nicotine has been researched along with trans-metanicotine in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.76) | 18.7374 |
| 1990's | 5 (11.90) | 18.2507 |
| 2000's | 22 (52.38) | 29.6817 |
| 2010's | 11 (26.19) | 24.3611 |
| 2020's | 2 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Damaj, MI; Dogruer, D; Dukat, M; Glennon, RA; Lee, M; Martin, BR | 1 |
| Adolfs, TJ; Barkhuijsen, N; Coolen, HK; den Hartog, AP; Keizer, H; Kruse, CG; Mons, H; Reinders, JH; Stoit, AR; Stroomer, C; van der Neut, M; van Schaik, S | 1 |
| Benson, LR; Bhatti, BS; Breining, SR; Byrd, GD; Fedorov, NB; Hepler, CD; Hooker, DN; Kiser, MN; Lucero, LM; Lukas, RJ; Melvin, M; Mitchener, JP; Reynolds, LA; Sidach, SS; Whiteaker, P; Yohannes, D; Zhang, J | 1 |
| Bowman, ER; Chang, RS; McKennis, H; Wilson, KL | 1 |
| Dominiak, P; Fuchs, G; Grobecker, H; von Toth, S | 1 |
| Giacobini, E; Lippiello, P; Summers, KL | 1 |
| Arrington, S; Bencherif, M; Caldwell, WS; Fowler, KW; Lippiello, PM; Lovette, ME; Reeves, L | 1 |
| Bencherif, M; Collins, AC; Gray, JA; Grigoryan, G; Hodges, H; Lippiello, PM; Peters, S | 1 |
| Aceto, MD; Damaj, MI; Glassco, W; Martin, BR | 1 |
| Bencherif, M; Francis, MM; Lippiello, PM; Papke, RL; Webster, JC | 1 |
| Jang, J; Park, H; Sin, KS | 2 |
| Brown-Proctor, C; Kilbourn, MR; Sherman, PS; Snyder, SE | 1 |
| Papke, RL | 1 |
| Gu, JG; Nakatsuka, T; Papke, R; Takeda, D | 1 |
| Borta, A; Schwarting, RK | 1 |
| Gao, J; Hui, X; Ogiku, T; Suto, N; Wang, MW; Xie, X | 1 |
| Carrión, M; Delgado-García, JM; Rodríguez-Moreno, A | 1 |
| Bencherif, M; Gatto, GJ; Greinwald, R; Herfarth, H; Paetzel, C; Rogler, G; Schoelmerich, J; Spoettl, T | 1 |
| DeChon, J; Hu, G; Hu, J; Liu, Q; Wu, J; Yan, KC | 1 |
| Duty, S; O'Neill, MJ; Visanji, NP | 1 |
| Dar, MS; Smith, AD | 3 |
| Abdin, MJ; Dohi, T; Kitayama, S; Kitayama, T; Morioka, N; Morita, K; Nakashima, T | 1 |
| Fedotova, YO; Kuznetsova, NN; Sapronov, NS | 1 |
| Flood, P; Lu, J; Payappilly, J; Rowley, TJ | 1 |
| Al-Rejaie, S; Saeed Dar, M; Taslim, N | 1 |
| Hu, J; Jin, G; Liu, Q; Lucero, L; Lukas, RJ; Wu, J; Yang, K; Zhen, X; Zheng, C | 1 |
| Allison, C; Rushforth, SL; Shoaib, M; Wonnacott, S | 1 |
| Bucci, DJ; MacLeod, JE; Vucovich, MM | 1 |
| Dar, MS; Soderstrom, K; Taslim, N | 1 |
| Hijioka, M; Hisatsune, A; Ishibashi, H; Isohama, Y; Katsuki, H; Matsushita, H | 1 |
| Galarraga, E; Galindo-Charles, L; Garduño, J; Hernandez-Lopez, S; Jiménez-Rodríguez, J; Mihailescu, S; Tapia, D | 1 |
| Fedotova, IuO | 2 |
| Fedotova, IuO; Sapronov, NS | 1 |
| Fedotova, IuO; Frolova, HO | 1 |
| Grayson, B; Harte, MK; Marsh, S; McLean, SL; Neill, JC; Zarroug, SH | 1 |
| Winger, G | 2 |
1 review(s) available for nicotine and trans-metanicotine
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
41 other study(ies) available for nicotine and trans-metanicotine
| Article | Year |
|---|---|
3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.
Topics: Animals; Butanols; Cerebellum; Protein Binding; Pyridines; Rats; Receptors, Nicotinic | 2004 |
7-Azaindole derivatives as potential partial nicotinic agonists.
Topics: Alkaloids; Animals; Aza Compounds; Azocines; Brain; Indoles; Kinetics; Neurons; Nicotinic Agonists; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic | 2008 |
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Electrophysiology; Humans; Kidney; Ligands; Molecular Structure; Neuroblastoma; Nicotine; Protein Subunits; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2012 |
Nicotine-like actions of cis-metanicotine and trans-metanicotine.
Topics: Animals; Aorta, Thoracic; Atropine; Cocaine; Drug Interactions; Hexamethonium Compounds; In Vitro Techniques; Intestines; Male; Muscle Contraction; Nicotine; Phentolamine; Pyridines; Rabbits; Stereoisomerism | 1976 |
Effects of nicotine and its major metabolites on blood pressure in anaesthetized rats.
Topics: Animals; Blood Pressure; Cotinine; Dose-Response Relationship, Drug; Male; Nicotine; Rats; Rats, Inbred Strains | 1985 |
A microdialysis study of the effects of the nicotinic agonist RJR-2403 on cortical release of acetylcholine and biogenic amines.
Topics: Acetylcholine; Animals; Biogenic Amines; Cerebral Cortex; Dopamine; Dose-Response Relationship, Drug; Male; Microdialysis; Nicotine; Nicotinic Agonists; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin | 1996 |
RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.
Topics: Animals; Brain; Cell Line; Female; Humans; Mice; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley | 1996 |
RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization.
Topics: Animals; Avoidance Learning; Blood Pressure; Central Nervous System; Heart Rate; Male; Mice; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Rats, Wistar | 1996 |
Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist.
Topics: Analgesics; Animals; Binding, Competitive; Body Temperature; Discrimination Learning; Male; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic | 1999 |
The activation and inhibition of human nicotinic acetylcholine receptor by RJR-2403 indicate a selectivity for the alpha4beta2 receptor subtype.
Topics: Acetylcholine; Animals; Electric Conductivity; Female; Humans; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Xenopus laevis | 2000 |
A concise synthetic pathway for trans-metanicotine analogues.
Topics: Nicotine; Nicotinic Agonists | 2000 |
Synthesis and in vivo evaluation of (E)-N-[(11)C]Methyl-4- (3-pyridinyl)-3-butene-1-amine ([(11)C]metanicotine) as a nicotinic receptor radioligand.
Topics: Animals; Binding, Competitive; Brain Chemistry; Carbon Radioisotopes; Female; Macaca nemestrina; Mice; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Tomography, Emission-Computed | 2000 |
Synthesis of (+/-)-methyl-(1-aryl-4-pyridin-3-yl-but-3-enyl)-amines.
Topics: Nicotine; Nicotinic Agonists | 2001 |
Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403).
Topics: Acetylcholine; Amino Acid Sequence; Animals; Benzylidene Compounds; Electrophysiology; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pyridines; Rats; Receptors, Nicotinic; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 2002 |
Modulation of inhibitory synaptic activity by a non-alpha4beta2, non-alpha7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Alkaloids; Animals; Azocines; Choline; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Neural Inhibition; Nicotine; Nicotinic Agonists; Nootropic Agents; Patch-Clamp Techniques; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substantia Gelatinosa; Synaptic Transmission | 2003 |
Post-trial treatment with the nicotinic agonist metanicotine: Differential effects in Wistar rats with high versus low rearing activity.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Individuality; Male; Memory; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar | 2005 |
A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor.
Topics: Alkaloids; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Drug Evaluation, Preclinical; Embryo, Mammalian; Humans; Kidney; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Scintillation Counting | 2005 |
The nicotinic agonist RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801.
Topics: Animals; Blinking; Conditioning, Eyelid; Dizocilpine Maleate; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists | 2006 |
(E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cells, Cultured; Colon; Epithelial Cells; Granulocytes; Humans; Interleukin-8; Intestinal Mucosa; Leukocytes; Lipopolysaccharides; Monocytes; NF-kappa B; Nicotine; Sugar Acids; Tumor Necrosis Factor-alpha | 2007 |
Iptakalim inhibits nicotinic acetylcholine receptor-mediated currents in dopamine neurons acutely dissociated from rat substantia nigra pars compacta.
Topics: Acetylcholine; Action Potentials; Animals; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Propylamines; Rats; Rats, Wistar; Receptors, Nicotinic; Substantia Nigra | 2006 |
Nicotine, but neither the alpha4beta2 ligand RJR2403 nor an alpha7 nAChR subtype selective agonist, protects against a partial 6-hydroxydopamine lesion of the rat median forebrain bundle.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Brain Injuries; Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Ethers; Hydrocarbons, Fluorinated; Immunohistochemistry; Male; Medial Forebrain Bundle; Nicotine; Nicotinic Agonists; Oxidopamine; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2006 |
Mouse cerebellar nicotinic-cholinergic receptor modulation of Delta9-THC ataxia: role of the alpha4beta2 subtype.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cannabinoid Receptor Agonists; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Hexamethonium; Male; Marijuana Abuse; Mice; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Cannabinoid; Receptors, Nicotinic; Smoking; Time Factors | 2006 |
Analgesic action of nicotine on tibial nerve transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Choline; Hyperalgesia; Injections, Spinal; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Glycine; Receptors, Nicotinic; Spinal Cord; Tibial Nerve | 2006 |
Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxide.
Topics: Animals; Area Under Curve; Cerebellar Ataxia; Cerebellum; Chalcones; Cyclic GMP; Dronabinol; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Microinjections; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitroprusside; Oxadiazoles; Postural Balance; Quinoxalines; Receptor, Cannabinoid, CB1; Receptors, Nicotinic; Stereotaxic Techniques | 2007 |
Behavioral cross-tolerance between repeated intracerebellar nicotine and acute Delta(9)-tetrahydrocannabinol-induced cerebellar ataxia: role of cerebellar nitric oxide.
Topics: Animals; Cerebellar Ataxia; Cerebellum; Dihydro-beta-Erythroidine; Dronabinol; Drug Tolerance; Hexamethonium; Male; Mice; Nicotine; Nitric Oxide | 2007 |
Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia.
Topics: Acetylcholine; Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Drug Therapy, Combination; Estradiol; Female; Mecamylamine; Nicotine; Nicotinic Agonists; Ovariectomy; Rats; Rats, Wistar; Receptors, Nicotinic | 2006 |
The antinociceptive response to nicotinic agonists in a mouse model of postoperative pain.
Topics: Analgesics; Anesthetics, Inhalation; Animals; Behavior, Animal; Female; Isoflurane; Ligands; Mice; Nicotine; Nicotinic Agonists; Oxygen; Pain, Postoperative; Pressure; Spinal Cord; Synapses | 2008 |
Attenuation of ethanol-induced ataxia by alpha(4)beta(2) nicotinic acetylcholine receptor subtype in mouse cerebellum: a functional interaction.
Topics: Animals; Ataxia; Blotting, Western; Central Nervous System Depressants; Cerebellum; Dihydro-beta-Erythroidine; Ethanol; Male; Membranes; Mice; Microinjections; Nicotine; Nicotinic Agonists; Oligodeoxyribonucleotides; Postural Balance; Receptors, Nicotinic; Stereotaxic Techniques | 2008 |
Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons.
Topics: Acetylcholine; Aconitine; Action Potentials; Alkaloids; Animals; Azocines; Brain; Choline; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; Gene Expression; Kinetics; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Protein Subunits; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2009 |
Subtype-selective nicotinic agonists enhance olfactory working memory in normal rats: a novel use of the odour span task.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azabicyclo Compounds; Male; Mecamylamine; Memory, Short-Term; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Odorants; Olfactory Perception; Rats; Receptors, Nicotinic; Scopolamine; Thiophenes | 2010 |
Differential effects of nicotinic acetylcholine receptor stimulation on negative occasion setting.
Topics: Animals; Attention; Discrimination Learning; Inhibition, Psychological; Nicotine; Nicotinic Agonists; Rats; Rats, Long-Evans; Receptors, Nicotinic | 2010 |
Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Ethanol; Injections, Intraventricular; Male; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nitrates; Nitrites; Psychomotor Performance; Receptors, Nicotinic; Time Factors | 2011 |
α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Blotting, Western; Body Water; Brain; Brain Chemistry; Brain Edema; Cell Count; Cerebral Hemorrhage; Collagenases; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Microglia; Neurons; Nicotine; Nicotinic Agonists; Receptors, Nicotinic | 2012 |
Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Aconitine; Animals; Animals, Newborn; Atropine; Bicuculline; Cadmium Chloride; Chelating Agents; Cholinergic Agonists; Dihydro-beta-Erythroidine; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Indoles; Male; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Physostigmine; Presynaptic Terminals; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Nicotinic; Ryanodine; Serotonergic Neurons; Serotonin; Sodium Channel Blockers; Tetrodotoxin | 2012 |
[Influence of agonist and antagonist Nalpha7-cholinoreceptors on active avoidance learning and gonadal hormones levels in ovariectomized female rats].
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Cholinergic Agonists; Cholinergic Antagonists; Estradiol; Estrogens; Female; Gonadal Hormones; Mecamylamine; Nicotine; Ovariectomy; Rats; Receptors, Cholinergic; Receptors, Nicotinic | 2013 |
[Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats].
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Estradiol; Estrogens; Exploratory Behavior; Female; Grooming; Mecamylamine; Nicotine; Nicotinic Antagonists; Ovariectomy; Rats; Rats, Wistar; Receptors, Cholinergic | 2013 |
[Effect of alpha4beta2 nicotinic acetylcholine receptor agonists and antagonists on learning in female rats during different phases of ovary cycle].
Topics: Animals; Avoidance Learning; Estrous Cycle; Female; Learning; Maze Learning; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Subunits; Rats; Receptors, Nicotinic | 2014 |
[Influence of stimulation and blockade of α4β2 nicotinic acetylcholine receptors on learning of female rats in basic phases of ovary cycle].
Topics: Animals; Animals, Outbred Strains; Avoidance Learning; Drug Administration Schedule; Estrous Cycle; Female; Injections, Intraperitoneal; Maze Learning; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ovary; Rats; Receptors, Nicotinic; Space Perception; Water | 2014 |
Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzamides; Bridged Bicyclo Compounds; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Indans; Locomotion; Mental Recall; Nicotine; Nicotinic Agonists; Piperidines; Rats; Recognition, Psychology; Retention, Psychology; Risperidone | 2016 |
Nicotine-like discriminative and aversive effects of two α4β2-selective nicotine agonists, ispronicline and metanicotine.
Topics: Animals; Behavior, Animal; Cognition; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Monitoring; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Receptors, Nicotinic | 2021 |
Nicotinic aspects of the discriminative stimulus effects of arecoline.
Topics: Animals; Arecoline; Behavior, Animal; Dihydro-beta-Erythroidine; Discrimination Learning; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Receptors, Nicotinic; Substance-Related Disorders | 2021 |