nicotine has been researched along with nornicotine in 170 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (20.00) | 18.7374 |
| 1990's | 24 (14.12) | 18.2507 |
| 2000's | 47 (27.65) | 29.6817 |
| 2010's | 54 (31.76) | 24.3611 |
| 2020's | 11 (6.47) | 2.80 |
| Authors | Studies |
|---|---|
| Abood, LG; Kanne, DB | 1 |
| Caldwell, WS; Schmitt, JD; Sharples, CG | 1 |
| Damaj, MI; Dukat, M; Ferretti, G; Giannella, M; Glennon, RA; Martin, BR; Piergentili, A; Pigini, M; Quaglia, W | 1 |
| Casida, JE; Durkin, KA; Kanne, DB; Tomizawa, M | 1 |
| Banzi, R; Damaj, MI; Dukat, M; Glennon, RA; Martin, B; Ramunno, A | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Barfknecht, CF; Rosazza, JP; Sindelar, RD | 1 |
| Leete, E | 1 |
| Konishi, J; Magata, Y; Ohmomo, Y; Saji, H; Tajima, K; Yamada, Y; Yokoyama, A; Yonekura, Y | 1 |
| Bullion, K; Ohnishi, S; Osawa, Y | 1 |
| Adem, A; Copeland, JR; Jacob, P; Nordberg, A | 1 |
| Bullion, K; Nakabayashi, Y; Ohnishi, S; Osawa, G; Osawa, Y; Tochigi, B; Tochigi, M; Watanabe, Y; Yarborough, C | 1 |
| Benowitz, NL; Jacob, P; Zhang, Y | 1 |
| Garcha, HS; Goldberg, SR; Reavill, C; Risner, ME; Stolerman, IP | 1 |
| Goldberg, SR; Katz, JL; Swedberg, MD; Takada, K | 1 |
| Goldberg, SR; Katz, JL; Risner, ME | 1 |
| Benowitz, NL; Cone, EJ; Jacob, P; Risner, ME | 1 |
| DeMarco, GJ; Howard, PC; McCoy, GD | 1 |
| Dominiak, P; Fuchs, G; Grobecker, H; von Toth, S | 1 |
| Cone, EJ; Goldberg, SR; Prada, JA; Risner, ME | 1 |
| Andersen, RA; Kemp, TR | 1 |
| Riebe, M; Westphal, K | 1 |
| Blache, D; Dumont, E; Renaud, S; Thevenon, C; Wissendanger, T | 1 |
| Brune, H; Henrich, H; Hessenauer, A | 1 |
| Buxton, ST; Crooks, PA; Deo, N; Dwoskin, LP; Ravard, A; Teng, L | 1 |
| Arneric, SP; Brioni, JD; Buckley, MJ; Carrera, GM; Decker, MW; Garvey, DS; Holladay, MW; Sullivan, JP; Wasicak, JT; Williams, M | 1 |
| Brunnemann, KD; Djordjevic, MV; Hoffmann, D | 1 |
| Nordberg, A; Zhang, X | 1 |
| Buxton, ST; Crooks, PA; Dwoskin, LP; Jewell, AL | 1 |
| Bombick, BR; Doolittle, DJ; Fulp, C; Lee, CK | 1 |
| Crooks, PA; Dwoskin, LP; Li, M | 2 |
| Crooks, PA; Dwoskin, LP | 1 |
| Buxton, ST; Crooks, PA; Dwoskin, LP; Teng, L | 1 |
| Bardo, MT; Bevins, RA; Crooks, PA; Dwoskin, LP; Klebaur, JE | 1 |
| Linthicum, DS; Yong, T; Zheng, MQ | 1 |
| Ho, JW; Leung, YK | 1 |
| Bhatti, BS; Crooks, PA; Qureshi, MM; Swango, JH | 1 |
| Benowitz, NL; Jacob, P; Shulgin, AT; Yu, L | 1 |
| Bardo, MT; Crooks, PA; Dwoskin, LP; Green, TA; Teng, L | 1 |
| Bardo, MT; Crooks, PA; Dwoskin, LP; Green, TA | 2 |
| Crooks, PA; Dwoskin, LP; Ghosheh, O; Li, WK | 1 |
| Baldwin, IT; Laue, G; Preston, CA | 1 |
| Boye, SM; Clarke, PB | 1 |
| Bardo, MT; Crooks, PA; Dwoskin, LP; Green, TA; Phillips, SB | 1 |
| Crooks, PA; Dwoskin, LP; Ghosheh, OA; Miller, DK | 1 |
| Cormier, A; Lagrue, G; Morin, C; Tillement, JP; Zini, R | 1 |
| Foubelo, F; Soler, T; Yus, M | 1 |
| Galston, AW; Tiburcio, AF | 1 |
| Galston, AW; Ingersoll, R; Tiburcio, AF | 1 |
| Galston, AW; Kaur-Sawhney, R; Tiburcio, AF | 1 |
| Galston, AW; Ingersoll, RB; Kaur-Sawhney, R; Tiburcio, AF | 1 |
| Crooks, PA; Dwoskin, LP; Teng, LH | 1 |
| Dickerson, TJ; Janda, KD | 3 |
| Charlson, JR; Dale, LC; Ebbert, JO; Enger, RJ; Hurt, RD; Moyer, TP; Schroeder, DR | 1 |
| Berthelot, M; Gal, JF; Girard, S; Graton, J; Laurence, C; Le Questel, JY; Lebreton, J; Maria, PC; Naus, P | 1 |
| Bardo, MT; Brown, RW; Dwoskin, LP; Green, TA; Phillips, SB | 1 |
| Bottlaender, M; Coulon, C; Dollé, F; Ottaviani, M; Syrota, A; Valette, H | 1 |
| Benowitz, NL; Hall, S; Hatsukami, D; Jacob, P; Severson, H; Yu, L | 1 |
| GRIFFITH, RB; STOKES, GW; VALLEAU, WD | 1 |
| WADA, E | 1 |
| ENGELBRECHT, L; SCHROTER, HB | 1 |
| IHIDA, M; WADA, E | 1 |
| HUCKER, HB; LARSON, PS | 1 |
| KISAKI, T; TAMAKI, E | 2 |
| MATTILA, M; VARTIAINEN, A | 2 |
| BOWMAN, ER; McKENNIS, H; TURNBULL, LB; WADA, E | 1 |
| MATTILA, M | 1 |
| PAPADOPOULOS, NM | 1 |
| REES, AH; SCHNIEDEN, H | 1 |
| Berthelot, M; Gal, JF; Graton, J; Laurence, C; Le Questel, JY; Lebreton, J; Maria, PC; Robins, R | 1 |
| FEINSTEIN, L; McCABE, ET | 1 |
| Dickerson, TJ; Janda, KD; Lovell, T; Meijler, MM; Noodleman, L | 1 |
| Brogan, AP; Dickerson, TJ; Janda, KD; Rogers, CJ | 1 |
| Brown, KM; Murphy, SE; Raulinaitis, V | 1 |
| Boldt, GE; Brogan, AP; Dickerson, TJ; Janda, KD | 1 |
| Bhattacharyya, I; Caudle, RM; Cohen, DM; Katz, J; Stewart, CM | 1 |
| Aoki, Y; Fukami, T; Katoh, M; Nakajima, M; Nakamura, A; Sakai, H; Takamiya, M; Yamanaka, H; Yokoi, T | 1 |
| Bartholomeusz, TA; Bhogal, RK; Dräger, B; Felpin, FX; Lebreton, J; Mathé-Allainmat, M; Meier, AC; Mesnard, F; Molinié, R; Robins, RJ; Roscher, A | 1 |
| Bowen, SW; Dewey, RE; Gavilano, L; Siminszky, B | 1 |
| Ayers, JT; Crooks, PA; Dwoskin, LP; Xu, R | 1 |
| Bardo, MT; Boustany, C; Cassis, LA; Crooks, PA; Dwoskin, LP; Hojahmat, M; Neugebauer, NM; Stairs, DJ; Wei, X | 1 |
| Bowman, ML; Burnley, LE; Bush, L; Coleman, NP; Gavilano, LB; Hayes, A; Kalengamaliro, NE; Siminszky, B | 1 |
| Cass, WA; Crooks, PA; Dwoskin, LP; Middleton, LS; Wedlund, PJ | 1 |
| Crooks, PA; Dwoskin, LP; Papke, RL | 1 |
| Caudle, RM; Katz, J; Lamont, RJ; Mao, S; Yoon, TY | 1 |
| Chait, A; de Beaurepaire, R; Molimard, R; Rat, P; Touiki, K | 1 |
| Gonta, M; Hecht, SS; Li, ZZ; Porubin, D; Stepanov, I | 1 |
| Hsieh, SH; Huang, HY | 1 |
| Gavilano, LB; Siminszky, B | 1 |
| EISNER, A; SWAIN, ML | 1 |
| Gray, TR; Huestis, MA; Shakleya, DM | 1 |
| Chen, C; Liu, B; Su, Q; Wu, D | 1 |
| Brogan, AP; Dickerson, TJ; Janda, KD | 1 |
| Benowitz, NL; Dempsey, DA; Jacob, P; Kroetz, DL; Tutka, P | 1 |
| Gray, TR; Huestis, MA; Magri, R; Shakleya, DM | 1 |
| Fink, AL; Hong, DP; Uversky, VN | 1 |
| Dickerson, TJ; Janda, KD; Treweek, JB | 1 |
| Crooks, PA; Holtman, JR; Johnson-Hardy, JK; Wala, EP | 1 |
| Kushnir, MM; Rockwood, AL; Urry, FM; Yue, B | 1 |
| HICKS, CS; SINCLAIR, DA | 1 |
| Florek, E; Kulza, M; Loba, U; Piekoszewski, W; Wilimowska, J | 1 |
| Barr, JD; Bevins, RA; Murray, JE; Reichel, CM | 1 |
| Gu, GF; Lu, LL; Meng, XJ; Xiao, M | 1 |
| Bowen, SW; Dewey, RE; Keogh, MR; Lewis, RS | 1 |
| Baer, VL; Christensen, RD; Clark, CJ; Marin, SJ; McMillin, GA | 1 |
| Choonara, YE; du Toit, LC; Kumar, P; Modi, G; Naidoo, D; Pillay, V | 1 |
| Grata, E; Marclay, F; Perrenoud, L; Saugy, M | 1 |
| Miller, EI; Murray, GJ; Rollins, DE; Tiffany, ST; Wilkins, DG | 1 |
| Bawazeer, S; Knottenbelt, C; Watson, DG | 1 |
| Calas-List, D; List, O; Thany, SH | 1 |
| Hatsukami, DK; Hecht, SS; Knezevich, A; Muzic, J; Stepanov, I | 1 |
| Evans, SE; Hoffman, AC | 1 |
| Hashimoto, T; Pakdeechanuan, P; Shoji, T; Teoh, S | 1 |
| Bush, LP; Cai, B; Chappell, J; Dewey, RE; Siminszky, B | 1 |
| Bush, LP; Cai, B | 1 |
| Burkey, KO; Bush, LP; Conkling, MA; Fan, L; Holliday, BM; Hung, CY; Kittur, FS; Qiu, J; Roje, S; Sun, K; Tang, S; Xiao, B; Xie, J | 1 |
| Auerbach, A; Jadey, S; Purohit, P | 1 |
| Li, Y; Lin, X; Liu, S; Sun, Y; Xie, Z; Xu, D | 1 |
| Ceron-Carrasco, JP; Falaise, C; Graton, J; Jacquemin, D; Le Questel, JY; Leray, X; Quinchard, S; Thany, SH; Yassine, B | 1 |
| Bui, TT; Clayton, PM; Drake, AF; McAdam, K; Vas, CA | 1 |
| Kosewick, J; Wang, S; Yuan, C | 1 |
| Andrenyak, DM; Fleckenstein, AE; Nielsen, SM; Vieira-Brock, PL; Wilkins, DG | 1 |
| Bush, LP; Cai, B; Dewey, RE; Jack, AM; Lewis, RS | 1 |
| Gagat, M; Grzanka, A; Grzanka, D; Izdebska, M; Maczynska, E | 1 |
| Ande, A; Earla, R; Kumar, A; Kumar, S; McArthur, C | 1 |
| Caine, SB; Collins, GT; Lanier, RK; Mello, NK; Thomsen, M; Wright, C | 1 |
| Ansari, S; Buettner, A; Esposito, M; Gebel, S; Hoeng, J; Kogel, U; Leroy, P; Martin, F; Peitsch, MC; Schlage, WK; Vanscheeuwijck, P; Wyss, C; Xiang, Y | 1 |
| Farone, WA; Xantheas, SS; Yoshida, T | 1 |
| Billing, J; Kecili, R; Nivhede, D; Rees, A; Sellergren, B; Yilmaz, E | 1 |
| Craig, EL; Cui, JZ; Miksys, S; Novalen, M; Tyndale, RF; Zhao, B | 1 |
| Bernert, JT; Blount, BC; McGuffey, JE; Morrow, JC; Wang, L; Wei, B; Xia, B | 1 |
| Heyman, HM; Krüger, K; Marlin, D; Nicolson, SW; Stevenson, PC; Yusuf, AA | 1 |
| Fischer, L; Jantos, R; Mikus, F; Skopp, G | 1 |
| Chen, B; Hu, B; Li, XF; Qian, Y; Wu, M; Zhu, L | 1 |
| Banal, A; Cao, Q; Harris, AC; LeSage, MG; Muelken, P; Schmidt, CE; Tally, L | 1 |
| Bevins, RA; Dwoskin, LP; Pittenger, ST; Zeplin, LC | 1 |
| Ma, A; Wang, L; Zhang, Y; Zhao, B | 1 |
| Chen, Q; Lin, FC; Luo, ZP; Sun, B; Tang, HR; Wu, MZ; Xue, SL; Yang, J; Zhang, F | 1 |
| Ciesla, L; Dossou, KSS; Moaddel, R; Okine, M; Rosenberg, A; Toll, L; Wainer, IW | 1 |
| Donny, EC; Hatsukami, DK; Murphy, SE; Thomson, NM; von Weymarn, LB | 1 |
| Bergman, J; Desai, RI; Doyle, MR; Withey, SL | 1 |
| Geyer, H; Hedeland, M; Piper, T; Schänzer, W; Thevis, M; Thomas, A; Tretzel, L | 1 |
| Bush, LP; Cai, B; Fannin, FF; Ji, H | 1 |
| Qin, LJ; Zhao, D; Zhao, DG | 1 |
| He, J; Li, N; Liu, W; Lu, Z; Ma, Y; Niu, L; Qiu, J; Yang, Y | 1 |
| Bakaher, N; Bovet, L; Goepfert, S; Lang, G; Laparra, H; Liedschulte, V; Philippon, B; Schwaar, JD; Sierro, N; Vuarnoz, A | 1 |
| Heene, E; Maisch, J; Nick, P; Rajabi, F | 1 |
| Du Rand, EE; Lerch-Henning, S; Nicolson, SW | 1 |
| Bian, Z; Deng, H; Fan, Z; Li, Z; Liu, S; Tang, G; Wang, Y; Yang, F | 1 |
| Bloom, AJ; Kharasch, ED; Wang, PF | 1 |
| Helbling, FR; McHugh, D; Smart, DJ; Vanscheeuwijck, P; Verardo, M | 1 |
| Appel, H; Cocroft, R; Cossio-Rodríguez, R; Niemeyer, HM; Penna, M; Pinto, CF; Torrico-Bazoberry, D | 1 |
| Kotova, TI; Liu, H; Timko, MP | 1 |
| Gao, Y; Li, F; Li, M; Li, W; Liu, C; Song, Z; Sui, X; Wang, B; Yao, X; Zhao, L | 1 |
| Clarke, PBS; Huang, J; Wan, B; Wang, Y | 1 |
| Boddu, SH; Bolla, PK; Cudjoe, E; Gionfriddo, E; Godage, NH; Neupane, R; Renukuntla, J | 1 |
| Cai, B; Cai, K; Gao, W; Lei, B; Lin, Y; Pan, W; Wang, A; Wang, F; Yin, R; Zhao, H | 1 |
| Lu, Z; Najme, R; Qiu, J; Zhuang, S | 1 |
| Blake, JC; Coleman, DP; Gahl, RF; Jackson, KJ; Marusich, JA; Meredith, SE; Rehder Silinski, MA; Thomas, BF; Uenoyama, T | 1 |
| Chun, MR; Hwang, JH; Jee, JH; Lee, JY; Lee, SY; Oh, J; Park, MS | 1 |
| Arteaga, JF; González-Delgado, JA; Guzmán Ríos, D; Pischel, U; Romero, MA | 1 |
| Bai, G; Chen, X; Li, Y; Pang, T; Shi, J; Sui, X | 1 |
| Dang, B; Han, D; Huang, W; Huang, Y; Jia, W; Ma, S; Xu, Z; Zhang, K; Zhang, X; Zhang, Y; Zhao, F | 1 |
3 review(s) available for nicotine and nornicotine
| Article | Year |
|---|---|
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking.
Topics: Animals; Brain; Cotinine; Humans; Nicotine; Smoking | 1997 |
Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine.
Topics: Acetaldehyde; Anabasine; Animals; Cotinine; Dopamine; Humans; Mesencephalon; Nicotine; Smoking; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
1 trial(s) available for nicotine and nornicotine
| Article | Year |
|---|---|
Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy.
Topics: Adult; Alkaloids; Anabasine; Biomarkers; Chewing Gum; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nicotine; Probability; Prospective Studies; Pyridines; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Smoking; Tobacco Use Cessation; Tobacco Use Disorder; Tobacco, Smokeless; Treatment Outcome | 2002 |
166 other study(ies) available for nicotine and nornicotine
| Article | Year |
|---|---|
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
Topics: Animals; Brain; Carbachol; Electric Organ; Ganglionic Stimulants; In Vitro Techniques; Nicotine; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo; Tropanes | 1988 |
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.
Topics: Amino Acids; Ligands; Models, Molecular; Molecular Conformation; Quantum Theory; Receptors, Nicotinic; Structure-Activity Relationship | 1999 |
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors.
Topics: Humans; Molecular Mimicry; Neurons; Nicotine; Protein Binding; Receptors, Nicotinic; Structure-Activity Relationship | 2003 |
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Humans; Models, Molecular; Molecular Conformation; Nicotine; Protein Binding; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Tropanes | 2005 |
3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.
Topics: Crystallization; Drug Evaluation, Preclinical; Humans; Ligands; Molecular Structure; Nicotine; Protein Binding; Pyridines; Receptors, Nicotinic; Solvents; Structure-Activity Relationship | 2005 |
N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum.
Topics: Chemical Phenomena; Chemistry; Cyclic N-Oxides; Fermentation; Fungi; Microsporum; Nicotine; Oxidation-Reduction; Species Specificity | 1979 |
A new systematic degradation of nicotine to determine activity at C-2' and C-5'. The pattern of labeling in nicotine and nornicotine formed from (2-14C)ornithine in Nicotiana glutinosa, and in nicotine obtained from N. tabacum exposed to (14C, 13C)carbon
Topics: Carbon Dioxide; Isotope Labeling; Nicotiana; Nicotine; Ornithine; Plants, Toxic | 1976 |
Synthesis of (S)-N-[methyl-11C]nicotine and its regional distribution in the mouse brain: a potential tracer for visualization of brain nicotinic receptors by positron emission tomography.
Topics: Animals; Brain; Isotope Labeling; Male; Methylation; Mice; Nicotine; Receptors, Nicotinic; Stereoisomerism; Tomography, Emission-Computed | 1992 |
Competitive inhibition of human placental aromatase by N-n-octanoylnornicotine and other nornicotine derivatives.
Topics: Androstenedione; Aromatase Inhibitors; Binding, Competitive; Humans; Kinetics; Microsomes; Nicotine; Placenta; Smoking; Structure-Activity Relationship | 1991 |
A comparison of the binding of nicotine and nornicotine stereoisomers to nicotinic binding sites in rat brain cortex.
Topics: Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Male; Nicotine; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Stereoisomerism | 1991 |
Aromatase inhibitors in cigarette smoke, tobacco leaves and other plants.
Topics: Anabasine; Animals; Aromatase Inhibitors; Estrus; Female; Gas Chromatography-Mass Spectrometry; Humans; Nicotiana; Nicotine; Placenta; Plant Extracts; Plants, Toxic; Pregnancy; Rats; Rats, Inbred BUF; Smoke; Structure-Activity Relationship | 1990 |
Determination of nornicotine in smokers' urine by gas chromatography following reductive alkylation to N'-propylnornicotine.
Topics: Alkylation; Chemical Phenomena; Chemistry; Chromatography, Gas; Humans; Molecular Structure; Nicotine; Smoking | 1990 |
Nicotine and some related compounds: effects on schedule-controlled behaviour and discriminative properties in rats.
Topics: Animals; Conditioning, Operant; Cotinine; Discrimination, Psychological; Dose-Response Relationship, Drug; Insecticides; Male; Nicotine; Rats; Rats, Inbred F344; Reinforcement Schedule | 1989 |
Discriminative stimulus effects of intravenous l-nicotine and nicotine analogs or metabolites in squirrel monkeys.
Topics: Anabasine; Animals; Conditioning, Operant; Cotinine; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Nicotine; Reinforcement Schedule; Saimiri; Stereoisomerism | 1989 |
Behavioral pharmacology of licit drugs in experimental animals.
Topics: Animals; Caffeine; Conditioning, Psychological; Cotinine; Dogs; Nicotine; Rats; Reward; Saimiri | 1986 |
Effects of the stereoisomers of nicotine and nornicotine on schedule-controlled responding and physiological parameters of dogs.
Topics: Animals; Body Temperature; Conditioning, Psychological; Dogs; Heart Rate; Male; Nicotine; Pupil; Stereoisomerism | 1988 |
Characterization of hamster liver nicotine metabolism. I. Relative rates of microsomal C and N oxidation.
Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Cotinine; Cricetinae; Cyanides; Cysteamine; Male; Mesocricetus; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Oxidation-Reduction; Papain; Peptide Hydrolases; Proadifen | 1986 |
Effects of nicotine and its major metabolites on blood pressure in anaesthetized rats.
Topics: Animals; Blood Pressure; Cotinine; Dose-Response Relationship, Drug; Male; Nicotine; Rats; Rats, Inbred Strains | 1985 |
Effects of nicotine, cocaine and some of their metabolites on schedule-controlled responding by beagle dogs and squirrel monkeys.
Topics: Animals; Cocaine; Conditioning, Psychological; Cotinine; Dogs; Dose-Response Relationship, Drug; Female; Food; Male; Nicotine; Pyrrolidinones; Saimiri | 1985 |
Accumulation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone in alkaloid genotypes of burley tobacco during postharvest processing: comparisons with N'-nitrosonornicotine and probable nitrosamine precursors.
Topics: Alkaloids; Carcinogens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Time Factors | 1985 |
Studies on the induction of sister-chromatid exchanges in Chinese hamster ovary cells by various tobacco alkaloids.
Topics: Alkaloids; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; Insecticides; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; Mutation; Nicotiana; Nicotine; Ovary; Plants, Toxic; Pyridines; Sister Chromatid Exchange | 1983 |
Platelet function after cigarette smoking in relation to nicotine and carbon monoxide.
Topics: Adenosine Diphosphate; Adult; Blood Coagulation; Blood Platelets; Carbon Monoxide; Carboxyhemoglobin; Collagen; Epinephrine; Humans; Male; Middle Aged; Nicotine; Platelet Aggregation; Smoking; Thrombin | 1984 |
Microcirculatory effects of nicotine and related alkaloids.
Topics: Alkaloids; Animals; Dose-Response Relationship, Drug; Female; Insecticides; Male; Mesentery; Microcirculation; Muscles; Nicotine; Organ Specificity; Rats; Rats, Inbred Strains; Skin; Stereoisomerism; Vasoconstriction | 1984 |
Minor alkaloids of tobacco release [3H]dopamine from superfused rat striatal slices.
Topics: Anabasine; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Nicotine; Rats; Rats, Sprague-Dawley | 1995 |
Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Binding Sites; Brain; Bungarotoxins; Cognition; Isoxazoles; Mice; Molecular Structure; Motor Activity; Nicotine; Quinolizines; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Stereoisomerism | 1994 |
The need for regulation of carcinogenic N-nitrosamines in oral snuff.
Topics: Carcinogens; Legislation, Drug; Nicotine; Nitrosamines; Plants, Toxic; Sweden; Tobacco, Smokeless; United States | 1993 |
The competition of (-)-[3H]nicotine binding by the enantiomers of nicotine, nornicotine and anatoxin-a in membranes and solubilized preparations of different brain regions of rat.
Topics: Animals; Bacterial Toxins; Binding, Competitive; Brain; Cyanobacteria Toxins; In Vitro Techniques; Male; Marine Toxins; Microcystins; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Tropanes | 1993 |
S(-)-nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Calcium; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Nicotine; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tritium | 1993 |
Inhibition of mutagenicity of N-nitrosamines by tobacco smoke and its constituents.
Topics: Animals; Antimutagenic Agents; CHO Cells; Cotinine; Cricetinae; Dimethylnitrosamine; Dose-Response Relationship, Drug; Nicotine; Nitrosamines | 1996 |
Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine.
Topics: Animals; Brain; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Male; Nicotine; Rats; Rats, Sprague-Dawley; Tritium | 1995 |
Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine.
Topics: Administration, Cutaneous; Animals; Brain; Brain Chemistry; Cotinine; Male; Nicotine; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Nicotinic-receptor mediation of S(-)nornicotine-evoked -3H-overflow from rat striatal slices preloaded with -3H-dopamine.
Topics: Animals; Corpus Striatum; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Tritium | 1997 |
(-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats.
Topics: Animals; Central Nervous System Stimulants; Conditioning, Operant; Cues; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley | 1997 |
Nicotine induces leukocyte rolling and adhesion in the cerebral microcirculation of the mouse.
Topics: Administration, Topical; Animals; CD18 Antigens; Cell Adhesion; Cell Movement; Cerebral Veins; Cotinine; Endothelium, Vascular; Infusions, Intravenous; Insecticides; Leukocytes; Mice; Mice, Inbred Strains; Microcirculation; Nicotine; P-Selectin; Receptors, Cell Surface; Tachyphylaxis; Up-Regulation | 1997 |
Inhibitory effect of nicotine and its metabolites on tolbutamide hydroxylation in rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Cotinine; Fluorescence; Hydroxylation; Hypoglycemic Agents; Microsomes, Liver; Molecular Structure; Nicotine; Rats; Sensitivity and Specificity; Smoking; Tolbutamide | 1998 |
A novel enantioselective synthesis of (S)-(-)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketimine template.
Topics: Alkylation; Indicators and Reagents; Models, Molecular; Molecular Conformation; Molecular Structure; Nicotine; Pyridines; Stereoisomerism | 1999 |
Minor tobacco alkaloids as biomarkers for tobacco use: comparison of users of cigarettes, smokeless tobacco, cigars, and pipes.
Topics: Adult; Alkaloids; Anabasine; Biomarkers; Cotinine; Humans; Male; Middle Aged; Nicotiana; Nicotine; Nicotinic Agonists; Plants, Toxic; Pyridines; Reproducibility of Results; Smoking; Substance Abuse Detection; Time Factors; Tobacco Use Disorder | 1999 |
Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Dose-Response Relationship, Drug; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1999 |
Nornicotine is self-administered intravenously by rats.
Topics: Animals; Dose-Response Relationship, Drug; Male; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Stereoisomerism | 1999 |
Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine.
Topics: Animals; Brain; Carbon Radioisotopes; Cotinine; Gas Chromatography-Mass Spectrometry; Half-Life; Male; Nicotine; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Fast track to the trichome: induction of N-acyl nornicotines precedes nicotine induction in Nicotiana repanda.
Topics: Acetates; Cyclopentanes; Nicotiana; Nicotine; Nitrates; Oxylipins; Plant Growth Regulators; Plant Structures; Plants, Toxic | 2000 |
Enhancement of haloperidol-induced catalepsy by nicotine: an investigation of possible mechanisms.
Topics: Animals; Catalepsy; Chlorisondamine; Cotinine; Dopamine Antagonists; Drug Synergism; Haloperidol; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley | 2000 |
Nornicotine pretreatment decreases intravenous nicotine self-administration in rats.
Topics: Animals; Dose-Response Relationship, Drug; Male; Nicotine; Rats; Rats, Sprague-Dawley; Self Administration | 2000 |
Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine.
Topics: Animals; Brain; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cotinine; Male; Nicotine; Radiometry; Rats; Rats, Sprague-Dawley | 2001 |
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anthraquinones; Antimycin A; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cotinine; Electron Transport Complex I; Electron Transport Complex II; Hexamethonium; Male; Membrane Proteins; Mitochondria; Mitochondrial Proton-Translocating ATPases; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Neuroprotective Agents; Nicotine; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Oxygen Consumption; Prosencephalon; Pyridines; Quinolizines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Nicotinic; Rotenone; Succinate Dehydrogenase; Superoxides; Synaptosomes | 2001 |
A new and direct synthesis of 2-substituted pyrrolidines.
Topics: Aldehydes; Nicotine; Propylamines; Pyrrolidines | 2001 |
Arginine decarboxylase as the source of putrescine for tobacco alkaloids.
Topics: Alkaloids; Arginine; Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Nicotiana; Nicotine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Putrescine; Pyrrolidines | 1986 |
Modified alkaloid pattern in developing tobacco callus.
Topics: Alkaloids; Anabasine; Carboxylic Acids; Citric Acid; Culture Media; Culture Techniques; Fumarates; Malates; Nicotiana; Nicotine; Plant Roots; Plants, Toxic; Pyridines; Pyrrolidines; Pyruvic Acid | 1985 |
Effect of polyamine biosynthetic inhibitors on alkaloids and organogenesis in tobacco callus cultures.
Topics: Arginine; Biomass; Carboxy-Lyases; Culture Techniques; Cyclohexylamines; Eflornithine; Enzyme Inhibitors; Nicotiana; Nicotine; Ornithine Decarboxylase Inhibitors; Plant Roots; Plants, Toxic; Polyamines; Putrescine; Spermidine; Spermidine Synthase | 1987 |
Correlation between polyamines and pyrrolidine alkaloids in developing tobacco callus.
Topics: Alkaloids; Biogenic Polyamines; Carboxy-Lyases; Culture Media; Naphthaleneacetic Acids; Nicotiana; Nicotine; Ornithine Decarboxylase; Plants, Toxic; Putrescine; Pyrrolidines; Spermidine | 1985 |
Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices.
Topics: Analysis of Variance; Animals; Calcium; Dihydro-beta-Erythroidine; Dopamine; In Vitro Techniques; Insecticides; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Smoking; Tritium | 2001 |
Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum.
Topics: Animals; Buffers; Dopamine; In Vitro Techniques; Male; Neostriatum; Nicotiana; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism | 2001 |
Aqueous aldol catalysis by a nicotine metabolite.
Topics: Acetone; Benzaldehydes; Catalysis; Kinetics; Nicotine; Proline; Pyrrolidines; Substrate Specificity; Water | 2002 |
Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles.
Topics: Adult; Alkaloids; Anabasine; Cotinine; Female; Humans; Male; Mass Spectrometry; Middle Aged; Nicotiana; Nicotine; Reference Values; Substance Abuse Detection | 2002 |
Site of protonation of nicotine and nornicotine in the gas phase: pyridine or pyrrolidine nitrogen?
Topics: Binding Sites; Gases; Models, Chemical; Models, Molecular; Molecular Conformation; Nicotine; Nitrogen; Protons; Static Electricity; Thermodynamics | 2002 |
Locomotor stimulant effects of nornicotine: role of dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Drug Synergism; Male; Motor Activity; Nicotine; Nucleus Accumbens; Oxidopamine; Rats; Rats, Sprague-Dawley; Salicylamides; Stimulation, Chemical; Sympathectomy, Chemical; Sympatholytics | 2002 |
A previously undescribed chemical link between smoking and metabolic disease.
Topics: Glycation End Products, Advanced; Glycosylation; Humans; Metabolic Diseases; Nicotine; Smoking | 2002 |
Long-lasting occupancy of central nicotinic acetylcholine receptors after smoking: a PET study in monkeys.
Topics: Animals; Brain; Injections, Intravenous; Male; Nicotine; Nicotinic Agonists; Papio; Receptors, Nicotinic; Reference Values; Smoking; Tissue Distribution; Tomography, Emission-Computed | 2003 |
Glycation of the amyloid beta-protein by a nicotine metabolite: a fortuitous chemical dynamic between smoking and Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Glucose; Glycosylation; Humans; Lysine; Molecular Sequence Data; Neuroprotective Agents; Nicotine; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Peptide Fragments; Smoking; Solubility | 2003 |
Determination and inheritance of nicotine to nornicotine conversion in tobacco.
Topics: Biochemical Phenomena; Databases, Genetic; Nicotiana; Nicotine | 1955 |
Conversion of nicotine to nornicotine in cherry red tobacco during flue-curing.
Topics: Nicotiana; Nicotine; Prunus | 1956 |
[Demonstration of nornicotine production in isolated tobacco root].
Topics: Nicotiana; Nicotine | 1957 |
The enzymic oxidation of chlorogenic and caffeic acids in the presence of nornicotine.
Topics: Acids; Caffeic Acids; Nicotine; Oxidation-Reduction; Oxidoreductases | 1957 |
Studies on the metabolism of nornicotine in the dog.
Topics: Animals; Dogs; Nicotine | 1958 |
Phytochemical studies on the tobacco alkaloids. I. Optical rotatory power of nornicotine.
Topics: Alkaloids; Nicotiana; Nicotine | 1961 |
Phytochemical studies on the tobacco alkaloids. III. Observations on the interconversion of DL-nicotine and DL-nornicotine in excised tobacco leaves.
Topics: Alkaloids; Biochemical Phenomena; Nicotiana; Nicotine | 1961 |
The lethaldose, pressor effect and intestinal activity of some pyrrolidine N-substituted Nornicotine derivatives.
Topics: Alkaloids; Blood Pressure; Humans; Muscle, Smooth; Muscles; Nicotine; Pyrrolidines; Vasoconstrictor Agents | 1962 |
Norcotinine (desmethylcotinine) as a urinary metabolite of nornicotine.
Topics: Cotinine; Humans; Nicotine | 1961 |
PHARMACOLOGICAL PROPERTIES OF SOME PYRROLIDINE N-SUBSTITUTED NORNICOTINE DERIVATIVES.
Topics: Alkaloids; Animals; Anura; Blood Pressure; Blood Pressure Determination; Cats; Cholinesterases; Ganglia; Ganglia, Autonomic; Guinea Pigs; Intestine, Small; Intestines; Muscle, Smooth; Muscles; Myocardium; Nicotine; Pharmacology; Poultry; Pyridines; Pyrroles; Pyrrolidines; Research; Toxicology | 1963 |
THE VASOCONSTRICTOR ACTION OF SOME NORNICOTINE DERIVATIVES.
Topics: Acetylcholine; Blood Vessels; Epinephrine; Nicotine; Pharmacology; Phentolamine; Rabbits; Rats; Research; Reserpine; Thiamine; Tolazoline; Vasoconstrictor Agents | 1964 |
FORMATION OF NORNICOTINE AND OTHER METABOLITES FROM NICOTINE IN VITRO AND IN VIVO.
Topics: Animals; Chromatography; Formaldehyde; In Vitro Techniques; Injections; Injections, Intravenous; Kidney; Liver; Liver Extracts; Metabolism; Nicotine; Rabbits; Research; Tissue Extracts; Urine | 1964 |
Effects of nicorine, nornicotine and allylnornicotine on the diuretic response to water in rats.
Topics: Animals; Diuresis; Diuretics; Mice; Nicotine; Rats; Water | 1962 |
The nicotinic pharmacophore: thermodynamics of the hydrogen-bonding complexation of nicotine, nornicotine, and models.
Topics: Hydrogen Bonding; Models, Molecular; Molecular Structure; Nicotine; Pyridines; Pyrrolidines; Spectroscopy, Fourier Transform Infrared; Thermodynamics | 2003 |
New tests for the Nicotiana alkaloids, nornicotine and anabasine.
Topics: Alkaloids; Anabasine; Humans; Nicotiana; Nicotine | 1950 |
Nornicotine aqueous aldol reactions: synthetic and theoretical investigations into the origins of catalysis.
Topics: Catalysis; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Structure; Nicotine | 2004 |
Hammett correlation of nornicotine analogues in the aqueous aldol reaction: implications for green organocatalysis.
Topics: Catalysis; Indicators and Reagents; Kinetics; Molecular Structure; Nicotine; Pyrrolidines; Stereoisomerism; Water | 2005 |
Nicotine 5'-oxidation and methyl oxidation by P450 2A enzymes.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cotinine; Cytochrome P-450 CYP2A6; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Nitrosamines; Smoking; Steroid Hydroxylases; Tritium | 2005 |
Altered retinoid homeostasis catalyzed by a nicotine metabolite: implications in macular degeneration and normal development.
Topics: Catalysis; Chromatography, High Pressure Liquid; Gene Expression Regulation; Isomerism; Macular Degeneration; Nicotine; Retinoids; Smoking | 2005 |
Receptor for advanced glycation end product (RAGE) upregulation in human gingival fibroblasts incubated with nornicotine.
Topics: Cell Line; Fibroblasts; Gingiva; Glycation End Products, Advanced; Humans; Inflammation Mediators; Nicotine; Periodontal Diseases; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smoking; Up-Regulation | 2005 |
CYP2A6 AND CYP2B6 are involved in nornicotine formation from nicotine in humans: interindividual differences in these contributions.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Corpus Striatum; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Dealkylation; Humans; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Oxidoreductases, N-Demethylating | 2005 |
Nicotine demethylation in Nicotiana cell suspension cultures: N'-formylnornicotine is not involved.
Topics: Alkaloids; Cell Culture Techniques; Cells, Cultured; Cotinine; Gas Chromatography-Mass Spectrometry; Methylation; Nicotiana; Nicotine; Nitrogen Isotopes | 2005 |
Conversion of nicotine to nornicotine in Nicotiana tabacum is mediated by CYP82E4, a cytochrome P450 monooxygenase.
Topics: Base Sequence; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA Primers; Expressed Sequence Tags; Gene Library; Microarray Analysis; Mixed Function Oxygenases; Molecular Sequence Data; Nicotiana; Nicotine; Plants, Genetically Modified; RNA Interference; Sequence Analysis, DNA; Yeasts | 2005 |
A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine.
Topics: Alkaloids; Anabasine; Nicotiana; Nicotine; Pyridines; Stereoisomerism | 2005 |
Re: Receptor for advanced glycation end product (RAGE) upregulation in human gingival fibroblasts incubated with nornicotine. Katz J, Caudle RM, Bhattacharyya I, Stewart CM, Cohen DM (2005;76:1171-1174).
Topics: Cell Line; Fibroblasts; Gingiva; Glycation End Products, Advanced; Humans; Membrane Proteins; Nicotine; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Smoking; Up-Regulation | 2006 |
Effects of nornicotine enantiomers on intravenous S(-)-nicotine self-administration and cardiovascular function in rats.
Topics: Animals; Appetitive Behavior; Biological Availability; Blood Pressure; Dopamine; Dose-Response Relationship, Drug; Heart Rate; Infusions, Intravenous; Male; Motivation; Nicotine; Nucleus Accumbens; Rats; Self Administration; Stereoisomerism; Structure-Activity Relationship; Tobacco Use Disorder | 2007 |
Genetic engineering of Nicotiana tabacum for reduced nornicotine content.
Topics: Cytochrome P-450 Enzyme System; DNA Primers; Humans; Nicotiana; Nicotine; Plant Leaves; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2006 |
Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Insecticides; Male; Mecamylamine; Metabolic Clearance Rate; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission; Time Factors; Tobacco Use Disorder | 2007 |
The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Brain Chemistry; Female; Gene Transfer Techniques; Humans; Nicotine; Nicotinic Agonists; Oocytes; Protein Subunits; Rats; Receptors, Nicotinic; Recombinant Fusion Proteins; Tobacco Use Disorder; Xenopus | 2007 |
Expression of the receptor of advanced glycation end products in the gingival tissue of smokers with generalized periodontal disease and after nornicotine induction in primary gingival epithelial cells.
Topics: Adult; Aged; Epidemiologic Methods; Epithelial Cells; Female; Gingiva; Humans; Male; Middle Aged; Nicotine; Periodontal Diseases; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Messenger; Smoking | 2007 |
Effects of tobacco and cigarette smoke extracts on serotonergic raphe neurons in the rat.
Topics: Anabasine; Animals; Citalopram; Data Interpretation, Statistical; Electrophysiology; Male; Neurons; Nicotiana; Nicotine; Plant Extracts; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Smoke | 2007 |
Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract.
Topics: Animals; Antioxidants; Carcinogens; Male; Nicotine; Nitrosamines; Plant Extracts; Rats; Rats, Inbred F344; Seeds; Sodium Nitrite; Vitis | 2007 |
Analyses of tobacco alkaloids by cation-selective exhaustive injection sweeping microemulsion electrokinetic chromatography.
Topics: Alkaloids; Anabasine; Chromatography, Micellar Electrokinetic Capillary; Molecular Structure; Nicotiana; Nicotine; Pyridines; Reproducibility of Results | 2007 |
Isolation and characterization of the cytochrome P450 gene CYP82E5v2 that mediates nicotine to nornicotine conversion in the green leaves of tobacco.
Topics: Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Genotype; Nicotiana; Nicotine; Plant Leaves; Plant Proteins | 2007 |
Ultraviolet absorption spectra of nicotine, nornicotine and some of their derivatives.
Topics: Morphine; Nicotine; Spectrum Analysis | 1949 |
Quantification of nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry.
Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Cotinine; Female; Humans; Indicators and Reagents; Infant, Newborn; Mass Spectrometry; Meconium; Nicotine; Pregnancy; Quality Control; Reference Standards; Smoking; Tandem Mass Spectrometry | 2008 |
Enantiomeric analysis of anatabine, nornicotine and anabasine in commercial tobacco by multi-dimensional gas chromatography and mass spectrometry.
Topics: Alkaloids; Anabasine; Gas Chromatography-Mass Spectrometry; Nicotiana; Nicotine; Pyridines; Stereoisomerism | 2008 |
Nornicotine-organocatalyzed aqueous reduction of alpha,beta-unsaturated aldehydes.
Topics: Aldehydes; Catalysis; Dimethyl Sulfoxide; NAD; Nicotine; Oxidation-Reduction; Solutions; Water | 2007 |
Nicotine metabolism in pregnant and nonpregnant rabbits.
Topics: Animals; Blotting, Western; Cotinine; Cytochrome P-450 CYP2D6; Female; Microsomes, Liver; Nicotine; Pregnancy; Pregnancy, Animal; Rabbits | 2008 |
Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures.
Topics: Apgar Score; Biomarkers; Body Size; Chromatography, Liquid; Cotinine; Female; Gestational Age; Glucuronates; Humans; Hydrolysis; Infant, Newborn; Maternal Exposure; Maternal-Fetal Exchange; Meconium; Nicotine; Pregnancy; Smoking; Tandem Mass Spectrometry; Tobacco Smoke Pollution | 2008 |
Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?
Topics: alpha-Synuclein; Amino Acid Sequence; Anabasine; Benzothiazoles; Chromatography, Gel; Cotinine; Humans; Hydroquinones; Microscopy, Atomic Force; Molecular Sequence Data; Mutation; Nicotine; Parkinson Disease; Protein Binding; Protein Multimerization; Smoking; Thiazoles | 2009 |
Drugs of abuse that mediate advanced glycation end product formation: a chemical link to disease pathology.
Topics: Alzheimer Disease; Atherosclerosis; Diabetes Mellitus; Disease; Glycation End Products, Advanced; Humans; Macular Degeneration; Methamphetamine; Molecular Structure; Neoplasms; Nicotine | 2009 |
The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.
Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Drug Interactions; Male; Morphine; Motor Activity; Nicotine; Pain; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2010 |
Quantitation of nicotine, its metabolites, and other related alkaloids in urine, serum, and plasma using LC-MS-MS.
Topics: Alkaloids; Anabasine; Chromatography, Liquid; Cotinine; Humans; Nicotine; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2010 |
Toxicities of the optical isomers of nicotine and nornicotine.
Topics: Isomerism; Nicotine | 1947 |
[Development of analytical method for determination nicotine metabolites in urine].
Topics: Biomarkers; Chromatography, High Pressure Liquid; Cotinine; Cyclic N-Oxides; Environmental Exposure; Environmental Monitoring; Humans; Nicotine; Predictive Value of Tests | 2009 |
Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.
Topics: Animals; Benzazepines; Conditioning, Classical; Discrimination, Psychological; Extinction, Psychological; Generalization, Psychological; Isoxazoles; Ligands; Male; Nicotine; Nicotinic Agonists; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Varenicline | 2010 |
A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves.
Topics: Alkaloids; Aspergillus oryzae; Biodegradation, Environmental; DNA, Ribosomal; DNA, Ribosomal Spacer; Gas Chromatography-Mass Spectrometry; Metabolic Networks and Pathways; Models, Biological; Niacinamide; Nicotiana; Nicotine; Plant Leaves; Pyridines; RNA, Ribosomal, 18S | 2010 |
Three nicotine demethylase genes mediate nornicotine biosynthesis in Nicotiana tabacum L.: functional characterization of the CYP82E10 gene.
Topics: Carcinogens; Cytochrome P-450 Enzyme System; Molecular Structure; Nicotiana; Nicotine; Nitrosamines; Plant Leaves; Plant Proteins | 2010 |
Nicotine and metabolites in paired umbilical cord tissue and meconium specimens.
Topics: Anabasine; Central Nervous System Stimulants; Cotinine; Female; Humans; Infant, Newborn; Maternal Exposure; Maternal-Fetal Exchange; Meconium; Nicotine; Pregnancy; Smoking; Umbilical Cord | 2011 |
In silico theoretical molecular modeling for Alzheimer's disease: the nicotine-curcumin paradigm in neuroprotection and neurotherapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Computational Biology; Curcumin; Humans; Neuroprotective Agents; Nicotine | 2011 |
A one-year monitoring of nicotine use in sport: frontier between potential performance enhancement and addiction issues.
Topics: Alkaloids; Anabasine; Athletes; Chromatography, Liquid; Cotinine; Doping in Sports; Humans; Mass Spectrometry; Nicotine; Performance-Enhancing Substances; Pyridines; Smoking; Spectrometry, Mass, Electrospray Ionization; Tobacco, Smokeless | 2011 |
Validation of a liquid chromatography-tandem mass spectrometry method for the detection of nicotine biomarkers in hair and an evaluation of wash procedures for removal of environmental nicotine.
Topics: Biomarkers; Chromatography, Liquid; Cotinine; Hair; Humans; Limit of Detection; Nicotine; Tandem Mass Spectrometry; Tobacco Smoke Pollution | 2011 |
Determination of nicotine exposure in dogs subjected to passive smoking using methanol extraction of hair followed by hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry.
Topics: Animals; Calibration; Chemical Fractionation; Chromatography, Liquid; Cotinine; Deuterium; Dogs; Hair; Hydrophobic and Hydrophilic Interactions; Methanol; Nicotine; Oxidation-Reduction; Sodium Hydroxide; Solvents; Sonication; Spectroscopy, Fourier Transform Infrared; Tobacco Smoke Pollution | 2012 |
Nornicotine application on cockroach dorsal unpaired median neurons induces two distinct ionic currents: implications of different nicotinic acetylcholine receptors.
Topics: Acetylcholine; Animals; Bungarotoxins; Cells, Cultured; Cockroaches; Drug Interactions; Neurons; Nicotine; Receptors, Muscarinic; Receptors, Nicotinic; Tubocurarine | 2012 |
Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans.
Topics: Humans; Nicotine; Nitrosamines; Nitrosation; Saliva; Smoking; Smoking Cessation | 2013 |
Non-functionalization of two CYP82E nicotine N-demethylase genes abolishes nornicotine formation in Nicotiana langsdorffii.
Topics: Alkaloids; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Plant; Gene Frequency; Genotype; Mixed Function Oxygenases; Nicotiana; Nicotine; Phenotype; Phylogeny; Plant Leaves; Plant Proteins; Plant Roots; Sequence Deletion; Species Specificity; Transcriptional Activation | 2012 |
Enantioselective demethylation of nicotine as a mechanism for variable nornicotine composition in tobacco leaf.
Topics: Alkaloids; Biosynthetic Pathways; Cytochrome P-450 Enzyme System; Kinetics; Methylation; Models, Biological; Nicotiana; Nicotine; Plant Leaves; Plant Proteins; Stereoisomerism; Substrate Specificity | 2012 |
Variable nornicotine enantiomeric composition caused by nicotine demethylase CYP82E4 in tobacco leaf.
Topics: Cytochrome P-450 Enzyme System; Nicotiana; Nicotine; Plant Leaves; Plant Proteins; Stereoisomerism | 2012 |
Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation.
Topics: Alkaloids; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA, Complementary; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Immunoblotting; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Molecular Sequence Data; Nicotiana; Nicotine; Plant Leaves; Plant Proteins; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 2013 |
Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153.
Topics: Anabasine; Dose-Response Relationship, Drug; Glycine; HEK293 Cells; Humans; Ion Channel Gating; Kidney; Lysine; Mutation; Nicotine; Patch-Clamp Techniques; Receptors, Cholinergic; Serine | 2013 |
Sensitive capillary electrophoretic profiling of nicotine and nornicotine in mushrooms with amperometric detection.
Topics: Agaricales; Electrophoresis, Capillary; Limit of Detection; Nicotine | 2013 |
Pretreatment of the cockroach cercal afferent/giant interneuron synapses with nicotinoids and neonicotinoids differently affects acetylcholine and nicotine-induced ganglionic depolarizations.
Topics: Acetylcholine; Action Potentials; Animals; Cockroaches; Cotinine; Imidazoles; Insecticides; Interneurons; Neonicotinoids; Nicotine; Nitro Compounds; Synapses | 2013 |
Spectroscopic studies on nicotine and nornicotine in the UV region.
Topics: Nicotine; Spectrophotometry, Ultraviolet | 2013 |
A simple, fast, and sensitive method for the measurement of serum nicotine, cotinine, and nornicotine by LC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Cotinine; Humans; Nicotine; Tandem Mass Spectrometry; Time Factors | 2013 |
Age-related differences in the disposition of nicotine and metabolites in rat brain and plasma.
Topics: Administration, Cutaneous; Adolescent; Adult; Aging; Animals; Brain; Cotinine; Cyclic N-Oxides; Humans; Male; Nicotine; Rats; Rats, Sprague-Dawley | 2013 |
(R)-nicotine biosynthesis, metabolism and translocation in tobacco as determined by nicotine demethylase mutants.
Topics: Biological Transport; Cytochrome P-450 Enzyme System; Methylation; Mutation; Nicotiana; Nicotine; Plant Leaves; Plant Proteins; Plant Roots | 2013 |
Nornicotine impairs endothelial cell-cell adherens junction complexes in EA.hy926 cell line via structural reorganization of F-actin.
Topics: Actins; Adherens Junctions; Cell Line; Cell Movement; Endothelial Cells; Endothelium, Vascular; Humans; Nicotine; Polymerization; Protein Binding; Weibel-Palade Bodies; Zonula Occludens-1 Protein | 2013 |
Enhanced nicotine metabolism in HIV-1-positive smokers compared with HIV-negative smokers: simultaneous determination of nicotine and its four metabolites in their plasma using a simple and sensitive electrospray ionization liquid chromatography-tandem ma
Topics: Adult; Biotransformation; Cotinine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Reproducibility of Results; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Up-Regulation | 2014 |
Nicotine-like behavioral effects of the minor tobacco alkaloids nornicotine, anabasine, and anatabine in male rodents.
Topics: Alkaloids; Anabasine; Animals; Behavior, Animal; Discrimination Learning; Dose-Response Relationship, Drug; Male; Mice; Nicotiana; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome | 2014 |
A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Carboxyhemoglobin; Cell Differentiation; Chemokines; Cotinine; Cytokines; Endpoint Determination; Female; Inhalation Exposure; Lung; Male; Nicotiana; Nicotine; Organ Size; Rats; Rats, Sprague-Dawley; Respiratory Mucosa; Risk Assessment; Risk Factors; Tobacco Products; Transcriptome | 2014 |
Isomers and conformational barriers of gas-phase nicotine, nornicotine, and their protonated forms.
Topics: Gases; Isomerism; Molecular Conformation; Nicotine; Thermodynamics | 2014 |
Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries.
Topics: Aminopyridines; Carcinogens; Drug Contamination; Molecular Imprinting; Nicotine; Pharmaceutical Preparations; Piroxicam; Polymers | 2014 |
Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data.
Topics: Animals; Area Under Curve; Brain; Cotinine; Cyclic N-Oxides; Male; Models, Animal; Nicotine; Plasma; Rats; Rats, Wistar | 2014 |
Validation of a LC-MS/MS method for quantifying urinary nicotine, six nicotine metabolites and the minor tobacco alkaloids--anatabine and anabasine--in smokers' urine.
Topics: Alkaloids; Anabasine; Chromatography, Liquid; Cotinine; Humans; Nicotine; Pyridines; Smoking; Tandem Mass Spectrometry | 2014 |
The only African wild tobacco, Nicotiana africana: alkaloid content and the effect of herbivory.
Topics: Africa; Alkaloids; Anabasine; Animals; Flowers; Herbivory; Larva; Moths; Nicotiana; Nicotine; Plant Leaves | 2014 |
Simultaneous quantification of tobacco alkaloids and major phase I metabolites by LC-MS/MS in human tissue.
Topics: Alkaloids; Anabasine; Animals; Brain Chemistry; Cattle; Chickens; Chromatography, Liquid; Ganglionic Stimulants; Humans; Liver; Lung; Muscle, Skeletal; Nicotiana; Nicotine; Pyridines; Smoking; Solid Phase Extraction; Swine; Tandem Mass Spectrometry; Tissue Distribution | 2015 |
Identification of precursors and mechanisms of tobacco-specific nitrosamine formation in water during chloramination.
Topics: Alkaloids; Chloramines; Chromatography, Liquid; Drinking Water; Halogenation; Mass Spectrometry; Nicotiana; Nicotine; Nitrosamines; Pyridines; Solid Phase Extraction; Tandem Mass Spectrometry; Water Pollutants, Chemical | 2015 |
Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats.
Topics: Alkaloids; Anabasine; Animals; Brain; Cotinine; Male; Nicotine; Pyridines; Rats; Self Stimulation | 2015 |
The effect of switching pharmacological intervention during extinction on nicotine-evoked conditioned responding in rats.
Topics: Animals; Conditioning, Psychological; Discrimination Learning; Dose-Response Relationship, Drug; Drug Substitution; Extinction, Psychological; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Smoking Cessation; Varenicline | 2015 |
Nornicotine and Nicotine Induced Neovascularization via Increased VEGF/PEDF Ratio.
Topics: Blood Vessels; Blotting, Western; Cell Line; Cell Movement; Cell Proliferation; Eye Proteins; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Nerve Growth Factors; Nicotine; Nicotinic Agonists; Real-Time Polymerase Chain Reaction; Retinal Pigment Epithelium; RNA, Messenger; Serpins; Vascular Endothelial Growth Factor A | 2015 |
A Quantitative Real-Time PCR-Based Strategy for Molecular Evaluation of Nicotine Conversion in Burley Tobacco.
Topics: Evolution, Molecular; Gas Chromatography-Mass Spectrometry; Nicotiana; Nicotine; Real-Time Polymerase Chain Reaction | 2015 |
Development and characterization of the α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts.
Topics: Alkaloids; Anabasine; Binding Sites; Chemistry Techniques, Analytical; Chromatography, Affinity; Fabaceae; Lycopodiaceae; Nicotine; Plant Extracts; Receptors, Nicotinic; Smoke | 2016 |
Quantitation of the Minor Tobacco Alkaloids Nornicotine, Anatabine, and Anabasine in Smokers' Urine by High Throughput Liquid Chromatography-Mass Spectrometry.
Topics: Adolescent; Alkaloids; Anabasine; Chromatography, High Pressure Liquid; Humans; Molecular Structure; Nicotiana; Nicotine; Pyridines; Smoking; Tandem Mass Spectrometry | 2016 |
Nicotinic effects of tobacco smoke constituents in nonhuman primates.
Topics: Alkaloids; Anabasine; Animals; Behavior, Addictive; Behavior, Animal; Cotinine; Dose-Response Relationship, Drug; Male; Nicotiana; Nicotine; Pyridines; Saimiri; Smoke | 2016 |
Fully automated determination of nicotine and its major metabolites in whole blood by means of a DBS online-SPE LC-HR-MS/MS approach for sports drug testing.
Topics: Alkaloids; Anabasine; Automation; Chromatography, Liquid; Cotinine; Doping in Sports; Dried Blood Spot Testing; Electronic Nicotine Delivery Systems; Female; Humans; Male; Nicotine; Online Systems; Pyridines; Reproducibility of Results; Solid Phase Extraction; Sports; Substance Abuse Detection; Tandem Mass Spectrometry | 2016 |
Contribution of Nicotine and Nornicotine toward the Production of N'-Nitrosonornicotine in Air-Cured Tobacco (Nicotiana tabacum).
Topics: Alkaloids; Carcinogens; Molecular Structure; Nicotiana; Nicotine; Nitrosamines; North Carolina; Plant Leaves; Stereoisomerism | 2016 |
RNA interference of the nicotine demethylase gene CYP82E4v1 reduces nornicotine content and enhances Myzus persicae resistance in Nicotiana tabacum L.
Topics: Animals; Antioxidants; Aphids; Cyclopentanes; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Plant; Genes, Plant; Genetic Vectors; Nicotiana; Nicotine; Oxylipins; Phenylalanine Ammonia-Lyase; Plant Growth Regulators; Plant Proteins; Plants, Genetically Modified; Real-Time Polymerase Chain Reaction; RNA Interference; Salicylic Acid; Signal Transduction | 2016 |
Conversion of nornicotine to 6-hydroxy-nornicotine and 6-hydroxy-myosmine by Shinella sp. strain HZN7.
Topics: Alkaloids; Biotransformation; Cloning, Molecular; Insecticides; Nicotine; Oxidoreductases Acting on CH-NH Group Donors; Rhizobiaceae; Spectrum Analysis | 2016 |
Identification of CYP82E21 as a functional nicotine N-demethylase in tobacco flowers.
Topics: Cytochrome P-450 Enzyme System; Flowers; Nicotiana; Nicotine; Nitrosamines; Oxidoreductases, N-Demethylating; Plant Leaves; Plant Proteins; RNA Interference | 2016 |
Combination of Plant Metabolic Modules Yields Synthetic Synergies.
Topics: Alkaloids; Cell Line; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Cytochrome P-450 Enzyme System; Genes, Reporter; Microscopy, Fluorescence; Nicotiana; Nicotine; Phenotype; Plant Cells; Plant Proteins; Plants, Genetically Modified; Signal Transduction | 2017 |
Detoxification and elimination of nicotine by nectar-feeding birds.
Topics: Animal Nutritional Physiological Phenomena; Animals; Cotinine; Dehydration; Eating; Inactivation, Metabolic; Nicotine; Osmoregulation; Passeriformes; Plant Nectar; Species Specificity | 2017 |
Enantioseparation of nornicotine in tobacco by ultraperformance convergence chromatography with tandem mass spectrometry.
Topics: Chromatography; Nicotiana; Nicotine; Stereoisomerism; Tandem Mass Spectrometry | 2017 |
Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes.
Topics: Aged; Aged, 80 and over; Brain; Cytochrome P-450 CYP2B6; Female; Humans; Ketamine; Male; Methadone; Microsomes; Middle Aged; Nicotine; Oxidation-Reduction; Polymorphism, Single Nucleotide; Recombinant Proteins; Stereoisomerism; Tobacco Use Disorder | 2019 |
Mode-of-action analysis of the effects induced by nicotine in the in vitro micronucleus assay.
Topics: Aneugens; Animals; Cell Line; Cell Nucleus; CHO Cells; Cricetulus; DNA; DNA Damage; Micronucleus Tests; Microtubules; Mutagenicity Tests; Mutagens; Nicotine; Phosphorylation; Tubulin | 2019 |
Chemical Responses of Nicotiana tabacum (Solanaceae) Induced by Vibrational Signals of a Generalist Herbivore.
Topics: Alkaloids; Anabasine; Animals; Gas Chromatography-Mass Spectrometry; Herbivory; Host-Parasite Interactions; Larva; Lepidoptera; Linear Models; Nicotiana; Nicotine; Principal Component Analysis; Pyridines; Vibration | 2019 |
Increased Leaf Nicotine Content by Targeting Transcription Factor Gene Expression in Commercial Flue-Cured Tobacco (
Topics: Acetates; Alkaloids; Anabasine; Cyclopentanes; Ethylenes; Gene Expression Regulation, Plant; Helix-Loop-Helix Motifs; Nicotiana; Nicotine; Oxylipins; Plant Growth Regulators; Plant Leaves; Plants, Genetically Modified; Promoter Regions, Genetic; Pyridines; Tobacco Products; Transcription Factors | 2019 |
Development of a nornicotine-reduced flue-cured tobacco line via EMS mutagenesis of nicotine N-demethylase genes.
Topics: Cytochrome P-450 Enzyme System; Ethyl Methanesulfonate; Nicotiana; Nicotine; Nitrosamines; Plant Leaves; Plant Proteins; RNA Interference | 2020 |
Effects of nicotine, nornicotine and cotinine, alone or in combination, on locomotor activity and ultrasonic vocalization emission in adult rats.
Topics: Animals; Central Nervous System Stimulants; Cotinine; Locomotion; Male; Nicotine; Rats; Rats, Long-Evans; Ultrasonic Waves; Vocalization, Animal | 2020 |
Biocompatible SPME fibers for direct monitoring of nicotine and its metabolites at ultra trace concentration in rabbit plasma following the application of smoking cessation formulations.
Topics: Anabasine; Animals; Chromatography, High Pressure Liquid; Cotinine; Isotope Labeling; Limit of Detection; Nicotine; Rabbits; Reference Standards; Reproducibility of Results; Smoking Cessation; Solid Phase Microextraction; Tandem Mass Spectrometry; Time Factors | 2020 |
Chiral determination of nornicotine, anatabine and anabasine in tobacco by achiral gas chromatography with (1S)-(-)-camphanic chloride derivatization: Application to enantiomeric profiling of cultivars and curing processes.
Topics: Alkaloids; Anabasine; Bridged-Ring Compounds; Chlorides; Chromatography, Gas; Lactones; Nicotiana; Nicotine; Pyridines; Stereoisomerism | 2020 |
Identification and characterization of Nornicotine degrading strain Arthrobacter sp. NOR5.
Topics: Arthrobacter; Biotransformation; Humans; Nicotiana; Nicotine | 2021 |
Analysis of Nicotine and Non-nicotine Tobacco Constituents in Aqueous Smoke/Aerosol Extracts by UHPLC and Ultraperformance Convergence Chromatography-Tandem Mass Spectrometry.
Topics: Chromatography, High Pressure Liquid; Electronic Nicotine Delivery Systems; Molecular Structure; Nicotiana; Nicotine; Tandem Mass Spectrometry; Tobacco Products; Tobacco, Waterpipe; Water | 2020 |
A Simple and High-Throughput LC-MS-MS Method for Simultaneous Measurement of Nicotine, Cotinine, 3-OH Cotinine, Nornicotine and Anabasine in Urine and Its Application in the General Korean Population.
Topics: Anabasine; Chromatography, Liquid; Cotinine; Humans; Nicotine; Republic of Korea; Tandem Mass Spectrometry | 2022 |
Metal-Mediated Organocatalysis in Water: Serendipitous Discovery of Aldol Reaction Catalyzed by the [Ru(bpy)
Topics: Aldehydes; Catalysis; Metals; Nicotine; Water | 2022 |
Structure Elucidation and Quantitation of 11 N'-n-Acylnornicotines in Cherry-Red Tobacco.
Topics: Chromatography; Mass Spectrometry; Nicotiana; Nicotine | 2023 |
Characterization of a novel nornicotine-degrading strain Mycolicibacterium sp. SMGY-1XX from a nornicotine-degrading consortium and preliminary elucidation of its biodegradation pathway by multi-omics analysis.
Topics: Alkaloids; Biodegradation, Environmental; Multiomics; Nicotiana; Nicotine; Phylogeny; Proteomics | 2023 |