Page last updated: 2024-08-26

nicotine and ondansetron

nicotine has been researched along with ondansetron in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (35.71)18.2507
2000's9 (32.14)29.6817
2010's8 (28.57)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gordon, JC; Gurley, D; Lanthorn, T; Loch, J; Mack, RA; Macor, JE; Mullen, G; Tran, O; Wright, N1
Keserü, GM1
Nagashima, R; Nishikawa, T; Tobita, M1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Jia, L; Sun, H1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Ito, T; Omoya, H; Yoshida, N1
Costall, B; Jones, BJ; Kelly, ME; Naylor, RJ; Onaivi, ES; Tyers, MB1
Everitt, BJ; Muir, JL; Robbins, TW1
Allison, K; Arnold, B; Greenshaw, AJ; Ivanová, S; Paetsch, PR; Paslawski, T1
Herberg, LJ; Montgomery, AM; Rose, IC1
Apfelbaum, JL; Lichtor, JL; Zacny, JP; Zaragoza, JG1
Bhattacharya, SK; Chakrabarti, A; Glover, V; Sandler, M1
Hajek, P; West, R1
Ise, Y; Misawa, M; Mori, T; Suzuki, T1
Greenshaw, AJ; Ivanová, S1
Cheng, Q; Dergacheva, O; Gorini, C; Jameson, HS; Kamendi, HW; McIntosh, JM; Mendelowitz, D; Wang, X1
Grady, SR; Marks, MJ; O'Neill, HC; Ortiz, NC1
Iha, HA; Kunisawa, N; Matsubara, N; Nomura, Y; Ohno, Y; Onishi, M; Shimizu, S1
Buzoianu, AD; Feng, L; Lafuente, JV; Li, C; Muresanu, DF; Nozari, A; Sharma, A; Sharma, HS; Sharma, S; Sjöqvisst, PO; Tian, ZR; Wiklund, L; Zhang, Z1

Reviews

1 review(s) available for nicotine and ondansetron

ArticleYear
Nicotine neurotoxicity exacerbation following engineered Ag and Cu (50-60 nm) nanoparticles intoxication. Neuroprotection with nanowired delivery of antioxidant compound H-290/51 together with serotonin 5-HT3 receptor antagonist ondansetron.
    International review of neurobiology, 2023, Volume: 172

    Topics: Animals; Antioxidants; Brain; Brain Edema; Humans; Nanoparticles; Neuroprotection; Neuroprotective Agents; Nicotine; Ondansetron; Serotonin 5-HT3 Receptor Antagonists

2023

Trials

2 trial(s) available for nicotine and ondansetron

ArticleYear
Effects of 5-hydroxytryptamine3 antagonist, ondansetron, on cigarette smoking, smoke exposure, and mood in humans.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:2

    Topics: Adult; Affect; Double-Blind Method; Female; Humans; Male; Nicotine; Ondansetron; Prospective Studies; Smoking; Smoking Cessation; Tobacco Smoke Pollution

1993
Randomised controlled trial of ondansetron in smoking cessation.
    Psychopharmacology, 1996, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotine; Ondansetron; Serotonin Antagonists; Smoking Cessation; Substance Withdrawal Syndrome

1996

Other Studies

25 other study(ies) available for nicotine and ondansetron

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.
    Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Membrane; Hippocampus; Indoles; Inhibitory Concentration 50; Intestine, Small; Ligands; Membrane Potentials; Mice; Nicotinic Agonists; Oocytes; Protein Binding; Rats; Receptors, Nicotinic; Serotonin Antagonists; Structure-Activity Relationship; Tropisetron; Xenopus

2001
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
DAT-582, a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent in the ferret and dog.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3

    Topics: Animals; Antiemetics; Azepines; Cisplatin; Copper; Copper Sulfate; Dogs; Female; Ferrets; Gastric Emptying; Imidazoles; Indazoles; Male; Nicotine; Ondansetron; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Shrews

1992
Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:2

    Topics: Animals; Cocaine; Ethanol; Exploratory Behavior; Illicit Drugs; Imidazoles; Male; Mice; Nicotine; Ondansetron; Rats; Rats, Inbred Strains; Serotonin Antagonists; Social Behavior; Substance Withdrawal Syndrome

1990
Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron.
    Psychopharmacology, 1995, Volume: 118, Issue:1

    Topics: Amphetamine; Animals; Attention; Cerebral Cortex; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Male; Nicotine; Ondansetron; Parasympathetic Nervous System; Physostigmine; Prosencephalon; Rats; Reaction Time

1995
5HT3 receptor antagonists do not block nicotine induced hyperactivity in rats.
    Psychopharmacology, 1995, Volume: 119, Issue:2

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Granisetron; Haloperidol; Indoles; Male; Motor Activity; Nicotine; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Time Factors; Tropanes; Tropisetron

1995
The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmission.
    Journal of neural transmission. General section, 1993, Volume: 91, Issue:1

    Topics: Animals; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Hypothalamus; Male; Nicotine; Ondansetron; Rats; Receptors, Serotonin; Reward; Self Stimulation; Serotonin Antagonists; Synaptic Transmission

1993
Rat brain monoamine oxidase A and B inhibitory (tribulin) activity during drug withdrawal anxiety.
    Neuroscience letters, 1995, Oct-20, Volume: 199, Issue:2

    Topics: Animals; Anxiety; Brain; Brain Chemistry; Cannabis; Ethanol; Isatin; Isoenzymes; Lorazepam; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morphine; Nicotine; Ondansetron; Rats; Rats, Wistar; Substance Withdrawal Syndrome

1995
Attenuation of mecamylamine-precipitated nicotine-withdrawal aversion by the 5-HT3 receptor antagonist ondansetron.
    Life sciences, 1997, Volume: 61, Issue:16

    Topics: Animals; Conditioning, Psychological; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Substance Withdrawal Syndrome

1997
Nicotine-induced decreases in VTA electrical self-stimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron.
    Psychopharmacology, 1997, Volume: 134, Issue:2

    Topics: Animals; Conditioning, Operant; Dopamine Antagonists; Haloperidol; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ondansetron; Rats; Rats, Sprague-Dawley; Scopolamine; Self Stimulation; Serotonin Antagonists; Ventral Tegmental Area

1997
Abolishment of serotonergic neurotransmission to cardiac vagal neurons during and after hypoxia and hypercapnia with prenatal nicotine exposure.
    Journal of neurophysiology, 2009, Volume: 101, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Conotoxins; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agents; Female; Heart; Hypercapnia; Hypoxia; In Vitro Techniques; Male; Neurons; Nicotine; Nicotinic Antagonists; Ondansetron; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Serotonin; Serotonin Antagonists; Synaptic Transmission; Vagus Nerve; Valine

2009
Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012, Volume: 14, Issue:6

    Topics: Animals; Benzazepines; Dose-Response Relationship, Drug; Female; Genotype; Hexamethonium; Hypothermia; Inhibitory Concentration 50; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Motor Activity; Mutation; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ondansetron; Quinoxalines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Varenicline

2012
Serotonergic modulation of nicotine-induced kinetic tremor in mice.
    Journal of pharmacological sciences, 2017, Volume: 134, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Fenclonine; Humans; Male; Mice; Nicotine; Ondansetron; Piperazines; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists; Tremor

2017
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