nifedipine and chlorthalidone

nifedipine has been researched along with chlorthalidone in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199011 (33.33)18.7374
1990's10 (30.30)18.2507
2000's6 (18.18)29.6817
2010's6 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Ardeljan, M; Eison, HB; Garbowit, DL; Goldman, ME; Krakoff, LR; Phillips, RA; Shimabukuro, S2
Ballestra, AM; Cagianelli, A; Cipriani, M; Del Prato, C; Gandolfi, E; Innocenti, P; Magagna, A; Ponzanelli, F; Saba, P; Salvetti, A1
Calderón de la Barca Gázquez, JM; de Diego Cabrera, MS; González Santos, C; Iribarren Marín, MA; Martínez de la Iglesia, J; Pérula Torres, L1
Basciu, M; Cherchi, A; Pili, G; Sau, F; Seguro, C; Siddi, PP; Tamponi, R1
Liepinia, DJ; Skarda, IJ; Skards, JV; Vitols, AV; Voita, DU1
Ferrara, LA; Mancini, M; Marotta, T; Pasanisi, F; Rubba, P1
Ballestra, AM; Cagianelli, A; Cipriani, M; Del Prato, C; Gandolfi, E; Giuntoli, F; Innocenti, P; Magagna, A; Saba, P; Salvetti, A1
Fagan, TC1
Ferrara, LA; Mancini, M; Marotta, T; Mastranzo, P; Pasanisi, F1
Coxhead, PF; Douglas-Jones, AP1
Conway, J1
Beretta-Piccoli, C; Bianchetti, MG; Bomio, F; Luisoli, S; Marone, C; Weidmann, P2
de Simone, G; Fasano, ML; Ferrara, LA; Mancini, M; Pasanisi, F; Vallone, G1
Zhao, GS1
Del Guercio, R; Gentile, S1
Ambrosio, GB; Casiglia, E; Colangeli, G; Di Menza, G; Ginocchio, G; Mazza, A; Onesto, C; Pegoraro, L; Spolaore, P1
Alli, C; Avanzini, F; Bettelli, G; Colombo, F; Corso, R; Mariotti, G; Radice, M; Tognoni, G; Torri, V1
Florenciano Sánchez, R; Gómez Márquez, M; Martínez López, JJ; Molina Boix, M; Ortega González, G; Rúiz López, FJ1
Phillips, PJ; Popplewell, PY; Tallis, GA1
Huysmans, FT; van der Heijden, AG; van Hamersvelt, HW1
Bula, MS; Virna, MM; Zaremba, IeKh; Zaremba, OV; Zaremba-Fedchyshyn, OV1

Reviews

1 review(s) available for nifedipine and chlorthalidone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

17 trial(s) available for nifedipine and chlorthalidone

ArticleYear
The combination of chlorthalidone with nifedipine does not exert an additive antihypertensive effect in essential hypertensives: a crossover multicenter study.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:2

    Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine

1991
Normalization of left ventricular mass and associated changes in neurohormones and atrial natriuretic peptide after 1 year of sustained nifedipine therapy for severe hypertension.
    Journal of the American College of Cardiology, 1991, Volume: 17, Issue:7

    Topics: Atrial Natriuretic Factor; Cardiomegaly; Chlorthalidone; Delayed-Action Preparations; Echocardiography; Epinephrine; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Norepinephrine; Renin; Time Factors; Ventricular Function, Left

1991
[Comparison of chlorthalidone and sustained-action nifedipine in the treatment of mild to moderate arterial hypertension].
    Atencion primaria, 1990, Volume: 7, Issue:4

    Topics: Aged; Chlorthalidone; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Time Factors

1990
[Electrocardiographic and echocardiographic changes during antihypertensive therapy].
    Cardiologia (Rome, Italy), 1990, Volume: 35, Issue:12

    Topics: Acebutolol; Adolescent; Adult; Aged; Antihypertensive Agents; Captopril; Cardiomegaly; Chlorthalidone; Echocardiography; Electrocardiography; Female; Humans; Hypertension; Indenes; Male; Middle Aged; Nifedipine; Oxprenolol; Pindolol; Propanolamines; Timolol

1990
Calcium antagonists and thiazide diuretics in the treatment of hypertension.
    Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 10

    Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Renin; Sodium

1987
Chlorthalidone does not increase the hypotensive effect of nifedipine in essential hypertensives: a crossover multicentre study.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1989, Volume: 7, Issue:6

    Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Humans; Hypertension; Male; Middle Aged; Multicenter Studies as Topic; Nifedipine

1989
Addition of chlorthalidone to slow-release nifedipine in the treatment of arterial hypertension: a controlled study versus placebo.
    Cardiovascular drugs and therapy, 1988, Volume: 1, Issue:6

    Topics: Adult; Chlorthalidone; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Single-Blind Method

1988
A general practice trial of antihypertensive therapy comparing a combination of nicardipine and chlorthalidone with atenolol and chlorthalidone.
    The British journal of clinical practice, 1986, Volume: 40, Issue:3

    Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Middle Aged; Nicardipine; Nifedipine

1986
Third-line therapy. A cautionary note.
    Clinical and experimental hypertension. Part A, Theory and practice, 1985, Volume: 7, Issue:10

    Topics: Atenolol; Bendroflumethiazide; Captopril; Chlorthalidone; Female; Humans; Hypertension; Male; Methyldopa; Nifedipine

1985
Changes in left ventricular mass during a double-blind study with chlorthalidone and slow-release nifedipine.
    European journal of clinical pharmacology, 1984, Volume: 27, Issue:5

    Topics: Adult; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Heart; Humans; Hypertension; Male; Middle Aged; Nifedipine; Organ Size; Random Allocation

1984
Pressor factors and cardiovascular pressor responsiveness after short-term antihypertensive therapy with the calcium antagonist nifedipine alone or combined with a diuretic.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1984, Volume: 2, Issue:3

    Topics: Adult; Aged; Blood Pressure; Cardiovascular System; Chlorthalidone; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Pressoreceptors; Time Factors

1984
[Nifedipine and essential arterial hypertension refractory to hypotensive therapy: results of a preliminary double-blind study].
    La Clinica terapeutica, 1981, Jan-15, Volume: 96, Issue:1

    Topics: Adult; Aged; Chlorthalidone; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Pyridines; Reserpine

1981
Effect of two different therapeutic approaches on total and cardiovascular mortality in a Cardiovascular Study in the Elderly (CASTEL).
    Japanese heart journal, 1994, Volume: 35, Issue:5

    Topics: Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Clonidine; Drug Therapy, Combination; Female; Heart Diseases; Humans; Hypertension; Italy; Male; Nifedipine; Prospective Studies; Survival Analysis

1994
Antihypertensive efficacy and tolerability of different drug regimens in isolated systolic hypertension in the elderly.
    European heart journal, 1994, Volume: 15, Issue:2

    Topics: Aged; Aged, 80 and over; Amiloride; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Delayed-Action Preparations; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Nifedipine; Patient Satisfaction; Treatment Outcome

1994
[Evaluation of a combination of a diuretic and nifedipine retard for the treatment of hypertensive patients refractory to nifedipine retard].
    Anales de medicina interna (Madrid, Spain : 1984), 1993, Volume: 10, Issue:8

    Topics: Aged; Aged, 80 and over; Chlorthalidone; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Prospective Studies

1993
Foot volume increase on nifedipine is not prevented by pretreatment with diuretics.
    Journal of hypertension, 2004, Volume: 22, Issue:2

    Topics: Adult; Amiloride; Ankle; Body Weight; Calcium Channel Blockers; Chlorthalidone; Diuretics; Edema; Female; Foot Diseases; Hematocrit; Humans; Male; Natriuresis; Nifedipine; Osmotic Pressure; Premedication

2004
[Dynamics of the hemostasis parameters in patients with arterial hypertension in treatment with combined antihypertensive agents].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2014, Volume: 67, Issue:2 Pt 2

    Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Drug Administration Schedule; Drug Combinations; Female; Hemostasis; Humans; Hypertension; Male; Middle Aged; Nifedipine

2014

Other Studies

15 other study(ies) available for nifedipine and chlorthalidone

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Effects of nifedipine-GITS on left ventricular mass and left ventricular filling.
    Journal of cardiovascular pharmacology, 1992, Volume: 19 Suppl 2

    Topics: Atrial Natriuretic Factor; Cardiomegaly; Chlorthalidone; Delayed-Action Preparations; Drug Therapy, Combination; Echocardiography, Doppler; Electrocardiography; Epinephrine; Hemodynamics; Humans; Hypertension; Middle Aged; Nifedipine; Norepinephrine; Renin

1992
Haemodynamic resistance of forearm vessels during prolonged drug treatment of essential hypertension.
    Cor et vasa, 1990, Volume: 32, Issue:1

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clonidine; Drug Therapy, Combination; Forearm; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Propranolol; Vascular Resistance

1990
Acute reduction of blood pressure in asymptomatic patients with severe hypertension. An idea whose time has come--and gone.
    Archives of internal medicine, 1989, Volume: 149, Issue:10

    Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clonidine; Drug Administration Schedule; Humans; Hypertension; Nifedipine

1989
Body sodium-blood volume state, aldosterone, and cardiovascular responsiveness after calcium entry blockade with nifedipine.
    Kidney international, 1985, Volume: 28, Issue:4

    Topics: Aged; Aldosterone; Angiotensin II; Blood Volume; Calcium; Chlorthalidone; Drug Therapy, Combination; Edema; Epinephrine; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Norepinephrine; Renin; Sodium

1985
[A short-term clinical observation during the treatment of essential hypertension by atenolol composite tablets].
    Zhonghua xin xue guan bing za zhi, 1984, Volume: 12, Issue:4

    Topics: Adult; Atenolol; Chlorthalidone; Drug Combinations; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Tablets

1984
A cautionary tale.
    Australian family physician, 1997, Volume: 26, Issue:10

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Calcium Channel Blockers; Chlorthalidone; Contraindications; Diabetes Mellitus, Type 2; Heart Failure; Humans; Hypertension; Male; Nifedipine

1997