kidneys in rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Fibrosis; Kidney Tubules; Male; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Ureteral Obstruction | 2011 |
Calcium inhibits dihydropyridine-stimulated increases in opening and unitary conductance of a plant Ca²+ channel.
Topics: Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Lipid Bilayers; Membrane Potentials; Membranes, Artificial; Nicotinic Acids; Nifedipine; Oxadiazoles; Plant Roots; Triticum | 2011 |
New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cations; Cell Line; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Kidney; Membrane Potentials; Nifedipine | 2011 |
Investigation of the effects of α1-adrenoceptor antagonism and L-type calcium channel blockade on ejaculation and vas deferens and seminal vesicle contractility in vitro.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Dose-Response Relationship, Drug; Ejaculation; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Seminal Vesicles; Sulfonamides; Tamsulosin; Vas Deferens | 2012 |
Synthesis and biological evaluation of some novel 1,4-dihydropyridines as potential antitubercular agents.
Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Dihydropyridines; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nifedipine; Structure-Activity Relationship; Vero Cells | 2011 |
Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Fibroblasts; Fibrosis; Myocardium; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Smad2 Protein; Transfection; Transforming Growth Factor beta1 | 2011 |
Clinical case: Peritoneal dialysis patient with cloudy peritoneal fluid following administration of calcium antagonists.
Topics: Adult; Antihypertensive Agents; Ascitic Fluid; Calcium Channel Blockers; Cardiovascular Agents; Chylous Ascites; Diagnosis, Differential; Dihydropyridines; Drug Therapy, Combination; Female; Glomerulonephritis, Membranoproliferative; Humans; Kidney Failure, Chronic; Nifedipine; Nitrobenzenes; Peritoneal Dialysis, Continuous Ambulatory; Peritonitis; Piperazines; Retrospective Studies; Triglycerides | 2011 |
Design and synthesis of new 1,4-dihydropyridines containing 4(5)-chloro-5(4)-imidazolyl substituent as a novel calcium channel blocker.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Drug Design; Guinea Pigs; Hydrogen Bonding; Ileum; Imidazoles; In Vitro Techniques; Male; Models, Molecular; Molecular Structure; Muscle Contraction; Muscle, Smooth; Nifedipine; Quantitative Structure-Activity Relationship | 2011 |
L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Dihydropyridines; Disease Models, Animal; Down-Regulation; Hypertension; Injections, Intravenous; Male; Nifedipine; Rats; Rats, Inbred SHR; Reflex; Renin-Angiotensin System | 2012 |
T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.
Topics: Animals; Azoles; Base Sequence; beta-Thalassemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiovascular System; Deferoxamine; Dihydropyridines; Disease Models, Animal; DNA Primers; Heart Rate; Humans; Iron; Iron Chelating Agents; Iron, Dietary; Isoindoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Nifedipine; Nitrophenols; Organ Size; Organophosphorus Compounds; Organoselenium Compounds; RNA, Messenger; Ventricular Function, Left; Verapamil | 2012 |
Selective inhibitory action of Biginelli-type dihydropyrimidines on depolarization-induced arterial smooth muscle contraction.
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction; Vasoconstrictor Agents | 2012 |
How do dihydropyridine and nondihydropyridine CCBs differ?
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Heart Conduction System; Humans; Nifedipine | 2012 |
Nitric oxide inhibits androgen receptor-mediated collagen production in human gingival fibroblasts.
Topics: Aged; Case-Control Studies; Cells, Cultured; Collagen Type I; Dihydropyridines; Fibroblasts; Gingiva; Gingival Overgrowth; Humans; Interleukin-1beta; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase Type II; Receptors, Androgen; Statistics, Nonparametric | 2012 |
Anti-arrhythmic and hemodynamic effects of oxy nifedipine, oxy nimodipine, oxy nitrendipine and oxy nisoldipine.
Topics: Administration, Intravenous; Administration, Oral; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Dihydropyridines; Heart; Hemodynamics; Male; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2012 |
Benidipine persistently inhibits delayed rectifier K(+)-channel currents in murine thymocytes.
Topics: Animals; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Kv1.3 Potassium Channel; Male; Membrane Potentials; Mice; Nifedipine; Thymocytes | 2013 |
Effect of antihypertensive treatments on insulin signalling in lympho-monocytes of essential hypertensive patients: a pilot study.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Drug Combinations; Enalapril; Essential Hypertension; Female; Glucose Transporter Type 4; Humans; Hypertension; Insulin; Lymphocytes; Male; Middle Aged; Monocytes; Nifedipine; Pilot Projects; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Acute effects of intravenous nifedipine or azelnidipine on open-loop baroreflex static characteristics in rats.
Topics: Administration, Intravenous; Animals; Azetidinecarboxylic Acid; Baroreflex; Blood Pressure; Calcium Channel Blockers; Carotid Sinus; Dihydropyridines; Male; Nifedipine; Pressoreceptors; Rats; Rats, Inbred WKY | 2015 |
Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion.
Topics: Action Potentials; Adrenocorticotropic Hormone; Angiotensin II; Animals; Benzamides; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cattle; Cyclic AMP; Dihydropyridines; Fluspirilene; Gene Expression; Hydrocortisone; Microelectrodes; Nifedipine; Patch-Clamp Techniques; Penfluridol; Pimozide; Piperidines; Protein Isoforms; Single-Cell Analysis; Zona Fasciculata | 2015 |
Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion.
Topics: Acetaminophen; Benzimidazoles; Benzoates; Biphenyl Compounds; Chromatography, High Pressure Liquid; Clomipramine; Dihydropyridines; Enkephalin, Leucine; Humans; Mass Spectrometry; Nifedipine; Pharmaceutical Preparations; Simvastatin; Telmisartan; Tetrazoles; Time Factors | 2015 |
Repetition priming-induced changes in sensorimotor transmission.
Topics: Action Potentials; Animals; Aplysia; Calcium; Calcium Channel Blockers; Dihydropyridines; Ganglia, Invertebrate; Long-Term Potentiation; Motor Neurons; Neurons, Afferent; Neuropeptides; Nifedipine; Repetition Priming; Synaptic Transmission | 2016 |
Comparison of direct effects of clinically available vasodilators; nitroglycerin, nifedipine, cilnidipine and diltiazem, on human skeletonized internal mammary harvested with ultrasonic scalpel.
Topics: Coronary Artery Bypass; Dihydropyridines; Diltiazem; Humans; In Vitro Techniques; Mammary Arteries; Nifedipine; Nitroglycerin; Vasoconstriction; Vasodilator Agents | 2016 |
Synthesis, Evaluation of Pharmacological Activity, and Molecular Docking of 1,4-Dihydropyridines as Calcium Antagonists.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Male; Molecular Docking Simulation; Nifedipine; Proton Magnetic Resonance Spectroscopy | 2016 |
In search of the mutual relationship between the structure, solid-state spectroscopy and molecular dynamics in selected calcium channel blockers.
Topics: Calcium Channel Blockers; Crystallization; Dihydropyridines; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Nifedipine; Nimodipine; Nitrendipine; Quantum Theory; Spectrophotometry, Infrared; X-Ray Diffraction | 2016 |
Comparison of anti-anginal effect of cilnidipine with those of nicardipine and nifedipine in the vasopressin-induced angina model of rats.
Topics: Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Coronary Vasospasm; Coronary Vessels; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Male; Nicardipine; Nifedipine; Rats; Time Factors; Vasoconstriction; Vasodilator Agents; Vasopressins | 2016 |
The photobase generator nifedipine as a novel matrix for the detection of polyphenols in matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Catechin; Dihydropyridines; Indoles; Limit of Detection; Nifedipine; Photochemical Processes; Polymerization; Polyphenols; Protons; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2016 |
Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock.
Topics: Animals; Blood Glucose; Blood Pressure; Bradycardia; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Fat Emulsions, Intravenous; Female; Heart Arrest, Induced; Humans; Metabolome; Myocardial Contraction; Nifedipine; Pilot Projects; Shock; Swine; Tachycardia | 2016 |
Replacement of Amlodipine and Lercanidipine by Barnidipine: Tolerability and Effectiveness in a Real-Life Study.
Topics: Aged; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Substitution; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Product Surveillance, Postmarketing; Prospective Studies; Time Factors; Treatment Outcome | 2017 |
Ca
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Heart Rate; Isradipine; Mice, Inbred C57BL; Mice, Knockout; Nifedipine; Patch-Clamp Techniques; Sinoatrial Node | 2017 |
Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization.
Topics: Calcium Channel Blockers; Crystallization; Dihydropyridines; Molecular Conformation; Niacinamide; Nifedipine; Oxidation-Reduction; Photochemical Processes; Thermodynamics | 2017 |
Differences in Powder Properties of Two 1,4-Dihydropyridine-Type Compounds Evaluated through Thermal Analysis.
Topics: Calorimetry, Differential Scanning; Compressive Strength; Dihydropyridines; Lactose; Nifedipine; Nitrobenzenes; Piperazines; Stearic Acids; Tablets; Temperature | 2017 |
Selectivity of Ca
Topics: Animals; Antihypertensive Agents; Aorta; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Gastroesophageal Reflux; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Potassium Chloride; Rats, Wistar; Verapamil | 2018 |
Electrochemical, spectroscopic and molecular docking studies on the interaction of calcium channel blockers with dsDNA.
Topics: Animals; Binding Sites; Biosensing Techniques; Calcium Channel Blockers; Cattle; Dihydropyridines; DNA; Electrochemical Techniques; Intercalating Agents; Molecular Docking Simulation; Nifedipine; Nucleic Acid Conformation | 2019 |
Congruent release of drug and polymer: A "sweet spot" in the dissolution of amorphous solid dispersions.
Topics: Chemistry, Pharmaceutical; Dihydropyridines; Drug Carriers; Drug Liberation; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Scanning; Nifedipine; Polymers; Pyrrolidines; Solubility; Vinyl Compounds; X-Ray Microtomography | 2019 |
Long-chain fatty dihydropyridines: Docking calcium channel studies and antihypertensive activity.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Heart Rate; Hypertension; Male; Nifedipine; Pyridines; Rats; Rats, Wistar | 2020 |
Computational drug repositioning for ischemic stroke: neuroprotective drug discovery.
Topics: Algorithms; Animals; Apoptosis; Cell Line; Computational Biology; Dihydropyridines; Drug Discovery; Drug Repositioning; Humans; Ischemic Stroke; Mice; Neuroprotective Agents; Nifedipine; Oxidative Stress | 2021 |
Delayed Decline of Cognitive Function by Antihypertensive Agents: A Cohort Study Linked with Genotype Data.
Topics: Adrenergic Antagonists; Adult; Aged; Amlodipine; Antihypertensive Agents; Apolipoprotein E4; Calcium Channel Blockers; Cognition; Cohort Studies; Dihydropyridines; Diuretics; Diuretics, Potassium Sparing; Genotype; Humans; Hypertension; Nifedipine; Thiazides; Vasodilator Agents | 2022 |