nicotine has been researched along with verapamil in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (16.95) | 18.7374 |
| 1990's | 15 (25.42) | 18.2507 |
| 2000's | 21 (35.59) | 29.6817 |
| 2010's | 13 (22.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Keserü, GM | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Bard, B; Carrupt, PA; Martel, S | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Leavitt, L; Mukhopadhyay, AK | 1 |
| Hasl, G; Heim, F; Mitznegg, P; Pauly, H; Schubert, E; Sprügel, W | 1 |
| Demling, L; Domschke, S; Domschke, W; Heim, F; Mitznegg, P; Schubert, E; Schwemmle, K; Strunz, U | 1 |
| Meikle, AW; Patterson, TR; Stringham, JD | 1 |
| Chen, YM; Dixon, WR | 1 |
| Höllt, V; Kley, N; Loeffler, JP; Pittius, CW | 1 |
| Goldstein, DS; Keiser, HR; Stull, R; Zimlichman, R; Zimlichman, S | 1 |
| Harish, OE; Kao, LS; Raffaniello, R; Schneider, AS; Wakade, AR | 1 |
| Koley, BN; Koley, J; Saha, JK | 2 |
| Culver, PJ; Rattan, S | 1 |
| Corcoran, JJ; Kirshner, N | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Sullivan, JP | 1 |
| Chowdhury, P; Doi, R; Imamura, M; Inoue, K; Nishikawa, M; Rayford, PL; Takaori, K | 1 |
| Czirfuzs, A; Fleckenstein-Grün, G; Frey, M; Matyas, S; Thimm, F | 1 |
| Chin, CW; Wong, JO; Wu, WH; Zbuzek, VK | 1 |
| Zimmers, T | 1 |
| Cohen, B; Wu, W; Zbuzek, VK | 1 |
| Blank, U; Clauss, W; Rückes, C; Weber, WM | 1 |
| Camoirano, A; Cartiglia, C; De Flora, S; Ferguson, L | 1 |
| Hussein, AA; Nabil, ZI; Rakha, MKh; Zalat, SM | 1 |
| Gaertner, LS; Morris, CE; Murray, CL | 1 |
| Ridley, DL; Rogers, A; Wonnacott, S | 1 |
| Amano, T; Hai-Du, Y; Katsura, M; Mohri, Y; Ohkuma, S; Sasa, M; Shuto, K; Tsujimura, A | 1 |
| Damaj, MI | 1 |
| Devane, CL; Donovan, JL; Markowitz, JS; Wang, JS | 1 |
| Barry, NG; Fife, JA; Fink, BF; Milan, ME; Rinker, B | 1 |
| Biala, G; Budzynska, B; Polak, P | 1 |
| Burgoon, LD; Johnstone, AF; Lin, BJ; Mack, CM; Shafer, TJ; Turner, JD | 1 |
| Akanuma, S; Hosoya, K; Kubo, Y; Tega, Y; Yuzurihara, C | 1 |
| Akanuma, SI; Ehrhardt, C; Hosoya, KI; Kubo, Y; Tega, Y; Yuzurihara, C | 1 |
1 review(s) available for nicotine and verapamil
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
58 other study(ies) available for nicotine and verapamil
| Article | Year |
|---|---|
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Evidence for an angiotensin receptor in esophageal smooth muscle of the opossum.
Topics: Angiotensin Amide; Angiotensin II; Animals; Atropine; Dose-Response Relationship, Drug; Esophagogastric Junction; Female; Hexamethonium Compounds; Male; Nicotine; Phentolamine; Phenylephrine; Receptors, Angiotensin; Receptors, Cell Surface; Saralasin; Tetrodotoxin; Vagus Nerve; Verapamil | 1978 |
Immediate X-radiation induced contractions of the isolated guinea pig terminal ileum: the localization of the effect by drugs.
Topics: Acetylcholine; Animals; Atropine; Diphenhydramine; Female; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nicotine; Tetrodotoxin; Time Factors; Verapamil; X-Rays | 1977 |
[Mode of action of bisacodyl (dulcolax) on isolated muscles of human colon (author's transl)].
Topics: Acetylcholine; Bisacodyl; Colon; Cresols; Diphenhydramine; Drug Antagonism; Histamine; Humans; Muscle Contraction; Muscle Tonus; Nicotine; Tetrodotoxin; Verapamil | 1975 |
Nicotine and cotinine inhibit steroidogenesis in mouse Leydig cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcimycin; Calcium; Cells, Cultured; Cotinine; Cyclic AMP; Depression, Chemical; Leydig Cells; Male; Mice; Nicotine; Pyrrolidinones; Smoking; Testosterone; Verapamil | 1990 |
The effect of etorphine on nicotine- and muscarine-induced catecholamine secretion from perfused rat adrenal glands.
Topics: Acetylcholine; Adrenal Glands; Animals; Epinephrine; Etorphine; Male; Mecamylamine; Morphinans; Muscarine; Nicotine; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Nicotinic; Verapamil | 1990 |
Involvement of ion channels in the induction of proenkephalin A gene expression by nicotine and cAMP in bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Glands; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Colforsin; Cyclic AMP; Enkephalins; Gallopamil; Gene Expression Regulation; Ion Channels; Nicotine; Nifedipine; Protein Precursors; RNA, Messenger; Sodium; Tubocurarine; Verapamil | 1987 |
Angiotensin II increases cytosolic calcium and stimulates catecholamine release in cultured bovine adrenomedullary cells.
Topics: Adrenal Medulla; Aminoquinolines; Angiotensin II; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Cytosol; Dopamine; Epinephrine; Fluorescent Dyes; Ion Channels; Nicotine; Norepinephrine; Potassium Chloride; Spectrometry, Fluorescence; Verapamil | 1987 |
Calcium dependence of muscarinic receptor-mediated catecholamine secretion from the perfused rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Atropine; Calcium; Catecholamines; Egtazic Acid; Electric Stimulation; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Muscarine; Nicotine; Perfusion; Rats; Receptors, Muscarinic; Verapamil | 1987 |
Effects of nicotine on spontaneous contractions of isolated atria of toad (Bufo melanostictus).
Topics: Animals; Atropine; Bufonidae; Caffeine; Edetic Acid; Hemicholinium 3; Hexamethonium Compounds; Hydroxydopamines; In Vitro Techniques; Myocardial Contraction; Nicotine; Oxidopamine; Physostigmine; Tyramine; Verapamil | 1987 |
Influence of loperamide on the internal anal sphincter in the opossum.
Topics: Anal Canal; Animals; Drug Interactions; Electric Stimulation; Female; Isoproterenol; Loperamide; Male; Naloxone; Nicotine; Opossums; Piperidines; Pressure; Rectum; Spinal Nerve Roots; Verapamil | 1987 |
Positive inotropic effect of nicotine on electrically evoked contraction of isolated toad ventricle.
Topics: Animals; Bufonidae; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Female; Guanethidine; Hemicholinium 3; Hexamethonium Compounds; In Vitro Techniques; Male; Myocardial Contraction; Nicotine; Propranolol; Tyramine; Ventricular Function; Verapamil | 1984 |
Inhibition of calcium uptake, sodium uptake, and catecholamine secretion by methoxyverapamil (D600) in primary cultures of adrenal medulla cells.
Topics: Adrenal Medulla; Animals; Biological Transport, Active; Calcium; Catecholamines; Cattle; Cells, Cultured; Gallopamil; Kinetics; Nicotine; Sodium; Tetrodotoxin; Verapamil; Veratridine | 1983 |
Functional modulation of human "ganglionic-like" neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cadmium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Isradipine; Neuroblastoma; Neurons; Nicotine; Nifedipine; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Receptors, Nicotinic; Spider Venoms; Tumor Cells, Cultured; Verapamil | 1995 |
Carbachol and cholecystokinin enhance accumulation of nicotine in rat pancreatic acinar cells.
Topics: Animals; Carbachol; Cholecystokinin; In Vitro Techniques; Male; Nicotine; Pancreas; Rats; Rats, Sprague-Dawley; Tritium; Verapamil | 1995 |
Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cells, Cultured; Cholecalciferol; Cholesterol; Coronary Vessels; Diltiazem; Disease Models, Animal; Humans; Hypertension; Middle Aged; Muscle, Smooth, Vascular; Nicotine; Nifedipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Risk Factors; Verapamil | 1994 |
The effect of nifedipine and verapamil on nicotine-induced antinociception in rats.
Topics: Analgesia; Animals; Drug Synergism; Male; Nicotine; Nifedipine; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Verapamil | 1994 |
Cases in electrocardiography.
Topics: Bradycardia; Drug Overdose; Electrocardiography; Female; Humans; Male; Middle Aged; Nicotine; Verapamil | 1994 |
Antinociceptive effect of nifedipine and verapamil tested on rats chronically exposed to nicotine and after its withdrawal.
Topics: Analgesics; Animals; Male; Nicotine; Nifedipine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Verapamil | 1997 |
Effects of nicotine on human nasal epithelium: evidence for nicotinic receptors in non-excitable cells.
Topics: Absorption; Aconitine; Amiloride; Calcium; Calcium Channel Blockers; Cells, Cultured; Extracellular Space; Humans; Intracellular Membranes; Nasal Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Osmolar Concentration; Receptors, Nicotinic; Sodium; Tetrodotoxin; Verapamil | 1997 |
Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism.
Topics: Acridines; Aminacrine; Benzo(a)pyrene; Calcium Channel Blockers; Chromates; Cyclophosphamide; Dopamine Antagonists; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Fluorenes; Indoles; Mutagenesis; Mutagenicity Tests; Mutagens; Mutation; Nicotine; Nitrogen Mustard Compounds; Quinolines; Salmonella typhimurium; Trifluoperazine; Verapamil | 1997 |
Mechanism of action of honey bee (Apis mellifera L.) venom on different types of muscles.
Topics: Animals; Atropine; Bee Venoms; Bufonidae; Calcium Channel Blockers; Electrocardiography; Heart; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth; Myocardial Contraction; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rabbits; Verapamil | 1998 |
Transepithelial transport of nicotine and vinblastine in isolated malpighian tubules of the tobacco hornworm (Manduca sexta) suggests a P-glycoprotein-like mechanism.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Atropine; Biological Transport; Epithelium; Malpighian Tubules; Manduca; Nicotine; Verapamil; Vinblastine | 1998 |
Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bacterial Toxins; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cells, Cultured; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; Hippocampus; Humans; Inhibitory Concentration 50; Marine Toxins; Microcystins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Tubocurarine; Tumor Cells, Cultured; Up-Regulation; Verapamil | 2001 |
Up-regulation of L-type voltage-dependent calcium channels after long term exposure to nicotine in cerebral cortical neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Blotting, Western; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Cerebral Cortex; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Ganglionic Stimulants; Immunoblotting; Kinetics; Mice; Neurons; Nicotine; Potassium Chloride; Protein Binding; RNA, Messenger; Time Factors; Up-Regulation; Verapamil | 2002 |
Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Nicotine; Nicotinic Agonists; Nimodipine; Pain Measurement; Reaction Time; Spinal Cord; Verapamil | 2005 |
P-glycoprotein does not actively transport nicotine and cotinine.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Cell Membrane; Cotinine; Humans; Nicotine; Verapamil | 2005 |
The effect of calcium channel blockers on smoking-induced skin flap necrosis.
Topics: Animals; Calcium Channel Blockers; Cotinine; Graft Survival; Male; Necrosis; Nicotine; Nifedipine; Rats; Rats, Wistar; Smoking; Surgical Flaps; Vasodilation; Verapamil | 2010 |
Effects of calcium channel antagonists on the motivational effects of nicotine and morphine in conditioned place aversion paradigm.
Topics: Animals; Avoidance Learning; Calcium Channel Blockers; Drug Administration Schedule; Flunarizine; Male; Morphine; Motivation; Nicotine; Nimodipine; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Verapamil | 2012 |
Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes.
Topics: Acetaminophen; Action Potentials; Animals; Cells, Cultured; Cerebral Cortex; Data Interpretation, Statistical; Fluoxetine; GABA Antagonists; Kainic Acid; Microelectrodes; Muscimol; Nerve Net; Neurons; Nicotine; Pesticides; Principal Component Analysis; Rats; Rats, Long-Evans; Verapamil | 2014 |
Carrier-Mediated Transport of Nicotine Across the Inner Blood-Retinal Barrier: Involvement of a Novel Organic Cation Transporter Driven by an Outward H(+) Gradient.
Topics: Animals; Biological Transport; Blood-Retinal Barrier; Carrier Proteins; Cations; Cell Line; Endothelial Cells; Hydrogen; Male; Nicotine; Organic Cation Transport Proteins; Pyrilamine; Rats; Rats, Wistar; Retina; Retinal Vessels; Verapamil | 2015 |
Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells.
Topics: Adrenergic beta-Agonists; Biological Transport; Cell Line, Tumor; Epithelial Cells; Humans; Nicotine; Organic Cation Transport Proteins; Pulmonary Alveoli; Pyrilamine; Verapamil | 2016 |