nifedipine has been researched along with 1,4-dihydropyridine in 142 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (31.69) | 18.7374 |
| 1990's | 60 (42.25) | 18.2507 |
| 2000's | 21 (14.79) | 29.6817 |
| 2010's | 16 (11.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bilodeau, L; Durroux, T; Gallo-Payet, N; Payet, MD | 1 |
| Howlett, SE; Nicholl, PA | 1 |
| Goldmann, S; Stoltefuss, J; Triggle, DJ; Zheng, W | 1 |
| Latifpour, J; Weiss, RM; Yoshida, M | 1 |
| Benterbusch, R; Herberg, FW; Melzer, W; Thieleczek, R | 1 |
| Cuccaro, ML; Jacobs, LS; Lorenson, MY | 1 |
| Furukawa, T; Katsuragi, T; Ogawa, S; Shirakabe, K; Soejima, O | 1 |
| Bacskai, BJ; Friedman, PA | 1 |
| Peers, C | 1 |
| Dubyak, GR; Jones, SW; Marks, TN | 1 |
| Brocklehurst, KW; Ceña, V; Pollard, HB; Rojas, E | 1 |
| Suszkiw, JB; Tomsig, JL | 1 |
| Fitzpatrick, LA; Jones, JI | 1 |
| Dale, N; Edmonds, B; Kandel, ER; Klein, M | 1 |
| Langs, DA; Strong, PD; Triggle, DJ | 1 |
| Hosey, MM; McMahon, KK; Ptasienski, J | 1 |
| Carpenter, CL; Cooper, EC; Greenberg, DA | 1 |
| Lee, HR; Roeske, WR; Watson, M; Yamamura, HI | 1 |
| Brown, AM; Dumont, L; Grupp, G; Grupp, IL; Hamilton, S; Schwartz, A; Vaghy, PL; Williams, JS; Yatani, A | 1 |
| Schramm, M; Towart, R | 1 |
| Litzinger, MJ; Nelson, PG; Pun, RY | 1 |
| Creba, JA; Karobath, M | 1 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Callewaert, G; Droogmans, G | 1 |
| Kongsamut, S; Miller, RJ | 1 |
| Bean, BP; Hermsmeyer, K; Puga, A; Sturek, M | 1 |
| Bean, BP; Hess, P; Lansman, JB; Nilius, B; Nowycky, MC; Tsien, RW | 1 |
| Gurney, AM; Nerbonne, JM | 1 |
| Dunlap, K; Holz, GG; Rane, SG | 1 |
| Dunlap, K; Holz, GG; Kream, RM | 1 |
| Cadet, JL; Freed, WJ; Taylor, E | 1 |
| Massieu, L; Tapia, R | 1 |
| Catt, KJ; Hausdorff, WP | 1 |
| Bogónez, E; Martínez-Serrano, A; Satrústegui, J; Vitórica, J | 1 |
| Anderson, EG; Scroggs, RS | 1 |
| Olsen, R; Powis, G; Seewald, M | 1 |
| Al-Dahan, MI; Thalmann, RH | 1 |
| Aaronson, PI; Bolton, TB; Lang, RJ; MacKenzie, I | 1 |
| Jones, SW; Marks, TN | 1 |
| Aizawa, T; Komatsu, M; Nagasawa, Y; Takeda, T; Yamada, T; Yokokawa, N | 1 |
| Goldin, SM; Turner, TJ | 1 |
| Freedman, SB; Kongsamut, S; Miller, RJ | 1 |
| Bolger, GT; Rafferty, MF; Skolnick, P | 1 |
| Arrowsmith, JE; Blackburn, KJ; Burges, RA; Campbell, SF; Cross, PE; Gardiner, DG; Stubbs, JK | 1 |
| Chhabra, A; Fairhurst, AS; Thayer, SA; Welcome, M | 1 |
| Dubur, GJ; Gendvilienè, VI; Kimenis, AA; Macianskiene, RA; Narusevicius, EV; Selga, MJ; Simkhovich, BZ; Velena, AH; Vitolina, RO; Zarinsh, GV | 1 |
| Barrett, JE; Bolger, GT; Lueddens, H; Paul, SM; Skolnick, P; Weissman, BA; Witkin, J | 1 |
| Campbell, KP; Kahl, SD; Sharp, A; Strom, M | 1 |
| Bäärnhielm, C; Hansson, G | 1 |
| Bowling, N; Conery, BG; Hayes, JS; Kauffman, RF | 1 |
| Brandt, NR; Caswell, AH; Kawamoto, RM | 1 |
| Bolger, GT; Crawley, JN; Paul, SM; Rafferty, MF; Skolnick, P | 1 |
| Giacomini, JC; Giacomini, KM; Nelson, WL; Zobrist, RH | 1 |
| Cavero, I; Spedding, M | 1 |
| Kass, RS; Sanguinetti, MC | 1 |
| Jones, H; Khandwala, A; Van Inwegen, RG; Weinryb, I | 1 |
| Bolger, G; Fraser, CM; Jung, CY; Schaber, JS; Triggle, DJ; Venter, JC | 1 |
| Freedman, SB; Miller, RJ | 1 |
| Altura, BM; Altura, BT | 1 |
| Luu, MD; Martin, JV; Mendelson, WB; Paul, SM; Skolnic, P; Wagner, R | 1 |
| de Boland, AR; Vazquez, G | 1 |
| Bagó, A; Deák, F; Hunyady, L; Rohács, T; Spät, A | 1 |
| Dockrell, ME; Haynes, WG; Olverman, HJ; Waugh, CJ; Webb, DJ; Williams, BC | 1 |
| Mizusawa, H; Omote, M | 1 |
| Hettrick, DA; Pagel, PS; Warltier, DC | 1 |
| Browaeys-Poly, E; Guilbault, P; Ouadid, H; Vilain, JP | 1 |
| Croxton, TL; Farley, LS; Hirshman, CA; Vannier, C | 1 |
| Berger, AJ; Umemiya, M | 1 |
| Calabresi, P; De Murtas, M; Marciani, MG; Mercuri, NB; Pisani, A; Stefani, A | 1 |
| Astier, H; Grazzini, E; Guipponi, M; Roussel, JP | 1 |
| Carbone, E; Magnelli, V; Pollo, A; Sher, E | 1 |
| Furberg, CD; Meyer, JV; Psaty, BM | 1 |
| Kimura, T; Satoh, S; Takeuchi, A | 1 |
| Baldelli, P; Birnbaumer, L; Neely, A; Olcese, R; Stefani, E; Wei, X | 1 |
| Bockaert, J; Chavis, P; Fagni, L; Shinozaki, H | 1 |
| Chaylakhyan, LM; Grishchenko, VM; Zherelova, OM | 1 |
| Friedman, PA; Gesek, FA | 1 |
| Beevers, DG; Sleight, P | 1 |
| Dhein, S; Klaus, W; Salameh, A; Simsek, S; Zhao, Y | 1 |
| Kugiyama, K; Ogawa, H; Okumura, K; Tsuchiya, T; Yasue, H | 1 |
| Gizinski, MJ; Schumaker, KS | 1 |
| Brown, DA; Filippov, AK | 1 |
| Katina, IE; Lukyanenko, V; Nasledov, GA; Terentyev, DA | 1 |
| Leenen, FH | 1 |
| Fischmeister, R; Hoerter, J; Hove-Madsen, L; Legssyer, AK | 1 |
| Fujiki, H; Hirano, T; Miyakoda, G; Mori, T; Ohura, M; Orito, K | 1 |
| Gan, J; Iuvone, PM | 1 |
| Balon, TW; Young, JC | 1 |
| Leng, L; O'Neil, RG | 1 |
| Arnoux, A; Cannon, R; Hammond, C; Kordon, C; Kwiecien, R; Robert, C; Vigues, S | 1 |
| Ouadid-Ahidouch, H | 1 |
| van Zwieten, PA | 1 |
| Kanaya, N; Kawana, S; Kimura, H; Matsumoto, M; Miyamoto, A; Namiki, A; Ohshika, H; Tsuchida, H | 1 |
| Atchison, WD; Hewett, SJ; Xu, YF | 1 |
| Aicardi, G; Bisi, A; Budriesi, R; Campana, G; Chiarini, A; Rampa, A; Spampinato, S; Valenti, P; Zaza, A | 1 |
| Evans, GJ; Pocock, JM | 1 |
| Ahtee, L; Kivastik, T; Piepponen, TP; Zharkovsky, A | 1 |
| Hoischen, S; Hullin, R; Reuter, H; Schwinger, RH | 1 |
| Guertin, PA; Hounsgaard, J | 1 |
| Arabidze, GG; Birkenhäger, WH; Bulpitt, CJ; Celis, H; de Leeuw, P; Dollery, CT; Duggan, J; Fagard, RH; Fletcher, AE; Gasowski, J; Kawecka-Jaszcz, K; Leonetti, G; Nachev, C; Rodico, JL; Rosenfeld, J; Safar, M; Seux, ML; Staessen, JA; Thijs, L; Tuomilehto, J; Webster, J; Yodfat, Y | 1 |
| Gao, X; Gillman, MW; Goldman, L; Hertzmark, E; McLaughlin, TJ; Ross-Degnan, D; Soumerai, SB; Spiegelman, D | 1 |
| Grant, KA; Green, KL | 1 |
| Alvarez, U; Duncan, R; Harter, L; Hruska, K; Kizer, N | 1 |
| Gonon, A; Nordlander, M; Rydén, L; Segawa, D; Sjöquist, PO; Wang, QD | 1 |
| Drew, T; Jinnah, HA; Kim, BS; Rothstein, JD; Visser, JE; Yitta, S | 1 |
| Doris, PA; Kähönen, M; Kalliovalkama, J; Pekki, A; Pörsti, I; Tolvanen, JP; Voipio, J; Wu, X; Ylitalo, P | 1 |
| Arora, KK; Diedrich, K; Katzur, AC; Ortmann, O; Schultze-Mosgau, A; Stojilkovic, SS | 1 |
| Protas, L; Robinson, RB | 1 |
| Bito, H; Boutillier, AL; Loeffler, JP; Sée, V | 1 |
| Bosnjak, ZJ; Contney, SJ; Kwok, CS; Nicolosi, AC; Olinger, GN | 1 |
| Kan, E; Kelly, JE; Lokuta, AJ; Nishio, M; Sagawa, K; Sagawa, T; Tsai, J; Wasserstrom, JA | 1 |
| Gerzanich, V; Simard, JM; West, GA; Zhang, F | 1 |
| Bidet, M; Martial, S; Martin, D; Melendez, E; Namorado, MD; Poujeol, C; Poujeol, P; Reyes, JL; Sanchez, E; Tauc, M; Valencia, L | 1 |
| MacGregor, GA; Missouris, CG; Sirker, A | 1 |
| Brown, G; Losonczy, G; Schoenl, M; Venuto, R | 1 |
| Devereux, RB; Palmieri, V | 1 |
| Dondoni, A; Massi, A | 1 |
| Boffi, F; Congiu Castellano, A; Dell'Ariccia, M; Grande, S; Marzi, S; Rosi, A; Viti, V | 1 |
| Handler, J | 1 |
| Honda, A; Ishiguro, M; Russell, SR; Tranmer, BI; Wellman, GC; Wellman, TL | 1 |
| Belluti, F; Bisi, A; Budriesi, R; Chiarini, A; Gobbi, S; Ioan, P; Piazzi, L; Rampa, A; Valenti, P | 1 |
| Barclay, LR; Ingold, KU; Lin, S; Litwinienko, G; MacLean, PD; Mulder, P | 1 |
| Alipour, E; Davood, A; Mansouri, N; Rerza Dehpour, A; Shafaroudi, H; Shafiee, A | 1 |
| Mielcarek, J; Naskrent, M | 1 |
| Berenshteĭn, NV; Burmistrova, LF; Iskenderov, BG; Lokhina, TV | 1 |
| Iwata, S; Koganei, H; Shoji, M | 1 |
| Lee, YH; Li, CL; Lu, HK; Tseng, CC; Wang, LF | 1 |
| Cao, S; Chang, CC; Dunne, SF; Kai, L; Kang, S; Luan, CH; Pandey, P; Silverman, RB; Surmeier, DJ; Tian, X | 1 |
| Chen, C; Shaikh, AC | 1 |
| Piñeros, MA; Tester, M | 1 |
| Barbier, O; Bidet, M; Martial, S; Melendez, E; Poujeol, P; Reyes, JL; Sanchez, E; Tauc, M | 1 |
| DeDea, L | 1 |
| Chen, YC; Lee, HW; Li, CL; Lin, SJ; Lu, HK; Wang, LF | 1 |
| Kazama, I; Maruyama, Y; Matsubara, M | 1 |
| Cropper, EC; Evans, CG; Svensson, E | 1 |
| El-Hamamsy, MH; El-Moselhy, TF; Saleh, DO; Shaldam, MA | 1 |
| Chudoba, D; Drużbicki, K; Jarek, M; Jenczyk, J; Kiwilsza, A; Mielcarek, J; Pajzderska, A; Wąsicki, J | 1 |
| Bisenieks, E; Duburs, G; Gall Troselj, K; Krauze, A; Poikans, J; Velena, A; Zarkovic, N | 1 |
| Beuhler, MC; Kerns, WP; Murphy, CM; Nicholson, B; Quinn, ME; Shoe, T; Williams, C | 1 |
| Bao, J; Mei, X; Wang, JR; Yan, Z; Yu, Q | 1 |
| Acone, B; Calcullo, C; Crippa, M; De Luca, N; Desideri, G; Gaudio, GV; Lonati, LM; Orselli, L; Roca, E; Scuteri, A; Tocci, G; Vulpis, V; Zaninelli, A | 1 |
| Harding, SE; Maxwell, LJ; Pope, J; Rirash, F; Tanjong Ghogomu, E; Tingey, PC; Tugwell, P; Wells, GA | 1 |
12 review(s) available for nifedipine and 1,4-dihydropyridine
| Article | Year |
|---|---|
Modulation of calcium channel function by drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Electric Conductivity; Heart Rate; Homeostasis; Humans; Ion Channels; Membrane Potentials; Nifedipine; Pyridines; Receptors, Cell Surface; Structure-Activity Relationship | 1985 |
Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic beta-Agonists; Animals; Calcium; Dihydropyridines; In Vitro Techniques; Ion Channels; Isoproterenol; Kinetics; Models, Biological; Nifedipine; Phosphorylation; Pyridines; Receptors, Adrenergic, beta | 1986 |
"Calcium antagonists": a class of drugs with a bright future. Part II. Determination of basic pharmacological properties.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Electrophysiology; Heart Rate; Ion Channels; Lanthanum; Methods; Muscle, Smooth; Myocardial Contraction; Nifedipine; Potassium; Pyridines; Receptors, Adrenergic, alpha; Stereoisomerism; Verapamil | 1984 |
Are dihydropyridine binding sites voltage sensitive calcium channels?
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Ion Channels; Muscle, Smooth; Muscles; Myocardium; Neurons; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Pyridines | 1984 |
Microcirculatory actions and uses of naturally-occurring (magnesium) and novel synthetic calcium channel blockers.
Topics: Anesthesia; Animals; Arterioles; Blood Pressure; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cerebrovascular Circulation; Cerebrovascular Disorders; Coronary Disease; Diabetes Mellitus; Dihydropyridines; Female; Humans; Hypertension; Ketamine; Magnesium; Magnesium Deficiency; Microcirculation; Muscle, Smooth, Vascular; Muscles; Nifedipine; Nisoldipine; Nitrendipine; Nutritional Requirements; Pentobarbital; Pre-Eclampsia; Pregnancy; Pyridines; Rats; Vasoconstrictor Agents; Vasodilator Agents; Venules | 1984 |
Nifedipine. Dose-related increase in mortality in patients with coronary heart disease.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Confidence Intervals; Coronary Disease; Depression, Chemical; Dihydropyridines; Dose-Response Relationship, Drug; Hemorrhage; Humans; Hypotension; Myocardial Contraction; Myocardial Ischemia; Nifedipine; Odds Ratio; Renin-Angiotensin System; Sympathetic Nervous System; Time Factors | 1995 |
Short acting dihydropyridine (vasodilating) calcium channel blockers for hypertension: is there a risk?
Topics: Calcium Channel Blockers; Case-Control Studies; Clinical Trials as Topic; Dihydropyridines; Humans; Hypertension; Myocardial Ischemia; Nifedipine; Sensitivity and Specificity | 1996 |
Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Dogs; Guinea Pigs; Hypertension; Nifedipine; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1998 |
Angiotensin converting enzyme inhibition and dihydropyridine calcium channel blockade in the treatment of left ventricular hypertrophy in arterial hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Diuretics; Drug Therapy, Combination; Enalapril; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Meta-Analysis as Topic; Nifedipine; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Sodium Chloride Symporter Inhibitors; Time Factors; Ventricular Dysfunction, Left | 2002 |
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.
Topics: Amlodipine; Animals; Antioxidants; Azetidinecarboxylic Acid; Calcium Channel Blockers; Cattle; Dihydropyridines; Epithelial Cells; Humans; Hydrogen; Lipoproteins, LDL; Mice; Microsomes; Mitochondria; Niacinamide; Nifedipine; Nitrobenzenes; Oxidants; Oxidative Stress; Piperazines | 2016 |
How to Improve Effectiveness and Adherence to Antihypertensive Drug Therapy: Central Role of Dihydropyridinic Calcium Channel Blockers in Hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Essential Hypertension; Humans; Medication Adherence; Nifedipine; Risk Factors; Treatment Outcome; Vasodilator Agents | 2018 |
Calcium channel blockers for primary and secondary Raynaud's phenomenon.
Topics: Calcium Channel Blockers; Dihydropyridines; Humans; Nifedipine; Pain Management; Placebos; Publication Bias; Randomized Controlled Trials as Topic; Raynaud Disease; Severity of Illness Index | 2017 |
2 trial(s) available for nifedipine and 1,4-dihydropyridine
| Article | Year |
|---|---|
Systolic Hypertension in Europe (Syst-Eur) trial phase 2: objectives, protocol, and initial progress. Systolic Hypertension in Europe Investigators.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Determination; Calcium Channel Blockers; Dihydropyridines; Drug Administration Schedule; Drug Therapy, Combination; Enalapril; Europe; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Nifedipine; Prognosis; Survival Rate; Treatment Outcome | 1999 |
[Hypotensive efficacy and tolerability of combination of dihydropyridine and non-dihydropyridine calcium antagonists in the treatment of patients with arterial hypertension].
Topics: Adult; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Dihydropyridines; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nifedipine; Obesity; Treatment Outcome; Verapamil | 2007 |
128 other study(ies) available for nifedipine and 1,4-dihydropyridine
| Article | Year |
|---|---|
Background calcium permeable channels in glomerulosa cells from adrenal gland.
Topics: Aldosterone; Animals; Biological Transport; Calcium; Calcium Channels; Cattle; Cell Membrane Permeability; Cells, Cultured; Dihydropyridines; Electric Conductivity; Membrane Potentials; Nifedipine; Rats; Zona Glomerulosa | 1992 |
Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters.
Topics: Aging; Allosteric Site; Animals; Calcium Channels; Cricetinae; Dihydropyridines; Diltiazem; In Vitro Techniques; Kinetics; Male; Myocardium; Nifedipine; Verapamil | 1992 |
Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arteries; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; Drug Antagonism; Heart; In Vitro Techniques; Isradipine; Male; Muscle Contraction; Nifedipine; Radioligand Assay; Rats | 1992 |
Evidence for the presence of regional differences in the calcium antagonist receptors in lower urinary tract smooth muscle.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Carbachol; Dihydropyridines; Drug Interactions; Female; Isradipine; Muscle Contraction; Muscle, Smooth; Nifedipine; Rabbits; Urinary Tract | 1992 |
Excitation-contraction coupling in a pre-vertebrate twitch muscle: the myotomes of Branchiostoma lanceolatum.
Topics: Animals; Blotting, Western; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cell Movement; Chordata, Nonvertebrate; Dihydropyridines; Membrane Potentials; Microsomes; Muscle Contraction; Nifedipine; Ryanodine; Verapamil | 1992 |
Calcium release from pituitary secretory granules: modulation by thiols, disulfides, and dihydropyridine calcium channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cattle; Cysteine; Cystine; Cytoplasmic Granules; Dihydropyridines; Disulfides; Dithiothreitol; Glutathione; Hydrogen-Ion Concentration; Mercaptoethanol; Nifedipine; Nimodipine; Pituitary Gland; Potassium Chloride; Sulfhydryl Compounds | 1990 |
Involvement of dihydropyridine-sensitive Ca2+ channels in adenosine-evoked inhibition of acetylcholine release from guinea pig ileal preparation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Acetylcholine; Adenosine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Calcium Channels; Chromatography, High Pressure Liquid; Dihydropyridines; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle, Smooth; Nifedipine; Physostigmine; Tetrodotoxin; Theophylline | 1990 |
Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Absorption; Animals; Biological Transport; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Dihydropyridines; Epithelium; Exocytosis; Kidney Tubules, Distal; Kinetics; Mice; Microtubules; Nifedipine; Parathyroid Hormone; Peptide Fragments | 1990 |
Hypoxic suppression of K+ currents in type I carotid body cells: selective effect on the Ca2(+)-activated K+ current.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Calcium Channel Blockers; Carotid Body; Dihydropyridines; Electrophysiology; Hypoxia; Nifedipine; Potassium; Rats | 1990 |
Calcium currents in the A7r5 smooth muscle-derived cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Biological Transport; Calcium; Calcium Channels; Cell Line; Colforsin; Cytosol; Dihydropyridines; Electric Conductivity; Fluorescence; Isoproterenol; Ligands; Muscle, Smooth, Vascular; Nifedipine; Potassium | 1990 |
Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Cadmium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Dihydropyridines; Electric Conductivity; Membrane Potentials; Nifedipine; Pertussis Toxin; Verapamil; Virulence Factors, Bordetella | 1991 |
Permeation of Pb2+ through calcium channels: fura-2 measurements of voltage- and dihydropyridine-sensitive Pb2+ entry in isolated bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium Channels; Cattle; Cell Membrane Permeability; Cell Separation; Dihydropyridines; Fura-2; Lead; Membrane Potentials; Nifedipine | 1991 |
Binding of [125I]iodipine to parathyroid cell membranes: evidence of a dihydropyridine-sensitive calcium channel.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Iodine Radioisotopes; Iodobenzenes; Kinetics; Ligands; Nicotinic Acids; Nifedipine; Oxadiazoles; Parathyroid Glands; Stereoisomerism | 1990 |
Contributions of two types of calcium channels to synaptic transmission and plasticity.
Topics: Action Potentials; Animals; Aplysia; Cadmium; Calcium Channels; Cells, Cultured; Dihydropyridines; Electric Conductivity; FMRFamide; Motor Neurons; Neuronal Plasticity; Neurons, Afferent; Neuropeptides; Nifedipine; Serotonin; Synapses; Synaptic Transmission | 1990 |
Receptor model for the molecular basis of tissue selectivity of 1, 4-dihydropyridine calcium channel drugs.
Topics: Amino Acid Sequence; Binding Sites; Calcium Channel Blockers; Calcium Channels; Computer Simulation; Dihydropyridines; Drug Design; Models, Molecular; Molecular Conformation; Molecular Structure; Nifedipine; Receptors, Nicotinic; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
High and low affinity states of the dihydropyridine and phenylalkylamine receptors on the cardiac calcium channel and their interconversion by divalent cations.
Topics: Animals; Calcium; Cations, Divalent; Chickens; Dihydropyridines; Heart; Ion Channels; Isradipine; Magnesium; Myocardium; Nifedipine; Nitrendipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1985 |
Stimulation of calcium uptake in PC12 cells by the dihydropyridine agonist BAY K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Gland Neoplasms; Animals; Calcium; Cell Line; Dihydropyridines; Dose-Response Relationship, Drug; Nifedipine; Nitrendipine; Pheochromocytoma; Pyridines; Rats | 1985 |
Decreased [3H]nitrendipine binding in the brainstem of deoxycorticosterone-NaCl hypertensive rats.
Topics: Animals; Brain Stem; Calcium; Desoxycorticosterone; Dihydropyridines; Hypertension; Ion Channels; Kidney; Kinetics; Male; Myocardium; Nephrectomy; Nifedipine; Nitrendipine; Organ Size; Pyridines; Rats; Sodium Chloride | 1985 |
Profile of the oppositely acting enantiomers of the dihydropyridine 202-791 in cardiac preparations: receptor binding, electrophysiological, and pharmacological studies.
Topics: Animals; Binding, Competitive; Calcium; Dihydropyridines; Dogs; Electric Conductivity; Guinea Pigs; Heart; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Nitrendipine; Papillary Muscles; Pyridines; Sarcolemma; Stereoisomerism; Ventricular Function | 1985 |
Effects of nitrendipine on the voltage-sensitive calcium channel in mammalian sensory neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Dihydropyridines; Electric Stimulation; Ethanol; Ganglia, Spinal; Ion Channels; Mice; Nerve Growth Factors; Neurons, Afferent; Nifedipine; Nitrendipine; Pharmaceutical Vehicles; Pyridines; Reaction Time; Temperature | 1985 |
The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aminoquinolines; Animals; Brain Chemistry; Calcium; Calcium Channel Blockers; Cell Line; Dihydropyridines; Electric Stimulation; Glioma; In Vitro Techniques; Ion Channels; Neuroblastoma; Neurons; Nifedipine; Potassium; Pyridines; Rats; Synaptosomes; Verapamil | 1986 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
Ca2+-channel current and its modification by the dihydropyridine agonist BAY k 8644 in isolated smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Barium; Barium Compounds; Cell Membrane; Cesium; Chlorides; Dihydropyridines; Guinea Pigs; Ileum; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscle, Smooth; Nifedipine; Pyridines | 1986 |
Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bucladesine; Calcium; Cell Differentiation; Dihydropyridines; Nerve Growth Factors; Nifedipine; Nitrendipine; Norepinephrine; Pheochromocytoma; Potassium; Pyridines; Rats; Secretory Rate | 1986 |
Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dihydropyridines; Ion Channels; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Nitrendipine; Pyridines; Rats | 1986 |
Blockade of Ca2+ and K+ currents in bag cell neurons of Aplysia californica by dihydropyridine Ca2+ antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aplysia; Calcium; Calcium Channel Blockers; Dihydropyridines; Ion Channels; Kinetics; Mathematics; Neurons; Nifedipine; Nisoldipine; Potassium; Pyridines | 1987 |
Dihydropyridine inhibition of neuronal calcium current and substance P release.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Chickens; Dihydropyridines; Electric Stimulation; Ganglia, Spinal; Ion Channels; Kinetics; Neurons; Nifedipine; Pyridines; Substance P | 1987 |
Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Chick Embryo; Dihydropyridines; Electric Stimulation; Ganglia, Spinal; Nifedipine; Substance P | 1988 |
The iminodipropionitrile (IDPN)-induced dyskinetic syndrome in mice: antagonism by the calcium channel antagonist nifedipine.
Topics: Animals; Binding Sites; Brain; Calcium; Dihydropyridines; Dyskinesia, Drug-Induced; Female; Ion Channels; Mice; Nifedipine; Nitriles | 1988 |
Relationship of dihydropyridine binding sites with calcium-dependent neurotransmitter release in synaptosomes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Aminopyridines; Animals; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; gamma-Aminobutyric Acid; Ion Channels; Isradipine; Lanthanum; Male; Mice; Neurotransmitter Agents; Nifedipine; Nitrendipine; Oxadiazoles; Potassium; Receptors, Nicotinic; Ruthenium Red; Synaptosomes | 1988 |
Activation of dihydropyridine-sensitive calcium channels and biphasic cytosolic calcium responses by angiotensin II in rat adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium; Calcium Channels; Cattle; Cytosol; Dihydropyridines; Ethers; Ionomycin; Kinetics; Male; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Species Specificity; Spectrometry, Fluorescence; Zona Glomerulosa | 1988 |
Reduction of K+-stimulated 45Ca2+ influx in synaptosomes with age involves inactivating and noninactivating calcium channels and is correlated with temporal modifications in protein dephosphorylation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aging; Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Dihydropyridines; Kinetics; Male; Molecular Weight; Nifedipine; Phosphoproteins; Phosphorylation; Potassium; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Serotonin modulates calcium-dependent plateau of action potentials recorded from bull frog A-type sensory neurons which is omega-conotoxin GVIA-sensitive, but dihydropyridine-insensitive.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Dihydropyridines; Ganglia, Spinal; In Vitro Techniques; Mollusk Venoms; Neurons, Afferent; Nifedipine; omega-Conotoxin GVIA; Rana catesbeiana; Serotonin; Tetraethylammonium Compounds | 1989 |
Contribution of external and internal Ca2+ to changes in intracellular free Ca2+ produced by mitogens in Swiss 3T3 fibroblasts: the role of dihydropyridine sensitive Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cell Line; Cytosol; Dihydropyridines; Extracellular Space; Fibroblasts; Mice; Mitogens; Nifedipine; Platelet-Derived Growth Factor | 1989 |
Effects of dihydropyridine calcium channel ligands on rat brain gamma-aminobutyric acidB receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Baclofen; Binding, Competitive; Calcium Channels; Dihydropyridines; Male; Nifedipine; Rats; Receptors, GABA-A | 1989 |
Calcium currents in single isolated smooth muscle cells from the rabbit ear artery in normal-calcium and high-barium solutions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channels; Dihydropyridines; Ear; Electric Conductivity; Membrane Potentials; Muscle, Smooth, Vascular; Nifedipine; Rabbits | 1988 |
Calcium currents in bullfrog sympathetic neurons. I. Activation kinetics and pharmacology.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Cadmium; Calcium Channel Agonists; Calcium Channels; Dihydropyridines; Ganglia, Sympathetic; Kinetics; Membrane Potentials; Neurons; Nifedipine; Rana catesbeiana; Saxitoxin; Second Messenger Systems | 1989 |
Pharmacological characterization of the voltage-dependent calcium channel of pancreatic B-cell.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophysiology; Glucose; Insulin; Islets of Langerhans; Male; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Osmolar Concentration; Potassium; Potassium Chloride; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Calcium channels in rat brain synaptosomes: identification and pharmacological characterization. High affinity blockade by organic Ca2+ channel blockers.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Ion Channels; Male; Nifedipine; Nitrendipine; Norepinephrine; Potassium; Pyridines; Rats; Rats, Inbred Strains; Synaptosomes | 1985 |
Dihydropyridine sensitive calcium channels in a smooth muscle cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Cell Line; Cobalt; Dihydropyridines; Ion Channels; Muscle, Smooth, Vascular; Nifedipine; Nitrendipine; Potassium; Pyridines; Rats | 1985 |
Phencyclidine increases the affinity of dihydropyridine calcium channel antagonist binding in rat brain.
Topics: Animals; Binding Sites; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Kinetics; Magnesium; Male; Nifedipine; Nitrendipine; Phencyclidine; Pyridines; Rats; Rats, Inbred Strains | 1985 |
Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents.
Topics: Amlodipine; Animals; Biological Assay; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Dogs; Guinea Pigs; Hemodynamics; Kinetics; Male; Nifedipine; Pyridines; Rats; Vasoconstriction | 1986 |
Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Dioxanes; Gallopamil; In Vitro Techniques; Nicardipine; Nifedipine; Pyridines; Quinuclidinyl Benzilate; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Nicotinic; Stereoisomerism | 1985 |
Effect of ryodipine on electromechanical parameters of heart and vessels, cAMP phosphodiesterase activity and swelling-contraction cycle of mitochondria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anura; Calcium Channel Blockers; Cardiovascular Agents; Cattle; Dihydropyridines; Electric Stimulation; Electrophysiology; Heart; In Vitro Techniques; Mitochondria; Mitochondria, Liver; Mitochondrial Swelling; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nifedipine; Pyridines; Rabbits; Rats | 1985 |
Dihydropyridine calcium channel antagonists binding in non-mammalian vertebrates: characterization and relationship to 'peripheral-type' binding sites for benzodiazepines.
Topics: Animals; Brain; Calcium Channels; Columbidae; Dihydropyridines; Female; Kinetics; Lizards; Male; Membranes; Myocardium; Nifedipine; Nitrendipine; Pyridines; Rana catesbeiana; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Nicotinic; Species Specificity; Trout | 1986 |
High-affinity antibodies to the 1,4-dihydropyridine Ca2+-channel blockers.
Topics: Animals; Antibodies; Antibody Specificity; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Nifedipine; Nitrendipine; Pyridines; Rabbits; Receptors, Nicotinic; Structure-Activity Relationship; Tritium | 1986 |
Oxidation of 1,4-dihydropyridines by prostaglandin synthase and the peroxidic function of cytochrome P-450. Demonstration of a free radical intermediate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cytochrome P-450 Enzyme System; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Free Radicals; Glutathione; In Vitro Techniques; Male; Microsomes; Nifedipine; Oxidation-Reduction; Oxygen Consumption; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred Strains | 1986 |
Phosphorylation of ventricular sarcolemmal membranes does not alter binding properties of nitrendipine.
Topics: Alamethicin; Animals; Cats; Dihydropyridines; Dose-Response Relationship, Drug; Female; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Myocardium; Nifedipine; Nitrendipine; Phosphorylation; Protein Kinases; Pyridines; Sarcolemma; Time Factors | 1985 |
Effects of mercaptans upon dihydropyridine binding sites on transverse tubules isolated from triads of rabbit skeletal muscle.
Topics: Animals; Digoxin; Dihydropyridines; Dithiothreitol; Glutathione; Glutathione Disulfide; Muscles; Nifedipine; Nitrendipine; Ouabain; Pyridines; Rabbits; Sulfhydryl Compounds | 1985 |
Effects of calcium antagonists on phencyclidine behaviors.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Male; Mice; Motor Activity; Motor Skills; Nifedipine; Phencyclidine; Prazosin; Pyridines; Verapamil | 1986 |
The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Dihydropyridines; Heart; Kinetics; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Drug; Structure-Activity Relationship; Verapamil | 1986 |
Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.
Topics: Animals; Binding Sites; Cattle; Dihydropyridines; Electrophysiology; Heart Conduction System; Ion Channels; Membrane Potentials; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Purkinje Fibers; Pyridines; Verapamil | 1984 |
Comparative structure-activity relationships for dihydropyridines as inhibitors of [3H]-nitrendipine binding vs cyclic nucleotide phosphodiesterases.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Binding, Competitive; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Kinetics; Male; Myocardium; Nifedipine; Nitrendipine; Pyridines; Rats; Structure-Activity Relationship | 1984 |
Molecular properties of the slow inward calcium channel. Molecular weight determinations by radiation inactivation and covalent affinity labeling.
Topics: Affinity Labels; Animals; Calcium; Dihydropyridines; Guinea Pigs; Ion Channels; Methods; Molecular Weight; Muscles; Nifedipine; Nitrendipine; Pyridines | 1983 |
Diazepam-stimulated increases in the synaptosomal uptake of 45Ca2+: reversal by dihydropyridine calcium channel antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Chloride; Calcium Radioisotopes; Cerebral Cortex; Diazepam; Dihydropyridines; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Synaptosomes | 1984 |
"Stimulation of dihydropyridine-sensitive Ca2+ influx in cultured myoblasts by 1,25(OH)2-vitamin D3".
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcitriol; Calcium Channels; Cells, Cultured; Chick Embryo; Dihydropyridines; Egtazic Acid; Muscles; Nifedipine; Rats; Rats, Wistar | 1993 |
Dihydropyridine-sensitive initial component of the ANG II-induced Ca2+ response in rat adrenal glomerulosa cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium; Calcium Channels, L-Type; Dihydropyridines; Female; Manganese; Membrane Potentials; Muscle Proteins; Nifedipine; Potassium; Rats; Rats, Wistar; Zona Glomerulosa | 1994 |
Modulators of calcium and potassium channels: their effects on endothelin-1 binding to cardiac membranes.
Topics: Animals; Benzopyrans; Calcium Channels; Cromakalim; Dihydropyridines; Endothelins; Heart; In Vitro Techniques; Male; Membranes; Myocardium; Nifedipine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Effects of cyclopiazonic acid on phenylephrine-induced contractions in the rabbit ear artery.
Topics: Animals; Arteries; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Charybdotoxin; Dihydropyridines; Ear; Electrophysiology; Endothelium, Vascular; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Potassium Channel Blockers; Rabbits; Sarcoplasmic Reticulum; Scorpion Venoms | 1994 |
Left ventricular mechanical consequences of dihydropyridine calcium channel modulation in conscious and anesthetized chronically instrumented dogs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthesia; Anesthetics; Animals; Autonomic Nerve Block; Autonomic Nervous System; Calcium Channels; Consciousness; Diastole; Dihydropyridines; Dogs; Drug Interactions; Halothane; Hemodynamics; Isoflurane; Myocardial Contraction; Nifedipine; Systole; Ventricular Function, Left | 1994 |
Endogenous DHP-sensitive Ca(2+) channels in Pleurodeles oocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channels; Dihydropyridines; Membrane Potentials; Mollusk Venoms; Nifedipine; omega-Conotoxin GVIA; Oocytes; Peptides; Pleurodeles | 1994 |
Inhibition of dihydropyridine-sensitive calcium entry in hypoxic relaxation of airway smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bronchi; Calcium; Calcium Channel Blockers; Carbachol; Dihydropyridines; Female; Hypoxia; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Potassium Chloride; Swine | 1995 |
Single-channel properties of four calcium channel types in rat motoneurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium Channels; Dihydropyridines; Hypoglossal Nerve; Motor Neurons; Nerve Tissue Proteins; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Spider Venoms | 1995 |
Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. II. Modulation of high-voltage-activated calcium currents.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Cell Separation; Cerebral Cortex; Corpus Striatum; Dihydropyridines; Glutamates; Male; Neural Pathways; Nifedipine; Oxcarbazepine; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Presynaptic; Synaptic Transmission | 1995 |
Dihydropyridine-like effects of amiodarone and desethylamiodarone on thyrotropin secretion and intracellular calcium concentration in rat pituitary.
Topics: Amiodarone; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Drug Synergism; Male; Nifedipine; Peptide Fragments; Pituitary Gland; Protein Precursors; Rats; Rats, Wistar; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine | 1995 |
Block of non-L-, non-N-type Ca2+ channels in rat insulinoma RINm5F cells by omega-agatoxin IVA and omega-conotoxin MVIIC.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Stimulation; Insulinoma; Kinetics; Nifedipine; omega-Agatoxin IVA; omega-Conotoxins; Pancreatic Neoplasms; Peptides; Rats; Spider Venoms; Tumor Cells, Cultured | 1995 |
Effects of nifedipine and Bay-K-8644 on the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Anesthesia; Animals; Calcium Channels; Dihydropyridines; Dogs; Electric Stimulation; Epinephrine; Female; Male; Nifedipine; Norepinephrine; Sensitivity and Specificity; Splanchnic Nerves | 1993 |
Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Dihydropyridines; Electric Conductivity; Female; Ion Channel Gating; Kinetics; Macromolecular Substances; Myocardium; Nifedipine; Nisoldipine; Oocytes; Structure-Activity Relationship; Xenopus laevis | 1995 |
The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic AMP; Cycloleucine; Dihydropyridines; Glutamic Acid; GTP-Binding Proteins; Mice; Neurotoxins; Nifedipine; Pertussis Toxin; Protein Kinases; Receptors, Metabotropic Glutamate; Second Messenger Systems; Up-Regulation; Virulence Factors, Bordetella | 1994 |
Blockers of Ca2+ channels in the plasmalemma of perfused Characeae cells.
Topics: Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chlorophyta; Dihydropyridines; Membrane Potentials; Nifedipine; Nitrendipine; Perfusion; Pyridines | 1994 |
Calcitonin stimulates calcium transport in distal convoluted tubule cells.
Topics: Animals; Biological Transport; Calcitonin; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cycloheximide; Dihydropyridines; Dose-Response Relationship, Drug; Kidney Tubules, Distal; Membrane Potentials; Mice; Nifedipine; Parathyroid Hormone; Time Factors | 1993 |
Actions of 1,4-dihydropyridines in isolated mesenteric vascular beds.
Topics: Animals; Arginine; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Nifedipine; Nitrendipine; Nitric Oxide; Nitroarginine; Vasodilation | 1995 |
Heart period variability in patients with variant angina.
Topics: Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Electrocardiography, Ambulatory; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Nisoldipine; Sympathetic Nervous System | 1996 |
G proteins regulate dihydropyridine binding to moss plasma membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Binding Sites; Bryopsida; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; GTP-Binding Proteins; Guanine Nucleotides; Nifedipine | 1996 |
Activation of nucleotide receptors inhibits high-threshold calcium currents in NG108-15 neuronal hybrid cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine; Adenylyl Cyclases; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Hybrid Cells; Mice; Mollusk Venoms; Neuroblastoma; Neurons; Nifedipine; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Rats; Receptors, Cell Surface; Virulence Factors, Bordetella | 1996 |
Pharmacological analysis of voltage-dependent potassium currents in cultured skeletal myocytes of the frog Rana temporaria.
Topics: 4-Aminopyridine; Animals; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Electric Conductivity; Embryo, Nonmammalian; Membrane Potentials; Muscle, Skeletal; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rana temporaria; Time Factors; Verapamil | 1995 |
1,4-Dihydropyridines versus beta-blockers for hypertension: are either safe for the heart?
Topics: Adrenergic beta-Antagonists; Adult; Aged; Calcium Channel Blockers; Coronary Disease; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Sympathetic Nervous System | 1996 |
Sympathetic modulation of the effect of nifedipine on myocardial contraction and Ca current in the rat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Heart Ventricles; Hypertension; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardial Reperfusion; Nifedipine; Patch-Clamp Techniques; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Sympatholytics; Sympathomimetics; Ventricular Function | 1997 |
Venodilator effects of pranidipine, a 1,4-dihydropyridine Ca2+ channel antagonist, in rats: comparison with nifedipine and amlodipine.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Dihydropyridines; Injections, Intravenous; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Venous Pressure | 1997 |
Depolarization and activation of dihydropyridine-sensitive Ca2+ channels stimulate inositol phosphate accumulation in photoreceptor-enriched chick retinal cell cultures.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chick Embryo; Dihydropyridines; Electric Stimulation; Estrenes; Inositol Phosphates; Membrane Potentials; Nifedipine; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphodiesterase Inhibitors; Photoreceptor Cells; Potassium; Pyrrolidinones; Type C Phospholipases; Virulence Factors, Bordetella | 1997 |
Role of dihydropyridine sensitive calcium channels in glucose transport in skeletal muscle.
Topics: Animals; Biological Transport; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Stimulation; Glucose; Insulin; Male; Muscle Contraction; Muscle, Skeletal; Nifedipine; Rats; Rats, Sprague-Dawley | 1997 |
Osmo-mechanically sensitive phosphatidylinositol signaling regulates a Ca2+ influx channel in renal epithelial cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carbamates; Cells, Cultured; Dihydropyridines; Enzyme Inhibitors; Epithelium; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Nifedipine; Phenylcarbamates; Phosphatidylinositols; Rabbits; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Water-Electrolyte Balance | 1997 |
Endogenous pacemaker activity of rat tumour somatotrophs.
Topics: Action Potentials; Animals; Antisense Elements (Genetics); Apamin; Barium; Biological Clocks; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Charybdotoxin; Computer Simulation; Cytosol; Dihydropyridines; Growth Hormone; Growth Hormone-Releasing Hormone; Nickel; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Pituitary Neoplasms; Potassium; Rats; Ryanodine Receptor Calcium Release Channel; Sodium; Spider Venoms; Tetraethylammonium; Tetrodotoxin; Tumor Cells, Cultured | 1998 |
Voltage-gated calcium channels in Pleurodeles oocytes: classification, modulation and functional roles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Breeding; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Dihydropyridines; Electric Stimulation; Ion Channel Gating; Ion Transport; Meiosis; Membrane Potentials; Nickel; Nifedipine; omega-Conotoxin GVIA; Oocytes; Peptides; Phosphorylation; Pleurodeles; Progesterone; Protein Processing, Post-Translational; Seasons; Second Messenger Systems | 1998 |
Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthetics, Inhalation; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Halothane; Heart Ventricles; Isradipine; Myocardial Contraction; Myocardium; Nifedipine; Rats; Rats, Wistar; Sarcolemma; Verapamil | 1998 |
Passive transfer of Lambert-Eaton myasthenic syndrome induces dihydropyridine sensitivity of ICa in mouse motor nerve terminals.
Topics: Animals; Autoantibodies; Binding, Competitive; Calcium; Calcium Channel Blockers; Dihydropyridines; Immunization, Passive; Lambert-Eaton Myasthenic Syndrome; Male; Mice; Mice, Inbred ICR; Motor Neurons; Nifedipine; omega-Agatoxin IVA; omega-Conotoxins; Peptides; Plasma; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spider Venoms; Synaptosomes; Tetraethylammonium; Verapamil | 1998 |
Selective cardiodepressant activity of fluodipine, a fluorenone-1,4-dihydropyridine derivative.
Topics: Anesthesia; Animals; Aorta; Atrial Function; Binding, Competitive; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Dicarboxylic Acids; Dihydropyridines; Electrophysiology; Female; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Pacemaker, Artificial; Patch-Clamp Techniques; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sinoatrial Node; Vasoconstriction; Vasodilator Agents | 1998 |
Modulation of neurotransmitter release by dihydropyridine-sensitive calcium channels involves tyrosine phosphorylation.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Adhesion Molecules; Cerebellum; Dihydropyridines; Electrophysiology; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Membrane Potentials; Nerve Tissue Proteins; Nifedipine; omega-Conotoxins; Peptides; Phosphorylation; Potassium; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Time Factors; Tritium; Tyrosine; Vanadates; Vinculin | 1999 |
Effects of morphine in rats withdrawn from repeated nifedipine administration.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Calcium Channel Blockers; Catalepsy; Dihydropyridines; Dopamine; Drug Interactions; In Vitro Techniques; Male; Morphine; Nifedipine; Pain Measurement; Rats; Serotonin; Substance Withdrawal Syndrome; Time Factors | 1999 |
Regional expression and functional characterization of the L-type Ca2+-channel in myocardium from patients with end-stage heart failure and in non-failing human hearts.
Topics: Adolescent; Adult; Aged; Binding Sites; Blotting, Northern; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calsequestrin; Cardiomyopathy, Dilated; Dihydropyridines; Dose-Response Relationship, Drug; Female; Heart; Heart Failure; Humans; Male; Middle Aged; Myocardium; Nifedipine; Tissue Distribution | 1999 |
L-type calcium channels but not N-methyl-D-aspartate receptor channels mediate rhythmic activity induced by cholinergic agonist in motoneurons from turtle spinal cord slices.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cholinergic Fibers; Dihydropyridines; Excitatory Amino Acid Agonists; Magnesium; Motor Neurons; Muscarine; Muscarinic Agonists; N-Methylaspartate; Nicotinic Antagonists; Nifedipine; Organ Culture Techniques; Periodicity; Receptors, N-Methyl-D-Aspartate; Serotonin; Spinal Cord; Tetrodotoxin; Tubocurarine; Turtles | 1999 |
Effects of long-acting versus short-acting calcium channel blockers among older survivors of acute myocardial infarction.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Humans; Male; Myocardial Infarction; Nicardipine; Nifedipine; Proportional Hazards Models; Retrospective Studies; Risk; Survival Analysis; Survivors; Verapamil | 1999 |
Effects of L-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats.
Topics: Animals; Calcium Channel Blockers; Conditioning, Operant; Dihydropyridines; Discrimination Learning; Ethanol; Feeding Behavior; Isradipine; Male; Nifedipine; Rats; Taste | 1999 |
Volume regulatory decrease in UMR-106.01 cells is mediated by specific alpha1 subunits of L-type calcium channels.
Topics: Animals; Bone Neoplasms; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Size; Dihydropyridines; Hypotonic Solutions; Nifedipine; Oligonucleotides, Antisense; Osmolar Concentration; Osteoblasts; Osteosarcoma; Patch-Clamp Techniques; Protein Isoforms; Rats; Tumor Cells, Cultured | 1999 |
Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Coronary Circulation; Dihydropyridines; Heart Atria; Heart Block; Heart Rate; Isradipine; Male; Myocardial Contraction; Nifedipine; Pyridines; Rats; Rats, Sprague-Dawley; Systole; Ventricular Function, Left; Ventricular Pressure | 1999 |
Calcium channel activation and self-biting in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aggression; Animals; Behavior, Animal; Bites and Stings; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Diltiazem; Ion Channel Gating; Mice; Mice, Inbred C57BL; Nifedipine; Nimodipine; Nitrendipine; Pyrroles; Self-Injurious Behavior | 1999 |
Arterial responses in vitro and plasma digoxin immunoreactivity after losartan and enalapril treatments in experimental hypertension.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Cardiomegaly; Digoxin; Dihydropyridines; Enalapril; Heart; Hypertension; Losartan; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Organ Size; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium-Potassium-Exchanging ATPase; Tunica Media | 2000 |
Characterization of calcium-mobilizing, purinergic P2Y(2) receptors in human ovarian cancer cells.
Topics: Adenosine Triphosphate; Calcium; Calcium Channel Blockers; Cell Division; Dihydropyridines; Enzyme Activation; Enzyme Inhibitors; Female; Glycerophospholipids; Humans; Nifedipine; Ovarian Neoplasms; Phospholipase D; Potassium; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Thapsigargin; Tumor Cells, Cultured; Uridine Triphosphate | 2000 |
Mibefradil, an I(Ca,T) blocker, effectively blocks I(Ca,L) in rabbit sinus node cells.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Female; Mibefradil; Nifedipine; Rabbits; Sinoatrial Node | 2000 |
Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons.
Topics: Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cerebellum; Cyclic AMP Response Element-Binding Protein; Dihydropyridines; Genes, Dominant; Mice; Models, Biological; Mutation; Neurons; Neuroprotective Agents; Nifedipine; Phosphorylation; Potassium; Protein Processing, Post-Translational | 2001 |
Gadolinium prevents stretch-mediated contractile dysfunction in isolated papillary muscles.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Gadolinium; Guinea Pigs; Heart Failure; Hypoxia; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Nifedipine; Oxygen; Papillary Muscles | 2001 |
Activation of purified cardiac ryanodine receptors by dihydropyridine agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Dogs; Membrane Potentials; Myocardium; Nicotinic Acids; Nifedipine; Oxadiazoles; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Stereoisomerism | 2001 |
Chronic nicotine alters NO signaling of Ca(2+) channels in cerebral arterioles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arterioles; Barium; Calcium; Calcium Channels; Calcium Channels, L-Type; Cerebral Arteries; Cerebrovascular Circulation; Cyclic GMP; Dihydropyridines; Electric Stimulation; Female; Membrane Potentials; Muscle, Smooth, Vascular; Nicotine; Nifedipine; Nitric Oxide; Nitroprusside; Potassium Channels; Rats; Rats, Inbred WKY; Signal Transduction; Time Factors; Tyrphostins | 2001 |
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Cytosol; Dihydropyridines; Diltiazem; Egtazic Acid; Gadolinium; Hydrogen Peroxide; Isradipine; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Lanthanum; Nifedipine; Protamines; Rats; Rats, Sprague-Dawley; Thapsigargin; Verapamil | 2001 |
Dihydropyridine calcium channel blockers and peripheral side effects.
Topics: Calcium Channel Blockers; Dihydropyridines; Edema; Erythema; Exanthema; Humans; Hyperpigmentation; Hypertension; Male; Middle Aged; Nifedipine | 2001 |
Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 6-Ketoprostaglandin F1 alpha; Anesthesia; Animals; Aorta; Blood Pressure; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cardiac Output; Consciousness; Dihydropyridines; Female; Heart Rate; Muscle, Smooth, Vascular; Nifedipine; Pregnancy; Pregnancy, Animal; Rabbits; Thromboxane B2; Tritium | 2002 |
Decoration of dihydropyrimidine and dihydropyridine scaffolds with sugars via Biginelli and Hantzsch multicomponent reactions: an efficient entry to a collection of artificial nucleosides.
Topics: Carbohydrates; Dihydropyridines; Glycosylation; Nifedipine; Nucleosides; Pyrimidines; Stereoisomerism; Thiones | 2003 |
MRS study of the interaction of dihydropyridines with lipid molecules in phosphatidylcholine vesicles.
Topics: Dihydropyridines; Dimyristoylphosphatidylcholine; Lipid Metabolism; Lipids; Liposomes; Magnetic Resonance Spectroscopy; Molecular Structure; Nifedipine | 2003 |
Case studies in hypertension. Dihydropyridine/nondihydropyridine calcium channel blocker combination therapy.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Female; Humans; Hypertension; Lisinopril; Male; Middle Aged; Nifedipine; Verapamil | 2005 |
Emergence of a R-type Ca2+ channel (CaV 2.3) contributes to cerebral artery constriction after subarachnoid hemorrhage.
Topics: Animals; Blood; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, R-Type; Cerebral Arteries; Cisterna Magna; Dihydropyridines; Diltiazem; Disease Models, Animal; Drug Resistance; Injections; Ion Transport; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Rabbits; Spider Venoms; Subarachnoid Hemorrhage; Vasoconstriction; Vasospasm, Intracranial | 2005 |
1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Female; Flavones; Guinea Pigs; Heart Atria; Nifedipine; Vasodilator Agents | 2005 |
The L-type calcium channel blockers, hantzsch 1,4-dihydropyridines, are not peroxyl radical-trapping, chain-breaking antioxidants.
Topics: Acridines; Antioxidants; Benzene Derivatives; Biphenyl Compounds; Calcium Channel Blockers; Calcium Channels, L-Type; Chromans; Dihydropyridines; Free Radicals; Hydrazines; Kinetics; Nifedipine; Nimodipine; Oxidation-Reduction; Peroxides; Picrates; Styrene | 2006 |
Design, synthesis, and calcium channel antagonist activity of new 1,4-dihydropyridines containing 4-(5)-chloro-2-ethyl-5-(4)-imidazolyl substituent.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Drug Design; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Male; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Nifedipine; Structure-Activity Relationship | 2006 |
The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.
Topics: Calcium Channel Blockers; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Gamma Rays; Humans; Hypertension; Models, Molecular; Molecular Conformation; Myocardial Ischemia; Nifedipine; Nimodipine | 2007 |
Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker.
Topics: Administration, Oral; Amines; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Cyclohexanecarboxylic Acids; Dihydropyridines; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Models, Animal; Nifedipine; omega-Conotoxins; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2009 |
Flutamide inhibits nifedipine- and interleukin-1 beta-induced collagen overproduction in gingival fibroblasts.
Topics: Androgen Antagonists; Calcium Channel Blockers; Case-Control Studies; Cell Culture Techniques; Cells, Cultured; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Connective Tissue Growth Factor; Culture Media, Conditioned; Dihydropyridines; Drug Synergism; Female; Fibroblasts; Flutamide; Gingiva; Gingival Overgrowth; Humans; Interleukin-1beta; Male; Middle Aged; Nifedipine; Receptors, Androgen; Time Factors | 2010 |
Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Dicarboxylic Acids; Dihydropyridines; Humans; Inhibitory Concentration 50; Molecular Structure; Nifedipine | 2010 |
Facile and efficient aromatization of 1,4-dihydropyridines with M(NO3)2.XH2O, TNCB, TBAP and HMTAI and preparation of deuterium labeled dehydronifedipine from nifedipine-d3.
Topics: Calcium Channel Blockers; Deuterium; Dihydropyridines; Humans; Metals; Methenamine; Nifedipine; Nitrates; Quaternary Ammonium Compounds; Radiopharmaceuticals; Vasodilator Agents | 2010 |
Calcium inhibits dihydropyridine-stimulated increases in opening and unitary conductance of a plant Ca²+ channel.
Topics: Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Lipid Bilayers; Membrane Potentials; Membranes, Artificial; Nicotinic Acids; Nifedipine; Oxadiazoles; Plant Roots; Triticum | 2011 |
New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cations; Cell Line; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Kidney; Membrane Potentials; Nifedipine | 2011 |
How do dihydropyridine and nondihydropyridine CCBs differ?
Topics: Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Heart Conduction System; Humans; Nifedipine | 2012 |
Nitric oxide inhibits androgen receptor-mediated collagen production in human gingival fibroblasts.
Topics: Aged; Case-Control Studies; Cells, Cultured; Collagen Type I; Dihydropyridines; Fibroblasts; Gingiva; Gingival Overgrowth; Humans; Interleukin-1beta; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase Type II; Receptors, Androgen; Statistics, Nonparametric | 2012 |
Benidipine persistently inhibits delayed rectifier K(+)-channel currents in murine thymocytes.
Topics: Animals; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Kv1.3 Potassium Channel; Male; Membrane Potentials; Mice; Nifedipine; Thymocytes | 2013 |
Repetition priming-induced changes in sensorimotor transmission.
Topics: Action Potentials; Animals; Aplysia; Calcium; Calcium Channel Blockers; Dihydropyridines; Ganglia, Invertebrate; Long-Term Potentiation; Motor Neurons; Neurons, Afferent; Neuropeptides; Nifedipine; Repetition Priming; Synaptic Transmission | 2016 |
Synthesis, Evaluation of Pharmacological Activity, and Molecular Docking of 1,4-Dihydropyridines as Calcium Antagonists.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Male; Molecular Docking Simulation; Nifedipine; Proton Magnetic Resonance Spectroscopy | 2016 |
In search of the mutual relationship between the structure, solid-state spectroscopy and molecular dynamics in selected calcium channel blockers.
Topics: Calcium Channel Blockers; Crystallization; Dihydropyridines; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Nifedipine; Nimodipine; Nitrendipine; Quantum Theory; Spectrophotometry, Infrared; X-Ray Diffraction | 2016 |
Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock.
Topics: Animals; Blood Glucose; Blood Pressure; Bradycardia; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Fat Emulsions, Intravenous; Female; Heart Arrest, Induced; Humans; Metabolome; Myocardial Contraction; Nifedipine; Pilot Projects; Shock; Swine; Tachycardia | 2016 |
Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization.
Topics: Calcium Channel Blockers; Crystallization; Dihydropyridines; Molecular Conformation; Niacinamide; Nifedipine; Oxidation-Reduction; Photochemical Processes; Thermodynamics | 2017 |