nicotine has been researched along with methoxsalen in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Scott, EE; Stephens, ES; Walsh, AA | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Kaplan, HL; Sellers, EM; Tyndale, RF | 1 |
| Kilicarslan, T; Sellers, EM; Tyndale, RF; Zhang, W | 1 |
| Fernandes, LC; Sellers, EM; Tyndale, RF | 1 |
| Djordjevic, MV; Ramamoorthy, Y; Sellers, EM; Tyndale, RF; Zeman, MV | 1 |
| Damaj, MI; Martin, BR; Sellers, EM; Siu, EC; Tyndale, RF | 1 |
| Miksys, S; Tyndale, RF | 1 |
| Khokhar, JY; Tyndale, RF | 1 |
| Lu, H; Wang, SL; Wang, X; Wang, Y; Yang, X; Zhang, X; Zhang, Z | 1 |
| Alsharari, SD; Damaj, MI; Siu, EC; Tyndale, RF | 1 |
| Bagdas, D; Damaj, MI; Muldoon, PP; Tyndale, RF; Zhu, AZ | 1 |
| Biala, G; Budzynska, B; Kruk-Slomka, M; Skalicka-Wozniak, K; Wydrzynska-Kuzma, M | 1 |
2 review(s) available for nicotine and methoxsalen
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
Decreasing smoking behaviour and risk through CYP2A6 inhibition.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Humans; Methoxsalen; Mixed Function Oxygenases; Nicotine; Polymorphism, Genetic; Prevalence; Tobacco Use Disorder | 2003 |
2 trial(s) available for nicotine and methoxsalen
| Article | Year |
|---|---|
Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking.
Topics: Administration, Oral; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Biological Availability; Breath Tests; Carbon Monoxide; Cross-Over Studies; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Double-Blind Method; Humans; Methoxsalen; Mixed Function Oxygenases; Nicotine; Nicotinic Agonists; Single-Blind Method; Smoking | 2000 |
The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo.
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 CYP2A6; Female; Ganglionic Stimulants; Humans; Injections, Subcutaneous; Male; Methoxsalen; Mixed Function Oxygenases; Nicotine; Nitrosamines; Placebos; Smoking | 2003 |
12 other study(ies) available for nicotine and methoxsalen
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.
Topics: Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Catalysis; Coumarins; Cytochrome P-450 CYP2A6; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxylation; Ligands; Models, Biological; Molecular Structure; Monoterpenes; Nitrophenols; Protein Binding; Recombinant Proteins; Substrate Specificity; Tranylcypromine | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro.
Topics: Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cotinine; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Methoxsalen; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Tranylcypromine; Tryptamines | 2001 |
Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Enzyme Inhibitors; Male; Methoxsalen; Mice; Mice, Inbred ICR; Microsomes; Mixed Function Oxygenases; Nicotine; Oxidation-Reduction | 2007 |
Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition.
Topics: Animals; Brain; Cell Membrane; Cytochrome P-450 CYP2B1; Enzyme Induction; Enzyme Inhibitors; Frontal Lobe; Immunoprecipitation; Isotope Labeling; Methoxsalen; Microsomes, Liver; Nicotine; Rats; Rats, Wistar; Tritium | 2009 |
Drug metabolism within the brain changes drug response: selective manipulation of brain CYP2B alters propofol effects.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Brain; Chlorisondamine; Cytochrome P-450 CYP2B1; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Inactivation, Metabolic; Injections, Intraventricular; Male; Methoxsalen; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Propofol; Rats; Rats, Wistar; Sleep; Time Factors; Tritium | 2011 |
Cytochrome P450 2A13 enhances the sensitivity of human bronchial epithelial cells to aflatoxin B1-induced DNA damage.
Topics: Aflatoxin B1; Aryl Hydrocarbon Hydroxylases; Bronchi; Cell Cycle; Cell Line; DNA Adducts; DNA Damage; Epithelial Cells; Humans; Immunoblotting; Methoxsalen; Microscopy, Confocal; Nicotine | 2013 |
Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cotinine; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Drug Interactions; Injections, Intraperitoneal; Male; Methoxsalen; Mice; Nicotine; Tandem Mass Spectrometry | 2014 |
Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
Topics: Animals; Anxiety; Aryl Hydrocarbon Hydroxylases; Conditioning, Psychological; Cytochrome P450 Family 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Male; Mecamylamine; Methoxsalen; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reward; Severity of Illness Index; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2014 |
In vivo modulation of the behavioral effects of nicotine by the coumarins xanthotoxin, bergapten, and umbelliferone.
Topics: 5-Methoxypsoralen; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Coumarins; Cytochrome P-450 CYP2A6; Depression; Locomotion; Male; Memory; Methoxsalen; Mice; Nicotine; Nicotinic Agonists; Nootropic Agents; Swimming; Umbelliferones | 2016 |