nicotine has been researched along with u-50488 in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Babovic-Vuksanovic, D; Heidbreder, CA; Shippenberg, TS; Shoaib, M | 1 |
| Hamann, SR; Martin, WR; Parvini, S | 1 |
| Choi, SR; Kim, YH; Lee, KJ; Song, DK; Suh, HW | 1 |
| Choi, SR; Chung, KM; Kim, YH; Song, DK; Suh, HW | 1 |
| Hahn, B; Shoaib, M; Stolerman, IP | 1 |
| Ise, Y; Nagase, H; Narita, M; Suzuki, T | 1 |
| Baba, S; Hiramatsu, M; Kojima, R; Nabeshima, T; Watanabe, M | 1 |
| Guaza, C; Llorente, R; Marco, EM; Moreno, E; Pérez-Alvarez, L; Viveros, MP | 1 |
| Cavun, S; Göktalay, G; Hamilton, JR; Levendusky, MC; Millington, WR | 1 |
| Ismayilova, N; Shoaib, M | 1 |
| Bruchas, MR; Chavkin, C; Gustin, RM; Martinelli, E; Schindler, AG; Smith, JS | 1 |
| Natividad, LA; O'Dell, LE; Orfila, JE; Tejeda, HA; Torres, OV | 1 |
| Coen, K; Funk, D; Grella, SL; Lê, AD; Li, Z | 1 |
| D'Souza, MS; Norman, H; Ward, M | 1 |
| Coen, K; Fletcher, PJ; Funk, D; Lê, AD; Tamadon, S | 1 |
| D'Souza, MS; Pham, H; Seeley, SL | 1 |
16 other study(ies) available for nicotine and u-50488
| Article | Year |
|---|---|
Development of behavioral sensitization to cocaine: influence of kappa opioid receptor agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Locomotion; Male; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensitivity and Specificity; Sodium Chloride | 1995 |
Pharmacologic characteristics of a medullary hyperalgesic center.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Ethylketocyclazocine; Female; Hyperalgesia; Medulla Oblongata; Morphine; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1993 |
Intrathecally injected nicotine enhances the antinociception induced by morphine but not beta-endorphin, D-Pen2,5-enkephalin and U50,488H administered intrathecally in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Pyrrolidines; Receptors, Opioid, delta; Spinal Cord | 1996 |
Nicotine enhances morphine- and beta-endorphin-induced antinociception at the supraspinal level in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nociceptors; Pain; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Kappa-opioid receptor modulation of nicotine-induced behaviour.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Motor Activity; Naltrexone; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats; Receptors, Opioid, kappa | 2000 |
Modulation of kappa-opioidergic systems on mecamylamine-precipitated nicotine-withdrawal aversion in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Aversive Therapy; Conditioning, Psychological; Male; Mecamylamine; Morphinans; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spiro Compounds; Substance Withdrawal Syndrome | 2002 |
Alpha 7-type nicotinic acetylcholine receptor and prodynorphin mRNA expression after administration of (-)-nicotine and U-50,488H in beta-amyloid peptide (25-35)-treated mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Enkephalins; Gene Expression Regulation; Male; Mice; Nicotine; Peptide Fragments; Protein Precursors; Receptors, Nicotinic; RNA, Messenger | 2004 |
The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Corticosterone; Drug Interactions; Endocrine System; Male; Maze Learning; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2005 |
Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Avoidance Learning; Conditioning, Psychological; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Time Factors | 2006 |
Alteration of intravenous nicotine self-administration by opioid receptor agonist and antagonists in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Feeding Behavior; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Self Administration; Tobacco Use Disorder | 2010 |
Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Conditioning, Operant; Dynorphins; Male; Mice; Mice, Inbred C57BL; Nicotine; Receptors, Opioid, kappa; Stress, Psychological; Swimming | 2012 |
Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Male; Naltrexone; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2012 |
Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Conditioning, Operant; Drug Administration Schedule; Drug Interactions; Extinction, Psychological; Male; Naltrexone; Nicotine; Nicotinic Agonists; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration; Stress, Psychological; Tobacco Use Disorder; Yohimbine | 2014 |
Effects of pharmacological manipulation of the kappa opioid receptors on the aversive effects of nicotine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Avoidance Learning; Conditioning, Operant; Male; Naltrexone; Narcotic Antagonists; Nicotine; Rats; Rats, Wistar; Receptors, Opioid, kappa; Taste | 2018 |
Kappa opioid receptors mediate yohimbine-induced increases in impulsivity in the 5-choice serial reaction time task.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Attention; Choice Behavior; Dose-Response Relationship, Drug; Ethanol; Impulsive Behavior; Male; Neurotransmitter Agents; Nicotine; Rats, Long-Evans; Receptors, Opioid, kappa; Yohimbine | 2019 |
Pharmacological activation of kappa opioid receptors in the nucleus accumbens core and ventral tegmental area increases the aversive effects of nicotine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Opioid, kappa; Tobacco Use Disorder; Ventral Tegmental Area | 2022 |