nicotine has been researched along with procainamide in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 7 (21.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ganapathy, V; Leibach, FH; Prasad, PD; Wu, X | 1 |
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Chen, J; Conway, SJ; Ganapathy, V; Huang, W; Leibach, FH; Prasad, PD; Rajan, DP; Seth, P; Wu, X | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y | 1 |
| Bednarczyk, D; Ekins, S; Wikel, JH; Wright, SH | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Iwamoto, ET | 1 |
| Giurgea, C; Mouravieff-Lesuisse, F | 2 |
| Aihara, H; Otsuki, K; Ozawa, M | 1 |
| Bianchi, C; Sanna, GP; Turba, C | 1 |
| Chancy, CD; Ganapathy, V; Huang, W; Kekuda, R; Rajan, PD; Smith, SB | 1 |
| Higo, A; Katsura, M; Mohri, Y; Ohkuma, S; Shuto, K; Takesue, M; Tarumi, C; Tsujimura, A | 1 |
| PATON, WD; THOMPSON, JW | 1 |
| Axelsson, BO; Axén, J; Malmström, D; Petersson, P; Sjöberg, PJ | 1 |
32 other study(ies) available for nicotine and procainamide
| Article | Year |
|---|---|
cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family.
Topics: Amines; Amino Acid Sequence; Base Sequence; Biological Transport; Carrier Proteins; Chromosomes, Human, Pair 5; Cloning, Molecular; DNA, Complementary; Guanidines; Human Genome Project; Humans; Ions; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Pyridines; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Solute Carrier Family 22 Member 5; Symporters; Tetraethylammonium | 1998 |
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter.
Topics: Acetylcarnitine; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Humans; In Situ Hybridization; Kidney; Membrane Proteins; Mice; Myocardium; Organ Specificity; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection | 2002 |
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
Topics: Computational Biology; HeLa Cells; Humans; Models, Molecular; Organic Cation Transporter 1; Pyridinium Compounds; Quinolinium Compounds; Structure-Activity Relationship; Transfection | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Characterization of the antinociception induced by nicotine in the pedunculopontine tegmental nucleus and the nucleus raphe magnus.
Topics: Analgesia; Animals; Dioxolanes; Glutamates; Glutamic Acid; Hemicholinium 3; Male; Mecamylamine; Medulla Oblongata; Naloxone; Nicotine; Procainamide; Raphe Nuclei; Rats; Rats, Inbred Strains; Reflex | 1991 |
Pharmacological studies on an elementary model of learning--the fixation of an experience at spinal level. I. Pharmacological reactivity of the spinal cord fixation time.
Topics: Animals; Antithyroid Agents; Azaguanine; Cerebellum; Cyanides; Hindlimb; Learning; Memory; Models, Psychological; Nicotine; Pemoline; Phenytoin; Posture; Procainamide; Psychophysiology; Pyrrolidinones; Rats; RNA; Spinal Cord; Strychnine; Time Factors; Transaminases | 1971 |
[Effect of lidocaine on ganglionic transmission].
Topics: Acetylcholine; Animals; Blood Pressure; Cats; Electric Stimulation; Epinephrine; Female; Ganglia, Autonomic; Humans; Injections, Intra-Articular; Injections, Intravenous; Lidocaine; Male; Nicotine; Norepinephrine; Potassium Chloride; Procainamide; Procaine; Scopolamine; Synaptic Transmission; Tetraethylammonium Compounds | 1967 |
Acute toxicity and general pharmacologic properties of 1,5-dimorpholino-3-(1-naphthyl)-pentane: DA 1686.
Topics: Acetylcholine; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Arteries; Autonomic Nervous System; Blood Pressure; Cardiovascular System; Diuresis; Electrocardiography; Guinea Pigs; Heart; Heart Rate; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Male; Mice; Natriuresis; Nicotine; Procainamide; Quinidine; Rabbits; Rats; Respiration; Sensory Receptor Cells | 1968 |
Influence of electro-convulsive shock on the fixation of an experience at spinal level.
Topics: Animals; Electroshock; Learning; Memory; Nicotine; Phenytoin; Posture; Procainamide; Propylamines; Rats; Time Factors | 1970 |
Expression of the extraneuronal monoamine transporter in RPE and neural retina.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amphetamine; Animals; Biogenic Monoamines; Blotting, Northern; Carrier Proteins; Cells, Cultured; Eye; Female; Gene Expression; Humans; Hydrogen-Ion Concentration; In Situ Hybridization; Kinetics; Methamphetamine; Mice; Mice, Inbred ICR; Nicotine; Organic Cation Transport Proteins; Pigment Epithelium of Eye; Procainamide; Retina; RNA, Messenger; Steroids; Tetraethylammonium; Time Factors | 2000 |
Mechanism for increase in expression of cerebral diazepam binding inhibitor mRNA by nicotine: involvement of L-type voltage-dependent calcium channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anesthetics, Local; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Radioisotopes; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Diazepam Binding Inhibitor; Dibucaine; Enzyme Inhibitors; Gene Expression; Hexamethonium; Lidocaine; Membrane Potentials; Mice; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; omega-Agatoxin IVA; omega-Conotoxin GVIA; Platelet Aggregation Inhibitors; Procainamide; RNA, Messenger; Sulfonamides; Tetrodotoxin; Tritium | 2000 |
THE GANGLION BLOCKING ACTION OF PROCAINAMIDE.
Topics: Acetylcholine; Animals; Blood Pressure; Cats; Electrophysiology; Ganglia; Ganglionic Blockers; Guinea Pigs; Heart; Hexamethonium; Hexamethonium Compounds; Histamine; Ileum; Nicotine; Nictitating Membrane; Norepinephrine; Pharmacology; Procainamide; Procaine; Rabbits; Research | 1964 |
Efforts to improve detection sensitivity for capillary electrophoresis coupled to atmospheric pressure photoionization mass spectrometry.
Topics: Albuterol; Electrophoresis, Capillary; Mass Spectrometry; Nicotine; Procainamide; Sensitivity and Specificity | 2010 |