nicotine has been researched along with mecamylamine in 894 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 199 (22.26) | 18.7374 |
| 1990's | 222 (24.83) | 18.2507 |
| 2000's | 273 (30.54) | 29.6817 |
| 2010's | 170 (19.02) | 24.3611 |
| 2020's | 30 (3.36) | 2.80 |
| Authors | Studies |
|---|---|
| Hernandez, J; Hook, R; Martin, WR; Sloan, JW | 1 |
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Liljefors, T | 1 |
| Clementi, F; Dallanoce, C; De Amici, M; Fiorentini, C; Fucile, S; Gotti, C; Grazioso, G; Matera, C; Missale, C; Pucci, L; Zoli, M | 1 |
| Alderdice, MT; Weiss, GB | 1 |
| Ivankovich, AD; Klowden, AJ; Miletich, DJ | 1 |
| Ibi, A; Matsumoto, S; Nagao, T; Nakajima, T | 1 |
| Hanson, HM; Ivester, CA; Morton, BR | 1 |
| Rodgers, RJ | 1 |
| Gala, RR; Lawson, DM | 1 |
| Morgan, WW; Pfeil, KA | 1 |
| Everitt, BJ; Fuxe, K; Hökfelt, T | 2 |
| Mason, ST | 1 |
| Delashaw, JB; Dement, WC; Foutz, AS; Guilleminault, C | 1 |
| Hayashi, E; Mori, M; Yamada, S | 1 |
| Greene, LA; Rein, G | 1 |
| Mansner, R; Mattila, MJ | 2 |
| Chance, WT; Kallman, MD; Rosecrans, JA; Spencer, RM | 1 |
| Marotta, SF; Sithichoke, N | 1 |
| Agnati, L; Eneroth, P; Fuxe, K; Gustafsson, JA; Hökfelt, T; Löfström, A; Skett, B; Skett, P | 1 |
| Mansner, R | 1 |
| Cook, PG; Schechter, MD | 1 |
| Ahtee, L | 1 |
| Chance, WT; Rosecrans, JA; Schechter, MD | 1 |
| Haefely, W; Jalfre, M; Ruch-Monachon, MA | 1 |
| Bättig, K; Münster, G | 1 |
| Decima, EE; Engelhardt, JK | 1 |
| Barry, H; Hanin, I; Khachaturian, ZS; Shih, TM | 1 |
| Driscoll, P | 1 |
| Hamann, SR; Martin, WR | 1 |
| Blank, E; Dodds, WJ; Greenwood, B | 1 |
| Flores, CM; Hornby, PJ; Hulihan-Giblin, BA; Kellar, KJ; Lumpkin, MD | 1 |
| Arilla, E; Barrios, V; González-Parra, S | 1 |
| Goshima, Y; Misu, Y; Miyamae, T; Nakamura, S; Yue, JL | 2 |
| Abate, KL; Andresen, MJ; Hentall, ID; Wojcik, RS | 1 |
| Baker, M; Endoh, K; Kao, J; Leung, FW | 1 |
| Kita, T; Nakashima, T; Okamoto, M | 2 |
| Grenhoff, J; Svensson, TH | 1 |
| Bourlaud, I; Patte, F; Perault, MC; Underner, M | 1 |
| Blomqvist, O; Engel, JA; Söderpalm, B | 1 |
| Huston-Lyons, D; Kornetsky, C | 1 |
| Albuquerque, EX; Garcha, HS; Stolerman, IP | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Ferraro, L; Morari, M; Nordberg, A; Spalluto, P; Tanganelli, S | 1 |
| Iwamoto, ET | 2 |
| Allen, Y; Arendt, T; Gray, JA; Hodges, H; Lantos, PL; Mitchell, SN; Sinden, J | 1 |
| Joseph, MH; Mitchell, SN; Smith, KM | 1 |
| Brazell, MP; Gray, JA; Mitchell, SN | 1 |
| Adams, DJ; Fieber, LA | 1 |
| Ando, K; Miyata, H; Yanagita, T | 1 |
| Evans, RG; Ludbrook, J | 1 |
| Buccafusco, JJ; Elrod, K | 1 |
| Fang, LB; Lee, LY; Morton, RF; Wang, AL | 1 |
| Levin, ED; Rose, JE | 2 |
| Arilla, E; Barrios, V; Colas, B; Rodriguez-Sanchez, MN | 1 |
| Fung, YK | 1 |
| Arilla, E; Barrios, V; Rodríguez-Sánchez, MN | 1 |
| Cox, BM; Izenwasser, S; Jacocks, HM; Rosenberger, JG | 1 |
| George, C; Martin, BR; Martin, TJ; May, EL; Suchocki, JA | 1 |
| Gallagher, JP; Wong, LA | 1 |
| Goshima, Y; Kubo, T; Misu, Y; Nakamura, S | 1 |
| Cooley, JE; Fowler, SC; Lombardo, TW; Moss, RA; Sult, S; Villarosa, GA | 1 |
| Matta, SG; McAllen, KM; Sharp, BM | 1 |
| Christensen, MK; Smith, DF | 1 |
| Abood, LG; Banerjee, S; Kreilick, K; Punzi, JS | 1 |
| Brazell, MP; Gray, JA; Joseph, MH; Mitchell, SN | 1 |
| Hulihan-Giblin, BA; Kellar, KJ; Lumpkin, MD | 1 |
| Campbell, ED; Carter, WH; Gennings, C; Martin, BR; Martin, TJ; Staniswalis, JG; White, KL | 1 |
| Archer, T; Gillberg, PG; Gordh, T; Hartvig, P; Jansson, I; Post, C; Sottile, A | 1 |
| Reavill, C; Stolerman, IP | 1 |
| Collins, AC; Freund, RK; Jungschaffer, DA | 1 |
| Chen, YM; Dixon, WR | 1 |
| Martin, BR; Martin, TJ; May, EL; Suchocki, J | 2 |
| Fellhauer, M | 1 |
| Markus, JK; Mylecharane, EJ; Phillips, CA; Shaw, J | 2 |
| Del Rio, J; Molinero, MT | 1 |
| Lajtha, A; Lapin, E; Leeman, S; Maker, H; Naftchi, NE; Sleis, J | 1 |
| Amano, H; Kubo, T; Kurahashi, K; Misu, Y | 1 |
| Alavijeh, MS; Brazell, MP; Gray, JA; Joseph, MH; Mitchell, SN | 1 |
| Bodoff, M; Brenner, T; Saphier, D; Weidenfeld, J | 1 |
| Johnson, KM; Snell, LD | 1 |
| Bostwick, M; Martin, WR; Sloan, JW | 1 |
| Araki, Y; Furuno, K; Gomita, Y; Suemaru, K | 1 |
| Flores, CM; Hulihan-Giblin, BA; Kellar, KJ | 1 |
| Coen, KM; Corrigall, WA | 1 |
| Martin, BR; Martin, TJ; Onaivi, ES | 1 |
| de la Garza, R; Freedman, R; Hoffer, J | 1 |
| Antoni, G; Hartvig, P; Långström, B; Lundqvist, H; Nordberg, A; Ulin, J | 1 |
| Henningfield, JE; Levin, ED; Rose, JE; Sampson, A | 1 |
| Goldstein, BD; Ibrahim, NA | 1 |
| Coen, KM; Corrigall, WA; Herling, S | 1 |
| Fudala, PJ; Iwamoto, ET; Teoh, KW | 1 |
| Gold, WM; Hartiala, JJ; Mapp, C; Mitchell, RA | 1 |
| Hassoni, AA; Kerkut, GA; Walker, RJ | 1 |
| Hayashi, E; Kagawa, Y; Kosuge, T; Takayanagi, N; Tsuji, K; Yamada, S | 1 |
| Agnati, LF; Andersson, K; Fuxe, K; Härfstrand, A | 1 |
| Freeman, GB; Gibson, GE; Sherman, KA | 1 |
| Buccafusco, JJ; Elrod, K; Jackson, WJ | 1 |
| Hernandez, L; Hoebel, BG; Mifsud, JC | 1 |
| Grabowski, J; Hall, SM | 1 |
| Emmett-Oglesby, MW; Harris, CM; Lal, H; Robinson, NG | 1 |
| Majchrzak, MJ; Pomerleau, CS; Pomerleau, OF | 1 |
| Norris, EA; Rauch, RJ; Stolerman, IP | 1 |
| Aceto, MD; Ferguson, GS; Hinson, JR; Tucker, SM | 1 |
| Craft, RM; Howard, JL | 1 |
| Henningfield, JE; Herning, RI; Pickworth, WB | 1 |
| Ahtee, L; Haikala, H | 1 |
| Della Briotta, G; Heuss, L; Hösli, E; Hösli, L; Quadri, L | 1 |
| Becker, KL; Linnoila, RI; Nylén, ES | 1 |
| Daw, NW; Kratz, KE; Parkinson, D | 1 |
| Collins, AC; Freund, RK; Jungschaffer, DA; Martin, BJ; Ullman, EA | 1 |
| Opitz, K; Weischer, ML | 1 |
| Alaranta, S; Klinge, E; Sjöstrand, NO | 1 |
| Dam, M; Fanelli, RJ; London, ED | 1 |
| Asahina, M; Kita, T; Kurogochi, Y; Nakashima, T; Shirase, M | 1 |
| Robinson, SE | 1 |
| Stolerman, IP | 1 |
| Fuller, CA; Miller, JD; Murakami, DM | 1 |
| Alvarado-Garcia, R; Lee, MA; Witkin, JM; Witkin, KM | 1 |
| Geertsen, S; Quik, M; Trifaró, JM | 1 |
| Banay-Schwartz, M; Debler, EA; Dunlop, DS; Reith, ME; Sershen, H | 1 |
| Clemens, LG; Weaver, DR | 1 |
| Blozovski, D; Duméry, V | 1 |
| Boi, V; Gessa, GL; Mereu, G; Naes, L; Westfall, TC; Yoon, KW | 1 |
| Forster, MJ; Lal, H; Retz, KC; Trimmer, CK | 1 |
| Collins, AC; Evans, CB; Marks, MJ; Miner, LL | 1 |
| Jarvis, MJ; West, RJ | 1 |
| Aston-Jones, G; Grenhoff, J; Svensson, TH | 1 |
| Lahiri, S; Mulligan, E | 1 |
| Aceto, MD; Awaya, H; Egle, JL; Kachur, JF; Martin, BR; May, EL | 1 |
| Alderete, BE; Modak, AT | 2 |
| Ganguzza, CC; White, JM | 1 |
| Kellar, KJ; Schwartz, RD | 1 |
| Ryan, LJ | 1 |
| Clarke, PB; Hommer, DW; Pert, A; Skirboll, LR | 1 |
| Andersson, K | 1 |
| Demaree, GE; McLeod, DG; Reynolds, DG | 2 |
| Turner, N; Weetman, DF | 1 |
| Alkadhi, KA; McIsaac, RJ | 1 |
| Gulati, OD; Sethi, OP | 1 |
| Bianchi, C; Tomasi, L | 1 |
| Flacke, W; Gillis, RA | 2 |
| Alper, MH; Flacke, W; Garfield, JM; Gillis, RA | 1 |
| Gascon, AL; Walaszek, EJ | 1 |
| Bevan, JA; Nedergaard, OA | 1 |
| Watson, PJ | 2 |
| Blanton, RJ; Komiskey, HL; Rudy, TA | 1 |
| Lederis, K; Medaković, M | 1 |
| Ulrich, K | 1 |
| Tang, AH; Yim, GK | 1 |
| Akubue, PI | 1 |
| Gokhale, SD; Gulati, OD; Panchal, DI | 1 |
| Funasaka, T | 1 |
| Aceto, MD; Bentley, HC; Dembinski, JR | 1 |
| Natoff, IL | 1 |
| Goodyear, JM; Morrison, CF; Sellers, CM | 1 |
| McQueen, DS | 1 |
| Nose, T; Takemoto, H | 1 |
| Alhava, E; Klinge, E; Mansner, R | 1 |
| Hirschhorn, ID; Rosecrans, JA | 1 |
| Fink, R; Goldfarb, T; Jarvik, ME; Stolerman, IP | 1 |
| Baird, J; Lang, WJ | 1 |
| Lang, WJ; Rush, ML | 1 |
| Ginzel, KH | 1 |
| Thörner, R; Zetler, G | 1 |
| Bite, A; Dóda, M; György, L; Phan, DV | 1 |
| Grossman, SP; Ross, JF | 1 |
| Overstreet, DH | 1 |
| Brase, DA; Loh, HH; Tseng, LF; Way, EL | 1 |
| Bowling, C; Pradhan, SN | 1 |
| Glick, SD; Jarvik, ME; Zimmerberg, B | 1 |
| Rosecrans, JA; Schechter, MD | 2 |
| Hall, GH | 2 |
| Newman, LM | 1 |
| Domino, EF; Olds, ME | 2 |
| Morrison, CF; Stephenson, JA | 1 |
| Eldred, E; Ginzel, KH; Sasaki, Y | 1 |
| Domino, EF; Morrison, J; Stitzer, M | 1 |
| Eldred, E; Ginzel, KH; Watanabe, S | 1 |
| Bhagat, B; Kramer, SZ; Seifter, J | 1 |
| Mattila, MJ; Saarnivaara, L | 1 |
| Kayaalp, SO; McIsaac, RJ | 1 |
| van Riezen, H | 1 |
| Nikki, P | 1 |
| McCance, I; Phillis, JW | 2 |
| Concha, G; González, E; Novakovic, L; Penna, M | 1 |
| Krip, G; Pinsky, C; Vazquez, AJ | 1 |
| Domino, EF; Yamamoto, KI | 2 |
| Barnett, A; Benforado, JM | 1 |
| Oliverio, A | 1 |
| Armitage, AK; Milton, AS; Morrison, CF | 1 |
| Botting, JH; Turmer, AD | 1 |
| McCulloch, MW; Rand, MJ; Sarantos-Laska, C | 1 |
| Clarke, PB; Kumar, R | 3 |
| Kumar, R; Pratt, JA; Stolerman, IP | 1 |
| Gibson, GE; Pelmas, CJ; Peterson, C | 1 |
| Garcha, HS; Giardini, V; Kumar, R; Pratt, JA; Stolerman, IP | 1 |
| Agnati, LF; Anderson, K; Eneroth, P; Fuxe, K | 1 |
| Horstmann, M | 1 |
| Betti, R; Casanueva, FF; Cella, SG; Mantegazza, P; Müller, EE | 1 |
| Martin, WR; Wu, KM | 1 |
| Henningfield, JE | 1 |
| Henninfield, JE; Jasinski, DR; Johnson, RE; Miyasato, K | 1 |
| Rawson, RA; Tarver, AL; Tennant, FS | 1 |
| Garcha, HS; Kumar, R; Pratt, JA; Stolerman, IP | 1 |
| Tarver, AL; Tennant, FS | 1 |
| Iwamoto, ET; Williamson, EC | 1 |
| Bradley, PB; Lucy, AP | 1 |
| Goldberg, SR; Henningfield, JE; Risner, ME; Spealman, RD | 1 |
| Spealman, RD | 1 |
| Ceña, V; García, AG; Montiel, C; Sánchez-García, P | 1 |
| Chaturvedi, AK | 1 |
| Aceto, MD; Harris, LS; Meltzer, LT; Rosecrans, JA | 1 |
| Carron, L; DeNoble, VJ; Dragan, VP | 1 |
| Agnati, LF; Andersson, K; Eneroth, P; Fuxe, K | 1 |
| Goldberg, SR; Risner, ME | 1 |
| Goldberg, SR; Spealman, RD | 3 |
| Nordberg, A; Sundwall, A | 1 |
| Agnati, LF; Andersson, K; Eneroth, P; Fuxe, K; Gustafsson, JA | 1 |
| Kritzer, MF; Schwab, LS | 1 |
| Barchas, JD; Lorenz, RG; McIntire, SL; Roth, KA | 1 |
| Waldbillig, RJ | 1 |
| Gardner, ML; Goldberg, SR; Spealman, RD | 1 |
| Hachisu, M; Kamimura, T; Maruyama, I; Ohata, H; Yamada, S | 1 |
| Imura, H; Kato, Y; Yoshida, K | 1 |
| Pickworth, WB; Sharpe, LG | 1 |
| Arneric, SP; Brioni, JD; Brodie, MS; Decker, MW; Kim, DJ | 1 |
| Nisell, M; Nomikos, GG; Svensson, TH | 2 |
| Brough, PA; Gallagher, T; Livett, BG; Molloy, L; Wonnacott, S | 1 |
| Andersson, K; Arner, P | 1 |
| Garcha, HS; Mirza, NR; Stolerman, IP | 1 |
| Heller, HC; Miller, JD; Trachsel, L | 1 |
| Abood, LG; Kende, AS; Lerner-Marmarosh, N; Wang, DX | 1 |
| Behm, FM; Lane, JD; Levin, ED; Ripka, GV; Rose, JE; Stein, RM; Westman, EC | 1 |
| Holley, LA; Sarter, M; Turchi, J | 1 |
| Damaj, MI; Martin, BR; Welch, SP | 3 |
| O'Shea, SM; Ochoa, EL | 1 |
| Basbaum, AI; Benowitz, NL; Dallman, MF; Heller, PH; Jänig, W; Levine, JD; Miao, FJ | 1 |
| Auman, JT; Briggs, SJ; Christopher, NC; Levin, ED | 1 |
| Abood, LG; Carroll, FI; Lerner-Marmarosh, N | 1 |
| Ferger, B; Kuschinsky, K | 1 |
| Arezo, S; James, JR; Johnson, JH; Rosecrans, JA; Villanueva, HF | 1 |
| Fernández, AG; Gristwood, RW; O'Neill, MF; Palacios, JM | 1 |
| Brioni, JD; O'Neill, AB | 1 |
| Carter, VA; Conrad, DL; Cunningham, JS; Hebert, KM; Lake, JR; Malin, DH; Wilson, OB | 1 |
| Hiramatsu, M; Kameyama, T; Nabeshima, T; Satoh, H | 1 |
| Balfour, DJ; Benwell, ME; Birrell, CE | 1 |
| Hasegawa, T; Itoh, A; Katono, Y; Nabeshima, T; Nitta, A | 1 |
| Curzon, P; Decker, MW; Kim, DJ | 1 |
| Dhatt, RK; Gudehithlu, KP; Hadjiconstantinou, M; Neff, NH; Tejwani, GA; Wemlinger, TA | 1 |
| Changeux, JP; Vidal, C | 1 |
| Eyl, C; Hakan, RL; Hart, C | 1 |
| Jayaraman, A; Kiba, H | 1 |
| Shoaib, M; Stolerman, IP | 1 |
| Khan, IM; Printz, MP; Taylor, P; Yaksh, TL | 1 |
| Collins, AC; Luo, Y; Marks, MJ; Selvaag, S | 1 |
| Arneric, SP; Brioni, JD; Buckley, MJ; Decker, MW; Kim, DJ; O'Neill, AB | 1 |
| Gomita, Y; Oishi, R; Suemaru, K | 1 |
| Clarke, PB; el-Bizri, H | 1 |
| Behm, FM; Levin, ED; Ripka, GV; Rose, JE; Stein, RM; Westman, EC | 1 |
| Khan, IM; Taylor, P; Yaksh, TL | 1 |
| Engberg, G; Hajos, M | 1 |
| Biftu, T; Eckman, J; Ip, S; Li, T; Libertine-Garahan, L; Qian, C; Shen, TY | 1 |
| Decker, MW; Majchrzak, MJ | 1 |
| Baldauf, J; Jurna, I; Krauss, P | 1 |
| Cattaneo, MG; Clementi, F; Codignola, A; Sher, E; Vicentini, LM | 1 |
| Loiacono, R; Mitchelson, F; Stephenson, J; Stevenson, J | 1 |
| Battaglia, C; Bobrie, G; Loufrani, E; Ménard, J | 1 |
| Ando, K; Hironaka, N; Miyata, H; Tsuda, T; Yanagita, T | 1 |
| Bettiker, RL; Bogdanov, M; Ribeiro, EB; Wurtman, RJ | 1 |
| Riekkinen, M; Riekkinen, P; Sirviö, J | 3 |
| Radek, RJ | 1 |
| Foster, CA; Matta, SG; Sharp, BM | 1 |
| Jayaraman, A; Kiba, H; Pang, Y | 1 |
| Mitchell, SN | 1 |
| Clement, JG | 1 |
| Hart, C; Ksir, C | 1 |
| Kinney, GG | 1 |
| Cossu, G; Fratta, W; Gessa, GL; Kuzmin, A; Martellotta, MC; Zvartau, E | 1 |
| Abdulla, FA; Bradbury, E; Calaminici, MR; Gray, JA; Lippiello, PM; Sinden, JD; Wonnacott, S | 1 |
| Gollapudi, L; Hentall, ID | 1 |
| Buccafusco, JJ; Decker, MW; Evans-Martin, FF; Jackson, WJ; Terry, AV; Zagrodnik, S | 1 |
| Levin, ED; Torry, D | 1 |
| Caggiula, AR; Epstein, LH; Perkins, KA; Saylor, S | 1 |
| Dahl, MV; Grando, SA; Horton, RM; Kist, DA; Lee, TX; Mauro, TM | 1 |
| Collins, AC; Marks, MJ; Pauly, JR; Robinson, SF; van de Kamp, JL | 1 |
| Brioni, JD; Kim, DJ; O'Neill, AB | 1 |
| Kim, JS; Levin, ED | 1 |
| Marchi, M; Raiteri, M | 1 |
| Farzin, D; Zarrindast, MR | 1 |
| Goshima, Y; Kosaka, K; Miki, K; Misu, Y; Miyamae, T; Nakamura, S | 1 |
| Chergui, K; Nisell, M; Nomikos, GG; Panagis, G; Svensson, TH | 1 |
| Toth, E | 1 |
| Hutson, P; Sullivan, JP; Wilkie, GI; Wonnacott, S | 1 |
| Nordberg, A; Svensson, AL | 2 |
| Chambers, RA; Levin, ED; McEvoy, JP; Moore, J | 1 |
| Bordey, A; Feltz, P; Trouslard, J | 1 |
| Ise, Y; Maeda, J; Misawa, M; Suzuki, T; Tsuda, M | 1 |
| Glick, SD; Maisonneuve, IM; Visker, KE | 1 |
| Marshall, D; Redfern, P; Soliakov, L; Wonnacott, S | 1 |
| Buckler, KJ; Dasso, LL; Vaughan-Jones, RD | 1 |
| Mariathasan, EA; Stolerman, IP; White, JA | 1 |
| Mucha, RF | 1 |
| Freund, RK; Palmer, MR | 1 |
| Oveisi, MR; Zarrindast, MR | 1 |
| Crooks, PA; Dwoskin, LP; Sonsalla, PK; Teng, L | 1 |
| Baranyi, M; Lajtha, A; Lendvai, B; Santha, E; Sershen, H; Vizi, ES | 1 |
| Imoto, M; Ohno, T; Saito, K; Tani, Y; Tsuneyoshi, A | 1 |
| Deibel, CR; Glick, SD; Maisonneuve, IM; Mann, GL | 1 |
| Marshall, DL; Redfern, PH; Wonnacott, S | 1 |
| Abood, LG; Journet, M; Kende, AS; Rubin, L; Sharma, VK; Sheu, SS; Wang, DX | 1 |
| Riekkinen, M; Riekkinen, P | 1 |
| Fu, Y; Matta, SG; Sharp, BM; Valentine, JD | 1 |
| Benowitz, NL; Heller, PH; Levine, JD; Miao, FJ | 1 |
| Goldberg, SR; Schindler, CW; Shoaib, M | 1 |
| Almaraz, L; Dinger, B; Fidone, S; Gómez-Niño, MA; González, C; Obeso, A | 1 |
| Gomita, Y; Kawasaki, H; Oishi, R; Suemaru, K; Tanizaki, Y | 1 |
| Briggs, SJ; Christopher, NC; Levin, ED | 1 |
| Cui, WY; Gao, ZG; Liu, CG | 1 |
| Christopher, NC; Einstein, G; Levin, ED; Schwartz-Bloom, RD; Torry, D; Yu, X | 1 |
| Baptista, M; Yeomans, J | 1 |
| Akaike, A; Kihara, T; Kimura, J; Kochiyama, H; Kume, T; Maeda, T; Sawada, H; Shimohama, S | 1 |
| Gomita, Y; Kawasaki, H; Suemaru, K | 1 |
| Haass, C; Jeong, SJ; Kim, SH; Kim, YH; Kim, YK; Suh, YH | 1 |
| Dawe, GS; Gray, JA; Hamid, S; Stephenson, JD | 1 |
| Amitai, Y; Connors, BW; Gil, Z | 1 |
| Ise, Y; Misawa, M; Mori, T; Suzuki, T | 1 |
| Buxton, ST; Crooks, PA; Dwoskin, LP; Teng, L | 1 |
| Lopez, I; McKay, DB | 1 |
| Fitzgerald, RS; Sham, JS; Shirahata, M | 1 |
| Gomita, Y; Kawasaki, H; Suemaru, K; Tanizaki, Y | 1 |
| Cattaneo, MG; D'atri, F; Vicentini, LM | 1 |
| Greenshaw, AJ; Ivanová, S | 1 |
| Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M | 1 |
| Nagai, N; Takada, A; Takada, Y; Takahashi, H; Urano, T | 2 |
| Akaike, N; Ishibashi, H; Murata, O; Nabekura, J | 1 |
| Chambers, EL; Ivonnet, PI | 1 |
| Hertel, P; Hildebrand, BE; Nomikos, GG; Schilström, B; Svensson, TH | 1 |
| Carstens, E; Dessirier, JM; O'Mahony, M; Sieffermann, JM | 1 |
| Mataki, C; Nankai, M; Semba, J; Toru, M; Yamada, S | 1 |
| Borycz, J; Bugajski, J; Gadek-Michalska, A; Głód, R | 1 |
| Adams, ML; Cicero, TJ | 1 |
| Bienkowski, P; Koros, E; Kostowski, W; Piasecki, J; Stefanski, R | 1 |
| Dannals, RF; Finley, PA; Mochizuki, T; Musachio, JL; Scheffel, U; Wagner, HN; Zhan, Y | 1 |
| Imoto, M; Ohno, T; Saito, K; Tani, Y | 1 |
| Dohi, S; Fujiwara, H; Iida, H; Iida, M; Takenaka, M | 1 |
| Behm, FM; Rose, JE; Westman, EC | 2 |
| George, TP; Roth, RH; Verrico, CD | 1 |
| Harr, A; Ilivitsky, V; Knott, VJ; Mahoney, C | 1 |
| Chappell, AM; Nadal, R; Samson, HH | 1 |
| Felipo, V; Grisolía, S; Llansola, M; Miñana, MD; Montoliu, C | 1 |
| Cooper, J; Keyser, K; Kuryatov, A; Lindstrom, J; Nelson, ME; Olale, F; Wang, F | 1 |
| Kavitharaj, NK; Vijayammal, PL | 1 |
| Boardman, A; Kaplan, S; Levin, ED | 1 |
| Drucker-Colín, R; Maza-Flores, A; Meade-Huerta, P; Mihailescu, S; Palomero-Rivero, M | 1 |
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| Kishimoto, K; Kitamura, Y; Minamino, H; Shibaike, T; Shimohama, S; Takata, K; Takeuchi, H; Taniguchi, T; Tsushima, J; Yanagida, T; Yasui, H | 1 |
| Oryan, S; Parivar, K; Solati, J; Zarrindast, MR | 1 |
| Breivik, T; Gjermo, P; Gundersen, Y; Opstad, PK; von Hörsten, S | 2 |
| Rose, JE | 1 |
| Hu, J; Jin, G; Liu, Q; Lucero, L; Lukas, RJ; Wu, J; Yang, K; Zhen, X; Zheng, C | 1 |
| Cho, GW; Kim, HY; Kim, SH; Kim, Y; Koh, SH; Noh, MY | 1 |
| Fu, XW; Lindstrom, J; Spindel, ER | 1 |
| Bishop, SF; Lauzon, NM; Laviolette, SR; Sun, N; Tan, H | 1 |
| Basselin, M; Chang, L; Chen, M; Greenstein, D; Nguyen, HN; Rapoport, SI | 1 |
| Bruijnzeel, AW; Isaac, SK; Marcinkiewcz, CA; Marshall, A; Prado, MM; Rylkova, D | 1 |
| Nakao, S; Ogata, Y; Sugiya, H | 1 |
| Desimone, JA; Lyall, V; Melone, P; Mummalaneni, S; Nicolelis, MA; Oliveira-Maia, AJ; Phan, TH; Simon, SA; Stapleton-Kotloski, JR | 1 |
| Bevins, RA; Murray, JE | 1 |
| Barrett, ST; Johnson, RN; Odum, AL; Ward, RD | 1 |
| Gandía, L; García, AG; García-Eguiagaray, J; Tapia, L | 1 |
| Harding, JW; Munn, C; Ross, RC; Wilson, WL; Wright, JW | 1 |
| Maldonado, R; Trigo, JM; Zimmer, A | 1 |
| Cain, ME; Coolon, RA | 1 |
| Harris, AC; Keyler, DE; LeSage, MG; Pentel, PR; Roiko, SA | 1 |
| Barros, DM; de Aguiar, RB; de Castro, MR; de Freitas, DP; dos Santos, LC; Dummer, NS; Geracitano, LA; Lima, JV; Marins, LF; Monserrat, JM; Valente, Rde S | 1 |
| Das, JR; Tizabi, Y | 1 |
| Crooks, PA; Dhawan, GK; Dwoskin, LP; Siripurapu, KB; Smith, AM; Zhang, Z | 1 |
| Kamei, C; Masuoka, T | 1 |
| Harris, LS; Kwilasz, AJ; Vann, RE | 1 |
| Hashim, A; Lajtha, A; Sershen, H | 1 |
| Engelmann, JM; Gewirtz, JC; Radke, AK | 1 |
| Bernabeu, RO; Pascual, MM; Pastor, V | 1 |
| Benoit, M; Damann, N; Everaerts, W; Gees, M; Janssens, A; Karashima, Y; Meseguer, VM; Nemery, B; Nilius, B; Talavera, K; Vanoirbeek, JA; Vennekens, R; Viana, F; Voets, T | 1 |
| Clarke, PB; Pierre, VJ; Sorge, RE | 1 |
| Caggiula, AR; Donny, EC; Levin, ME; Mays, KL; Palmatier, MI; Sved, AF | 1 |
| Natividad, LA; O'Dell, LE; Tejeda, HA; Torres, OV | 1 |
| Bevins, RA; Crooks, PA; Dwoskin, LP; Struthers, AM; Wilkinson, JL | 1 |
| Drott, JT; Hutson, PH; Sharik, SS; Sur, C; Theberge, CR; Uslaner, JM; Williams, DL; Zeng, Z | 1 |
| Bruijnzeel, AW; Davenport, JJ; Derendorf, H; Geier, JE; Gold, MS; Pauly, JR; Sabarinath, SN; Shah, HP; Small, E; Yamada, H; Yavarovich, KR | 1 |
| Baccus, S; Braddy, D; Cannady, R; Levin, ED; Morton, T; Rose, JE; Sanders, D; Simkiss, D; Weaver, N | 1 |
| Crooks, PA; Deaciuc, AG; Dwoskin, LP; Pivavarchyk, M; Subramanian, KL; Zhang, Z | 1 |
| Brundage, CM; Cartagena, CM; Potter, EA; Taylor, BE | 1 |
| Allison, C; Rushforth, SL; Shoaib, M; Wonnacott, S | 1 |
| Gilmour, G; Loomis, S | 1 |
| Bordia, T; Campos, C; McIntosh, JM; Quik, M | 1 |
| Biala, G; Budzynska, B; Staniak, N | 1 |
| Beigzadeh, R; Meshkani, J; Rezayof, A; Rostami, P; Zarrindast, MR | 1 |
| Bardo, MT; Neugebauer, NM; Stairs, DJ | 1 |
| Biala, G; Staniak, N | 1 |
| Hiroi, N; Scott, D | 1 |
| Dallery, J; Jones, J; Raiff, BR | 1 |
| Carloni, P; Cherubini, E; Giorgetti, A; Griguoli, M; Maul, A; Nguyen, C | 1 |
| Bevins, RA; Murray, JE; Polewan, RJ; Walker, AW | 1 |
| Cannas, M; Migliario, M; Renò, F; Rocchetti, V | 1 |
| George, TP; Sacco, KA; Wing, VC | 1 |
| Cunningham, CS; McMahon, LR | 2 |
| Gardner, PD; Grady, SR; Improgo, MR; Liu, L; Marks, MJ; McIntosh, JM; Meyers, EE; Soll, LG; Tapper, AR; Zhao-Shea, R | 1 |
| Dong, E; Guidotti, A; Kadriu, B; Maloku, E; Pibiri, F; Satta, R; Zhubi, A | 1 |
| Andrekanic, JD; Czambel, RK; Gentile, NE; Karwoski, TE; Rhodes, ME; Rubin, RT | 1 |
| Cahir, E; Drago, J; Lawrence, AJ; Pillidge, K | 1 |
| Brown, SJ; Doughty, AH; Fuchs, JR; Jackson, ER; Kirshenbaum, AP; Miltner, BC | 1 |
| Rehan, VK; Sakurai, R; Torday, JS | 1 |
| Harrison, AA; Kolokotroni, KZ; Rodgers, RJ | 1 |
| Fujita, T; Kumamoto, E; Liu, T | 1 |
| Feng, L; Gusev, AG; Kalappa, BI; Kem, WR; Uteshev, VV | 1 |
| Levin, ED | 1 |
| Brooks, EA; Jutkiewicz, EM; Kynaston, AD; Rice, KC; Woods, JH | 1 |
| Balerio, GN; Calvo, M; Moutinho, LM; Varani, AP | 1 |
| Liu, Q; Sun, J; Tan, X; Wu, L; Yi, K; Yu, M | 1 |
| Chakrabarti, A; Hota, D; Sahai, AK; Sood, N | 1 |
| Czoty, PW; Gould, RW; Nader, MA; Nader, SH | 1 |
| Glick, SD; Maisonneuve, IM; McCallum, SE; Sell, EM | 1 |
| Nasehi, M; Sharifi, S; Zarrindast, MR | 1 |
| Bucci, DJ; Newhouse, PA; Potter, AS | 1 |
| Friehs, G; Ginzkey, C; Hackenberg, S; Hagen, R; Kleinsasser, NH; Koehler, C; Richter, E; Stueber, T | 1 |
| Markou, A; Olivier, B; Stoker, AK | 2 |
| Duchemin, AM; Hadjiconstantinou, M; McCarthy, MJ; Neff, NH | 1 |
| Gengin, MT; Lobzina, ES; Pavlova, OV; Solov'ev, VB; Solov'eva, OV | 1 |
| Arora, S; Rehni, AK; Singh, TG | 2 |
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| Alexander, JC; Bishnoi, M; Bruijnzeel, AW; Ford, J; Ji, Y; Rogers, JA; Scheick, S | 1 |
| Aggen, SH; Anton, R; Brunzell, DH; Chen, J; Chen, X; Damaj, I; Farrer, LA; Gejman, P; Gelernter, J; Holmans, P; Jackson, K; Kendler, KS; Kranzler, HR; Kuo, PH; Levinson, DF; Li, MD; Ma, JZ; Payne, TJ; Sherva, R; van der Vaart, A; Webb, BT | 1 |
| Caggiula, AR; Coddington, S; Donny, EC; Sheppard, J; Sved, AF; Sweitzer, M; Verdecchia, N; Weaver, MT | 1 |
| Grady, SR; Marks, MJ; O'Neill, HC; Ortiz, NC | 1 |
| Guo, L; Li, L; Pan, Z; Wang, W; Wu, Z; Zhou, Q | 1 |
| Balfour, DJ; Breen, KC; Scerri, C; Stewart, CA | 1 |
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| Hayashi, M; Kawano, H; Kimura-Kuroda, J; Komuta, Y; Kuroda, Y | 1 |
| Huestis, MA; Scheidweiler, KB; Shakleya, DM | 1 |
| Cunningham, CS; Javors, MA; McMahon, LR | 1 |
| Caviedes, P; Cuevas, C; Huenchuguala, S; Muñoz, P; Paris, I; Segura-Aguilar, J; Tizabi, Y; Villa, M | 1 |
| Carpenter, LL; Philip, NS; Price, LH; Tyrka, AR | 1 |
| Czambel, RK; Karwoski, TE; Rhodes, ME; Rubin, RT; Skwara, AJ | 1 |
| Ameno, K; Jamal, M; Kinoshita, H; Miki, T; Nakamura, Y; Ono, J; Sultana, R; Tanaka, N | 1 |
| Sanberg, PR; Shytle, RD; Vindrola-Padros, C | 1 |
| Blendy, JA; Hilario, MR; Turner, JR | 1 |
| Harris, AC; Manbeck, KE; Schmidt, CE; Shelley, D | 1 |
| Fletcher, PJ; Guy, EG | 1 |
| Buczynski, MW; Natividad, LA; O'Dell, LE; Parsons, LH; Torres, OV | 1 |
| Fujikawa, K; Fukumori, R; Kim, YH; Kitajima, S; Kou, M; Le, NQ; Nakamichi, N; Nakazato, R; Takarada, T; Yoneda, Y | 1 |
| Alijanpour, S; Assadpour, S; Rezayof, A | 1 |
| Dube, SL; Potter, AS; Ryan, KK | 1 |
| Biała, G; Budzyńska, B; Kruk-Słomka, M | 1 |
| Abdel, AY; Baynes, B; George, O; Gilpin, NW; Weil, MT; Whitaker, AM | 1 |
| Bonfante-Cabarcas, R; Durand Mena, M; Ferrer Mancini, L; Fonseca Zambrano, R; Jiménez Hernández, E; López Hincapié, E; Rodríguez-Bonfante, C | 1 |
| Brown, D; Manaye, KF; Ramlochansingh, C; Tizabi, Y | 1 |
| Dixon-McDougall, T; Nowak, C; Pereira, S; Qian, C; Sellings, L; Tyndale, RF; van der Kooy, D; Zhao, B | 1 |
| Chazono, K; Iwajima, Y; Maeda, Y; Nagano, Y; Ohsawa, M; Ono, H; Yamamoto, S | 1 |
| Albuquerque, EX; Alkondon, M; Pereira, EF | 1 |
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| Antilla, JC; Bickford, PC; Engberg, ME; Hudson, CE; Kang, CW; Lambert, CS; Philpot, RM; Rowell, PP; Wecker, L; Zesiewicz, TA | 1 |
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| Fedotova, IuO | 2 |
| Fedotova, IuO; Sapronov, NS | 1 |
| Danielson, K; Kivell, BM; Putt, F; Truman, P | 1 |
| Feng, CS; Liu, Y; Piao, MH; Qiu, JP; Wang, YS | 1 |
| Bernier, M; Moaddel, R; Paul, RK; Ramamoorthy, A; Singh, NS; Torjman, MC; Wainer, IW | 1 |
| Arora, SK; Rehni, AK; Singh, TG | 1 |
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| Gardner, PD; Liu, L; Pang, X; Tapper, AR; Zhao-Shea, R | 1 |
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| Fay, M; Green, J; Kirshenbaum, A; Parks, A; Phillips, J; Roy, T; Stone, J | 1 |
| Antonelli, MC; Balerio, GN; Bettler, B; Machado, LM; Pedrón, VT; Varani, AP | 1 |
| Malcolm, E; Shoaib, M; Silveira, MM; Winstanley, CA | 1 |
| Alexander, JC; Bauzo-Rodriguez, R; Bruijnzeel, AW; Febo, M; Guerra, V; Hall, G; Igari, M; Klausner, R; Perez, PD; Zeng, H | 1 |
| Brackney, RJ; Daniels, CW; Garcia, R; Mazur, GJ; Sanabria, F; Watterson, E | 1 |
| De Biasi, M; Perez, E; Quijano-Cardé, N | 1 |
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| Banks, ML; Negus, SS; Poklis, JL; Schwienteck, KL | 1 |
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| Carroll, FI; Freitas, K; Negus, SS | 1 |
| Harris, AC; Muelken, P; Schmidt, CE; Shelley, D; Tally, L | 1 |
| Bowers, MS; Damaj, MI; Jackson, A; Maldoon, PP | 1 |
| Abdullah, R; Banks, ML; Bettinger, JC; Carroll, FI; Damaj, IM; Dawson, A; Jackson, A; Miles, MF; Muldoon, PP; O'Brien, M; Slater, CA; Soll, LG; Tapper, AR | 1 |
| Cole, RD; Gould, TJ; Parikh, V; Patel, PJ; Poole, RL | 1 |
| Hardy, DB; Holloway, AC; Wong, MK | 1 |
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| Ghasemzadeh, Z; Rezayof, A; Sardari, M; Tajik, A | 1 |
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| Luo, W; Sun, T; Zhang, C; Zhou, P | 1 |
| Bruijnzeel, AW; Febo, M; Guzhva, L; Qi, X; Shan, Z; Wang, KKW; Yang, Z | 1 |
| Harris, AC; LeSage, MG; Muelken, P; Pentel, PR; Smethells, JR; Staley, M; Stepanov, I; Vogel, RI | 1 |
| Bordia, T; Perez, XA; Quik, M; Zhang, D | 1 |
| Alkahtani, RM; Grider, JR; Lyall, V; Mahavadi, S; Mummalaneni, SK; Murthy, KS; Qian, J | 1 |
| Alvarez-Jimenez, R; Baakman, AC; Goulooze, SC; Groeneveld, GJ; Hart, EP; Rissmann, R; Stevens, J; van Gerven, JM | 1 |
| Café-Mendes, CC; de Sá Lima, L; Ferreira, ZS; Garay-Malpartida, HM; Malta, MB; Marcourakis, T; Markus, RP; Scavone, C | 1 |
| Chaudhri, N; Maddux, JN | 1 |
| de Moura, FB; McMahon, LR | 1 |
| Kovach, AL; Lee, YO; Lefever, TW; Marusich, JA; Silinski, MA; Thomas, BF; Wiley, JL | 1 |
| Alvarez-Jimenez, R; Baakman, AC; den Burger, JCG; Goulooze, SC; Groeneveld, GJ; Klaassen, ES; Rissmann, R; Stevens, J; Swart, EL; van Gerven, JMA | 1 |
| Carcoba, LM; Cruz, B; Flores, RJ; Francis, W; Hinojosa, CA; Ibarra, M; Nazarian, A; O'Dell, LE; Pipkin, JA | 1 |
| Ghasemzadeh, Z; Javadi, P; Rezayof, A; Sardari, M | 1 |
| Belluzzi, JD; Leslie, FM; Malagon, AM; Yasuda, D; Yuan, M; Zaveri, NT | 1 |
| Arias, A; Gueorguieva, R; Jane, JS; Krystal, JH; O'Brien, E; O'Malley, SS; Petrakis, IL; Ralevski, E; Sevarino, KA | 1 |
| Carcoba, LM; Flores, RJ; Natividad, LA; O'Dell, LE | 1 |
| Anderson, KG; Ozga, JE | 1 |
| Feldman, JL; Liang, J; López-Valdés, HE; Shao, XM | 1 |
| Alvarez-Jimenez, R; Cohen, AF; de Kam, M; Groeneveld, GJ; Hart, EP; Prins, S; van Gerven, JMA | 1 |
| Khosravi, M; Lee, LY; Lin, RL; Xu, F | 1 |
| Bockman, CS; Hall, J; Mittelstet, B; Schwarzkopf, L; Stairs, DJ; Zeng, W | 1 |
| Damaj, MI; Jackson, A; Papke, RL | 1 |
| D'Aniello, E; Damaj, MI; Di Marzo, V; Donvito, G; Giordano, C; Guida, F; Ignatowska-Jankowska, BM; Jackson, A; Lichtman, AH; Maione, S; Mechoulam, R; Muldoon, P; Mustafa, MA; Parker, L; Petrie, GN; Piscitelli, F; Sim-Selley, L; Smoum, R; Vitale, RM | 1 |
| Fan, D; Hao, J; Jin, T | 1 |
| Agim, ZS; Cannon, JR; Chester, JA; Weera, MM | 1 |
| Badanavalu, MP; Srivatsan, M | 1 |
| Andersen, ML; Berro, LF; Hirotsu, C; Pedroni, MN; Tufik, S | 1 |
| Groeneveld, GJ; Hart, EP; Linkenkaer-Hansen, K; Mansvelder, HD; Poil, SS; Prins, S; Simpraga, S | 1 |
| McMahon, LR | 1 |
| Cole, M; Harvey, EL; Javadi-Paydar, M; Kerr, TM; Taffe, MA | 1 |
| Bruijnzeel, AW; Esser, KA; Febo, M; Geste, JR; Levin, B; O'Dell, L; Pompilus, M; Wilks, I; Zhang, X | 1 |
| Arreguin, MC; Carcoba, LM; Correa, VL; Flores, RJ; O'Dell, LE | 1 |
| Behnood-Rod, A; Bruijnzeel, AW; Chellian, R; Febo, M; Knight, P; Lyons, H; Panunzio, S; Tan, S; Wilson, R; Xue, S | 1 |
| Inoue, Y; Kadoyama, K; Maekura, K; Matsuura, K; Matsuyama, S; Takano, M | 1 |
| Hsu, LM; Keeley, RJ; Lu, H; Mayer, TE; Stein, EA; Yang, Y | 1 |
| Andersen, EOL; Fischer, L; Gaspar, JC; Guilhen, VA; Lazzarim, MK; Polato, JJ; Sardi, NF; Tobaldini, G | 1 |
| de Moura, FB; McMahon, LR; Wilkerson, JL | 1 |
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| Ahmad, SM; Hamid, A; Lutfy, K; Marquez, P; Nega, S | 1 |
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| Fronius, M; Hollenhorst, MI; Krasteva-Christ, G; Kumar, P; Scholze, P | 1 |
| Chan, TMV; Clarke, PBS; Rahman, S; Ren, S; Satanove, DJ | 1 |
| Concheiro-Guisan, M; Hahn, B; Harvey, AN; Huestis, MA; Ross, TJ; Stein, EA | 1 |
| Prados, J; Sal, F; Urcelay, GP | 1 |
| Ding, ZM; Gao, Y; Sentir, AM; Tan, X | 1 |
| Collazo, J; Friedman, T; Hikim, AS; Jimenez, T; Pervin, S; Singh, R; Singh, V; Sinha, S; Tucker, A; Vadgama, J | 1 |
| Forcelli, PA; LaFlamme, EM; Malkova, L | 1 |
| Harris, AC | 2 |
| Carstens, E; Carstens, MI | 1 |
| Allen, N; Barraza, AG; Dewey, M; Garrett, PI; Hillhouse, TM; Honeycutt, SC; Marston, C; Peterson, AM; Turner, B | 1 |
| Kobayashi, K; Murashita, T; Nishitani, N; Ohmura, Y; Yoshida, T; Yoshioka, M | 1 |
| Deyama, S; Esaki, H; Fukao, A; Ito, S; Izumi, S; Kaneda, K; Nishitani, N | 1 |
| Freels, TG; Klenowski, PM; Molas, S; Tapper, AR; Zhao-Shea, R | 1 |
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| Cruz, B; Galindo, KI; Giner, P; Matos-Ocasio, F; Nazarian, A; O'Dell, LE; Ortegon, S; Rodriguez-Crespo, A; Serafine, KM; Uribe, KP | 1 |
| Al-Harrasi, A; Behl, T; Bhatia, S; Bungau, S; Khan, H; Khan, N; Rather, IIG; Sehgal, A; Sharma, A; Sharma, N; Singh, S | 1 |
| Stratilov, VA; Tyulkova, EI; Vetrovoy, OV | 1 |
| Sawagashira, R; Tanaka, M | 1 |
| Gunn, MD; Huang, MN; Liddle, RA; Shahid, RA; Vigna, SR | 1 |
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20 review(s) available for nicotine and mecamylamine
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic | 2005 |
Ganglionic blocking drugs: general considerations and metabolism.
Topics: Animals; Chemistry; Chlorisondamine; Ganglionic Blockers; Hexamethonium Compounds; History, 19th Century; History, 20th Century; Humans; Mecamylamine; Nicotine; Pempidine; Pentolinium Tartrate; Tetraethylammonium Compounds; Trimethaphan | 1978 |
[Pharmacology of nicotine].
Topics: Cardiovascular System; Humans; Lobeline; Mecamylamine; Metabolism; Nervous System; Nicotine; Respiration; Smoking Prevention | 1992 |
What is the nature of mecamylamine's antagonism of the central effects of nicotine?
Topics: Animals; Brain; Humans; Mecamylamine; Nicotine; Receptors, Nicotinic; Structure-Activity Relationship | 1989 |
Tobacco use, treatment strategies, and pharmacological adjuncts: an overview.
Topics: Bicarbonates; Humans; Legislation, Medical; Lobeline; Mecamylamine; Nicotine; Psychotropic Drugs; Reinforcement, Psychology; Self-Help Groups; Smoking Prevention; Sodium; Sodium Bicarbonate; Taxes; United States | 1985 |
Pharmacologic basis and treatment of cigarette smoking.
Topics: Animals; Chewing Gum; Compulsive Behavior; Conditioning, Operant; Drug Interactions; Humans; Mecamylamine; Nicotine; Recurrence; Reinforcement, Psychology; Self Medication; Smoking Prevention; Substance-Related Disorders; Tobacco Use Disorder | 1984 |
Probing ion channels and recognition sites of neuronal nicotinic cholinergic receptors with novel nicotine affinity and other ligands.
Topics: Affinity Labels; Animals; Azetidines; Binding, Competitive; Brain; Brain Mapping; Calcium; Carbachol; Dithiothreitol; GTP-Binding Proteins; Immunologic Techniques; In Vitro Techniques; Ion Channel Gating; Ligands; Mecamylamine; Nicotine; Receptors, Nicotinic | 1995 |
Acute and chronic nicotinic interactions with dopamine systems and working memory performance.
Topics: Animals; Dopamine; Drug Administration Schedule; Humans; Maze Learning; Mecamylamine; Memory; Nicotine; Receptors, Nicotinic; Substantia Nigra; Ventral Tegmental Area | 1995 |
[Drug aid to tobacco withdrawal].
Topics: Humans; Mecamylamine; Nicotine; Smoking Cessation; Tobacco Use Disorder | 1993 |
Mecamylamine (a nicotine antagonist) for smoking cessation.
Topics: Administration, Cutaneous; Drug Therapy, Combination; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; Smoking Cessation; Smoking Prevention | 2000 |
[Current and future drug therapies for smoking cessation].
Topics: Administration, Cutaneous; Administration, Oral; Anti-Anxiety Agents; Antidepressive Agents; Central Nervous System Stimulants; Chewing Gum; Clinical Protocols; Clonidine; Delayed-Action Preparations; Humans; Lobeline; Mecamylamine; Nebulizers and Vaporizers; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polymethacrylic Acids; Polyvinyls; Smoking; Tobacco Use Cessation Devices | 2001 |
New medications for nicotine dependence treatment.
Topics: Administration, Cutaneous; Administration, Inhalation; Bupropion; Chewing Gum; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; Smoking; Smoking Cessation; Tobacco Use Disorder | 1999 |
Bupropion and other non-nicotine pharmacotherapies.
Topics: Administration, Inhalation; Adrenergic alpha-Agonists; Antidepressive Agents, Second-Generation; Bupropion; Clonidine; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; Smoking Cessation | 2004 |
New findings on nicotine addiction and treatment.
Topics: Animals; Benzazepines; Bupropion; Humans; Mecamylamine; Motivation; Nicotine; Nicotinic Antagonists; Quinoxalines; Reward; Smoking Cessation; Tobacco Use Disorder; Vaccines; Varenicline | 2009 |
The nicotinic acetylcholine receptor as a target for antidepressant drug development.
Topics: Alkaloids; Antidepressive Agents; Azocines; Humans; Mecamylamine; Nicotine; Nicotinic Agonists; Quinolizines; Receptors, Nicotinic | 2012 |
Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond.
Topics: Animals; Basal Ganglia; Depression; Humans; Mecamylamine; Nicotine; Tourette Syndrome; Translational Research, Biomedical | 2012 |
Emerging drugs for the treatment of tobacco dependence: 2014 update.
Topics: Atomoxetine Hydrochloride; Benzazepines; Bupropion; Clinical Trials as Topic; Clonidine; Humans; Mecamylamine; Nicotine; Nortriptyline; Propylamines; Quinoxalines; Tobacco Use Cessation Devices; Tobacco Use Disorder; Varenicline | 2014 |
Green tobacco sickness: mecamylamine, varenicline, and nicotine vaccine as clinical research tools and potential therapeutics.
Topics: Agricultural Workers' Diseases; Humans; Mecamylamine; Nicotiana; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Plant Leaves; Vaccines; Varenicline | 2019 |
Sensory Effects of Nicotine and Tobacco.
Topics: Adolescent; Animals; Female; Humans; Mecamylamine; Nicotiana; Nicotine; Receptors, Nicotinic; Tobacco Products; Tobacco Use | 2022 |
25 trial(s) available for nicotine and mecamylamine
| Article | Year |
|---|---|
[Pharmacology of nicotine].
Topics: Cardiovascular System; Humans; Lobeline; Mecamylamine; Metabolism; Nervous System; Nicotine; Respiration; Smoking Prevention | 1992 |
Mecamylamine increases nicotine preference and attenuates nicotine discrimination.
Topics: Adult; Discrimination, Psychological; Dose-Response Relationship, Drug; Drive; Humans; Male; Mecamylamine; Middle Aged; Nicotine; Personal Satisfaction; Self Administration; Smoking | 1989 |
Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level.
Topics: Adult; Humans; Male; Mecamylamine; Middle Aged; Nicotine; Self Administration | 1987 |
Mecamylamine reduces some EEG effects of nicotine chewing gum in humans.
Topics: Adult; Chewing Gum; Electroencephalography; Humans; Male; Mecamylamine; Middle Aged; Nicotine; Tobacco Use Disorder | 1988 |
Could nicotine antagonists be used in smoking cessation?
Topics: Animals; Clinical Trials as Topic; Double-Blind Method; Humans; Mecamylamine; Nicotine; Receptors, Nicotinic; Smoking Prevention | 1986 |
Effects of nicotine on finger tapping rate in non-smokers.
Topics: Adult; Double-Blind Method; Female; Humans; Male; Mecamylamine; Middle Aged; Motor Activity; Nicotine; Time Factors | 1986 |
Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone.
Topics: Administration, Cutaneous; Adult; Affect; Blood Pressure; Breath Tests; Carbon Monoxide; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Male; Mecamylamine; Nicotine; Patient Compliance; Smoking Cessation; Substance Withdrawal Syndrome; Treatment Outcome | 1994 |
Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy.
Topics: Adult; Affect; Behavior Therapy; Drug Therapy, Combination; Female; Humans; Male; Mecamylamine; Nicotine; Nicotinic Agonists; North Carolina; Smoking Cessation; Time Factors; Tobacco Use Disorder | 1998 |
Effects of central and peripheral nicotinic blockade on human nicotine discrimination.
Topics: Adult; Aged; Discrimination Learning; Female; Humans; Male; Mecamylamine; Middle Aged; Nicotine; Nicotinic Antagonists; Self Administration; Smoking; Trimethaphan | 1999 |
Mecamylamine blockade of both positive and negative effects of IV nicotine in human volunteers.
Topics: Adult; Euphoria; Humans; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Self Administration; Smoking; Time Factors | 2000 |
Nicotine-mecamylamine interactions.
Topics: Administration, Cutaneous; Adult; Area Under Curve; Blood Pressure; Cotinine; Cross-Over Studies; Heart Rate; Humans; Infusions, Intravenous; Male; Mecamylamine; Middle Aged; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Smoking; Time Factors | 2000 |
Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking.
Topics: Administration, Cutaneous; Adolescent; Adult; Analysis of Variance; Arousal; Behavior, Addictive; Blood Pressure; Dizziness; Drug Therapy, Combination; Female; Heart Rate; Humans; Male; Mecamylamine; Middle Aged; Nausea; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Smoking; Substance Withdrawal Syndrome | 2001 |
Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms.
Topics: Administration, Cutaneous; Adult; Female; Humans; Male; Mecamylamine; Monoamine Oxidase; Neostigmine; Nicotine; Nicotinic Antagonists; Parasympathomimetics; Reproducibility of Results; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2001 |
Mecamylamine acutely increases human intravenous nicotine self-administration.
Topics: Adolescent; Adult; Affect; Female; Humans; Injections, Intravenous; Male; Mecamylamine; Middle Aged; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Saliva; Self Administration; Smoking; Substance Withdrawal Syndrome | 2003 |
Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments.
Topics: Administration, Cutaneous; Adult; Behavior Therapy; Extinction, Psychological; Female; Ganglionic Stimulants; Humans; Male; Mecamylamine; Menthol; Middle Aged; Nicotine; Nicotinic Antagonists; Reinforcement, Psychology; Smoking; Smoking Cessation; Tobacco Use Disorder | 2004 |
The influence of mecamylamine on trigeminal and olfactory chemoreception of nicotine.
Topics: Adolescent; Adult; Chemoreceptor Cells; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Evoked Potentials; Humans; Mecamylamine; Middle Aged; Multivariate Analysis; Nicotine; Nicotinic Antagonists; Olfactory Mucosa; Pain Measurement; Sensory Thresholds; Stereoisomerism; Stimulation, Chemical; Trigeminal Nerve | 2006 |
Precessation treatment with nicotine skin patch facilitates smoking cessation.
Topics: Administration, Cutaneous; Adult; Carbon Dioxide; Combined Modality Therapy; Double-Blind Method; Female; Humans; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Saliva; Smoking Cessation; Smoking Prevention; Time Factors | 2006 |
Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia.
Topics: Acute Disease; Adult; Cotinine; Demography; Depression; Female; Humans; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Prevalence; Psychotic Disorders; Receptors, Nicotinic; Recurrence; Schizophrenia; Severity of Illness Index; Smoking Cessation; Smoking Prevention; Substance Withdrawal Syndrome; Surveys and Questionnaires; Tobacco Use Disorder | 2007 |
A randomized, controlled trial to assess the efficacy and safety of a transdermal delivery system of nicotine/mecamylamine in cigarette smokers.
Topics: Administration, Cutaneous; Adult; Aged; Double-Blind Method; Drug Administration Routes; Drug Hypersensitivity; Female; Humans; Male; Mecamylamine; Middle Aged; Nicotine; Nicotinic Antagonists; Safety; Smoking Cessation; Treatment Outcome | 2007 |
Manipulation of nicotinic acetylcholine receptors differentially affects behavioral inhibition in human subjects with and without disordered baseline impulsivity.
Topics: Administration, Cutaneous; Adolescent; Choice Behavior; Double-Blind Method; Female; Humans; Impulsive Behavior; Inhibition, Psychological; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reaction Time; Receptors, Nicotinic; Young Adult | 2012 |
Rate dependent effects of acute nicotine on risk taking in young adults are not related to ADHD diagnosis.
Topics: Administration, Cutaneous; Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Double-Blind Method; Female; Humans; Impulsive Behavior; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Psychiatric Status Rating Scales; Psychomotor Performance; Risk-Taking; Sex Characteristics | 2013 |
An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.
Topics: Adult; Attention; Brain; Cognition; Cross-Over Studies; Double-Blind Method; Electroencephalography; Healthy Volunteers; Humans; Hypnotics and Sedatives; Learning; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Time Factors; Young Adult | 2017 |
Mecamylamine treatment for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcohol Drinking; Alcoholism; Ambulatory Care; Comorbidity; Craving; Double-Blind Method; Female; Humans; Male; Mecamylamine; Middle Aged; Nicotine; Nicotinic Antagonists; Smoking; Substance Withdrawal Syndrome; Treatment Outcome | 2018 |
Reversal of mecamylamine-induced effects in healthy subjects by nicotine receptor agonists: Cognitive and (electro) physiological responses.
Topics: Adolescent; Adult; Cognition; Cross-Over Studies; Double-Blind Method; Drug Interactions; Electroencephalography; Galantamine; Healthy Volunteers; Humans; Male; Mecamylamine; Middle Aged; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reaction Time; Young Adult | 2018 |
An EEG nicotinic acetylcholine index to assess the efficacy of pro-cognitive compounds.
Topics: Adolescent; Adult; Brain Waves; Cholinesterase Inhibitors; Cognition; Drug Evaluation; Galantamine; Humans; Machine Learning; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents | 2018 |
850 other study(ies) available for nicotine and mecamylamine
| Article | Year |
|---|---|
Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.
Topics: Acetylcholine; Animals; Binding Sites; Brain; Female; Nicotine; Piperidines; Pyridines; Pyrrolidines; Rats; Structure-Activity Relationship | 1985 |
Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Design; HEK293 Cells; Humans; Molecular Structure; Nicotinic Antagonists; Receptors, Dopamine D2; Structure-Activity Relationship; Substrate Specificity | 2015 |
Effects of pharmacological agents on [14C]-nicotine distribution and movements in slices from different rat brain areas.
Topics: Animals; Brain; Corpus Striatum; Hydrogen-Ion Concentration; Hypothalamus; In Vitro Techniques; Male; Mecamylamine; Nicotine; Procaine; Rats; Stimulation, Chemical; Temperature; Time Factors | 1975 |
Effects of chemoreceptor stimulating agents on reflex bradycardia.
Topics: Acetylcholine; Animals; Atropine; Carbon Dioxide; Carotid Body; Chemoreceptor Cells; Cyanides; Female; Heart Rate; Hydrogen-Ion Concentration; Male; Mecamylamine; Nicotine; Physostigmine; Rabbits; Reflex; Reserpine | 1979 |
Nicotine self-administration in rats.
Topics: Amphetamine; Animals; Caffeine; Chlordiazepoxide; Chlorpromazine; Drug Interactions; Drug Tolerance; Ethanol; Humans; Male; Mecamylamine; Nicotine; Pentolinium Tartrate; Phenobarbital; Phenytoin; Rats; Reinforcement, Psychology; Self Administration; Substance-Related Disorders | 1979 |
Effects of nicotine, mecamylamine, and hexamethonium on shock-induced fighting, pain reactivity, and locomotor behaviour in rats.
Topics: Aggression; Animals; Electroshock; Hexamethonium Compounds; Humans; Male; Mecamylamine; Motor Activity; Nicotine; Pain; Rats | 1979 |
The influence of adrenergic, dopaminergic, cholinergic and serotoninergic drugs on plasma prolactin levels in ovariectomized, estrogen-treated rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Apomorphine; Arecoline; Atropine; Castration; Clonidine; Dibenzothiepins; Dopamine; Estradiol; Female; Isoproterenol; Mecamylamine; Nicotine; Parasympathomimetics; Phenoxybenzamine; Phentolamine; Pimozide; Piperazines; Prolactin; Rats; Serotonin; Serotonin Antagonists; Stimulation, Chemical; Sulfides | 1975 |
Mecamylamine blockade of nicotine enhanced noradrenaline turnover in rat brain.
Topics: Animals; Brain; Male; Mecamylamine; Methyltyrosines; Nicotine; Norepinephrine; Rats | 1979 |
On the action of nicotine and cotinine on central 5-hydroxytryptamine neurons.
Topics: Amides; Animals; Brain; Cotinine; Fenfluramine; Male; Mecamylamine; Neurons; Nicotine; Pyrrolidinones; Rats; Receptors, Serotonin; Reflex; Serotonin | 1979 |
Central noradrenergic--cholinergic interaction and locomotor behavior.
Topics: Acetylcholine; Animals; Arecoline; Catalepsy; Humans; Hydroxydopamines; Hypothalamus; Male; Mecamylamine; Mesencephalon; Motor Activity; Nicotine; Norepinephrine; Rats; Scopolamine | 1979 |
Cholinergic mechanisms and cataplexy in dogs.
Topics: Animals; Atropine; Cataplexy; Dogs; Female; Humans; Male; Mecamylamine; Neostigmine; Nicotine; Parasympatholytics; Parasympathomimetics; Physostigmine; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine | 1979 |
Comparative studies on anti-nicotinic action of hexamethonium, mecamylamine and adenosine in the guinea pig isolated ileum.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Male; Mecamylamine; Muscle Contraction; Nicotine; Serotonin Antagonists | 1977 |
Release of (3H)norepinephrine from a clonal line of pheochromocytoma cells (PC12) by nicotinic cholinergic stimulation.
Topics: Animals; Atropine; Calcium; Clone Cells; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Magnesium; Mecamylamine; Neoplasms, Experimental; Nerve Growth Factors; Nicotine; Norepinephrine; Pheochromocytoma; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Reserpine; Tubocurarine | 1977 |
Pharmacokinetics of nicotine in adult and infant mice.
Topics: Age Factors; Animals; Brain; Cotinine; Heart Rate; Hexamethonium Compounds; Male; Mecamylamine; Mice; Myocardium; Nicotine; Time Factors; Tremor | 1977 |
A comparison of nicotine and structurally related compounds as discriminative stimuli.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Generalization, Psychological; Male; Mecamylamine; Nicotine; Rats; Reinforcement Schedule | 1978 |
Cholinergic influences on hypothalamic-pituitary-adrenocortical activity of stressed rats: an approach utilizing agonists and antagonists.
Topics: Acoustic Stimulation; Animals; Atropine; Corticosterone; Dexamethasone; Hypercapnia; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mecamylamine; Methacholine Compounds; Nicotine; Parasympathetic Nervous System; Pituitary-Adrenal System; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Stress, Physiological; Vasopressins | 1978 |
The effect of nicotine on central catecholamine neurons and gonadotropin secretion. I. Studies in the male rat.
Topics: Animals; Brain; Catecholamines; Cotinine; Dopamine; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Luteinizing Hormone; Male; Mecamylamine; Neurons; Nicotine; Norepinephrine; Prolactin; Rats | 1977 |
Nicotine in the crude synaptosomal fraction of the rat brain.
Topics: Animals; Brain; Hexamethonium Compounds; Injections, Intraperitoneal; Mecamylamine; Nicotine; Rats; Synaptosomes | 1977 |
Enhancement of sexual behavior in the female rat by nicotine.
Topics: Animals; Apomorphine; Castration; Female; Lysergic Acid Diethylamide; Mecamylamine; Nicotine; Pimozide; Rats; Receptors, Dopamine; Receptors, Serotonin; Sexual Behavior, Animal; Stimulation, Chemical; Sulpiride | 1977 |
Nicotine-induced weight loss in rats without an effect on appetite.
Topics: Animals; Appetite; Body Weight; Depression, Chemical; Feeding Behavior; Female; Hexamethonium Compounds; Mecamylamine; Nicotine; Quinones; Rats; Time Factors | 1976 |
Effect of cholingeric drugs on methadone-induced catalepsy and stereotypies in rats treated chronically with methadone.
Topics: Animals; Atropine; Behavior; Catalepsy; Drug Synergism; Hexamethonium Compounds; Humans; Male; Mecamylamine; Methadone; Nicotine; Parasympathomimetics; Pilocarpine; Rats; Scopolamine; Stereotyped Behavior | 1976 |
The discriminative stimulus properties of nicotine, d-amphetamine and morphine in dopamine depleted rats.
Topics: Animals; Brain Chemistry; Dextroamphetamine; Dopamine; Female; Hydroxydopamines; Mecamylamine; Morphine; Nicotine; Pregnancy; Rats; Time Factors | 1976 |
Drugs and PGO waves in the lateral geniculate body of the curarized cat. IV. The effects of acetylcholine, GABA and benzodiazepines on PGO wave activity.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Acetylcholine; Aminobutyrates; Animals; Arecoline; Atropine; Benzodiazepines; Cats; Chlordiazepoxide; Electroencephalography; gamma-Aminobutyric Acid; Geniculate Bodies; Mecamylamine; Nicotine; Occipital Lobe; Physostigmine; Pons | 1976 |
Nicotine-induced hypophagia and hypodipsia in deprived and in hypothalamically stimulated rats.
Topics: Animals; Depression, Chemical; Drinking Behavior; Electric Stimulation; Feeding Behavior; Food Deprivation; Hexamethonium Compounds; Hypothalamus; Male; Mecamylamine; Nicotine; Rats; Water Deprivation | 1975 |
Nicotine induced tremor and antidiuresis and brain nicotine levels in the rat.
Topics: Animals; Arecoline; Brain; Cotinine; Depression, Chemical; Diuresis; Drug Interactions; Kidney; Liver; Male; Mecamylamine; Nicotine; Rats; Time Factors; Tremor | 1975 |
Presynaptic inhibition of the monosynaptic reflex produced by injections of nicotine or eserine in the spinal cat.
Topics: Animals; Atropine; Blood Pressure; Cats; Depression, Chemical; Gallamine Triethiodide; Mecamylamine; Motor Neurons; Nerve Endings; Neural Conduction; Neurons, Afferent; Nicotine; Physostigmine; Reflex, Monosynaptic; Spinal Cord; Synapses; Time Factors | 1976 |
Cholinergic mediation of the inhibitory effect of methylphenidate on neuronal activity in the reticular formation.
Topics: Animals; Atropine; Female; Hexamethonium Compounds; Male; Mecamylamine; Methylphenidate; Neurons; Nicotine; Oxotremorine; Parasympathetic Nervous System; Rats; Reticular Formation; Time Factors | 1976 |
Nicotine-like behavioral effect after small dose of mecamylamine in Roman high-avoidance rats.
Topics: Animals; Avoidance Learning; Extinction, Psychological; Female; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains | 1976 |
Opioid and nicotinic analgesic and hyperalgesic loci in the rat brain stem.
Topics: Analgesia; Animals; Brain Stem; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Mecamylamine; Microinjections; Naltrexone; Nicotine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1992 |
Nicotine stimulates esophageal peristaltic contractions in cats by a central mechanism.
Topics: Animals; Cats; Deglutition; Electromyography; Esophagus; Female; Hexamethonium; Hexamethonium Compounds; Injections, Intravenous; Male; Mecamylamine; Muscle Relaxation; Muscle, Smooth; Nicotine; Peristalsis; Reference Values; Succinylcholine; Vagotomy | 1992 |
Partial characterization of a neurotransmitter pathway regulating the in vivo release of prolactin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bromocriptine; Haloperidol; Male; Mecamylamine; Methysergide; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Antagonists; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Nicotinic; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
Acute nicotine administration increases somatostatin content and binding in the rat hypothalamus.
Topics: Animals; Cell Membrane; Corpus Striatum; Hypothalamus; Injections, Intravenous; Kinetics; Male; Mecamylamine; Nicotine; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Somatostatin; Somatostatin | 1992 |
Transmitter-like 3,4-dihydroxyphenylalanine is tonically released by nicotine in striata of conscious rats.
Topics: Animals; Calcium; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dihydroxyphenylalanine; Dopamine; Male; Mecamylamine; Neurotransmitter Agents; Nicotine; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1992 |
Nicotinic activity in the interpeduncular nucleus of the midbrain prolongs recovery from halothane anesthesia.
Topics: Anesthesia Recovery Period; Animals; Brain; Female; Ganglionic Blockers; Halothane; Hexamethonium; Hexamethonium Compounds; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Reflex, Abnormal | 1992 |
Intragastric nicotine protection against 40% ethanol injury in rat stomach. Role of ganglionic stimulation or blockade.
Topics: Animals; Blood Pressure; Ethanol; Ganglia, Sympathetic; Ganglionic Blockers; Ganglionic Stimulants; Gastric Juice; Gastric Mucosa; Hexamethonium; Hexamethonium Compounds; Infusions, Parenteral; Male; Mecamylamine; Mucus; Nicotine; Rats; Rats, Sprague-Dawley | 1992 |
[Nicotine-induced ambulatory stimulant effect and its reverse tolerance].
Topics: Animals; Drinking; Drug Tolerance; Haloperidol; Injections, Subcutaneous; Locomotion; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Stimulation, Chemical | 1992 |
Nicotinic and muscarinic components of rat brain dopamine synthesis stimulation induced by physostigmine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Male; Mecamylamine; Muscarine; Nicotine; Physostigmine; Rats; Rats, Sprague-Dawley; Scopolamine | 1992 |
Ethanol-induced locomotor activity: involvement of central nicotinic acetylcholine receptors?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Dose-Response Relationship, Drug; Ethanol; Exploratory Behavior; Hexamethonium Compounds; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Quaternary Ammonium Compounds; Receptors, Nicotinic | 1992 |
Effects of nicotine on the threshold for rewarding brain stimulation in rats.
Topics: Animals; Brain; Electric Stimulation; Male; Mecamylamine; Naloxone; Nicotine; Rats; Rats, Inbred F344; Reward; Self Stimulation | 1992 |
Behavioural effects of anatoxin, a potent nicotinic agonist, in rats.
Topics: Animals; Bacterial Toxins; Behavior, Animal; Cyanobacteria Toxins; Discrimination, Psychological; Ganglionic Stimulants; Male; Marine Toxins; Mecamylamine; Microcystins; Motor Activity; Nicotine; Rats; Tropanes | 1992 |
Effect of acute and subchronic nicotine treatment on cortical efflux of [3H]-D-aspartate and endogenous GABA in freely moving guinea-pigs.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Guinea Pigs; Injections, Intraventricular; Injections, Subcutaneous; Male; Mecamylamine; Methysergide; Naloxone; Nicotine; Receptors, GABA-A; Receptors, Nicotinic | 1991 |
Characterization of the antinociception induced by nicotine in the pedunculopontine tegmental nucleus and the nucleus raphe magnus.
Topics: Analgesia; Animals; Dioxolanes; Glutamates; Glutamic Acid; Hemicholinium 3; Male; Mecamylamine; Medulla Oblongata; Naloxone; Nicotine; Procainamide; Raphe Nuclei; Rats; Rats, Inbred Strains; Reflex | 1991 |
The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats.
Topics: Acetylcholine; Alcohol Drinking; Alcoholism; Animals; Brain Mapping; Brain Tissue Transplantation; Cholinergic Fibers; Discrimination Learning; Ethanol; Fetal Tissue Transplantation; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mental Recall; Mesencephalon; N-Methylscopolamine; Nerve Regeneration; Nicotine; Norepinephrine; Orientation; Parasympatholytics; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Retention, Psychology; Scopolamine; Scopolamine Derivatives | 1991 |
Effects of chronic and subchronic nicotine on tyrosine hydroxylase activity in noradrenergic and dopaminergic neurones in the rat brain.
Topics: Animals; Ataxia; Brain; Dopamine; Drug Administration Schedule; Hexamethonium; Hexamethonium Compounds; Injections, Subcutaneous; Male; Mecamylamine; Motor Activity; Neurons; Nicotine; Norepinephrine; Organ Specificity; Rats; Rats, Inbred Strains; Reference Values; Time Factors; Tyrosine 3-Monooxygenase | 1991 |
Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats: a dose-response and antagonist study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Dopamine; Dose-Response Relationship, Drug; Hexamethonium; Hexamethonium Compounds; Hippocampus; Homovanillic Acid; Male; Mecamylamine; Nicotine; Norepinephrine; Rats; Rats, Inbred Strains | 1991 |
Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia.
Topics: Acetylcholine; Action Potentials; Animals; Bungarotoxins; Ganglia, Parasympathetic; Heart; Hexamethonium Compounds; Ion Channels; Mecamylamine; Neurons; Nicotine; Rats; Receptors, Nicotinic; Sodium; Tubocurarine | 1991 |
Nicotine-induced sensitization to ambulatory stimulant effect produced by daily administration into the ventral tegmental area and the nucleus accumbens in rats.
Topics: Animals; Benzazepines; Male; Mecamylamine; Motor Activity; Nicotine; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Spiperone; Tegmentum Mesencephali | 1992 |
[Studies on the involvement of the nucleus accumbens in the discriminative effects of nicotine in rats].
Topics: Acetylcholine; Animals; Discrimination, Psychological; Dopamine; Injections, Intraventricular; Injections, Subcutaneous; Male; Mecamylamine; Methamphetamine; Nicotine; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1991 |
Cardiac chemoreceptors: pharmacological curiosities or physiological tools?
Topics: Afferent Pathways; Animals; Biguanides; Chemoreceptor Cells; Enkephalin, Leucine; Heart; Hemodynamics; Mecamylamine; Narcotic Antagonists; Nicotine; Rabbits; Receptors, Opioid, delta; Serotonin Antagonists; Tropanes | 1991 |
Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats.
Topics: Acetylcholine; Amnesia; Animals; Avoidance Learning; Blood Pressure; Brain; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Receptors, Cholinergic | 1991 |
Bronchoconstriction and delayed rapid shallow breathing induced by cigarette smoke inhalation in anesthetized rats.
Topics: Airway Resistance; Animals; Bronchoconstriction; Female; Isoproterenol; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Respiration; Smoking | 1991 |
Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze.
Topics: Animals; Choice Behavior; Drug Interactions; Female; Learning; Mecamylamine; Memory; Nicotine; Pilocarpine; Rats; Rats, Inbred Strains; Reference Values; Scopolamine | 1991 |
Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain.
Topics: Animals; Brain Chemistry; Hippocampus; In Vitro Techniques; Iodine Radioisotopes; Mecamylamine; Nicotine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Somatostatin; Synaptic Membranes; Synaptosomes | 1990 |
The importance of nucleus accumbens in nicotine-induced locomotor activity.
Topics: Alkaloids; Animals; Azocines; Male; Mecamylamine; Motor Activity; Nicotine; Nucleus Accumbens; Premedication; Quinolizines; Rats; Rats, Inbred Strains | 1990 |
The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat.
Topics: Animals; Binding, Competitive; Brain; Drug Administration Schedule; Hippocampus; Kinetics; Male; Mecamylamine; Nicotine; Organ Specificity; Parietal Lobe; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Somatostatin; Reference Values; Somatostatin; Substance Withdrawal Syndrome; Substance-Related Disorders | 1990 |
Nicotine indirectly inhibits [3H]dopamine uptake at concentrations that do not directly promote [3H]dopamine release in rat striatum.
Topics: Animals; Binding, Competitive; Carbachol; Chlorisondamine; Cocaine; Corpus Striatum; Dimethylphenylpiperazinium Iodide; Dopamine; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Synaptosomes | 1991 |
Synthesis of 2-exo- and 2-endo-mecamylamine analogues. Structure-activity relationships for nicotinic antagonism in the central nervous system.
Topics: Analgesia; Animals; Chemical Phenomena; Chemistry; Mecamylamine; Mice; Molecular Structure; Motor Activity; Nicotine; Stereoisomerism; Structure-Activity Relationship | 1991 |
Pharmacology of nicotinic receptor-mediated inhibition in rat dorsolateral septal neurones.
Topics: Acetylcholine; Animals; Atropine; Brain; Bungarotoxins; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Membrane Potentials; Nicotine; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tetrodotoxin | 1991 |
Nicotine releases stereoselectively and Ca2(+)-dependently endogenous 3,4-dihydroxyphenylalanine from rat striatal slices.
Topics: Animals; Calcium; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Egtazic Acid; In Vitro Techniques; Kinetics; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Tetrodotoxin | 1990 |
Effect of pCPA on nicotine-induced analgesia.
Topics: Analgesia; Animals; Drug Interactions; Fenclonine; Male; Mecamylamine; Naloxone; Nicotine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds | 1990 |
Role of the fourth cerebroventricle in mediating rat plasma ACTH responses to intravenous nicotine.
Topics: Adrenocorticotropic Hormone; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Mecamylamine; Nicotine; Paraventricular Hypothalamic Nucleus; Rats | 1990 |
Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats.
Topics: Analgesia; Animals; Injections, Spinal; Male; Mecamylamine; Nicotine; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism; Yohimbine | 1990 |
[3H]mecamylamine binding to rat brain membranes. Studies with mecamylamine and nicotine analogues.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cations; Cell Membrane; In Vitro Techniques; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains | 1990 |
Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: comparison with caudate-putamen.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Ascorbic Acid; Caudate Nucleus; Dopamine; Evoked Potentials; Male; Mecamylamine; Nicotine; Nucleus Accumbens; Organ Specificity; Putamen; Rats; Rats, Inbred Strains; Reference Values; Time Factors | 1990 |
Acute effects of nicotine on prolactin release in the rat: agonist and antagonist effects of a single injection of nicotine.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mecamylamine; Morphine; Nicotine; Prolactin; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1990 |
Isobolographic characterization of drug interactions incorporating biological variability.
Topics: Animals; Chloral Hydrate; Drug Interactions; Ethanol; Female; Hexobarbital; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Statistics as Topic | 1990 |
Nicotine conditions place preferences after intracerebral administration in rats.
Topics: Animals; Autoradiography; Choice Behavior; Immunohistochemistry; Injections, Intraventricular; Male; Mecamylamine; Microinjections; Nicotine; Pons; Rats; Rats, Inbred Strains | 1990 |
Behavioral effects after intrathecal administration of cholinergic receptor agonists in the rat.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mecamylamine; Motor Activity; Nicotine; Nociceptors; Parasympathomimetics; Physostigmine; Quinolizines; Rats; Rats, Inbred Strains; Reaction Time; Tacrine | 1990 |
Locomotor activity in rats after administration of nicotinic agonists intracerebrally.
Topics: Alkaloids; Animals; Azocines; Brain; Corpus Striatum; Ganglionic Stimulants; Injections; Injections, Intraventricular; Male; Mecamylamine; Motor Activity; Nicotine; Nucleus Accumbens; Quinolizines; Rats; Thalamus | 1990 |
Nicotine effects in mouse hippocampus are blocked by mecamylamine, but not other nicotinic antagonists.
Topics: Action Potentials; Animals; Atropine; Bungarotoxins; Female; Hippocampus; In Vitro Techniques; Mecamylamine; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic | 1990 |
The effect of etorphine on nicotine- and muscarine-induced catecholamine secretion from perfused rat adrenal glands.
Topics: Acetylcholine; Adrenal Glands; Animals; Epinephrine; Etorphine; Male; Mecamylamine; Morphinans; Muscarine; Nicotine; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Nicotinic; Verapamil | 1990 |
Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine.
Topics: Analgesia; Animals; Brain; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Pempidine; Stereoisomerism; Structure-Activity Relationship | 1990 |
[Drug treatment of nicotine dependence].
Topics: Clonidine; Doxepin; Humans; Imipramine; Mecamylamine; Nicotine; Smoking; Substance Withdrawal Syndrome | 1990 |
Evidence for a central component to the hypotensive action of ketanserin in the dog.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dogs; Ganglionic Blockers; Hexamethonium Compounds; Ketanserin; Mecamylamine; Nicotine; Norepinephrine; Piperidines; Vasoconstriction | 1985 |
Substance P, nicotinic acetylcholine receptors and antinociception in the rat.
Topics: Analgesics; Animals; Hexamethonium Compounds; Injections, Intraventricular; Male; Mecamylamine; Naloxone; Neurokinin A; Neurokinin B; Neuropeptides; Nicotine; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Cholinergic; Substance P | 1987 |
Acute reduction of brain substance P induced by nicotine.
Topics: Animals; Brain; Kinetics; Male; Mecamylamine; Nicotine; Organ Specificity; Rats; Rats, Inbred Strains; Substance P | 1988 |
Nicotine-induced regional changes in brain noradrenaline and dopamine turnover in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain Chemistry; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Hexamethonium Compounds; Male; Mecamylamine; Methoxyhydroxyphenylglycol; Nicotine; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Regionally specific effects of acute and chronic nicotine on rates of catecholamine and 5-hydroxytryptamine synthesis in rat brain.
Topics: Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Dihydroxyphenylalanine; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Time Factors | 1989 |
Further studies on the stimulatory action of nicotine on adrenocortical function in the rat.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Dexamethasone; Dose-Response Relationship, Drug; Hypothalamo-Hypophyseal System; Male; Mecamylamine; Nicotine; Paraventricular Hypothalamic Nucleus; Rats; Receptors, Nicotinic; Time Factors | 1989 |
Effects of nicotinic agonists and antagonists on N-methyl-D-aspartate-induced 3H-norepinephrine release and 3H-(1-[1-(2-thienyl)cyclohexyl]-piperidine) binding in rat hippocampus.
Topics: Animals; Aspartic Acid; Carbachol; Dimethylphenylpiperazinium Iodide; Ganglionic Stimulants; Hexamethonium; Hexamethonium Compounds; Hippocampus; In Vitro Techniques; Mecamylamine; N-Methylaspartate; Nicotine; Norepinephrine; Rats; Receptors, Nicotinic | 1989 |
Mechanisms involved in the respiratory depressant actions of nicotine in anesthetized rats.
Topics: Anesthesia; Animals; Female; Hexamethonium; Hexamethonium Compounds; Mecamylamine; Naltrexone; Nicotine; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Receptors, Opioid; Respiration; Urethane | 1989 |
Nicotine-induced tail-tremor and drug effects.
Topics: Animals; Arecoline; Atropine; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Physostigmine; Rats; Rats, Inbred Strains; Scopolamine; Tail; Tremor | 1989 |
Naltrexone blocks nicotine-induced prolactin release.
Topics: Animals; Catheterization; Male; Mecamylamine; Morphine; Naltrexone; Nicotine; Prolactin; Rats; Rats, Inbred Strains | 1989 |
Nicotine maintains robust self-administration in rats on a limited-access schedule.
Topics: Animals; Dose-Response Relationship, Drug; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Rats; Reinforcement Schedule; Self Administration | 1989 |
Structural requirements for nicotinic antagonists in the CNS.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Mecamylamine; Mice; Motor Activity; Nicotine; Nociceptors; Reaction Time; Receptors, Nicotinic; Structure-Activity Relationship | 1989 |
Nicotine-induced inhibition of cerebellar Purkinje neurons: specific actions of nicotine and selective blockade by mecamylamine.
Topics: Animals; Cerebellum; Heart Conduction System; Iontophoresis; Male; Mecamylamine; Nicotine; Purkinje Fibers; Rats; Rats, Inbred Strains; Stereoisomerism | 1989 |
Uptake and regional distribution of (+)-(R)- and (-)-(S)-N-[methyl-11C]-nicotine in the brains of rhesus monkey. An attempt to study nicotinic receptors in vivo.
Topics: Animals; Brain; Calcium Radioisotopes; Female; Macaca; Macaca mulatta; Mecamylamine; Nicotine; Receptors, Nicotinic; Stereoisomerism; Tomography, Emission-Computed | 1989 |
Electrophysiological evidence for nicotinic and muscarinic modulation of spinal cord reflexes.
Topics: Animals; Atropine; Cats; Electrophysiology; Female; In Vitro Techniques; Male; Mecamylamine; Nicotine; Oxotremorine; Parasympatholytics; Physostigmine; Receptors, Muscarinic; Receptors, Nicotinic; Reflex; Reflex, Monosynaptic; Spinal Cord | 1989 |
Evidence for opioid mechanisms in the behavioral effects of nicotine.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Male; Mecamylamine; Naltrexone; Nicotine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Pharmacologic characterization of nicotine-induced conditioned place preference.
Topics: Animals; Avoidance Learning; Choice Behavior; Conditioning, Operant; Dose-Response Relationship, Drug; Ganglionic Blockers; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains | 1985 |
Hypotensive actions of ketanserin in dogs: involvement of a centrally mediated inhibition of sympathetic vascular tone.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dogs; Female; Heart Rate; Hexamethonium; Hexamethonium Compounds; Ketanserin; Male; Mecamylamine; Nicotine; Piperidines; Sympathetic Nervous System; Vascular Resistance; Vasomotor System | 1985 |
Nicotine-induced respiratory effects of cigarette smoke in dogs.
Topics: Animals; Blood; Bronchial Spasm; Dogs; Female; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Muscle Contraction; Nicotiana; Nicotine; Phrenic Nerve; Plants, Toxic; Respiration; Smoke; Trachea | 1985 |
The action of cholinomimetic and cholinolytic agents, hemicholinium-3 and alpha- and beta-bungarotoxin on the body wall muscle of the earthworm, Lumbricus terrestris.
Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bungarotoxins; Carbachol; Choline; Decamethonium Compounds; Gallamine Triethiodide; Hemicholinium 3; Hexamethonium; Hexamethonium Compounds; Mecamylamine; Muscles; Nicotine; Oligochaeta; Parasympatholytics; Parasympathomimetics; Physostigmine; Quaternary Ammonium Compounds; Receptors, Cholinergic; Succinylcholine; Tubocurarine | 1985 |
Inhibition by neosurugatoxin of nicotine-induced antinociception.
Topics: Animals; Central Nervous System; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mice; Mollusk Venoms; Nicotine; Pain; Pempidine; Receptors, Nicotinic | 1986 |
Increases in dopamine utilization in certain limbic dopamine terminal populations after a short period of intermittent exposure of male rats to cigarette smoke.
Topics: Animals; Cotinine; Dopamine; Limbic System; Male; Mecamylamine; Methyltyrosines; Nerve Endings; Nicotiana; Nicotine; Plants, Toxic; Rats; Rats, Inbred Strains; Smoke; Telencephalon; Tyrosine 3-Monooxygenase | 1986 |
Locomotor activity as a predictor of times and dosages for studies of nicotine's neurochemical actions.
Topics: Acetylcholine; Animals; Brain; Carbohydrate Metabolism; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Hexamethonium; Hexamethonium Compounds; Injections, Intraperitoneal; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Time Factors | 1987 |
Nicotine enhances delayed matching-to-sample performance by primates.
Topics: Animals; Dose-Response Relationship, Drug; Hexamethonium; Hexamethonium Compounds; Macaca fascicularis; Mecamylamine; Memory; Mental Processes; Nicotine; Time Factors | 1988 |
Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Male; Mecamylamine; Nerve Endings; Nicotine; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei | 1989 |
Withdrawal from chronic nicotine substitutes partially for the interoceptive stimulus produced by pentylenetetrazol (PTZ).
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Pentylenetetrazole; Rats; Substance Withdrawal Syndrome | 1986 |
Discriminative stimulus effects of a nicotine-midazolam mixture in rats.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Mecamylamine; Midazolam; Nicotine; Rats | 1987 |
Chronic nicotine exposure: studies on water intake, body weight, blood pressure and behavior.
Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Cue properties of oral and transdermal nicotine in the rat.
Topics: Administration, Cutaneous; Administration, Oral; Alkaloids; Animals; Azocines; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Female; Mecamylamine; Nicotine; Ovariectomy; Quinolizines; Rats; Reinforcement Schedule; Time Factors | 1988 |
Antagonism of the nicotine-induced changes of the striatal dopamine metabolism in mice by mecamylamine and pempidine.
Topics: Animals; Body Temperature Regulation; Corpus Striatum; Dopamine; Male; Mecamylamine; Metallothionein 3; Mice; Nicotine; Pempidine | 1988 |
Action of acetylcholine, muscarine, nicotine and antagonists on the membrane potential of astrocytes in cultured rat brainstem and spinal cord.
Topics: Acetylcholine; Animals; Astrocytes; Atropine; Brain Stem; Cells, Cultured; Mecamylamine; Membrane Potentials; Muscarine; Nicotine; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Spinal Cord | 1988 |
Prenatal cholinergic stimulation of pulmonary neuroendocrine cells by nicotine.
Topics: Animals; Calcitonin; Cricetinae; Female; Lung; Mecamylamine; Mesocricetus; Nicotine; Pregnancy; Receptors, Cholinergic | 1988 |
Evidence for a nicotinic component to the actions of acetylcholine in cat visual cortex.
Topics: Animals; Binding, Competitive; Cats; Evoked Potentials, Visual; Geniculate Bodies; Kinetics; Mecamylamine; Nicotine; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Subcellular Fractions; Visual Cortex | 1988 |
Genetic differences in plasma corticosterone levels in response to nicotine injection.
Topics: Animals; Corticosterone; Female; Kinetics; Male; Mecamylamine; Mice; Mice, Inbred A; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Nicotine; Reference Values; Species Specificity | 1988 |
Volitional oral intake of nicotine in tupaias: drug-induced alterations.
Topics: 5-Hydroxytryptophan; Administration, Oral; Animals; Dose-Response Relationship, Drug; Drinking; Female; Male; Mecamylamine; Motivation; Nicotine; Pyrimidines; Quipazine; Self Administration; Tupaia | 1988 |
Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle.
Topics: Acetylcholine; Animals; Carbachol; Cattle; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Hexamethonium Compounds; Lidocaine; Male; Mecamylamine; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nicotine; Oxygen; Penis; Scopolamine; Tetrodotoxin | 1988 |
Nicotine enhances cerebral glucose utilization in central components of the rat visual system.
Topics: Animals; Autoradiography; Brain; Deoxy Sugars; Deoxyglucose; Geniculate Bodies; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred F344; Superior Colliculi; Visual Pathways | 1988 |
Effects of nicotine on ambulatory activity in mice.
Topics: Animals; Atropine; Brain; Dose-Response Relationship, Drug; Hexamethonium Compounds; Injections, Subcutaneous; Male; Mecamylamine; Mice; Motor Activity; Nicotine | 1988 |
Cardiovascular effects of cholinergic agents in the ventral-lateral midbrain periaqueductal gray of the rat.
Topics: Animals; Atropine; Atropine Derivatives; Blood Pressure; Heart Rate; Hemodynamics; Hexamethonium Compounds; Injections; Male; Mecamylamine; Mesencephalon; Nicotine; Parasympathomimetics; Periaqueductal Gray; Rats; Rats, Inbred Strains | 1987 |
The response of suprachiasmatic neurons of the rat hypothalamus to photic and nicotinic stimuli.
Topics: Action Potentials; Animals; Hypothalamus, Anterior; Male; Mecamylamine; Nicotine; Photic Stimulation; Rats; Rats, Inbred Strains; Suprachiasmatic Nucleus | 1987 |
Nonmuscarinic neurotoxicity of oxotremorine.
Topics: Animals; Arecoline; Atropine; Atropine Derivatives; Benactyzine; Benztropine; Crying; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Nervous System; Nicotine; Oxotremorine; Pilocarpine; Rats; Rats, Inbred Strains; Salivation; Scopolamine; Seizures; Time Factors | 1987 |
Marked up-regulation of the beta-bungarotoxin site in adrenal chromaffin cells by specific nicotinic antagonists.
Topics: Adrenal Medulla; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Bungarotoxins; Carbachol; Cattle; Chromaffin Granules; Chromaffin System; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Hexamethonium Compounds; Mecamylamine; Nicotine; Receptors, Cholinergic; Receptors, Nicotinic; Tetrodotoxin; Tubocurarine; Veratridine | 1987 |
Nicotine-induced changes in the metabolism of specific brain proteins.
Topics: Animals; Brain; Brain Chemistry; Drug Tolerance; Electrophoresis, Polyacrylamide Gel; Mecamylamine; Nerve Tissue Proteins; Nicotine; Rats | 1987 |
Nicotinic cholinergic influences on sexual receptivity in female rats.
Topics: Animals; Atropine; Cerebral Ventricles; Female; Mecamylamine; Nicotine; Ovariectomy; Physostigmine; Posture; Rats; Rats, Inbred Strains; Sexual Behavior, Animal | 1987 |
Development of amygdaloid cholinergic mediation of passive avoidance learning in the rat. II. Nicotinic mechanisms.
Topics: Acetylcholine; Amygdala; Animals; Avoidance Learning; Cholinergic Fibers; Conditioning, Classical; Female; Male; Mecamylamine; Microinjections; Nicotine; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Nicotinic | 1987 |
Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine.
Topics: Action Potentials; Anesthesia; Animals; Apomorphine; Dopamine; Male; Mecamylamine; Neurons; Nicotine; Rats; Rats, Inbred Strains; Stimulation, Chemical; Tegmentum Mesencephali | 1987 |
Motor responses of autoimmune NZB/B1NJ and C57BL/6Nnia mice to arecoline and nicotine.
Topics: Animals; Arecoline; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Inbred NZB; Motor Activity; Nicotine; Receptors, Muscarinic; Scopolamine; Silicone Oils; Tremor | 1987 |
Mecamylamine blockade of nicotine responses: evidence for two brain nicotinic receptors.
Topics: Animals; Body Temperature; Brain; Brain Chemistry; Bungarotoxins; Dose-Response Relationship, Drug; Female; Heart Rate; Iodine Radioisotopes; Male; Mecamylamine; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Nicotine; Receptors, Nicotinic; Reflex, Startle; Species Specificity | 1986 |
Nicotinic effects on the firing pattern of midbrain dopamine neurons.
Topics: Animals; Behavior, Animal; Male; Mecamylamine; Mesencephalon; Neurons; Nicotine; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1986 |
Cat carotid body chemoreceptor responses before and after nicotine receptor blockade with alpha-bungarotoxin.
Topics: Action Potentials; Animals; Bungarotoxins; Carotid Body; Cats; Chemoreceptor Cells; Mecamylamine; Nicotine; Oxygen; Receptors, Nicotinic; Sodium Cyanide | 1987 |
Pharmacological effects of 1,2,3,5,6,10b-hexahydropyrido[2,3g]indolizine, a bridged-nicotine analog.
Topics: Analgesics; Animals; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Ileum; Indolizines; Male; Mecamylamine; Mice; Muscle Contraction; Nicotine; Rats; Rats, Inbred Strains; Stereoisomerism | 1986 |
Mecamylamine, but not atropine, antagonizes nicotine-induced hyperglycemia and potentiation of hypnosis produced by pentobarbital in mice.
Topics: Animals; Atropine; Blood Glucose; Drug Synergism; Hyperglycemia; Hypnosis, Anesthetic; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Pentobarbital; Sleep | 1986 |
Effects of nicotine on schedule-controlled behaviour. Role of fixed-interval length and modification by mecamylamine and chlorpromazine.
Topics: Animals; Behavior, Animal; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Reinforcement Schedule; Time Factors | 1985 |
In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Brain; Cerebral Cortex; Corpus Striatum; Cotinine; Dihydro-beta-Erythroidine; Ganglionic Stimulants; Hypothalamus; Isoflurophate; Male; Mecamylamine; Nicotine; Quinolizines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Thalamus | 1985 |
Cholinergic regulation of neocortical spindling in DBA/2 mice.
Topics: Animals; Atropine; Cerebral Cortex; Electroencephalography; Female; Male; Mecamylamine; Mice; Mice, Inbred DBA; Nicotine; Parasympathetic Nervous System; Pentylenetetrazole; Physostigmine; Pons | 1985 |
Electrophysiological actions of nicotine on substantia nigra single units.
Topics: Animals; Chlorisondamine; Dopamine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Mecamylamine; Neurons; Nicotine; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Mecamylamine pretreatment counteracts cigarette smoke induced changes in hypothalamic catecholamine neuron systems and in anterior pituitary function.
Topics: Animals; Corticosterone; Cotinine; Dopamine; Gonadotropins, Pituitary; Hypothalamus; Male; Mecamylamine; Methyltyrosines; Neurons; Nicotine; Norepinephrine; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Smoke; Thyrotropin | 1985 |
Some pharmacologic characteristics of the human vas deferens.
Topics: Acetylcholine; Adrenergic beta-Agonists; Adult; Chemoreceptor Cells; Dose-Response Relationship, Drug; Epinephrine; Histamine; Humans; Isoproterenol; Male; Mecamylamine; Middle Aged; Neostigmine; Neurotransmitter Agents; Nicotine; Norepinephrine; Phentolamine; Serotonin; Vas Deferens | 1973 |
Some pharmacologic characteristics of the human vas deferens.
Topics: Acetylcholine; Adrenergic beta-Agonists; Adult; Chemoreceptor Cells; Dose-Response Relationship, Drug; Epinephrine; Histamine; Humans; Isoproterenol; Male; Mecamylamine; Middle Aged; Neostigmine; Neurotransmitter Agents; Nicotine; Norepinephrine; Phentolamine; Serotonin; Vas Deferens | 1973 |
The effects of ganglion blocking agents on the isolated, innervated bladder of the guinea-pig.
Topics: Animals; Ganglionic Blockers; Guinea Pigs; Hexamethonium Compounds; Mecamylamine; Nicotine; Pelvis; Pentolinium Tartrate; Piperazines; Urinary Bladder | 1973 |
Non-nicotinic transmission during ganglionic block with chlorisondamine and nicotine.
Topics: Animals; Atropine; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Cats; Chlorisondamine; Drug Synergism; Electric Stimulation; Ganglionic Blockers; Hexamethonium Compounds; In Vitro Techniques; Mecamylamine; Muscle Contraction; Nicotine; Nictitating Membrane; Physostigmine; Receptors, Cholinergic; Synaptic Transmission; Time Factors | 1973 |
Analysis of mode of action of some nicotinic blocking drugs.
Topics: Animals; Chlorisondamine; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Ganglionic Blockers; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Kinetics; Mecamylamine; Muscle Contraction; Nicotine; Pempidine; Pentolinium Tartrate; Rabbits; Tetraethylammonium Compounds | 1973 |
Central nervous system and autonomic nervous system effects of amantadine and of some standard anti-Parkinson drugs.
Topics: Amantadine; Animals; Antiparkinson Agents; Atropine; Autonomic Nervous System; Body Temperature; Carbachol; Central Nervous System; Dihydroxyphenylalanine; Drug Interactions; Gastrointestinal Motility; Male; Mecamylamine; Mice; Mydriatics; Nicotine; Oxotremorine; Phenothiazines; Pupil; Rats; Trihexyphenidyl | 1973 |
Impulse transmission via nicotinic and muscarinic pathways in the stellate ganglion of the dog.
Topics: Animals; Atropine; Biphenyl Compounds; Blood Pressure; Chlorisondamine; Dogs; Electric Stimulation; Extracorporeal Circulation; Heart Rate; Hexamethonium Compounds; Mecamylamine; Morphine; Nicotine; Parasympathetic Nervous System; Parasympatholytics; Physostigmine; Stellate Ganglion; Sympathetic Nervous System; Synaptic Transmission; Tetraethylammonium Compounds; Tubocurarine; Vagus Nerve | 1968 |
Actions of anticholinesterase agents upon ganglionic transmission in the dog.
Topics: Animals; Atropine; Biphenyl Compounds; Blood Pressure; Chlorisondamine; Cholinesterase Inhibitors; Cholinesterases; Dogs; Electric Stimulation; Ganglia, Autonomic; Heart Rate; Hexamethonium Compounds; Mecamylamine; Nicotine; Parasympatholytics; Physostigmine; Stellate Ganglion; Synaptic Transmission | 1968 |
Mechanism of the musculotropic activity of angiotensin on the isolated guinea-pig seminal vsecile.
Topics: Acetylcholine; Angiotensin II; Animals; Atropine; Catecholamines; Cocaine; Epinephrine; Guanethidine; Guinea Pigs; Male; Mecamylamine; Muscle Contraction; Muscle, Smooth; Nicotine; Phentolamine; Piperazines; Seminal Vesicles; Tachyphylaxis; Tetracaine; Tyramine | 1968 |
Effects of nicotine, dimethylphenylpiperazinium and cholinergic blocking agents at adrenergic nerve endings of the rabbit pulmonary artery.
Topics: Animals; Electric Stimulation; Hexamethonium Compounds; In Vitro Techniques; Mecamylamine; Muscle Contraction; Nerve Endings; Nicotine; Norepinephrine; Parasympatholytics; Piperazines; Pulmonary Artery; Rabbits; Sensory Receptor Cells; Sympathetic Nervous System; Synaptic Transmission; Tubocurarine; Tyramine | 1969 |
Drug receptor sites in the isolated superior cervical ganglion of the rat.
Topics: Acetylcholine; Angiotensin II; Animals; Atropine; Bradykinin; Carbachol; Carbamates; Cholinesterase Inhibitors; Cholinesterases; Female; Ganglia, Autonomic; Hexamethonium Compounds; Histamine; Kinetics; Male; Mecamylamine; Methacholine Compounds; Neurons; Nicotine; Physostigmine; Pilocarpine; Piperazines; Quaternary Ammonium Compounds; Rats; Receptors, Drug; Sensory Receptor Cells; Serotonin; Sympathomimetics; Tubocurarine | 1970 |
Muscarinic mediation of the biphasic temperature response to intrahypothalamic injections of carbachol in the cat.
Topics: Animals; Atropa belladonna; Body Temperature Regulation; Carbachol; Cats; Hypothalamus; Male; Mecamylamine; Nicotine; Oxotremorine; Parasympatholytics; Parasympathomimetics; Plants, Medicinal; Plants, Toxic; Receptors, Cholinergic; Species Specificity; Synaptic Transmission | 1974 |
Pharmacological observations on the hypotensive action of extracts of teleost fish Urophyses (urotensin I) in the rat.
Topics: Acetylcholine; Angiotensin II; Animals; Atropine; Blood Pressure; Bradykinin; Diphenhydramine; Epinephrine; Female; Fishes; Heart Rate; Hexamethonium Compounds; Hypotension; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Norepinephrine; Peptides; Perfusion; Phenoxybenzamine; Propranolol; Rats; Time Factors; Tissue Extracts | 1974 |
A direct and an indirect action of 5-hydroxytryptamine on the distal part of the isolated colon of the rat.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Cocaine; Colon; Hexamethonium Compounds; Histamine; Lysergic Acid Diethylamide; Male; Mecamylamine; Muscle Contraction; Muscle, Smooth; Nicotine; Piperazines; Procaine; Rats; Scopolamine; Serotonin | 1965 |
The effects of arecoline on spinal reflexes of the cat.
Topics: Acetylcholine; Animals; Atropine; Bethanechol Compounds; Blood Pressure; Cats; Female; Male; Mecamylamine; Nicotine; Nitroglycerin; Parasympathomimetics; Quaternary Ammonium Compounds; Reflex; Spinal Cord; Tremorine | 1965 |
The site of action of drugs on the isolated taenia caeci from the guinea-pig.
Topics: Acetylcholine; Animals; Cecum; Cocaine; Female; Guinea Pigs; Hexamethonium Compounds; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Insecticides; Lysergic Acid Diethylamide; Male; Mecamylamine; Morphine; Muscle Contraction; Nicotine; Piperazines; Procaine; Scopolamine; Serotonin; Sympathomimetics | 1966 |
An analysis of the sympathomimetic effects of acetylcholine of the rat ileum.
Topics: Acetylcholine; Amphetamine; Animals; Bretylium Compounds; Choline; Cocaine; Dextroamphetamine; Drug Synergism; Epinephrine; Ethanolamines; Female; Guanethidine; Hexamethonium Compounds; Ileum; In Vitro Techniques; Male; Mecamylamine; Muscle Contraction; Muscle, Smooth; Nicotine; Pempidine; Phentolamine; Rats; Reserpine; Scopolamine; Xylenes | 1967 |
[Mechanism of contraction caused by nicotine on the isolated rabbit aorta, with reference to catecholamine release].
Topics: Animals; Aorta; Autonomic Agents; Bis-Trimethylammonium Compounds; Bretylium Compounds; Catecholamines; Cocaine; Edetic Acid; Ergotamine; Guanethidine; Hexamethonium Compounds; Hydrazines; In Vitro Techniques; Mecamylamine; Muscle Contraction; Nicotine; Norepinephrine; Pyrogallol; Rabbits; Reserpine; Tyramine; Yohimbine | 1967 |
Dual transmission in the stellate ganglion of the dog.
Topics: Acetylcholine; Animals; Atropine; Chlorisondamine; Cordotomy; Depression, Chemical; Dogs; Ganglionic Blockers; Hexamethonium Compounds; Isoflurophate; Mecamylamine; Neostigmine; Nicotine; Parasympatholytics; Physostigmine; Scopolamine; Stellate Ganglion; Synaptic Transmission; Tetraethylammonium Compounds; Tubocurarine | 1968 |
Effects of ganglion blocking agents on nicotine extensor convulsions and lethality in mice.
Topics: Animals; Atropine; Cerebral Ventricles; Chlorisondamine; Chlorpromazine; Decamethonium Compounds; Ganglionic Blockers; Hexamethonium Compounds; Male; Mecamylamine; Mice; Morphine; Nicotine; Phenobarbital; Seizures | 1969 |
The pharmacology of the cholinoceptor in muscle preparations of Ascaris lumbricoides var. suum.
Topics: Acetylcholine; Animals; Ascaris; Atropine; Barium; Carbachol; Cholinesterase Inhibitors; Decamethonium Compounds; Epinephrine; Ganglionic Blockers; Hexamethonium Compounds; In Vitro Techniques; Mecamylamine; Muscles; Nicotine; Parasympatholytics; Piperazines; Potassium; Receptors, Drug; Tubocurarine | 1969 |
Antagonism by antimuscarinic and ganglion-blocking drugs of some of the behavioural effects of nicotine.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Blood Pressure; Chlorisondamine; Conditioning, Operant; Ganglionic Blockers; Male; Mecamylamine; Nicotine; Parasympatholytics; Pupil; Rats; Scopolamine | 1969 |
The triphasic response of the isolated superior cervical ganglion of the rat to cholinergic stimulants.
Topics: Acetylcholine; Action Potentials; Animals; Carbachol; Dextroamphetamine; Dibenzylchlorethamine; Epinephrine; Ethanolamines; Ganglia, Spinal; Guanethidine; Hexamethonium Compounds; Isoproterenol; Mecamylamine; Nicotine; Norepinephrine; Parasympathomimetics; Phentolamine; Physostigmine; Pilocarpine; Piperazines; Rats; Scopolamine; Tetraethylammonium Compounds; Tubocurarine | 1972 |
Effects of suberyldicholine on carotid baroreceptors and chemoreceptors.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Caprylates; Carotid Arteries; Cats; Chemoreceptor Cells; Choline; Cyanides; Dicarboxylic Acids; Dose-Response Relationship, Drug; Female; Injections, Intra-Arterial; Male; Mecamylamine; Neurons; Nicotine; Perfusion; Pressoreceptors; Time Factors; Tubocurarine | 1974 |
Effect of oxotremorine on homovanillic acid concentration in the striatum of the rat.
Topics: Animals; Arecoline; Atropine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Fluorometry; Hemicholinium 3; Homovanillic Acid; Male; Mecamylamine; Nicotine; Oxotremorine; Parasympathomimetics; Phenylacetates; Physostigmine; Rats; Time Factors | 1974 |
Nicotine hypothermia and brain nicotine and catecholamine levels in the mouse.
Topics: Animals; Body Temperature; Brain; Brain Chemistry; Chemoreceptor Cells; Depression, Chemical; Dopamine; Hexamethonium Compounds; Levodopa; Male; Mecamylamine; Methyltyrosines; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Norepinephrine; Time Factors | 1974 |
Studies on the time course and the effect of cholinergic and adrenergic receptor blockers on the stimulus effect of nicotine.
Topics: Animals; Atropine; Brain Chemistry; Conditioning, Operant; Dibenzylchlorethamine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Methyltyrosines; Nicotine; Parasympatholytics; Propranolol; Rats; Receptors, Cholinergic; Reinforcement Schedule; Stimulation, Chemical; Sympatholytics; Time Factors | 1974 |
Influencing cigarette smoking with nicotine antagonists.
Topics: Adolescent; Adult; Blood Pressure; Central Nervous System; Humans; Mecamylamine; Nicotiana; Nicotine; Pentolinium Tartrate; Plants, Toxic; Reinforcement, Psychology; Smoking; Stimulation, Chemical; Task Performance and Analysis | 1973 |
Temperature responses in the rat and cat to cholinomimetic drugs injected into the cerebral ventricles.
Topics: Acetylcholine; Animals; Atropine; Body Temperature Regulation; Cats; Cerebral Ventricles; Ganglionic Stimulants; Injections; Male; Mecamylamine; Methacholine Compounds; Nicotine; Parasympathomimetics; Physostigmine; Rats; Species Specificity; Time Factors | 1973 |
Cardiovascular responses to injections of cholinomimetic drugs into the cerebral ventricles of unanaesthetized dogs.
Topics: Acetylcholine; Animals; Atropine; Behavior, Animal; Blood Pressure; Cerebral Ventricles; Dogs; Drug Tolerance; Female; Heart Rate; Male; Mecamylamine; Methacholine Compounds; Nicotine; Parasympathomimetics; Physostigmine; Sympathomimetics; Time Factors | 1973 |
Muscle relaxation by drugs which stimulate sensory nerve endings. II. The effect of nicotinic agents.
Topics: Acetylcholine; Anesthesia, Inhalation; Animals; Blood Pressure; Cats; Chloralose; Decerebrate State; Depression, Chemical; Electromyography; Femoral Nerve; Ganglionic Stimulants; Hexamethonium Compounds; Mecamylamine; Motor Activity; Muscles; Neuromuscular Depolarizing Agents; Nicotine; Reflex, Stretch; Succinylcholine; Synapses; Urethane | 1973 |
Drug-induced catalepsy as influenced by psychostimulants, apomorphine, L-dopa, and yohimbine.
Topics: Amphetamine; Animals; Apomorphine; Catalepsy; Dihydroxyphenylalanine; Hallucinogens; Haloperidol; Humans; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Paraoxon; Pempidine; Phenmetrazine; Pilocarpine; Sparteine; Tetrabenazine; Trifluoperazine; Yohimbine | 1973 |
Antin ociceptive activity of nicotine.
Topics: Acetates; Analgesia; Animals; Dimethylphenylpiperazinium Iodide; Drug Tolerance; Injections, Intraperitoneal; Mecamylamine; Methods; Mice; Nicotine; Oxotremorine; Pain; Physostigmine; Rats; Reaction Time; Seizures; Tremorine | 1973 |
Intrahippocampal application of cholinergic agents and blockers: effects on rats in differential reinforcement of low rates and Sidman avoidance paradigms.
Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Hippocampus; Inhibition, Psychological; Male; Mecamylamine; Methacholine Compounds; Nicotine; Parasympatholytics; Parasympathomimetics; Rats; Receptors, Cholinergic; Reinforcement Schedule; Scopolamine | 1974 |
Reduced behavioral effects of pilocarpine during chronic treatment with DFP.
Topics: Animals; Atropine; Brain Chemistry; Cholinesterases; Conditioning, Operant; Depression, Chemical; Drinking Behavior; Drug Tolerance; Isoflurophate; Male; Mecamylamine; Nicotine; Pilocarpine; Rats; Receptors, Drug; Stimulation, Chemical; Time Factors; Water | 1974 |
Cholinergic modification of naloxone-induced jumping in morphine dependent mice.
Topics: Animals; Arecoline; Atropine; Behavior, Animal; Benztropine; Brain Chemistry; Dimethylphenylpiperazinium Iodide; Humans; Lobeline; Male; Mecamylamine; Mice; Mice, Inbred ICR; Morphine Dependence; Naloxone; Nicotine; Oxotremorine; Parasympatholytics; Parasympathomimetics; Pempidine; Physostigmine; Pilocarpine; Tremorine; Tritium | 1974 |
Effects of nicotine on self-stimulation in rats.
Topics: Amphetamine; Analysis of Variance; Animals; Female; Hypothalamus; Male; Mecamylamine; Nicotine; Phenobarbital; Rats; Self Stimulation; Stereotaxic Techniques; Stimulation, Chemical; Vasopressins | 1971 |
Titration of oral nicotine intake with smoking behaviour in monkeys.
Topics: Administration, Oral; Animals; Drug Interactions; Haplorhini; Macaca; Mecamylamine; Nicotine; Smoking | 1971 |
Effect of mecamylamine on discrimination between nicotine- and arecoline- produced cues.
Topics: Animals; Behavior, Animal; Cues; Discrimination Learning; Electroshock; Female; Mecamylamine; Nicotine; Nicotinic Acids; Rats; Rats, Inbred Strains; Statistics as Topic | 1972 |
Changes in body temperature produced by cholinomimetic substances injected into the cerebral ventricles of unanaesthetized cats.
Topics: Acetylcholine; Animals; Atropine; Autonomic Agents; Blood Vessels; Body Temperature Regulation; Carbachol; Cats; Cerebral Ventricles; Hexamethonium Compounds; Hypothalamus; Male; Mecamylamine; Nicotine; Norepinephrine; Physostigmine; Receptors, Drug; Shivering | 1972 |
Effects of cholinergic agonists and antagonists on self-stimulation behavior in the rat.
Topics: Animals; Atropine; Conditioning, Operant; Electric Stimulation; Electrodes, Implanted; Hypothalamus; Injections, Intraperitoneal; Male; Mecamylamine; Methamphetamine; Neostigmine; Nicotine; Parasympatholytics; Parasympathomimetics; Physostigmine; Pilocarpine; Rats; Receptors, Cholinergic; Scopolamine; Self Stimulation | 1972 |
C.N.S. effect of nicotine as the discriminative stimulus for the rat in a T-maze.
Topics: Animals; Brain; Discrimination Learning; Female; Hexamethonium Compounds; Mecamylamine; Nicotine; Rats; Time Factors | 1971 |
Differential effects of cholinergic agonists on self-stimulation and escape behavior.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain; Brain Chemistry; Electric Stimulation; Electrodes; Escape Reaction; Hypothalamus; Male; Mecamylamine; Mesencephalon; Neostigmine; Nicotine; Nicotinic Acids; Parasympathomimetics; Physostigmine; Rats; Scopolamine; Self Stimulation | 1969 |
Nicotine injections as the conditioned stimulus in discrimination learning.
Topics: Amphetamine; Animals; Apomorphine; Caffeine; Chlordiazepoxide; Chlorisondamine; Conditioning, Operant; Discrimination Learning; Electroshock; Epinephrine; Gallamine Triethiodide; Male; Mecamylamine; Nicotine; Noise; Phenobarbital; Physostigmine; Rats; Water | 1969 |
Comparative study of the actions of nicotine and succinylcholine on the monosynaptic reflex and spindle afferent activity.
Topics: Animals; Cats; Denervation; Gallamine Triethiodide; Mecamylamine; Motor Activity; Nerve Endings; Neurons; Nicotine; Reflex, Monosynaptic; Sensory Receptor Cells; Succinylcholine; Synapses | 1969 |
Effects of nicotine on fixed-interval behavior and their modification by cholinergic antagonists.
Topics: Animals; Conditioning, Operant; Dextroamphetamine; Drug Tolerance; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Nicotinic Acids; Parasympatholytics; Rats; Reinforcement Schedule; Scopolamine | 1970 |
Effects of nicotine and tobacco smoke on the electrical activity of the cerebral cortex and olfactory bulb.
Topics: Animals; Atropine; Blood Pressure; Carbon Monoxide; Cats; Cerebral Cortex; Chlorpromazine; Electroencephalography; Evoked Potentials; Female; Filtration; Limbic System; Male; Mecamylamine; Nicotiana; Nicotine; Pentobarbital; Plants, Toxic | 1970 |
Drug-induced depression of gamma efferent activity. II. Central action of nicotine.
Topics: Animals; Atropine; Cats; Cerebral Ventricles; Chlorpromazine; Choline; Depression, Chemical; Female; Hexamethonium Compounds; Injections, Intravenous; Male; Mecamylamine; Neurons; Neurons, Efferent; Nicotine; Vagotomy | 1970 |
The effects of nicotine and other drugs on the release of injected 3H-norepinephrine and on endogenous norepinephrine levels in the rat brain.
Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Carnitine; Histamine; Male; Mecamylamine; Nicotine; Norepinephrine; Rats; Serotonin; Tritium; Tubocurarine | 1967 |
The acute toxicity, pressor effect, and some central actions of nicotine and related compounds.
Topics: Animals; Arteries; Blood Pressure; Blood Pressure Determination; Cats; Diuresis; Drug Synergism; Injections, Intravenous; Injections, Subcutaneous; Male; Mecamylamine; Methods; Mice; Motor Activity; Nicotine; Nictitating Membrane; Pentobarbital; Rabbits; Rats; Sodium; Time Factors; Water | 1967 |
In vivo release of catecholamines from the adrenal medulla by selective activation of cholinergic receptors.
Topics: Acetylcholine; Adrenal Medulla; Animals; Atropine; Dogs; Epinephrine; Female; Iodides; Male; Mecamylamine; Methacholine Compounds; Nicotine; Norepinephrine; Piperazines; Receptors, Drug | 1968 |
Effect of cholinergic and anticholingeric drugs on a new neuromuscular preparation of the chick.
Topics: Acetylcholine; Animals; Carbachol; Chickens; Decamethonium Compounds; Hexamethonium Compounds; In Vitro Techniques; Male; Mecamylamine; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Nicotine; Parasympatholytics; Parasympathomimetics; Piperazines; Pyrrolidines; Quaternary Ammonium Compounds; Succinylcholine; Tetraethylammonium Compounds; Tubocurarine; Vincristine | 1968 |
Influence of some cholinomimetic and cholinolytic drugs on halothane shivering in mice.
Topics: Anesthesia, Inhalation; Animals; Atropine; Body Temperature Regulation; Drug Synergism; Halothane; Hexamethonium Compounds; Mecamylamine; Methane; Methoxyflurane; Mice; Morphine; Nicotine; Nicotinic Acids; Parasympatholytics; Parasympathomimetics; Physostigmine; Temperature; Time Factors | 1968 |
Cholinergic mechanisms in the cerebellar cortex.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Animals; Atropine; Carbachol; Cats; Cerebral Cortex; Choline; Electric Stimulation; Gallamine Triethiodide; Glutamates; Hexamethonium Compounds; Indoles; Mecamylamine; Methacholine Compounds; Neurons; Nicotine; Nicotinic Acids; Physostigmine; Purkinje Cells; Quaternary Ammonium Compounds; Scopolamine; Synapses; Tubocurarine | 1968 |
[Influence of autonomic drugs on the heart rhythmicity of the isolated guinea pig heart].
Topics: Acetylcholine; Animals; Autonomic Agents; Bradykinin; Female; Guinea Pigs; Heart Rate; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Phenoxybenzamine; Propranolol; Reserpine; Serotonin; Tyramine | 1968 |
[vidence for a muscarinic inhibitory mechanism in the cerebral cortex].
Topics: Acetylcholine; Animals; Atropine; Cats; Cerebral Cortex; Drug Antagonism; Electric Stimulation; Electrophysiology; Female; Male; Mecamylamine; Nicotine; Nicotinic Acids; Parasympathomimetics; Physostigmine; Pilocarpine; Pyrrolidines; Scopolamine; Seizures; Tremorine | 1969 |
Comparison of muscarinic and nicotinic cholinergic agonists on self-stimulation behavior.
Topics: Animals; Hypothalamus; Male; Mecamylamine; Nicotine; Nicotinic Acids; Physostigmine; Quaternary Ammonium Compounds; Rats; Reinforcement, Psychology; Scopolamine; Self Stimulation; Sensory Receptor Cells | 1969 |
The action of acetylcholine on cells in cat cerebellar cortex.
Topics: Acetylcholine; Anesthesia; Animals; Cats; Cerebellar Cortex; Cholinesterase Inhibitors; Electrophysiology; Gallamine Triethiodide; Glutamates; In Vitro Techniques; Mecamylamine; Neurons; Nicotine; Parasympathomimetics; Tubocurarine | 1964 |
Nicotine-induced EEG and behavioral arousal.
Topics: Alkaloids; Animals; Arousal; Behavior, Animal; Cats; Central Nervous System; Electroencephalography; Epinephrine; Histamine; Mecamylamine; Nicotine; Piperazines; Quaternary Ammonium Compounds; Serotonin; Sleep; Vasopressins | 1965 |
The nicotinic effects of choline esters and of nicotine in guinea pig atria.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Female; Guinea Pigs; Heart; Heart Atria; Hexamethonium Compounds; In Vitro Techniques; Male; Mecamylamine; Methacholine Compounds; Muscle Contraction; Nicotine; Reserpine; Tyramine | 1966 |
Effects of mecamylamine on avoidance conditioning and maze learning of mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Learning; Mecamylamine; Mice; Nicotine; Quaternary Ammonium Compounds | 1966 |
Effects of nicotine and some nicotine-like compounds injected into the cerebral ventricles of the cat.
Topics: Acetylcholine; Animals; Brain; Cats; Cerebral Ventricles; Drug Synergism; Hexamethonium Compounds; Mecamylamine; Nicotine; Pempidine; Physostigmine; Piperazines; Respiration; Salivation; Vomiting | 1966 |
Mode of action of vasopressin on isolated proximal colon of the guinea-pig.
Topics: Acetylcholine; Animals; Calcium; Carbachol; Cocaine; Cold Temperature; Colon; Guinea Pigs; Hexamethonium Compounds; Histamine; Hypoxia; In Vitro Techniques; Mecamylamine; Morphine; Muscle Contraction; Nicotine; Pentolinium Tartrate; Procaine; Scopolamine; Serotonin; Tetraethylammonium Compounds; Vasopressins | 1966 |
Cholinergic agonist-antagonist interactions on neocortical and limbic EEG activation.
Topics: Acetylcholine; Amygdala; Animals; Arousal; Atropine; Behavior, Animal; Brain; Cats; Cerebral Cortex; Electroencephalography; Hippocampus; Mecamylamine; Nicotine; Parasympatholytics; Parasympathomimetics; Physostigmine; Pilocarpine; Quaternary Ammonium Compounds; Sleep | 1967 |
Facilitatory effect of nicotine on adrenergic neuroeffector transmission in the isolated ear artery of the rabbit.
Topics: Animals; Arteries; Atropine; Drug Interactions; Ear; Hexamethonium Compounds; In Vitro Techniques; Mecamylamine; Muscle, Smooth, Vascular; Neuroeffector Junction; Nicotine; Rabbits; Regional Blood Flow; Sympathetic Nervous System; Synaptic Transmission; Vasoconstrictor Agents | 1980 |
The effects of nicotine on locomotor activity in non-tolerant and tolerant rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hexamethonium; Hexamethonium Compounds; Humans; Male; Mecamylamine; Motor Activity; Nicotine; Rats; Substance Withdrawal Syndrome | 1983 |
Characteristics of conditioned taste aversion produced by nicotine in rats.
Topics: Amphetamine; Animals; Avoidance Learning; Ganglionic Blockers; Male; Mecamylamine; Nicotine; Rats; Taste | 1983 |
Cholinergic drugs and 4-aminopyridine alter hypoxic-induced behavioral deficits.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Arecoline; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Drug Interactions; Hexamethonium; Hexamethonium Compounds; Hypoxia; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Parasympathomimetics; Physostigmine; Structure-Activity Relationship | 1983 |
Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms.
Topics: Alkaloids; Animals; Azocines; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Hexamethonium; Hexamethonium Compounds; Injections, Intraventricular; Male; Mecamylamine; Metergoline; Nicotine; Parasympatholytics; Quinolizines; Rats; Serotonin Antagonists | 1983 |
Differential effects of mecamylamine on the nicotine induced changes in amine levels and turnover in hypothalamic dopamine and noradrenaline nerve terminal systems and in the secretion of adenohypophyseal hormones in the castrated female rat. Evidence for
Topics: Animals; Castration; Corticosterone; Dopamine; Female; Hypothalamus; Mecamylamine; Methyltyrosines; Nerve Endings; Nicotine; Norepinephrine; Pituitary Hormones, Anterior; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Nicotinic; Tyrosine 3-Monooxygenase | 1984 |
Influence of mecamylamine and atropine on tolerance development to nicotine hypothermia in rats.
Topics: Animals; Atropine; Body Temperature; Drug Tolerance; Female; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains | 1984 |
Effect of agonists and antagonists of cholinergic neurotransmission on growth hormone release in the dog.
Topics: Animals; Blood-Brain Barrier; Butylscopolammonium Bromide; Dogs; Dose-Response Relationship, Drug; Female; Growth Hormone; Male; Mecamylamine; Nicotine; Oxotremorine; Physostigmine; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission | 1983 |
An analysis of nicotinic and opioid processes in the medulla oblongata and nucleus ambiguus of the dog.
Topics: Animals; Blood Pressure; Cyclazocine; Decerebrate State; Dogs; Electric Stimulation; Endorphins; Ethylketocyclazocine; Female; Fentanyl; Heart Rate; Male; Mecamylamine; Medulla Oblongata; Naloxone; Nicotine; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1983 |
Nicotine does not improve discrimination of brain stimulation reward by rats.
Topics: Animals; Brain; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Mecamylamine; Nicotine; Rats; Self Stimulation; Substance Withdrawal Syndrome; Time Factors | 1983 |
Rapid physiologic effects of nicotine in humans and selective blockade of behavioral effects by mecamylamine.
Topics: Behavior; Electromyography; Humans; Male; Mecamylamine; Nicotine; Pupil; Skin Temperature; Smoking; Time Factors | 1983 |
Clinical evaluation of mecamylamine for withdrawal from nicotine dependence.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Mecamylamine; Middle Aged; Nicotine; Smoking; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Role of training dose in discrimination of nicotine and related compounds by rats.
Topics: Alkaloids; Anabasine; Animals; Apomorphine; Azocines; Chlordiazepoxide; Cocaine; Discrimination, Psychological; Ganglionic Stimulants; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Oxotremorine; Picrotoxin; Quinolizines; Quipazine; Rats | 1984 |
Withdrawal from nicotine dependence using mecamylamine: comparison of three-week and six-week dosage schedules.
Topics: Adult; Drug Administration Schedule; Humans; Mecamylamine; Middle Aged; Nicotine; Smoking; Substance-Related Disorders | 1984 |
Nicotine-induced taste aversion: characterization and preexposure effects in rats.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Saccharin; Taste | 1984 |
Cholinoceptive properties of respiratory neurones in the rat medulla.
Topics: Acetylcholine; Animals; Atropine; Male; Mecamylamine; Medulla Oblongata; Muscarine; Neurons; Nicotine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Respiratory Center; Sodium Glutamate | 1983 |
Characterization of the locomotor stimulant action of nicotine in tolerant rats.
Topics: Animals; Chlorisondamine; Drug Tolerance; Male; Mecamylamine; Motor Activity; Nicotine; Rats; Stereoisomerism | 1983 |
Control of behavior by intravenous nicotine injections in laboratory animals.
Topics: Animals; Behavior, Animal; Cocaine; Dogs; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Mecamylamine; Nicotine; Reinforcement Schedule; Saimiri; Smoking; Species Specificity | 1983 |
Nicotine potentiates sodium pentobarbital but not ethanol induced sleep.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Pentobarbital; Receptors, Nicotinic; Sleep; Time Factors | 1983 |
Maintenance of behavior by postponement of scheduled injections of nicotine in squirrel monkeys.
Topics: Animals; Behavior, Animal; Brain; Electroshock; Hexamethonium Compounds; Humans; Injections, Intravenous; Male; Mecamylamine; Nicotine; Premedication; Saimiri; Substance-Related Disorders | 1983 |
Uptake of [3H]-nicotine and [3H]-noradrenaline by cultured chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cell Membrane; Cells, Cultured; Chromaffin System; Cocaine; Imipramine; Mecamylamine; Nicotine; Norepinephrine; Tetracaine | 1984 |
Effects of mecamylamine, nicotine, atropine and physostigmine on the phencyclidine-induced behavioral toxicity.
Topics: Animals; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Phencyclidine; Physostigmine; Seizures | 1984 |
Discriminative stimulus properties of the optical isomers of nicotine.
Topics: Animals; Dose-Response Relationship, Drug; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Prejudice; Rats; Stereoisomerism | 1980 |
Behavioral effects of intraventricularly administered (-)-nicotine on fixed ratio schedules of food presentation in rats.
Topics: Animals; Brain; Conditioning, Operant; Food; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred Strains; Reaction Time | 1982 |
Involvement of cholinergic nicotine-like receptors as modulators of amine turnover in various types of hypothalamic dopamine and noradrenaline nerve terminal systems and of prolactin, LH, FSH and TSH secretion in the castrated male rat.
Topics: Animals; Castration; Catecholamines; Dopamine; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Hypothalamus; Luteinizing Hormone; Male; Mecamylamine; Methyltyrosines; Nicotine; Norepinephrine; Prolactin; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Nicotinic; Thyrotropin | 1982 |
A comparison of nicotine and cocaine self-administration in the dog: fixed-ratio and progressive-ratio schedules of intravenous drug infusion.
Topics: Animals; Body Temperature; Cocaine; Conditioning, Operant; Dogs; Female; Heart Rate; Infusions, Parenteral; Male; Mecamylamine; Nicotine; Pupil; Self Administration | 1983 |
Suppression of behavior by intravenous injections of nicotine or by electric shocks in squirrel monkeys: effects of chlordiazepoxide and mecamylamine.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Drug Interactions; Electroshock; Injections, Intravenous; Male; Mecamylamine; Nicotine; Saimiri; Time Factors | 1983 |
Pharmacodynamic effects of nicotine and acetylcholine biosynthesis in mouse brain.
Topics: Acetylcholine; Animals; Atropine; Biotransformation; Body Temperature; Brain; Choline; Female; Mecamylamine; Mice; Motor Activity; Nicotine; Synaptosomes | 1983 |
Mecamylamine induced blockade of nicotine induced inhibition of gonadotrophin and TSH secretion and of nicotine induced increases of catecholamine turnover in the rat hypothalamus.
Topics: Animals; Castration; Catecholamines; Gonadotropins; Hypothalamus; Male; Mecamylamine; Nicotine; Rats; Thyrotropin | 1980 |
The effect of cholinergic antagonists on a central response to nicotine.
Topics: Animals; Decamethonium Compounds; Hexamethonium Compounds; Humans; Male; Mecamylamine; Movement; Nicotine; Parasympatholytics; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Tubocurarine | 1982 |
Maintenance and suppression of behavior by intravenous nicotine injections in squirrel monkeys.
Topics: Animals; Behavior, Animal; Cebidae; Conditioning, Operant; Injections, Intravenous; Male; Mecamylamine; Nicotine; Reinforcement, Psychology; Saimiri; Self Administration | 1982 |
Hypothalamic catecholamine changes under acute stress occur independently of nicotinic stimulation.
Topics: Animals; Dopamine; Epinephrine; Hexamethonium Compounds; Hypothalamus; Male; Mecamylamine; Nicotine; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Nicotinic; Stress, Physiological | 1982 |
Maintenance of schedule-controlled behavior by intravenous injections of nicotine in squirrel monkeys.
Topics: Animals; Behavior, Animal; Cocaine; Drug Administration Schedule; Injections, Intravenous; Male; Mecamylamine; Nicotine; Saimiri | 1982 |
Suppressive effects of intraperitoneal and intraventricular injections of nicotine on muricide and shock-induced attack on conspecifics.
Topics: Aggression; Animals; Electroshock; Hexamethonium Compounds; Humans; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mecamylamine; Mice; Nicotine; Rats; Vocalization, Animal | 1980 |
Behavioral effects of nicotine: schedule-controlled responding by squirrel monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Dextroamphetamine; Dose-Response Relationship, Drug; Food; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Saimiri | 1981 |
[Effects of mecamylamine and pempidine, secondary and tertiary amines, on the spinal reflex of cats (author's transl)].
Topics: Animals; Cats; Decamethonium Compounds; Depression, Chemical; Female; Male; Mecamylamine; Nicotine; Pempidine; Reflex, Monosynaptic; Spinal Cord; Tetraethylammonium Compounds | 1981 |
Nicotine-induced release of noradrenaline from hypothalamic synaptosomes.
Topics: Animals; Hypothalamus; Male; Mecamylamine; Nicotine; Norepinephrine; Parasympathomimetics; Potassium; Rats; Receptors, Nicotinic; Reserpine; Synaptosomes; Tyramine | 1980 |
Pharmacologic evidence for a tonic muscarinic inhibitory input to the Edinger-Westphal nucleus in the dog.
Topics: Animals; Bethanechol Compounds; Carbachol; Decerebrate State; Dogs; Female; Hexamethonium Compounds; Male; Mecamylamine; Mesencephalon; Microinjections; Nicotine; Oculomotor Nerve; Parasympathetic Nervous System; Physostigmine; Pupil; Sympathetic Nervous System | 1981 |
ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Electrophysiology; Isoxazoles; Male; Mecamylamine; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Time Factors; Ventral Tegmental Area | 1995 |
Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Dopamine; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; Mecamylamine; Microdialysis; N-Methylaspartate; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Nicotinic; Stereoisomerism; Ventral Tegmental Area | 1994 |
Anatoxin-a is a potent agonist of the nicotinic acetylcholine receptor of bovine adrenal chromaffin cells.
Topics: Animals; Bacterial Toxins; Cattle; Cells, Cultured; Chromaffin System; Cyanobacteria Toxins; Epinephrine; Marine Toxins; Mecamylamine; Microcystins; Neurotoxins; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium; Tropanes | 1995 |
Cholinoceptor-mediated effects on glycerol output from human adipose tissue using in situ microdialysis.
Topics: Adipose Tissue; Adult; Atropine; Carbachol; Cholinergic Agents; Female; Glycerol; Humans; Male; Mecamylamine; Microdialysis; Middle Aged; Nicotine; Receptors, Cholinergic; Sympathomimetics | 1995 |
Dissociations between the locomotor stimulant and depressant effects of nicotinic agonists in rats.
Topics: Animals; Dose-Response Relationship, Drug; Locomotion; Male; Mecamylamine; Nicotine; Rats; Time Factors | 1995 |
Nicotine phase-advances the circadian neuronal activity rhythm in rat suprachiasmatic nuclei explants.
Topics: Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Magnesium; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Suprachiasmatic Nucleus; Time Factors | 1995 |
Combined administration of agonist-antagonist as a method of regulating receptor activation.
Topics: Blood Pressure; Humans; Mecamylamine; Nicotine; Receptors, Cholinergic; Smoking | 1995 |
Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Attention; Behavior, Animal; Isoxazoles; Ligands; Lobeline; Mecamylamine; Nicotine; Pyrrolidines; Rats; Receptors, Nicotinic; Time Factors | 1995 |
Involvement of calcium and L-type channels in nicotine-induced antinociception.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesia; Animals; Behavior, Animal; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Injections, Spinal; Intracellular Fluid; Kinetics; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nitrendipine; Nociceptors; Pain Measurement; Rats; Receptors, Nicotinic; Terpenes; Thapsigargin; Tritium | 1993 |
In vivo pharmacological effects of dihydro-beta-erythroidine, a nicotinic antagonist, in mice.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Brain; Dihydro-beta-Erythroidine; Hexamethonium Compounds; In Vitro Techniques; Injections, Spinal; Kinetics; Male; Mecamylamine; Mice; Mice, Inbred ICR; Movement; Nicotine; Nicotinic Antagonists | 1995 |
Concomitant protein phosphorylation and endogenous acetylcholine release induced by nicotine: dependency on neuronal nicotinic receptors and desensitization.
Topics: Acetylcholine; Animals; Atropine; Bungarotoxins; Calcium; Cell Membrane; Ethers, Cyclic; Exocytosis; Frontal Lobe; Male; Mecamylamine; Membrane Potentials; Nerve Tissue Proteins; Nicotine; Nicotinic Antagonists; Okadaic Acid; omega-Agatoxin IVA; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spider Venoms; Synapsins; Synaptosomes; Veratridine | 1994 |
Role of vagal afferents and spinal pathways modulating inhibition of bradykinin-induced plasma extravasation by intrathecal nicotine.
Topics: Afferent Pathways; Animals; Animals, Newborn; Bradykinin; Capillary Permeability; Capsaicin; Injections, Spinal; Knee Joint; Male; Mecamylamine; Medulla Oblongata; Neural Inhibition; Nicotine; Perfusion; Plasma; Rats; Rats, Sprague-Dawley; Spinal Cord; Sympathetic Nervous System; Vagus Nerve; Viscera | 1994 |
Working memory performance and cholinergic effects in the ventral tegmental area and substantia nigra.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Female; Maze Learning; Mecamylamine; Memory; Nicotine; Pilocarpine; Psychomotor Performance; Quinolizines; Rats; Rats, Sprague-Dawley; Scopolamine; Substantia Nigra; Ventral Tegmental Area | 1994 |
Antagonism of nicotine's action by cocaine analogs.
Topics: Animals; Brain; Cattle; Cocaine; Mecamylamine; Mice; Nicotine; Quinuclidinyl Benzilate; Structure-Activity Relationship | 1995 |
Activation of dopamine D1 receptors or alpha 1 adrenoceptors is not involved in the EEG effect of nicotine in rats.
Topics: Animals; Electrodes; Electroencephalography; Injections, Intraperitoneal; Male; Mecamylamine; Motor Activity; Nicotine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Receptors, Nicotinic | 1994 |
Evidence that nicotine can acutely desensitize central nicotinic acetylcholinergic receptors.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Drug Tolerance; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Physostigmine; Rats; Rats, Sprague-Dawley; Scopolamine | 1994 |
Mecamylamine reverses physostigmine-induced attenuation of scopolamine-induced hyperactivity.
Topics: Animals; Hexamethonium; Hyperkinesis; Male; Mecamylamine; Motor Activity; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Physostigmine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine | 1994 |
Benzodiazepine receptor mediation of the anxiolytic-like effect of (-)-nicotine in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Flumazenil; Male; Mecamylamine; Mice; Nicotine; Receptors, GABA-A; Receptors, Nicotinic | 1994 |
The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat.
Topics: Animals; Behavior, Animal; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
Nootropic effect of nicotine on carbon monoxide (CO)-induced delayed amnesia in mice.
Topics: Amnesia; Animals; Avoidance Learning; Carbon Monoxide Poisoning; Electroshock; Male; Mecamylamine; Memory; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nicotinic Antagonists; Nootropic Agents; Receptors, Nicotinic | 1994 |
Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Extracellular Space; Hexamethonium; Homovanillic Acid; Infusion Pumps, Implantable; Limbic System; Male; Mecamylamine; Microdialysis; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley | 1995 |
Nicotine reverses scopolamine-induced impairment of performance in passive avoidance task in rats through its action on the dopaminergic neuronal system.
Topics: Animals; Avoidance Learning; Benzazepines; Dopamine; Dopamine D2 Receptor Antagonists; Male; Mecamylamine; Neurons; Nicotine; Rats; Rats, Wistar; Receptors, Dopamine D1; Scopolamine; Sulpiride | 1994 |
Effect of nicotine, lobeline, and mecamylamine on sensory gating in the rat.
Topics: Acoustic Stimulation; Animals; Dose-Response Relationship, Drug; Lobeline; Male; Mecamylamine; Nicotine; Rats; Reflex, Startle | 1994 |
Preproenkephalin mRNA and methionine-enkephalin content are increased in mouse striatum after treatment with nicotine.
Topics: Animals; Brain; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Protein Precursors; RNA, Messenger; Tissue Distribution | 1995 |
Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Atropine; Bungarotoxins; Cerebral Cortex; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Evoked Potentials; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Mecamylamine; Membrane Potentials; Muscarine; Neurons; Nicotine; Pirenzepine; Pyramidal Tracts; Quinoxalines; Rats; Rats, Sprague-Dawley; Scopolamine; Synaptic Transmission; Tubocurarine | 1993 |
Specific neurophysiological effects of systemic nicotine on neurons in the nucleus accumbens.
Topics: Action Potentials; Animals; Dopamine; Electric Stimulation; Haloperidol; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Morphine; Naloxone; Neurons; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1993 |
Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation.
Topics: Animals; Benzamides; Benzazepines; Clozapine; Corpus Striatum; Dizocilpine Maleate; Gene Expression Regulation; Genes, fos; Glutamates; Glutamic Acid; Male; Mecamylamine; Nicotine; Nucleus Accumbens; Piperazines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Reward | 1994 |
Locomotor activity after nicotine infusions into the fourth ventricle of rats.
Topics: Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Male; Mecamylamine; Motor Activity; Nicotine; Rats | 1994 |
Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension.
Topics: Aconitine; Alkaloids; Animals; Azocines; Blood Pressure; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Injections, Spinal; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spinal Cord; Stereotyped Behavior | 1994 |
Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion.
Topics: Animals; Brain; Bungarotoxins; Drug Tolerance; Female; Mecamylamine; Mice; Mice, Inbred DBA; Nicotine; Receptors, Nicotinic | 1994 |
Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Isoxazoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1994 |
Characteristics of tail-tremor induced by nicotine in rats.
Topics: Animals; Haloperidol; Hexamethonium; Male; Mecamylamine; Motor Activity; Nicotine; Oxotremorine; Rats; Rats, Wistar; Tail; Tremor | 1994 |
Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro.
Topics: Animals; Calcium; Chlorisondamine; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dopamine; Ganglionic Stimulants; In Vitro Techniques; Male; Mecamylamine; Neostriatum; Nicotine; Nicotinic Antagonists; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptosomes | 1994 |
Nicotine-induced antinociception in mice: role of G-proteins and adenylate cyclase.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Animals; Binding, Competitive; Bucladesine; Calcium; Colforsin; Cyclic AMP; GTP-Binding Proteins; Hexamethonium Compounds; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Pain Measurement; Pertussis Toxin; Reaction Time; Virulence Factors, Bordetella | 1994 |
Cardiovascular and behavioral responses to nicotinic agents administered intrathecally.
Topics: Aconitine; Alkaloids; Animals; Atropine; Azocines; Behavior, Animal; Blood Pressure; Bungarotoxins; Cardiovascular System; Dihydro-beta-Erythroidine; Ganglionic Stimulants; Heart Rate; Injections, Spinal; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Nociceptors; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sensitivity and Specificity; Spinal Cord; Trimethaphan | 1994 |
Nicotine-induced activation of locus coeruleus neurons--an analysis of peripheral versus central induction.
Topics: Action Potentials; Animals; Chlorisondamine; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Injections, Intravenous; Locus Coeruleus; Male; Mecamylamine; Neurons; Nicotine; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
Endogenously released DOPA is probably relevant to nicotine-induced increases in locomotor activities of rats.
Topics: alpha-Methyltyrosine; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Injections, Intraventricular; Levodopa; Male; Mecamylamine; Methyltyrosines; Motor Activity; Nerve Fibers; Nicotine; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tyrosine 3-Monooxygenase | 1993 |
Epibatidine is a nicotinic analgesic.
Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Mecamylamine; Mice; Nicotine; Pyridines; Quinolizines; Rats; Receptors, Nicotinic | 1993 |
Effects of central nicotinic cholinergic receptor blockade produced by chlorisondamine on learning and memory performance in rats.
Topics: Animals; Arousal; Avoidance Learning; Brain; Discrimination Learning; Dose-Response Relationship, Drug; Escape Reaction; Exploratory Behavior; Male; Mecamylamine; Mental Recall; Motor Activity; Nicotine; Orientation; Rats; Reaction Time; Receptors, Cholinergic; Receptors, Nicotinic; Retention, Psychology; Social Environment | 1993 |
Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area.
Topics: Acetylglucosamine; Animals; Chromatography, High Pressure Liquid; Dopamine; Extracellular Space; Male; Mecamylamine; Microdialysis; N-Methylaspartate; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Nicotinic; Tetrodotoxin; Ventral Tegmental Area | 1994 |
Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord.
Topics: Afferent Pathways; Analgesics; Animals; Atropine; Blood Pressure; Electric Stimulation; Female; Injections, Intravenous; Injections, Spinal; Male; Mecamylamine; Nerve Fibers; Nicotine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Sural Nerve; Thalamic Nuclei | 1993 |
Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma.
Topics: Carcinoma, Small Cell; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mecamylamine; Nicotine; Serotonin | 1993 |
Multiple binding sites for nicotine receptor antagonists in inhibiting [3H](-)-nicotine binding in rat cortex.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Cholinergic Antagonists; Drug Interactions; Female; In Vitro Techniques; Male; Mecamylamine; Membranes; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar | 1993 |
The discriminative effects of nicotine and their central sites in rats.
Topics: Animals; Discrimination, Psychological; Injections, Intraventricular; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley | 1993 |
Effects of systemic nicotine on serotonin release in rat brain.
Topics: Anesthetics; Animals; Blood Pressure; Frontal Lobe; Male; Mecamylamine; Methoxamine; Microdialysis; Nicotine; Rats; Rats, Sprague-Dawley; Serotonin | 1993 |
Pharmacological consequences of nicotinergic plus serotonergic manipulations.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Receptors, Serotonin; Spatial Behavior | 1993 |
Effects of nicotine on cortical high voltage spindles in rats.
Topics: Action Potentials; Animals; Cerebral Cortex; Cotinine; Dose-Response Relationship, Drug; Electroencephalography; Electrophysiology; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar | 1993 |
Selective administration of nicotine into catecholaminergic regions of rat brainstem stimulates adrenocorticotropin secretion.
Topics: Adrenocorticotropic Hormone; Animals; Brain Stem; Catecholamines; Dose-Response Relationship, Drug; Injections, Intravenous; Injections, Intraventricular; Male; Mecamylamine; Microinjections; Nicotine; Rats; Rats, Inbred Strains | 1993 |
Effects of nicotine on neocortical electrical activity in rats.
Topics: Animals; Brain Diseases; Cerebral Cortex; Cholinergic Fibers; Electroencephalography; Electrophysiology; Male; Mecamylamine; Nicotine; Parasympatholytics; Rats; Rats, Wistar; Substantia Innominata; Tacrine | 1993 |
Acute nicotine injections induce c-fos mostly in non-dopaminergic neurons of the midbrain of the rat.
Topics: Animals; Gene Expression Regulation; Genes, fos; Injections; Male; Mecamylamine; Mesencephalon; Neurons; Nicotine; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1993 |
Cholinergic drugs regulate passive avoidance performance via the amygdala.
Topics: Amygdala; Animals; Arecoline; Avoidance Learning; Behavior, Animal; Brain Diseases; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Parasympathomimetics; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Substantia Innominata | 1993 |
Role of the locus coeruleus in the noradrenergic response to a systemic administration of nicotine.
Topics: Amino Acids; Anesthesia; Animals; Chromatography, High Pressure Liquid; Extracellular Space; Hippocampus; Locus Coeruleus; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Antagonists; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sympathetic Nervous System | 1993 |
Pharmacological nature of soman-induced hypothermia in mice.
Topics: Acetylcholinesterase; Animals; Atropine; Body Temperature; Cholinesterase Inhibitors; Cholinesterase Reactivators; Hypothalamus; Hypothermia; Male; Mecamylamine; Mice; Nicotine; Obidoxime Chloride; Oximes; Oxotremorine; Physostigmine; Pyridinium Compounds; Soman | 1993 |
Nicotine effects on dopamine clearance in rat nucleus accumbens.
Topics: Animals; Dopamine; Electrophysiology; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology | 1996 |
Peripheral nicotine administration increases rubral firing rates in the urethane-anesthetized rat.
Topics: Anesthesia; Animals; Deoxyglucose; Dose-Response Relationship, Drug; Electrophysiology; Glucose; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Red Nucleus; Urethane | 1995 |
Isradipine inhibits nicotine intravenous self-administration in drug-naive mice.
Topics: Animals; Calcium Channel Blockers; Conditioning, Operant; Dose-Response Relationship, Drug; Isradipine; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reinforcement, Psychology; Self Administration | 1995 |
Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation.
Topics: Animals; Brain; Male; Maze Learning; Mecamylamine; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Up-Regulation | 1996 |
The interpeduncular nucleus regulates nicotine's effects on free-field activity.
Topics: Animals; Behavior, Animal; Choline O-Acetyltransferase; Female; Kainic Acid; Mecamylamine; Mesencephalon; Nicotine; Rats; Rats, Sprague-Dawley | 1995 |
Effects of stimulation or blockade of central nicotinic-cholinergic receptors on performance of a novel version of the rat stimulus discrimination task.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Lobeline; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Task Performance and Analysis | 1996 |
Acute and chronic nicotine effects on working memory in aged rats.
Topics: Age Factors; Aging; Animals; Dose-Response Relationship, Drug; Haloperidol; Male; Maze Learning; Mecamylamine; Memory; Nicotine; Rats; Rats, Sprague-Dawley; Scopolamine | 1996 |
Different methods of assessing nicotine-induced antinociception may engage different neural mechanisms.
Topics: Analgesia; Animals; Chlorisondamine; Drug Interactions; Male; Mecamylamine; Neural Pathways; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 1995 |
Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation.
Topics: Acetylcholine; Calcium; Calcium Channels; Cell Differentiation; Electrophysiology; Filaggrin Proteins; Humans; Ion Channel Gating; Ion Channels; Keratinocytes; Mecamylamine; Nicotine; Permeability; Receptors, Nicotinic | 1996 |
Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Female; Mecamylamine; Mice; Mice, Inbred DBA; Nicotine; RNA, Messenger; Up-Regulation | 1996 |
Nicotine cue: lack of effect of the alpha 7 nicotinic receptor antagonist methyllycaconitine.
Topics: Aconitine; Animals; Conditioning, Operant; Cues; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic | 1996 |
Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats.
Topics: Animals; Female; Hippocampus; Maze Learning; Mecamylamine; Memory; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine | 1996 |
Nicotinic autoreceptors mediating enhancement of acetylcholine release become operative in conditions of "impaired" cholinergic presynaptic function.
Topics: Acetylcholine; Animals; Atropine; Calcium; Cerebral Cortex; Choline; In Vitro Techniques; Male; Mecamylamine; Neostigmine; Nicotine; Oxotremorine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Synaptosomes | 1996 |
Nicotine attenuates naloxone-induced jumping behaviour in morphine-dependent mice.
Topics: Animals; Atropine; Behavior, Animal; Benzazepines; Hexamethonium; Male; Mecamylamine; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; Nicotine; Phenoxybenzamine; Propranolol; Substance P; Substance Withdrawal Syndrome; Sulpiride | 1996 |
Ventral tegmental injection of nicotine induces locomotor activity and L-DOPA release from nucleus accumbens.
Topics: Animals; Levodopa; Locomotion; Male; Mecamylamine; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 1996 |
Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rat.
Topics: Animals; Dopamine; Ganglionic Stimulants; Immunohistochemistry; Injections; Male; Mecamylamine; Motor Activity; Nerve Endings; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Tegmentum Mesencephali | 1996 |
Effect of nicotine on the level of extracellular amino acids in the hippocampus of rat.
Topics: Amino Acids; Animals; Extracellular Space; Hippocampus; Injections, Subcutaneous; Kynurenine; Male; Mecamylamine; Microdialysis; Nicotine; Perfusion; Rats; Rats, Sprague-Dawley | 1996 |
Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.
Topics: Acetylcholine; Aconitine; Animals; Calcium; Choline; Dihydro-beta-Erythroidine; Hippocampus; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pempidine; Potassium Chloride; Rats; Receptors, Nicotinic; Synaptosomes | 1996 |
Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells.
Topics: Alkaloids; Allosteric Site; Animals; Azocines; Cells, Cultured; Chickens; Cycloheximide; Fibroblasts; Gene Expression; Kinetics; Macromolecular Substances; Mecamylamine; Mice; Nicotine; Quinolizines; Receptors, Nicotinic; Recombinant Proteins; Tacrine; Transfection; Tubocurarine | 1996 |
Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia.
Topics: Amphetamine; Animals; Behavior, Animal; Brain Diseases; Central Nervous System Stimulants; Disease Models, Animal; Female; Hippocampus; Ibotenic Acid; Male; Maze Learning; Mecamylamine; Memory; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Scopolamine | 1996 |
Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Cholinergic Agonists; Dimethylphenylpiperazinium Iodide; Evoked Potentials; Glutamic Acid; Isoquinolines; Mecamylamine; Neurons; Nicotine; Patch-Clamp Techniques; Quinolizines; Rats; Rats, Wistar; Receptors, Cholinergic; Spinal Cord; Synaptic Transmission; Tetrodotoxin | 1996 |
Mecamylamine-precipitated nicotine-withdrawal aversion in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Drug Evaluation, Preclinical; Evaluation Studies as Topic; Injections, Subcutaneous; Male; Mecamylamine; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1996 |
An oral self-administration model of nicotine preference in rats: effects of mecamylamine.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Self Administration | 1996 |
Tetrodotoxin-sensitivity of nicotine-evoked dopamine release from rat striatum.
Topics: Animals; Cholinergic Agents; Dopamine; Extracellular Space; In Vitro Techniques; Male; Mecamylamine; Microdialysis; Neostriatum; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Synaptosomes; Tetrodotoxin | 1996 |
Acetylcholine elevates intracellular Ca2+ via muscarinic and nicotinic receptors in rat carotid body type I cells.
Topics: Acetylcholine; Animals; Atropine; Calcium; Carotid Body; Cells, Cultured; Cholinergic Agents; Culture Media; Dimethylphenylpiperazinium Iodide; Glossopharyngeal Nerve; Intracellular Fluid; Ion Transport; Mecamylamine; Methacholine Chloride; Muscarine; Muscarinic Antagonists; Nerve Tissue Proteins; Nicotine; Nicotinic Antagonists; Oxotremorine; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Receptors, Presynaptic; Signal Transduction; Species Specificity | 1996 |
Antagonism of AND and AND-OR drug mixture discriminations in rats.
Topics: Animals; Anti-Anxiety Agents; Association Learning; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Flumazenil; GABA Modulators; Mecamylamine; Midazolam; Motivation; Nicotine; Nicotinic Antagonists; Rats; Reinforcement Schedule; Substance-Related Disorders | 1997 |
Preferences for tastes paired with a nicotine antagonist in rats chronically treated with nicotine.
Topics: Animals; Conditioning, Psychological; Fentanyl; Food Preferences; Male; Mecamylamine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Taste | 1997 |
Ethanol depression of cerebellar Purkinje neuron firing involves nicotinic acetylcholine receptors.
Topics: Action Potentials; Animals; Cerebellum; Ethanol; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 1997 |
Effects of monoamine receptor antagonists on nicotine-induced hypophagia in the rat.
Topics: Adrenergic Antagonists; Animals; Anorexia; Atropine; Cholinergic Agents; Cholinergic Antagonists; Dopamine Antagonists; Eating; Hexamethonium; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Neurotransmitter; Serotonin Antagonists | 1997 |
Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Calcium; Corpus Striatum; Dopamine; In Vitro Techniques; Lobeline; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Synaptosomes; Tritium | 1997 |
Differential mechanisms involved in the effect of nicotinic agonists DMPP and lobeline to release [3H]5-HT from rat hippocampal slices.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Hippocampus; In Vitro Techniques; Kinetics; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tritium; Tubocurarine | 1996 |
Nicotinic acetylcholine receptor (nACh-R) agonist-induced changes in brain monoamine turnover in mice.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Dopamine; Isoxazoles; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyrrolidines; Quinolizines; Serotonin; Tacrine | 1997 |
Ibogaine and the dopaminergic response to nicotine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Brain; Dopamine; Dose-Response Relationship, Drug; Drug Tolerance; Homovanillic Acid; Ibogaine; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Presynaptic nicotinic modulation of dopamine release in the three ascending pathways studied by in vivo microdialysis: comparison of naive and chronic nicotine-treated rats.
Topics: Animals; Dopamine; Male; Mecamylamine; Microdialysis; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors | 1997 |
[3H]benzylpempidine, a new radioligand for probing a putative channel site on nicotinic cholinergic receptors.
Topics: Animals; Binding, Competitive; Brain; Calcium; Calcium Channels; Cattle; Cell Membrane; Ligands; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Pempidine; Receptors, Nicotinic; Seizures | 1997 |
Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats.
Topics: Aging; Analysis of Variance; Animals; Cycloserine; Excitatory Amino Acid Antagonists; Male; Maze Learning; Mecamylamine; Nicotine; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reference Values; Space Perception | 1997 |
Adrenocorticotropin response and nicotine-induced norepinephrine secretion in the rat paraventricular nucleus are mediated through brainstem receptors.
Topics: Adrenocorticotropic Hormone; Animals; Brain Stem; Kinetics; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Antagonists; Norepinephrine; Paraventricular Hypothalamic Nucleus; Rats; Receptors, Nicotinic | 1997 |
Contribution of adrenal hormones to nicotine-induced inhibition of synovial plasma extravasation in the rat.
Topics: Adrenal Glands; Animals; Bradykinin; Capillary Permeability; Male; Mecamylamine; Mifepristone; Naloxone; Nicotine; Platelet Activating Factor; Propanolamines; Rats; Rats, Sprague-Dawley | 1997 |
Nicotine self-administration in rats: strain and nicotine pre-exposure effects on acquisition.
Topics: Animals; Conditioning, Operant; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Species Specificity | 1997 |
Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bungarotoxins; Carotid Body; Catecholamines; Catechols; Cats; Chemoreceptor Cells; In Vitro Techniques; Kinetics; Mecamylamine; Neurons; Nicotine; Receptors, Nicotinic; Tritium; Tyrosine | 1997 |
Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats.
Topics: Adrenergic Agents; Adrenergic beta-Antagonists; Animals; Carteolol; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Male; Mecamylamine; Metoprolol; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxidopamine; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta-2; Receptors, Nicotinic; Tail; Tremor | 1997 |
Chronic nicotinic agonist and antagonist effects on T-maze alternation.
Topics: Animals; Female; Maze Learning; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Modulation of apomorphine-induced rotations in unilaterally 6-hydroxydopamine lesioned rats by cholinergic agonists and antagonists.
Topics: Animals; Apomorphine; Atropine; Behavior, Animal; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Oxidopamine; Oxotremorine; Rats; Rats, Wistar; Sulpiride | 1997 |
Is binding to nicotinic acetylcholine and dopamine receptors related to working memory in rats?
Topics: Animals; Dose-Response Relationship, Drug; Maze Learning; Mecamylamine; Memory; Nicotine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Nicotinic | 1997 |
Both nicotinic and muscarinic receptors in ventral tegmental area contribute to brain-stimulation reward.
Topics: Animals; Atropine; Dihydro-beta-Erythroidine; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Reward; Self Stimulation; Ventral Tegmental Area | 1997 |
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.
Topics: Amyloid beta-Peptides; Animals; Benzylidene Compounds; Bungarotoxins; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Hexamethonium; Mecamylamine; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Pyridines; Rats; Receptors, Nicotinic | 1997 |
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Pindolol; Propranolol; Rats; Rats, Wistar; Tail; Tremor | 1997 |
Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine.
Topics: Amyloid beta-Protein Precursor; Animals; Chelating Agents; Culture Media; Egtazic Acid; Kinetics; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; RNA, Messenger | 1997 |
Nicotine induces long-lasting potentiation in the dentate gyrus of nicotine-primed rats.
Topics: Animals; Dentate Gyrus; Male; Mecamylamine; Membrane Potentials; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley | 1997 |
Differential regulation of neocortical synapses by neuromodulators and activity.
Topics: Animals; Baclofen; Cholinergic Fibers; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Mecamylamine; Mice; Mice, Inbred Strains; Muscarinic Agonists; Neocortex; Neurons, Afferent; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organophosphorus Compounds; Pyramidal Cells; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Thalamus | 1997 |
Attenuation of mecamylamine-precipitated nicotine-withdrawal aversion by the 5-HT3 receptor antagonist ondansetron.
Topics: Animals; Conditioning, Psychological; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Substance Withdrawal Syndrome | 1997 |
Nicotinic-receptor mediation of S(-)nornicotine-evoked -3H-overflow from rat striatal slices preloaded with -3H-dopamine.
Topics: Animals; Corpus Striatum; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Tritium | 1997 |
Effects of antimitotic agents on secretion and detergent extractibility of adrenal nicotinic acetylcholine receptors.
Topics: Adrenal Glands; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Catecholamines; Cattle; Cell Division; Cells, Cultured; Chromaffin Cells; Cytoskeleton; Demecolcine; Detergents; Dioxolanes; Diphenylacetic Acids; Mecamylamine; Microtubules; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parasympatholytics; Podophyllotoxin; Receptors, Nicotinic; Vincristine | 1997 |
Acetylcholine increases intracellular calcium of arterial chemoreceptor cells of adult cats.
Topics: Acetylcholine; Animals; Calcium; Carotid Body; Cats; Cells, Cultured; Chemoreceptor Cells; Fluorescent Dyes; Indoles; Kinetics; Mecamylamine; Muscarine; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nifedipine; Pilocarpine; Potassium | 1997 |
Involvement of nitric oxide in development of tail-tremor induced by repeated nicotine administration in rats.
Topics: Animals; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tail; Tremor | 1997 |
Mechanisms of mitogen-activated protein kinase activation by nicotine in small-cell lung carcinoma cells.
Topics: Autocrine Communication; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Small Cell; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; Lung Neoplasms; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pertussis Toxin; Protein-Tyrosine Kinases; Receptors, Cholinergic; Virulence Factors, Bordetella | 1997 |
Nicotine-induced decreases in VTA electrical self-stimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron.
Topics: Animals; Conditioning, Operant; Dopamine Antagonists; Haloperidol; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ondansetron; Rats; Rats, Sprague-Dawley; Scopolamine; Self Stimulation; Serotonin Antagonists; Ventral Tegmental Area | 1997 |
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Ligands; Mecamylamine; Morphine; Nerve Fibers; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Receptors, Nicotinic; Spinal Cord; Substance Withdrawal Syndrome; Synaptic Transmission | 1998 |
Effects of nicotine and footshock stress on dopamine release in the striatum and nucleus accumbens.
Topics: Animals; Chromatography, High Pressure Liquid; Dopamine; Electroshock; Emotions; Male; Mecamylamine; Microdialysis; Motor Activity; Neostriatum; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Stress, Psychological | 1998 |
Use-dependent suppression of the nicotinic acetylcholine receptor response by the proadrenomedullin N-terminal 20-amino acid peptide in rat locus coeruleus neurons.
Topics: Adrenomedullin; Animals; Atropine; Bungarotoxins; Cells, Cultured; Cytidine; Dimethylphenylpiperazinium Iodide; Female; Locus Coeruleus; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Peptide Fragments; Peptides; Proteins; Rats; Rats, Wistar; Receptors, Nicotinic | 1998 |
Nicotinic acetylcholine receptors of the neuronal type occur in the plasma membrane of sea urchin eggs.
Topics: Acetylcholine; Animals; Atropine; Bungarotoxins; Cell Membrane; Fertilization in Vitro; Hexamethonium; Mecamylamine; Membrane Potentials; Microelectrodes; Microscopy, Fluorescence; Muscarine; Muscarinic Agonists; Nicotine; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Receptors, Nicotinic; Sea Urchins; Sodium | 1997 |
Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1998 |
Mecamylamine inhibits nicotine but not capsaicin irritation on the tongue: psychophysical evidence that nicotine and capsaicin activate separate molecular receptors.
Topics: Adult; Capsaicin; Discrimination, Psychological; Female; Humans; Irritants; Male; Mecamylamine; Nicotine; Receptors, Drug; Receptors, Nicotinic; Tongue | 1998 |
Nicotine increases stress-induced serotonin release by stimulating nicotinic acetylcholine receptor in rat striatum.
Topics: Animals; Brain Chemistry; Corpus Striatum; Electroshock; Male; Mecamylamine; Microdialysis; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Nicotinic; Serotonin; Stress, Physiological | 1998 |
Antidepressantlike effects of chronic nicotine on learned helplessness paradigm in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Escape Reaction; Helplessness, Learned; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar | 1998 |
Effect of indomethacin on nicotine-induced ACTH and corticosterone response.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Cyclooxygenase Inhibitors; Hexamethonium; Indomethacin; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar | 1998 |
Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal.
Topics: Animals; Male; Mecamylamine; Naloxone; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
Studies on the role of nicotinic acetylcholine receptors in the discriminative and aversive stimulus properties of ethanol in the rat.
Topics: Animals; Avoidance Learning; Central Nervous System Depressants; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Taste | 1998 |
5-[I-125/123]lodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors.
Topics: Alkaloids; Animals; Azetidines; Azocines; Binding Sites; Brain; Dose-Response Relationship, Drug; Iodine Radioisotopes; Male; Mecamylamine; Mice; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Quinolizines; Radionuclide Imaging; Receptors, Nicotinic; Scopolamine; Tissue Distribution | 1998 |
Pharmacological characterization of nicotinic receptor-mediated acetylcholine release in rat brain--an in vivo microdialysis study.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Brain; Cotinine; Hippocampus; Injections, Intraperitoneal; Ligands; Lobeline; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Quinolizines; Rats; Rats, Inbred F344; Receptors, Nicotinic; Visual Cortex | 1998 |
Mechanisms underlying cerebrovascular effects of cigarette smoking in rats in vivo.
Topics: Animals; Benzoquinones; Blood Glucose; Blood Pressure; Carboxyhemoglobin; Cerebral Arteries; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Heart Rate; Heptanoic Acids; Hypoglycemic Agents; Male; Mecamylamine; Microcirculation; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Propranolol; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Smoking; Vasoconstriction; Vasodilator Agents | 1998 |
Effects of repeated nicotine pre-treatment on mesoprefrontal dopaminergic and behavioral responses to acute footshock stress.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Drug Administration Schedule; Electroshock; Foot; Immobilization; Injections; Male; Mecamylamine; Nicotine; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Physiological | 1998 |
The cholinergic basis of the smoking-induced EEG activation profile.
Topics: Adult; Analysis of Variance; Arousal; Cerebral Cortex; Cholinergic Fibers; Electroencephalography; Humans; Male; Mecamylamine; Middle Aged; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Scopolamine; Sensation; Smoking | 1998 |
Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration.
Topics: Acetylcholine; Alcohol Drinking; Animals; Dopamine; Dose-Response Relationship, Drug; Male; Mecamylamine; Microinjections; Nicotine; Nucleus Accumbens; Rats; Rats, Long-Evans; Receptors, Nicotinic; Reinforcement Schedule; Self Administration; Sucrose | 1998 |
Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons.
Topics: Animals; Animals, Newborn; Calcium; Cell Survival; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamic Acid; Hexamethonium; Kinetics; Mecamylamine; Microtubule-Associated Proteins; Neurons; Neurotoxins; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Tubulin | 1998 |
Chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells.
Topics: Animals; Cell Line; Cholinergic Agonists; Cholinergic Antagonists; Humans; Mecamylamine; Nicotine; Receptors, Cholinergic; Transfection; Up-Regulation; Xenopus laevis | 1998 |
Nicotine administration induced changes in the gonadal functions in male rats.
Topics: Analysis of Variance; Animals; Estradiol; Ganglionic Stimulants; Lipid Metabolism; Liver; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Testis; Testosterone; Weight Gain | 1999 |
Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze.
Topics: Animals; Drug Interactions; Female; Maze Learning; Mecamylamine; Memory, Short-Term; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Scopolamine | 1997 |
Effects of nicotine and mecamylamine on rat dorsal raphe neurons.
Topics: Action Potentials; Animals; Electrophysiology; Ganglionic Stimulants; In Vitro Techniques; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Raphe Nuclei; Rats; Rats, Wistar; Serotonin | 1998 |
Both nicotine and mecamylamine block dizocilpine-induced explosive jumping behavior in mice: psychiatric implications.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Schizophrenia | 1998 |
Ontogeny of the diurnal rhythm of tuberoinfundibular dopaminergic neuronal activity in peripubertal female rats: possible involvement of cholinergic and opioidergic systems.
Topics: Animals; Circadian Rhythm; Dopamine; Female; Limbic System; Male; Mecamylamine; Naloxone; Narcotic Antagonists; Neostriatum; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Opioid Peptides; Parasympathetic Nervous System; Prolactin; Rats; Rats, Sprague-Dawley; Sexual Maturation | 1998 |
Receptor systems participating in nicotine-specific effects.
Topics: Amphetamines; Animals; Benzazepines; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
The nitric oxide synthesis inhibitor nitro-L-arginine (L-NNA) attenuates nicotine abstinence syndrome in the rat.
Topics: Animals; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tobacco Use Disorder | 1998 |
Anti-nicotinic properties of anticholinergic antiparkinson drugs.
Topics: Animals; Antiparkinson Agents; Atropine; Brain; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vitro Techniques; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Protein Binding; Rats; Seizures | 1998 |
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists.
Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Hindlimb; Hot Temperature; Injections, Spinal; Lobeline; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Pain; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine; Vocalization, Animal | 1998 |
Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo-cortical transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Animals; Autoradiography; Cerebral Cortex; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Insecticides; Locomotion; Male; Mecamylamine; Microdialysis; Neural Pathways; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reaction Time; Receptors, Nicotinic; Synaptic Transmission; Thalamus; Tritium | 1999 |
Discrimination and self-administration of nicotine by inbred strains of mice.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Psychological; Infusions, Intravenous; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reinforcement Schedule; Self Administration; Species Specificity | 1999 |
Mecamylamine blocks the development of tolerance to nicotine in rats: implications for the mechanisms of tolerance.
Topics: Analgesics; Animals; Behavior, Animal; Drug Tolerance; Eating; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Up-Regulation | 1999 |
Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine.
Topics: Amphetamine; Analysis of Variance; Animals; Caffeine; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Piperazines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Thiazepines | 1999 |
Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo.
Topics: Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Fluorine Radioisotopes; Frontal Lobe; Kinetics; Ligands; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus; Tissue Distribution | 1999 |
Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Substitution; Animals; Atropine; Choline; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Genetic Variation; Humans; Lobeline; Mecamylamine; Membrane Potentials; Muscarinic Antagonists; Mutation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pyridines; Pyrrolidines; Receptors, Nicotinic; Threonine; Tubocurarine; Valine; Xenopus | 1999 |
Nicotinic receptor binding sites in rat primary neuronal cells in culture: characterization and their regulation by chronic nicotine.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Binding, Competitive; Brain Chemistry; Brain Stem; Cells, Cultured; Cerebral Cortex; Dihydro-beta-Erythroidine; Female; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pregnancy; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tritium | 1999 |
Mecamylamine-precipitated nicotine-withdrawal aversion in Lewis and Fischer 344 inbred rat strains.
Topics: Animals; Ganglionic Stimulants; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Inbred F344; Rats, Inbred Lew; Species Specificity; Substance Withdrawal Syndrome | 1999 |
Effect of nicotine on apomorphine-induced licking behaviour in rats.
Topics: Animals; Apomorphine; Atropine; Cholinergic Antagonists; Dopamine Agonists; Drug Interactions; Hexamethonium; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Stereotyped Behavior | 1999 |
Blockade of nicotine self-administration with nicotinic antagonists in rats.
Topics: Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Reinforcement Schedule; Self Administration | 1999 |
Exposure to nicotine enhances acquisition of ethanol drinking by laboratory rats in a limited access paradigm.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic | 1999 |
Adding behavioral therapy to medication for smoking cessation.
Topics: Drug Therapy, Combination; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; Smoking; Smoking Cessation; Smoking Prevention | 1999 |
Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.
Topics: Aging; Alkaloids; Animals; Axons; Azocines; Carbachol; Choline; Excitatory Postsynaptic Potentials; Mecamylamine; Metamorphosis, Biological; Models, Neurological; N-Methylaspartate; Nerve Regeneration; Neurons; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Quinolizines; Receptors, Cholinergic; Receptors, Nicotinic; Superior Colliculi; Vision, Binocular; Visual Pathways; Xenopus laevis | 1999 |
Nicotine phase shifts the 6-sulphatoxymelatonin rhythm and induces c-Fos in the SCN of rats.
Topics: Animals; Biomarkers; Circadian Rhythm; Male; Mecamylamine; Melatonin; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Photic Stimulation; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Suprachiasmatic Nucleus | 1999 |
Modulation of synaptic transmission by nicotine and nicotinic antagonists in hippocampus.
Topics: Aconitine; Animals; Dihydro-beta-Erythroidine; Hippocampus; In Vitro Techniques; Mecamylamine; Neural Inhibition; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1999 |
Nicotine enhancement of contextual fear conditioning.
Topics: Animals; Association Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Fear; Male; Mecamylamine; Mental Recall; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 1999 |
Effect of nicotine on type 2 deiodinase activity in cultured rat glial cells.
Topics: Animals; Animals, Newborn; Brain; Cells, Cultured; Dithiothreitol; Iodide Peroxidase; Iodine Radioisotopes; Iodothyronine Deiodinase Type II; Mecamylamine; Neuroglia; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Triiodothyronine, Reverse | 1999 |
Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Mecamylamine; Membrane Proteins; Mice; Molecular Sequence Data; Muscles; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Point Mutation; Rats; Receptors, Nicotinic; Sensitivity and Specificity; Sequence Homology, Amino Acid; Xenopus | 1999 |
Pharmacological characterization of nicotine-induced acetylcholine release in the rat hippocampus in vivo: evidence for a permissive dopamine synapse.
Topics: Acetylcholine; Animals; Benzazepines; Dihydro-beta-Erythroidine; Dopamine Antagonists; Dose-Response Relationship, Drug; Hippocampus; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Synapses | 1999 |
Nicotine blocks quinpirole-induced behavior in rats: psychiatric implications.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Bungarotoxins; Dopamine Agonists; Female; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Quinolizines; Quinpirole; Rats; Receptors, Nicotinic; Schizophrenia; Yawning | 1999 |
Changes in sleep after acute and repeated administration of nicotine in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Sleep; Sleep, REM | 1999 |
Nicotine-induced hyperlocomotion is not modified by the estrous cycle, ovariectomy and estradiol replacement at physiological level.
Topics: Animals; Anti-Dyskinesia Agents; Estradiol; Estrus; Female; Ganglionic Stimulants; Haloperidol; Mecamylamine; Motor Activity; Nicotine; Nicotinic Antagonists; Ovariectomy; Ovary; Rats; Rats, Wistar | 1999 |
Acute and chronic nicotine exposure differentially facilitate the induction of LTP.
Topics: Action Potentials; Animals; Cognition; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organ Culture Techniques; Rats; Receptors, Nicotinic | 1999 |
Selective c-fos induction and decreased dopamine release in the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome.
Topics: Amygdala; Animals; Behavior, Animal; Biological Transport; Brain Chemistry; Dopamine; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2000 |
Stimulation of nicotinic receptors in the lateral septal nucleus increases anxiety.
Topics: Animals; Anxiety; Brain Mapping; Dose-Response Relationship, Drug; Male; Maze Learning; Mecamylamine; Microinjections; Nicotine; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Septum Pellucidum; Social Behavior | 1999 |
Nicotine self-administration in rats on a progressive ratio schedule of reinforcement.
Topics: Animals; Extinction, Psychological; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Self Administration | 1999 |
Induction of pulmonary cytochrome P4501A1: interactive effects of nicotine and mecamylamine.
Topics: Animals; Cytochrome P-450 CYP1A1; Female; Lung; Mecamylamine; Microsomes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley | 1999 |
Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine.
Topics: Action Potentials; Animals; Azetidines; Histamine; Histamine H1 Antagonists; Hot Temperature; Male; Mecamylamine; Microinjections; Narcotic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Stimulation, Chemical; Tachyphylaxis | 1999 |
Nicotine stimulation of extracellular glutamate levels in the nucleus accumbens: neuropharmacological characterization.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Denervation; Dicarboxylic Acids; Dopamine; Extracellular Space; Glutamic Acid; Haloperidol; Kainic Acid; Kinetics; Male; Mecamylamine; Microdialysis; Neurotransmitter Uptake Inhibitors; Nicotine; Nucleus Accumbens; Oxidopamine; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2000 |
Beta-estradiol attenuate amyloid beta-peptide toxicity via nicotinic receptors.
Topics: Aconitine; Amyloid beta-Peptides; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cell Survival; Cholinesterase Inhibitors; Estradiol; Formazans; Humans; Mecamylamine; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Pyridines; Rats; Receptors, Nicotinic; Tetrazolium Salts; Tumor Cells, Cultured | 1999 |
Nicotine abstinence in the mouse.
Topics: Animals; Behavior, Animal; Body Weight; Injections, Subcutaneous; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Substance Withdrawal Syndrome; Time Factors | 1999 |
Striatal application of nicotine, but not of lobeline, attenuates dopamine release in freely moving rats.
Topics: Aconitine; Animals; Cocaine; Corpus Striatum; Dopamine; Kinetics; Lobeline; Male; Mecamylamine; Microdialysis; Nerve Endings; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2000 |
Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats.
Topics: Animals; Binding Sites; Brain; Kainic Acid; Male; Mecamylamine; Neuroprotective Agents; Nicotiana; Nicotine; Plants, Toxic; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Smoke | 2000 |
Evidence for nicotinic acetylcholine receptors on nasal trigeminal nerve endings of the rat.
Topics: Alkaloids; Analysis of Variance; Animals; Cyclohexanones; Dihydro-beta-Erythroidine; Ganglionic Blockers; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Nose; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Nicotinic; Trigeminal Nerve | 2000 |
Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine; Infusion Pumps, Implantable; Male; Mecamylamine; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2000 |
Nicotine-evoked [3H]5-hydroxytryptamine release from rat striatal synaptosomes.
Topics: 4-Aminopyridine; Animals; Corpus Striatum; Dihydro-beta-Erythroidine; Ganglionic Blockers; Ganglionic Stimulants; Hippocampus; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Recombinant Proteins; Serotonin; Synaptosomes; Veratridine; Visual Cortex | 2000 |
Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.
Topics: Animals; Brain; Chlorisondamine; Injections, Intraventricular; Male; Mecamylamine; Naloxone; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2000 |
Involvement of nicotinic receptors in alcohol self-administration.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Self Administration | 2000 |
Nicotinic receptors modulating somatodendritic and terminal dopamine release differ pharmacologically.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Hippocampus; Male; Mecamylamine; Motor Activity; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Synaptosomes; Tetrodotoxin; Tritium | 2000 |
Nicotine in an animal model of attention.
Topics: Animals; Attention; Cognition; Drug Interactions; Female; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Psychomotor Performance; Rats; Reaction Time; Scopolamine | 2000 |
Neurobiological mechanisms by which nicotine mediates different types of anxiety.
Topics: Animals; Anxiety; Hippocampus; Interpersonal Relations; Maze Learning; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Septal Nuclei; Serotonin Antagonists | 2000 |
Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Hot Temperature; Hypertension; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Postural Balance; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Substance-Related Disorders | 2000 |
Nicotinic modulation of [(3)H]D-aspartate outflow from cultured cerebellar granule cells.
Topics: Acetylcholine; Animals; Aspartic Acid; Bungarotoxins; Cells, Cultured; Cerebellum; Electric Stimulation; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Rats; Tritium | 2000 |
Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents.
Topics: Adrenergic alpha-Agonists; Amnesia; Animals; Avoidance Learning; Baclofen; Clonidine; Dose-Response Relationship, Drug; Drug Design; GABA Agonists; Mecamylamine; Mice; Molecular Structure; Muscarinic Antagonists; Nicotine; Nootropic Agents; Piperazines; Piracetam; Pyrroles; Scopolamine | 2000 |
Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia.
Topics: Acetylcholine; Acetylcholinesterase; Antibodies; Carbachol; Cell Adhesion; Cell Movement; Cells, Cultured; Choline O-Acetyltransferase; Cholinergic Agonists; Cholinesterase Inhibitors; Epithelial Cells; Esophagus; Fluorescent Antibody Technique, Indirect; Gingiva; Humans; Keratinocytes; Mecamylamine; Mucous Membrane; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polymerase Chain Reaction; Receptors, Nicotinic; RNA, Messenger | 2000 |
Depressive characteristics of FSL rats: involvement of central nicotinic receptors.
Topics: Alkaloids; Animals; Antidepressive Agents; Azocines; Depression; Male; Mecamylamine; Nicotine; Quinolizines; Rats; Receptors, Nicotinic | 2000 |
Nicotine induces disinhibitory behavior in the rat after subchronic peripheral nicotinic acetylcholine receptor blockade.
Topics: Animals; Behavior, Animal; Hexamethonium; Male; Maze Learning; Mecamylamine; Motor Activity; Nicotine; Nicotinic Antagonists; Peripheral Nervous System; Rats; Rats, Wistar; Receptors, Nicotinic | 2000 |
Mecamylamine prevents tolerance but enhances whole brain [3H]epibatidine binding in response to repeated nicotine administration in rats.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Tolerance; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2000 |
Role of neuronal nicotinic-acetylcholine receptors in the activation of neurons in trigeminal subnucleus caudalis by nicotine delivered to the oral mucosa.
Topics: Administration, Oral; Animals; Atropine; Male; Mecamylamine; Mouth Mucosa; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tachyphylaxis; Tongue; Trigeminal Caudal Nucleus | 2000 |
Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthesia; Animals; Blood Pressure; Bungarotoxins; Calcium Channel Blockers; Conotoxins; Excitatory Amino Acid Antagonists; Glutamine; Heart Rate; Hexamethonium; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Solitary Nucleus | 2000 |
Nicotine-induced excitation of midbrain dopamine neurons in vitro involves ionotropic glutamate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Animals; Dihydro-beta-Erythroidine; Dopamine; In Vitro Techniques; Insecticides; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 2000 |
Modulation of opioidergic system on mecamylamine-precipitated nicotine-withdrawal aversion in rats.
Topics: Analgesics; Animals; Male; Mecamylamine; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Antagonists; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Substance Withdrawal Syndrome | 2000 |
Nicotine potentiates sulpiride-induced catalepsy in mice.
Topics: Animals; Antipsychotic Agents; Atropine; Catalepsy; Dose-Response Relationship, Drug; Drug Synergism; Hexamethonium; Male; Mecamylamine; Mice; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Sulpiride | 1998 |
Neonatal nicotine administration influences ethanol-induced behaviors.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Drinking; Ethanol; Male; Mecamylamine; Mice; Motor Activity; Nicotine | 2000 |
Effect of nicotine on sniffing induced by dopaminergic receptor stimulation.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Benzazepines; Dopamine Antagonists; Dose-Response Relationship, Drug; Hexamethonium; Humans; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Receptors, Dopamine; Smell; Sulpiride | 2000 |
Simultaneous determination of mecamylamine, nicotine, and cotinine in plasma by gas chromatography-mass spectrometry.
Topics: Cotinine; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reference Standards; Reproducibility of Results; Solutions | 2000 |
Rapid relief of block by mecamylamine of neuronal nicotinic acetylcholine receptors of rat chromaffin cells in vitro: an electrophysiological and modeling study.
Topics: Animals; Cholinergic Antagonists; Chromaffin Cells; Computer Simulation; Drug Interactions; Electrophysiology; In Vitro Techniques; Mecamylamine; Models, Biological; Neurons; Nicotine; Nicotinic Antagonists; Rats; Receptors, Nicotinic | 2000 |
Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Choline; Dentate Gyrus; Long-Term Potentiation; Mecamylamine; Memory; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Receptors, Nicotinic; Synaptic Transmission; Tobacco Use Disorder | 2000 |
Intraaccumbal mecamylamine infusion does not affect dopamine output in the nucleus accumbens of chronically nicotine-treated rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Chronic Disease; Dopamine; Extracellular Space; Homovanillic Acid; Male; Mecamylamine; Microdialysis; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Nicotinic; Substance Withdrawal Syndrome | 2000 |
Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes.
Topics: Animals; Dopamine; In Vitro Techniques; Lobeline; Male; Mecamylamine; Neostriatum; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rubidium Radioisotopes; Stereoisomerism; Synaptosomes; Thalamus | 2000 |
Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro.
Topics: Animals; Animals, Newborn; Culture Techniques; Dose-Response Relationship, Drug; Ethanol; Hippocampus; Mecamylamine; Nervous System Diseases; Nicotine; Propidium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2000 |
Involvement of adrenergic and cholinergic systems in nicotine-induced anxiogenesis in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anxiety; Atropine; Clonidine; Hexamethonium; Male; Mecamylamine; Mice; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha-1; Yohimbine | 2000 |
Mecamylamine but not the alpha7 receptor antagonist alpha-bungarotoxin blocks sensitization to the locomotor stimulant effects of nicotine.
Topics: Animals; Brain; Bungarotoxins; Dose-Response Relationship, Drug; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2000 |
Evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release.
Topics: Animals; Calcium; Calcium Channel Blockers; Carrier Proteins; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Mecamylamine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Paroxetine; Rats; Rats, Inbred Strains; Receptor, Muscarinic M1; Receptors, GABA-A; Receptors, Glutamate; Receptors, Muscarinic; Receptors, Nicotinic; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tetrodotoxin | 2000 |
Cigarette smoke inhalation stimulates dopaminergic neurons in rats.
Topics: Administration, Inhalation; Animals; Brain; Corpus Striatum; Dopamine; Evoked Potentials; Humans; Limbic System; Mecamylamine; Neurons; Nicotine; Rats; Smoke; Smoking; Substantia Nigra; Tobacco Smoke Pollution | 2000 |
Enhancement of haloperidol-induced catalepsy by nicotine: an investigation of possible mechanisms.
Topics: Animals; Catalepsy; Chlorisondamine; Cotinine; Dopamine Antagonists; Drug Synergism; Haloperidol; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley | 2000 |
Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Depression; Dose-Response Relationship, Drug; Imipramine; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2000 |
Mecamylamine increases cigarette smoking in psychiatric patients.
Topics: Adult; Analysis of Variance; Central Nervous System Stimulants; Double-Blind Method; Female; Humans; Male; Mecamylamine; Mental Disorders; Middle Aged; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Smoking; Tobacco Use Disorder | 2000 |
Nicotine improvement of Morris water task performance after fimbria-fornix lesion is blocked by mecamylamine.
Topics: Animals; Brain Mapping; Escape Reaction; Fornix, Brain; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Orientation; Premedication; Rats; Rats, Long-Evans; Synaptic Transmission | 2001 |
Cardiovascular responses to microinjections of nicotine into the caudal ventrolateral medulla of the rat.
Topics: Analysis of Variance; Animals; Blood Pressure; Diastole; Dose-Response Relationship, Drug; Functional Laterality; Heart Rate; Male; Mecamylamine; Medulla Oblongata; Microinjections; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Respiratory Mechanics; Systole; Vagotomy | 2001 |
Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors.
Topics: Animals; Hexamethonium; Individuality; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2001 |
The possible cross-tolerance between morphine- and nicotine-induced hypothermia in mice.
Topics: Animals; Body Temperature; Drug Interactions; Drug Tolerance; Hexamethonium; Hypothermia, Induced; Male; Mecamylamine; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists | 2001 |
Nicotinic acetylcholine receptor ligands differently affect cytochrome oxidase in the Honeybee brain.
Topics: Animals; Bees; Brain; Bungarotoxins; Electron Transport Complex IV; Hexamethonium; Mecamylamine; Mental Recall; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2001 |
Corticosterone selectively attenuates 8-OH-DPAT-mediated hypothermia in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Inflammatory Agents; Body Temperature; Corticosterone; Hypothermia, Induced; Mecamylamine; Mice; Mice, Inbred BALB C; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 2001 |
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; Disease Models, Animal; Drug Combinations; Electric Stimulation; Fluoxetine; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Piperazines; Rats; Rats, Wistar; Reaction Time; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission; Tobacco Use Disorder | 2001 |
Mechanisms underlying regulation of respiratory pattern by nicotine in preBötzinger complex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Periodicity; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Receptors, Muscarinic; Respiratory Center; Tetrodotoxin | 2001 |
Cholinergic modulation of covert attention in the rat.
Topics: Animals; Attention; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parasympathetic Nervous System; Psychomotor Performance; Rats; Rats, Long-Evans; Reaction Time; Receptors, Nicotinic; Space Perception; Visual Perception; Water Deprivation | 2001 |
Presynaptic alpha7-nicotinic acetylcholine receptors mediate nicotine-induced nitric oxidergic neurogenic vasodilation in porcine basilar arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; alpha7 Nicotinic Acetylcholine Receptor; Animals; Basilar Artery; Bungarotoxins; Cells, Cultured; Female; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide; Norepinephrine; Receptors, Nicotinic; Superior Cervical Ganglion; Swine; Vasoconstrictor Agents; Vasodilation | 2001 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological | 2001 |
Nicotinic receptors involved in gastric noradrenaline release evoked by electrical stimulation of the splanchnic nerve in rats.
Topics: Animals; Atropine; Bungarotoxins; Calcium Channel Blockers; Conotoxins; Dihydro-beta-Erythroidine; Diltiazem; Electric Stimulation; Gastric Mucosa; Hexamethonium; In Vitro Techniques; Male; Mecamylamine; Nicotine; Norepinephrine; Rats; Rats, Wistar; Receptors, Nicotinic; Splanchnic Nerves; Stomach | 2001 |
The effects of physostigmine and cholinergic receptor ligands on novelty-induced neophobia.
Topics: Animals; Anxiety; Cerebral Ventricles; Cholinergic Agonists; Cholinesterase Inhibitors; Exploratory Behavior; Gallamine Triethiodide; Injections, Intraventricular; Ligands; Male; Mecamylamine; Microinjections; Motor Activity; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Physostigmine; Pirenzepine; Rats; Rats, Wistar; Receptors, Cholinergic; Scopolamine | 2000 |
Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism.
Topics: Animals; Drug Administration Schedule; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2001 |
Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens.
Topics: Acetylcholine; Animals; Dopamine; Male; Mecamylamine; Microdialysis; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2001 |
Characterization of human alpha4beta2 neuronal nicotinic receptors stably expressed in SH-EP1 cells.
Topics: Alkaloids; Azocines; Binding Sites; Binding, Competitive; Calcium; Cell Line; Fura-2; Humans; Intracellular Membranes; Mecamylamine; Neurons; Nicotine; Osmolar Concentration; Quinolizines; Receptors, Nicotinic; Time Factors; Up-Regulation | 2001 |
Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens.
Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Male; Mecamylamine; Morphine; Narcotics; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2001 |
Nicotine facilitates glycine release in the rat spinal dorsal horn.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Bacterial Toxins; Bicuculline; Bungarotoxins; Calcium; Calcium Channels; Choline; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Marine Toxins; Mecamylamine; Microcystins; Nerve Endings; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Nicotinic; Substantia Gelatinosa; Tetrodotoxin; Tropanes; Valine | 2001 |
Analgesic and toxic effects of neonicotinoid insecticides in mice.
Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Fibroblasts; Imidazoles; Insecticides; Mecamylamine; Mice; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Thiazines; Time Factors | 2001 |
Nicotine induced seizures blocked by mecamylamine and its stereoisomers.
Topics: Animals; Disease Models, Animal; Male; Mecamylamine; Molecular Conformation; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Seizures | 2001 |
Caffeine, nicotine and mecamylamine share stimulus properties in the preexposure conditioned taste aversion procedure.
Topics: Animals; Avoidance Learning; Caffeine; Central Nervous System Stimulants; Conditioning, Psychological; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Taste | 2001 |
Mecamylamine, a nicotinic receptor channel antagonist, affects amylase secretion by isolated pancreatic acinar cells.
Topics: Amylases; Analysis of Variance; Animals; In Vitro Techniques; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Pancreas; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide | 2001 |
A non-alpha7 nicotinic acetylcholine receptor modulates excitatory input to hippocampal CA1 interneurons.
Topics: Acetylcholine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Choline; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Excitatory Postsynaptic Potentials; Hippocampus; Interneurons; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2002 |
Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo.
Topics: Aconitine; Animals; Blotting, Western; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Antagonism; Hippocampus; Infusions, Intravenous; Male; Mecamylamine; Neurons; Nicotine; PC12 Cells; Rats; Rats, Wistar; Receptors, Nicotinic | 2002 |
Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens.
Topics: Animals; Central Nervous System Depressants; Dopamine; Drug Combinations; Ethanol; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Ventral Tegmental Area | 2002 |
Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Association Learning; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Uptake Inhibitors; In Vitro Techniques; Male; Mecamylamine; Motivation; Motor Activity; Neuronal Plasticity; Neurons; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Nicotinic | 2002 |
Modulation of kappa-opioidergic systems on mecamylamine-precipitated nicotine-withdrawal aversion in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Aversive Therapy; Conditioning, Psychological; Male; Mecamylamine; Morphinans; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Spiro Compounds; Substance Withdrawal Syndrome | 2002 |
Drug trace discrimination with nicotine and morphine in rats.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Mental Recall; Morphine; Naloxone; Nicotine; Rats | 2002 |
Open field habituation learning is improved by nicotine and attenuated by mecamylamine administered posttrial into the nucleus accumbens.
Topics: Animals; Basal Ganglia; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Learning; Locomotion; Male; Mecamylamine; Memory; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Time Factors | 2002 |
The role of cholinergic networks of the anterior basal and inferior frontal lobes in the predatory behaviour of Sepia officinalis.
Topics: Animals; Brain; Bungarotoxins; Cholinergic Agonists; Cholinergic Antagonists; Frontal Lobe; Mecamylamine; Microinjections; Mollusca; Nicotine; Predatory Behavior; Receptors, Nicotinic | 2002 |
Nicotine-like discriminative stimulus effects of bupropion in rats.
Topics: Animals; Bupropion; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Long-Evans | 2002 |
Nicotine and bupropion share a similar discriminative stimulus effect.
Topics: Animals; Antidepressive Agents; Bupropion; Central Nervous System Stimulants; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Stimulus; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Smoking Cessation | 2002 |
Intracellular Ca2+ signals evoked by stimulation of nicotinic acetylcholine receptors in SH-SY5Y cells: contribution of voltage-operated Ca2+ channels and Ca2+ stores.
Topics: Aniline Compounds; Calcium; Calcium Channels; Calcium Signaling; Enzyme Inhibitors; Fluorescent Dyes; Humans; Intracellular Fluid; Macrocyclic Compounds; Mecamylamine; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxazoles; Receptors, Nicotinic; Ryanodine; Tumor Cells, Cultured; Xanthenes | 2002 |
Alpha4beta2 nicotinic acetylcholine receptor activation ameliorates impairment of spontaneous alternation behavior in stroke-prone spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervous System Agents; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Hexamethonium; Hypertension; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peripheral Nervous System; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Nicotinic | 2002 |
Isoflurane hyperalgesia is modulated by nicotinic inhibition.
Topics: Animals; Female; Hyperalgesia; Isoflurane; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Recombinant Proteins; Xenopus | 2002 |
Mechanisms of nicotine mediated communication between NGF-differentiated PC12 and HEL cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Differentiation; Cholinergic Agonists; Chromaffin Cells; Ganglia, Sympathetic; Mecamylamine; Membrane Potentials; Muscarinic Antagonists; Nerve Growth Factor; Neurites; Nicotine; Nicotinic Antagonists; PC12 Cells; Presynaptic Terminals; Rats; Reaction Time; Receptors, Nicotinic; Synaptic Transmission | 2002 |
Nicotine withdrawal syndrome: behavioural distress and selective up-regulation of the cyclic AMP pathway in the amygdala.
Topics: Adenylyl Cyclases; Amygdala; Animals; Cyclic AMP; Ganglionic Stimulants; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Signal Transduction; Stress, Psychological; Substance Withdrawal Syndrome; Up-Regulation | 2002 |
Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine.
Topics: Animals; Bupropion; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; In Vitro Techniques; Kinetics; Male; Mecamylamine; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nomifensine; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Symporters | 2002 |
Mecamylamine blocks enhancement of reference memory but not working memory produced by post-training injection of nicotine in rats tested on the radial arm maze.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Maze Learning; Mecamylamine; Memory; Memory, Short-Term; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Long-Evans | 2002 |
(-)6-n-Propylnicotine antagonizes the antinociceptive effects of (-)nicotine.
Topics: Analgesics; Animals; Discrimination, Psychological; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Antagonists; Pain Measurement; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship | 2002 |
Mecamylamine decreases accumbal dopamine output in mice treated chronically with nicotine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mecamylamine; Mice; Microdialysis; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Time Factors | 2002 |
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Hot Temperature; Immersion; Male; Mecamylamine; Mice; Mice, Knockout; Motor Activity; Neural Pathways; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Reaction Time; Receptors, Cannabinoid; Receptors, Drug; Reward; Substance Withdrawal Syndrome | 2002 |
Reboxetine: attenuation of intravenous nicotine self-administration in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Male; Mecamylamine; Morpholines; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reboxetine; Self Administration; Sucrose | 2002 |
Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.
Topics: Adolescent; Adult; Arginine; Calcium; Calcium Channel Blockers; Cerebral Cortex; Dihydro-beta-Erythroidine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Ganglionic Stimulants; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Male; Mecamylamine; Methylene Blue; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Antagonists; Nitrendipine; Nitric Oxide Synthase; Norepinephrine; omega-Conotoxin GVIA; Oxadiazoles; Purinones; Quinoxalines; Tetrodotoxin; Tritium; Tubocurarine | 2002 |
Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Atropine; Brain; Chlorpyrifos; Cholinesterase Inhibitors; Dimethylphenylpiperazinium Iodide; In Vitro Techniques; Insecticides; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2003 |
Sensitization of cortical acetylcholine release by repeated administration of nicotine in rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Mecamylamine; Microdialysis; Motor Activity; Nicotine; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Inbred F344; Time Factors | 2003 |
Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female rats.
Topics: Animals; Attention; Choice Behavior; Conditioning, Operant; Contrast Sensitivity; Dose-Response Relationship, Drug; Female; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Signal Detection, Psychological | 2002 |
Cross-tolerance between morphine- and nicotine-induced conditioned place preference in mice.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Female; Mecamylamine; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Opioid | 2003 |
Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Psychological; Locomotion; Mecamylamine; Mice; Mice, Knockout; Nicotine; Nicotinic Antagonists; Receptors, Opioid, mu; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2002 |
Effects of prolonged nicotinic ligand exposure on function of heterologously expressed, human alpha4beta2- and alpha4beta4-nicotinic acetylcholine receptors.
Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line; Cholinergic Agents; Humans; In Situ Hybridization; Ligands; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Rubidium Radioisotopes | 2003 |
Potentiation of nicotine reward by alcohol.
Topics: Drug Synergism; Ethanol; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; Reward; Smoking | 2002 |
Nicotine trace discrimination in rats with midazolam as a mediating stimulus.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Extinction, Psychological; Male; Mecamylamine; Midazolam; Nicotine; Rats | 2003 |
Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine.
Topics: Animals; Animals, Newborn; Blotting, Western; Caspase 3; Caspases; Cell Cycle Proteins; Dermis; Extracellular Matrix Proteins; Fibroblasts; Humans; Infant, Newborn; Male; Mecamylamine; Mice; Mice, Knockout; Nicotine; Proto-Oncogene Proteins c-bcl-2; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Up-Regulation | 2003 |
SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.
Topics: Animals; Azepines; Behavior, Animal; Body Temperature; Brain; Cardiovascular System; Cells, Cultured; Dextroamphetamine; Discrimination Learning; Drug Interactions; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Mecamylamine; Microdialysis; Motor Activity; Nicotine; Nicotinic Agonists; Oocytes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Self Administration; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Transfection; Xenopus laevis | 2003 |
Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats.
Topics: Acetylcholine; Animals; Cholinergic Agonists; Cocaine; Conditioning, Operant; Discrimination, Psychological; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Flupenthixol; Generalization, Stimulus; Male; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Antagonists; Pilocarpine; Rats; Rats, Sprague-Dawley | 2003 |
Cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors.
Topics: Age Factors; Animals; Attention; Behavior, Animal; Choice Behavior; Cholinesterase Inhibitors; Cognition; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Indans; Lethal Dose 50; Male; Mecamylamine; Memory, Short-Term; Mice; Mice, Inbred C57BL; Motor Activity; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenols; Piperidines; Psychomotor Performance; Pyrrolidines; Reaction Time; Receptors, Nicotinic; Scopolamine; Seizures | 2003 |
Impact of nicotine withdrawal on novelty reward and related behaviors.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drug Interactions; Ganglionic Blockers; Ganglionic Stimulants; Male; Mecamylamine; Motor Activity; Nicotine; Rats; Reaction Time; Reward; Social Environment; Substance Withdrawal Syndrome; Time Factors | 2003 |
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats.
Topics: Animals; Arthus Reaction; Corticosterone; Cycloheximide; Dose-Response Relationship, Drug; Hexamethonium; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Mifepristone; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Paraventricular Hypothalamic Nucleus; Rabbits; Rats; Rats, Wistar; Skin; Time Factors | 2003 |
Muscarinic receptor activities potentiated by desensitization of nicotinic receptors in rat superior cervical ganglia.
Topics: Animals; Cells, Cultured; Electrophysiology; Mecamylamine; Muscarinic Agonists; Neurons; Nicotine; Nicotinic Antagonists; Oxotremorine; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Superior Cervical Ganglion | 2003 |
Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration.
Topics: Animals; Behavior, Animal; Injections, Intravenous; Male; Mecamylamine; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Antagonists; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2003 |
Antisense inhibition of neuronal nicotinic receptors in the tobacco-feeding insect, Manduca sexta.
Topics: Animals; Base Sequence; Bungarotoxins; Cells, Cultured; gamma-Aminobutyric Acid; Gene Expression; Kinetics; Manduca; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Oligonucleotides, Antisense; Patch-Clamp Techniques; Protein Subunits; Receptors, Nicotinic | 2003 |
Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning.
Topics: Animals; Benzylidene Compounds; Blinking; Conditioning, Eyelid; Drug Interactions; Female; Mecamylamine; Memory Disorders; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Pyridines; Rabbits | 2003 |
Characterization of spontaneous and precipitated nicotine withdrawal in the mouse.
Topics: Animals; Disease Models, Animal; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Antagonists; Substance Withdrawal Syndrome; Time Factors; Tobacco Use Disorder | 2003 |
Effects of drugs which depress the peripheral nervous system on the reticular activating system of the cat.
Topics: Acetylcholine; Animals; Atropine; Brain Stem; Cats; Choline; Dihydro-beta-Erythroidine; Humans; Mecamylamine; Nicotine; Peripheral Nervous System; Physostigmine; Scopolamine | 1958 |
Nicotine enhances responding with conditioned reinforcement.
Topics: Animals; Conditioning, Classical; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology | 2004 |
THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Choline; Ganglia; Ganglia, Autonomic; Ganglionic Blockers; Guinea Pigs; Hexamethonium Compounds; Histamine; Ileum; Isoflurophate; Lysergic Acid Diethylamide; Mecamylamine; Muscle, Smooth; Nicotine; Organophosphate Poisoning; Pempidine; Pentolinium Tartrate; Pharmacology; Phenoxybenzamine; Phosphorus; Poisons; Procaine; Receptors, Serotonin; Research; Scopolamine; Serotonin | 1963 |
PREGANGLIONIC AND POSTGANGLIONIC STIMULATION OF THE GUINEA-PIG ISOLATED VAS DEFERENS PREPARATION.
Topics: Acetylcholine; Animals; Atropine; Bretylium Compounds; Dextroamphetamine; Electric Stimulation; Electrophysiology; Ergotamine; Ganglia; Ganglia, Spinal; Ganglionic Blockers; Guanethidine; Guinea Pigs; Hexamethonium Compounds; Humans; Lidocaine; Male; Mecamylamine; Nicotine; Norepinephrine; Pentolinium Tartrate; Pharmacology; Phentolamine; Potassium; Procaine; Research; Scopolamine; Vas Deferens | 1963 |
EFFECT OF NICOTINE ON CARDIAC NECROSIS INDUCED BY CORTICOSTEROID-ELECTROLYTE-STRESS.
Topics: Adrenal Cortex Hormones; Desoxycorticosterone; Dexamethasone; Humans; Mecamylamine; Myocardial Infarction; Myocardium; Necrosis; Nicotine; Pharmacology; Phenelzine; Phosphates; Potassium; Rats; Research; Reserpine; Sodium; Stress, Physiological; Toxicology | 1965 |
Second hand smoke stimulates tumor angiogenesis and growth.
Topics: Animals; Carcinoma, Lewis Lung; Chemokine CCL2; Endothelial Cells; Hydroxymethylglutaryl CoA Reductases; Mecamylamine; Mice; Neovascularization, Pathologic; Nicotine; Pyridines; Receptors, Nicotinic; Tobacco Smoke Pollution; Vascular Endothelial Growth Factor A | 2003 |
Nicotinic receptor modulation of dopamine transporter function in rat striatum and medial prefrontal cortex.
Topics: Animals; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Mecamylamine; Membrane Glycoproteins; Membrane Transport Proteins; Metabolic Clearance Rate; Neostriatum; Nerve Tissue Proteins; Nicotine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Nicotinic | 2004 |
Cardiovascular effects of nicotine, chlorisondamine, and mecamylamine in the pigeon.
Topics: Animals; Blood Pressure; Chlorisondamine; Columbidae; Drug Interactions; Heart Rate; Mecamylamine; Nicotine; Nicotinic Antagonists | 2004 |
Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Prefrontal Cortex; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tetrodotoxin | 2003 |
Mecamylamine reduces nicotine cross-desensitization of trigeminal caudalis neuronal responses to oral chemical irritation.
Topics: Action Potentials; Animals; Drug Tolerance; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pentanoic Acids; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tongue; Trigeminal Caudal Nucleus | 2003 |
Epibatidine induces long-term potentiation (LTP) via activation of alpha4beta2 nicotinic acetylcholine receptors (nAChRs) in vivo in the intact mouse dentate gyrus: both alpha7 and alpha4beta2 nAChRs essential to nicotinic LTP.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Choline; Dentate Gyrus; Drug Synergism; In Vitro Techniques; Long-Term Potentiation; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic | 2003 |
Methyridine (2-[2-methoxyethyl]-pyridine]) and levamisole activate different ACh receptor subtypes in nematode parasites: a new lead for levamisole-resistance.
Topics: Animals; Antinematodal Agents; Ascaris suum; Bephenium Compounds; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Resistance; Indolizines; Isometric Contraction; Larva; Levamisole; Mecamylamine; Membrane Potentials; Muscles; Nicotine; Nicotinic Antagonists; Protein Isoforms; Pyrantel; Pyridines; Receptors, Nicotinic; Spiro Compounds | 2003 |
Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; In Situ Hybridization; Male; Mecamylamine; Mouth Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Nicotinic; Trigeminal Ganglion | 2003 |
Nicotinic acetylcholinergic receptors regulate the intraspinal release of acetylcholine in male rats.
Topics: Acetylcholine; Aconitine; Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Time Factors | 2003 |
Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome.
Topics: Amphetamines; Animals; Donepezil; Drug Synergism; Head Movements; Indans; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Piperidines; Serotonin Receptor Agonists; Tics; Time Factors; Tourette Syndrome | 2003 |
Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.
Topics: Animals; Capsaicin; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Electric Conductivity; Embryo, Mammalian; Humans; Ion Channel Gating; Kidney; Mecamylamine; Membrane Potentials; Neural Inhibition; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sodium Channels; Trigeminal Ganglion | 2004 |
Nicotine enhances contextual fear conditioning and ameliorates ethanol-induced deficits in contextual fear conditioning.
Topics: Animals; Central Nervous System Depressants; Conditioning, Classical; Drug Interactions; Ethanol; Fear; Male; Mecamylamine; Mental Recall; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists | 2003 |
Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Ganglionic Stimulants; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Time Factors; Tobacco Use Disorder | 2004 |
Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells.
Topics: Aconitine; Animals; Cells, Cultured; Central Nervous System Depressants; Cerebellum; Culture Media; Dihydro-beta-Erythroidine; Ethanol; Female; L-Lactate Dehydrogenase; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2003 |
Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chlorpyrifos; Cholinesterase Inhibitors; DNA; Mecamylamine; Nerve Growth Factor; Nerve Tissue Proteins; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleic Acid Synthesis Inhibitors; PC12 Cells; Rats; Receptors, Nicotinic; RNA | 2003 |
Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Survival; Cells, Cultured; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Free Radicals; Hippocampus; Mecamylamine; Mitochondria; Neurons; Neurotoxins; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2004 |
Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells.
Topics: Acetylcholine; Aconitine; Adrenal Cortex; Animals; Cardenolides; Digoxin; Dose-Response Relationship, Drug; Drug Synergism; Hexamethonium; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Physostigmine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Saponins | 2004 |
Intermittent nicotine administration modulates food intake in rats by acting on nicotine receptors localized to the brainstem.
Topics: Animals; Brain Stem; Drug Antagonism; Eating; Feeding Behavior; Ganglionic Stimulants; Injections, Intraventricular; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2004 |
Effects of nicotine and mecamylamine on cognition in rhesus monkeys.
Topics: Animals; Cognition; Learning; Macaca mulatta; Male; Mecamylamine; Memory; Nicotine; Nicotinic Agonists; Psychomotor Performance; Reaction Time | 2004 |
Long-lasting nicotinic modulation of GABAergic synaptic transmission in the rat nucleus accumbens associated with behavioural sensitization to amphetamine.
Topics: Acetylcholine; Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Stimulants; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mecamylamine; Membrane Potentials; Motor Activity; Neural Inhibition; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Wistar; Synaptic Transmission; Time Factors | 2004 |
Nicotine exerts a permissive role on NMDA receptor function in hippocampal noradrenergic terminals.
Topics: Animals; Calcium; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Male; Mecamylamine; N-Methylaspartate; Nerve Endings; Nicotine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 2004 |
Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats.
Topics: Animals; Appetitive Behavior; Choice Behavior; Conditioning, Classical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Administration Schedule; Hexamethonium; Male; Mecamylamine; Naloxone; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reward | 2004 |
Tolerance to pentylentetrazol-induced convulsions and protection of cerebrovascular integrity by chronic nicotine.
Topics: Analysis of Variance; Animals; Blood Pressure; Blood-Brain Barrier; Brain; Capillary Permeability; Cerebrovascular Circulation; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Evans Blue; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Specific Gravity; Time Factors | 2004 |
Nicotine withdrawal in adolescent and adult rats.
Topics: Adolescent; Age Factors; Analysis of Variance; Animals; Blinking; Disease Models, Animal; Drug Administration Schedule; Humans; Infusion Pumps, Implantable; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2004 |
Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzazepines; Blotting, Western; Bungarotoxins; Cyclosporine; Dihydro-beta-Erythroidine; Dizocilpine Maleate; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Models, Neurological; Neostriatum; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphoproteins; Phosphorylation; Raclopride; Receptors, Dopamine D1; Receptors, Dopamine D2; Tetrodotoxin; Threonine | 2004 |
Protective effects of nicotine against glutamate-induced neurotoxicity in PC12 cells.
Topics: Animals; bcl-2-Associated X Protein; Calcium; Genes, bcl-2; Glutamates; Mecamylamine; Nicotine; Nicotinic Antagonists; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, Nicotinic | 2004 |
Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Hot Temperature; Male; Mecamylamine; Mice; Mice, Inbred ICR; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pain Measurement; Reaction Time; Receptors, Nicotinic; Xenopus laevis | 2005 |
Local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine preexposure.
Topics: Animals; Dendrites; Dopamine; Kinetics; Male; Mecamylamine; Microdialysis; Nicotine; Perfusion; Rats; Rats, Long-Evans; Ventral Tegmental Area | 2004 |
The effects of nitric oxide on the acquisition and expression of nicotine-induced conditioned place preference in mice.
Topics: Animals; Arginine; Conditioning, Operant; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mecamylamine; Mice; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Reward; Tobacco Use Disorder; Vasodilator Agents | 2004 |
Intermittent morphine treatment induces a long-lasting increase in cholinergic modulation of GABAergic synapses in nucleus accumbens of adult rats.
Topics: Acetylcholine; Amphetamine; Anesthetics, Local; Animals; Central Nervous System Stimulants; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mecamylamine; Membrane Potentials; Morphine; Narcotics; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Synapses; Tetrodotoxin | 2005 |
Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Grooming; Hyperalgesia; Infusion Pumps, Implantable; Male; Mastication; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nicotine; Pyridines; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tremor | 2004 |
Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Benzoxazines; Brain; Calcium Channel Blockers; Cell Count; Conditioning, Operant; Dronabinol; Drug Administration Schedule; Drug Interactions; Immunohistochemistry; In Vitro Techniques; Male; Mecamylamine; Mice; Morpholines; Motivation; Naloxone; Naphthalenes; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Proto-Oncogene Proteins c-fos; Radioligand Assay; Substance Withdrawal Syndrome | 2004 |
The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals.
Topics: Alkanes; Animals; Bicuculline; Bungarotoxins; Chromatography, High Pressure Liquid; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Indoles; Linoleic Acid; Lysine; Male; Maleimides; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Presynaptic Terminals; Protein Kinase C; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, Nicotinic; Receptors, Presynaptic; Synaptic Transmission; Valine | 2005 |
Intrahippocampal nicotine in alcohol drinking rats--effects on lever-press response.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Extinction, Psychological; Hippocampus; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar | 2005 |
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors.
Topics: Alkaloids; Azocines; Binding, Competitive; Biomarkers; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chromatography, Affinity; Chromatography, Liquid; Dextromethorphan; Mecamylamine; Membranes, Artificial; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic | 2005 |
Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats.
Topics: Animals; Discrimination Learning; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Mecamylamine; Memantine; Nicotine; Nicotinic Antagonists; Pyridines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2005 |
Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene.
Topics: Analgesics; Animals; Conditioning, Classical; Dopamine; Enkephalins; Female; Hot Temperature; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Nicotine; Nucleus Accumbens; Opioid Peptides; Pain Measurement; Pain Threshold; Protein Precursors; Reward; Spatial Behavior; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2005 |
Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Endothelium, Vascular; Female; Hexamethonium; Mecamylamine; Microcirculation; Microscopy, Fluorescence; Nicotine; Nicotinic Antagonists; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2005 |
Modulation of working, short- and long-term memory by nicotinic receptors in the basolateral amygdala in rats.
Topics: Amygdala; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Drug Administration Schedule; Long-Term Potentiation; Male; Mecamylamine; Memory, Short-Term; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Cholinergic; Receptors, Nicotinic; Retention, Psychology | 2005 |
Involvement of the opioid system in the effects induced by nicotine on anxiety-like behaviour in mice.
Topics: Analysis of Variance; Animals; Anxiety Disorders; Behavior, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Maze Learning; Mecamylamine; Mice; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Opioid | 2005 |
Prefrontal cortical modulation of acetylcholine release in posterior parietal cortex.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Atropine; Carbachol; Cholinergic Agonists; Cholinergic Fibers; Dose-Response Relationship, Drug; Drug Combinations; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Mecamylamine; Microdialysis; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Parietal Lobe; Prefrontal Cortex; Quinoxalines; Rats; Rats, Inbred F344 | 2005 |
Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blotting, Western; Carrageenan; Cell Adhesion Molecules; Cell Migration Inhibition; Cholinergic Agents; DNA Primers; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Inflammation; Leukocytes; Mecamylamine; Mice; Mice, Inbred BALB C; Nicotine; Nicotinic Antagonists; Phagocytes; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Shwartzman Phenomenon; Tumor Necrosis Factor-alpha; Vagus Nerve | 2005 |
Increased expression of L-type high voltage-gated calcium channel alpha1 and alpha2/delta subunits in mouse brain after chronic nicotine administration.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Gene Expression; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Subunits; Tritium; Up-Regulation | 2005 |
Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms.
Topics: Adult; Attention; Behavior, Addictive; Cognition; Cognition Disorders; Comorbidity; Female; Humans; Male; Mecamylamine; Memory; Memory Disorders; Neuropsychological Tests; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Schizophrenia; Schizophrenic Psychology; Smoking; Smoking Prevention; Tobacco Use Disorder | 2005 |
Limits of learning enhancements with nicotine in old male rats.
Topics: Age Factors; Analysis of Variance; Animals; Body Weight; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Learning; Male; Maze Learning; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Long-Evans; Spatial Behavior | 2005 |
Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Aspartic Acid; Azetidines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Choline; Cyanobacteria Toxins; Dicarboxylic Acids; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Frontal Lobe; Immunohistochemistry; In Vitro Techniques; Male; Marine Toxins; Mecamylamine; Microcystins; Microscopy, Confocal; Neurotransmitter Uptake Inhibitors; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphopyruvate Hydratase; Potassium Chloride; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium; Tropanes | 2005 |
Dose, duration, and pattern of nicotine administration as determinants of behavioral dependence in rats.
Topics: Animals; Association Learning; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2006 |
Characterization of nicotine's ability to serve as a negative feature in a Pavlovian appetitive conditioning task in rats.
Topics: Amphetamine; Animals; Arecoline; Association Learning; Bupropion; Caffeine; Chlordiazepoxide; Conditioning, Classical; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Hexamethonium; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; Sucrose | 2006 |
Intravenous nicotine self-administration in rats: effects of mecamylamine, hexamethonium and naloxone.
Topics: Animals; Association Learning; Brain; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Hexamethonium; Humans; Infusions, Intravenous; Male; Mecamylamine; Naloxone; Nicotine; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, Nicotinic; Receptors, Opioid; Reinforcement Schedule | 2006 |
Nicotinic receptor involvement in antinociception induced by exposure to cigarette smoke.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mecamylamine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Opioid, mu; Smoking | 2005 |
Effect of vitamin E on memory retention in rats: possible involvement of cholinergic system.
Topics: Animals; Cerebral Ventricles; Conditioning, Operant; Injections, Intraventricular; Male; Mecamylamine; Memory; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parasympathetic Nervous System; Pilocarpine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Vitamin E; Vitamins | 2006 |
Neurosteroids in nicotine and morphine dependence.
Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Antagonists; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2006 |
Bupropion attenuates nicotine abstinence syndrome in the rat.
Topics: Animals; Association Learning; Avoidance Learning; Bupropion; Conditioning, Classical; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Premedication; Rats; Rats, Sprague-Dawley; Social Environment; Substance Withdrawal Syndrome | 2006 |
Reinstatement of nicotine-seeking behavior by drug-associated stimuli after extinction in rats.
Topics: Animals; Association Learning; Cues; Disease Models, Animal; Extinction, Psychological; Male; Mecamylamine; Motivation; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement Schedule; Self Administration; Social Environment; Tobacco Use Disorder | 2006 |
Timing of nicotine effects on learning in zebrafish.
Topics: Animals; Choice Behavior; Discrimination Learning; Dose-Response Relationship, Drug; Mecamylamine; Mental Recall; Nicotine; Nicotinic Antagonists; Orientation; Reaction Time; Retention, Psychology; Zebrafish | 2006 |
Nicotinic modulation of glutamatergic synaptic transmission in region CA3 of the hippocampus.
Topics: Aconitine; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamates; Hippocampus; In Vitro Techniques; Male; Mecamylamine; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission | 2005 |
Dorsal hippocampal muscarinic and nicotinic receptors are involved in mediating morphine reward.
Topics: Analysis of Variance; Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Mecamylamine; Morphine; Motor Activity; Muscarinic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Physostigmine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Reward | 2006 |
Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
Topics: Animals; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Intravenous; Injections, Subcutaneous; Male; Mecamylamine; Motivation; Motor Activity; Nicotine; Nicotinic Antagonists; Picolines; Premedication; Rats; Rats, Sprague-Dawley; Self Administration; Sucrose | 2006 |
Nicotine stimulates adhesion molecular expression via calcium influx and mitogen-activated protein kinases in human endothelial cells.
Topics: Animals; Bungarotoxins; Calcium; Cells, Cultured; E-Selectin; Endothelial Cells; Enzyme Activation; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; MAP Kinase Signaling System; Mecamylamine; Mitogen-Activated Protein Kinases; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Vascular Cell Adhesion Molecule-1 | 2006 |
Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells.
Topics: Acetylation; Cell Nucleus; Chromatin; Dose-Response Relationship, Drug; Gene Expression; Histones; HL-60 Cells; Humans; Immunoblotting; Leukemia, Promyelocytic, Acute; Mecamylamine; Nicotine; Nicotinic Antagonists; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Up-Regulation | 2005 |
Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs.
Topics: Animals; Dopamine; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2005 |
Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Avoidance Learning; Conditioning, Psychological; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Time Factors | 2006 |
Nicotinic and muscarinic reduction of unitary excitatory postsynaptic potentials in sensory cortex; dual intracellular recording in vitro.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Cholinergic Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Magnesium; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 2006 |
In vitro regulation of serotonin transporter activity by protein kinase A and nicotinic acetylcholine receptors in the prefrontal cortex of rats.
Topics: Animals; Atropine; Carbachol; Cholinergic Agonists; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Protein Kinase Inhibitors; Rats; Receptors, Nicotinic; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes; Thionucleotides; Time Factors; Tritium | 2006 |
Nicotinic mechanisms contribute to soman-induced symptoms and lethality.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Behavior, Animal; Chemical Warfare Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Hyperkinesis; Lethal Dose 50; Mecamylamine; Mice; Muscarinic Antagonists; Muscle Rigidity; Nicotine; Nicotinic Antagonists; Poisoning; Scopolamine; Soman; Time Factors; Tremor | 2006 |
Activation of orexin neurons by acute nicotine.
Topics: Animals; Dihydro-beta-Erythroidine; Ganglionic Stimulants; Hypothalamus; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Mecamylamine; Neurons; Neuropeptides; Nicotine; Nicotinic Antagonists; Orexins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2006 |
Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction.
Topics: Age Factors; Animals; Behavior, Animal; Cotinine; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reward; Self Stimulation; Sensory Thresholds; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2006 |
Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure.
Topics: Animals; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Maze Learning; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Statistics, Nonparametric | 2006 |
Suppression of methamphetamine-seeking behavior by nicotinic agonists.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Lidocaine; Male; Mecamylamine; Methamphetamine; Nicotine; Nicotinic Agonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine | 2006 |
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.
Topics: Aconitine; Animals; Arachidonic Acids; Azetidines; Benzamides; Benzoxazines; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Male; Mecamylamine; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Nicotinic | 2006 |
Roles of peripheral and central nicotinic receptors in the micturition reflex in rats.
Topics: Administration, Intravesical; Animals; Capsaicin; Central Nervous System; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Injections, Intraventricular; Injections, Spinal; Mecamylamine; Muscle Contraction; Nerve Fibers, Unmyelinated; Neurons, Afferent; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reflex; Urinary Bladder; Urination | 2006 |
Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating.
Topics: Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Evoked Potentials, Auditory; Hippocampus; Mecamylamine; Mental Processes; Mice; Mice, Inbred DBA; Nicotine; Receptors, Nicotinic; Schizophrenia | 2006 |
Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor.
Topics: Aconitine; Antibodies; Brain-Derived Neurotrophic Factor; Carbazoles; Carbon Isotopes; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Indole Alkaloids; Mecamylamine; Neuroblastoma; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptor, trkB; Thymidine; Time Factors | 2006 |
Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2007 |
Nicotine suppression of gustatory responses of neurons in the nucleus of the solitary tract.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Sensory; Ganglionic Stimulants; Male; Mecamylamine; Neurons, Afferent; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Taste; Tongue | 2006 |
A preliminary study of the effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanisms.
Topics: Acetylcholinesterase; Adult; Double-Blind Method; Female; Ganglionic Stimulants; Habituation, Psychophysiologic; Humans; Male; Mecamylamine; Neural Inhibition; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Schizophrenia; Smoking; Surveys and Questionnaires | 2006 |
Neurochemical and behavioral effects of bupropion and mecamylamine in the presence of nicotine.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Bupropion; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Presynaptic Terminals; Rats; Rats, Inbred F344; Receptors, Nicotinic; Reinforcement, Psychology; Rubidium Radioisotopes; Tobacco Use Disorder | 2006 |
Carotid body chemosensory activity and ventilatory chemoreflexes in cats persist after combined cholinergic-purinergic block.
Topics: Acetylcholine; Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Carotid Body; Cats; Chemoreceptor Cells; Cholinergic Fibers; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Pulmonary Ventilation; Receptors, Cholinergic; Receptors, Purinergic; Reflex; Suramin | 2007 |
Effects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitro.
Topics: Acetylcholine; Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Carotid Body; Cats; Chemoreceptor Cells; Cholinergic Fibers; Dose-Response Relationship, Drug; In Vitro Techniques; Mecamylamine; Nicotine; Nicotinic Antagonists; Receptors, Cholinergic; Receptors, Purinergic; Suramin | 2007 |
alpha7 Nicotinic acetylcholine receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 and -12 production in monocytes.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Humans; Interleukin-12; Interleukin-18; Lipopolysaccharide Receptors; Lipopolysaccharides; Mecamylamine; Monocytes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2006 |
Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats.
Topics: Animals; Circadian Rhythm; Eating; Extinction, Psychological; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2007 |
The role of nicotinic acetylcholine receptors in the primary reinforcing and reinforcement-enhancing effects of nicotine.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Photic Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Self Administration; Tobacco Use Disorder | 2007 |
Strain specificity and cholinergic modulation of visuospatial attention in three inbred mouse strains.
Topics: Animals; Attention; Choice Behavior; Cholinergic Agents; Cholinergic Fibers; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Nicotine; Receptors, Cholinergic; Scopolamine; Serial Learning; Space Perception; Spatial Behavior; Species Specificity | 2007 |
Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Insecticides; Male; Mecamylamine; Metabolic Clearance Rate; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission; Time Factors; Tobacco Use Disorder | 2007 |
Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the alpha7 nicotinic acetylcholine receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Dihydro-beta-Erythroidine; DNA; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Mecamylamine; Neuroprotective Agents; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Seizures; Transcription Factor AP-1 | 2007 |
Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma.
Topics: Acetylcholine; Action Potentials; Animals; Biological Clocks; Brain; Cognition Disorders; Evoked Potentials, Auditory; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Schizophrenia; Synaptic Transmission; Tobacco Use Disorder | 2007 |
'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration.
Topics: Animals; Conditioning, Operant; Food; Infusions, Intravenous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Water | 2007 |
Morphine-induced place preference: involvement of cholinergic receptors of the ventral tegmental area.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mecamylamine; Morphine; Motor Activity; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Physostigmine; Rats; Rats, Wistar; Receptors, Cholinergic; Ventral Tegmental Area | 2007 |
Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide.
Topics: Animals; Arachidonic Acids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pilocarpine; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Muscarinic; Receptors, Nicotinic; Reinforcement, Psychology; Scopolamine | 2007 |
Lobeline, a potential pharmacotherapy for drug addiction, binds to mu opioid receptors and diminishes the effects of opioid receptor agonists.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Dopamine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; In Vitro Techniques; Lobeline; Mecamylamine; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nicotine; Oocytes; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, mu; Xenopus laevis | 2007 |
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.
Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Membrane; Male; Mecamylamine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Nicotine; Nicotinic Antagonists; Pain; Pyridines; Quinolizines; Reaction Time; Receptors, Nicotinic; Spinal Cord | 2007 |
Theta driving both inhibits and potentiates the effects of nicotine on dentate gyrus responses.
Topics: Action Potentials; Animals; Dentate Gyrus; Electric Stimulation; Excitatory Postsynaptic Potentials; Male; Mecamylamine; Neural Inhibition; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley | 2007 |
Acute effects of nicotine on restraint stress-induced anxiety-like behavior, c-Fos expression, and corticosterone release in mice.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Corticosterone; Male; Mecamylamine; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Proto-Oncogene Proteins c-fos; Restraint, Physical; Stress, Physiological | 2007 |
Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia.
Topics: Acetylcholine; Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Drug Therapy, Combination; Estradiol; Female; Mecamylamine; Nicotine; Nicotinic Agonists; Ovariectomy; Rats; Rats, Wistar; Receptors, Nicotinic | 2006 |
Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats.
Topics: Aconitine; Analysis of Variance; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Infusion Pumps; Infusions, Intravenous; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Photic Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement Schedule; Reinforcement, Psychology; Visual Perception | 2007 |
Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Male; Mecamylamine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2008 |
Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation.
Topics: Animals; Cells, Cultured; Dihydro-beta-Erythroidine; Mecamylamine; Mesencephalon; Mice; Nicotine; Receptors, Nicotinic; Thermodynamics; Up-Regulation | 2007 |
Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat.
Topics: Anesthetics, Inhalation; Animals; Arousal; Behavior, Animal; Consciousness; Dose-Response Relationship, Drug; Ganglionic Blockers; Ganglionic Stimulants; Mecamylamine; Methyl Ethers; Microinjections; Nicotine; Rats; Rats, Sprague-Dawley; Reflex, Abnormal; Sevoflurane; Thalamus | 2007 |
Nicotinic and dopamine D2 receptors mediate nicotine-induced changes in ventral tegmental area neurotensin system.
Topics: Animals; Basal Ganglia; Benzazepines; Corpus Striatum; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Neuropeptides; Neurotensin; Nicotine; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Tegmentum Mesencephali | 2007 |
Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal.
Topics: Animals; Antidepressive Agents; Bupropion; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nortriptyline; Rats; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2007 |
High affinity binding of epibatidine to serotonin type 3 receptors.
Topics: Animals; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Humans; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Rats; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists | 2008 |
Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.
Topics: Adenylyl Cyclases; Animals; Antidotes; Antioxidants; Atropine; Brain; Cell Proliferation; Chlorpyrifos; Cholinesterase Inhibitors; DNA; Insecticides; Mecamylamine; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; PC12 Cells; Rats; Theophylline; Vitamin E | 2007 |
Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist (JWH133)-induced antinociception in mice.
Topics: Animals; Cannabinoids; Dose-Response Relationship, Drug; Formaldehyde; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Threshold; Receptor, Cannabinoid, CB2; Receptors, Nicotinic | 2007 |
Repeated administration of nicotine attenuates the development of morphine tolerance and dependence in mice.
Topics: Analgesics, Opioid; Animals; Atropine; Dose-Response Relationship, Drug; Drug Tolerance; Ganglionic Blockers; Hexamethonium Compounds; Male; Mecamylamine; Mice; Morphine; Morphine Dependence; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Substance Withdrawal Syndrome | 2008 |
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.
Topics: Amygdala; Animals; Anxiety; Behavior, Addictive; Behavior, Animal; Corticotropin-Releasing Hormone; Feeding Behavior; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Self Administration; Substance Withdrawal Syndrome | 2007 |
Nicotine and methamphetamine share discriminative stimulus effects.
Topics: Animals; Choice Behavior; Discrimination Learning; Male; Mecamylamine; Methamphetamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Nicotinic; Sodium Chloride | 2008 |
Effects of nitric oxide synthase inhibitors in attenuating nicotine withdrawal in rats.
Topics: Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Mecamylamine; Motor Activity; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2008 |
Spontaneous nicotine withdrawal potentiates the effects of stress in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Behavior, Animal; Dihydro-beta-Erythroidine; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reflex, Startle; Stress, Psychological; Substance Withdrawal Syndrome; Time Factors | 2008 |
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Methionine; Enkephalins; Male; Mecamylamine; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pro-Opiomelanocortin; Protein Precursors; RNA, Messenger | 2008 |
Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo.
Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mecamylamine; Membrane Potentials; Microdialysis; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Perfusion; Picolines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Time Factors; Ventral Tegmental Area; Xenopus laevis | 2008 |
Ethanol state-dependent memory: involvement of dorsal hippocampal muscarinic and nicotinic receptors.
Topics: Animals; Atropine; Avoidance Learning; Central Nervous System Depressants; Cholinesterase Inhibitors; Ethanol; Hippocampus; Male; Mecamylamine; Memory; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Physostigmine; Receptors, Muscarinic; Receptors, Nicotinic | 2008 |
Chronic nicotine stimulation modulates the immune response of mucosal T cells to Th1-dominant pattern via nAChR by upregulation of Th1-specific transcriptional factor.
Topics: Aged; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; GATA3 Transcription Factor; Humans; Male; Mecamylamine; Middle Aged; Mucous Membrane; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; RNA, Messenger; T-Box Domain Proteins; Th1 Cells; Up-Regulation | 2008 |
Role of the cholinergic mechanisms of the ventrolateral preoptic area of the hypothalamus in regulating the state of sleep and waking in pigeons.
Topics: Animals; Arecoline; Benactyzine; Body Temperature Regulation; Cholinergic Agents; Columbidae; Dose-Response Relationship, Drug; Electroencephalography; Female; Male; Mecamylamine; Microinjections; Nicotine; Preoptic Area; Receptors, Muscarinic; Receptors, Nicotinic; Sleep; Wakefulness | 2008 |
Involvement of dorsal hippocampal nicotinic receptors in the effect of morphine on memory retrieval in passive avoidance task.
Topics: Amnesia; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Psychological; Dose-Response Relationship, Drug; Hippocampus; Injections, Subcutaneous; Male; Mecamylamine; Mental Recall; Microinjections; Morphine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reaction Time; Receptors, Nicotinic | 2008 |
Roles of accessory subunits in alpha4beta2(*) nicotinic receptors.
Topics: Acetylcholine; Allosteric Regulation; Antibodies, Monoclonal; Binding Sites; Biotinylation; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Galantamine; Humans; Inhibitory Concentration 50; Kidney; Mecamylamine; Mutation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Radioimmunoassay; Receptors, Nicotinic; Transfection; Up-Regulation | 2008 |
Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.
Topics: Animals; Cells, Cultured; Choroid; Choroidal Neovascularization; Disease Models, Animal; Endothelium, Vascular; Female; Humans; Immunoblotting; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Antagonists; Protein Isoforms; Receptors, Nicotinic; Retinal Vessels; RNA, Messenger | 2008 |
Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortex.
Topics: Acetylcholine; Analysis of Variance; Animals; Choline; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electrochemistry; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Male; Mecamylamine; Neostigmine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Pyridines; Pyrrolidines; Quinoxalines; Rats; Sodium Channel Blockers; Tetrodotoxin; Valine | 2008 |
Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats.
Topics: Aging; Animals; Avoidance Learning; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Nicotinic acetylcholine receptors of the ventral tegmental area are involved in mediating morphine-state-dependent learning.
Topics: Amnesia; Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Morphine; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Ventral Tegmental Area | 2008 |
Decreased brain reward function during nicotine withdrawal in C57BL6 mice: evidence from intracranial self-stimulation (ICSS) studies.
Topics: Animals; Brain; Drug Implants; Electrodes, Implanted; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reward; Self Stimulation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2008 |
Changes in mRNA and protein levels of nicotinic acetylcholine receptors in Diazoxon exposed pC12 cells.
Topics: Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Combinations; Gene Expression; Mecamylamine; Nicotine; Organophosphorus Compounds; PC12 Cells; Rats; Receptors, Nicotinic; RNA, Messenger | 2008 |
DOPA cyclohexyl ester, a DOPA antagonist, blocks the depressor responses elicited by microinjections of nicotine into the nucleus tractus solitarii of rats.
Topics: Animals; Blood Pressure; Carbachol; Cardiovascular System; Cholinergic Agonists; Excitatory Postsynaptic Potentials; Heart Rate; In Vitro Techniques; Levodopa; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Solitary Nucleus | 2008 |
Nicotine effects on learning in zebrafish: the role of dopaminergic systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Catecholamines; Cognition; Conditioning, Operant; Dopamine; Learning; Mecamylamine; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Zebrafish | 2009 |
Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Mecamylamine; Mice; Morpholines; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Reboxetine; Receptors, Nicotinic; Selective Serotonin Reuptake Inhibitors; Serotonin | 2009 |
The effect of levamisole on sheep trachea alone and with trichlorfon combination.
Topics: Acetylcholine; Animals; Bethanechol; Dose-Response Relationship, Drug; Drug Synergism; In Vitro Techniques; Levamisole; Mecamylamine; Nicotine; Sheep, Domestic; Trachea; Trichlorfon | 2008 |
Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Electron Spin Resonance Spectroscopy; Functional Laterality; Galantamine; Gene Expression Regulation; Male; Mecamylamine; Methamphetamine; Motor Activity; Neuroprotective Agents; Nicotine; Nicotinic Antagonists; Parkinsonian Disorders; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger; Rotarod Performance Test; Tyrosine 3-Monooxygenase | 2008 |
Effect of intra-amygdala injection of nicotine and GABA receptor agents on anxiety-like behaviour in rats.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; Male; Maze Learning; Mecamylamine; Motor Activity; Muscimol; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Nicotinic | 2008 |
Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis.
Topics: Alveolar Bone Loss; Animals; Corticosterone; Disease Models, Animal; Disease Susceptibility; Escherichia coli; Injections, Intraperitoneal; Injections, Subcutaneous; Interleukin-10; Lipopolysaccharides; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Periodontitis; Rats; Rats, Inbred F344; Receptors, Nicotinic; Sodium Chloride; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2009 |
Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons.
Topics: Acetylcholine; Aconitine; Action Potentials; Alkaloids; Animals; Azocines; Brain; Choline; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; Gene Expression; Kinetics; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Protein Subunits; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2009 |
Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Chromones; Donepezil; Dose-Response Relationship, Drug; Embryo, Mammalian; Glycogen Synthase Kinase 3; Indans; Indoles; Mecamylamine; Morpholines; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Serine; Sincalide | 2009 |
Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells.
Topics: Acetylcholine; Aconitine; Age Factors; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autocrine Communication; Bronchi; Cells, Cultured; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Genistein; Gestational Age; Lung; Macaca mulatta; Mecamylamine; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Receptors, Nicotinic; Up-Regulation; Vanadates | 2009 |
Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects.
Topics: Animals; Dopamine; Dopamine Antagonists; Electrophysiology; Flupenthixol; Limbic System; Male; Mecamylamine; Microinjections; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Reinforcement, Psychology; Reward; Synaptic Transmission; Ventral Tegmental Area | 2009 |
Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats.
Topics: Animals; Arachidonic Acid; Brain; Dinoprostone; Male; Mecamylamine; Nicotine; Rats; Rats, Inbred F344; Receptors, Nicotinic | 2009 |
Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats.
Topics: Amygdala; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Mood Disorders; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome | 2009 |
Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts.
Topics: Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Gingiva; Humans; Mecamylamine; NF-kappa B; Nicotine; Nicotinic Antagonists; RNA, Messenger; Transcriptional Activation | 2009 |
Nicotine activates TRPM5-dependent and independent taste pathways.
Topics: Animals; Electrodes; Mecamylamine; Mice; Mice, Knockout; Nicotine; Nicotinic Antagonists; Quinine; Rats; Reverse Transcriptase Polymerase Chain Reaction; Taste; TRPM Cation Channels | 2009 |
Acquired appetitive responding to intravenous nicotine reflects a Pavlovian conditioned association.
Topics: Analysis of Variance; Animals; Appetitive Behavior; Association Learning; Conditioning, Classical; Dose-Response Relationship, Drug; Extinction, Psychological; Food Preferences; Injections, Intravenous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley | 2009 |
Nicotine does not enhance discrimination performance in a temporal bisection procedure.
Topics: Animals; Attention; Choice Behavior; Color Perception; Columbidae; Conditioning, Operant; Discrimination Learning; Generalization, Stimulus; Mecamylamine; Nicotine; Reinforcement Schedule; Time Perception | 2009 |
Preconditioning stimuli that augment chromaffin cell secretion.
Topics: Acetylcholine; Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Catecholamines; Cattle; Cells, Cultured; Choline; Chromaffin Cells; Dose-Response Relationship, Drug; Mecamylamine; Methacholine Chloride; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Potassium; Pyridines; Receptors, Muscarinic; Receptors, Nicotinic; Sympathetic Nervous System; Time Factors | 2009 |
The role of the AT4 and cholinergic systems in the Nucleus Basalis Magnocellularis (NBM): effects on spatial memory.
Topics: Acetylcholine; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Basal Nucleus of Meynert; Behavior, Animal; Carbachol; Cholinergic Antagonists; Dose-Response Relationship, Drug; Male; Maze Learning; Mecamylamine; Memory; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Angiotensin; Scopolamine; Spatial Behavior; Time Factors | 2009 |
Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin.
Topics: Animals; Anxiety; beta-Endorphin; Conditioning, Classical; Crosses, Genetic; Exploratory Behavior; Female; Hyperkinesis; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Antagonists; Pain Measurement; Pro-Opiomelanocortin; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2009 |
Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats.
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Smoking; Smoking Prevention; Substance-Related Disorders | 2009 |
Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats.
Topics: Animals; Antibodies, Monoclonal; Brain; Dose-Response Relationship, Drug; Immunization, Passive; Immunoglobulin G; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reward; Self Stimulation; Stereotaxic Techniques; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2009 |
Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Female; Hindlimb Suspension; Male; Mecamylamine; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Sex Factors; Species Specificity; Stress, Psychological | 2009 |
Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis.
Topics: Alveolar Bone Loss; Animals; Corticosterone; Disease Susceptibility; Immunity; Interleukin-10; Lipopolysaccharides; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Periodontal Attachment Loss; Periodontitis; Rats; Rats, Inbred F344; Receptors, Nicotinic; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2009 |
Behavioral and neurotoxic effects of arsenic exposure in zebrafish (Danio rerio, Teleostei: Cyprinidae).
Topics: Animals; Arsenic; Avoidance Learning; Behavior, Animal; Conditioning, Classical; Mecamylamine; Memory; Nicotine; Oxidative Stress; Zebrafish | 2009 |
Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells.
Topics: Analysis of Variance; Annexin A5; Apoptosis; Atropine; Cell Cycle; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Indans; Mecamylamine; Neuroblastoma; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Piperidines; Propidium; Salsoline Alkaloids | 2009 |
The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices.
Topics: Aconitine; Allosteric Regulation; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Picolines; Rats; Rats, Sprague-Dawley; Tritium | 2009 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Indans; Learning Disabilities; Male; Maze Learning; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Antagonists; Physostigmine; Pilocarpine; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Theta Rhythm | 2009 |
Removal of continuous nicotine infusion produces somatic but not behavioral signs of withdrawal in mice.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Infusion Pumps, Implantable; Infusions, Subcutaneous; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reinforcement, Psychology; Substance Withdrawal Syndrome; Time Factors | 2009 |
Differences between nicotine and cocaine-induced conditioned place preferences.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Benzazepines; Cocaine; Conditioning, Classical; Dopamine Antagonists; Dopamine Uptake Inhibitors; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phentolamine; Space Perception | 2010 |
Potentiated startle as a measure of the negative affective consequences of repeated exposure to nicotine in rats.
Topics: Acoustic Stimulation; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reflex, Startle; Time Factors; Tobacco Use Disorder | 2009 |
Nicotine-conditioned place preference induced CREB phosphorylation and Fos expression in the adult rat brain.
Topics: Animals; Brain; Cell Count; Conditioning, Operant; CREB-Binding Protein; Extinction, Psychological; Gene Expression Regulation; Glutamate Decarboxylase; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oncogene Proteins v-fos; Phosphorylation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors; Tyrosine 3-Monooxygenase | 2009 |
Nicotine activates the chemosensory cation channel TRPA1.
Topics: Airway Resistance; Animals; Antipruritics; Biophysics; Calcium; Calcium Channels; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Electric Stimulation; Extracellular Fluid; Humans; Mecamylamine; Membrane Potentials; Menthol; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Plant Oils; Plethysmography, Whole Body; Sensory Receptor Cells; Time Factors; Transfection; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel | 2009 |
Facilitation of intravenous nicotine self-administration in rats by a motivationally neutral sensory stimulus.
Topics: Animals; Conditioning, Operant; Infusions, Intravenous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Noise; Rats; Rats, Long-Evans; Reinforcement Schedule; Reinforcement, Psychology; Self Administration | 2009 |
Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Bupropion; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mecamylamine; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reward; Time Factors | 2009 |
Nicotine withdrawal produces a decrease in extracellular levels of dopamine in the nucleus accumbens that is lower in adolescent versus adult male rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Bicuculline; Dopamine; Extracellular Space; GABA Antagonists; GABA-A Receptor Antagonists; Hydroxyindoleacetic Acid; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, GABA-A; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2010 |
Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine.
Topics: Animals; Conditioning, Psychological; Dextromethorphan; Dihydro-beta-Erythroidine; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2009 |
Inhibition of glycine transporter 1 attenuates nicotine- but not food-induced cue-potentiated reinstatement for a response previously paired with sucrose.
Topics: Analysis of Variance; Animals; Behavior, Addictive; Behavior, Animal; Benzamides; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Extinction, Psychological; Feeding Behavior; Food; Glycine Plasma Membrane Transport Proteins; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Sucrose | 2010 |
Tobacco smoke exposure induces nicotine dependence in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Dentate Gyrus; Dose-Response Relationship, Drug; Hippocampus; Male; Mecamylamine; Motivation; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Self Administration; Tobacco Smoke Pollution; Tobacco Use Disorder; Up-Regulation | 2010 |
Nicotinic receptors in the habenula: importance for memory.
Topics: Analysis of Variance; Animals; Choice Behavior; Dose-Response Relationship, Drug; Female; Habenula; Maze Learning; Mecamylamine; Memory, Short-Term; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spatial Behavior | 2010 |
Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release.
Topics: Animals; Dopamine; Inhibitory Concentration 50; Mecamylamine; Molecular Structure; Nicotine; Nicotinic Antagonists; Piperidines; Rats; Receptors, Nicotinic | 2010 |
Nicotine elicits a developmentally dependent depression in bullfrog neuroventilatory response to CO(2).
Topics: Age Factors; Analysis of Variance; Animals; Brain Stem; Carbon Dioxide; Dose-Response Relationship, Drug; Hypercapnia; Hypoglossal Nerve; In Vitro Techniques; Mecamylamine; Metamorphosis, Biological; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rana catesbeiana; Respiratory Mechanics | 2010 |
Subtype-selective nicotinic agonists enhance olfactory working memory in normal rats: a novel use of the odour span task.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azabicyclo Compounds; Male; Mecamylamine; Memory, Short-Term; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Odorants; Olfactory Perception; Rats; Receptors, Nicotinic; Scopolamine; Thiophenes | 2010 |
Corticosterone urinalysis and nicotinic receptor modulation in rats.
Topics: Animals; Biological Assay; Corticosterone; Dose-Response Relationship, Drug; Male; Mecamylamine; Neuropharmacology; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Nicotinic; Up-Regulation; Urinalysis | 2010 |
Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization.
Topics: Amphetamine; Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Central Nervous System Stimulants; Cocaine; Conotoxins; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Functional Laterality; Levodopa; Male; Mecamylamine; Neostriatum; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereotyped Behavior | 2010 |
Effects of varenicline and mecamylamine on the acquisition, expression, and reinstatement of nicotine-conditioned place preference by drug priming in rats.
Topics: Animals; Benzazepines; Conditioning, Classical; Dose-Response Relationship, Drug; Male; Mecamylamine; Morphine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Tobacco Use Disorder; Varenicline | 2010 |
Nicotinic acetylcholine receptors of the dorsal hippocampus and the basolateral amygdala are involved in ethanol-induced conditioned place preference.
Topics: Amygdala; Animals; CA1 Region, Hippocampal; Conditioning, Classical; Ethanol; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Reward | 2010 |
Nicotine and cocaine self-administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Benzazepines; Cocaine; Conditioning, Operant; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Extinction, Psychological; Food Preferences; Infusions, Intravenous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Sucrose | 2010 |
Varenicline and mecamylamine attenuate locomotor sensitization and cross-sensitization induced by nicotine and morphine in mice.
Topics: Analgesics, Opioid; Animals; Benzazepines; Dose-Response Relationship, Drug; Drug Interactions; Male; Mecamylamine; Mice; Morphine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Varenicline | 2010 |
Emergence of dormant conditioned incentive approach by conditioned withdrawal in nicotine addiction.
Topics: Animals; Behavior, Addictive; Choice Behavior; Conditioning, Psychological; Cues; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Reinforcement, Psychology; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2010 |
Nicotine's enhancing effects on responding maintained by conditioned reinforcers are reduced by pretreatment with mecamylamine, but not hexamethonium, in rats.
Topics: Animals; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Extinction, Psychological; Hexamethonium; Male; Mecamylamine; Motivation; Nicotine; Nicotinic Antagonists; Rats; Rats, Long-Evans; Reinforcement, Psychology | 2010 |
Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Analysis of Variance; Animals; Biological Clocks; Cardiovascular Agents; Colforsin; Cyclic Nucleotide-Gated Cation Channels; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Interneurons; Male; Mecamylamine; Mice; Mice, Transgenic; Models, Biological; Models, Molecular; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Somatostatin | 2010 |
An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Conditioning, Classical; Cyclopentanes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mecamylamine; N-Methylaspartate; Nicotine; Phencyclidine; Phenols; Piperazines; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |
Nicotine modulates gelatinase B (MMP-9) and epilysin (MMP-28) expression in reconstituted human oral epithelium.
Topics: Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelium; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Keratinocytes; Matrix Metalloproteinase 9; Matrix Metalloproteinases, Secreted; Mecamylamine; Mouth Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Kinase C; Smoking; Wound Healing | 2011 |
Spatial working memory impairments induced by cigarette smoking abstinence are correlated with plasma nicotine levels in schizophrenia.
Topics: Humans; Mecamylamine; Memory Disorders; Memory, Short-Term; Neuropsychological Tests; Nicotine; Nicotinic Antagonists; Schizophrenia; Smoking; Smoking Cessation | 2011 |
The effects of nicotine, varenicline, and cytisine on schedule-controlled responding in mice: differences in α4β2 nicotinic receptor activation.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Reinforcement Schedule; Smoking Cessation; Time Factors; Varenicline | 2011 |
Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analysis of Variance; Animals; Atropine; Bicuculline; Cell Count; Cell Size; Dopamine; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Gene Expression Regulation; In Vitro Techniques; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdissection; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Proto-Oncogene Proteins c-fos; Receptors, Nicotinic; RNA, Messenger; Temperature; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2011 |
Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons.
Topics: Analysis of Variance; Animals; Azetidines; Behavior, Animal; Benzazepines; Cerebral Cortex; Conditioning, Classical; Cues; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epigenomics; Exploratory Behavior; Fear; Freezing Reaction, Cataleptic; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Male; Mecamylamine; Methyl-CpG-Binding Protein 2; Mice; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Promoter Regions, Genetic; Quinoxalines; Receptors, Nicotinic; RNA, Messenger; Varenicline | 2011 |
Sexually diergic hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine infusion, and nicotine withdrawal by mecamylamine in rats.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Corticosterone; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Female; Hypothalamo-Hypophyseal System; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pituitary-Adrenal System; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2011 |
The necessity of α4* nicotinic receptors in nicotine-driven behaviors: dissociation between reinforcing and motor effects of nicotine.
Topics: Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Ketamine; Locomotion; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Reinforcement, Psychology; Self Administration | 2011 |
Nicotine-induced impulsive action: sensitization and attenuation by mecamylamine.
Topics: Animals; Dose-Response Relationship, Drug; Impulsive Behavior; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 2011 |
Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung.
Topics: Aldehydes; Animals; Apoptosis; Bungarotoxins; Calcium-Binding Proteins; Calponins; Lung; Mecamylamine; Microfilament Proteins; Nicotine; Nitrosamines; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Smoking; Tobacco Smoke Pollution | 2011 |
Acute nicotine increases both impulsive choice and behavioural disinhibition in rats.
Topics: Animals; Behavior, Animal; Choice Behavior; Conditioning, Operant; Impulsive Behavior; Inhibition, Psychological; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Reinforcement, Psychology | 2011 |
Acetylcholine and norepinephrine mediate GABAergic but not glycinergic transmission enhancement by melittin in adult rat substantia gelatinosa neurons.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Carbachol; Dioxanes; gamma-Aminobutyric Acid; Glycine; Indoles; Inhibitory Postsynaptic Potentials; Male; Mecamylamine; Melitten; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Antagonists; Norepinephrine; Purinergic P2X Receptor Antagonists; Pyridoxal Phosphate; Rats; Serotonin Antagonists; Substantia Gelatinosa; Synaptic Transmission; Tropisetron | 2011 |
Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Caffeine; Calcium Signaling; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Mecamylamine; Microscopy, Fluorescence; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sodium Channel Blockers; Solitary Nucleus; Synaptic Transmission; Temperature; Tetrodotoxin; Time Factors | 2011 |
Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Attention; Buspirone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Exploratory Behavior; Mecamylamine; Neurochemistry; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Space Perception; Time Factors; Zebrafish | 2011 |
Patterns of nicotinic receptor antagonism: nicotine discrimination studies.
Topics: Animals; Benzazepines; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Data Interpretation, Statistical; Dihydro-beta-Erythroidine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Varenicline | 2011 |
Ability of baclofen to prevent somatic manifestations and neurochemical changes during nicotine withdrawal.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Smoking Cessation; Substance Withdrawal Syndrome; Time Factors | 2011 |
Nicotine improves the functional activity of late endothelial progenitor cells via nicotinic acetylcholine receptors.
Topics: Bungarotoxins; Cell Adhesion; Cell Movement; Cell Shape; Cell Survival; Cells, Cultured; Endothelial Cells; Fetal Blood; Humans; Infant, Newborn; Mecamylamine; Neovascularization, Physiologic; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Stem Cells | 2011 |
Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Fructose; Humans; Kainic Acid; Lipid Peroxidation; Male; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Seizures; Topiramate | 2011 |
Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys.
Topics: Animals; Benzazepines; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Macaca mulatta; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Reinforcement, Psychology; Self Administration; Time Factors; Varenicline | 2011 |
Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administration.
Topics: Animals; Behavior, Animal; Brain; Conotoxins; Female; Ibogaine; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, Nicotinic; Self Administration | 2011 |
Involvement of the cholinergic system of CA1 on harmane-induced amnesia in the step-down passive avoidance test.
Topics: Amnesia; Animals; Anxiety; Avoidance Learning; CA1 Region, Hippocampal; Cholinergic Fibers; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Harmine; Male; Mecamylamine; Mental Recall; Mice; Mice, Inbred Strains; Microinjections; Nicotine | 2012 |
Analysis of nicotine-induced DNA damage in cells of the human respiratory tract.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Bronchi; Cell Line; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Humans; In Situ Nick-End Labeling; Mecamylamine; Mutagens; Nasal Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxidative Stress; Respiratory Mucosa | 2012 |
Role of α7- and β4-containing nicotinic acetylcholine receptors in the affective and somatic aspects of nicotine withdrawal: studies in knockout mice.
Topics: Affect; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Drug Implants; Electrodes, Implanted; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Self Stimulation; Substance Withdrawal Syndrome | 2012 |
CREB involvement in the regulation of striatal prodynorphin by nicotine.
Topics: Adenylyl Cyclases; Animals; Benzazepines; Corpus Striatum; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Male; Mecamylamine; Mice; Nicotine; Phosphorylation; Protein Binding; Protein Precursors; Response Elements; Time Factors; Transcription, Genetic | 2012 |
Effect of cholinergic drugs on the activity of basic carboxypeptidases in rat nervous tissue.
Topics: Adrenal Glands; Animals; Arecoline; Atropine; Brain; Carboxypeptidase H; Cholinergic Agents; Enzyme Inhibitors; Male; Mecamylamine; Neuropeptides; Nicotine; Phenylmethylsulfonyl Fluoride; Rats | 2011 |
SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Indoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Mice; Narcotic Antagonists; Nicotine; src-Family Kinases; Substance Withdrawal Syndrome; Sulfonamides; Tobacco Use Disorder | 2012 |
Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells.
Topics: Cell Proliferation; Cells, Cultured; Collagen; Gene Expression; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Mecamylamine; Nicotine; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Protein Kinase C; Receptors, Nicotinic; Smoking; Transforming Growth Factor beta1 | 2012 |
Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.
Topics: Anhedonia; Animals; Brain; Cocaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward; Self Stimulation; Substance Withdrawal Syndrome; Time Factors | 2012 |
Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Amygdala; Animals; Benzenesulfonates; Clonidine; Electrodes, Implanted; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Quinolines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2012 |
ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.
Topics: Adolescent; Adult; Aged; Animals; Coenzyme A Ligases; Environmental Exposure; Female; Gene Expression Regulation; Humans; Male; Mecamylamine; Mice; Middle Aged; Nicotine; Nicotinic Antagonists; Polymorphism, Single Nucleotide; Rats; Receptors, Nicotinic; RNA, Messenger; Schizophrenia; Smoking; Time Factors; Young Adult | 2011 |
Precipitated withdrawal from nicotine reduces reinforcing effects of a visual stimulus for rats.
Topics: Animals; Conditioning, Operant; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Substance Withdrawal Syndrome; Time Factors | 2012 |
Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.
Topics: Animals; Benzazepines; Dose-Response Relationship, Drug; Female; Genotype; Hexamethonium; Hypothermia; Inhibitory Concentration 50; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Motor Activity; Mutation; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ondansetron; Quinoxalines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Varenicline | 2012 |
Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dihydro-beta-Erythroidine; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mecamylamine; Mitochondria; Mitogen-Activated Protein Kinase 1; Nicotine; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Receptors, Cholinergic; RNA Interference; RNA, Small Interfering; Smoking; Transcription, Genetic | 2012 |
Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats.
Topics: Age Factors; Amyloid beta-Protein Precursor; Animals; Corpus Striatum; Hippocampus; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley | 2012 |
Nicotinic acetylcholine receptor α7 and β4 subunits contribute nicotine-induced apoptosis in periodontal ligament stem cells.
Topics: Adult; Apoptosis; Bungarotoxins; Cell Survival; Cells, Cultured; DNA Fragmentation; G1 Phase; Gene Expression; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; Periodontal Ligament; Phosphorylation; Receptors, Nicotinic; Smoking; Stem Cells; Tumor Suppressor Protein p53 | 2012 |
Nicotine-like effects of the neonicotinoid insecticides acetamiprid and imidacloprid on cerebellar neurons from neonatal rats.
Topics: Animals; Animals, Newborn; Brain; Bungarotoxins; Calcium; Cerebellum; Dihydro-beta-Erythroidine; Humans; Imidazoles; Insecticides; Mecamylamine; Neonicotinoids; Neurons; Neurotoxins; Nicotine; Nitro Compounds; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2012 |
Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Cotinine; Humans; Mecamylamine; Nicotine; Sensitivity and Specificity; Smoking; Smoking Cessation; Tandem Mass Spectrometry | 2012 |
Pharmacologic characterization of a nicotine-discriminative stimulus in rhesus monkeys.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Cocaine; Conditioning, Operant; Discrimination Learning; Dopamine Uptake Inhibitors; Drug Interactions; Female; Hypnotics and Sedatives; Macaca mulatta; Male; Mecamylamine; Midazolam; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Varenicline | 2012 |
Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease.
Topics: Animals; Cell Line; Dicumarol; Dopaminergic Neurons; Dose-Response Relationship, Drug; Indolequinones; Mecamylamine; Melanins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parkinson Disease; Rats; Receptors, Nicotinic; Substantia Nigra; Uncoupling Agents | 2012 |
Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Female; Hypothalamus; Male; Mecamylamine; Nicotine; Osmotic Pressure; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stress, Physiological; Substance Withdrawal Syndrome | 2012 |
Low-dose nicotine facilitates spatial memory in ApoE-knockout mice in the radial arm maze.
Topics: Analysis of Variance; Animals; Apolipoproteins E; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Maze Learning; Mecamylamine; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Time Factors | 2013 |
Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice.
Topics: Analysis of Variance; Animals; Brain; Conditioning, Operant; Electric Stimulation; Mecamylamine; Mice; Microelectrodes; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Up-Regulation | 2012 |
Mecamylamine elicits withdrawal-like signs in rats following a single dose of nicotine.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Self Stimulation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
Nicotine-induced enhancement of responding for conditioned reinforcement in rats: role of prior nicotine exposure and α4β2 nicotinic receptors.
Topics: Aconitine; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, Nicotinic; Reinforcement Schedule | 2013 |
Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal.
Topics: Adaptation, Physiological; Age Factors; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Dialysis; Dopamine; Electrochemistry; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Statistics as Topic; Substance Withdrawal Syndrome; Ventral Tegmental Area | 2012 |
Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Immunohistochemistry; Mecamylamine; Mice; Mice, Knockout; Neocortex; Neural Stem Cells; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation | 2012 |
Morphine-induced anxiolytic-like effect in morphine-sensitized mice: involvement of ventral hippocampal nicotinic acetylcholine receptors.
Topics: Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Central Nervous System Sensitization; Hippocampus; Male; Maze Learning; Mecamylamine; Mice; Microinjections; Morphine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2013 |
Involvement of cholinergic receptors in the different stages of memory measured in the modified elevated plus maze test in mice.
Topics: Animals; Benzazepines; Male; Maze Learning; Mecamylamine; Memory; Mice; Motor Activity; Nicotine; Quinoxalines; Receptors, Cholinergic; Scopolamine; Varenicline | 2012 |
Nicotine vapor inhalation escalates nicotine self-administration.
Topics: Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mecamylamine; Molecular Sequence Data; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Volatilization | 2014 |
Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 5; Indoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrroles; Substance Withdrawal Syndrome | 2013 |
Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats.
Topics: Animals; Bungarotoxins; Chagas Cardiomyopathy; Dihydro-beta-Erythroidine; Disease Models, Animal; Electrocardiography; Heart; In Vitro Techniques; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Vagus Nerve | 2013 |
Nicotine promotes survival of cells expressing amyloid precursor protein and presenilin: implication for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Cell Survival; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Presenilins | 2013 |
Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.
Topics: Age Factors; Animals; Behavior, Animal; Benzazepines; Butanones; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chemotaxis; Chlorides; Fasting; Mecamylamine; Muscles; Mutation; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Subunits; Quinoxalines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Nicotinic; Reward; Sodium; Taste; Time Factors; Varenicline | 2013 |
Reduction in sympathetic nerve activity as a possible mechanism for the hypothermic effect of oseltamivir, an anti-influenza virus drug, in normal mice.
Topics: Animals; Antiviral Agents; Body Temperature; Hexamethonium; Hypothermia; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mecamylamine; Mice; Neuraminidase; Nicotine; Oseltamivir; Zanamivir | 2013 |
Multiple nicotine training doses in mice as a basis for differentiating the effects of smoking cessation aids.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Morphine; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Smoking Cessation; Tobacco Use Cessation Devices; Varenicline | 2013 |
Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Age Factors; Animals; Animals, Newborn; CA1 Region, Hippocampal; Cholinesterase Inhibitors; Donepezil; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Indans; Interneurons; Lethal Dose 50; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Piperidines; Rats; Soman | 2013 |
The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice.
Topics: Animals; Anisoles; Behavior, Animal; Cocaine; Conditioning, Psychological; Cyclohexanols; Dose-Response Relationship, Drug; Female; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Receptor, Cannabinoid, CB2; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2013 |
The role of the cholinergic system in the signal attenuation rat model of obsessive-compulsive disorder.
Topics: Acetylcholine; Animals; Behavior, Animal; Compulsive Behavior; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Nicotine; Obsessive-Compulsive Disorder; Oxotremorine; Physostigmine; Rats; Rats, Sprague-Dawley; Scopolamine | 2013 |
Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia.
Topics: Animals; Ataxia; Benzazepines; Cerebellum; Dose-Response Relationship, Drug; Gait; Male; Mecamylamine; Motor Activity; Nerve Degeneration; Neural Pathways; Niacinamide; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Olivary Nucleus; Postural Balance; Pyridines; Quinoxalines; Rats; Rotarod Performance Test; Varenicline | 2013 |
Role of the medial septum cholinoceptors in anxiogenic-like effects of nicotine.
Topics: Animals; Anxiety; Atropine; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; Male; Maze Learning; Mecamylamine; Microinjections; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Rats; Receptors, Cholinergic; Septum of Brain | 2013 |
Ghrelin and nicotine stimulate equally the dopamine release in the rat amygdala.
Topics: Amygdala; Animals; Dopamine; Ghrelin; In Vitro Techniques; Male; Mecamylamine; Nicotine; Oligopeptides; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Ghrelin; Receptors, Nicotinic | 2013 |
[Influence of agonist and antagonist Nalpha7-cholinoreceptors on active avoidance learning and gonadal hormones levels in ovariectomized female rats].
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Cholinergic Agonists; Cholinergic Antagonists; Estradiol; Estrogens; Female; Gonadal Hormones; Mecamylamine; Nicotine; Ovariectomy; Rats; Receptors, Cholinergic; Receptors, Nicotinic | 2013 |
[Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats].
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Estradiol; Estrogens; Exploratory Behavior; Female; Grooming; Mecamylamine; Nicotine; Nicotinic Antagonists; Ovariectomy; Rats; Rats, Wistar; Receptors, Cholinergic | 2013 |
The effects of nicotine and tobacco particulate matter on dopamine uptake in the rat brain.
Topics: Aconitine; Animals; Brain; Dihydro-beta-Erythroidine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Mecamylamine; Nicotiana; Nicotine; Nicotinic Antagonists; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smoking; Tobacco Smoke Pollution | 2014 |
Volatile anesthetic isoflurane inhibits LTP induction of hippocampal CA1 neurons through α4β2 nAChR subtype-mediated mechanisms.
Topics: Anesthetics, Inhalation; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; CA1 Region, Hippocampal; Dihydro-beta-Erythroidine; Drug Interactions; Electric Stimulation; In Vitro Techniques; Isoflurane; Long-Term Potentiation; Mecamylamine; Muscarinic Agonists; Neural Pathways; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2013 |
Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells.
Topics: Aconitine; Animals; Cell Line; Cell Line, Tumor; Gene Expression Regulation; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; PC12 Cells; Racemases and Epimerases; Rats; Receptors, Nicotinic; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Pharmacological modulation of farnesyltransferase subtype I attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Male; Mecamylamine; Methionine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Substance Withdrawal Syndrome | 2013 |
Interoceptive conditioning in rats: effects of using a single training dose or a set of 5 different doses of nicotine.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley | 2013 |
Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms.
Topics: Animals; GABAergic Neurons; Glutamic Acid; Light; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phototherapy; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Rhodopsin; Somatostatin; Substance Withdrawal Syndrome; Synaptic Transmission | 2013 |
Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish.
Topics: Aconitine; Alkaloids; Animals; Azocines; Cholinergic Agents; Conotoxins; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Maze Learning; Mecamylamine; Memory; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic; Scopolamine; Swimming; Zebrafish; Zebrafish Proteins | 2014 |
Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2014 |
A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Genetic Predisposition to Disease; Humans; Mecamylamine; Membrane Potentials; Mutation, Missense; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Polymorphism, Single Nucleotide; Receptors, Nicotinic; Species Specificity; Tobacco Use Disorder; Xenopus laevis | 2014 |
Modulation of HCN channels in lateral septum by nicotine.
Topics: Action Potentials; Animals; Biophysical Phenomena; Biophysics; Cyclic Nucleotide-Gated Cation Channels; Dihydro-beta-Erythroidine; Electric Stimulation; In Vitro Techniques; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Septal Nuclei | 2014 |
Enhanced alcohol-seeking behavior by nicotine in the posterior ventral tegmental area of female alcohol-preferring (P) rats: modulation by serotonin-3 and nicotinic cholinergic receptors.
Topics: Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Drug-Seeking Behavior; Ethanol; Female; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Self Administration; Serotonin; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Ventral Tegmental Area | 2014 |
A new model to study visual attention in zebrafish.
Topics: Animals; Attention; Cholinergic Antagonists; Discrimination, Psychological; Female; Male; Mecamylamine; Memory; Motion; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Photic Stimulation; Scopolamine; Visual Perception; Zebrafish | 2014 |
A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.
Topics: Acetylcholine; Aconitine; Action Potentials; Animals; Aplysia; Conotoxins; Dihydro-beta-Erythroidine; Hexamethonium; Mecamylamine; Neuroendocrine Cells; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Strychnine; Transcriptome | 2014 |
Role of α4- and α6-containing nicotinic receptors in the acquisition and maintenance of nicotine self-administration.
Topics: Analysis of Variance; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice, Transgenic; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Picolines; Pyridinium Compounds; Receptors, Nicotinic; Self Administration; Sucrose; Sweetening Agents | 2015 |
Discriminative stimulus and hypothermic effects of some derivatives of the nAChR agonist epibatidine in mice.
Topics: Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Dihydro-beta-Erythroidine; Discrimination Learning; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic | 2014 |
Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
Topics: Animals; Anxiety; Aryl Hydrocarbon Hydroxylases; Conditioning, Psychological; Cytochrome P450 Family 2; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Male; Mecamylamine; Methoxsalen; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Reward; Severity of Illness Index; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2014 |
A comparison of mecamylamine and bupropion effects on memory-related responses induced by nicotine and scopolamine in the novel object recognition test in mice.
Topics: Analysis of Variance; Animals; Bupropion; Cholinergic Agents; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Mecamylamine; Memory; Mice; Nicotine; Pattern Recognition, Visual; Scopolamine | 2014 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumazenil; GABA Modulators; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Substance Withdrawal Syndrome; Substance-Related Disorders | 2014 |
The discriminative stimulus effects of mecamylamine in nicotine-treated and untreated rhesus monkeys.
Topics: Animals; Discrimination Learning; Female; Macaca mulatta; Male; Mecamylamine; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Substance Withdrawal Syndrome | 2014 |
Baclofen prevented the changes in c-Fos and brain-derived neutrophic factor expressions during mecamylamine-precipitated nicotine withdrawal in mice.
Topics: Animals; Baclofen; Basal Ganglia; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organ Specificity; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome | 2014 |
Endogenous ACh suppresses LTD induction and nicotine relieves the suppression via different nicotinic ACh receptor subtypes in the mouse hippocampus.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Hippocampus; Long-Term Potentiation; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic | 2014 |
Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia.
Topics: Amnesia; Animals; Central Amygdaloid Nucleus; Dose-Response Relationship, Drug; Male; Mecamylamine; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Piperazines; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Nicotinic; Serotonin 5-HT1 Receptor Antagonists; Serotonin Agents | 2014 |
Null mutation of the β2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice.
Topics: Anhedonia; Animals; Gene Deletion; Male; Mecamylamine; Mice; Mice, Knockout; Microinjections; Nicotine; Receptors, Nicotinic; Reward; Self Stimulation; Substance Withdrawal Syndrome | 2015 |
A two-injection protocol for nicotine sensitization.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Time Factors | 2014 |
Ventral hippocampal nicotinic acetylcholine receptors mediate stress-induced analgesia in mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Male; Mecamylamine; Mice; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociception; Pain Measurement; Pain Threshold; Reaction Time; Receptors, Nicotinic; Stress, Psychological; Time Factors | 2015 |
[Effect of alpha4beta2 nicotinic acetylcholine receptor agonists and antagonists on learning in female rats during different phases of ovary cycle].
Topics: Animals; Avoidance Learning; Estrous Cycle; Female; Learning; Maze Learning; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Subunits; Rats; Receptors, Nicotinic | 2014 |
Nicotine increases impulsivity and decreases willingness to exert cognitive effort despite improving attention in "slacker" rats: insights into cholinergic regulation of cost/benefit decision making.
Topics: Animals; Attention; Cholinergic Antagonists; Cognition; Decision Making; Impulsive Behavior; Male; Mecamylamine; Nicotine; Oxotremorine; Rats; Rats, Long-Evans; Reward; Scopolamine | 2014 |
Age-related changes in functional postsynaptic nicotinic acetylcholine receptor subunits in neurons of the laterodorsal tegmental nucleus, a nucleus important in drug addiction.
Topics: Acetylcholine; Aging; Animals; In Vitro Techniques; Mecamylamine; Membrane Potentials; Mice; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Receptors, Nicotinic; Synaptic Potentials; Tegmentum Mesencephali | 2016 |
Reinforcer devaluation as a consequence of acute nicotine exposure and withdrawal.
Topics: Anhedonia; Animals; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; Substance Withdrawal Syndrome; Sucrose | 2015 |
[Influence of stimulation and blockade of α4β2 nicotinic acetylcholine receptors on learning of female rats in basic phases of ovary cycle].
Topics: Animals; Animals, Outbred Strains; Avoidance Learning; Drug Administration Schedule; Estrous Cycle; Female; Injections, Intraperitoneal; Maze Learning; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ovary; Rats; Receptors, Nicotinic; Space Perception; Water | 2014 |
Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.
Topics: Animals; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; Male; Mecamylamine; Mice, Inbred BALB C; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, GABA-A; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2015 |
Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways.
Topics: Amphetamine; Animals; Behavior, Animal; Choice Behavior; Decision Making; Gambling; Male; Mecamylamine; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Oxotremorine; Rats; Rats, Long-Evans; Reward; Scopolamine | 2015 |
Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in rats.
Topics: Animals; Brain; Brain Mapping; Cerebrovascular Circulation; Compulsive Behavior; Dose-Response Relationship, Drug; Magnetic Resonance Imaging; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxygen; Rats, Wistar; Reward | 2014 |
Revisiting the effect of nicotine on interval timing.
Topics: Animals; Appetitive Behavior; Male; Mecamylamine; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Reward; Time Perception | 2015 |
Nicotinic Mechanisms Modulate Ethanol Withdrawal and Modify Time Course and Symptoms Severity of Simultaneous Withdrawal from Alcohol and Nicotine.
Topics: Animals; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Female; Habenula; Interpeduncular Nucleus; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Microinjections; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Substance Withdrawal Syndrome; Time Factors | 2015 |
Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats.
Topics: Acoustic Stimulation; Amphetamine; Animals; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Female; Habenula; Haloperidol; Mecamylamine; Nicotine; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reflex, Startle; Sensory Gating | 2015 |
Effects of continuous nicotine treatment and subsequent termination on cocaine versus food choice in male rhesus monkeys.
Topics: Animals; Choice Behavior; Cocaine; Dose-Response Relationship, Drug; Food; Macaca mulatta; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Self Administration | 2015 |
Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats.
Topics: Animals; Brain; Indoles; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Pyrrolidines; Rats, Wistar; Receptors, Vasopressin; Reward; Self Stimulation; Substance Withdrawal Syndrome | 2015 |
Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice.
Topics: Animals; Body Weight; Brain; Cotinine; Disease Models, Animal; Eating; Electronic Nicotine Delivery Systems; Emotions; Male; Mecamylamine; Memory, Short-Term; Mice, Inbred BALB C; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Respiration, Artificial; Spatial Memory; Substance Withdrawal Syndrome; Tobacco Smoke Pollution; Tobacco Use Disorder | 2015 |
Comparison of effects produced by nicotine and the α4β2-selective agonist 5-I-A-85380 on intracranial self-stimulation in rats.
Topics: Animals; Azetidines; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mecamylamine; Medial Forebrain Bundle; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Self Stimulation | 2016 |
A Two-Day Continuous Nicotine Infusion Is Sufficient to Demonstrate Nicotine Withdrawal in Rats as Measured Using Intracranial Self-Stimulation.
Topics: Animals; Infusions, Intravenous; Male; Mecamylamine; Nicotine; Rats, Wistar; Self Stimulation; Substance Withdrawal Syndrome | 2015 |
N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice.
Topics: Acetylcysteine; Animals; Association Learning; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2016 |
Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azetidines; Body Temperature; Central Nervous System Depressants; Drug Interactions; Ethanol; Hypnotics and Sedatives; Hypothermia; Ketamine; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pentobarbital; Pyridines; Receptors, Nicotinic; Reflex, Righting; Varenicline | 2016 |
Cognitive control deficits during mecamylamine-precipitated withdrawal in mice: Possible links to frontostriatal BDNF imbalance.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition; Corpus Striatum; Executive Function; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Substance Withdrawal Syndrome | 2016 |
Nicotine Directly Induces Endoplasmic Reticulum Stress Response in Rat Placental Trophoblast Giant Cells.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Cell Line; Dose-Response Relationship, Drug; eIF-2 Kinase; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation; Giant Cells; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphorylation; Rats; Receptors, Nicotinic; RNA, Messenger; Signal Transduction; Taurochenodeoxycholic Acid; Time Factors; Trophoblasts | 2016 |
Strain dependency of the effects of nicotine and mecamylamine in a rat model of attention.
Topics: Animals; Attention; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Nicotinic; Species Specificity | 2016 |
Activation of the dorsal hippocampal nicotinic acetylcholine receptors improves tamoxifen-induced memory retrieval impairment in adult female rats.
Topics: Aging; Animals; Avoidance Learning; Female; Hippocampus; Mecamylamine; Memory; Memory Disorders; Nicotine; Nicotinic Agonists; Rats, Wistar; Receptors, Nicotinic; Tamoxifen | 2016 |
Developing a model of limited-access nicotine consumption in C57Bl/6J mice.
Topics: Animals; Baclofen; Ethanol; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Models, Animal; Nicotine; Saccharin; Self Administration | 2016 |
Nicotine-induced behavioral sensitization in an adult rat model of attention deficit/hyperactivity disorder (ADHD).
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, Animal; Locomotion; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2016 |
Microinjection of acetylcholine into cerebellar fastigial nucleus induces blood depressor response in anesthetized rats.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Atropine; Blood Pressure; Cerebellar Nuclei; Dose-Response Relationship, Drug; Male; Mecamylamine; Microinjections; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Urethane | 2016 |
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
Topics: Animals; Anxiety; Corticotropin-Releasing Hormone; Dependovirus; Disease Models, Animal; Genetic Vectors; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Nicotinic; Reward; Self Stimulation; Septal Nuclei; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2016 |
Abuse liability assessment of an e-cigarette refill liquid using intracranial self-stimulation and self-administration models in rats.
Topics: Animals; Dose-Response Relationship, Drug; Electronic Nicotine Delivery Systems; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Self Stimulation | 2016 |
Striatal cholinergic interneurons and D2 receptor-expressing GABAergic medium spiny neurons regulate tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Channelrhodopsins; Choline O-Acetyltransferase; Cholinergic Neurons; Corpus Striatum; Disease Models, Animal; GABAergic Neurons; Gene Expression Regulation; Haloperidol; Male; Mastication; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Dopamine D2; Tardive Dyskinesia | 2016 |
Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Cell Line; Dihydro-beta-Erythroidine; Enterochromaffin Cells; Enteroendocrine Cells; Gene Expression Regulation; Intestinal Mucosa; Mecamylamine; Mice; Nicotine; Receptors, G-Protein-Coupled; Receptors, Nicotinic; RNA, Messenger | 2016 |
Pharmacokinetics and pharmacodynamics of oral mecamylamine - development of a nicotinic acetylcholine receptor antagonist cognitive challenge test using modelling and simulation.
Topics: Adult; Blood Pressure; Cognition; Humans; Male; Mecamylamine; Memory, Short-Term; Nicotine; Nicotinic Antagonists; Reaction Time; Receptors, Nicotinic; Young Adult | 2017 |
Chronic nicotine treatment decreases LPS signaling through NF-κB and TLR-4 modulation in the hippocampus.
Topics: Aconitine; Animals; Hippocampus; Inflammation; Lipopolysaccharides; Male; Mecamylamine; NF-kappa B; Nicotine; Nicotinic Agonists; Rats, Wistar; Receptors, Nicotinic; Signal Transduction; Toll-Like Receptor 4 | 2017 |
Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.
Topics: Alcohol Drinking; Animals; Conditioning, Classical; Cues; Drug-Seeking Behavior; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, Nicotinic | 2017 |
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline | 2017 |
Delivery of nicotine aerosol to mice via a modified electronic cigarette device.
Topics: Aerosols; Animals; Brain; Cotinine; Dose-Response Relationship, Drug; Drug Delivery Systems; Electronic Nicotine Delivery Systems; Female; Injections, Subcutaneous; Male; Mecamylamine; Mice; Mice, Inbred ICR; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Sex Characteristics | 2017 |
Both nicotine reward and withdrawal are enhanced in a rodent model of diabetes.
Topics: Animals; Conditioning, Psychological; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Rodentia; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2017 |
Brain nicotinic acetylcholine receptors are involved in stress-induced potentiation of nicotine reward in rats.
Topics: Animals; Basolateral Nuclear Complex; Behavior, Animal; CA1 Region, Hippocampal; Conditioning, Classical; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Stress, Psychological | 2017 |
The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cholinergic Agonists; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oligopeptides; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Stress, Psychological; Substance Withdrawal Syndrome; Tobacco Use Disorder; Yohimbine | 2017 |
Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal.
Topics: Amino Acids; Animals; Disease Models, Animal; Dopamine; Female; Glutamic Acid; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Sex Factors; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2018 |
Reduction in delay discounting due to nicotine and its attenuation by cholinergic antagonists in Lewis and Fischer 344 rats.
Topics: Animals; Delay Discounting; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Rats; Rats, Inbred F344; Rats, Inbred Lew; Scopolamine | 2018 |
Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats.
Topics: Administration, Inhalation; Animals; Arrhythmias, Cardiac; Cigarette Smoking; Female; Mecamylamine; Nicotine; Nicotinic Antagonists; Ovary; Pregnancy; Rats, Sprague-Dawley; Receptors, Nicotinic; Regional Blood Flow; Uterus | 2017 |
Reflex bronchoconstriction evoked by inhaled nicotine aerosol in guinea pigs: role of the nicotinic acetylcholine receptor.
Topics: Administration, Inhalation; Aerosols; Animals; Atropine; Bronchi; Bronchoconstriction; Electronic Nicotine Delivery Systems; Guinea Pigs; Lung; Male; Mecamylamine; Nebulizers and Vaporizers; Nerve Fibers, Unmyelinated; Nicotine; Receptors, Nicotinic; Reflex; Smoke; Smoking; TRPA1 Cation Channel; Vagus Nerve | 2018 |
Nicotine drug discrimination and nicotinic acetylcholine receptors in differentially reared rats.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Environment; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Social Isolation; Ventral Tegmental Area | 2018 |
Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Infusion Pumps; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Substance Withdrawal Syndrome | 2018 |
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.
Topics: Animals; Brain Injuries, Traumatic; Cerebral Cortex; Conditioning, Classical; Glycine; Male; Mecamylamine; Mice; Nicotine; Oleic Acids; Oxazoles; PPAR alpha; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2019 |
Nicotine induces aberrant hypermethylation of tumor suppressor genes in pancreatic epithelial ductal cells.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Apoptosis; Azacitidine; Cell Line; Cell Proliferation; DNA Methylation; Down-Regulation; Epithelial Cells; Genes, Tumor Suppressor; Humans; MAP Kinase Signaling System; Mecamylamine; Methyltransferases; Nicotine; Pancreatic Ducts; RNA, Messenger; Up-Regulation | 2018 |
Genetic correlations between nicotine reinforcement-related behaviors and propensity toward high or low alcohol preference in two replicate mouse lines.
Topics: Alcoholism; Animals; Biogenic Monoamines; Female; Genotype; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Reinforcement, Psychology; Tobacco Smoking | 2019 |
Nicotine is neuroprotective to neonatal neurons of sympathetic ganglion in rat.
Topics: Animals; Animals, Newborn; Apoptosis; Bungarotoxins; Cell Survival; Cells, Cultured; Mecamylamine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Growth Factor; Neurons; Neuroprotection; Neuroprotective Agents; Nicotine; Rats; Superior Cervical Ganglion | 2019 |
Nicotine and sleep deprivation: impact on pain sensitivity and immune modulation in rats.
Topics: Animals; Hyperalgesia; Immunity; Interleukin-4; Interleukin-6; Male; Mecamylamine; Nicotine; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Sleep Deprivation; Sleep, REM; Tumor Necrosis Factor-alpha | 2018 |
Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Macaca mulatta; Male; Mecamylamine; Nicotine; Nicotinic Agonists | 2019 |
Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats.
Topics: Administration, Inhalation; Animals; Body Temperature; Central Nervous System Stimulants; Dronabinol; Electronic Nicotine Delivery Systems; Locomotion; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Tobacco Use Disorder | 2019 |
Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine.
Topics: Anhedonia; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrodes, Implanted; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Self Administration; Self Stimulation; Time Factors; Tobacco Use Disorder | 2020 |
Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Behavior, Animal; Female; Gene Expression; Interpeduncular Nucleus; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Receptors, Nicotinic; RNA, Messenger; Sex Factors; Substance Withdrawal Syndrome | 2019 |
Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats.
Topics: Animals; Anxiety; Brain; Estrous Cycle; Female; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Stimulation; Sex Characteristics; Substance Withdrawal Syndrome | 2019 |
Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus.
Topics: Animals; Gene Expression Regulation; Hippocampus; Male; Mecamylamine; Mice; Mice, Transgenic; Molecular Chaperones; Neuronal Plasticity; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Synaptic Transmission | 2019 |
Differential expression of nicotine withdrawal as a function of developmental age in the rat.
Topics: Age Factors; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Infusions, Subcutaneous; Locomotion; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2019 |
Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.
Topics: Analgesia; Animals; Capsaicin; Cholinergic Neurons; Hyperalgesia; Male; Mecamylamine; Nicotine; Nociception; Nucleus Accumbens; Pain; Pain Management; Pain Measurement; Rats; Rats, Wistar; Stress, Psychological | 2020 |
Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro-β-erythroidine in nicotine-tolerant mice.
Topics: Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Smoking Cessation | 2020 |
Repeated nicotine vapor inhalation induces behavioral sensitization in male and female C57BL/6 mice.
Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Female; Inhalation Exposure; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Motor Activity; Nicotine | 2020 |
The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal.
Topics: Animals; Anxiety; Conditioning, Psychological; Depression; Female; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Pituitary Adenylate Cyclase-Activating Polypeptide; Sex Factors; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2020 |
The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Grooming; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Antagonists; Social Interaction | 2020 |
Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors.
Topics: Acetylcholine; Animals; Dihydro-beta-Erythroidine; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2020 |
Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Benzazepines; Conditioning, Operant; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Prazosin; Propranolol; Rats; Receptors, Nicotinic; Reinforcement, Psychology | 2021 |
Nicotinic receptor modulation of the default mode network.
Topics: Adult; Brain; Cognition; Cognitive Dysfunction; Default Mode Network; Female; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Mecamylamine; Middle Aged; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Reaction Time; Receptors, Nicotinic; Task Performance and Analysis | 2021 |
Nicotine chronic tolerance development and withdrawal in the planaria (Schmidtea mediterranea).
Topics: Animals; Behavior, Addictive; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Locomotion; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Planarians; Receptors, Nicotinic; Substance Withdrawal Syndrome | 2021 |
Self-Administration of Cotinine in Wistar Rats: Comparisons to Nicotine.
Topics: Animals; Cotinine; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Receptors, Nicotinic; Self Administration; Varenicline | 2021 |
Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diet, High-Fat; Female; Humans; Imidazoles; Inflammasomes; Inflammation; Mammary Neoplasms, Animal; Mecamylamine; Mice; Neoplasm Transplantation; Neoplastic Stem Cells; Nicotine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Up-Regulation | 2020 |
Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques.
Topics: Animals; Macaca mulatta; Mecamylamine; Nicotine; Receptors, Muscarinic; Spatial Memory | 2021 |
Magnitude of open-field thigmotaxis during mecamylamine-precipitated nicotine withdrawal in rats is influenced by mecamylamine dose, duration of nicotine infusion, number of withdrawal episodes, and age.
Topics: Age Factors; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Locomotion; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Taxis Response; Time Factors | 2021 |
Nicotine-free vapor inhalation produces behavioral disruptions and anxiety-like behaviors in mice: Effects of puff duration, session length, sex, and flavor.
Topics: Administration, Inhalation; Adolescent; Animals; Anxiety; Behavior, Animal; E-Cigarette Vapor; Electronic Nicotine Delivery Systems; Female; Flavoring Agents; Humans; Locomotion; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Sex Factors; Time Factors; Vaping | 2021 |
Serotonin neurons in the median raphe nucleus bidirectionally regulate somatic signs of nicotine withdrawal in mice.
Topics: Animals; Female; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Optogenetics; Raphe Nuclei; Receptors, Nicotinic; Serotonergic Neurons; Serotonin; Substance Withdrawal Syndrome | 2021 |
Nicotine Enhances Object Recognition Memory via Stimulating α4β2 and α7 Nicotinic Acetylcholine Receptors in the Medial Prefrontal Cortex of Mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dihydro-beta-Erythroidine; Male; Mecamylamine; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Receptors, Nicotinic; Recognition, Psychology | 2021 |
Further pharmacological characterization of a preclinical model of the early development of nicotine withdrawal.
Topics: Animals; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Self Stimulation; Substance Withdrawal Syndrome | 2021 |
Dynamic activity of interpeduncular nucleus GABAergic neurons controls expression of nicotine withdrawal in male mice.
Topics: Animals; GABAergic Neurons; Interpeduncular Nucleus; Male; Mecamylamine; Mice; Nicotine; Substance Withdrawal Syndrome | 2022 |
Nicotinic aspects of the discriminative stimulus effects of arecoline.
Topics: Animals; Arecoline; Behavior, Animal; Dihydro-beta-Erythroidine; Discrimination Learning; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Receptors, Nicotinic; Substance-Related Disorders | 2021 |
Chronic infusions of mecamylamine into the medial habenula: Effects on nicotine self-administration in rats.
Topics: Animals; Female; Habenula; Infusions, Intraventricular; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; Self Administration | 2022 |
The emergence of insulin resistance following a chronic high-fat diet regimen coincides with an increase in the reinforcing effects of nicotine in a sex-dependent manner.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Dose-Response Relationship, Drug; Female; Insulin Resistance; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Reinforcement, Psychology; Sex Factors; Streptozocin | 2021 |
Exploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice.
Topics: Animals; Mecamylamine; Mice; Nicotine; rho GTP-Binding Proteins; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2022 |
Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain.
Topics: Animals; Dopamine; Glutamic Acid; Hypoxia; Mecamylamine; Nicotine; Nicotinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Nicotinic; Tobacco Use Disorder; Ventral Tegmental Area | 2022 |
Nicotine promotes the utility of short-term memory during visual search in macaque monkeys.
Topics: Animals; Haplorhini; Macaca; Mecamylamine; Memory, Short-Term; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Receptors, Muscarinic | 2022 |
Nicotinic stimulation of splenic T cells is protective in endoscopic retrograde cholangiopancreatography-induced acute pancreatitis in mice.
Topics: Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholangiopancreatography, Endoscopic Retrograde; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Pancreatitis; Spleen; T-Lymphocytes | 2022 |
Nicotinic and muscarinic acetylcholine receptor antagonism dose-dependently decreases sign- but not goal-tracking behavior in male rats.
Topics: Animals; Cues; Male; Mecamylamine; Motivation; Nicotine; Rats; Rats, Sprague-Dawley; Reward; Scopolamine Derivatives | 2023 |
Assessment of Abuse-Related Discriminative Stimulus Effects of Nicotine Aerosol in Rodents.
Topics: Aerosols; Animals; Electronic Nicotine Delivery Systems; Humans; Mecamylamine; Nicotine; Rats; Rodentia | 2023 |
L-theanine attenuates nicotine reward and withdrawal signs in mice.
Topics: Animals; Humans; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome | 2023 |