nicotine has been researched along with prazosin in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (9.84) | 18.7374 |
| 1990's | 20 (32.79) | 18.2507 |
| 2000's | 22 (36.07) | 29.6817 |
| 2010's | 12 (19.67) | 24.3611 |
| 2020's | 1 (1.64) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Starke, K; von Kügelgen, I | 1 |
| Bulloch, JM; Bültmann, R; Starke, K; von Kügelgen, I | 1 |
| Woodman, OL | 1 |
| Bültmann, R; Starke, K; von Kügelgen, I | 1 |
| Matta, SG; Sharp, BM; Singh, J | 1 |
| Hayashi, S; Kitamura, Y; Nomura, Y | 1 |
| Andersson, KE; Forman, A; Funch-Jensen, P; Raundahl, U; Tøttrup, A | 1 |
| Kitazawa, T; Kondo, H; Temma, K | 1 |
| Muramatsu, I; Oshita, M; Yamanaka, K | 1 |
| Grayson, J; Oyebola, DD | 1 |
| Vatner, SF | 1 |
| Kigoshi, S; Muramatsu, I; Oshita, M | 1 |
| Okamura, T; Toda, N; Yoshida, K | 1 |
| Okamura, T; Toda, N | 1 |
| Fasanmade, AA; Oyebola, DD | 1 |
| Alada, AR; Oyebola, DD | 1 |
| Ferger, B; Kuschinsky, K | 1 |
| Appalsamy, M; Mosqueda-Garcia, R; Robertson, D; Tseng, CJ | 1 |
| An, J; Okamura, T; Toda, N; Uchiyama, M | 1 |
| Kimura, T; Okamura, T; Toda, N | 1 |
| Fujimoto, H; Hayashida, H; Okamura, T; Toda, N; Tomoyoshi, T; Yoshida, K | 1 |
| Ayajiki, K; Okamura, T; Toda, N; Uchiyama, M | 1 |
| Karien, RG; Maisel, RH | 1 |
| Ayajiki, K; Kagami, K; Okamura, T; Toda, N; Uchiyama, M | 1 |
| Ayajiki, K; Hayashida, H; Okamura, T; Toda, N | 1 |
| Lee, TJ; Sarwinski, S; Zhang, W | 1 |
| Babaie, A; Etminani, A; Gharib, B; Homayoun, H; Zarrindast, MR | 1 |
| Ammar, ES; Ayajiki, K; Ghoneim, HA; Okamura, T; Toda, N | 1 |
| Fasanmade, AA; Ogwumike, OO | 1 |
| Brain, KL; Cunnane, TC; Dass, N; Jackson, VM; Trout, SJ | 1 |
| Ichimura, K; Maeda, Y; Okita, W | 1 |
| Hahn, B; Stolerman, IP | 1 |
| Cunnane, TC; Cuprian, AM; Jackson, MV; Solanki, P | 1 |
| Belluzzi, JD; Leslie, FM; Lotfipour, S; Villégier, AS | 1 |
| Doucet, EL; Godeheu, G; Hernández Vallejo, SJ; Houades, V; Lanteri, C; Salomon, L; Tassin, JP; Torrens, Y | 1 |
| Forget, B; Hamon, M; Thiébot, MH | 1 |
| De Lima, TC; Lapa, AJ; Lima-Landman, MT; Munhoz, E; Souccar, C | 1 |
| Caggiula, AR; Donny, EC; Levin, ME; Mays, KL; Palmatier, MI; Sved, AF | 1 |
| Alada, AR; Idolor, GO; Isehunwa, GO; Owoeye, O; Oyebola, DD; Taiwo, EO | 2 |
| Forget, B; Goldberg, SR; Le Foll, B; Mascia, P; Pushparaj, A; Wertheim, C | 1 |
| Alexander, JC; Bishnoi, M; Bruijnzeel, AW; Ford, J; Keijzers, KF; Pasek, TM; van Tuijl, IA; Yamada, H; Yavarovich, KR | 1 |
| Alexander, JC; Bishnoi, M; Bruijnzeel, AW; Ford, J; Ji, Y; Rogers, JA; Scheick, S | 1 |
| Chan, TMV; Clarke, PBS; Rahman, S; Ren, S; Satanove, DJ | 1 |
1 trial(s) available for nicotine and prazosin
| Article | Year |
|---|---|
Increased nasal patency caused by smoking and contraction of isolated human nasal mucosa.
Topics: Adrenergic alpha-Antagonists; Adult; Central Nervous System Stimulants; Chewing Gum; Culture Techniques; Humans; Male; Nasal Cavity; Nasal Mucosa; Nicotine; Norepinephrine; Polymethacrylic Acids; Polyvinyls; Prazosin; Rhinometry, Acoustic; Smoking; Sympathomimetics; Tobacco Use Cessation Devices | 2004 |
60 other study(ies) available for nicotine and prazosin
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Release of noradrenaline and ATP by electrical stimulation and nicotine in guinea-pig vas deferens.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Guanethidine; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Prazosin; Synaptic Transmission; Tetrodotoxin; Vas Deferens | 1991 |
Noradrenaline-ATP corelease and cotransmission following activation of nicotine receptors at postganglionic sympathetic axons.
Topics: Adenosine Triphosphate; Animals; Axons; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Nicotine; Prazosin; Rabbits; Receptors, Nicotinic; Synaptic Transmission; Vas Deferens; Vasoconstriction | 1991 |
Coronary vascular responses to nicotine in the anaesthetized dog.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Atropine; Coronary Vessels; Dogs; Female; Injections, Intra-Arterial; Injections, Intravenous; Male; Muscarinic Antagonists; Nicotine; Parasympathetic Nervous System; Prazosin; Propranolol; Sympathetic Nervous System; Vagotomy; Vascular Resistance | 1991 |
Adrenergic and purinergic cotransmission in nicotine-evoked vasoconstriction in rabbit ileocolic arteries.
Topics: Adenosine Triphosphate; Animals; Arteries; Colon; Dose-Response Relationship, Drug; Female; Male; Nicotine; Norepinephrine; Prazosin; Rabbits; Receptors, Nicotinic; Suramin; Vasoconstriction | 1991 |
Catecholamines mediate nicotine-induced adrenocorticotropin secretion via alpha-adrenergic receptors.
Topics: Adrenocorticotropic Hormone; Animals; Benzylamines; Brain; Brain Stem; Catecholamines; Hydroxydopamines; Isoquinolines; Male; Nicotine; Norepinephrine; Oxidopamine; Prazosin; Rats; Receptors, Adrenergic, alpha; Tetrahydroisoquinolines; Yohimbine | 1990 |
Effects of WEB 1881 FU, a novel nootropic, on cholinergic and adrenergic receptors in the rat brain: action on M1-muscarinic receptors.
Topics: Animals; Brain Chemistry; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Iodocyanopindolol; Kinetics; Male; Nicotine; Parasympatholytics; Pindolol; Pirenzepine; Prazosin; Pyrrolidinones; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Muscarinic; Thionucleotides; Yohimbine | 1990 |
Effects of transmural field stimulation in isolated muscle strips from human esophagus.
Topics: Atropine; Carbachol; Electric Stimulation; Esophagus; Humans; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle, Smooth; Nicotine; Phentolamine; Prazosin; Propranolol; Stomach; Tetrodotoxin; Yohimbine | 1990 |
Presynaptic alpha-adrenoceptor mediated inhibition of the neurogenic cholinergic contraction in the isolated intestinal bulb of the carp (Cyprinus carpio).
Topics: Animals; Atropine; Carps; Catecholamines; Clonidine; Cyprinidae; Electric Stimulation; Epinephrine; Female; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Parasympathetic Nervous System; Phentolamine; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha; Tetrodotoxin; Yohimbine | 1986 |
Alteration of alpha and muscarinic receptors in rat brain and heart following chronic nicotine treatment.
Topics: Animals; Brain; Brain Stem; Cerebral Cortex; Clonidine; Hypothalamus; Male; Myocardium; Nicotine; Prazosin; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Thalamus; Time Factors | 1985 |
Effect of nicotine on blood flow, oxygen consumption and glucose uptake in the canine small intestine.
Topics: Animals; Blood Glucose; Blood Pressure; Dogs; Glucose; Injections, Intravenous; Intestine, Small; Nicotine; Oxygen Consumption; Prazosin; Propranolol; Regional Blood Flow; Vascular Resistance | 1985 |
Alpha-adrenergic tone in the coronary circulation of the conscious dog.
Topics: Animals; Blood Pressure; Carotid Arteries; Coronary Circulation; Dogs; Infusions, Intra-Arterial; Nicotine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha; Regional Blood Flow; Vascular Resistance | 1984 |
Nonadrenergic nature of prazosin-resistant, sympathetic contraction in the dog mesenteric artery.
Topics: Animals; Cocaine; Dogs; Electric Stimulation; Female; Guanethidine; Hydroxydopamines; In Vitro Techniques; Male; Mesenteric Arteries; Nicotine; Norepinephrine; Oxidopamine; Prazosin; Quinazolines; Receptors, Adrenergic; Reserpine; Sympathetic Nervous System; Tetrodotoxin; Tyramine; Vasoconstriction | 1984 |
Involvement of nitroxidergic and noradrenergic nerves in the relaxation of dog and monkey temporal veins.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amino Acid Oxidoreductases; Animals; Arginine; Atropine; Dinoprost; Dogs; Electric Stimulation; Female; Hexamethonium; Indomethacin; Macaca; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH Dehydrogenase; Nerve Fibers; Nicotine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Prazosin; Tetrodotoxin; Timolol; Veins | 1995 |
Mechanism underlying nicotine-induced relaxation in dog saphenous arteries.
Topics: Animals; Arginine; Calcitonin Gene-Related Peptide; Dogs; Drug Interactions; Female; Hexamethonium; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nitroarginine; Prazosin; Vasoactive Intestinal Peptide | 1994 |
Effects of adrenoceptor blockers on the cardiorespiratory response to nicotine in rats.
Topics: Animals; Disease Models, Animal; Drug Interactions; Hemodynamics; Male; Nicotine; Prazosin; Premedication; Propranolol; Rats; Rats, Wistar; Respiration | 1993 |
Effects of adrenergic receptor blockers on adrenaline and nicotine-induced hyperglycaemia in the rat.
Topics: Animals; Blood Glucose; Disease Models, Animal; Dogs; Epinephrine; Hyperglycemia; Male; Nicotine; Practolol; Prazosin; Propranolol; Rats; Rats, Wistar; Time Factors | 1993 |
Activation of dopamine D1 receptors or alpha 1 adrenoceptors is not involved in the EEG effect of nicotine in rats.
Topics: Animals; Electrodes; Electroencephalography; Injections, Intraperitoneal; Male; Mecamylamine; Motor Activity; Nicotine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Receptors, Nicotinic | 1994 |
Effects of nicotine on brain stem mechanisms of cardiovascular control.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Heart Rate; Hexamethonium; Hexamethonium Compounds; Labetalol; Male; Nicotine; Physostigmine; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley | 1993 |
Nitric oxide-mediated neurogenic relaxation in monkey mesenteric veins.
Topics: Animals; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Mesenteric Veins; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide; Norepinephrine; Prazosin; Vasodilation | 1995 |
Nitroxidergic nerve stimulation relaxes human uterine vein.
Topics: Adult; Arginine; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Leiomyoma; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nicotine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Prazosin; Sympatholytics; Uterine Neoplasms; Uterus; Vasodilation; Veins | 1995 |
Comparison of neurogenic contraction and relaxation in canine corpus cavernosum and penile artery and vein.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Arteries; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Hexamethonium; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurons, Efferent; Nicotine; Nicotinic Agonists; Penile Erection; Penis; Prazosin; Veins | 1996 |
Nitric oxide-mediated neurogenic vasodilatation in isolated monkey lingual arteries.
Topics: Adenosine Triphosphate; Animals; Arteries; Dinoprost; Electric Stimulation; Female; In Vitro Techniques; Macaca; Male; Muscle, Smooth, Vascular; Nerve Fibers; Neurons; Nicotine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Prazosin; Stereoisomerism; Tongue; Vasodilation | 1997 |
Terazosin blockade of nicotine-induced skin flap necrosis in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Graft Survival; Male; Necrosis; Nicotine; Prazosin; Random Allocation; Rats; Rats, Sprague-Dawley; Surgical Flaps | 1997 |
Mechanisms underlying constrictor and dilator responses to perivascular nerve stimulation in canine lingual arteries.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Arteries; Dinoprost; Dogs; Electric Stimulation; Female; Ganglionic Stimulants; In Vitro Techniques; Male; Nicotine; Prazosin; Tongue; Vasoconstriction; Vasodilation | 1998 |
Influence of denervation on neurogenic inhibitory response of corpus cavernosum and nitric oxide synthase histochemistry.
Topics: Adenosine Triphosphate; Animals; Denervation; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Male; NADPH Dehydrogenase; Nerve Fibers; Neural Inhibition; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Penis; Prazosin; Stimulation, Chemical; Sympatholytics; Tetrodotoxin | 1999 |
Presynaptic beta(2)-adrenoceptors mediate nicotine-induced NOergic neurogenic dilation in porcine basilar arteries.
Topics: Adrenergic beta-Antagonists; Animals; Basilar Artery; Butoxamine; Endothelium, Vascular; Female; In Vitro Techniques; Male; Models, Cardiovascular; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide; Prazosin; Propanolamines; Receptors, Adrenergic, beta-2; Swine; Vasodilation; Yohimbine | 2000 |
Involvement of adrenergic and cholinergic systems in nicotine-induced anxiogenesis in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anxiety; Atropine; Clonidine; Hexamethonium; Male; Mecamylamine; Mice; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha-1; Yohimbine | 2000 |
Mechanisms underlying contraction and relaxation induced by nerve stimulation in monkey uterine arteries.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Arteries; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Macaca; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Prazosin; Uterus | 2000 |
Effects of adrenoceptor blockers on the glycemic response to nicotine in thyroidectomised rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hyperglycemia; Male; Nicotine; Prazosin; Propranolol; Rats; Rats, Wistar; Thyroid Hormones; Thyroidectomy; Time Factors | 2000 |
Nicotine induces calcium spikes in single nerve terminal varicosities: a role for intracellular calcium stores.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Calcium; Calcium Channels; Calcium Signaling; Electric Stimulation; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Hexamethonium; Intracellular Fluid; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Nicotine; Nicotinic Antagonists; Organic Chemicals; Prazosin; Presynaptic Terminals; Receptors, Nicotinic; Ryanodine; Sympathetic Fibers, Postganglionic; Tetrodotoxin; Vas Deferens | 2001 |
Modulation of nicotine-induced attentional enhancement in rats by adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Attention; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Propranolol; Psychomotor Performance; Rats; Reaction Time | 2005 |
Cholinergic innervation of the mouse isolated vas deferens.
Topics: Acetylcholine; Animals; Atropine; Bretylium Compounds; Cyclopentolate; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Neostigmine; Nicotine; Parasympathetic Nervous System; Prazosin; Vas Deferens; Yohimbine | 2005 |
Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Dopamine; Male; Microdialysis; Monoamine Oxidase Inhibitors; Nicotine; Nicotinic Agonists; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Reward; Self Administration; Tranylcypromine | 2007 |
Inhibition of monoamine oxidases desensitizes 5-HT1A autoreceptors and allows nicotine to induce a neurochemical and behavioral sensitization.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Behavior, Animal; Brain Chemistry; Drug Combinations; Fluorobenzenes; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nicotine; Nicotinic Agonists; Phenols; Piperazines; Prazosin; Pyridines; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists; Serotonin Receptor Agonists; Tranylcypromine | 2009 |
Involvement of alpha1-adrenoceptors in conditioned place preference supported by nicotine in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Cues; Male; Motivation; Nicotine; Nicotinic Agonists; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 2009 |
Allosteric interaction of the anticholinergic drug [N-(4-phenyl)-phenacyl-l-hyoscyamine] (Phenthonium) with nicotinic receptors of post-ganglionic sympathetic neurons of the rat vas deferens.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Atropine; Atropine Derivatives; Cholinergic Antagonists; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Sympathetic; In Vitro Techniques; Male; Motor Activity; Muscle Contraction; Neurons; Nicotine; Norepinephrine; Prazosin; Rats; Rats, Wistar; Receptors, Nicotinic; Suramin; Synaptic Transmission; Vas Deferens | 2009 |
Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Bupropion; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mecamylamine; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Time Factors | 2009 |
Effect of nicotine on glucose uptake in the rabbit small intestine.
Topics: Analysis of Variance; Animals; Blood Glucose; Glucose; Injections, Intravenous; Intestine, Small; Male; Nicotine; Prazosin; Propranolol; Rabbits; Regional Blood Flow; Vascular Resistance | 2009 |
Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Conditioning, Operant; Cues; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Food Preferences; Microdialysis; Nicotine; Nicotinic Agonists; Prazosin; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Tobacco Use Disorder | 2010 |
Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Propranolol; Rats; Rats, Wistar; Reaction Time; Reinforcement, Psychology; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2010 |
Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Amygdala; Animals; Benzenesulfonates; Clonidine; Electrodes, Implanted; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Quinolines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2012 |
Effect of adrenaline on glucose uptake in the rabbit small intestine.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Epinephrine; Glucose; Hindlimb; Injections, Intravenous; Intestine, Small; Male; Nicotine; Prazosin; Propranolol; Rabbits | 2011 |
Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Benzazepines; Conditioning, Operant; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Prazosin; Propranolol; Rats; Receptors, Nicotinic; Reinforcement, Psychology | 2021 |