nicotine has been researched along with imipramine in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (43.59) | 18.7374 |
| 1990's | 7 (8.97) | 18.2507 |
| 2000's | 23 (29.49) | 29.6817 |
| 2010's | 13 (16.67) | 24.3611 |
| 2020's | 1 (1.28) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, DE; L'Italien, YJ; Marriott, JG; Nordin, IC; Poschel, PH; Zweisler, L | 1 |
| Butler, DE; Marriott, JG; Poschel, BP | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y | 1 |
| Keserü, GM | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Abraham, R; Bhyrapuneni, G; Bogaraju, N; Jasti, V; Mekala, VR; Mohammed, AR; Muddana, N; Nirogi, R; Palacharla, RC; Ravella, SR; Shinde, AK; Subramanian, R; Thentu, JB | 1 |
| Lisciani, R; Silvestrini, B | 1 |
| Berger, G; Comar, D; Knipper, R; Maziere, M; Prenant, C | 1 |
| Chiba, S; Furukawa, Y; Karasawa, Y; Murakami, M; Narita, M; Ren, LM; Takei, M | 1 |
| Andersen, PH; Bjerring, P; Maibach, HI; Nangia, A | 1 |
| Fellhauer, M | 1 |
| Heldman, E; Levine, M; Pollard, HB; Raveh, L | 1 |
| Creech, BJ; Smith, KR | 1 |
| Bevan, JA | 1 |
| Dhalla, NS | 1 |
| Oliverio, A | 1 |
| Dhawan, BN; Singh, HK; Srimal, RC | 1 |
| Oldendorf, WH | 2 |
| Doi, T; Kojima, S; Tsujimoto, A | 1 |
| Hagström, BE; Lönning, S | 1 |
| Carella, A; Fiorese, FF; Orfei, B; Pirl, JN | 1 |
| Cheng, HC; Long, JP | 1 |
| Izquierdo, I; Izquierdo, JA | 1 |
| Harmon, JB; Lynes, TE; Marvel, JP; Smith, DH; Stump, JM; Vernier, VG | 1 |
| Baden, MM; Valanju, NN; Valanju, SN; Verma, SK | 1 |
| Tauberger, G | 1 |
| Tammisto, T; Ylitalo, P | 1 |
| Gorosito, M; Sabelli, HC | 1 |
| Morrison, CF; Stephenson, JA | 1 |
| Bhargava, LP; Dandiya, PC | 1 |
| Zetler, G | 1 |
| Bertazzoli, C; Bonsignori, A; Chieli, T; Pegrassi, L; Suchowsky, GK | 1 |
| Haas, H; Jantos, W | 1 |
| Hoffmeister, F; Kroneberg, G; Wuttke, W | 1 |
| Hoffmeister, F | 1 |
| Ceña, V; Garcia, AG; Kirpekar, SM; Nicolas, GP; Sanchez-Garcia, P | 1 |
| Ceña, V; García, AG; Montiel, C; Sánchez-García, P | 1 |
| Andersson, A; Olsson, S; Tjälve, H | 1 |
| Kuribara, H | 1 |
| Ceña, V; Fernández-Fernández, JM; González-García, C; Izaguirre, V | 1 |
| Boyle, M; Cunningham, C; Jadad, AR; Kim, M; Schachar, R | 1 |
| Brodkin, JD; Ferguson, SM; Lloyd, GK; Menzaghi, F | 1 |
| Kozela, E; Krawczyk, M; Popik, P | 1 |
| ALHA, AR; LEVONEN, E; MUKULA, AL; RUOHONEN, A; SALOMAA, E; TAMMINEN, V | 1 |
| ROBSON, JM | 1 |
| Baghdadi, B; Sahebgharani, M; Zarrindast, MR | 1 |
| Antkiewicz-Michaluk, L; Kos, T; Kowalska, M; Krawczyk, M; Nalepa, I; Popik, P; Vetulani, J; Witarski, T | 1 |
| Bobrovskaya, L; Bolster, EK; Dickson, PW; Dunkley, PR; Flaherty, JJ; Gilligan, C | 1 |
| Harvey, I; Lilford, R; Song, F | 1 |
| Booth-Genthe, CL; Grimm, SW; Guo, J; Linnenbach, AJ; Zhou, D | 1 |
| Filip, M; McCreary, AC; Wydra, K; Zaniewska, M | 1 |
| Grimm, SW; Guo, J; Zhou, D | 1 |
| Bevins, RA; Dion, AM; Murrin, LC; Sanderson, SC | 1 |
| Biala, G; Boguszewska-Czubara, A; Budzynska, B; Grot, K; Kruk-Slomka, M; Michalak, A; Pekala, K | 1 |
| Gorev, NP; Ionov, ID; Pushinskaya, II; Shpilevaya, LA | 1 |
5 review(s) available for nicotine and imipramine
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Effects of drugs on deep brain centers.
Topics: Acetylcholine; Acetylcholinesterase; Amphetamine; Amygdala; Binding Sites; Blood-Brain Barrier; Brain; Catecholamines; Hippocampus; Imipramine; Injections; Learning; Metabolism; Nicotine; Parasympathetic Nervous System; Potassium; Receptors, Adrenergic; Receptors, Cholinergic | 1971 |
Treatment of attention-deficit/hyperactivity disorder.
Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child Behavior; Combined Modality Therapy; Desipramine; Dextroamphetamine; Evidence-Based Medicine; Follow-Up Studies; Humans; Imipramine; Methylphenidate; Nicotine; Nicotinic Agonists; Pemoline; Phenylalanine; Placebos; Randomized Controlled Trials as Topic; Safety; Treatment Outcome | 1999 |
THE PROBLEM OF TERATOGENICITY.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Cyclizine; Female; Imipramine; Nicotine; Pregnancy; Pregnancy Complications; Research; Sodium Salicylate; Thalidomide; Toxicology | 1963 |
Adjusted indirect comparison may be less biased than direct comparison for evaluating new pharmaceutical interventions.
Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Bias; Bupropion; Data Interpretation, Statistical; Drug Therapy; Fluoxetine; Haloperidol; Humans; Imipramine; Meta-Analysis as Topic; Nicotine; Randomized Controlled Trials as Topic; Risperidone; Schizophrenia; Smoking Cessation; Treatment Outcome | 2008 |
1 trial(s) available for nicotine and imipramine
| Article | Year |
|---|---|
Chemical and pharmacologic skin irritation in man. A reflectance spectroscopic study.
Topics: Adult; Aminoquinolines; Erythema; Female; Hemoglobins; Humans; Hydrogen-Ion Concentration; Imipramine; Middle Aged; Nicotine; Patch Tests; Phenylpropanolamine; Spectrophotometry | 1991 |
72 other study(ies) available for nicotine and imipramine
| Article | Year |
|---|---|
Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam.
Topics: Amnesia; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Humans; Male; Mice; Mice, Inbred Strains; Pyrrolidines; Structure-Activity Relationship | 1984 |
Cognition-activating properties of 3-(Aryloxy)pyridines.
Topics: Animals; Cognition; Dose-Response Relationship, Drug; Male; Mice; Psychotropic Drugs; Pyridines; Structure-Activity Relationship | 1981 |
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression.
Topics: Administration, Oral; Animals; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Halogenation; Humans; Male; Nicotinic Antagonists; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic | 2020 |
Experimental data suggesting an adrenergic mechanism in the production of parkinsonian symptoms.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Clonidine; Female; Fenclonine; Imipramine; Male; Mice; Mice, Inbred Strains; Nicotine; Oxotremorine; Parkinson Disease, Secondary; Phenoxybenzamine; Piloerection; Pyrilamine; Rabbits; Salivation; Sympathetic Nervous System; Trazodone; Tremor | 1976 |
Automated synthesis of 11C-labelled radiopharmaceuticals: imipramine, chlorpromazine, nicotine and methionine.
Topics: Carbon Radioisotopes; Chlorpromazine; Imipramine; Isotope Labeling; Methionine; Nicotine | 1979 |
Effects of tetrodotoxin and imipramine on the cardiac responses to nicotine in isolated, blood-perfused canine heart preparations.
Topics: Animals; Coronary Circulation; Dogs; Electrocardiography; Electrodes; Heart; Heart Atria; Heart Rate; Heart Ventricles; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Myocardial Contraction; Nicotine; Propranolol; Tetrodotoxin | 1991 |
[Drug treatment of nicotine dependence].
Topics: Clonidine; Doxepin; Humans; Imipramine; Mecamylamine; Nicotine; Smoking; Substance Withdrawal Syndrome | 1990 |
Barium ions enter chromaffin cells via voltage-dependent calcium channels and induce secretion by a mechanism independent of calcium.
Topics: Animals; Barium; Binding, Competitive; Biological Transport; Calcium; Calcium Channels; Catecholamines; Cations, Divalent; Cattle; Cells, Cultured; Chromaffin System; Digitonin; Egtazic Acid; Imipramine; Kinetics; Nicotine; Osmolar Concentration; Potassium Chloride; Trifluoperazine | 1989 |
Effects of pharmacological agents on the physiological responses of hair discs.
Topics: Acetylcholine; Action Potentials; Alkaloids; Amitriptyline; Animals; Anticonvulsants; Calcium; Catecholamines; Desipramine; Electric Stimulation; Hair; Imipramine; Lobeline; Magnesium; Monoamine Oxidase Inhibitors; Nicotine; Parasympathomimetics; Plants, Medicinal; Plants, Toxic; Potassium; Rats; Reserpine; Sensory Receptor Cells; Serotonin; Skin Physiological Phenomena; Synaptic Transmission; Touch; Veratrum | 1967 |
Some structural considerations of the reactivity of vascular smooth muscle.
Topics: Angiotensin II; Animals; Aorta; Blood Vessels; Bretylium Compounds; Catecholamines; Cocaine; Diffusion; Electric Stimulation; Imipramine; Methods; Muscle Contraction; Muscle, Smooth; Neural Conduction; Neuroeffector Junction; Nicotine; Norepinephrine; Pulmonary Artery; Rabbits; Serotonin; Tritium; Tyramine | 1969 |
Mechanisms of sympathomimetic effects of dichloroisoproterenol: comparison with tyramine, nicotine and norepinephrine.
Topics: Animals; Atropine; Cocaine; Diaphragm; Drug Antagonism; Ganglionic Blockers; Guanidines; Heart; Heart Atria; Hexamethonium Compounds; Imipramine; In Vitro Techniques; Iproniazid; Isoproterenol; Morphine; Nicotine; Norepinephrine; Pentolinium Tartrate; Phenoxybenzamine; Propranolol; Rats; Sympatholytics; Tranylcypromine; Tyramine | 1967 |
[Anti-fatigue effect of amphetamine and central-stimulating drugs on the performance of mice during prolonged conditioning sessions].
Topics: Amitriptyline; Amphetamine; Animals; Behavior, Animal; Caffeine; Catecholamines; Central Nervous System Stimulants; Conditioning, Psychological; Imipramine; Male; Mice; Nicotine; Pentylenetetrazole; Scopolamine; Strychnine; Sympathomimetics | 1967 |
Experimental evidence for imipramine like activity of fenfluramine.
Topics: Animals; Avoidance Learning; Blepharoptosis; Blood Pressure; Body Temperature; Cats; Columbidae; Drug Antagonism; Drug Synergism; Electroshock; Female; Fenfluramine; Histamine H1 Antagonists; Hypothermia; Imipramine; Male; Mice; Nicotine; Nictitating Membrane; Rabbits; Rats; Reserpine; Respiration; Seizures; Tetrabenazine; Tremor; Tremorine; Vomiting; Yohimbine | 1970 |
Brain uptake of metabolites and drugs following carotid arterial injections.
Topics: Acetates; Amino Acids; Animals; Antipyrine; Ascorbic Acid; Aspirin; Barbiturates; Blood-Brain Barrier; Brain; Caffeine; Chloroquine; Cyanides; Ethanol; Imipramine; Lactates; Mescaline; Morphine; Neurotransmitter Agents; Nicotine; Penicillin G; Pharmaceutical Preparations; Phenytoin; Procaine; Pyruvates; Rats | 1971 |
Potent inhibitory action of pilocarpine on hepatic drug metabolism.
Topics: Aniline Compounds; Animals; Depression, Chemical; Ethylamines; Glucosephosphate Dehydrogenase; Hexobarbital; Imipramine; In Vitro Techniques; Liver; Male; Nicotine; Phenols; Pilocarpine; Proadifen; Rabbits; Spectrophotometry; Tritium | 1972 |
The sea urchin egg as a testing object in toxicology.
Topics: Animals; Bone Development; Cell Differentiation; Cell Membrane; Cell Nucleus; Chloramphenicol; Chlorpromazine; Chromosomes; Female; Fertilization; Germ Layers; Imipramine; Intestines; Larva; Male; Microscopy, Electron; Mitosis; Nicotine; Ovum; Sea Urchins; Spermatozoa; Thalidomide | 1973 |
Immediate drug detection on the spot.
Topics: Alkalies; Amines; Amphetamine; Carbamates; Cardiac Glycosides; Chemical Phenomena; Chemistry; Dicarboxylic Acids; Ethchlorvynol; Glycine; Hallucinogens; Hydrocarbons, Halogenated; Hypnotics and Sedatives; Imipramine; Indicators and Reagents; Nicotine; Peroxides; Pharmaceutical Preparations; Phenacetin; Phenothiazines; Phosphoric Acids; Quinones; Salicylates; Strychnine; Toxicology; Tranquilizing Agents | 1972 |
Dopaminergic nature of apomorphine-induced pecking in pigeons.
Topics: Animals; Apomorphine; Aporphines; Behavior, Animal; Chlorpromazine; Columbidae; Dihydroxyphenylalanine; Dioxoles; Dopamine; Haloperidol; Imipramine; Methyltyrosines; Nicotine; Oxotremorine; Phentolamine; Physostigmine; Pilocarpine; Propranolol; Receptors, Drug; Reserpine; Serotonin; Time Factors | 1974 |
The toxicologic and pharmacologic properties of amantadine hydrochloride.
Topics: Abnormalities, Drug-Induced; Acetylcholine; Amantadine; Analgesia; Animals; Arrhythmias, Cardiac; Blood Chemical Analysis; Blood Pressure; Central Nervous System; Depression; Dextroamphetamine; Dogs; Drug Synergism; Electrocardiography; Female; Guinea Pigs; Haplorhini; Heart Rate; Histamine; Horses; Humans; Imipramine; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Motor Activity; Nicotine; Norepinephrine; Phenethylamines; Rabbits; Rats; Reproduction; Tetrabenazine; Tritium | 1969 |
Confirmed identification of biotransformed drugs of abuse in urine.
Topics: Amphetamine; Analgesics; Barbiturates; Biotransformation; Caffeine; Cannabis; Chromatography, Gas; Chromatography, Thin Layer; Codeine; Humans; Hydrogen-Ion Concentration; Imipramine; Indicators and Reagents; Methadone; Morphine; Nicotine; Pharmaceutical Preparations; Procaine; Skin; Spectrum Analysis; Substance-Related Disorders; Tranquilizing Agents | 1972 |
[Inhibition of the central nervous vagus stimulating effect of nicotine by chlorpromazine, fluphenazine and imipramine].
Topics: Action Potentials; Animals; Cats; Chlorpromazine; Fluphenazine; Imipramine; Nicotine; Phrenic Nerve; Vagus Nerve | 1971 |
Tachyphylaxis and toxicity of 5HT in anaesthetized rats.
Topics: 5-Hydroxytryptophan; Anesthesia; Animals; Creatinine; Imipramine; Injections, Intravenous; Injections, Subcutaneous; Male; Neostigmine; Nialamide; Nicotine; Pentobarbital; Phenelzine; Phenylalanine; Physostigmine; Rats; Reserpine; Sensory Receptor Cells; Serotonin; Serotonin Antagonists; Tachyphylaxis; Tetrabenazine; Tryptamines | 1969 |
Evidence for biogenic amine receptors in toad sciatic nerves.
Topics: Animals; Anura; Axons; Chlorpromazine; Chlorzoxazone; Cocaine; Drug Antagonism; Epinephrine; Histamine; Imipramine; Lysergic Acid Diethylamide; Membranes; Neural Conduction; Nicotine; Nicotinic Acids; Pentolinium Tartrate; Potassium Chloride; Procaine; Sciatic Nerve; Sensory Receptor Cells; Serotonin; Sodium; Time Factors | 1969 |
Drug effects on a measure of unconditioned avoidance in the rat.
Topics: Amobarbital; Animals; Antidepressive Agents; Atropine; Avoidance Learning; Barbiturates; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Female; Imipramine; Nicotine; Pentobarbital; Rats; Tranquilizing Agents | 1970 |
The antiparkinsonian activity of monoamine oxidase inhibitors and other agents in rats and mice.
Topics: Animals; Dextroamphetamine; Diphenhydramine; Imipramine; Iproniazid; Isocarboxazid; Mice; Monoamine Oxidase Inhibitors; Nialamide; Nicotine; Nortropanes; Pargyline; Parkinson Disease; Parkinson Disease, Secondary; Perphenazine; Phenelzine; Physostigmine; Rats; Scopolamine; Sulfonic Acids; Tolazoline; Tremor; Tremorine; Trihexyphenidyl; Tryptamines | 1968 |
Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Catalepsy; Desipramine; Hexamethonium Compounds; Humans; Hypothermia; Imipramine; Male; Mice; Nicotine; Nicotinic Acids; Nitrophenols; Parasympatholytics; Parasympathomimetics; Phosphoric Acids; Pilocarpine; Pralidoxime Compounds; Scopolamine; Tremorine | 1968 |
Some pharmacological properties of 4H-3-methylcarboxamide 1,3-benzoxazine-2-one (FI 6654).
Topics: Acetylcholine; Animals; Antidepressive Agents; Arousal; Atropine; Barium; Duodenum; Electroencephalography; Guinea Pigs; Histamine; Ileum; Imipramine; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Nicotine; Oxazines; Papaverine; Physostigmine; Rabbits; Rats; Seizures; Serotonin | 1969 |
[Modification of central mechanisms of action by anticholinergics].
Topics: Aggression; Amphetamine; Animals; Apomorphine; Atropine; Biperiden; Bridged-Ring Compounds; Central Nervous System; Chlorpromazine; Depression, Chemical; Drug Synergism; Esters; Female; Hexobarbital; Humans; Imipramine; Male; Mice; Morphine; Nicotine; Parasympatholytics; Pentylenetetrazole; Perphenazine; Rats; Stimulation, Chemical; Strychnine; Tremorine | 1969 |
[On the pharmacology of the thymoleptic noxiptilin (Bay 1521)].
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Blood Pressure; Cats; Central Nervous System; Depression, Chemical; Dibenzazepines; Dibenzocycloheptenes; Dogs; Drug Synergism; Epinephrine; Female; Guinea Pigs; Ileum; Imipramine; Kidney; Male; Methamphetamine; Mice; Mydriatics; Nicotine; Nictitating Membrane; Norepinephrine; Parasympatholytics; Pilocarpine; Rabbits; Rats; Salivation; Scopolamine; Stimulation, Chemical; Tranquilizing Agents | 1969 |
[Methodical problems of psychopharmacology presented using the example of antidepressive agents].
Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents; Autonomic Nervous System; Behavior, Animal; Cats; Central Nervous System; Depression, Chemical; Dibenzazepines; Dibenzocycloheptenes; Drug Synergism; Guinea Pigs; Ileum; Imipramine; Mice; Motor Activity; Nicotine; Nictitating Membrane; Norepinephrine; Parasympatholytics; Pilocarpine; Rabbits; Rats; Reserpine; Stimulation, Chemical; Tetrabenazine; Tranquilizing Agents | 1969 |
Pharmacological dissection of receptor-associated and voltage-sensitive ionic channels involved in catecholamine release.
Topics: Acetylcholine; Adrenal Medulla; Animals; Catecholamines; Cattle; Cocaine; Electrolytes; Ethers; Imipramine; Ion Channels; Ionomycin; Membrane Potentials; Nicotine; Norepinephrine; Receptors, Cholinergic; Receptors, Nicotinic; Synaptic Transmission; Tetrodotoxin; Veratridine | 1983 |
Uptake of [3H]-nicotine and [3H]-noradrenaline by cultured chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cell Membrane; Cells, Cultured; Chromaffin System; Cocaine; Imipramine; Mecamylamine; Nicotine; Norepinephrine; Tetracaine | 1984 |
Some clinical aspects of the blood-brain barrier.
Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Capillaries; Capillary Permeability; Cell Membrane Permeability; Cerebrovascular Circulation; Homeostasis; Humans; Imipramine; Nicotine; Pharmaceutical Preparations; Solubility; Tomography, X-Ray Computed | 1982 |
The uptake of 14C-chloroquine by mouse pancreatic islets in vitro.
Topics: Absorption; Animals; Chloroquine; Chlorpromazine; Desipramine; Glucose; Hydrogen-Ion Concentration; Imipramine; Islets of Langerhans; Lidocaine; Mice; Nicotine; Nitrogen; Ouabain; Quinacrine; Temperature | 1980 |
Effects of psychotropic drugs on impairment of acquisition of shuttle avoidance produced by pretreatment with pairs of tone signal and shock in mice.
Topics: Animals; Avoidance Learning; Caffeine; Chlorpromazine; Diazepam; Electroshock; Imipramine; Male; Mice; Morphine; Nicotine; Psychotropic Drugs; Signal Detection, Psychological | 1994 |
Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents, Tricyclic; Cattle; Cells, Cultured; Chromaffin Cells; Desipramine; Imipramine; Membrane Potentials; Nicotine; Nicotinic Antagonists; Potassium; Receptors, Nicotinic | 1997 |
Antidepressant-like effects of the subtype-selective nicotinic acetylcholine receptor agonist, SIB-1508Y, in the learned helplessness rat model of depression.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Depression; Dose-Response Relationship, Drug; Imipramine; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2000 |
Nicotine and nicotinic receptor antagonists potentiate the antidepressant-like effects of imipramine and citalopram.
Topics: Animals; Antidepressive Agents; Citalopram; Drug Synergism; Hindlimb Suspension; Imipramine; Immobilization; Locomotion; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic | 2003 |
[Ultra red spectroscopy in forensic chemical analysis. II. Chemical investigation in 4 fatalities: 1. Tofranil poisoning, and combination poisonings, 2. Parathion and Endrin, 3. Nicotine and parathion and 4. Pentymal, disulfiram and ethanol].
Topics: Amobarbital; Disulfiram; Endrin; Ethanol; Imipramine; Nicotine; Parathion; Poisoning; Spectrum Analysis | 1960 |
Potentiation of imipramine-induced antinociception by nicotine in the formalin test.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Imipramine; Male; Mice; Nicotine; Pain Measurement | 2004 |
Nicotine produces antidepressant-like actions: Behavioral and neurochemical evidence.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Cerebral Cortex; Dopamine Agonists; Imipramine; Male; Motor Activity; Nicotine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Time Factors | 2005 |
Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis.
Topics: Adrenal Glands; Adrenergic Uptake Inhibitors; Angiotensin II; Animals; Carbazoles; Catecholamines; Cattle; Chromaffin Cells; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Imipramine; Indoles; Maleimides; Nicotine; Nicotinic Agonists; Phosphorylation; Protein Synthesis Inhibitors; Rats; Serine; Tyrosine 3-Monooxygenase | 2007 |
Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biocatalysis; Clomipramine; Enzyme Inhibitors; Glucuronic Acid; Glucuronides; Glucuronosyltransferase; Humans; Imipramine; Kinetics; Microsomes, Liver; Nicotine; Recombinant Proteins; Sapogenins; Trimipramine | 2010 |
Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal.
Topics: Animals; Antidepressive Agents, Tricyclic; Depression; Imipramine; Male; Motor Activity; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Substance Withdrawal Syndrome; Swimming; Time Factors; Treatment Outcome | 2010 |
Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: a marker for human UGT2B10 inhibition.
Topics: Amitriptyline; Calibration; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glucuronates; Glucuronosyltransferase; Humans; Imipramine; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Nicotine; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temperature; Trifluoperazine | 2011 |
Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Generalization, Response; Imipramine; Male; Morpholines; Nicotine; Nicotinic Agonists; Norepinephrine Plasma Membrane Transport Proteins; Random Allocation; Rats; Rats, Sprague-Dawley; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Tobacco Use Disorder | 2012 |
Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats.
Topics: Animals; Behavior, Animal; Choice Behavior; Chronic Disease; Conditioning, Classical; Imipramine; Male; Metyrapone; Motor Activity; Nicotine; Oxidative Stress; Rats, Wistar; Stress, Psychological; Tobacco Use Disorder | 2018 |
Synergistic anticataleptic effect of imipramine and nicotine in a rotenone-induced rat model.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Imipramine; Insecticides; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra | 2019 |