Page last updated: 2024-08-26

nicotine and warfarin

nicotine has been researched along with warfarin in 47 studies

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19907 (14.89)18.7374
1990's1 (2.13)18.2507
2000's21 (44.68)29.6817
2010's17 (36.17)24.3611
2020's1 (2.13)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Topliss, JG; Yoshida, F1
Caron, G; Ermondi, G1
Jolivette, LJ; Ward, KW1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Carrupt, PA; Martel, S; Ottaviani, G1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Majewski, F1
Vorherr, H1
Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G; Miller, DR1
Kasperbauer, MJ; Sorokin, TP; Tso, TC1
Elmenhorst, H; Goertz, E; Stadler, L1
Levy, G1
Inoue, K; Shimada, T; Yamazaki, H1
Cloak, CC; Lin, KM; Nuccio, I; Pechnick, RN; Poland, RE; Wan, YJ1
Aygün Kocabaş, N; Cholerton, S; Cok, I; Karakaya, AE; Sardaş, S1
Berthou, F; Dréano, Y; Le Gal, A; Lucas, D1
Cashman, JR; Fandrick, K; MacDougall, JM; Serafin, SV; Zhang, X1
DEWEY, LJ; STEPKA, W1
Fujieda, M; Kamataki, T; Kiyotani, K; Peamkrasatam, S; Sriwatanakul, K; Yamazaki, H; Yoovathaworn, K1
Higashi, E; Katoh, M; Nakajima, M; Tokudome, S; Yokoi, T1
Brown, SA1
Ashton, M; Asimus, S; Hai, TN; Van Huong, N1
Anzenbacher, P; Otyepka, M; Skopalík, J1
Bultinck, P; Van Damme, S1
Choi, S; Chun, YJ; Chung, MW; Han, S; Kim, D; Lee, CH; Na, HS; Shin, HJ; Yun, CH1
Rahnasto-Rilla, M; Raunio, H1
Murphy, SE; Retzlaff, C; von Weymarn, LB1
Cappendijk, SL; Miksys, S; Perry, WM; Tyndale, RF; Zhao, B1
van Dam, NM1
Chiba, M; Ishii, Y; Yamada, H; Yamamiya, I; Yoshisue, K1
Chun, YJ; Han, S; Kim, D; Kim, JH; Lee, H; Lim, YR; Park, HG; Park, SW1
Endo, D; Inoue, H; Kirisawa, R; Kitazawa, T; Komatsu, T; Kubota, A; Okamatsu, G; Onaga, T; Teraoka, H; Uchide, T; Uno, Y; Yin, G1
Capelo, JL; Cavaleiro, JA; Faustino, MA; Lodeiro, C; Menezes, JC; Neves, Mda G; Oliveira, E; Santos, CI; Santos, HM1
Biala, G; Budzynska, B; Kruk-Slomka, M; Skalicka-Wozniak, K; Wydrzynska-Kuzma, M1
Hirasawa, N; Hiratsuka, M; Hosono, H; Kumondai, M; Maekawa, M; Mano, N; Oda, A; Yamaguchi, H2
Chaurasia, DK; Katara, P; Kesharwani, A; Yadav, A1

Reviews

4 review(s) available for nicotine and warfarin

ArticleYear
[On certain embryopathies induced by teratogenic agents (author's transl].
    Monatsschrift fur Kinderheilkunde, 1977, Volume: 125, Issue:6

    Topics: Abnormalities, Drug-Induced; Aminopterin; Busulfan; Chlorambucil; Cyclophosphamide; Ethanol; Germany, West; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Lysergic Acid Diethylamide; Mercaptopurine; Nicotine; Phenytoin; Radiation Injuries; Teratogens; Thalidomide; Trimethadione; Warfarin

1977
Drug excretion in breast milk.
    Postgraduate medicine, 1974, Volume: 56, Issue:4

    Topics: Anti-Bacterial Agents; Barbiturates; Biological Transport, Active; Breast; Breast Feeding; Caffeine; Chloramphenicol; Contraceptives, Oral; Coumarins; Female; Fluorine; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Lactation; Meprobamate; Milk, Human; Models, Biological; Morphine; Nicotine; Pesticides; Pharmaceutical Preparations; Phenytoin; Potassium Iodide; Pregnancy; Salicylates; Sulfonamides; Time Factors

1974
Pharmacologic target-mediated drug disposition.
    Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:3

    Topics: Animals; Biotransformation; Models, Biological; Nicotine; Pharmacokinetics; Tissue Distribution; Warfarin

1994
CYP2A6: genetics, structure, regulation, and function.
    Drug metabolism and drug interactions, 2012, May-05, Volume: 27, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Mice; Models, Molecular; Multigene Family; Neoplasms; Nicotine; Nicotinic Agonists; Polymorphism, Genetic; Smoking; Substrate Specificity

2012

Trials

2 trial(s) available for nicotine and warfarin

ArticleYear
In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.
    Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Anticoagulants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Drug Combinations; Female; Gene Frequency; Genotype; Humans; Hydroxyethylrutoside; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Nicotinic Agonists; Phenotype; Polymethacrylic Acids; Polymorphism, Genetic; Polyvinyls; Thailand; Tobacco Use Cessation Devices; Umbelliferones

2006
Artemisinin and CYP2A6 activity in healthy subjects.
    European journal of clinical pharmacology, 2008, Volume: 64, Issue:3

    Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP2A6; Enzyme Induction; Humans; Male; Mixed Function Oxygenases; Nicotine; Tandem Mass Spectrometry; Umbelliferones; Vietnam

2008

Other Studies

41 other study(ies) available for nicotine and warfarin

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
    Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4

    Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
The influence of methyl groups on toxicity and drug metabolism.
    International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 7, Issue:1

    Topics: Administration, Oral; Amphetamine; Animals; Carbon Isotopes; Coumarins; Enzyme Induction; Female; Humans; Mephobarbital; Methylation; Microscopy, Electron; Microsomes, Liver; Nicotine; Phenobarbital; Phenols; Phospholipids; Pyrazoles; Rats; Structure-Activity Relationship; Tritium

1973
Effect of photoperiod and end-of-day light quality on alkaloids and phenolic compounds of tobacco.
    Plant physiology, 1970, Volume: 45, Issue:3

    Topics: Alkaloids; Chlorogenic Acid; Coumarins; Cyclohexanecarboxylic Acids; Light; Nicotiana; Nicotine; Periodicity; Plants, Toxic; Quinic Acid; Rutin; Tropanes

1970
[Fractionation of cigarette smoke condensate. II. Gel filtration chromatography of the fluorescing components of a water-soluble fraction of cigarette smoke condensate].
    Journal of chromatography, 1969, Mar-25, Volume: 40, Issue:2

    Topics: Alkaloids; Chemistry Techniques, Analytical; Chromatography, Gel; Coumarins; Cyclic N-Oxides; Fluorescence; Indoles; Nicotiana; Nicotine; Nicotinic Acids; Plants, Toxic; Smoking; Water

1969
CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians.
    Archives of toxicology, 2000, Volume: 73, Issue:10-11

    Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; DNA; DNA Primers; Gene Deletion; Genotype; Humans; Japan; Microsomes, Liver; Mixed Function Oxygenases; Mutation; Nicotine; Oxidation-Reduction; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; White People

2000
Effect of cigarette smoking on coumarin metabolism in humans.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2000, Volume: 2, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Ganglionic Stimulants; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Smoking

2000
Determination of coumarin metabolism in Turkish population.
    Human & experimental toxicology, 2001, Volume: 20, Issue:4

    Topics: Adult; Aged; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Gene Frequency; Genotype; Humans; Isoenzymes; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Phenotype; Point Mutation; Polymorphism, Genetic; Smoking; Turkey; Umbelliferones

2001
Diversity of selective environmental substrates for human cytochrome P450 2A6: alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine.
    Toxicology letters, 2003, Sep-15, Volume: 144, Issue:1

    Topics: Adult; Antibodies, Blocking; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Coumarins; Cytochrome P-450 CYP2A6; Diethylnitrosamine; Dimethylnitrosamine; Environmental Pollutants; Enzyme Inhibitors; Ethers; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Nicotine; Substrate Specificity

2003
Inhibition of human liver microsomal (S)-nicotine oxidation by (-)-menthol and analogues.
    Chemical research in toxicology, 2003, Volume: 16, Issue:8

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Haplorhini; Humans; In Vitro Techniques; Menthol; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Smoking; Stereoisomerism; Steroid Hydroxylases

2003
Scopolin: its isolation, characterization and relation to nicotine metabolism in harvested tobacco.
    Archives of biochemistry and biophysics, 1963, Volume: 100

    Topics: Biochemical Phenomena; Coumarins; Glucosides; Humans; Nicotiana; Nicotine

1963
Inhibitory effects of neurotransmitters and steroids on human CYP2A6.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:4

    Topics: Aldehyde Oxidase; Androgens; Animals; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cell Line; Corticosterone; Coumarins; Cytochrome P-450 CYP2A6; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Estrogens; Histamine; Hormones; Humans; Hydroxylation; In Vitro Techniques; Insecta; Liver; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Neurotransmitter Agents; Nicotine; Norepinephrine; Phenotype; Recombinant Proteins; Serotonin; Tryptamines

2007
Dr. Stewart A. Brown (PSNA phytochemistry pioneer).
    Phytochemistry, 2007, Volume: 68, Issue:14

    Topics: Awards and Prizes; Biochemistry; Canada; Coumarins; History, 20th Century; Lignin; Methylation; Nicotine; Plants; Societies, Scientific

2007
Flexibility of human cytochromes P450: molecular dynamics reveals differences between CYPs 3A4, 2C9, and 2A6, which correlate with their substrate preferences.
    The journal of physical chemistry. B, 2008, Jul-10, Volume: 112, Issue:27

    Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Liver; Models, Molecular; Nicotiana; Nicotine; Pharmaceutical Preparations; Protein Conformation; Steroids; Substrate Specificity; Temperature

2008
Conceptual DFT properties-based 3D QSAR: analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme.
    Journal of computational chemistry, 2009, Volume: 30, Issue:12

    Topics: Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Humans; Imidazoles; Models, Chemical; Models, Molecular; Nicotine; Protein Binding; Quantitative Structure-Activity Relationship; Quantum Theory

2009
Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35).
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:3

    Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Humans; Hydroxylation; Imidazoles; NADP; Nicotine; Oxidation-Reduction; Polymorphism, Single Nucleotide; Recombinant Proteins

2012
CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5'(1')iminium ion.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Chromatography, High Pressure Liquid; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Humans; Kinetics; NADP; Nicotiana; Nicotine; Nicotinic Agonists; Oxidation-Reduction; Tritium

2012
Nicotine kinetics in zebra finches in vivo and in vitro.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:6

    Topics: Animals; Brain; Coumarins; Finches; Humans; Male; Microsomes, Liver; Nicotine

2013
Plant chemical ecology finally gets to its root(s).
    Journal of chemical ecology, 2014, Volume: 40, Issue:3

    Topics: Alkaloids; Coumarins; Cyclopentanes; Ecology; Nicotine; Oxylipins; Pheromones; Plant Roots; Plants; Signal Transduction

2014
Effect of CYP2A6 genetic polymorphism on the metabolic conversion of tegafur to 5-fluorouracil and its enantioselectivity.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:9

    Topics: Cell Line; Coumarins; Cytochrome P-450 CYP2A6; DNA, Complementary; Escherichia coli; Fluorouracil; Humans; Microsomes, Liver; Nicotine; Polymorphism, Genetic; Sf9 Cells; Tegafur

2014
Directed-evolution analysis of human cytochrome P450 2A6 for enhanced enzymatic catalysis.
    Journal of toxicology and environmental health. Part A, 2014, Volume: 77, Issue:22-24

    Topics: Catalysis; Catalytic Domain; Coumarins; Cytochrome P-450 CYP2A6; Directed Molecular Evolution; Humans; Hydroxylation; Imidazoles; Liver; Mutagenesis; Mutation; Nicotine; Nitrosamines; Oxidation-Reduction; Protein Conformation; Protein Engineering; Recombinant Proteins

2014
Identification and functional characterization of novel feline cytochrome P450 2A.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:6

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cats; Cattle; Coumarins; Dogs; Gene Expression Regulation, Enzymologic; Humans; Liver; Nicotine; Organ Specificity; Swine

2015
Untangling interactions of a zinc(II) complex containing a coumarin-porphyrin unit with alkaloids in water solutions: a photophysical study.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2015, Volume: 14, Issue:4

    Topics: Caffeine; Cotinine; Coumarins; Ethanol; Fresh Water; Molecular Structure; Nicotine; Photochemical Processes; Porphyrins; Portugal; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis; Ultraviolet Rays; Zinc

2015
In vivo modulation of the behavioral effects of nicotine by the coumarins xanthotoxin, bergapten, and umbelliferone.
    Psychopharmacology, 2016, Volume: 233, Issue:12

    Topics: 5-Methoxypsoralen; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Coumarins; Cytochrome P-450 CYP2A6; Depression; Locomotion; Male; Memory; Methoxsalen; Mice; Nicotine; Nicotinic Agonists; Nootropic Agents; Swimming; Umbelliferones

2016
Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:3

    Topics: Alleles; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; HEK293 Cells; Humans; Hydroxylation; Kinetics; Microsomes; Models, Molecular; Nicotine; Oxidation-Reduction; Polymorphism, Genetic; Substrate Specificity; Transfection; Umbelliferones

2017
Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation.
    Drug metabolism and pharmacokinetics, 2018, Volume: 33, Issue:1

    Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Coumarins; Genetic Variation; HEK293 Cells; Humans; Hydroxylation; Imidazoles; Nicotine; Oxidation-Reduction; Protein Structure, Secondary

2018
Mining of molecular insights of CYP2A6 and its variants complex with coumarin (CYP2A6*-coumarin) using molecular dynamics simulation.
    Journal of biomolecular structure & dynamics, 2023, Volume: 41, Issue:9

    Topics: Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Mixed Function Oxygenases; Molecular Dynamics Simulation; Nicotine

2023