nicotine has been researched along with s,n,n'-tripropylthiocarbamate in 500 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (1.40) | 18.7374 |
| 1990's | 25 (5.00) | 18.2507 |
| 2000's | 171 (34.20) | 29.6817 |
| 2010's | 234 (46.80) | 24.3611 |
| 2020's | 63 (12.60) | 2.80 |
| Authors | Studies |
|---|---|
| Di Chiara, G | 2 |
| Bennett, RH; Cherek, DR | 1 |
| Huston-Lyons, D; Kornetsky, C | 1 |
| Bauco, P; Carlezon, WA; Trojniar, W; Wise, RA | 1 |
| Acquas, E; Carboni, E; Di Chiara, G; Leone, P | 1 |
| Rosecrans, JA | 1 |
| Goldberg, SR; Katz, JL; Risner, ME | 1 |
| Russell, MA | 1 |
| Morrison, CF | 2 |
| Dawe, S; Gerada, C; Gray, JA; Russell, MA | 1 |
| Jayaraman, A; Kiba, H | 1 |
| Huston-Lyons, D; Kornetsky, C; Sarkar, M | 1 |
| Herberg, LJ; Montgomery, AM; Rose, IC | 1 |
| Dani, JA; Heinemann, S | 1 |
| Wise, RA | 1 |
| Baptista, M; Yeomans, J | 1 |
| Changeux, JP; Picciotto, MR; Zachariou, V; Zoli, M | 1 |
| Stolerman, I | 2 |
| Bauco, P; Marcangione, C; Wise, R | 1 |
| al-Adawi, S; Powell, J | 1 |
| Epping-Jordan, MP; Koob, GF; Markou, A; Watkins, SS | 1 |
| White, FJ | 1 |
| Rossing, MA | 1 |
| Cabeza de Vaca, S; Carr, KD | 1 |
| Bozarth, MA; KuoLee, R; Pudiak, CM | 2 |
| Behm, FM; Goldberg, JS; Johnson, MP; Rose, JE; Westman, EC | 1 |
| Crauthers, DM; Gilbert, DG; Jensen, RA; McClernon, FJ; Mooney, DK | 1 |
| Kelley, BM; Middaugh, LD | 1 |
| Koob, GF; Markou, A; Stinus, L; Watkins, SS | 1 |
| Itzhak, Y; Martin, JL | 1 |
| Kastellakis, A; Nomikos, G; Panagis, G; Spyraki, C | 1 |
| Corrigall, WA; Grottick, AJ; Higgins, GA; Huwyler, J; Malherbe, P; Trube, G; Wyler, R | 1 |
| Caggiula, AR; Donny, EC; Jacobs, KS; Mielke, MM; Rose, C; Sved, AF | 1 |
| Anstrom, K; Azarov, A; Chang, JY; Janak, P; Woodward, DJ | 1 |
| Böhme, GA; Cossu, G; Fattore, L; Fratta, W; Imperato, A; Ledent, C; Parmentier, M | 1 |
| Harrison, AA; Liem, YT; Markou, A | 1 |
| Dani, JA; Ji, D; Zhou, FM | 1 |
| Binzak, JM; Kelley, AE; Schroeder, BE | 1 |
| Miyata, H; Yanagita, T | 1 |
| Pogun, S | 1 |
| Markou, A; Paterson, NE | 2 |
| Hodge, CW; Koenig, HN; Nannini, MA; Olive, MF | 1 |
| Belluzzi, JD; Manzardo, AM; Stein, L | 1 |
| Gasparini, F; Harrison, AA; Markou, A | 1 |
| Dybing, E; Sanner, T | 1 |
| Keath, JR; Mansvelder, HD; McGehee, DS | 1 |
| Adriani, W; Laviola, G; Macrì, S; Pacifici, R | 1 |
| Lessiter, J; Powell, J; Tait, S | 1 |
| Alexson, TO; Laviolette, SR; van der Kooy, D | 1 |
| Castañé, A; Ledent, C; Maldonado, R; Parmentier, M; Valjent, E; Valverde, O | 1 |
| Berrendero, F; Kieffer, BL; Maldonado, R | 1 |
| McGeehan, AJ; Olive, MF | 1 |
| Kelley, AE; Schiltz, CA; Schroeder, BE | 1 |
| Behm, FM; Brauer, LH; Calkins, K; Cramblett, M; Lawhon, D; Rose, JE | 1 |
| Laviolette, SR; van der Kooy, D | 2 |
| Behm, FM; Coleman, RE; Hawk, TC; London, ED; Mathew, RJ; Rose, JE; Turkington, TG; Westman, EC | 1 |
| Bruijnzeel, AW; Cryan, JF; Markou, A; Skjei, KL | 1 |
| Jentsch, JD; Olausson, P; Taylor, JR | 1 |
| Besheer, J; Bevins, RA | 2 |
| Markou, A; Skjei, KL | 1 |
| Booth, S; Caggiula, AR; Chaudhri, N; Clements, LA; Donny, EC; Evans-Martin, FF; Gharib, MA; Sved, AF | 1 |
| Gasparini, F; Kenny, PJ; Markou, A | 1 |
| Collu, M; Fadda, P; Fratta, W; Fresu, A; Scherma, M | 1 |
| Bruijnzeel, AW; Markou, A | 2 |
| Barron, S; Littleton, JM; Rogers, DT | 1 |
| DEMARCO, AO; GELLER, I; SEIFTER, J | 1 |
| Besheer, J; Bevins, RA; Metschke, DM; Palmatier, MI | 1 |
| Dar, R; Frenk, H | 1 |
| Brussaard, AB; De Rover, M; Mansvelder, HD; McGehee, DS | 1 |
| Markou, A; Semenova, S | 2 |
| Fagen, ZM; Keath, JR; Mansvelder, HD; McGehee, DS | 1 |
| Boutrel, B; Gasparini, F; Harrison, AA; Kenny, PJ; Koob, GF; Markou, A; Paterson, NE; Semenova, S; Skoubis, PD | 1 |
| Caggiula, A; Ciccocioppo, M; Conklin, C; Jacobs, L; Perkins, KA; Sayette, M | 1 |
| Cragg, SJ; Rice, ME | 1 |
| Bevins, RA; Palmatier, MI; Peterson, JL; Wilkinson, JL | 1 |
| Belluzzia, JD; Leslie, FM; Lotfipour, S; Loughlin, SE; Perez, L; Wang, R | 1 |
| Biala, G; Weglinska, B | 1 |
| Falahi, M; Ghoshooni, H; Khalili, M; Sabetkasaei, M; Sahraei, H; Zarrindast, MR | 1 |
| Belluzzi, JD; Leslie, FM; Wang, R | 1 |
| Collins, AC; Deshpande, P; Labarca, C; Lester, HA; Marks, MJ; McKinney, SL; Nashmi, R; Schwarz, J; Tapper, AR; Whiteaker, P | 1 |
| Nakahara, D | 1 |
| Crespo Galán, I; Gómez de Heras, R; González Cuevas, G; López-Moreno, JA; Navarro, M; Rodríguez de Fonseca, F; Trigo-Díaz, JM | 1 |
| Bevins, RA; Metschke, DM; Palmatier, MI; Wilkinson, JL | 1 |
| Berrendero, F; Bilkei-Gorzo, A; Galeote, L; Maldonado, R; Mendizábal, V; Robledo, P; Zimmer, A | 1 |
| Berkowitz, R; Blendy, JA; Lerman, C; Patterson, F; Perkins, KA; Strasser, A; Walters, CL | 1 |
| Alderson, HL; Latimer, MP; Winn, P | 1 |
| Blendy, JA; Cleck, JN; Kuo, YC; Walters, CL | 1 |
| Bergstrom, HC; Dailey, VK; Eppolito, AK; McDonald, CG; Smith, LN; Smith, RF; Wheeler, TL | 1 |
| Ichitani, Y; Iwasaki, T; Kawamura, T; Nonaka, H | 1 |
| Secko, D | 1 |
| Culligan, K; Kosten, T; Mouratidis, M; Sofuoglu, M; Yoo, S | 1 |
| Kenny, PJ; Markou, A | 2 |
| Bechara, A; Naqvi, NH | 1 |
| Bruijnzeel, AW; Froestl, W; Kenny, PJ; Markou, A; Paterson, NE; Wright, CD | 1 |
| Caggiula, A; Ciccocioppo, M; Conklin, C; Doyle, T; Perkins, KA; Sayette, M | 1 |
| Crooks, PA; Deaciuc, AG; Dwoskin, LP; Sumithran, SP; Wilkins, LH; Xu, R; Zhu, J | 1 |
| Adriani, W; Deroche-Gamonet, V; Laviola, G; Le Moal, M; Piazza, PV | 1 |
| Haeri-Rohani, A; Rezayof, A; Zarrindast, MR; Zatali, H | 1 |
| Belluzzi, JD; Changeux, JP; Granon, S; Leslie, FM; Salomon, L; Tassin, JP; Villégier, AS | 1 |
| Brown, SE; Damaj, MI; Grabus, SD; Martin, BR | 1 |
| Goldberg, SR; Le Foll, B; Wiggins, M | 1 |
| Funk, D; Lê, AD; Li, Z; Shram, MJ | 2 |
| Aw, A; Barrett, SP; Dagher, A; Kelly, JT; McBride, D | 1 |
| Bruijnzeel, AW; Goldberger, BA; Koob, GF; Markou, A; Merves, ML; O'Dell, LE; Parsons, LH; Richardson, HN; Smith, RT | 1 |
| Ballard, T; Feldon, J; Higgins, GA; Pryce, CR; Spinelli, S | 1 |
| Bienkowski, P; Korkosz, A; Kostowski, W; Plaznik, A; Taracha, E; Zatorski, P | 1 |
| Castañé, A; Ledent, C; Maldonado, R; Soria, G; Valverde, O | 1 |
| Agatsuma, S; Chen, K; Hiroi, N; Lee, M; Seif, I; Shih, JC; Zhu, H | 1 |
| Ashby, CR; Gardner, EL; Gilbert, J; Heidbreder, CA; Pak, AC; Pilla, M; Xi, ZX | 1 |
| Bruijnzeel, AW; Gold, MS; Wilson, C; Zislis, G | 1 |
| Bleich, S; Kornhuber, J; Lunkenheimer, B; Lunkenheimer, J; Schlabeck, M; Sperling, W; Thuerauf, N; Wiltfang, J | 1 |
| Dawkins, L; Pickering, A; Powell, J; Powell, JH; West, R | 2 |
| Bassareo, V; De Luca, MA; Di Chiara, G | 1 |
| Caggiula, AR; Donny, EC; Liu, X; Palmatier, MI; Sved, AF | 1 |
| Liechti, ME; Markou, A | 2 |
| Fukakusa, A; Ito, M; Kamei, H; Mizoguchi, H; Nabeshima, T; Nagai, T; Nakamichi, N; Takuma, K; Yamada, K | 1 |
| Cryan, JF; Kaupmann, K; Lhuillier, L; Mombereau, C | 1 |
| Koob, GF; O'Dell, LE | 1 |
| Corrigall, WA; Heidbreder, CA; LeSage, MG; Ross, JT | 1 |
| McMillen, BA; Qin, W; Soderstrom, K; Taylor, DA; Williams, H | 1 |
| Belluzzi, JD; Leslie, FM; Lotfipour, S; McQuown, SC; Villégier, AS | 1 |
| Damaj, MI; Kota, D; Martin, BR; Robinson, SE | 1 |
| Bevins, RA; Li, C; Murray, JE; Palmatier, MI | 1 |
| Belluzzi, JD; Leslie, FM; Lotfipour, S; Villégier, AS | 1 |
| Bianchi, E; Cadet, P; Casares, FM; Esch, T; Fricchione, GL; Guarna, M; Kream, RM; Mantione, KJ; Stefano, GB; Zhu, W | 1 |
| Blendy, J; Jepson, C; Lerman, C; Patterson, F; Perkins, K; Ray, R; Rukstalis, M; Strasser, AA; Wileyto, P | 1 |
| De Vries, TJ; de Vries, W; Diergaarde, L; Hogenboom, F; Pattij, T; Poortvliet, I; Schoffelmeer, AN | 1 |
| Lajtha, A | 1 |
| Barr, RS; Culhane, MA; Evins, AE; Goff, DC; Pizzagalli, DA | 1 |
| Addy, NA; Brunzell, DH; Mineur, YS; Picciotto, MR | 1 |
| Fratta, W; González-Cuevas, G; López-Moreno, JA; Navarro, M; Rodríguez de Fonseca, F; Scherma, M | 1 |
| Mineur, YS; Picciotto, MR; Vieyra-Reyes, P | 1 |
| Damaj, MI; Kota, D; Martin, BR | 1 |
| Carlezon, WA; Chartoff, E; Kenny, PJ; Markou, A; Roberto, M | 1 |
| Mobascher, A; Winterer, G | 1 |
| Markou, A; Paterson, NE; Semenova, S | 1 |
| Froestl, W; Guery, S; Kaupmann, K; Markou, A; Paterson, NE; Vlachou, S | 1 |
| Damaj, MI; Lichtman, AH; Martin, BR; Merritt, LL; Walters, C | 1 |
| Brennan, CH; Cotter, FE; Cowe, YC; Hussain, O; Kily, LJ; McElwaine, S; Patel, S | 1 |
| Hollander, JA; Johnson, PM; Kenny, PJ | 1 |
| Boissoneault, J; Bruijnzeel, AW; Isaac, S; Prado, M; Rylkova, D; Shah, HP | 1 |
| Delgado, MR; Fiez, JA; Sayette, MA; Wilson, SJ | 1 |
| Natividad, LA; O'Dell, LE; Tejeda, HA; Torres, OV | 1 |
| Counotte, DS; De Vries, TJ; Hogenboom, F; Pattij, T; Schoffelmeer, AN; Smit, AB; Spijker, S; Van de Burgwal, LH | 1 |
| Balfour, DJ; Markou, A; Paterson, NE | 1 |
| Fallon, S; Lajtha, A; Sershen, H; Shearman, E | 1 |
| Coddington, SB; Jetton, C; Karelitz, JL; Lerman, C; Perkins, KA; Scott, JA; Wilson, AS | 2 |
| Ahtee, L; Chistyakov, V; Männistö, PT; Patkina, N; Skippari, J; Tammimäki, A; Zvartau, E | 1 |
| Goldberg, SR; Le Foll, B; Wertheim, CE | 1 |
| Bishop, SF; Lauzon, NM; Laviolette, SR; Sun, N; Tan, H | 2 |
| Coddington, S; Karelitz, JL; Lerman, C; Perkins, KA | 1 |
| Arends, MA; Fowler, CD; Kenny, PJ | 1 |
| Benowitz, NL; Bergen, AW; Ciccocioppo, MM; Conklin, CA; Grottenthaler, A; Lerman, C; Milanak, M; Perkins, KA | 1 |
| Baharnouri, G; Clarke, PB; McQuade, LE; Sellings, LH | 1 |
| Barnes, C; Fadda, P; Fattore, L; Fratta, W; Gamaleddin, I; Goldberg, SR; Haller, J; Justinová, Z; Le Foll, B; Medalie, J; Mikics, E; Panlilio, LV; Piomelli, D; Scherma, M; Stroik, J; Tanda, G; Yasar, S | 1 |
| Araki, H; Esumi, S; Gomita, Y; Kitamura, Y; Sagara, H; Sendo, T | 1 |
| Greenshaw, AJ; Hayes, DJ; Mosher, TM | 1 |
| Chiamulera, C; Fumagalli, G; Giuliano, C; Tedesco, V; Zangrandi, L | 1 |
| Bevins, RA; Palmatier, MI | 1 |
| Rose, JE | 3 |
| Bardo, MT; Crooks, PA; Dwoskin, LP; Joyce, BM; Neugebauer, NM; Pivavarchyk, M; Zhang, Z; Zheng, G | 1 |
| Caggiula, AR; Chaudhri, N; Donny, EC; Liu, X; Palmatier, MI; Sved, AF | 1 |
| Perkins, KA | 1 |
| Cameron, MD; Hollander, JA; Kamenecka, TM; Kenny, PJ; Lu, Q | 1 |
| Araki, H; Gomita, Y; Kitamura, Y; Sagara, H; Sendo, T; Shibata, K; Suemaru, K; Yae, T | 1 |
| Brunzell, DH; Grady, SR; King, SL; Lindstrom, JM; Marks, MJ; McIntosh, JM; Mineur, YS; Picciotto, MR | 1 |
| Alcantara, LF; Bolaños-Guzmán, CA; Iñiguez, SD; Maffeo, ML; Manojlovic, Z; Parise, EM; Schuh, B; Warren, BL | 1 |
| Nabeshima, T; Nagai, T; Yamada, K | 1 |
| Khroyan, TV; O'Dell, LE | 1 |
| Sofuoglu, M; Weinberger, AH | 1 |
| Pogun, S; Yararbas, G | 1 |
| Brunzell, DH; Mineur, YS; Neve, RL; Picciotto, MR | 1 |
| Bruijnzeel, AW; Isaac, S; Prado, M | 1 |
| Neisewander, JL; Sanabria, F; Thiel, KJ | 1 |
| Hagen, EH; Hammerstein, P; Kempter, R; Morris, G; Schmidt, R; Sullivan, RJ | 1 |
| Murphy, NP; Sakoori, K | 1 |
| Maldonado, R; Trigo, JM; Zimmer, A | 1 |
| Ashby, CR; Callahan, PM; Gardner, EL; Li, X; Spiller, K; Tehim, A; Xi, ZX | 1 |
| Harris, AC; Keyler, DE; LeSage, MG; Pentel, PR; Roiko, SA | 1 |
| Changeux, JP | 2 |
| Paterson, NE | 1 |
| Jin, GZ; Wu, J; Yang, KC | 1 |
| Kahler, CW; MacKillop, J | 1 |
| Imad Damaj, M; Kota, D; Robinson, SE | 1 |
| Natividad, LA; O'Dell, LE; Tejeda, HA; Torres, OV; Van Weelden, SA | 1 |
| Brunzell, DH; Damaj, MI; Jackson, KJ; McIntosh, JM; Sanjakdar, SS | 1 |
| Mao, D; McGehee, DS | 1 |
| Dani, JA; Dong, Y; Doyon, W; Doyon, WM; Li, W; Zhang, T | 1 |
| Bickel, WK; Burnett, CA; Kowal, BP; Landes, RD; Mueller, ET; Stitzer, ML; Yi, R | 1 |
| Caggiula, AR; Donny, EC; Levin, ME; Mays, KL; Palmatier, MI; Sved, AF | 1 |
| Lê, AD; Shram, MJ | 1 |
| Buccafusco, JJ; Hall, BJ; Pearson, LS | 1 |
| Dallery, J; Locey, ML | 2 |
| Dinter, C; Grosshans, M; Kiefer, F; Koopmann, A; Mann, K; Nakovics, H; Richter, A; Rockenbach, C; von der Goltz, C; Wiedemann, K; Winterer, G | 1 |
| Grieder, TE; Sellings, LH; Siu, EC; Ting-A-Kee, R; Tyndale, RF; van der Kooy, D; Vargas-Perez, H | 1 |
| Conklin, CA; Giedgowd, GE; Karelitz, JL; Perkins, KA; Sayette, MA | 1 |
| Berrendero, F; Maldonado, R; Martín-García, E; Robledo, P; Trigo, JM | 1 |
| Gracia, MC | 1 |
| Atzori, M; Brown, DC; Dinh, L; Nichols, JA; Thomas, F | 1 |
| Bauzo, RM; Bishnoi, M; Bruijnzeel, AW; Derendorf, H; Keijzers, KF; Kobeissy, FH; Sabarinath, SN; Shah, HP; Small, E; van Tuijl, IA; Yamada, H | 1 |
| Biala, G; Budzynska, B; Staniak, N | 1 |
| Carroll, FI; Damaj, MI; Jackson, KJ; Negus, SS | 1 |
| Beigzadeh, R; Meshkani, J; Rezayof, A; Rostami, P; Zarrindast, MR | 1 |
| Carta, S; Goldberg, SR; Lecca, S; Luchicchi, A; Muntoni, AL; Pillolla, G; Pistis, M; Yasar, S | 1 |
| Lajtha, A; Sershen, H | 1 |
| Brown, ML; Kellar, KJ; Levin, ED; Li, TK; Lumeng, L; McDowell, BE; Paige, MA; Petro, A; Rezvani, AH; Rose, JE; Slade, S; Wells, C; Xiao, Y | 1 |
| Der-Avakian, A; Markou, A | 1 |
| Blough, BE; Carroll, FI; Damaj, MI; Grabus, SD; King, LS; Lukas, RJ; Navarro, HA; Vann, RE; Warner, JA; Wiley, JL | 1 |
| Alexander, JC; Bishnoi, M; Bruijnzeel, AW; Ford, J; Keijzers, KF; Pasek, TM; van Tuijl, IA; Yamada, H; Yavarovich, KR | 1 |
| Barnes, C; Fadda, P; Fratta, W; Goldberg, SR; Justinova, Z; Le Foll, B; Lecca, S; Luchicchi, A; Mascia, P; Panlilio, LV; Piomelli, D; Pistis, M; Redhi, GH; Scherma, M; Tanda, G; Yasar, S | 1 |
| Harrison, EL; Lavery, M; McKee, SA; Sinha, R; Sofuoglu, M; Wanzer, J; Weinberger, AH | 1 |
| Aveyard, P; Lindson, N | 1 |
| O'Dell, LE | 1 |
| Hales, CA; Henehan, RM; Neugebauer, NM; Picciotto, MR | 1 |
| Blaha, CD; Chesler, EJ; Dickson, PE; Goldowitz, D; Lester, DB; Matta, SG; Miller, MM; Mittleman, G; Rogers, TD | 1 |
| Banerjee, D; Finn, MG; Froestl, W; Guery, S; Kaupmann, K; Markou, A; Paterson, NE; Vlachou, S | 1 |
| Fowler, CD; Johnson, PM; Kenny, PJ; Lu, Q; Marks, MJ | 1 |
| Cremers, TI; Folgering, JH; Kleijn, J; Rollema, H; van der Hart, MC; Westerink, BH | 1 |
| Belluzzi, JD; Dao, JM; Leslie, FM; Loughlin, SE; McQuown, SC | 1 |
| Dani, JA; De Biasi, M | 1 |
| Bespalov, AIu; Dravolina, OA; Zakharova, ES; Zvartau, EE | 1 |
| de Wit, H; Wignall, ND | 1 |
| Fadda, P; Fratta, W; Gamaleddin, I; Goldberg, SR; Justinová, Z; Le Foll, B; Makriyannis, A; Mascia, P; Panlilio, LV; Scherma, M; Vadivel, SK; Zanettini, C | 1 |
| Barrett, ST; Odum, AL | 1 |
| Cauley, M; Johnson, JE; Levin, ED; Petro, A; Rose, JE; Slade, S; Wells, C | 1 |
| Kapelewski, CH; Klein, LC; Vandenbergh, DJ | 1 |
| Green, R; Jenks, C; Lawyer, SR; Schoepflin, F | 1 |
| Alzoubi, K; Damaj, MI; Khabour, O; Kota, D; Marks, MJ; Sanjakdar, S | 1 |
| Fang, Q; He, YY; Li, FQ; Li, YQ; Liu, JF; Lu, L; Wang, JS; Xue, YX | 1 |
| Booker, TK; Grady, SR; Heinemann, SF; McGranahan, TM; Patzlaff, NE | 1 |
| Hall, MJ; O'Brien, LC; Palmatier, MI | 1 |
| Farquhar, MJ; Latimer, MP; Winn, P | 1 |
| Baudonnat, M; Besson, M; Cazala, P; Changeux, JP; Cloez-Tayarani, I; David, V; Gardier, AM; Granon, S; Guilloux, JP; Reperant, C | 1 |
| Lee, AM; Messing, RO | 1 |
| Huestis, M; Lee, M; Rose, EJ; Ross, TJ; Salmeron, BJ; Shakleya, DM; Stein, EA | 1 |
| Markou, A; Olivier, B; Stoker, AK | 1 |
| Alexander, JC; Bishnoi, M; Bruijnzeel, AW; Ford, J; Ji, Y; Rogers, JA; Scheick, S | 1 |
| Kahler, CW; Leventhal, AM; Monterosso, JR; Munafò, M; Sun, P; Sussman, S; Tidey, JW | 1 |
| Cao, GF; Chen, T; Dang, YH; Zhu, J | 1 |
| Harrod, SB; Hord, LL; Lacy, RT; Morgan, AJ | 1 |
| Adair, J; Aliczki, M; Barnes, C; Goldberg, SR; Haller, J; Heishman, SJ; Justinova, Z; Lecca, S; Luchicchi, A; Mascia, P; Panlilio, LV; Pistis, M; Redhi, GH; Yasar, S | 1 |
| Costa, G; Fenu, S; Morelli, M; Pinna, A; Plumitallo, A; Simola, N | 1 |
| Azar, MR; Carroll, FI; Damaj, MI; George, O; Harris, LS; Koob, GF; Tobey, KM; Vann, RE; Walentiny, DM; Wiley, JL | 1 |
| Berrendero, F; Bura, SA; Flores, Á; Galeote, L; Kieffer, BL; Maldonado, R; Plaza-Zabala, A | 1 |
| Damaj, MI; Lichtman, AH; Muldoon, PP; Parsons, LH | 1 |
| Bizon, JL; Gilbert, RJ; Mendez, IA; Setlow, B | 1 |
| Coen, K; Funk, D; Lê, AD; Li, S; Shram, MJ; Zou, S | 1 |
| Blendy, JA; Hilario, MR; Turner, JR | 1 |
| Bardo, MT; Berry, JN; Neugebauer, NM | 1 |
| Barrett, ST; Bevins, RA | 1 |
| Freeman, KS; Jones, SA; Marks, KR; Palmatier, MI; Sheppard, AB; Wissman, KM | 1 |
| Melis, M; Pistis, M | 1 |
| Andrés, ME; Bernabeu, RO; Pastor, V | 1 |
| Chavkin, C; Chavkin, NW; Gustin, RM; Hagan, CE; Lemos, JC; Messinger, DI; Neumaier, JF; Schattauer, SS; Schindler, AG; Shankar, H; Smith, JS | 1 |
| Chen, X; Damaj, MI; Jackson, KJ; Sanjakdar, SS | 1 |
| Feng, B; Guo, YY; Liu, SB; Ma, L; Song, Q; Wu, YM; Yang, Q; Zhao, DQ; Zhao, MG | 1 |
| Metin, S; Sengor, NS | 1 |
| Barnes, C; Goldberg, SR; Panlilio, LV; Solinas, M; Zanettini, C | 1 |
| Kelsey, JE; Niraula, A | 1 |
| Dixon-McDougall, T; Nowak, C; Pereira, S; Qian, C; Sellings, L; Tyndale, RF; van der Kooy, D; Zhao, B | 1 |
| Damaj, MI; Jackson, KJ; McIntosh, JM; Muldoon, PP; Sanjakdar, SS | 1 |
| Enoch, MA; Gallen, CL; Goldman, D; Hodgkinson, CA; Kurup, P; Lee, MR; Ross, TJ; Salmeron, BJ; Stein, EA | 1 |
| Karelitz, JL; Perkins, KA | 3 |
| Alajaji, M; Bowers, MS; Damaj, MI; Knackstedt, L | 1 |
| Brennan, KA; Putt, F; Truman, P | 1 |
| Coscas, S; Karila, L; Lowenstein, W; Petit, A; Reynaud, M; Zarmdini, R | 1 |
| Lewis, AS; Picciotto, MR | 1 |
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| Akinola, LS; Cravatt, BF; Damaj, MI; Lichtman, AH; Mahadevan, A; Muldoon, PP; Schlosburg, JE; Sim-Selley, LJ | 1 |
| Bermúdez, I; Cespedes, C; Esparza, E; Figueroa, C; González-Gutierrez, J; Hödar-Salazar, M; Iturriaga-Vásquez, P; Paillali, P; Quiroz, G; Reyes-Parada, M; Sotomayor-Zárate, R; Viscarra, F | 1 |
| Crissman, ME; Hempel, BJ; Madar, J; Melkumyan, M; Riley, AL; Winston, CA | 1 |
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| Leslie, FM | 1 |
| Akers, AT; Cooper, SY; Henderson, BJ | 1 |
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| Braida, D; Brennan, CH; Ponzoni, L; Sala, M; Teh, MT; Torres-Perez, JV | 1 |
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| Bernabeu, R; Pisera-Fuster, A; Zwiller, J | 1 |
| Clemens, KJ; Mastrogiovanni, NA; Wheeler, AK | 1 |
| Kenny, PJ; Wills, L | 1 |
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| Ahmed Yahia, T; Bousseyrol, E; Brito, R; Come, M; Dalkara, D; Didienne, S; Dongelmans, M; Durand-de Cuttoli, R; Duranté, EK; Faure, P; Hannesse, B; Lemoine, D; Marti, F; Mondoloni, S; Mourot, A; Naudé, J; Nguyen, C; Reynolds, LM; Torquet, N | 1 |
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59 review(s) available for nicotine and s,n,n'-tripropylthiocarbamate
| Article | Year |
|---|---|
Self-stimulation and drug reward mechanisms.
Topics: Animals; Brain; Cocaine; Humans; Nicotine; Phencyclidine; Reward; Self Stimulation; Substance-Related Disorders | 1992 |
Molecular and cellular aspects of nicotine abuse.
Topics: Animals; Dopamine; Humans; Nicotiana; Nicotine; Plants, Toxic; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Smoking; Substance-Related Disorders | 1996 |
Addictive drugs and brain stimulation reward.
Topics: Animals; Brain; Brain Mapping; Cannabinoids; Electric Stimulation; Humans; Narcotics; Nicotine; Phencyclidine; Reward; Self Stimulation; Substance-Related Disorders | 1996 |
Contribution of nicotinic acetylcholine receptors containing the beta 2-subunit to the behavioural effects of nicotine.
Topics: Analgesics; Animals; Behavior, Animal; Cognition; Humans; Macromolecular Substances; Mice; Mice, Mutant Strains; Nicotine; Receptors, Nicotinic; Reward; Smoking | 1997 |
Genetic influences on smoking: candidate genes.
Topics: Behavior, Addictive; Dopamine; Humans; Nicotine; Polymorphism, Genetic; Receptors, Dopamine; Reward; Smoking; Twin Studies as Topic | 1998 |
Role of dopamine in the behavioural actions of nicotine related to addiction.
Topics: Behavior, Addictive; Dopamine; Humans; Learning Disabilities; Locomotion; Motivation; Nicotine; Nicotinic Agonists; Reward; Tobacco Use Disorder | 2000 |
Activity patterns in mesolimbic regions in rats during operant tasks for reward.
Topics: Action Potentials; Animals; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Dopamine; Dopamine Agonists; Electrodes, Implanted; Ethanol; Haplorhini; Heroin; Limbic System; Models, Neurological; Nicotine; Nucleus Accumbens; Prefrontal Cortex; Psychomotor Performance; Rats; Reward; Species Specificity; Time Factors | 2000 |
Synaptic plasticity and nicotine addiction.
Topics: Animals; Cerebral Cortex; Dopamine; Humans; Limbic System; Neuronal Plasticity; Neurons; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Reward; Tobacco Use Disorder | 2001 |
Neurobiological mechanisms of nicotine craving.
Topics: Animals; Conditioning, Psychological; Environment; Humans; Nicotine; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2001 |
Sex differences in brain and behavior: emphasis on nicotine, nitric oxide and place learning.
Topics: Animals; Avoidance Learning; Behavior; Brain; Cognition; Female; Humans; Learning; Male; Nicotine; Nicotinic Agonists; Nitric Oxide; Rats; Reward; Sex Characteristics | 2001 |
[Nicotine dependence--medico-biological aspects].
Topics: Brain; Dopamine; Humans; Nicotine; Receptors, Dopamine; Receptors, Nicotinic; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2002 |
Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction.
Topics: Animals; Cholinergic Fibers; Dopamine; Humans; Interneurons; Nicotine; Receptors, Nicotinic; Reward; Substance-Related Disorders | 2003 |
Short- and long-term modulation of synaptic inputs to brain reward areas by nicotine.
Topics: Animals; Brain; Humans; Nicotine; Nicotinic Agonists; Receptors, Glutamate; Receptors, Nicotinic; Reward; Substance-Related Disorders; Synapses | 2003 |
Adolescent development of forebrain stimulant responsiveness: insights from animal studies.
Topics: Adolescent; Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Humans; Models, Animal; Nicotine; Nicotinic Agonists; Prosencephalon; Reward; Self Administration | 2004 |
Novelty reward as a measure of anhedonia.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Depression; Disease Models, Animal; Exploratory Behavior; Humans; Nicotine; Nicotinic Agonists; Reward; Substance Withdrawal Syndrome; Weights and Measures | 2005 |
Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis.
Topics: Alcohols; Animals; Cocaine; Humans; Models, Biological; Morphine; Nicotine; Reward; Signal Transduction | 2007 |
Interrelated mechanisms in reward and learning.
Topics: Animals; Brain; Learning; Neurotransmitter Agents; Nicotine; Reward | 2008 |
It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood.
Topics: Affect; Animals; Down-Regulation; Humans; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Reward; Signal Transduction; Tobacco Use Disorder; Up-Regulation | 2008 |
[Mechanisms of nicotine dependence].
Topics: Attention; Brain; Cognition; Humans; Models, Neurological; Models, Psychological; Nicotine; Reward; Stress, Psychological; Tobacco Use Disorder | 2008 |
Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Genetically Modified; Anxiety Disorders; Arousal; Comorbidity; Depressive Disorder; Genotype; Humans; Mice; Mice, Knockout; Nicotine; Phenotype; Receptors, Nicotinic; Reward; Schizophrenia; Signal Transduction; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Disrupting nicotine reinforcement: from cigarette to brain.
Topics: Animals; Brain; Cardiovascular System; Cats; Clinical Trials as Topic; Humans; Immunotherapy, Active; Neurotransmitter Agents; Nicotiana; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Reinforcement, Psychology; Respiratory System; Reward; Sensation; Smoke; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Multiple motivational forces contribute to nicotine dependence.
Topics: Animals; Arousal; Association Learning; Conditioning, Psychological; Ganglionic Stimulants; Humans; Motivation; Motor Activity; Nicotine; Rats; Reward; Smoking; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2009 |
New findings on nicotine addiction and treatment.
Topics: Animals; Benzazepines; Bupropion; Humans; Mecamylamine; Motivation; Nicotine; Nicotinic Antagonists; Quinoxalines; Reward; Smoking Cessation; Tobacco Use Disorder; Vaccines; Varenicline | 2009 |
Sex differences in nicotine reinforcement and reward: influences on the persistence of tobacco smoking.
Topics: Administration, Intranasal; Association Learning; Cues; Dose-Response Relationship, Drug; Female; Humans; Male; Motivation; Nicotine; Reinforcement, Psychology; Reward; Self Administration; Sex Factors; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Treatment Outcome | 2009 |
Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase-activated receptor 1.
Topics: Acetylcholine; Animals; Dopamine; Drug Delivery Systems; Fibrinolysin; Gene Expression; Humans; Mice; Mice, Knockout; Nicotine; Receptor, PAR-1; Reward; Tissue Plasminogen Activator; Tobacco Use Disorder | 2008 |
Rodent models of nicotine reward: what do they tell us about tobacco abuse in humans?
Topics: Animals; Disease Models, Animal; Humans; Mice; Nicotine; Nicotinic Agonists; Rats; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2009 |
The impact of cigarette smoking on stimulant addiction.
Topics: Brain; Central Nervous System Stimulants; Cognition Disorders; Comorbidity; Humans; Methamphetamine; Nicotine; Reward; Smoking; Socioeconomic Factors; Substance-Related Disorders; United States | 2009 |
Sex differences in nicotine action.
Topics: Animals; Cognition; Female; Humans; Male; Motor Activity; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Reward; Rodentia; Sex Factors; Smoking; Smoking Cessation; Tobacco Use Disorder | 2009 |
Ecology and neurobiology of toxin avoidance and the paradox of drug reward.
Topics: Animals; Avoidance Learning; Biological Evolution; Brain; Dopamine; Ecology; Humans; Models, Biological; Models, Neurological; Neurons; Neurotoxins; Nicotine; Nicotinic Agonists; Plants; Reward; Substance-Related Disorders | 2009 |
Nicotinic receptors and nicotine addiction.
Topics: Acetylcholine; Adolescent; Adult; Allosteric Regulation; Animals; Brain Chemistry; Genetic Predisposition to Disease; Humans; Ion Channels; Lung Neoplasms; Mice; Nicotine; Protein Subunits; Receptors, Nicotinic; Reward; Smoking; Synaptic Transmission; Tobacco Use Disorder; Torpedo; Ventral Tegmental Area | 2009 |
The neuropharmacological substrates of nicotine reward: reinforcing versus reinforcement-enhancing effects of nicotine.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Reinforcement, Psychology; Reward; Tobacco Use Disorder | 2009 |
Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology.
Topics: Animals; Dopamine; Drug Delivery Systems; Humans; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parkinson Disease; Protein Subunits; Receptors, Nicotinic; Reward; Tobacco Use Disorder; Ventral Tegmental Area | 2009 |
Nicotine and behavioral sensitization.
Topics: Animals; Behavior; Brain; Dopamine; Humans; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Reward; Synaptic Transmission; Tobacco Use Disorder; Ventral Tegmental Area | 2010 |
Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system.
Topics: Animals; Behavior, Addictive; Humans; Motivation; Naltrexone; Neurotransmitter Agents; Nicotine; Opioid Peptides; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Smoking Cessation; Tobacco Use Disorder | 2010 |
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice.
Topics: Animals; Behavior, Animal; Central Nervous System; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Transgenic; Models, Biological; Models, Molecular; Neural Pathways; Nicotine; Protein Subunits; Receptors, Nicotinic; Reward; Tobacco Use Disorder | 2010 |
Nicotine: alcohol reward interactions.
Topics: Age Factors; Alcoholism; Animals; Brain; Drug Interactions; Ethanol; Female; Humans; Male; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Receptors, Neurotransmitter; Receptors, Nicotinic; Reward; Sex Factors; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2010 |
An updated meta-analysis of nicotine preloading for smoking cessation: investigating mediators of the effect.
Topics: Databases, Factual; Humans; Models, Biological; Nicotine; Nicotinic Agonists; Odds Ratio; Outcome Assessment, Health Care; Reward; Smoking Cessation; Tobacco Use Disorder | 2011 |
Reward, addiction, withdrawal to nicotine.
Topics: Animals; Behavior, Addictive; Cerebral Cortex; Dopamine; Humans; Limbic System; Neuronal Plasticity; Neurons; Nicotine; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2011 |
[Behavioral mechanisms of nicotine dependence: a search for new drugs].
Topics: Drug Discovery; Excitatory Amino Acid Antagonists; Humans; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Reward; Smoking; Tobacco Use Disorder | 2010 |
Effect of the monoamine oxidase inhibition on rewarding effects of nicotine in rodents.
Topics: Animals; Brain; Drug Interactions; Monoamine Oxidase Inhibitors; Neurotransmitter Agents; Nicotine; Reward | 2011 |
[Structural plasticity associated with drugs addiction].
Topics: Amphetamine; Animals; Brain; Cocaine; Humans; Morphine; Neuronal Plasticity; Nicotine; Reward; Substance-Related Disorders; Synapses | 2011 |
The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence.
Topics: Amidohydrolases; Animals; Endocannabinoids; Enzyme Inhibitors; Humans; Mice; Nicotine; Nicotinic Agonists; Rats; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
Hub and switches: endocannabinoid signalling in midbrain dopamine neurons.
Topics: Animals; Arachidonic Acids; Dopamine; Dopaminergic Neurons; Endocannabinoids; Glycerides; Humans; Mesencephalon; Motivation; Nervous System Diseases; Nicotine; Receptor, Cannabinoid, CB1; Receptors, GABA; Reward; Substance-Related Disorders; Synaptic Transmission | 2012 |
[Tobacco use and illicit substance use disorders: what should we have to do?].
Topics: Behavior, Addictive; Cocaine-Related Disorders; Combined Modality Therapy; Comorbidity; Disease Susceptibility; Dopamine; Global Health; Humans; Illicit Drugs; Marijuana Abuse; Nicotine; Opioid-Related Disorders; Receptors, Dopamine D2; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Smoking; Smoking Cessation; Substance-Related Disorders; Tobacco Use Disorder | 2013 |
High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness.
Topics: Animals; Brain; Cognition; Humans; Mental Disorders; Nicotine; Protein Transport; Receptors, Nicotinic; Reward; Synaptic Transmission; Up-Regulation | 2013 |
[Reconsideration of nicotine and other substance dependence: a clue from dependence-related mentation including reward, motivation, learning, delusion and hallucination toward understanding the concept of non-substance-related addiction].
Topics: Animals; Delusions; Hallucinations; Humans; Learning; Motivation; Nicotine; Reward; Substance-Related Disorders; Tobacco Use Disorder | 2013 |
Smoking abstinence and neurocognition: implications for cessation and relapse.
Topics: Animals; Executive Function; Humans; Nicotine; Reward; Smoking; Substance Withdrawal Syndrome | 2015 |
Clock genes × stress × reward interactions in alcohol and substance use disorders.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Circadian Clocks; Circadian Rhythm Signaling Peptides and Proteins; Cocaine; Dopamine Uptake Inhibitors; Ethanol; Gene-Environment Interaction; Humans; Hypothalamo-Hypophyseal System; Nicotine; Nicotinic Agonists; Pituitary-Adrenal System; Reward; Stress, Psychological; Substance-Related Disorders | 2015 |
[Nicotine dependence].
Topics: Animals; Brain; Humans; Nicotine; Receptors, Nicotinic; Reward; Smoking Cessation; Tobacco Use Disorder | 2015 |
The neurobiological and behavioral overlaps of nicotine and food addiction.
Topics: Animals; Behavior, Addictive; Brain; Food; Humans; Neurobiology; Nicotine; Obesity; Rats; Reward | 2016 |
Endogenous opioid system: a promising target for future smoking cessation medications.
Topics: Analgesics, Opioid; Animals; Drug Delivery Systems; Forecasting; Humans; Nicotine; Opioid Peptides; Receptors, Opioid; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2017 |
The Gamma-Aminobutyric Acid B Receptor in Depression and Reward.
Topics: Allosteric Regulation; Anhedonia; Animals; Antidepressive Agents; Brain; Depression; Depressive Disorder, Major; GABA-B Receptor Agonists; Humans; Nicotine; Receptors, GABA-B; Reward; Stress, Psychological; Substance Withdrawal Syndrome | 2018 |
The modulatory role of nicotine on cognitive and non-cognitive functions.
Topics: Animals; Anxiety; Body Temperature; Body Weight; Brain; Cognition; Humans; Learning; Nicotine; Nicotinic Agonists; Pain; Receptors, Nicotinic; Reward; Substance-Related Disorders | 2019 |
Adolescent drug exposure: A review of evidence for the development of persistent changes in brain function.
Topics: Adolescent; Age Factors; Amphetamine; Animals; Brain; Cannabinoids; Cocaine; Cognition; Critical Period, Psychological; Dopamine; Ethanol; Humans; Illicit Drugs; Models, Animal; Nicotine; Prefrontal Cortex; Recreational Drug Use; Reward | 2020 |
Unique, long-term effects of nicotine on adolescent brain.
Topics: Adolescent; Age Factors; Animals; Behavior, Animal; Brain; Cognition; Electronic Nicotine Delivery Systems; Emotions; Female; Humans; Male; Nicotine; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome; United States; Vaping | 2020 |
Addiction-related neuroadaptations following chronic nicotine exposure.
Topics: Adaptation, Physiological; Animals; Dopamine; Humans; Nicotine; Receptors, Nicotinic; Reward; Tobacco Use Disorder | 2021 |
Neurobiological Mechanisms of Nicotine Reward and Aversion.
Topics: Brain; Humans; Nicotine; Receptors, Nicotinic; Reward; Tobacco Use Disorder | 2022 |
Anhedonia in Nicotine Dependence.
Topics: Anhedonia; Humans; Nicotine; Reward; Smoking; Tobacco Use Disorder | 2022 |
Reward and inhibition in obesity and cigarette smoking: Neurobiological overlaps and clinical implications.
Topics: Brain; Cigarette Smoking; Humans; Nicotine; Obesity; Reward | 2023 |
25 trial(s) available for nicotine and s,n,n'-tripropylthiocarbamate
| Article | Year |
|---|---|
Nicotine intake in smokers increases following a single dose of haloperidol.
Topics: Adult; Haloperidol; Humans; Male; Nicotine; Reward; Self Administration; Smoking; Substance Withdrawal Syndrome | 1995 |
Blockade of smoking satisfaction using the peripheral nicotinic antagonist trimethaphan.
Topics: Adolescent; Adult; Blood Pressure; Female; Heart Rate; Humans; Injections, Intravenous; Male; Middle Aged; Nicotine; Nicotinic Antagonists; Personal Satisfaction; Reward; Smoking; Trimethaphan | 1999 |
Effects of monetary contingencies on smoking relapse: influences of trait depression, personality, and habitual nicotine intake.
Topics: Depression; Humans; Male; Nicotine; Personality; Recurrence; Reward; Smoking; Smoking Cessation; Smoking Prevention | 1999 |
The influence of instructions and nicotine dose on the subjective and reinforcing effects of smoking.
Topics: Adult; Female; Humans; Male; Nicotine; Reinforcement, Psychology; Reward; Smoking | 2004 |
Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers.
Topics: Adult; Anticonvulsants; Arousal; Attention; Blood Pressure; Brain; Cross-Over Studies; Double-Blind Method; Female; gamma-Aminobutyric Acid; Heart Rate; Humans; Male; Neuropsychological Tests; Nicotine; Nipecotic Acids; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tiagabine | 2005 |
Sex differences in the influence of nicotine dose instructions on the reinforcing and self-reported rewarding effects of smoking.
Topics: Adult; Affect; Dose-Response Relationship, Drug; Female; Humans; Male; Motivation; Nicotine; Reward; Set, Psychology; Sex Factors; Smoking; Tobacco Use Disorder | 2006 |
Memantine fails to facilitate partial cigarette deprivation in smokers--no role of Memantine in the treatment of nicotine dependency?
Topics: Adult; Dopamine Agents; Double-Blind Method; Female; Humans; Male; Memantine; Nicotine; Nicotinic Agonists; Pilot Projects; Placebos; Reward; Smell; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Treatment Failure | 2007 |
A double-blind placebo controlled experimental study of nicotine: I--effects on incentive motivation.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Motivation; Nicotine; Nicotinic Agonists; Reward; Smoking; Smoking Cessation; Substance Withdrawal Syndrome | 2006 |
A single dose of nicotine enhances reward responsiveness in nonsmokers: implications for development of dependence.
Topics: Administration, Cutaneous; Adolescent; Adult; Analysis of Variance; Bias; Double-Blind Method; Humans; Middle Aged; Nicotine; Nicotinic Agonists; Reaction Time; Retrospective Studies; Reward; Smoking; Substance Withdrawal Syndrome | 2008 |
Effect of smoking opportunity on responses to monetary gain and loss in the caudate nucleus.
Topics: Adult; Arousal; Caudate Nucleus; Cues; Dominance, Cerebral; Feedback, Psychological; Humans; Magnetic Resonance Imaging; Male; Motivation; Nicotine; Oxygen; Reward; Smoking; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood.
Topics: Adult; Affect; Alleles; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Female; Genotype; Humans; Male; Minisatellite Repeats; Nicotine; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Receptors, Dopamine D3; Receptors, Dopamine D4; Receptors, Opioid, mu; Reinforcement, Psychology; Reward; Serotonin Plasma Membrane Transport Proteins; Set, Psychology; Smoking; Taq Polymerase; Tobacco Use Disorder; Young Adult | 2008 |
Delayed reward discounting predicts treatment response for heavy drinkers receiving smoking cessation treatment.
Topics: Adult; Alcohol Drinking; Counseling; Female; Humans; Male; Models, Psychological; Nicotine; Reward; Risk-Taking; Smoking; Smoking Cessation; Tobacco Use Disorder; Treatment Outcome | 2009 |
Acute negative affect relief from smoking depends on the affect situation and measure but not on nicotine.
Topics: Adult; Affect; Anxiety; Executive Function; Female; Humans; Male; Nicotine; Nicotinic Agonists; Reinforcement, Psychology; Reward; Smoking; Smoking Cessation; Social Environment; Stress, Psychological; Substance Withdrawal Syndrome | 2010 |
Stress decreases the ability to resist smoking and potentiates smoking intensity and reward.
Topics: Adrenocorticotropic Hormone; Adult; Behavior, Addictive; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Imagery, Psychotherapy; Male; Middle Aged; Motivation; Nicotine; Pituitary-Adrenal System; Reinforcement, Psychology; Reward; Smoking; Smoking Cessation; Stress, Psychological; Young Adult | 2011 |
Effects of nicotine on attention and inhibitory control in healthy nonsmokers.
Topics: Administration, Cutaneous; Adult; Attention; Blood Pressure; Cognition; Double-Blind Method; Female; Heart Rate; Humans; Inhibition, Psychological; Male; Nicotine; Nicotinic Agonists; Reward; Risk-Taking; Stroop Test; Transdermal Patch; Young Adult | 2011 |
Chronic exposure to nicotine is associated with reduced reward-related activity in the striatum but not the midbrain.
Topics: Adult; Case-Control Studies; Conditioning, Classical; Corpus Striatum; Cues; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Mesencephalon; Nicotine; Reward; Time Factors; Tobacco Use Cessation Devices; Tobacco Use Disorder | 2012 |
Repeated nicotine exposure during adolescence alters reward-related learning in male and female rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Conditioning, Classical; Conditioning, Operant; Female; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward; Sex Characteristics; Time Factors | 2014 |
Association between nicotine withdrawal and reward responsiveness in humans and rats.
Topics: Adult; Animals; Conditioning, Operant; Depression; Humans; Male; Nicotine; Rats; Reward; Smoking; Substance Withdrawal Syndrome; Young Adult | 2014 |
Dopaminergic genetic variation moderates the effect of nicotine on cigarette reward.
Topics: Adolescent; Adult; Aged; Dopamine; Double-Blind Method; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Minisatellite Repeats; Nicotine; Polymorphism, Single Nucleotide; Receptors, Dopamine D4; Reward; Smoking; Smoking Cessation; Tobacco Products; Young Adult | 2016 |
Neural Signatures of Cognitive Flexibility and Reward Sensitivity Following Nicotinic Receptor Stimulation in Dependent Smokers: A Randomized Trial.
Topics: Adult; Cerebral Cortex; Cross-Over Studies; Double-Blind Method; Executive Function; Female; Humans; Impulsive Behavior; Limbic System; Male; Motivation; Nicotine; Receptors, Nicotinic; Reversal Learning; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices; Tobacco Use Disorder; Varenicline | 2017 |
Nicotine Increases Activation to Anticipatory Valence Cues in Anterior Insula and Striatum.
Topics: Adolescent; Adult; Anticipation, Psychological; Cerebral Cortex; Corpus Striatum; Cross-Over Studies; Cues; Double-Blind Method; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nicotine; Reward; Smoking; Tobacco Use Disorder; Young Adult | 2018 |
A randomized clinical trial to evaluate the efficacy of contingency management for treatment of waterpipe tobacco addiction.
Topics: Adult; Behavior Therapy; Behavior, Addictive; Cotinine; Female; Humans; Indicators and Reagents; Male; Middle Aged; Nicotine; Reward; Saliva; Smoking Cessation; Substance Abuse Detection; Tobacco, Waterpipe; Treatment Outcome; Water Pipe Smoking | 2018 |
Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers.
Topics: Administration, Inhalation; Administration, Intravenous; Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electronic Nicotine Delivery Systems; Female; Flavoring Agents; Humans; Male; Menthol; Nicotine; Reward; Smokers; Smoking Cessation Agents; Young Adult | 2018 |
The acute effects of nicotine on corticostriatal responses to distinct phases of reward processing.
Topics: Adult; Female; Humans; Magnetic Resonance Imaging; Motivation; Nicotine; Nucleus Accumbens; Pregnancy; Reward; Tobacco Use Disorder; Young Adult | 2020 |
Effects of acute aerobic exercise on food-reward mechanisms in smoking-addicted individuals: An fNIRS study.
Topics: Exercise; Food; Humans; Magnetic Resonance Imaging; Nicotine; Prefrontal Cortex; Reward; Smoking | 2022 |
416 other study(ies) available for nicotine and s,n,n'-tripropylthiocarbamate
| Article | Year |
|---|---|
Mesolimbic dopamine and incentive properties of nicotine.
Topics: Dopamine; Humans; Limbic System; Nerve Endings; Neurons; Nicotine; Reward; Smoking | 1992 |
Human avoidance responding with added point loss: effects of tobacco and abstinence.
Topics: Adult; Avoidance Learning; Carbon Monoxide; Chewing Gum; Chromatography, Gas; Cotinine; Humans; Male; Nicotine; Reinforcement Schedule; Reward; Smoking; Smoking Cessation; Spirometry | 1992 |
Effects of nicotine on the threshold for rewarding brain stimulation in rats.
Topics: Animals; Brain; Electric Stimulation; Male; Mecamylamine; Naloxone; Nicotine; Rats; Rats, Inbred F344; Reward; Self Stimulation | 1992 |
5HT3 receptor antagonists block morphine- and nicotine- but not amphetamine-induced reward.
Topics: Amphetamine; Animals; Conditioning, Operant; Indoles; Male; Morphine; Nicotine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reward; Serotonin Antagonists; Tropanes; Tropisetron | 1989 |
Nicotine as a discriminative stimulus: a neurobehavioral approach to studying central cholinergic mechanisms.
Topics: Animals; Arecoline; Arousal; Brain; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Stimulus; Humans; Mental Recall; Mice; Models, Biological; Nicotine; Psychotropic Drugs; Rats; Receptors, Nicotinic; Reinforcement Schedule; Reticular Formation; Reward; Smoking | 1989 |
Behavioral pharmacology of licit drugs in experimental animals.
Topics: Animals; Caffeine; Conditioning, Psychological; Cotinine; Dogs; Nicotine; Rats; Reward; Saimiri | 1986 |
Cigarette dependence. I. Nature and classification.
Topics: Adolescent; Humans; Nicotine; Reward; Smoking; Social Behavior; Substance Withdrawal Syndrome; Substance-Related Disorders | 1971 |
The modification by physostigmine of some effects of nicotine on bar-pressing behaviour of rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Drug Synergism; Injections, Subcutaneous; Male; Neostigmine; Nicotine; Physostigmine; Rats; Reward | 1968 |
Effects of nicotine on operant behaviour of rats.
Topics: Amphetamine; Animals; Behavior, Animal; Conditioning, Operant; Conditioning, Psychological; Male; Nicotine; Rats; Reaction Time; Reward | 1967 |
Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation.
Topics: Animals; Benzamides; Benzazepines; Clozapine; Corpus Striatum; Dizocilpine Maleate; Gene Expression Regulation; Genes, fos; Glutamates; Glutamic Acid; Male; Mecamylamine; Nicotine; Nucleus Accumbens; Piperazines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Reward | 1994 |
Nicotine and brain-stimulation reward: interactions with morphine, amphetamine and pimozide.
Topics: Amphetamine; Animals; Brain; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Medial Forebrain Bundle; Morphine; Nicotine; Pimozide; Rats; Rats, Inbred F344; Reward; Self Stimulation | 1993 |
The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmission.
Topics: Animals; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Hypothalamus; Male; Nicotine; Ondansetron; Rats; Receptors, Serotonin; Reward; Self Stimulation; Serotonin Antagonists; Synaptic Transmission | 1993 |
Both nicotinic and muscarinic receptors in ventral tegmental area contribute to brain-stimulation reward.
Topics: Animals; Atropine; Dihydro-beta-Erythroidine; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Reward; Self Stimulation; Ventral Tegmental Area | 1997 |
Elementary particles for models of drug dependence, 10th Okey Memorial Lecture presented at the Institute of Psychiatry, London on 19th March 1997.
Topics: Animals; Behavior, Addictive; Brain; Cues; Discrimination, Psychological; Disease Models, Animal; Humans; Models, Psychological; Nicotine; Rats; Reward; Self Medication; Substance-Related Disorders; Terminology as Topic; Tobacco Use Disorder | 1997 |
Blockade of the reward-potentiating effects of nicotine on lateral hypothalamic brain stimulation by chlorisondamine.
Topics: Animals; Brain Mapping; Chlorisondamine; Drug Synergism; Electric Stimulation; Ganglionic Stimulants; Hypothalamic Area, Lateral; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Inbred Strains; Reward | 1998 |
The influence of smoking on reward responsiveness and cognitive functions: a natural experiment.
Topics: Adult; Choice Behavior; Cognition; Humans; Islam; Male; Nicotine; Psychomotor Performance; Reward; Smoking; Verbal Behavior | 1997 |
Elementary particles for models of drug dependence 10th Okey Memorial Lecture presented at the Institute of Psychiatry, London on 19th March 1997.
Topics: Animals; Behavior, Addictive; Brain; Cues; Discrimination, Psychological; Disease Models, Animal; Humans; Models, Psychological; Nicotine; Rats; Reward; Self Medication; Substance-Related Disorders; Terminology as Topic; Tobacco Use Disorder | 1998 |
Dramatic decreases in brain reward function during nicotine withdrawal.
Topics: Animals; Brain; Dihydro-beta-Erythroidine; Disease Models, Animal; Infusion Pumps, Implantable; Male; Motivation; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Stimulation; Sensory Thresholds; Substance Withdrawal Syndrome | 1998 |
Nicotine addiction and the lure of reward.
Topics: Animals; Brain; Cartoons as Topic; Humans; Nicotine; Reward; Self Stimulation; Substance Withdrawal Syndrome; Substance-Related Disorders | 1998 |
Food restriction enhances the central rewarding effect of abused drugs.
Topics: Amphetamine; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Energy Intake; Excitatory Amino Acid Antagonists; Food Deprivation; Locomotion; Male; Nicotine; Nicotinic Agonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Substance-Related Disorders; Sympathomimetics | 1998 |
Effect of chronic nicotine on brain stimulation reward. I. Effect of daily injections.
Topics: Animals; Brain; Electric Stimulation; Electrodes, Implanted; Injections; Male; Nicotine; Nicotinic Agonists; Rats; Reward; Self Stimulation | 1998 |
Effect of chronic nicotine on brain stimulation reward. II. An escalating dose regimen.
Topics: Animals; Dose-Response Relationship, Drug; Electrodes, Implanted; Injections, Subcutaneous; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward; Self Stimulation | 1998 |
Periadolescent nicotine exposure reduces cocaine reward in adult mice.
Topics: Age Factors; Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Locomotion; Male; Mice; Mice, Inbred C57BL; Nicotine; Reinforcement, Psychology; Reward; Self Administration; Sensitivity and Specificity; Weight Gain | 1999 |
Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.
Topics: Animals; Brain; Chlorisondamine; Injections, Intraventricular; Male; Mecamylamine; Naloxone; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2000 |
7-Nitroindazole blocks nicotine-induced conditioned place preference but not LiCl-induced conditioned place aversion.
Topics: Animals; Avoidance Learning; Conditioning, Psychological; Dopamine; Drug Interactions; Enzyme Inhibitors; Indazoles; Limbic System; Male; Memory; Mice; Nicotine; Nicotinic Agonists; Nitric Oxide Synthase; Reward; Ventral Tegmental Area | 2000 |
Effects of methyllycaconitine (MLA), an alpha 7 nicotinic receptor antagonist, on nicotine- and cocaine-induced potentiation of brain stimulation reward.
Topics: Aconitine; Animals; Cocaine; Dopamine Uptake Inhibitors; Hypothalamic Area, Lateral; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Ventral Tegmental Area | 2000 |
Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged-Ring Compounds; Electrophysiology; Humans; In Vitro Techniques; Ligands; Male; Motor Activity; Nicotine; Nicotinic Agonists; Oocytes; Pyridines; Pyrrolidines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Self Administration; Spiro Compounds; Transfection; Xenopus laevis | 2000 |
Differential effects of response-contingent and response-independent nicotine in rats.
Topics: Animals; Conditioning, Operant; Corticosterone; Epinephrine; Male; Nicotine; Nicotinic Agonists; Norepinephrine; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reward; Self Administration | 2000 |
Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse.
Topics: Amphetamine; Animals; Behavior, Addictive; Cannabinoids; Cocaine; Dopamine Uptake Inhibitors; Male; Mice; Mice, Knockout; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Receptors, Cannabinoid; Receptors, Drug; Reward | 2001 |
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; Disease Models, Animal; Drug Combinations; Electric Stimulation; Fluoxetine; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Piperazines; Rats; Rats, Wistar; Reaction Time; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission; Tobacco Use Disorder | 2001 |
A common profile of prefrontal cortical activation following exposure to nicotine- or chocolate-associated contextual cues.
Topics: Animals; Behavior, Animal; Cacao; Candy; Cell Count; Conditioning, Psychological; Cues; Learning; Male; Motor Activity; Neural Pathways; Neuronal Plasticity; Neurons; Nicotine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Recurrence; Reward; Tobacco Use Disorder | 2001 |
The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat.
Topics: Aconitine; Animals; Behavior, Animal; Brain; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2001 |
Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine.
Topics: Amphetamine; Animals; Cocaine; Endorphins; Ethanol; Extracellular Space; Male; Microdialysis; Motivation; Nicotine; Nucleus Accumbens; Radioimmunoassay; Rats; Rats, Long-Evans; Reward; Synaptic Transmission | 2001 |
Rats prefer cocaine over nicotine in a two-lever self-administration choice test.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Infusion Pumps; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Self Administration; Tobacco Use Disorder | 2002 |
Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats.
Topics: Animals; Benzazepines; Brain; Bridged Bicyclo Compounds; Dihydro-beta-Erythroidine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Receptors, Metabotropic Glutamate; Receptors, Nicotinic; Reward; Salicylamides | 2002 |
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas.
Topics: Acetylcholinesterase; Action Potentials; Adolescent; Animals; Atropine; Cholinergic Antagonists; Cholinesterase Inhibitors; Dopamine; Electrophysiology; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Ganglionic Stimulants; Glutamic Acid; Humans; In Vitro Techniques; Insecticides; Mice; Muscarinic Antagonists; Neurons; Nicotine; Organothiophosphorus Compounds; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Smoking; Synaptic Transmission; Ventral Tegmental Area | 2002 |
Restricted daily access to water and voluntary nicotine oral consumption in mice: methodological issues and individual differences.
Topics: Animals; Corticosterone; Cotinine; Dose-Response Relationship, Drug; Individuality; Male; Mice; Motivation; Nicotine; Nicotinic Agonists; Regional Blood Flow; Reproducibility of Results; Reward; Risk Factors; Stress, Psychological; Sucrose; Taste; Water Deprivation | 2002 |
Cigarette smoking and attention to signals of reward and threat in the Stroop paradigm.
Topics: Adolescent; Adult; Analysis of Variance; Emotions; Female; Humans; Male; Motivation; Nicotine; Nicotinic Agonists; Reward; Smoking Prevention | 2002 |
Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Dose-Response Relationship, Drug; Male; Microinjections; Motivation; Motor Activity; Nicotine; Nicotinic Agonists; Pons; Rats; Rats, Wistar; Reward; Spatial Behavior; Stimulation, Chemical; Taste; Tegmentum Mesencephali; Ventral Tegmental Area | 2002 |
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Hot Temperature; Immersion; Male; Mecamylamine; Mice; Mice, Knockout; Motor Activity; Neural Pathways; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Reward; Substance Withdrawal Syndrome | 2002 |
Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Psychological; Locomotion; Mecamylamine; Mice; Mice, Knockout; Nicotine; Nicotinic Antagonists; Receptors, Opioid, mu; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2002 |
The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse.
Topics: Amphetamine; Animals; Behavior, Animal; Choice Behavior; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Illicit Drugs; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Narcotics; Nicotine; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward | 2003 |
Neural activation profile elicited by cues associated with the anxiogenic drug yohimbine differs from that observed for reward-paired cues.
Topics: Adrenergic alpha-Antagonists; Animals; Anxiety; Cacao; Conditioning, Operant; Cues; Environment; Genes, fos; Immunohistochemistry; Male; Morphine; Motor Activity; Narcotics; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward; Yohimbine | 2003 |
Potentiation of nicotine reward by alcohol.
Topics: Drug Synergism; Ethanol; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; Reward; Smoking | 2002 |
Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area.
Topics: Animals; Avoidance Learning; Conditioning, Psychological; Dopamine; Dopamine Antagonists; Flupenthixol; Limbic System; Male; Motivation; Nicotine; Nicotinic Agonists; Phenotype; Rats; Rats, Wistar; Receptors, Dopamine; Reward; Synaptic Transmission; Tobacco Use Disorder; Ventral Tegmental Area | 2003 |
PET studies of the influences of nicotine on neural systems in cigarette smokers.
Topics: Adult; Amygdala; Arousal; Brain; Female; Humans; Male; Middle Aged; Nicotine; Oxygen Radioisotopes; Regional Blood Flow; Reward; Smoking; Tomography, Emission-Computed; Water | 2003 |
The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor.
Topics: 2-Amino-5-phosphonovalerate; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Microinjections; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Ventral Tegmental Area | 2003 |
Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Bupropion; Drug Administration Schedule; Electric Stimulation; Male; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2003 |
Repeated nicotine exposure enhances reward-related learning in the rat.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Conditioning, Operant; Drug Administration Schedule; Extinction, Psychological; Learning; Male; Motor Activity; Nicotine; Nicotinic Agonists; Random Allocation; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Time Factors | 2003 |
Impact of nicotine withdrawal on novelty reward and related behaviors.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drug Interactions; Ganglionic Blockers; Ganglionic Stimulants; Male; Mecamylamine; Motor Activity; Nicotine; Rats; Reaction Time; Reward; Social Environment; Substance Withdrawal Syndrome; Time Factors | 2003 |
Effects of repeated withdrawal episodes, nicotine dose, and duration of nicotine exposure on the severity and duration of nicotine withdrawal in rats.
Topics: Animals; Central Nervous System Stimulants; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Infusion Pumps, Implantable; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Stimulation; Sensory Thresholds; Substance Withdrawal Syndrome | 2003 |
Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement.
Topics: Animals; Conditioning, Operant; Male; Nicotine; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Self Administration | 2003 |
Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats.
Topics: Animals; Bridged Bicyclo Compounds; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Nicotine; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Reward; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2003 |
Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat.
Topics: Animals; Baclofen; Cocaine; Dopamine; Dose-Response Relationship, Drug; Extracellular Fluid; GABA Agonists; GABA-B Receptor Agonists; Male; Microdialysis; Morphine; Neural Pathways; Nicotine; Nucleus Accumbens; Rats; Receptors, GABA-B; Reward; Substance-Related Disorders; Synaptic Transmission; Up-Regulation | 2003 |
Characterization of the effects of bupropion on the reinforcing properties of nicotine and food in rats.
Topics: Animals; Bupropion; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Eating; Feeding Behavior; Male; Nicotine; Rats; Rats, Wistar; Reinforcement, Psychology; Reward; Self Administration; Tobacco Use Disorder | 2003 |
Neonatal ethanol exposure produces a hyperalgesia that extends into adolescence, and is associated with increased analgesic and rewarding properties of nicotine in rats.
Topics: Analgesics; Animals; Animals, Newborn; Conditioning, Psychological; Ethanol; Female; Hyperalgesia; Injections, Subcutaneous; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Reaction Time; Reward; Time Factors | 2004 |
Delayed effects of nicotine on timing behavior in the rat.
Topics: Animals; Food; Male; Nicotine; Rats; Reward | 1960 |
Nicotine as a signal for the presence or absence of sucrose reward: a Pavlovian drug appetitive conditioning preparation in rats.
Topics: Animals; Appetitive Behavior; Association Learning; Conditioning, Classical; Dose-Response Relationship, Drug; Extinction, Psychological; Generalization, Psychological; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reward; Sucrose | 2004 |
Reward potentiation or behavioral activation? A comment on Donny et al.
Topics: Animals; Conditioning, Operant; Nicotine; Photic Stimulation; Rats; Reward | 2004 |
Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine.
Topics: Affective Symptoms; Amphetamine; Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Male; Nicotine; Rats; Rats, Wistar; Reward; Substance Withdrawal Syndrome | 2003 |
Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward; Tobacco Use Disorder | 2003 |
Nicotine amplifies reward-related dopamine signals in striatum.
Topics: Action Potentials; Animals; Corpus Striatum; Dopamine; Guinea Pigs; In Vitro Techniques; Nicotine; Reward | 2004 |
Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats.
Topics: Animals; Appetitive Behavior; Choice Behavior; Conditioning, Classical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Administration Schedule; Hexamethonium; Male; Mecamylamine; Naloxone; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reward | 2004 |
Calcium channel antagonists attenuate cross-sensitization to the rewarding and/or locomotor effects of nicotine, morphine and MK-801.
Topics: Animals; Calcium Channel Blockers; Conditioning, Operant; Dizocilpine Maleate; Drug Interactions; Ganglionic Stimulants; Male; Mice; Morphine; Motor Activity; Narcotics; Neuroprotective Agents; Nicotine; Rats; Rats, Wistar; Reward | 2004 |
The effects of nitric oxide on the acquisition and expression of nicotine-induced conditioned place preference in mice.
Topics: Animals; Arginine; Conditioning, Operant; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mecamylamine; Mice; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Reward; Tobacco Use Disorder; Vasodilator Agents | 2004 |
Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats.
Topics: Acetaldehyde; Adolescent; Age Factors; Aging; Animals; Brain; Brain Chemistry; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Nicotiana; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Self Administration; Tobacco Use Disorder | 2005 |
Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization.
Topics: Alkaloids; Animals; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Drug Tolerance; Leucine; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Nicotine; Point Mutation; Pyridines; Quinolizines; Receptors, Nicotinic; Reward; Serine; Tobacco Use Disorder; Up-Regulation | 2004 |
Influence of nicotine on brain reward systems: study of intracranial self-stimulation.
Topics: Animals; Brain; Injections, Intraventricular; Nicotine; Rats; Reward; Self Stimulation | 2004 |
Nicotine in alcohol deprivation increases alcohol operant self-administration during reinstatement.
Topics: Animals; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Ethanol; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reinforcement, Psychology; Reward; Self Administration; Substance Withdrawal Syndrome | 2004 |
Stimulus properties of nicotine, amphetamine, and chlordiazepoxide as positive features in a pavlovian appetitive discrimination task in rats.
Topics: Amphetamine; Animals; Appetitive Behavior; Brain; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Conditioning, Classical; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Generalization, Stimulus; Hypnotics and Sedatives; Illicit Drugs; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward; Substance-Related Disorders | 2005 |
Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene.
Topics: Analgesics; Animals; Conditioning, Classical; Dopamine; Enkephalins; Female; Hot Temperature; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Nicotine; Nucleus Accumbens; Opioid Peptides; Pain Measurement; Pain Threshold; Protein Precursors; Reward; Spatial Behavior; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2005 |
Reduced nicotine reward in obesity: cross-comparison in human and mouse.
Topics: Animals; Cyclic AMP; Female; Humans; Male; Mice; Nicotine; Obesity; Receptors, Cell Surface; Receptors, Leptin; Receptors, Opioid, mu; Reward; RNA, Messenger; Smoking; Ventral Tegmental Area | 2005 |
Involvement of the laterodorsal tegmental nucleus in the locomotor response to repeated nicotine administration.
Topics: Acetylcholine; Animals; Cholinergic Fibers; Dopamine; Male; Motor Activity; Neural Pathways; Neurons; Nicotine; Nicotinic Agonists; Pedunculopontine Tegmental Nucleus; Pons; Rats; Reward; Synaptic Transmission; Tegmentum Mesencephali; Ventral Tegmental Area | 2005 |
Mu-opioid receptor and CREB activation are required for nicotine reward.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Blotting, Northern; Blotting, Western; Brain; Cell Count; Cocaine; Conditioning, Operant; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Narcotic Antagonists; Neurons; Nicotine; Phosphorylation; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; Reward; RNA, Messenger; Time Factors; Tobacco Use Disorder | 2005 |
Periadolescent nicotine administration produces enduring changes in dendritic morphology of medium spiny neurons from nucleus accumbens.
Topics: Age Factors; Animals; Cell Shape; Dendrites; Disease Models, Animal; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Reward; Risk Factors; Sexual Maturation; Tobacco Use Disorder | 2005 |
[Rewarding property of nicotine and methamphetamine tested by conditioned place preference in rats: effect of chronic nicotine pretreatment].
Topics: Animals; Conditioning, Psychological; Male; Methamphetamine; Nicotine; Rats; Rats, Wistar; Reward; Tobacco Use Disorder | 2005 |
Craving nicotine: It's in the genes.
Topics: Animals; Drug Tolerance; Humans; Mice; Nicotine; Point Mutation; Receptors, Nicotinic; Reward; Smoking; Smoking Cessation; Tobacco Use Disorder | 2005 |
Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems.
Topics: Animals; Brain; Disease Models, Animal; Male; Nicotine; Rats; Rats, Wistar; Reward; Substance Withdrawal Syndrome; Substance-Related Disorders | 2005 |
The airway sensory impact of nicotine contributes to the conditioned reinforcing effects of individual puffs from cigarettes.
Topics: Adult; Analysis of Variance; Conditioning, Operant; Female; Ganglionic Stimulants; Heart Rate; Humans; Male; Middle Aged; Nicotine; Reinforcement, Psychology; Respiratory System; Reward; Smoking; Substance Withdrawal Syndrome; Surveys and Questionnaires | 2005 |
Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Dopamine; Electrodes, Implanted; Enzyme Inhibitors; GABA Agonists; GABA-B Receptor Agonists; Limbic System; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, GABA-B; Reward; Self Stimulation; Synaptic Transmission; Ventral Tegmental Area; Vigabatrin | 2005 |
Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats.
Topics: Animals; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Drug Administration Schedule; Drug Tolerance; Hypothalamus, Posterior; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Ventral Tegmental Area | 2005 |
Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.
Topics: Aconitine; Animals; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Design; Drug Evaluation, Preclinical; Electric Stimulation; Humans; Male; Molecular Structure; Nicotine; Nicotinic Antagonists; Nomifensine; Protein Binding; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Rubidium; Structure-Activity Relationship; Synaptosomes | 2005 |
Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats.
Topics: Age Factors; Animals; Arousal; Association Learning; Choice Behavior; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Injections, Intraperitoneal; Male; Motor Activity; Nicotine; Premedication; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Social Environment; Tobacco Use Disorder | 2006 |
Dorsal hippocampal muscarinic and nicotinic receptors are involved in mediating morphine reward.
Topics: Analysis of Variance; Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Mecamylamine; Morphine; Motor Activity; Muscarinic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Physostigmine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Reward | 2006 |
Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Dihydro-beta-Erythroidine; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reward; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2006 |
Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoamine Oxidase Inhibitors; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Self Administration | 2006 |
Nicotine place preference in the mouse: influences of prior handling, dose and strain and attenuation by nicotinic receptor antagonists.
Topics: Animals; Arousal; Choice Behavior; Conditioning, Operant; Handling, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Motivation; Nicotine; Nicotinic Antagonists; Reward; Social Environment; Species Specificity | 2006 |
Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats.
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hallucinogens; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward | 2006 |
Periadolescent and adult rats respond differently in tests measuring the rewarding and aversive effects of nicotine.
Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Choice Behavior; Conditioning, Psychological; Male; Motor Activity; Nicotine; Rats; Rats, Wistar; Reward; Taste; Tobacco Use Disorder | 2006 |
Effects of expectancy and abstinence on the neural response to smoking cues in cigarette smokers: an fMRI study.
Topics: Adult; Brain; Brain Mapping; Cognition; Cues; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Neural Pathways; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Photic Stimulation; Prefrontal Cortex; Reward; Smoking; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2006 |
Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction.
Topics: Age Factors; Animals; Behavior, Animal; Cotinine; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reward; Self Stimulation; Sensory Thresholds; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2006 |
Enhancing effects of nicotine and impairing effects of scopolamine on distinct aspects of performance in computerized attention and working memory tasks in marmoset monkeys.
Topics: Acetylcholine; Animals; Attention; Callithrix; Dose-Response Relationship, Drug; Female; Male; Memory; Motivation; Muscarinic Antagonists; N-Methylscopolamine; Nicotine; Nicotinic Agonists; Receptors, Muscarinic; Receptors, Nicotinic; Reinforcement Schedule; Reward; Scopolamine; Task Performance and Analysis | 2006 |
Effects of ethanol on nicotine-induced conditioned place preference in C57BL/6J mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Reward | 2006 |
Attenuation of nicotine-induced rewarding effects in A2A knockout mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Dopamine; Dose-Response Relationship, Drug; Mice; Mice, Knockout; Microdialysis; Motor Activity; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Receptor, Adenosine A2A; Reward; Substance Withdrawal Syndrome; Taste | 2006 |
Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli.
Topics: Administration, Oral; Animals; Behavior, Animal; Conditioning, Psychological; Exploratory Behavior; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Monoamine Oxidase; Motor Activity; Nicotine; Quinine; Reward; Saccharin; Self Administration | 2006 |
The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.
Topics: Analysis of Variance; Animals; Area Under Curve; Association Learning; Behavior, Animal; Brain; Conditioning, Operant; Cues; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nitriles; Rats; Rats, Long-Evans; Reward; Tetrahydroisoquinolines | 2006 |
Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats.
Topics: Animals; Behavior, Animal; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Reward; Self Administration; Substance Withdrawal Syndrome | 2007 |
Differential impact of pavlovian drug conditioned stimuli on in vivo dopamine transmission in the rat accumbens shell and core and in the prefrontal cortex.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Dopamine; Dose-Response Relationship, Drug; Male; Microdialysis; Morphine; Motivation; Narcotics; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Substance-Related Disorders; Time Factors | 2007 |
The role of nicotinic acetylcholine receptors in the primary reinforcing and reinforcement-enhancing effects of nicotine.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Photic Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Self Administration; Tobacco Use Disorder | 2007 |
Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats.
Topics: Amino Acids; Animals; Dose-Response Relationship, Drug; Drug Interactions; Eating; Excitatory Amino Acid Antagonists; Ganglionic Stimulants; Infusions, Intravenous; Injections, Intraperitoneal; Male; Nicotine; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Reward; Self Administration; Substance Withdrawal Syndrome; Time Factors; Xanthenes | 2007 |
The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1.
Topics: Acetylcholine; Analysis of Variance; Animals; Brain; Cells, Cultured; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Guanosine 5'-O-(3-Thiotriphosphate); Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Radioligand Assay; Receptor, PAR-1; Reward; Statistics, Nonparametric; Tissue Plasminogen Activator | 2006 |
GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation.
Topics: Animals; Blotting, Western; Conditioning, Operant; Cyclopentanes; GABA Modulators; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Pyrimidines; Rats; Rats, Wistar; Receptors, GABA-B; Reinforcement, Psychology; Reward | 2007 |
'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration.
Topics: Animals; Conditioning, Operant; Food; Infusions, Intravenous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Water | 2007 |
Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dopamine Antagonists; Dose-Response Relationship, Drug; Eating; Infusions, Intravenous; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nitriles; Rats; Rats, Long-Evans; Receptors, Dopamine D3; Reinforcement Schedule; Reward; Self Administration; Tetrahydroisoquinolines; Tobacco Use Disorder | 2007 |
Nicotine increases FosB expression within a subset of reward- and memory-related brain regions during both peri- and post-adolescence.
Topics: Age Factors; Animals; Brain; Dentate Gyrus; Memory; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reward; Time Factors; Tobacco Use Disorder; Up-Regulation | 2007 |
Tranylcypromine enhancement of nicotine self-administration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Benzazepines; Chromatography, High Pressure Liquid; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrochemistry; Half-Life; Male; Microdialysis; Monoamine Oxidase Inhibitors; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reward; Self Administration; Tranylcypromine | 2007 |
Acute nicotine enhances c-fos mRNA expression differentially in reward-related substrates of adolescent and adult rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Conditioning, Operant; Gene Expression Regulation; Genes, fos; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reward; RNA, Messenger | 2007 |
Nicotine dependence and reward differ between adolescent and adult male mice.
Topics: Age Factors; Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Mice, Inbred ICR; Nicotine; Reward; Rubidium; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2007 |
The interoceptive Pavlovian stimulus effects of caffeine.
Topics: Animals; Appetitive Behavior; Caffeine; Conditioning, Classical; Dextroamphetamine; Discrimination, Psychological; Male; Nicotine; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reward; Sucrose | 2007 |
Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Dopamine; Male; Microdialysis; Monoamine Oxidase Inhibitors; Nicotine; Nicotinic Agonists; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Reward; Self Administration; Tranylcypromine | 2007 |
CREB1 haplotypes and the relative reinforcing value of nicotine.
Topics: Association Learning; Case-Control Studies; Choice Behavior; Cyclic AMP Response Element-Binding Protein; Double-Blind Method; Haplotypes; Humans; Linkage Disequilibrium; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Polymorphism, Single Nucleotide; Receptors, Opioid, mu; Regression Analysis; Reward; Smoking; Tobacco Use Disorder | 2007 |
Metabotropic glutamate 2/3 receptor activation induced reward deficits but did not aggravate brain reward deficits associated with spontaneous nicotine withdrawal in rats.
Topics: Amino Acids; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Male; Nicotine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reward; Substance Withdrawal Syndrome | 2007 |
Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Choice Behavior; Conditioning, Operant; Disease Models, Animal; Impulsive Behavior; Male; Nicotine; Predictive Value of Tests; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Self Administration; Substance-Related Disorders | 2008 |
Changed accumbal responsiveness to alcohol in rats pre-treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Agonists; Central Nervous System Depressants; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Extracellular Fluid; Male; Microdialysis; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Reward; Up-Regulation | 2008 |
Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors.
Topics: Administration, Oral; Animals; Anxiety Disorders; Behavior, Animal; Brain; Cyclic AMP Response Element-Binding Protein; Depressive Disorder; Down-Regulation; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Neural Pathways; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Receptors, AMPA; Reward; Synaptic Transmission; Tobacco Use Disorder; Ventral Tegmental Area; Volition | 2008 |
Age-dependent differences in nicotine reward and withdrawal in female mice.
Topics: Aging; Animals; Anxiety; Body Temperature; Conditioning, Operant; Drug Tolerance; Female; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Pain Measurement; Reaction Time; Reinforcement Schedule; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala.
Topics: Amygdala; Animals; Blotting, Western; Catheterization; Electrodes, Implanted; Excitatory Postsynaptic Potentials; Feeding Behavior; Isoquinolines; Male; Nicotine; Nucleus Accumbens; Patch-Clamp Techniques; Prefrontal Cortex; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reward; Self Administration; Ventral Tegmental Area | 2009 |
The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat.
Topics: Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Depression; Desipramine; Food; Infusion Pumps, Implantable; Injections, Intravenous; Nicotine; Nicotinic Agonists; Rats; Reward; Self Administration; Self Stimulation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats.
Topics: Animals; Brain; GABA Modulators; GABA-B Receptor Agonists; Male; Nicotine; Rats; Rats, Wistar; Receptors, GABA-B; Reinforcement Schedule; Reward; Self Administration | 2008 |
The endogenous cannabinoid system modulates nicotine reward and dependence.
Topics: Animals; Cannabinoid Receptor Modulators; Conditioning, Psychological; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Signal Transduction; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways.
Topics: Analysis of Variance; Animals; Chemotaxis; DNA Primers; Ethanol; Gene Expression Regulation; Nicotine; Oligonucleotide Array Sequence Analysis; Reinforcement, Psychology; Reverse Transcriptase Polymerase Chain Reaction; Reward; Substance-Related Disorders; Zebrafish | 2008 |
Decreased brain reward function during nicotine withdrawal in C57BL6 mice: evidence from intracranial self-stimulation (ICSS) studies.
Topics: Animals; Brain; Drug Implants; Electrodes, Implanted; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reward; Self Stimulation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats.
Topics: Animals; Arginine; Brain; Drug Implants; Electric Stimulation; Electrodes, Implanted; Male; Neuropeptide Y; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Self Stimulation; Substance Withdrawal Syndrome | 2008 |
Enhanced vulnerability to the rewarding effects of nicotine during the adolescent period of development.
Topics: Aging; Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Environment; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reward | 2008 |
Long-lasting cognitive deficits resulting from adolescent nicotine exposure in rats.
Topics: Aging; Analysis of Variance; Animals; Attention; Choice Behavior; Cognition; Dopamine; Impulsive Behavior; Male; Nicotine; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Reaction Time; Reward | 2009 |
Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Bupropion; Conditioning, Psychological; Drug Administration Schedule; Electric Stimulation; Male; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2008 |
Nicotine-induced monoamine neurotransmitter changes in the brain of young rats.
Topics: Age Factors; Animals; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid; Dopamine; Hippocampus; Male; Microdialysis; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Norepinephrine; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reward; Septal Nuclei; Serotonin; Tegmentum Mesencephali; Temporal Lobe; Ventral Tegmental Area | 2008 |
Initial nicotine sensitivity in humans as a function of impulsivity.
Topics: Administration, Intranasal; Adult; Dose-Response Relationship, Drug; Extraversion, Psychological; Female; Humans; Impulsive Behavior; Male; Nicotine; Nicotinic Agonists; Reinforcement, Psychology; Reward; Sex Factors; Young Adult | 2008 |
Effect of forced chronic oral nicotine exposure on intravenous self-administration and rewarding properties of acute nicotine.
Topics: Administration, Oral; Animals; Animals, Outbred Strains; Conditioning, Operant; Injections, Intravenous; Male; Mice; Nicotine; Nicotinic Agonists; Reward; Self Administration; Tobacco Use Disorder | 2008 |
Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats.
Topics: Animals; Baclofen; Behavior, Animal; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward | 2008 |
Dopamine signaling through D1-like versus D2-like receptors in the nucleus accumbens core versus shell differentially modulates nicotine reward sensitivity.
Topics: Animals; Avoidance Learning; Catheterization; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Motivation; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; Signal Transduction; Substance Withdrawal Syndrome; Tegmentum Mesencephali; Tissue Distribution | 2008 |
Association of retrospective early smoking experiences with prospective sensitivity to nicotine via nasal spray in nonsmokers.
Topics: Administration, Intranasal; Affect; Central Nervous System Stimulants; Emotions; Female; Humans; Male; Nicotine; Prognosis; Prospective Studies; Reinforcement, Psychology; Retrospective Studies; Reward; Smoking; Surveys and Questionnaires; Tobacco Use Disorder; Young Adult | 2008 |
Rewarding and aversive effects of nicotine are segregated within the nucleus accumbens.
Topics: Animals; Avoidance Learning; Choice Behavior; Conditioning, Psychological; Dopamine; Injections, Intravenous; Injections, Subcutaneous; Male; Nicotine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Long-Evans; Reward; Spatial Behavior; Synaptic Transmission; Taste | 2008 |
Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Conditioning, Psychological; Dopamine; Endocannabinoids; Hydrolysis; Male; Motor Activity; Nicotine; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reward; Self Administration; Tobacco Use Disorder | 2008 |
Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Male; Medial Forebrain Bundle; Motivation; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reward; Running; Self Stimulation | 2008 |
Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking.
Topics: Administration, Intranasal; Adult; Affect; Blood Pressure; Conditioning, Eyelid; Dose-Response Relationship, Drug; Drug Tolerance; Education; Ethnicity; Female; Heart Rate; Humans; Male; Marital Status; Nicotine; Nicotinic Agonists; Parents; Psychomotor Performance; Reward; Risk Assessment; Sex Factors; Smoking; Socioeconomic Factors; Substance-Related Disorders; Young Adult | 2009 |
Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats.
Topics: Aminopyridines; Amphetamine; Animals; Conditioning, Operant; Dopamine Agents; Dose-Response Relationship, Drug; Indoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Motor Activity; Nicotine; Nicotinic Agonists; Pyrazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists | 2009 |
Propranolol transiently inhibits reinstatement of nicotine-seeking behaviour in rats.
Topics: Adrenergic beta-Antagonists; Animals; Behavior, Addictive; Disease Models, Animal; Extinction, Psychological; Feeding Behavior; Male; Nicotine; Nicotinic Agonists; Propranolol; Rats; Rats, Sprague-Dawley; Reward; Secondary Prevention; Self Administration; Smoking; Smoking Prevention | 2010 |
Occasion setting by drug states: Functional equivalence following similar training history.
Topics: Amphetamine; Animals; Association Learning; Behavior, Animal; Central Nervous System Stimulants; Chlordiazepoxide; Conditioning, Classical; Discrimination Learning; Extinction, Psychological; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward; Substance-Related Disorders; Sucrose | 2008 |
Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzazepines; Brain; Bupropion; Dopamine; Dose-Response Relationship, Drug; Drugs, Investigational; Male; Neurons; Nicotine; Nicotinic Antagonists; Picolines; Quaternary Ammonium Compounds; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Smoking Cessation; Structure-Activity Relationship; Tobacco Use Disorder; Varenicline; Ventral Tegmental Area | 2009 |
The role of nicotine in smoking: a dual-reinforcement model.
Topics: Animals; Association Learning; Conditioning, Psychological; Cues; Disease Models, Animal; Ganglionic Stimulants; Humans; Motivation; Nicotine; Rats; Reward; Self Administration; Smoking; Smoking Cessation; Social Environment; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2009 |
Insular hypocretin transmission regulates nicotine reward.
Topics: Animals; Benzoxazoles; Cerebral Cortex; Intracellular Signaling Peptides and Proteins; Male; Motivation; Naphthyridines; Neuropeptides; Nicotine; Nicotinic Agonists; Orexin Receptors; Orexins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reward; Self Administration; Smoking; Synaptic Transmission; Tobacco Use Disorder; Urea | 2008 |
Nicotinic acetylcholine alpha4beta2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method.
Topics: Aconitine; Animals; Behavior, Animal; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electric Stimulation; Male; Medial Forebrain Bundle; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Running; Self Stimulation | 2008 |
Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning.
Topics: Animals; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Dopamine; gamma-Aminobutyric Acid; Gene Expression Regulation; Locomotion; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Nicotinic Agonists; Phosphorylation; Presynaptic Terminals; Receptors, Nicotinic; Reward; Synaptosomes; Tobacco Use Disorder; Ventral Tegmental Area | 2009 |
Nicotine exposure during adolescence induces a depression-like state in adulthood.
Topics: Aging; Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Cholinergic Agents; Depression; Emotions; Fluoxetine; Food Preferences; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Stress, Psychological; Weight Gain | 2009 |
Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects.
Topics: Animals; Dopamine; Dopamine Antagonists; Electrophysiology; Flupenthixol; Limbic System; Male; Mecamylamine; Microinjections; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Reinforcement, Psychology; Reward; Synaptic Transmission; Ventral Tegmental Area | 2009 |
Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference.
Topics: Animals; Conditioning, Psychological; Cues; Cyclic AMP Response Element-Binding Protein; Decision Making; Dose-Response Relationship, Drug; Down-Regulation; Gene Transfer Techniques; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Phosphorylation; Reward; Synaptic Transmission; Tobacco Use Disorder; Up-Regulation | 2009 |
Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse.
Topics: Animals; Benzenesulfonates; Brain; Corticotropin-Releasing Hormone; Extinction, Psychological; Food; Injections, Intraventricular; Male; Nicotine; Peptide Fragments; Psychomotor Performance; Quinolines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Recurrence; Reward; Self Stimulation; Stress, Psychological; Substance Withdrawal Syndrome | 2009 |
Synergistic interaction between nicotine and social rewards in adolescent male rats.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Infusions, Intravenous; Interpersonal Relations; Male; Nicotine; Nicotinic Agonists; Play and Playthings; Rats; Rats, Sprague-Dawley; Reward; Social Environment | 2009 |
Patterns of change in withdrawal symptoms, desire to smoke, reward motivation and response inhibition across 3 months of smoking abstinence.
Topics: Adolescent; Adult; Aged; Female; Humans; Inhibition, Psychological; London; Male; Middle Aged; Motivation; Nicotine; Reward; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Time Factors; Tobacco Use Disorder; Young Adult | 2009 |
Enhanced nicotine sensitivity in nociceptin/orphanin FQ receptor knockout mice.
Topics: Animals; Anxiety; Drug Tolerance; Hypothermia; Male; Maze Learning; Mice; Mice, Knockout; Motor Activity; Nicotine; Nociceptin Receptor; Receptors, Opioid; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2009 |
Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin.
Topics: Animals; Anxiety; beta-Endorphin; Conditioning, Classical; Crosses, Genetic; Exploratory Behavior; Female; Hyperkinesis; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Antagonists; Pain Measurement; Pro-Opiomelanocortin; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2009 |
Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of alpha4beta2 nicotinic receptors in rats.
Topics: Animals; Benzazepines; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Medial Forebrain Bundle; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Rats; Rats, Long-Evans; Receptors, Nicotinic; Reward; Varenicline | 2009 |
Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats.
Topics: Animals; Antibodies, Monoclonal; Brain; Dose-Response Relationship, Drug; Immunization, Passive; Immunoglobulin G; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reward; Self Stimulation; Stereotaxic Techniques; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2009 |
Enhanced nicotine reward in adulthood after exposure to nicotine during early adolescence in mice.
Topics: Age Factors; Animals; Brain; Conditioning, Psychological; Male; Mice; Mice, Inbred ICR; Neurons; Nicotine; Receptors, Nicotinic; Reward; Tobacco Use Disorder | 2009 |
Female rats display dose-dependent differences to the rewarding and aversive effects of nicotine in an age-, hormone-, and sex-dependent manner.
Topics: Age Factors; Amphetamine; Animals; Animals, Newborn; Avoidance Learning; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Estrous Cycle; Female; Hormones; Male; Nicotine; Nicotinic Agonists; Ovariectomy; Rats; Rats, Wistar; Reward; Sex Characteristics | 2009 |
The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal.
Topics: Animals; Anxiety; Avoidance Learning; Body Temperature; Calcium Channel Blockers; Conditioning, Operant; Conotoxins; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Reaction Time; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2009 |
Route of nicotine administration influences in vivo dopamine neuron activity: habituation, needle injection, and cannula infusion.
Topics: Action Potentials; Animals; Brain; Catheterization; Cues; Dopamine; Drug Administration Routes; Extracellular Fluid; Infusion Pumps; Injections; Male; Microdialysis; Needles; Neurons; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Long-Evans; Reward; Substance-Related Disorders; Tobacco Use Disorder; Ventral Tegmental Area | 2010 |
Delay of smoking gratification as a laboratory model of relapse: effects of incentives for not smoking, and relationship with measures of executive function.
Topics: Adolescent; Executive Function; Extinction, Psychological; Female; Humans; Impulsive Behavior; Male; Motivation; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Predictive Value of Tests; Reaction Time; Regression Analysis; Reward; Self Administration; Smoking; Smoking Cessation; Time Factors; Young Adult | 2009 |
Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Bupropion; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mecamylamine; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Time Factors | 2009 |
Adolescent male Wistar rats are more responsive than adult rats to the conditioned rewarding effects of intravenously administered nicotine in the place conditioning procedure.
Topics: Age Factors; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Stimulants; Choice Behavior; Conditioning, Psychological; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Motivation; Motor Activity; Nicotine; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Self Administration | 2010 |
Effect of administration of the nicotinic acetylcholine receptor antagonist BTMPS, during nicotine self-administration, on lever responding induced by context long after withdrawal.
Topics: Animals; Behavior, Animal; Body Weight; Conditioning, Operant; Decanoic Acids; Dose-Response Relationship, Drug; Feeding Behavior; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Piperidines; Psychomotor Performance; Rats; Rats, Wistar; Reward; Self Administration; Space Perception; Time Factors; Tobacco Use Cessation | 2010 |
Isolating behavioral mechanisms of intertemporal choice: nicotine effects on delay discounting and amount sensitivity.
Topics: Animals; Choice Behavior; Conditioning, Operant; Impulsive Behavior; Male; Nicotine; Rats; Rats, Long-Evans; Reinforcement Schedule; Reward | 2009 |
Orexin and leptin are associated with nicotine craving: a link between smoking, appetite and reward.
Topics: Adolescent; Adult; Aged; Appetite; Behavior, Addictive; Case-Control Studies; Female; Humans; Intracellular Signaling Peptides and Proteins; Leptin; Male; Middle Aged; Motivation; Neuropeptides; Nicotine; Orexins; Reward; Smoking; Substance Withdrawal Syndrome; Surveys and Questionnaires; Tobacco Use Disorder; Young Adult | 2010 |
Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Administration Schedule; Flupenthixol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motivation; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine D2; Reward; Signal Transduction; Tobacco Use Disorder | 2010 |
Possible testable correlations between passive smoking and bipolar/cyclothymic disorder, depression and ADD/ADHD.
Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Depression; Humans; Models, Psychological; Nicotine; Reward; Tobacco Smoke Pollution | 2010 |
Nicotinic modulation of auditory attentional shift in the rat.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Atropine; Attention; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reaction Time; Reward; Signal Detection, Psychological | 2010 |
Preadolescent tobacco smoke exposure leads to acute nicotine dependence but does not affect the rewarding effects of nicotine or nicotine withdrawal in adulthood in rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Body Weight; Cotinine; Electric Stimulation; Environmental Exposure; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reaction Time; Reward; Self Stimulation; Sexual Maturation; Substance Withdrawal Syndrome; Time Factors; Tobacco Smoke Pollution; Tobacco Use Disorder | 2010 |
Effects of varenicline and mecamylamine on the acquisition, expression, and reinstatement of nicotine-conditioned place preference by drug priming in rats.
Topics: Animals; Benzazepines; Conditioning, Classical; Dose-Response Relationship, Drug; Male; Mecamylamine; Morphine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Tobacco Use Disorder; Varenicline | 2010 |
Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse.
Topics: Analgesics; Animals; Anxiety; Buprenorphine; Dose-Response Relationship, Drug; Hyperalgesia; Hypothermia; Male; Mice; Morphine; Nicotine; Piperidines; Receptors, Opioid, kappa; Reward; Substance Withdrawal Syndrome; Tetrahydroisoquinolines | 2010 |
Nicotinic acetylcholine receptors of the dorsal hippocampus and the basolateral amygdala are involved in ethanol-induced conditioned place preference.
Topics: Amygdala; Animals; CA1 Region, Hippocampal; Conditioning, Classical; Ethanol; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Reward | 2010 |
Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cocaine; Dopamine; Evoked Potentials; Male; Morphine; Neurons; Nicotine; Nucleus Accumbens; PPAR alpha; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reward; Ventral Tegmental Area | 2010 |
Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.
Topics: Animals; Azetidines; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethanol; Male; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Reward; Saccharin; Self Administration | 2010 |
Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats.
Topics: Amphetamine; Animals; Body Weight; Central Nervous System Stimulants; Conditioning, Operant; Depression; Drinking; Eating; Interpersonal Relations; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Substance Withdrawal Syndrome; Sucrose; Weight Gain | 2010 |
Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice.
Topics: Animals; Anxiety; Behavior, Animal; Bupropion; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Emotions; Hydroxylation; Hyperalgesia; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2010 |
The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Animals; Brain; Dihydro-beta-Erythroidine; Electrodes, Implanted; Fluorobenzenes; Ganglionic Stimulants; Idazoxan; Male; Nicotine; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Serotonin Antagonists; Substance Withdrawal Syndrome | 2010 |
Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Propranolol; Rats; Rats, Wistar; Reaction Time; Reinforcement, Psychology; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2010 |
Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
Topics: Action Potentials; Animals; Behavior, Animal; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Indoles; Male; Microdialysis; Neurons; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Oligosaccharides; Peroxisome Proliferators; PPAR alpha; Pyrimidines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Saimiri; Self Administration; Ventral Tegmental Area | 2011 |
Stress alleviation and reward enhancement: two promising targets for relapse prevention.
Topics: Animals; Drug Delivery Systems; Humans; Nicotine; Reward; Secondary Prevention; Stress, Psychological; Tobacco Use Disorder | 2010 |
NICO-TEEN: neural substrates that mediate adolescent tobacco abuse.
Topics: Adolescent; Aging; Dopamine; Humans; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Ventral Tegmental Area | 2011 |
Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference.
Topics: Animals; Cocaine; Conditioning, Psychological; Galanin; Male; Mice; Mice, 129 Strain; Mice, Congenic; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Morphine; Nicotine; Nucleus Accumbens; Phosphorylation; Reward; Signal Transduction; Synaptic Transmission | 2011 |
Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine.
Topics: Aging; Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Female; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nicotine; Nucleus Accumbens; Reward; Sex Characteristics; Species Specificity | 2011 |
Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats.
Topics: Animals; Benzoates; Depression; Drug Synergism; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Male; Nicotine; Phosphinic Acids; Pyrimidines; Rats; Rats, Wistar; Receptors, GABA-B; Reward; Self Stimulation; Substance Withdrawal Syndrome | 2011 |
Habenular α5 nicotinic receptor subunit signalling controls nicotine intake.
Topics: Animals; Female; Habenula; Male; Mice; Mice, Knockout; Nicotine; Rats; Receptors, Nicotinic; Reward; Signal Transduction; Tobacco Use Disorder | 2011 |
Direct effect of nicotine on mesolimbic dopamine release in rat nucleus accumbens shell.
Topics: Animals; Disease Models, Animal; Dopamine; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reward; Tobacco Use Disorder | 2011 |
Nicotine and the behavioral mechanisms of intertemporal choice.
Topics: Analysis of Variance; Animals; Choice Behavior; Conditioning, Operant; Dose-Response Relationship, Drug; Impulsive Behavior; Male; Motivation; Nicotine; Rats; Rats, Long-Evans; Reinforcement Schedule; Reward | 2011 |
Nicotine alters limbic function in adolescent rat by a 5-HT1A receptor mechanism.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Catecholamines; Dopamine Agonists; Drug Administration Schedule; Drug Interactions; Gene Expression Regulation; Limbic System; Locomotion; Male; Nicotine; Nicotinic Agonists; Piperazines; Protein Binding; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Reward; RNA, Messenger; Self Administration; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Time Factors | 2011 |
The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.
Topics: Animals; Arachidonic Acids; Behavior, Addictive; Behavior, Animal; Conditioning, Psychological; Dopamine; Dronabinol; Endocannabinoids; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Reward | 2012 |
The effects of repeated exposure on the reward-enhancing effects of nicotine.
Topics: Acoustic Stimulation; Animals; Conditioning, Operant; Data Interpretation, Statistical; Discrimination Learning; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reward | 2011 |
Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats.
Topics: Animals; Behavior, Animal; Benzazepines; Dose-Response Relationship, Drug; Female; Food; Motivation; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Reward; Self Administration; Serotonin 5-HT2 Receptor Agonists; Smoking Cessation; Tobacco Use Disorder | 2011 |
Discounting of hypothetical and potentially real outcomes in nicotine-dependent and nondependent samples.
Topics: Choice Behavior; Female; Humans; Impulsive Behavior; Male; Nicotine; Outcome Assessment, Health Care; Probability; Reward; Smoking; Substance-Related Disorders; Time Factors; Tobacco Use Disorder | 2011 |
Exploring behavioral and molecular mechanisms of nicotine reward in adolescent mice.
Topics: Aging; Animals; Brain; Cell Membrane; Conditioning, Operant; Dopamine; Exploratory Behavior; Male; Mice; Mice, Inbred ICR; Nicotine; Protein Binding; Receptors, Nicotinic; Reward | 2011 |
Cannabinoid CB1 receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats.
Topics: Animals; Avoidance Learning; Conditioning, Operant; Male; Memory; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant | 2011 |
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Receptors, Nicotinic; Reward; Synaptosomes; Tritium | 2011 |
The role of conditioning history and reinforcer strength in the reinforcement enhancing effects of nicotine in rats.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward; Sucrose | 2012 |
Nicotine self-administered directly into the VTA by rats is weakly reinforcing but has strong reinforcement enhancing properties.
Topics: Animals; Carbachol; Cholinergic Agonists; Dopamine; Male; Neurons; Nicotine; Nicotinic Agonists; Photic Stimulation; Rats; Reinforcement, Psychology; Reward; Self Administration; Ventral Tegmental Area | 2012 |
Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Dopamine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Microdialysis; Neurons; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Self Administration; Time Factors; Ventral Tegmental Area | 2012 |
Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens.
Topics: Animals; Conditioning, Classical; Dopamine; Dopamine Agents; Female; Ganglionic Stimulants; Gene Expression; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nucleus Accumbens; Protein Kinase C-epsilon; Receptors, Nicotinic; Reward; RNA, Messenger; Self Administration; Signal Transduction; Space Perception | 2011 |
Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.
Topics: Anhedonia; Animals; Brain; Cocaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward; Self Stimulation; Substance Withdrawal Syndrome; Time Factors | 2012 |
Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Amygdala; Animals; Benzenesulfonates; Clonidine; Electrodes, Implanted; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Quinolines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2012 |
Anhedonia predicts altered processing of happy faces in abstinent cigarette smokers.
Topics: Adult; Anhedonia; Attention; Cognition Disorders; Cues; Facial Expression; Female; Happiness; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Reward; Smoking; Smoking Cessation; Surveys and Questionnaires | 2012 |
Intravenous gestational nicotine exposure results in increased motivation for sucrose reward in adult rat offspring.
Topics: Animals; Conditioning, Operant; Female; Male; Motivation; Motor Activity; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward; Sucrose | 2012 |
Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings.
Topics: Action Potentials; Animals; Clofibrate; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Hypolipidemic Agents; Indoles; Male; Neurons; Nicotine; Nucleus Accumbens; PPAR alpha; Rats; Rats, Sprague-Dawley; Reward; Saimiri; Secondary Prevention; Self Administration; Tobacco Use Disorder; Ventral Tegmental Area | 2012 |
Pharmacological characterization of 50-kHz ultrasonic vocalizations in rats: comparison of the effects of different psychoactive drugs and relevance in drug-induced reward.
Topics: Animals; Central Nervous System Stimulants; Male; Methylphenidate; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Reward; Vocalization, Animal | 2012 |
Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Molecular Structure; Nicotine; Nicotinic Antagonists; Pyridines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Nicotinic; Reward; Self Administration; Self Stimulation; Species Specificity | 2012 |
Influence of δ-opioid receptors in the behavioral effects of nicotine.
Topics: Animals; Behavior, Animal; Dopamine; Male; Mice; Mice, Knockout; Microdialysis; Motor Activity; Nicotine; Nicotinic Agonists; Nociception; Receptors, Opioid, delta; Reward | 2012 |
Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost-benefit decision making tasks in rats.
Topics: Animals; Atropine; Choice Behavior; Cost-Benefit Analysis; Decision Making; Dose-Response Relationship, Drug; Male; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Probability; Rats; Rats, Long-Evans; Reward; Scopolamine | 2012 |
Sex differences in yohimbine-induced increases in the reinforcing efficacy of nicotine in adolescent rats.
Topics: Adolescent; Adrenergic alpha-2 Receptor Antagonists; Adult; Age Factors; Analysis of Variance; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Infusions, Intravenous; Male; Nicotine; Nicotinic Agonists; Rats; Reinforcement Schedule; Reinforcement, Psychology; Reward; Self Administration; Sex Characteristics; Stress, Psychological; Tobacco Use Disorder; Yohimbine | 2014 |
Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice.
Topics: Analysis of Variance; Animals; Brain; Conditioning, Operant; Electric Stimulation; Mecamylamine; Mice; Microelectrodes; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Up-Regulation | 2012 |
Reinstatement of methamphetamine conditioned place preference in nicotine-sensitized rats.
Topics: Analysis of Variance; Animals; Central Nervous System Sensitization; Central Nervous System Stimulants; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Methamphetamine; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward; Time Factors | 2012 |
A quantitative analysis of the reward-enhancing effects of nicotine using reinforcer demand.
Topics: Animals; Conditioning, Operant; Male; Models, Theoretical; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward; Self Administration; Time Factors | 2012 |
The effect of nicotine on sign-tracking and goal-tracking in a Pavlovian conditioned approach paradigm in rats.
Topics: Animals; Attention; Conditioning, Classical; Goals; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward | 2013 |
The effect of previous exposure to nicotine on nicotine place preference.
Topics: Animals; Conditioning, Psychological; Injections, Subcutaneous; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Time Factors | 2013 |
Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake.
Topics: Animals; Avoidance Learning; Brain; Cocaine; Corpus Striatum; Dopamine; Dynorphins; G-Protein-Coupled Receptor Kinase 3; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microinjections; Naltrexone; Narcotic Antagonists; Nicotine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Raphe Nuclei; Receptors, Opioid, kappa; Reward; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Stress, Psychological; Substance Withdrawal Syndrome; Synaptosomes | 2012 |
Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout mice.
Topics: Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Cocaine; Female; Haplotypes; Humans; Linkage Disequilibrium; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nucleus Accumbens; Phenotype; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2012 |
Nicotine addiction reduces the large-conductance Ca(2+)-activated potassium channels expression in the nucleus accumbens.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Conditioning, Classical; Down-Regulation; Drug-Seeking Behavior; Exploratory Behavior; Gene Expression Regulation; Ion Transport; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Nicotine; Nucleus Accumbens; Patch-Clamp Techniques; Potassium; Reward; RNA, Small Interfering; Tobacco Use Disorder | 2013 |
From occasional choices to inevitable musts: a computational model of nicotine addiction.
Topics: Behavior, Addictive; Brain; Choice Behavior; Computer Simulation; Decision Making; Learning; Models, Neurological; Models, Psychological; Neurons; Nicotine; Reward | 2012 |
Prior exposure to THC increases the addictive effects of nicotine in rats.
Topics: Animals; Behavior, Addictive; Cannabinoid Receptor Agonists; Conditioning, Operant; Dronabinol; Drug Synergism; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Reinforcement Schedule; Reward; Self Administration | 2013 |
Effects of acute and sub-chronic nicotine on impulsive choice in rats in a probabilistic delay-discounting task.
Topics: Animals; Behavior, Animal; Choice Behavior; Conditioning, Operant; Impulsive Behavior; Male; Nicotine; Probability; Rats; Rats, Long-Evans; Reaction Time; Reinforcement Schedule; Reward; Time Factors | 2013 |
Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.
Topics: Age Factors; Animals; Behavior, Animal; Benzazepines; Butanones; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chemotaxis; Chlorides; Fasting; Mecamylamine; Muscles; Mutation; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Subunits; Quinoxalines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Nicotinic; Reward; Sodium; Taste; Time Factors; Varenicline | 2013 |
The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse.
Topics: Animals; Conotoxins; Dose-Response Relationship, Drug; Male; Mice; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2013 |
A preliminary study suggests that nicotine and prefrontal dopamine affect cortico-striatal areas in smokers with performance feedback.
Topics: Adult; Catechol O-Methyltransferase; Corpus Striatum; Dopamine; Feedback, Psychological; Female; Heterozygote; Homozygote; Humans; Magnetic Resonance Imaging; Male; Nicotine; Prefrontal Cortex; Reward; Smoking; Tobacco Use Cessation Devices | 2013 |
Reinforcement enhancing effects of nicotine via smoking.
Topics: Female; Humans; Male; Nicotine; Reinforcement, Psychology; Reward; Smoking; Tobacco Use Disorder | 2013 |
Effects of the beta-lactam antibiotic ceftriaxone on nicotine withdrawal and nicotine-induced reinstatement of preference in mice.
Topics: Amino Acid Transport Systems; Animals; Anti-Bacterial Agents; Ceftriaxone; Conditioning, Psychological; Cysteine; Excitatory Amino Acid Transporter 2; Extinction, Psychological; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Nicotine; Reinforcement, Psychology; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
Nicotine-, tobacco particulate matter- and methamphetamine-produced locomotor sensitisation in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Male; Methamphetamine; Motor Activity; Nicotiana; Nicotine; Particulate Matter; Rats; Rats, Sprague-Dawley; Reward; Smoke | 2013 |
The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice.
Topics: Animals; Anisoles; Behavior, Animal; Cocaine; Conditioning, Psychological; Cyclohexanols; Dose-Response Relationship, Drug; Female; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Receptor, Cannabinoid, CB2; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
Cholinergic control over attention in rats prone to attribute incentive salience to reward cues.
Topics: Acetylcholine; Amphetamine; Animals; Attention; Cholinergic Agonists; Conditioning, Classical; Cues; Dopamine Uptake Inhibitors; Female; Male; Microdialysis; Motivation; Nicotine; Principal Component Analysis; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reward; Time Factors; Video Recording | 2013 |
The histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Male; Mice; Mice, Knockout; Nerve Tissue Proteins; Nicotine; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine.
Topics: Animals; Conditioning, Operant; Male; Mice; Mice, Knockout; Nicotine; Nucleus Accumbens; Receptor, Cannabinoid, CB2; Reinforcement, Psychology; Reward; Self Administration; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2013 |
Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes.
Topics: Animals; Blood Glucose; Conditioning, Operant; Diabetes Mellitus, Experimental; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Infusions, Intravenous; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats, Wistar; Reinforcement, Psychology; Reward; Self Administration | 2014 |
Stimulation of nicotine reward and central cholinergic activity in Sprague-Dawley rats exposed perinatally to a fat-rich diet.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Brain; Conditioning, Operant; Diet, High-Fat; Female; Male; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement Schedule; Reward; Self Administration; Signal Transduction | 2013 |
Age-dependent alterations in reward-seeking behavior after brief nicotine exposure.
Topics: Aging; Animals; Appetitive Behavior; Catheters, Indwelling; Cocaine; Conditioning, Operant; Dietary Sucrose; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Male; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Reward; Self Administration | 2014 |
Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Behavior, Animal; Body Temperature; Conditioning, Operant; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Half-Life; Immersion; Male; Mice; Mice, Knockout; Nicotine; Nicotinic Agonists; Pain Measurement; Reaction Time; Reward; Steroid Hydroxylases | 2013 |
Baseline impulsive choice predicts the effects of nicotine and nicotine withdrawal on impulsivity in rats.
Topics: Analysis of Variance; Animals; Choice Behavior; Conditioning, Operant; Drug Delivery Systems; Impulsive Behavior; Male; Nicotine; Predictive Value of Tests; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Self Administration; Time Factors; Tobacco Use Disorder | 2014 |
Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Anorexia; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reinforcement Schedule; Reward; Self Administration | 2013 |
The glucagon-like peptide 1 analogue Exendin-4 attenuates the nicotine-induced locomotor stimulation, accumbal dopamine release, conditioned place preference as well as the expression of locomotor sensitization in mice.
Topics: Animals; Conditioning, Psychological; Dopamine; Eating; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Incretins; Limbic System; Male; Mice; Motor Activity; Nicotine; Nucleus Accumbens; Peptides; Receptors, Glucagon; Reward; Tobacco Use Disorder; Venoms | 2013 |
Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Classical; Gene Regulatory Networks; Genetic Variation; Mice; Mice, Inbred C57BL; Nicotine; Nucleus Accumbens; Phenotype; Quantitative Trait Loci; Quinuclidines; Reward; RNA, Messenger | 2014 |
Exposure to nicotine enhances its subsequent self-administration: contribution of nicotine-associated contextual stimuli.
Topics: Animals; Conditioning, Operant; Cues; Discrimination, Psychological; Drug-Seeking Behavior; Housing, Animal; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Rats, Long-Evans; Reinforcement Schedule; Reward; Self Administration; Space Perception; Time Factors | 2014 |
Juvenile play experience does not affect nicotine sensitization and voluntary consumption of nicotine in adult rats.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Female; Motor Activity; Nicotine; Play and Playthings; Rats; Reward; Self Administration | 2014 |
Initial responses to the first dose of nicotine in novel smokers: the role of exposure to environmental smoking and genetic predisposition.
Topics: Adolescent; Cross-Sectional Studies; Environmental Exposure; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Male; Netherlands; Nicotine; Parents; Peer Group; Polymorphism, Genetic; Receptors, Dopamine D2; Receptors, Opioid, mu; Reward; Smoking; Tobacco Use Disorder | 2014 |
Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations.
Topics: Animals; Anxiety; Avoidance Learning; Baclofen; Conditioning, Psychological; GABA-B Receptor Agonists; Male; Mice; Movement; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Receptors, GABA-B; Reward; Space Perception; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2014 |
Anhedonia in obsessive-compulsive disorder: beyond comorbid depression.
Topics: Adolescent; Adult; Anhedonia; Comorbidity; Depression; Female; Humans; Male; Middle Aged; Nicotine; Obsessive-Compulsive Disorder; Pleasure; Prevalence; Reward; Smoking; Substance-Related Disorders; Surveys and Questionnaires; Young Adult | 2014 |
Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement.
Topics: Animals; Central Nervous System Agents; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Eating; Male; Motivation; Motor Activity; Nicotine; Nicotinic Agonists; Orexin Receptor Antagonists; Orexin Receptors; Rats, Long-Evans; Reinforcement Schedule; Reward; Self Administration; Tobacco Use Disorder | 2014 |
Tobacco particulate matter self-administration in rats: differential effects of tobacco type.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug-Seeking Behavior; Male; Motivation; Nicotiana; Nicotine; Nicotinic Agonists; Particulate Matter; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Self Administration; Tobacco Use Disorder | 2015 |
Sustained AAV-mediated overexpression of CRF in the central amygdala diminishes the depressive-like state associated with nicotine withdrawal.
Topics: Animals; Behavior, Animal; Central Amygdaloid Nucleus; Corticotropin-Releasing Hormone; Dependovirus; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Reward; Self Stimulation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2014 |
Insulin resistant rats display enhanced rewarding effects of nicotine.
Topics: Animals; Blood Glucose; Body Weight; Conditioning, Operant; Cues; Diet; Insulin Resistance; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward | 2014 |
Behavioral and neural substrates of habit formation in rats intravenously self-administering nicotine.
Topics: Administration, Intravenous; Animals; Brain; Cell Count; Emetics; Extinction, Psychological; Habits; Immunohistochemistry; Lithium Compounds; Male; Nicotine; Nicotinic Agonists; Photomicrography; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Reward; Self Administration | 2014 |
Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
Topics: Animals; Anxiety; Aryl Hydrocarbon Hydroxylases; Conditioning, Psychological; Cytochrome P450 Family 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Male; Mecamylamine; Methoxsalen; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reward; Severity of Illness Index; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2014 |
Dopamine receptor blockade modulates the rewarding and aversive properties of nicotine via dissociable neuronal activity patterns in the nucleus accumbens.
Topics: Action Potentials; Animals; Avoidance Learning; Conditioning, Psychological; Dopamine Antagonists; Flupenthixol; Male; Neural Inhibition; Neurons; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Random Allocation; Rats, Sprague-Dawley; Receptors, Dopamine; Reward; Spatial Behavior | 2014 |
Adolescent nicotine or cigarette smoke exposure changes subsequent response to nicotine conditioned place preference and self-administration.
Topics: Aging; Animals; Catheters, Indwelling; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Reward; Self Administration; Smoking; Spatial Behavior; Tobacco Use Disorder | 2014 |
Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice.
Topics: Animals; Avoidance Learning; Cocaine; Conditioning, Psychological; Conotoxins; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Food; Lithium Chloride; Male; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Reward; Spatial Behavior | 2015 |
Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice.
Topics: Anhedonia; Animals; Gene Deletion; Male; Mecamylamine; Mice; Mice, Knockout; Microinjections; Nicotine; Receptors, Nicotinic; Reward; Self Stimulation; Substance Withdrawal Syndrome | 2015 |
Administration of the nicotinic acetylcholine receptor agonists ABT-089 and ABT-107 attenuates the reinstatement of nicotine-seeking behavior in rats.
Topics: Analysis of Variance; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Indoles; Male; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward; Self Administration; Sucrose | 2014 |
Sensory reinforcement-enhancing effects of nicotine via smoking.
Topics: Adolescent; Adult; Behavior, Addictive; Breath Tests; Carbon Monoxide; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Male; Nicotine; Nicotinic Agonists; Pennsylvania; Reinforcement, Psychology; Reward; Sensation; Smoking; Task Performance and Analysis; Tobacco Use Disorder; Young Adult | 2014 |
Quantifying nicotine's value-enhancement effect using a behavioral economic approach.
Topics: Animals; Conditioning, Operant; Economics, Behavioral; Extinction, Psychological; Food; Male; Nicotine; Rats, Long-Evans; Reinforcement, Psychology; Reward | 2014 |
Nicotine increases impulsivity and decreases willingness to exert cognitive effort despite improving attention in "slacker" rats: insights into cholinergic regulation of cost/benefit decision making.
Topics: Animals; Attention; Cholinergic Antagonists; Cognition; Decision Making; Impulsive Behavior; Male; Mecamylamine; Nicotine; Oxotremorine; Rats; Rats, Long-Evans; Reward; Scopolamine | 2014 |
Mu Opioid Receptor Binding Correlates with Nicotine Dependence and Reward in Smokers.
Topics: Adult; Biomarkers; Brain; Carbon Radioisotopes; Female; Fentanyl; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Opioid, mu; Reward; Self Report; Severity of Illness Index; Smoking; Tobacco Use Disorder; Young Adult | 2014 |
Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways.
Topics: Amphetamine; Animals; Behavior, Animal; Choice Behavior; Decision Making; Gambling; Male; Mecamylamine; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Oxotremorine; Rats; Rats, Long-Evans; Reward; Scopolamine | 2015 |
Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in rats.
Topics: Animals; Brain; Brain Mapping; Cerebrovascular Circulation; Compulsive Behavior; Dose-Response Relationship, Drug; Magnetic Resonance Imaging; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxygen; Rats, Wistar; Reward | 2014 |
Selective lesions of the cholinergic neurons within the posterior pedunculopontine do not alter operant learning or nicotine sensitization.
Topics: Animals; Cholinergic Neurons; Conditioning, Operant; Habituation, Psychophysiologic; Male; Motor Activity; Nicotine; Nicotinic Agonists; Pedunculopontine Tegmental Nucleus; Rats; Reinforcement Schedule; Reward | 2016 |
Belief about nicotine selectively modulates value and reward prediction error signals in smokers.
Topics: Adult; Attention; Choice Behavior; Culture; Female; Humans; Magnetic Resonance Imaging; Male; Neurons; Nicotine; Placebos; Reward; Smoking; Visual Perception | 2015 |
Nicotine enhances the locomotor stimulating but not the conditioned rewarding effect of ethanol in DBA/2J mice.
Topics: Animals; Conditioning, Psychological; Drug Synergism; Ethanol; Male; Mice; Mice, Inbred DBA; Motor Activity; Nicotine; Reward | 2015 |
Revisiting the effect of nicotine on interval timing.
Topics: Animals; Appetitive Behavior; Male; Mecamylamine; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Reward; Time Perception | 2015 |
Beliefs modulate the effects of drugs on the human brain.
Topics: Culture; Female; Humans; Male; Nicotine; Reward; Smoking | 2015 |
Reward Anticipation Is Differentially Modulated by Varenicline and Nicotine in Smokers.
Topics: Adolescent; Adult; Brain; Case-Control Studies; Cross-Over Studies; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Motivation; Nicotine; Nicotinic Agonists; Oxygen; Reaction Time; Reward; Smoking; Varenicline; Young Adult | 2015 |
Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse.
Topics: Animals; Benzamides; Biphenyl Compounds; Brain; Carbamates; Cues; Dopamine; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Male; Mixed Function Oxygenases; Models, Animal; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Recurrence; Reward; Saimiri; Self Administration; Time Factors | 2015 |
The effects of nicotine dependence and acute abstinence on the processing of drug and non-drug rewards.
Topics: Carbon Monoxide; Choice Behavior; Craving; Cross-Over Studies; Depression; Female; Humans; Male; Motivation; Nicotine; Pleasure; Psychomotor Performance; Reading; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Young Adult | 2015 |
Examination of the metabolite hydroxybupropion in the reinforcing and aversive stimulus effects of nicotine in rats.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Bupropion; Male; Nicotine; Rats; Receptors, Nicotinic; Reward; Self Administration; Smoking Cessation; Tobacco Use Disorder | 2015 |
Rewarding smoking cessation in pregnancy-will women cheat to gain incentives?
Topics: Female; Humans; Motivation; Nicotine; Pregnancy; Reward; Smoking; Smoking Cessation | 2015 |
The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine.
Topics: Aminopyridines; Animals; Benzazepines; Dorsal Raphe Nucleus; Dose-Response Relationship, Drug; Indoles; Male; Medial Forebrain Bundle; Nicotine; Nicotinic Agonists; Rats, Long-Evans; Receptor, Serotonin, 5-HT2C; Reward; Self Stimulation; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists | 2015 |
Behavioral effects of phencyclidine on nicotine self-administration and reinstatement in the presence or absence of a visual stimulus in rats.
Topics: Animals; Behavior, Animal; Cues; Excitatory Amino Acid Antagonists; Extinction, Psychological; Male; Nicotine; Phencyclidine; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Yohimbine | 2015 |
Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking.
Topics: Alcohol Drinking; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Depressants; Compulsive Behavior; Conditioning, Operant; Disease Models, Animal; Ethanol; Glutamate Decarboxylase; Male; Nicotine; Nicotinic Agonists; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-fos; Quinine; Rats; Rats, Wistar; Reward; Self Administration; Time Factors | 2015 |
Effects of combined nicotine and fluoxetine treatment on adult hippocampal neurogenesis and conditioned place preference.
Topics: Animals; Conditioning, Psychological; Dentate Gyrus; Drug Interactions; Fluoxetine; Histone Deacetylase 2; Male; Nerve Tissue Proteins; Neurogenesis; Neurons; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Reward; Selective Serotonin Reuptake Inhibitors; Spatial Behavior | 2015 |
Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward.
Topics: Action Potentials; Animals; Bacterial Proteins; Calbindin 2; Calbindins; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; GABAergic Neurons; Glutamate Decarboxylase; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Receptors, Nicotinic; Reward; Tyrosine 3-Monooxygenase; Up-Regulation; Ventral Tegmental Area | 2015 |
Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring.
Topics: Age Factors; Animals; Anxiety; Body Weight; Brain; Diet; Dopamine; Eating; Exploratory Behavior; Female; Food Preferences; Male; Maze Learning; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Dopamine D2; Reward; Statistics, Nonparametric | 2015 |
Reinforcement enhancing effects of acute nicotine via electronic cigarettes.
Topics: Adult; Electronic Nicotine Delivery Systems; Female; Humans; Male; Nicotine; Reinforcement, Psychology; Reward; Smoking | 2015 |
Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats.
Topics: Animals; Brain; Indoles; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Pyrrolidines; Rats, Wistar; Receptors, Vasopressin; Reward; Self Stimulation; Substance Withdrawal Syndrome | 2015 |
Cigarette smoke exposure during adolescence enhances sensitivity to the rewarding effects of nicotine in adulthood, even after a long period of abstinence.
Topics: Aging; Animals; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Motivation; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Reward; Self Administration; Spatial Behavior; Tobacco Smoke Pollution; Tobacco Use Disorder | 2015 |
The effects of environmental enrichment on nicotine condition place preference in male rats.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Environment; Extinction, Psychological; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Social Isolation | 2015 |
Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats.
Topics: Anesthetics, Local; Animals; Conditioning, Psychological; Diazepam; Dopaminergic Neurons; Ketamine; Lidocaine; Male; Nicotine; Rats; Rats, Wistar; Reward; Ventral Tegmental Area | 2015 |
Adolescent nicotine exposure fails to impact cocaine reward, aversion and self-administration in adult male rats.
Topics: Age Factors; Animals; Avoidance Learning; Cocaine; Dose-Response Relationship, Drug; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Self Administration | 2015 |
Effect of a D3 receptor antagonist on context-induced reinstatement of nicotine seeking.
Topics: Animals; Conditioning, Operant; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Food; Nicotine; Nicotinic Agonists; Nitriles; Rats, Sprague-Dawley; Receptors, Dopamine D3; Reward; Self Administration; Spatial Behavior; Tetrahydroisoquinolines; Tobacco Use Disorder | 2016 |
Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Conditioning, Psychological; Food; Male; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Nicotinic Agonists; Reward; Spatial Behavior | 2016 |
Co-administration of ethanol and nicotine: the enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Drug Combinations; Ethanol; Female; Glutamic Acid; Limbic System; Nicotine; Nucleus Accumbens; Rats; Reward; Self Administration | 2015 |
Rats quit nicotine for a sweet reward following an extensive history of nicotine use.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Choice Behavior; Disease Models, Animal; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Saccharin; Sweetening Agents | 2017 |
Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice.
Topics: Alcohol Drinking; Animals; Dopamine; Dopaminergic Neurons; Ethanol; Female; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Reward; Up-Regulation | 2016 |
Effects of the phencyclidine model of schizophrenia and nicotine on total and categorized ultrasonic vocalizations in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Male; Nicotine; Phencyclidine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Schizophrenia; Smoking; Ultrasonics; Vocalization, Animal | 2016 |
N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice.
Topics: Acetylcysteine; Animals; Association Learning; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2016 |
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reinforcement, Psychology; Reward; Rimonabant; Saimiri; Self Administration | 2016 |
Early adolescent nicotine exposure affects later-life cocaine reward in mice.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Eating; Male; Mice; Mice, Inbred ICR; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Reward | 2016 |
Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward.
Topics: Acetylcholine; Action Potentials; Animals; Cell Line, Tumor; Cells, Cultured; Conditioning, Operant; Dopaminergic Neurons; Exocytosis; Luminescent Proteins; Menthol; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroblastoma; Nicotine; Nicotinic Agonists; Protein Subunits; Receptors, Nicotinic; Reward; Time Factors; Up-Regulation | 2016 |
Age differences in conditioned place preferences and taste aversions to nicotine.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Cotinine; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward; Taste | 2016 |
Estradiol promotes the rewarding effects of nicotine in female rats.
Topics: Animals; Animals, Newborn; Conditioning, Operant; Dose-Response Relationship, Drug; Estradiol; Female; Male; Nicotine; Nicotinic Agonists; Ovariectomy; Rats; Rats, Wistar; Reward; Self Administration; Sex Characteristics | 2016 |
Nicotine-dopamine-transporter interactions during reward-based decision making.
Topics: Adult; Corpus Striatum; Decision Making; Dopamine; Dopamine Plasma Membrane Transport Proteins; Extracellular Space; Gambling; Humans; Male; Nicotine; Nicotinic Agonists; Psychomotor Performance; Reward; Risk-Taking; Synaptic Transmission; Tobacco Use Cessation Devices; Tomography, Emission-Computed, Single-Photon; Young Adult | 2016 |
Potential sex differences in the pattern of sensory reinforcers enhanced by nicotine.
Topics: Adult; Female; Humans; Male; Music; Nicotine; Reinforcement, Psychology; Reward; Sex Factors; Smoking; Tobacco Use Disorder; Young Adult | 2016 |
The tendency to sign-track predicts cue-induced reinstatement during nicotine self-administration, and is enhanced by nicotine but not ethanol.
Topics: Animals; Central Nervous System Depressants; Conditioning, Classical; Cues; Drug-Seeking Behavior; Ethanol; Food; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Self Administration | 2016 |
Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Dopamine; Exploratory Behavior; Hippocampus; Male; Mesencephalon; Mice; Mice, Knockout; Microdialysis; Nicotine; Nicotinic Agonists; Polymorphism, Single Nucleotide; Receptors, Nicotinic; Reward; Serotonin; Tobacco Use Disorder; Ventral Tegmental Area | 2016 |
The impact of flavoring on the rewarding and reinforcing value of e-cigarettes with nicotine among young adult smokers.
Topics: Adult; Choice Behavior; Electronic Nicotine Delivery Systems; Female; Flavoring Agents; Humans; Male; Motivation; Nicotine; Reinforcement, Psychology; Reward; Smoking; Vaping; Young Adult | 2016 |
Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway.
Topics: Animals; Brain; Brain Mapping; Dopamine; Enkephalins; Gene Expression; Motivation; Motor Activity; Nerve Net; Nicotine; Nociceptin Receptor; Nucleus Accumbens; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa; Reward; RNA, Messenger; Tobacco Use Disorder | 2016 |
Immediate early gene expression reveals interactions between social and nicotine rewards on brain activity in adolescent male rats.
Topics: Aging; Animals; Brain; Conditioning, Psychological; Extinction, Psychological; Gene Expression; Genes, Immediate-Early; Male; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Reward; Social Behavior; Social Environment | 2016 |
A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.
Topics: Adolescent; Alleles; Animals; Female; Germany; Humans; Male; Mice; Nicotine; Nicotinic Agonists; Receptors, Opioid, mu; Reinforcement, Psychology; Reward; Self Administration; Sex Factors; Tobacco Use Disorder; Young Adult | 2016 |
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
Topics: Animals; Anxiety; Corticotropin-Releasing Hormone; Dependovirus; Disease Models, Animal; Genetic Vectors; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Nicotinic; Reward; Self Stimulation; Septal Nuclei; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2016 |
Sex differences and the role of dopamine receptors in the reward-enhancing effects of nicotine and bupropion.
Topics: Animals; Bupropion; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Male; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Reward; Sex Characteristics | 2017 |
Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283.
Topics: Allosteric Regulation; Animals; Behavior, Animal; Drug-Seeking Behavior; Male; Nicotine; Nicotinic Agonists; Oxadiazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Self Administration | 2017 |
CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers.
Topics: Adult; Brain Mapping; Choice Behavior; Cytochrome P-450 CYP2A6; Executive Function; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Neural Pathways; Nicotine; Reward; Smoking; Tobacco Use Disorder; Ventral Striatum | 2017 |
Effects of maternal separation on nicotine-induced conditioned place preference and subsequent learning and memory in adolescent female rats.
Topics: Aging; Animals; Behavior, Animal; Cognition; Female; Learning; Maternal Deprivation; Memory; Motor Activity; Nicotine; Rats, Wistar; Reward | 2017 |
Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers.
Topics: Adolescent; Adult; Affect; Anticipation, Psychological; Association Learning; Caudate Nucleus; Cerebral Cortex; Cues; Female; Frontal Lobe; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nicotine; Nicotinic Agonists; Oxygen; Reaction Time; Reward; Smoking; Young Adult | 2017 |
Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors.
Topics: Action Potentials; Alcohols; Animals; Dopaminergic Neurons; Mice; Nerve Tissue Proteins; Nicotine; Receptors, Nicotinic; Reward | 2017 |
Both nicotine reward and withdrawal are enhanced in a rodent model of diabetes.
Topics: Animals; Conditioning, Psychological; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Rodentia; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2017 |
GLP-1 acts on habenular avoidance circuits to control nicotine intake.
Topics: Animals; Avoidance Learning; Exenatide; Female; Gene Knockdown Techniques; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Habenula; Interpeduncular Nucleus; Male; Mice; Mice, Knockout; Neural Pathways; Nicotine; Peptides; Rats; Reward; Self Stimulation; Sitagliptin Phosphate; Solitary Nucleus; Venoms | 2017 |
Nicotine Withdrawal Induces Neural Deficits in Reward Processing.
Topics: Adult; Brain; Electroencephalography; Female; Humans; Male; Middle Aged; Nicotine; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Young Adult | 2017 |
Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability.
Topics: Action Potentials; Animals; Cell Line; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Synergism; Menthol; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Organ Culture Techniques; Receptors, Nicotinic; Reward; Up-Regulation | 2017 |
Brain nicotinic acetylcholine receptors are involved in stress-induced potentiation of nicotine reward in rats.
Topics: Animals; Basolateral Nuclear Complex; Behavior, Animal; CA1 Region, Hippocampal; Conditioning, Classical; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Stress, Psychological | 2017 |
Habitual nicotine-seeking in rats following limited training.
Topics: Animals; Conditioning, Operant; Drug-Seeking Behavior; Extinction, Psychological; Lithium Chloride; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Saccharin; Self Administration | 2017 |
Dorsal-CA1 Hippocampal Neuronal Ensembles Encode Nicotine-Reward Contextual Associations.
Topics: Animals; Behavior, Animal; CA1 Region, Hippocampal; Male; Memory; Mice; Nicotine; Reward | 2017 |
Selective Inhibition of Amygdala Neuronal Ensembles Encoding Nicotine-Associated Memories Inhibits Nicotine Preference and Relapse.
Topics: Amygdala; Animals; Conditioning, Classical; Conditioning, Operant; Extinction, Psychological; Gene Expression Regulation; Male; Memory; Neural Inhibition; Neurons; Nicotine; Nicotinic Agonists; Oncogene Proteins v-fos; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Reward; RNA, Messenger; Self Administration | 2017 |
Effects of ceftriaxone on conditioned nicotine reward in rats.
Topics: Animals; Ceftriaxone; Conditioning, Classical; Conditioning, Psychological; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reward; Smoking; Smoking Cessation; Tobacco Use Disorder | 2017 |
Individual and combined effects of cannabis and tobacco on drug reward processing in non-dependent users.
Topics: Adult; Behavior, Addictive; Craving; Cross-Over Studies; Double-Blind Method; Dronabinol; Drug Synergism; Female; Humans; Male; Marijuana Abuse; Marijuana Smoking; Motivation; Nicotine; Reaction Time; Reward; Smoking; Tobacco Use Disorder; Young Adult | 2017 |
Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain.
Topics: Animals; Dopaminergic Neurons; Drug-Seeking Behavior; Female; Gene Deletion; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Nicotine; Receptors, Nicotinic; Reward; Synaptic Potentials; Ventral Tegmental Area | 2017 |
The effects of nicotine on conditioning, extinction, and reinstatement in humans.
Topics: Adult; Candy; Conditioning, Psychological; Connecticut; Extinction, Psychological; Female; Ganglionic Stimulants; Humans; Male; Nicotine; Reward; Students; Tobacco Use Disorder; Universities | 2018 |
Maternal undernutrition during lactation alters nicotine reward and DOPAC/dopamine ratio in cerebral cortex in adolescent mice, but does not affect nicotine-induced nAChRs upregulation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Cerebral Cortex; Conditioning, Operant; Dopamine; Female; Male; Malnutrition; Mice; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Receptors, Nicotinic; Reward; Up-Regulation | 2018 |
Nicotine-induced CREB and DeltaFosB activity is modified by caffeine in the brain reward system of the rat.
Topics: Animals; Brain; Caffeine; Central Nervous System Stimulants; Cyclic AMP Response Element-Binding Protein; Male; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Reward | 2018 |
Retrograde inhibition by a specific subset of interpeduncular α5 nicotinic neurons regulates nicotine preference.
Topics: Animals; Female; Gene Expression Profiling; Gene Expression Regulation; Habenula; Interpeduncular Nucleus; Male; Mice; Mice, Transgenic; Neurons; Neurotransmitter Agents; Nicotine; Nitric Oxide; Nitric Oxide Synthase Type I; Protein Biosynthesis; Protein Isoforms; Receptors, Nicotinic; Reward; RNA, Small Interfering; Somatostatin; Stereotaxic Techniques; Synaptic Transmission; Tobacco Use Disorder | 2017 |
Suppressive and enhancing effects of nicotine on food-seeking behavior.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Male; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Reward; Self Administration | 2018 |
Exercise improves nicotine reward-associated cognitive behaviors and related α7 nAChR-mediated signal transduction in adolescent rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cigarette Smoking; Cognition; Cognitive Dysfunction; Ganglionic Stimulants; Hippocampus; Male; Maze Learning; Nicotine; Physical Conditioning, Animal; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reward; Signal Transduction | 2018 |
Chronic nicotine exposure impairs uncertainty modulation on reinforcement learning in anterior cingulate cortex and serotonin system.
Topics: Animals; Behavior, Animal; Connectome; Decision Making; Executive Function; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Nicotine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reinforcement, Psychology; Reward; Smokers; Uncertainty | 2018 |
Effects of nicotine self-administration on incentive salience in male Sprague Dawley rats.
Topics: Animals; Conditioning, Classical; Cues; Male; Motivation; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Self Administration | 2018 |
Evaluation of the rewarding properties of nicotine and caffeine by implementation of a five-choice conditioned place preference task in zebrafish.
Topics: Acetylation; Animals; Caffeine; Central Nervous System Stimulants; Choice Behavior; Conditioning, Classical; Histone Deacetylase Inhibitors; Histones; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Phenylbutyrates; Reward; Spatial Behavior; Zebrafish | 2018 |
Reinforcement Enhancing Effects of Nicotine Via Patch and Nasal Spray.
Topics: Adult; Female; Humans; Male; Nasal Sprays; Nicotine; Reinforcement, Psychology; Reward; Smoking; Smoking Cessation; Smoking Prevention; Tobacco Use Cessation Devices | 2019 |
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.
Topics: Animals; Brain Injuries, Traumatic; Cerebral Cortex; Conditioning, Classical; Glycine; Male; Mecamylamine; Mice; Nicotine; Oleic Acids; Oxazoles; PPAR alpha; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2019 |
Clozapine reduces nicotine self-administration, blunts reinstatement of nicotine-seeking but increases responding for food.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Conditioning, Operant; Drug-Seeking Behavior; Food; Haloperidol; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Reward; Self Administration | 2019 |
The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity.
Topics: Adolescent; Adult; Brain; Female; Humans; Male; Middle Aged; Motivation; Nicotiana; Nicotine; Nicotinic Agonists; Reward; Severity of Illness Index; Smoking; Tobacco Use Disorder; Young Adult | 2019 |
Attentional capacities prior to drug exposure predict motivation to self-administer nicotine.
Topics: Animals; Attention; Conditioning, Operant; Cues; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Reinforcement, Psychology; Reward; Self Administration | 2018 |
Insulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabetes.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Conditioning, Psychological; Diabetes Mellitus, Experimental; Female; Glucosides; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Nicotine; Nicotinic Agonists; Reward | 2018 |
Increased expression of CRF and CRF-receptors in dorsal striatum, hippocampus, and prefrontal cortex after the development of nicotine sensitization in rats.
Topics: Animals; Central Nervous System Sensitization; Corpus Striatum; Corticotropin-Releasing Hormone; Hippocampus; Locomotion; Male; Nicotine; Prefrontal Cortex; Rats; Receptors, Corticotropin-Releasing Hormone; Reward | 2018 |
New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice.
Topics: Animals; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Reward; Smoking Cessation Agents; Substance Withdrawal Syndrome; Tobacco Use Disorder; Varenicline | 2018 |
c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo.
Topics: Animals; Autonomic Nervous System; Cocaine; Dopamine Uptake Inhibitors; Dopaminergic Neurons; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Reward; Substance Withdrawal Syndrome; Transcriptional Activation; Ventral Tegmental Area | 2018 |
Differential effects of withdrawal from intermittent and continuous nicotine exposure on reward deficit and somatic aspects of nicotine withdrawal and expression of α4β2* nAChRs in Wistar male rats.
Topics: Animals; Autoantigens; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Infusion Pumps, Implantable; Iodine Radioisotopes; Limbic Lobe; Male; Nicotine; Nucleus Accumbens; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome; Up-Regulation; Ventral Tegmental Area | 2018 |
Nicotine and varenicline ameliorate changes in reward-based choice strategy and altered decision-making in methamphetamine-treated rats.
Topics: Animals; Central Nervous System Stimulants; Conditioning, Operant; Decision Making; Dose-Response Relationship, Drug; Male; Methamphetamine; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Reward; Risk-Taking; Time Factors; Varenicline | 2019 |
Nicotine aversion is mediated by GABAergic interpeduncular nucleus inputs to laterodorsal tegmentum.
Topics: Animals; Avoidance Learning; Channelrhodopsins; Electrodes, Implanted; GABAergic Neurons; Gene Expression; Habenula; Interpeduncular Nucleus; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Nicotine; Optogenetics; Reward; Stereotaxic Techniques; Synapses; Tegmentum Mesencephali; Transgenes | 2018 |
Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice.
Topics: Animals; Hippocampus; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Receptors, Opioid, mu; Reward; Risk Factors | 2018 |
Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors.
Topics: Action Potentials; Animals; Cell Line; Dopaminergic Neurons; Light; Mesencephalon; Mice, Inbred C57BL; Nicotine; Receptors, Nicotinic; Reward; Signal Transduction; Ventral Tegmental Area | 2018 |
The effect of nicotine and nicotine+monoamine oxidase inhibitor on the value of alcohol.
Topics: Alcohol Drinking; Animals; Behavior, Addictive; Conditioning, Operant; Ethanol; Male; Monoamine Oxidase Inhibitors; Nicotine; Rats; Rats, Long-Evans; Reinforcement, Psychology; Reward; Self Administration; Tranylcypromine | 2019 |
Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward.
Topics: Amidohydrolases; Animals; Brain; Conditioning, Psychological; Dopamine; Drug Evaluation, Preclinical; Enzyme Inhibitors; Male; Mice; Nicotine; Nicotinic Agonists; Psychotropic Drugs; Random Allocation; Rats, Sprague-Dawley; Reward; Spatial Behavior | 2019 |
Rewarding Effects of Nicotine in Adolescent and Adult Male and Female Rats as Measured Using Intracranial Self-stimulation.
Topics: Age Factors; Animals; Brain; Dose-Response Relationship, Drug; Electrodes, Implanted; Female; Injections, Subcutaneous; Male; Motivation; Nicotine; Rats; Rats, Wistar; Reaction Time; Reward; Self Stimulation | 2020 |
Minimal Circuit Model of Reward Prediction Error Computations and Effects of Nicotinic Modulations.
Topics: Acetylcholine; Anticipation, Psychological; Computer Simulation; Conditioning, Classical; Decision Making; gamma-Aminobutyric Acid; Humans; Models, Neurological; Neural Pathways; Neurons; Nicotine; Receptors, Nicotinic; Reward; Ventral Tegmental Area | 2018 |
Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Cigarette Smoking; Dopamine D2 Receptor Antagonists; Female; Humans; Male; Middle Aged; Nicotine; Reinforcement Schedule; Reward; Schizophrenia; Schizophrenic Psychology; Signal Detection, Psychological; Tobacco Use Disorder; Young Adult | 2019 |
Cannabinoid and nicotine exposure during adolescence induces sex-specific effects on anxiety- and reward-related behaviors during adulthood.
Topics: Animals; Anxiety; Benzoxazines; Conditioning, Operant; Disease Models, Animal; Female; Humans; Locomotion; Male; Mice; Morpholines; Naphthalenes; Nicotine; Reward; Sex Characteristics; Sucrose | 2019 |
Effects of nicotine exposure and anxiety on motivation for reward and gambling-like cues under reward uncertainty.
Topics: Animals; Anxiety; Anxiety Disorders; Conditioning, Classical; Conditioning, Operant; Cues; Female; Gambling; Male; Motivation; Nicotine; Probability; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Uncertainty | 2019 |
Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine.
Topics: Anhedonia; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrodes, Implanted; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Self Administration; Self Stimulation; Time Factors; Tobacco Use Disorder | 2020 |
Sex Differences in the Reward-Enhancing Effects of Nicotine on Ethanol Reinforcement: A Reinforcer Demand Analysis.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Ethanol; Female; Male; Nicotine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reinforcement, Psychology; Reward; Self Administration; Sex Characteristics | 2020 |
The role of endogenous pituitary adenylyl cyclase activating polypeptide (PACAP) in nicotine self-administration, reward and aversion.
Topics: Analysis of Variance; Animals; Aversive Agents; Female; Gene Knockout Techniques; Genotype; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Pituitary Adenylate Cyclase-Activating Polypeptide; Reward; Self Administration; Smoking; Water | 2019 |
The β3 subunit of the nicotinic acetylcholine receptor is required for nicotine withdrawal-induced affective but not physical signs or nicotine reward in mice.
Topics: Animals; Anxiety; Behavior, Animal; Female; Gene Knockout Techniques; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Receptors, Nicotinic; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2019 |
Nicotine or expectancies? Using the balanced-placebo design to test immediate outcomes of vaping.
Topics: Adult; Affect; Appetite; Attention; Electronic Nicotine Delivery Systems; Female; Humans; Male; Middle Aged; Motivation; Nicotine; Personal Satisfaction; Placebo Effect; Research Design; Reward; Vaping; Young Adult | 2019 |
Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption.
Topics: Animals; Dopamine; Dopaminergic Neurons; Female; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Nicotine; Phenotype; Reward; Ventral Tegmental Area | 2019 |
Potential Moderating Effects of Sex/Gender on the Acute Relative Reinforcing and Subjective Effects of Reduced Nicotine Content Cigarettes in Vulnerable Populations.
Topics: Adolescent; Adult; Behavior, Addictive; Female; Humans; Male; Nicotine; Reinforcement, Psychology; Reward; Sex Factors; Smokers; Smoking Cessation; Tobacco Products; Tobacco Smoking; United States; Vulnerable Populations; Young Adult | 2020 |
Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits.
Topics: Agouti-Related Protein; Amphetamine; Animals; Central Nervous System Depressants; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Ethanol; Feeding Behavior; Hypothalamus; Mice; Neural Pathways; Neurons; Nicotine; Nicotinic Agonists; Pro-Opiomelanocortin; Reward; Vagotomy; Vagus Nerve | 2019 |
The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal.
Topics: A549 Cells; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Tolerance; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Nicotine; Nicotinic Agonists; Paclitaxel; Peripheral Nervous System Diseases; Piperazines; Reward | 2019 |
Impact of modulation of the α7 nicotinic acetylcholine receptor on nicotine reward in the mouse conditioned place preference test.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Conditioning, Classical; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Reward | 2019 |
Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Dopaminergic Neurons; Electronic Nicotine Delivery Systems; Farnesol; Female; Flavoring Agents; GABAergic Neurons; Locomotion; Male; Mesencephalon; Mice; Microscopy, Confocal; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Receptors, Nicotinic; Reward; Sex Factors; Up-Regulation; Vaping; Ventral Tegmental Area | 2019 |
Delta-9-THC exposure during zebra finch sensorimotor vocal learning increases cocaine reinforcement in adulthood.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Classical; Dose-Response Relationship, Drug; Dronabinol; Female; Finches; Learning; Male; Nicotine; Reinforcement, Psychology; Reward; Sensorimotor Cortex; Sex Factors; Vocalization, Animal | 2019 |
Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: Alterations to α7 nicotinic acetylcholine receptor expression.
Topics: Aging; Alcohol Drinking; Animals; Dopamine; Dopaminergic Neurons; Ethanol; Female; Humans; Nicotine; Nucleus Accumbens; Rats; Reinforcement, Psychology; Reward; Self Administration; Sexual Maturation; Ventral Tegmental Area | 2019 |
Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats.
Topics: Animals; Anxiety; Brain; Estrous Cycle; Female; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Stimulation; Sex Characteristics; Substance Withdrawal Syndrome | 2019 |
Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem.
Topics: Nicotine; Nicotinic Agonists; Receptors, Nicotinic; Reward | 2019 |
Co-administration of ethanol and nicotine heightens sensitivity to ethanol reward within the nucleus accumbens (NAc) shell and increasing NAc shell BDNF is sufficient to enhance ethanol reward in naïve Wistar rats.
Topics: Alcoholism; Animals; Brain-Derived Neurotrophic Factor; Ethanol; Male; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Reward; Tobacco Use | 2020 |
β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Dopamine; Dopamine Agonists; Flupenthixol; gamma-Aminobutyric Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Motivation; Nicotine; Receptors, Nicotinic; Reward; Ventral Tegmental Area | 2019 |
Pre-Exposure to Nicotine with Nocturnal Abstinence Induces Epigenetic Changes that Potentiate Nicotine Preference.
Topics: Acetylation; Aging; Animals; Behavior, Animal; Brain; Circadian Rhythm; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; Lysine; Nicotine; Phenylbutyrates; Phosphorylation; Protein Subunits; Receptors, Nicotinic; Reward; RNA, Messenger; Task Performance and Analysis; Zebrafish | 2020 |
Microglial activation increases cocaine self-administration following adolescent nicotine exposure.
Topics: Aminopyridines; Animals; Chemokine CX3CL1; Cocaine; Disease Models, Animal; Drug-Seeking Behavior; Electronic Nicotine Delivery Systems; Female; Gene Expression Regulation; Male; Microglia; Minocycline; Nicotine; Phenotype; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reinforcement, Psychology; Reward; Self Administration; Synaptophysin | 2020 |
Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats.
Topics: Animals; Brain; Female; Hypothalamus; Melanocortins; Nicotine; Nucleus Accumbens; Ovariectomy; Rats; Receptor, Melanocortin, Type 4; Reward | 2020 |
Examination of nicotine and saccharin reward in the Goto-Kakizaki diabetic rat model.
Topics: Animals; Conditioning, Psychological; Diabetes Mellitus, Type 2; Disease Models, Animal; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Rats, Wistar; Reward; Saccharin; Self Administration; Species Specificity; Sweetening Agents | 2020 |
Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females.
Topics: Adolescent; Adult; Animals; Cannabinoids; Electronic Nicotine Delivery Systems; Female; Humans; Male; Mice; Mice, Inbred C57BL; Nicotine; Reinforcement, Psychology; Reward; Self Administration | 2020 |
Expression analysis of hippocampal and amygdala CREB-BDNF signaling pathway in nicotine-induced reward under stress in rats.
Topics: Amygdala; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Gene Expression; Hippocampus; Injections, Subcutaneous; Male; Nicotine; Rats; Rats, Wistar; Reward; Signal Transduction; Stress, Psychological | 2020 |
Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice.
Topics: Animals; Anti-Anxiety Agents; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Agonists; Conditioning, Classical; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Monoacylglycerol Lipases; Nicotine; Piperidines; Receptor, Cannabinoid, CB1; Reward; Tobacco Use Disorder | 2020 |
Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzoates; Disease Models, Animal; Nicotine; Nicotinic Antagonists; Pyrrolidines; Receptors, Nicotinic; Reward; Swimming; Zebrafish | 2020 |
Pre-conception exposure to THC fails to impact nicotine reward in adult offspring.
Topics: Animals; Animals, Newborn; Dronabinol; Female; Fertilization; Locomotion; Male; Nicotine; Nicotinic Agonists; Pregnancy; Psychotropic Drugs; Rats; Reinforcement Schedule; Reward; Self Administration; Sex Factors | 2020 |
Nicotine Facilitation of Conditioned Place Preference to Food Reward in Humans.
Topics: Conditioning, Psychological; Food; Humans; Nicotine; Reward; Students | 2020 |
Flavors Enhance Nicotine Vapor Self-administration in Male Mice.
Topics: Administration, Inhalation; Animals; Flavoring Agents; Male; Mice; Mice, Inbred C57BL; Nicotine; Reinforcement, Psychology; Reward; Self Administration | 2021 |
Temporal discounting and smoking cessation: choice consistency predicts nicotine abstinence in treatment-seeking smokers.
Topics: Adult; Bayes Theorem; Brain; Choice Behavior; Chronic Disease; Delay Discounting; Female; Humans; Magnetic Resonance Imaging; Male; Nicotine; Reward; Smokers; Smoking; Smoking Cessation; Surveys and Questionnaires; Tobacco Use Disorder | 2021 |
Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine Withdrawal.
Topics: Animals; Conditioning, Classical; Female; Gene Expression Regulation; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Receptors, Dopamine; Receptors, Oxytocin; Receptors, Purinergic P1; Reward; RNA, Messenger; Substance Withdrawal Syndrome; Swimming; Time Factors; Zebrafish | 2021 |
Tobacco smoke exposure enhances reward sensitivity in male and female rats.
Topics: Animals; Brain; Cotinine; Female; Male; Nicotiana; Nicotine; Rats; Rats, Wistar; Reaction Time; Reward; Self Stimulation; Tobacco Smoke Pollution; Tobacco Use Disorder | 2021 |
Methionine Supplementation Abolishes Nicotine-Induced Place Preference in Zebrafish: a Behavioral and Molecular Analysis.
Topics: 5-Methylcytosine; Animals; Azacitidine; Behavior, Animal; Brain; Choice Behavior; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Methionine; Nicotine; Phosphorylation; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Reward; RNA, Messenger; Zebrafish; Zebrafish Proteins | 2021 |
Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Cues; Drug-Seeking Behavior; Extinction, Psychological; Food; Male; Nicotine; Rats; Reward; Social Isolation; Sucrose | 2021 |
Isolation drives reward-seeking in rats.
Topics: Animals; Housing; Nicotine; Rats; Reward; Social Isolation; Sucrose | 2021 |
Genetic and Depressive Traits Moderate the Reward-Enhancing Effects of Acute Nicotine in Young Light Smokers.
Topics: Humans; Nicotine; Reward; Smokers; Smoking; Tobacco Use Disorder | 2021 |
Rewarding Effects of Nicotine Self-administration Increase Over Time in Male and Female Rats.
Topics: Animals; Electronic Nicotine Delivery Systems; Female; Male; Nicotine; Rats; Rats, Wistar; Reward; Self Stimulation | 2021 |
Reward-enhancing effects of d-amphetamine and its interactions with nicotine were greater in female rats and persisted across schedules of reinforcement.
Topics: Amphetamine-Related Disorders; Animals; Behavior, Animal; Central Nervous System Stimulants; Comorbidity; Dextroamphetamine; Drug Synergism; Female; Humans; Male; Nicotine; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Sex Factors; Tobacco Use Disorder | 2021 |
The effects of quercetin on nicotine-induced reward effects in mice.
Topics: Animals; Conditioning, Psychological; Male; Mice; Nicotine; Quercetin; Reward; Tobacco Use Disorder | 2021 |
Exposure to Nicotine Vapor Produced by an Electronic Nicotine Delivery System Causes Short-Term Increases in Impulsive Choice in Adult Male Rats.
Topics: Adolescent; Animals; Choice Behavior; Electronic Nicotine Delivery Systems; Humans; Impulsive Behavior; Male; Nicotine; Rats; Reward; Vaping | 2022 |
Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish.
Topics: Animals; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Nicotine; Reward; Zebrafish | 2022 |
An ongoing saga of nicotine complexity and dopamine heterogeneity: Nicotine activation and inhibition mediating reward and anxiety.
Topics: Anxiety; Dopamine; Dopaminergic Neurons; Nicotine; Reward; Ventral Tegmental Area | 2021 |
Novel Putative Positive Modulators of α4β2 nAChRs Potentiate Nicotine Reward-Related Behavior.
Topics: Animals; Behavior, Animal; Calcium; Female; Male; Mice, Inbred C57BL; Nicotine; Receptors, Nicotinic; Reward; Time Factors | 2021 |
Role of cytokine and neurotrophic factors in nicotine addiction in the conditioned place preference paradigm.
Topics: Animals; Brain-Derived Neurotrophic Factor; Conditioning, Psychological; Corpus Striatum; Disease Models, Animal; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Humans; Injections, Intraperitoneal; Interleukin-10; Interleukin-1beta; Male; Mice; Neuroinflammatory Diseases; Nicotine; Prefrontal Cortex; Reward; Tobacco Use Disorder | 2021 |
Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.
Topics: Animals; Conditioning, Operant; Dextroamphetamine; Drug Combinations; Female; Humans; Male; Nicotine; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Sex Characteristics; Substance-Related Disorders | 2022 |
Nicotine modulation of the lateral habenula/ventral tegmental area circuit dynamics: An electrophysiological study in rats.
Topics: Animals; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Electroencephalography; Habenula; Male; Neural Pathways; Nicotine; Rats, Sprague-Dawley; Reward; Ventral Tegmental Area | 2022 |
Neural bases of risky decisions involving nicotine vapor versus monetary reward.
Topics: Female; Gambling; Humans; Magnetic Resonance Imaging; Male; Nicotine; Reward; Smokers | 2021 |
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice.
Topics: Animals; Behavior, Animal; Dopamine; Dopaminergic Neurons; Exploratory Behavior; Male; Mesencephalon; Mice; Models, Animal; Nicotine; Optogenetics; Prejudice; Reward; Self Administration; Stereotaxic Techniques | 2021 |
Morphine Exposure Reduces Nicotine-Induced Upregulation of Nicotinic Receptors and Decreases Volitional Nicotine Intake in a Mouse Model.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Morphine; Nicotine; Receptors, Nicotinic; Reward; Up-Regulation; Ventral Tegmental Area | 2022 |
Attenuation of nicotine-induced rewarding and antidepressant-like effects in male and female mice lacking regulator of G-protein signaling 2.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Conditioning, Psychological; Depression; Elevated Plus Maze Test; Female; Locomotion; Male; Mice; Nicotine; Reward; RGS Proteins | 2022 |
Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice.
Topics: Animals; Male; Mice; Nicotine; Receptors, Nicotinic; Reward; Weight Loss | 2022 |
Evaluation of drug seeking behavior on nicotine conditioned place preference in zebrafish.
Topics: Animals; Conditioning, Classical; Drug-Seeking Behavior; Nicotine; Reward; Zebrafish | 2022 |
A common SNP in Chrna5 enhances morphine reward in female mice.
Topics: Animals; Female; Male; Mice; Morphine; Nerve Tissue Proteins; Nicotine; Polymorphism, Single Nucleotide; Receptors, Nicotinic; Reward | 2022 |
Misalignment of Reward Response With Healthful Behavior: An Underappreciated Driver of Population Health Deficits and Health Disparities?
Topics: Health Behavior; Humans; Hyperphagia; Nicotine; Population Health; Reward; Social Class | 2022 |
Pharmacological investigations of effort-based decision-making in humans: Naltrexone and nicotine.
Topics: Adult; Cholinergic Agents; Decision Making; Dopamine; Humans; Motivation; Naltrexone; Nicotine; Pilot Projects; Reward | 2022 |
Male and Female Sprague Dawley Rats Exhibit Equivalent Natural Reward, Nicotine Self-Administration, Extinction, and Reinstatement During Adolescent-Initiated Behaviors.
Topics: Animals; Conditioning, Operant; Cues; Extinction, Psychological; Female; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Self Administration | 2023 |
Effects of short-term nicotine deprivation on delay discounting among young, experienced, exclusive ENDS users: An initial study.
Topics: Delay Discounting; Humans; Impulsive Behavior; Nicotine; Reward; Vaping; Young Adult | 2023 |
Metacognitive deficits are associated with lower sensitivity to preference reversals in nicotine dependence.
Topics: Humans; Metacognition; Motivation; Nicotine; Reward; Tobacco Use Disorder | 2022 |
Determinants of food reward and some parallels with vehicles for self-administration of nicotine, caffeine and alcohol.
Topics: Caffeine; Ethanol; Humans; Nicotine; Reward | 2023 |
Effects of Dextromethorphan on Nicotine-Induced Reward, Behavioral Sensitization, Withdrawal Signs, and Drug Seeking-Related Behavior in Rats.
Topics: Animals; Dextromethorphan; Dopamine; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2023 |
ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Neuronal Plasticity; Nicotine; Nucleus Accumbens; Receptors, Nicotinic; Reward; Signal Transduction; Ventral Tegmental Area | 2023 |
Nicotinic and muscarinic acetylcholine receptor antagonism dose-dependently decreases sign- but not goal-tracking behavior in male rats.
Topics: Animals; Cues; Male; Mecamylamine; Motivation; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Scopolamine Derivatives | 2023 |
Impact of the gut microbiome on nicotine's motivational effects and glial cells in the ventral tegmental area in male mice.
Topics: Animals; Dopamine; Gastrointestinal Microbiome; Male; Mice; Neuroglia; Nicotine; Reward; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2023 |
Lifetime caffeine and adolescent nicotine exposure in mice: effects on anxiety-like behavior and reward.
Topics: Adolescent; Animals; Anxiety; Behavior, Animal; Caffeine; Dopamine; Humans; Mice; Nicotine; Reward | 2023 |
Interaction of nicotine and social reward in group-reared male adolescent rats.
Topics: Animals; Male; Motivation; Nicotine; Rats; Rats, Wistar; Reward; Social Behavior | 2023 |
L-theanine attenuates nicotine reward and withdrawal signs in mice.
Topics: Animals; Humans; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2023 |
Strawberry Additive Increases Nicotine Vapor Sampling and Systemic Exposure But Does Not Enhance Pavlovian-Based Nicotine Reward in Mice.
Topics: Animals; Electronic Nicotine Delivery Systems; Female; Fragaria; Male; Mice; Nicotine; Reward; Vaping | 2023 |
Poor inhibitory control predicts sex-specific vulnerability to nicotine rewarding properties in mice.
Topics: Animals; Attention; Conditioning, Classical; Female; Male; Mice; Nicotine; Reward; Tobacco Use Disorder | 2023 |