nifedipine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

nifedipine has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.82)	18.7374
1990's	22 (40.00)	18.2507
2000's	18 (32.73)	29.6817
2010's	14 (25.45)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Castrén, E; Hartikka, J; Lindholm, D; Thoenen, H; Zafra, F	1
Obara, K; Usuki, T; Yabu, H	1
Baux, G; Fossier, P; Tauc, L; Trudeau, LE	1
Glembotski, CC; Hidaka, H; Irons, CE; Sei, CA	1
Ito, K; Nishimura, K; Ota, M	1
Del Bianco, E; Geppetti, P; Maggi, CA; Patacchini, R; Santicioli, P; Tramontana, M	1
Brown, JH; Glembotski, CC; Irons, CE; McDonough, PM; Sei, CA; Sprenkle, AB	1
Endou, M; Hattori, Y; Kanno, M; Nakaya, H	1
Russell, JA; Steffan, M	1
Albitz, R; Franke, T; Markwardt, F; Nilius, B	1
Kurtz, A; Scholz, H	1
Dandona, P; Jeremy, JY	1
Chik, CL; Ho, AK; Karpinski, E; Li, B; Liu, QY	1
Dreijer, AM; Kits, KS	1
Ito, K; Sasaki, Y; Seto, M; Shindo, K	1
Nishio, A; Sakaguchi, H	1
Andersson, KE; Garcia-Pascual, A; Holmquist, F; Persson, K	1
Clark, AH; Garland, CJ	1
Chang, JP; Jobin, RM; Neumann, CM	1
McCullough, LA; Westfall, TC	1
Kachar, B; Lacaz-Vieira, F	1
Gault, LM; Siegel, RE	1
Funakoshi, M; Horiguchi, S; Karibe, A; Katoh, H; Keitoku, M; Satoh, S; Shirato, K; Suzuki, S; Takeuchi, M; Watanabe, J	1
Ikegaki, I; Sasaki, Y; Uchida, T; Yamamoto, Y	1
Blandizzi, C; Colucci, R; Del Tacca, M; Tognetti, M	1
Fukushi, H; Morishima, Y; Shirasaki, Y; Takano, H	1
Bigdai, EV; Samoilov, VO	1
Bauer, J; Parekh, N	1
Carlson, RR; Dudman, JT; Konradi, C; Macías, W	1
Barnes, BR; Craig, BW; Fick, CA; Lim, K; Olesen, JB; Wright, DC	1
Fu, XZ; Meng, FJ; Zhang, GY; Zhang, QG	1
Hackman, JC; Holohean, AM	1
Kim, W; Lee, CJ; Nam, RH	1
Arikan, O; Ark, M; Büyükafsar, K; Korkmaz, B; Kubat, H; Ozveren, E; Songu-Mize, E; Yazici, G	1
Kalil, K; Tang, F	1
Guan, QH; Hao, ZB; Pei, DS; Zhang, GY	1
Blishchenko, EY; Ivanov, VT; Karelin, AA; Khachin, DP; Leontiev, KV; Sazonova, OV; Tolmazova, AG	1
Archer, SL; Bonnet, SN; Haromy, A; Harry, G; Hashimoto, K; Kajimoto, H; Michelakis, ED; Moudgil, R; Nakanishi, T; Rebeyka, I; Thébaud, B	1
Kudo, T; Murakami, I; Sutou, S; Takahashi, S; Takeuchi, S	1
Jin, L; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z	1
Mody, I; Sokolova, IV	1
Balezina, OP; Bogatcheva, PO; Ezhova, EV	1
Bednarek, ML; Miner, AS; Ratz, PH; Speich, JE	1
Greenwood, JA; Ma, L; Schachner, M	1
Hein, TW; Kuo, E; Kuo, L; Lu, G; Ngo, E; Potts, LB; Ren, Y	1
Fan, YF; Fang, HC; Su, YS; Xie, PY; Zhang, ZJ; Zhang, ZY	1
Behuliak, M; Bencze, M; Karen, P; Kuneš, J; Líšková, S; Petrová, M; Pintérová, M; Vaněčková, I; Zicha, J	1
Calderón-Sánchez, E; González-Rodríguez, P; López-Barneo, J; Porras-González, C; Ureña, J	1
Chebolu, S; Darmani, NA; Hutchinson, TE; Wilson, SM; Zhong, W	1
Castellano, A; Egea-Guerrero, JJ; González-Montelongo, Mdel C; Muñoz-Sánchez, MÁ; Murillo-Cabezas, F; Porras-González, C; Ureña, J; Vilches-Arenas, A	1
Dzialowski, EM; Greyner, H	1
Behuliak, M; Bencze, M; Ergang, P; Kuneš, J; Polgárová, K; Vaněčková, I; Vavřínová, A; Zicha, J	1
Hishinuma, E; Ishida, H; Ishikawa, T; Kitayama, T; Saito, SY	1
Behuliak, M; Hojná, S; Kadlecová, M; Kopkan, L; Vaněčková, I; Zicha, J	1

Other Studies

55 other study(ies) available for nifedipine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine

Article	Year
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytokines; Glutamates; Glutamic Acid; Growth Substances; Hippocampus; Ionomycin; Isoquinolines; Kainic Acid; Kinetics; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Nifedipine; Norepinephrine; Piperazines; Potassium; Protein Kinase Inhibitors; Quisqualic Acid; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate	1992
Calcium and potassium channel regulation by protein phosphorylation in smooth muscle cells of guinea pig taenia coli. Advances in experimental medicine and biology, 1992, Volume: 311 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Atropine; Calcium Channels; Carbachol; Colon; Guinea Pigs; In Vitro Techniques; Isoquinolines; Marine Toxins; Membrane Potentials; Models, Biological; Muscle, Smooth; Nifedipine; Oxazoles; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Potassium Channels; Protein Kinase C	1992
Pre- and postsynaptic actions of nifedipine at an identified cholinergic central synapse of Aplysia. Pflugers Archiv : European journal of physiology, 1992, Volume: 422, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aplysia; Calcium; Cheek; Electric Conductivity; Ganglia, Parasympathetic; Isoquinolines; Neurotransmitter Agents; Nifedipine; Piperazines; Protein Kinase Inhibitors; Synapses	1992
Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes. The Journal of biological chemistry, 1992, Mar-15, Volume: 267, Issue:8 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Natriuretic Factor; Cells, Cultured; Endothelins; Heart; Heart Atria; Isoquinolines; Kinetics; Myocardium; Nifedipine; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Sulfonamides	1992
Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation. British journal of pharmacology, 1991, Volume: 102, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Carbamates; Cromakalim; In Vitro Techniques; Isoquinolines; Lanthanum; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phenylcarbamates; Phenylephrine; Phosphatidylinositols; Piperazines; Protease Inhibitors; Pyrroles; Rats	1991
Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: mechanism of action and biological response. Neuroscience, 1991, Volume: 41, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acids; Animals; Calcitonin Gene-Related Peptide; Calcium Channels; Capsaicin; Guinea Pigs; Hydrogen-Ion Concentration; Indomethacin; Isoquinolines; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Neurosecretion; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperazines; Potassium; Ruthenium Red; Tetrodotoxin; Urinary Bladder	1991
The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways. The Journal of biological chemistry, 1991, Aug-25, Volume: 266, Issue:24 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Atrial Natriuretic Factor; Calcium; Calmodulin; Cells, Cultured; Gene Expression; Heart; Hydrolysis; Isoquinolines; Myocardium; Nifedipine; Phenylephrine; Phosphatidylinositols; Piperazines; Protein Kinase C; Rats; Sulfonamides	1991
Pharmacological analysis of the positive inotropic effect of endothelin-1 in guinea pig left atria. Journal of cardiovascular pharmacology, 1991, Volume: 17 Suppl 7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atrial Function; Electric Stimulation; Endothelins; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Inositol; Isoquinolines; Male; Myocardial Contraction; Myocardium; Nifedipine; Phosphatidylinositols; Piperazines; Staurosporine; Stimulation, Chemical	1991
Signal transduction in endothelin-induced contraction of rabbit pulmonary vein. Pulmonary pharmacology, 1990, Volume: 3, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Endothelins; In Vitro Techniques; Isoquinolines; Nifedipine; Norepinephrine; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Pulmonary Veins; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Vasoconstrictor Agents; Verapamil	1990
Effects of thrombin on single calcium channels in frog ventricular cells. Pflugers Archiv : European journal of physiology, 1990, Volume: 415, Issue:5 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channels; Electrophysiology; Heart Ventricles; Isoquinolines; Kinetics; Myocardium; Nifedipine; Piperazines; Protein Kinase Inhibitors; Rana esculenta; Thrombin; Time Factors	1990
Role of protein kinase C in renal vasoconstriction caused by angiotensin II. The American journal of physiology, 1990, Volume: 259, Issue:3 Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Cobalt; Enzyme Inhibitors; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil	1990
Fluoride but not phorbol esters stimulate rat urinary bladder prostanoid synthesis: investigations into the roles of G proteins and protein kinase C. Prostaglandins, leukotrienes, and medicine, 1987, Volume: 29, Issue:2-3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atropine; Bucladesine; Calcimycin; Carbachol; Fluorides; GTP-Binding Proteins; Isoquinolines; Nifedipine; Phorbol Esters; Piperazines; Prostaglandins; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Urinary Bladder; Verapamil	1987
cGMP inhibits L-type Ca2+ channel currents through protein phosphorylation in rat pinealocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Isoquinolines; Male; Nifedipine; Nitroprusside; Norepinephrine; Patch-Clamp Techniques; Phosphorylation; Pineal Gland; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thionucleotides	1995
Multiple second messenger routes enhance two high-voltage-activated calcium currents in molluscan neuroendocrine cells. Neuroscience, 1995, Volume: 64, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channels; Cyclic AMP; Cyclic GMP; Electrophysiology; Isoquinolines; Lymnaea; Neurosecretory Systems; Nifedipine; omega-Conotoxin GVIA; Peptides; Phosphorylation; Piperazines; Protein Kinase C; Second Messenger Systems; Thionucleotides; Verapamil	1995
Selective inhibition of myosin phosphorylation and tension of hyperplastic arteries by the kinase inhibitor HA1077. European journal of pharmacology, 1995, Mar-24, Volume: 276, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carotid Arteries; Hyperplasia; In Vitro Techniques; Isoquinolines; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Myosins; Nifedipine; Phosphorylation; Potassium; Rabbits; Vasoconstriction	1995
Mechanisms of the enhanced contractile response to phenylephrine in thoracic aorta isolated from rats with dietary magnesium deficiency. Japanese journal of pharmacology, 1994, Volume: 64, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Diet; In Vitro Techniques; Isoquinolines; Isradipine; Magnesium Deficiency; Male; Nifedipine; Phenylephrine; Piperazines; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction	1994
Endothelin-1-induced phosphoinositide hydrolysis and contraction in isolated rabbit detrusor and urethral smooth muscle. General pharmacology, 1993, Volume: 24, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Endothelins; Female; Hydrolysis; In Vitro Techniques; Isoquinolines; Muscle Contraction; Muscle, Smooth; Nickel; Nifedipine; Phosphatidylinositols; Piperazines; Protein Kinase Inhibitors; Rabbits; Urethra; Urinary Bladder	1993
Ca2+ channel antagonists and inhibition of protein kinase C each block contraction but not depolarization to 5-hydroxytryptamine in the rabbit basilar artery. European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium Channel Blockers; Carbamates; Female; Isoquinolines; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylcarbamates; Piperazines; Potassium; Protein Kinase C; Rabbits; Serotonin; Type C Phospholipases; Verapamil	1993
Roles of calcium and calmodulin in the mediation of acute and sustained GnRH-stimulated gonadotropin secretion from dispersed goldfish pituitary cells. General and comparative endocrinology, 1996, Volume: 101, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Cobalt; Culture Media; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Pituitary Gland	1996
Mechanism of catecholamine synthesis inhibition by neuropeptide Y: role of Ca2+ channels and protein kinases. Journal of neurochemistry, 1996, Volume: 67, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenine; Animals; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Catecholamines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; Imidazoles; Ion Channel Gating; Isoquinolines; Neuropeptide Y; Nifedipine; omega-Conotoxin GVIA; PC12 Cells; Peptides; Piperazines; Protein Kinase C; Protein Kinases; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate; Thionucleotides	1996
Tight junction dynamics in the frog urinary bladder. Cell adhesion and communication, 1996, Volume: 4, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Barium Sulfate; Cadherins; Cadmium; Calcium; Calcium Channel Blockers; Cell Polarity; Diglycerides; Enzyme Inhibitors; Freeze Fracturing; Magnesium; Nifedipine; Osmotic Pressure; Patch-Clamp Techniques; Protein Kinase C; Rana catesbeiana; Signal Transduction; Tight Junctions; Urinary Bladder; Verapamil	1996
Expression of the GABAA receptor delta subunit is selectively modulated by depolarization in cultured rat cerebellar granule neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Apr-01, Volume: 17, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Chelating Agents; Culture Media, Serum-Free; Enzyme Inhibitors; Gene Expression Regulation; Isoquinolines; Kinetics; Macromolecular Substances; Membrane Potentials; Neurons; Nifedipine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Sulfonamides; Tetrodotoxin; Time Factors; Transcription, Genetic	1997
Role of cytosolic Ca2+ and protein kinase C in developing myogenic contraction in isolated rat small arteries. The American journal of physiology, 1997, Volume: 272, Issue:3 Pt 2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium; Cytosol; Femoral Artery; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth, Vascular; Nifedipine; Protein Kinase C; Rats; Rats, Wistar; Second Messenger Systems; Staurosporine	1997
The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit. Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Movement; Diltiazem; Electrocardiography; Endothelin-1; Enzyme Inhibitors; Heart Ventricles; Macrophages; Male; Microscopy; Myocardial Ischemia; Necrosis; Neutrophils; Nicorandil; Nifedipine; Papillary Muscles; Rabbits; Random Allocation; Vasodilator Agents	2000
Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves. British journal of pharmacology, 2000, Volume: 129, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Calcium; Colforsin; Dose-Response Relationship, Drug; Ethylmaleimide; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; Ileum; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Muscle, Smooth; Myenteric Plexus; Nifedipine; Norepinephrine; omega-Conotoxins; Pertussis Toxin; Phenols; Receptors, Histamine H3; Rolipram; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetrodotoxin; Virulence Factors, Bordetella; Yohimbine	2000
Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization. Brain research, 2003, Feb-07, Volume: 962, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Death; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Enzyme Inhibitors; Fetus; Kinetics; Membrane Potentials; Neurons; NG-Nitroarginine Methyl Ester; Nifedipine; Nitriles; Pyrethrins; Rats; Sulfonamides; Tacrolimus; Trifluoperazine; Veratridine	2003
Components of the intracellular cAMP system supporting the olfactory reception of amyl alcohol. Neuroscience and behavioral physiology, 2003, Volume: 33, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Aluminum Compounds; Animals; Antimetabolites; Caffeine; Calcium Channel Blockers; Calcium Chloride; Chelating Agents; Chlortetracycline; Colforsin; Cyclic AMP; Dideoxyadenosine; Egtazic Acid; Fluorides; In Vitro Techniques; Ionomycin; Ionophores; Microscopy, Fluorescence; Nifedipine; Olfactory Mucosa; Pentanols; Phosphodiesterase Inhibitors; Rana temporaria; Reaction Time; Signal Transduction; Smell	2003
Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat. Kidney international, 2003, Volume: 63, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Enzyme Inhibitors; Female; Gallic Acid; Indoles; Nifedipine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Renal Circulation; Signal Transduction; Staurosporine; Vasoconstrictor Agents	2003
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways. Brain research. Molecular brain research, 2003, Jul-23, Volume: 115, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antihypertensive Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Drug Interactions; Embryo, Mammalian; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Isoquinolines; Neurons; Nifedipine; Protein Precursors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection	2003
A role for calcium/calmodulin kinase in insulin stimulated glucose transport. Life sciences, 2004, Jan-02, Volume: 74, Issue:7 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Monosaccharide Transport Proteins; Muscle, Skeletal; Nifedipine; Phosphorylation; Rats; Rats, Sprague-Dawley	2004
NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia. Neuroscience research, 2004, Volume: 48, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Blotting, Western; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Densitometry; Dopamine Antagonists; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia-Ischemia, Brain; Male; Nifedipine; Phosphorylation; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Serine; Synaptosomes; Time Factors; Trifluoperazine	2004
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. British journal of pharmacology, 2004, Volume: 143, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ergolines; Excitatory Amino Acid Antagonists; Gallopamil; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Indoles; Magnesium; Memantine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nifedipine; Protein Kinase C; Pyridines; Rana pipiens; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Staurosporine; Sulfonamides; Tetrodotoxin	2004
NMDA receptor-dependent long-term potentiation in the telencephalon of the zebrafish. Neuroscience letters, 2004, Nov-11, Volume: 370, Issue:2-3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Long-Term Potentiation; Magnesium; Nifedipine; Potassium Chloride; Receptors, N-Methyl-D-Aspartate; Telencephalon; Time Factors; Valine; Zebrafish	2004
Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery. Cell biochemistry and biophysics, 2004, Volume: 41, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Biophysics; Calcium; Dose-Response Relationship, Drug; Humans; Models, Biological; Nifedipine; Potassium Chloride; Protein Isoforms; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Serotonin; Umbilical Arteries	2004
Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jul-13, Volume: 25, Issue:28 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Butadienes; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Chickens; Cricetinae; Cytoskeleton; Dantrolene; Flavonoids; Growth Cones; MAP Kinase Signaling System; Mesocricetus; Nerve Growth Factors; Neurons; Nifedipine; Nitriles; Peptides; Protein Kinase Inhibitors; Recombinant Fusion Proteins; Ryanodine Receptor Calcium Release Channel; Transfection; Tumor Suppressor Proteins	2005
Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus. Brain research. Molecular brain research, 2005, Oct-31, Volume: 140, Issue:1-2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Brain Ischemia; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; GluK2 Kainate Receptor; Hippocampus; Male; Nifedipine; Phosphorylation; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Reperfusion	2005
Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK. The FEBS journal, 2007, Volume: 274, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Proliferation; Chelating Agents; Chlorocebus aethiops; Endorphins; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Isoquinolines; MAP Kinase Signaling System; Mice; Nifedipine; Protein Kinase Inhibitors; Sulfonamides; Verapamil	2007
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation, 2007, Apr-03, Volume: 115, Issue:13 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Ductus Arteriosus; Enzyme Activation; Enzyme Induction; Feedback, Physiological; Female; Fetal Heart; Gestational Age; Humans; Hydrogen Peroxide; Hypoplastic Left Heart Syndrome; Infant, Newborn; Intracellular Signaling Peptides and Proteins; Male; Mitochondria, Heart; Nifedipine; Organ Culture Techniques; Oxidation-Reduction; Oxygen; Partial Pressure; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Reactive Oxygen Species; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Superoxides; Vasoconstriction	2007
Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter. The Journal of endocrinology, 2007, Volume: 193, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Corticotropin-Releasing Hormone; Cyclic AMP; Dexamethasone; Gene Deletion; Gene Expression Regulation; Glucocorticoids; Homeodomain Proteins; Nifedipine; Paired Box Transcription Factors; Pro-Opiomelanocortin; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; T-Box Domain Proteins; Transfection	2007
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract. Biochemical pharmacology, 2007, Aug-15, Volume: 74, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Atropine; Blotting, Western; Calcium Signaling; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Enzyme Inhibitors; Guanine Nucleotide Dissociation Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rho-Specific Guanine Nucleotide Dissociation Inhibitors; rhoA GTP-Binding Protein; Urethra; Urinary Bladder	2007
Silencing-induced metaplasticity in hippocampal cultured neurons. Journal of neurophysiology, 2008, Volume: 100, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Analysis of Variance; Animals; Calcium Channel Blockers; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; Mice; Mice, Inbred C57BL; Neural Inhibition; Neuronal Plasticity; Neurons; Nifedipine; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Valine	2008
Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels. Bulletin of experimental biology and medicine, 2010, Volume: 149, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Animals; Benzophenanthridines; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinases; Excitatory Postsynaptic Potentials; Imidazoles; Indoles; Maleimides; Mice; Muscle, Skeletal; Nifedipine; Potassium Channels, Voltage-Gated; Protein Kinase C; Synapses	2010
Active tension adaptation at a shortened arterial muscle length: inhibition by cytochalasin-D. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:4 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Calcium Channels; Cytochalasin D; Femoral Artery; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Myosin Light Chains; Nifedipine; Phosphorylation; Potassium Chloride; Rabbits; rho-Associated Kinases; Thiazolidines	2011
CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chelating Agents; Chlorocebus aethiops; CREB-Binding Protein; Cystatins; Dendrites; Egtazic Acid; Embryo, Mammalian; Enzyme Inhibitors; Female; Green Fluorescent Proteins; Growth Cones; Hippocampus; Male; Microscopy, Confocal; Neurites; Neurons; Nifedipine; Potassium Chloride; Pseudopodia; Rats; RNA, Messenger; RNA, Small Interfering; Transfection; Up-Regulation; Valine	2011
Constriction of retinal arterioles to endothelin-1: requisite role of rho kinase independent of protein kinase C and L-type calcium channels. Investigative ophthalmology & visual science, 2012, May-17, Volume: 53, Issue:6 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterioles; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Endothelin-1; Endothelium, Vascular; Immunohistochemistry; Indoles; Maleimides; Nifedipine; Protein Isoforms; Protein Kinase C; Regional Blood Flow; Retinal Artery; rho-Associated Kinases; Swine; Vasoconstriction	2012
[Effects of rho-kinase inhibitor on cardiac hypertrophy of left ventricle in spontaneously hypertensive rats]. Zhonghua yi xue za zhi, 2012, Dec-25, Volume: 92, Issue:48 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cardiomegaly; Heart Ventricles; Male; Nifedipine; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; RNA, Messenger	2012
Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats. Journal of hypertension, 2013, Volume: 31, Issue:10 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Male; Mesenteric Arteries; Nifedipine; Nitric Oxide; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic; rho-Associated Kinases; rhoA GTP-Binding Protein; Temperature; Vasoconstriction	2013
Low-dose combination of Rho kinase and L-type Ca(2+) channel antagonists for selective inhibition of depolarization-induced sustained arterial contraction. European journal of pharmacology, 2014, Jun-05, Volume: 732 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; In Vitro Techniques; Male; Muscle Contraction; Myocytes, Cardiac; Myocytes, Smooth Muscle; Nifedipine; Patch-Clamp Techniques; Rats; Rats, Wistar; rho-Associated Kinases; Vasodilator Agents	2014
L-type calcium channels contribute to 5-HT3-receptor-evoked CaMKIIα and ERK activation and induction of emesis in the least shrew (Cryptotis parva). European journal of pharmacology, 2015, May-15, Volume: 755 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Stem; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Female; Male; Nifedipine; Receptors, Serotonin, 5-HT3; Serotonin; Shrews; Vomiting	2015
Role of L-type Ca(2+) channels, sarcoplasmic reticulum and Rho kinase in rat basilar artery contractile properties in a new model of subarachnoid hemorrhage. Vascular pharmacology, 2015, Volume: 72 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basilar Artery; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Sarcoplasmic Reticulum; Subarachnoid Hemorrhage; Vasoconstriction	2015
In vitro oxygen exposure promotes maturation of the oxygen sensitive contraction in pre-term chicken ductus arteriosus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2015, Volume: 188 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Chick Embryo; Chickens; Dinoprostone; Dose-Response Relationship, Drug; Ductus Arteriosus; Enzyme Inhibitors; Nifedipine; Nitric Oxide; Oxygen; Pyridines; rho-Associated Kinases; Time Factors; Vasoconstriction	2015
Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar-Kyoto and spontaneously hypertensive rats. Journal of hypertension, 2015, Volume: 33, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arteries; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Gene Expression; Guanine Nucleotide Exchange Factors; Hypertension; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Nifedipine; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction	2015
Differential contribution of calcium channels to α European journal of pharmacology, 2018, May-05, Volume: 826 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Body Temperature Regulation; Calcium; Calcium Channel Blockers; Calcium Channels; Cold Temperature; Iliac Artery; Large-Conductance Calcium-Activated Potassium Channels; Male; Models, Animal; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Phosphorylation; Protein Phosphatase 1; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction; Vasoconstriction	2018
Exaggerated blood pressure response to fasudil or nifedipine in hypertensive Ren-2 transgenic rats: role of altered baroreflex. Hypertension research : official journal of the Japanese Society of Hypertension, 2019, Volume: 42, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Baroreflex; Blood Pressure; Calcium Channel Blockers; Hypertension; Male; Nifedipine; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin-Angiotensin System; Vasoconstriction	2019