Page last updated: 2024-08-26

nicotine and hydroxycotinine

nicotine has been researched along with hydroxycotinine in 155 studies

Research

Studies (155)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (6.45)	18.7374
1990's	22 (14.19)	18.2507
2000's	37 (23.87)	29.6817
2010's	74 (47.74)	24.3611
2020's	12 (7.74)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Altieri, I; Ottaviani, G; Pacifici, R; Pichini, S; Rosa, M; Zuccaro, P	1
Rustemeier, K; Schepers, G; Voncken, P	1
Greenwood, M; Moore, J; Sinclair, N	1
Benowitz, NL; Jacob, P; Shulgin, AT	2
Schäfer, KH; Schepers, G; Voncken, P	1
Crooks, PA; Damani, LA; Godin, CS; Houdi, AA; Nwosu, CG	1
Dünger, M; Krenz, O; Neurath, GB; Orth, D; Pein, FG	1
Adlkofer, F; Biber, A; Heller, WD; Jarczyk, L; Neurath, GB; Scherer, G	1
Schepers, G; Walk, RA	1
Crooks, PA; Nwosu, CG	1
Dünger, M; Neurath, GB; Orth, D; Pein, FG	1
Neurath, GB; Pein, FG	1
Castagnoli, N; Dagne, E	1
Caldwell, WS; de Bethizy, JD; Doolittle, DJ; Hayes, AW; Lee, CK; Winegar, R	1
Altieri, I; Pacifici, R; Passa, AR; Pichini, S; Rosa, M; Zuccaro, P	1
Andersson, G; Axéll, T; Curvall, M	1
Andersson, G; Björnberg, G; Curvall, M	1
Knapp, DK; Montes, M; Ostrea, AR; Ostrea, EM; Romero, A	1
Altieri, I; Dondero, F; Gandini, L; Lenzi, A; Pacifici, R; Pichini, S; Rosa, M; Zuccaro, P	1
Altieri, I; Pacifici, R; Passa, AR; Pichini, S; Ricciarello, G; Rosa, M; Zuccaro, P	1
Benowitz, NL; Fong, I; Gupta, S; Jacob, P	1
Altieri, I; Bacosi, A; Caronna, A; Pacifici, R; Pichini, S; Rosa, M; Zuccaro, P	1
Grimaldi, F; Oddoze, C; Rop, PP; Viala, A	1
Altieri, I; Pacifici, R; Pellegrini, M; Pichini, S; Rosa, M; Zuccaro, P	1
Andersson, G; Curvall, M; Vala, EK	1
Benowitz, NL; Jacob, P; Zevin, S	1
Anderson, R; Croghan, IT; Dale, LC; Hurt, RD; Ji, AJ; Lawson, GM	1
Köhler, E; Schuster, R; Sollich, V; Thal, W	1
Johnsson, T; Reijula, K; Tuomi, T	1
Galuska, D; Gorrod, JW; Kawano, Y; Rincón, J; Ryder, JW; Wallberg-Henriksson, H; Zierath, JR	1
Gorrod, JW; Tsai, MC	1
Benowitz, NL; Dempsey, D; Jacob, P	1
Benowitz, NL; Jacob, P	1
Hee, SS; Yim, SH	1
Ameno, K; Ameno, S; Ijiri, I; Iwahashi, K; Kinoshita, H; Kubota, T; Kumihashi, M; Mostofa, J; Zhang, X	1
Charlson, JR; Dale, LC; Ebbert, JO; Enger, RJ; Hurt, RD; Moyer, TP; Schroeder, DR	1
Benowitz, NL; Jacob, P; Pomerleau, CS; Pomerleau, OF	1
Allen, F; Benowitz, NL; Dempsey, D; Jacob, P; Schoedel, K; Tutka, P; Tyndale, RF	1
Darwin, WD; Huestis, MA; Kim, I	1
Abanyie, F; Benowitz, NL; Foulds, J; Steinberg, ML; Williams, JM; Ziedonis, DM	1
Huestis, MA; Kim, I	1
Benowitz, N; Lerman, C; Patterson, F; Pinto, A; Shields, PG; Tyndale, R; Wileyto, EP	1
Akiyama, Y; Arashidani, K; Kawano, W; Kunugita, N	1
Dixon, M; Krautter, GR; Mariner, DC; St Charles, FK	1
Goodz, SD; Malaiyandi, V; Sellers, EM; Tyndale, RF	1
Benowitz, NL; Jacob, P; Lessov-Schlaggar, CN; Swan, GE; Tyndale, RF	1
Benowitz, NL; Hukkanen, J; Jacob, P	1
Siu, EC; Tyndale, RF	1
Mwenifumbo, JC; Sellers, EM; Tyndale, RF	1
Benowitz, NL; Dempsey, DA; Levi, M; Sheiner, LB	2
Dobosz, C; Kowalska, M; Mańka, G; Tyrpień, K; Wielkoszyński, T	1
Benowitz, NL; Hu, MC; Kandel, DB; Schaffran, C; Udry, JR	1
Berlin, I; Gasior, MJ; Moolchan, ET	1
Benowitz, NL; Krasnow, RE; Lessov-Schlaggar, CN; Mwenifumbo, JC; Swan, GE; Tyndale, RF; Zhou, Q	1
Benowitz, N; Jepson, C; Lee, AM; Lerman, C; Shields, PG; Tyndale, RF	1
Avenarius, S; Gerloff, C; Jorch, G; Köhler, E; Rabsilber, A	2
Feng, S; Kapur, S; Mendes, P; Muhammad, R; Newland, K; Roethig, HJ; Sarkar, M	1
Gray, TR; Huestis, MA; Shakleya, DM	1
Hatsukami, DK; Le, C; Li, ZZ; Mooney, ME; Murphy, SE; Pentel, PR	1
Benowitz, NL; Dempsey, DA; Jacob, P; Kroetz, DL; Tutka, P	1
Akiyama, Y; Amagai, T; Arashidani, K; Hashimoto, K; Ishizu, Y; Matsuki, H; Matsushita, H	1
Gray, TR; Huestis, MA; Magri, R; Shakleya, DM	1
Ahluwalia, JS; Al Koudsi, N; Benowitz, NL; Ho, MK; Mwenifumbo, JC; Okuyemi, KS; Tyndale, RF	1
Huestis, MA; Shakleya, DM	2
Kushnir, MM; Rockwood, AL; Urry, FM; Yue, B	1
Florek, E; Kulza, M; Loba, U; Piekoszewski, W; Wilimowska, J	1
Chung, BC; Hong, J; Jung, BH; Kim, KY; Lee, YJ	1
Connors, G; Eiden, RD; Gray, TR; Huestis, MA; Leonard, KE; Shisler, S	1
Benowitz, NL; Dains, KM; Dempsey, D; Jacob, P; Yu, L	1
Benowitz, NL; Gan, Q; Glantz, SA; Goniewicz, M; Li, X; Lu, W; Xu, J	1
Benowitz, NL; Gandhi, KK; Williams, JM	1
Barr, DB; Bearer, C; Bernert, JT; Braun, JM; Daniels, JL; Hornung, R; Lanphear, BP; Olshan, AF; Poole, C; Xia, Y	1
Baer, VL; Christensen, RD; Clark, CJ; Marin, SJ; McMillin, GA	1
Benowitz, NL; Carmella, SG; Hecht, SS; Lerman, CE; Pinto, AG; Strasser, AA; Tang, KZ; Tyndale, RF	1
Ahluwalia, JS; Benowitz, NL; Bronars, CA; Choi, WS; Cox, LS; Faseru, B; Krebill, R; Mayo, MS; Nollen, NL; Okuyemi, KS; Salzman, GA; Snow, TS; Tyndale, RF	1
Hajek, P; McRobbie, H; West, O	1
Alexander, RR; Bernert, JT; Xia, Y; Xu, M	1
Grata, E; Marclay, F; Perrenoud, L; Saugy, M	1
Heishman, SJ; Huestis, MA; Marrone, GF; Scheidweiler, KB; Shakleya, DM; Singleton, EG	1
Ansermot, N; Choong, E; Cornuz, J; Dobrinas, M; Eap, CB; Noetzli, M	1
Barroso, M; Calheiros, J; da Fonseca, BM; Gallardo, E; Magalhães, AR; Moreno, IE; Queiroz, JA; Ravara, S	1
Huestis, MA; Scheidweiler, KB; Shakleya, DM	1
Benowitz, NL; Dempsey, D; Goniewicz, ML; Jacob, P; St Helen, G; Wilson, M	1
Benowitz, NL; Binnington, MJ; Hatsukami, DK; Lanier, AP; Renner, CC; Tyndale, RF; Zhu, AZ	1
Murphy, SE; Retzlaff, C; von Weymarn, LB	1
Benowitz, NL; Gandhi, KK; Lu, SE; Steinberg, ML; Williams, JM	1
Himes, SK; Huestis, MA; Niaura, RS; Scheidweiler, KB; Stroud, LR	1
De Cremer, K; Van Loco, J; Van Overmeire, I	1
Benowitz, NL; Dempsey, DA; Hammond, SK; Havel, C; Jacob, P; Jones, IA; Meyers, MJ; Northcross, A; St Helen, G	1
Shu, I; Wang, P	1
Benowitz, NL; Jacob, P; St Helen, G	1
Andrenyak, DM; Fleckenstein, AE; Nielsen, SM; Vieira-Brock, PL; Wilkins, DG	1
Ahluwalia, JS; Benowitz, NL; Cox, LS; Tyndale, RF; Zhou, Q; Zhu, AZ	1
Ande, A; Earla, R; Kumar, A; Kumar, S; McArthur, C	1
Benowitz, NL; Delucchi, KL; Hall, SM; Hendricks, PS	1
Ansari, S; Buettner, A; Esposito, M; Gebel, S; Hoeng, J; Kogel, U; Leroy, P; Martin, F; Peitsch, MC; Schlage, WK; Vanscheeuwijck, P; Wyss, C; Xiang, Y	1
Benowitz, NL; Dunbar, MS; Shiffman, S	1
Craig, EL; Cui, JZ; Miksys, S; Novalen, M; Tyndale, RF; Zhao, B	1
Chenoweth, MJ; Cinciripini, PM; George, TP; Hawk, LW; Lerman, C; Novalen, M; Schnoll, RA; Tyndale, RF	1
Bernert, JT; Blount, BC; McGuffey, JE; Morrow, JC; Wang, L; Wei, B; Xia, B	1
Borsotti, A; Castiglioni, S; Davoli, E; Senta, I; Zuccato, E	1
Alharbi, O; Goodacre, R; Xu, Y	1
Cela, R; Quintana, JB; Rico, M; Rodil, R; Rodríguez-Álvarez, T	1
Ferguson, SG; Jacobson, GA	1
Benowitz, NL; Cinciripini, P; George, TP; Hawk, LW; Heitjan, DF; Lerman, C; Schnoll, RA; Swan, GE; Tyndale, RF; Wileyto, EP	1
Aveyard, P; Coleman, T; Cooper, S; Leonardi-Bee, J; Vaz, LR	1
Chenoweth, MJ; Hamilton, DA; Hawk, LW; Heitjan, DF; Lerman, C; Mahoney, MC; Novalen, M; Tyndale, RF	1
Alexander, LA; Antonio, A; Cassel, KD; Clanton, MS; Fagan, P; Franke, AA; Herzog, T; Johnson, CA; Jorgensen, D; Kaholokula, JK; Kawamoto, C; Lynch, T; Moolchan, ET; Pagano, I; Pokhrel, P; Sakuma, KL; Sy, A; Trinidad, DR	1
DeVito, EE; Gelernter, J; Herman, AI; Jensen, KP; Sofuoglu, M; Valentine, GW	1
Benowitz, NL; Danaher, BG; Ebbert, JO; Schroeder, DR; Severson, HH	1
Alexander, LA; Clanton, MS; Fagan, P; Franke, AA; Herzog, TA; Johnson, CA; Moolchan, ET; Pagano, IS; Pokhrel, P; Sakuma, KL; Trinidad, DR	1
Benowitz, NL; Galanti, L; George, TP; Huestis, MA; Jatlow, P; Kankaanpää, A; Kaprio, J; Lerman, C; Murphy, SE; Novalen, M; Stefan, C; Tanner, JA; Tyndale, RF	1
Boulamery, A; Liachenko, N; Simon, N	1
Bowker, K; Coleman, T; Cooper, S; Lewis, S	1
Beatrice, F; Graziano, S; Massaro, G; Pacifici, R; Pellegrini, M; Pichini, S	1
Blazekovic, S; Gariti, P; Goelz, PM; Hitsman, B; Kaufmann, A; Leone, FT; Powers, L; Schnoll, RA; Tyndale, RF; Veluz-Wilkins, A	1
Hwang, SJ; Liu, KH	1
Benowitz, NL; Hoh, E; Hovell, MF; Jacob, P; Khan, AM; Matt, GE; Northrup, TF; Stotts, AL	1
Bernardo, L; Cao, W; Falcone, M; Lerman, C; Loughead, J; Tyndale, RF	1
Geyer, H; Hedeland, M; Piper, T; Schänzer, W; Thevis, M; Thomas, A; Tretzel, L	1
Bramness, JG; Castiglioni, S; Covaci, A; Gracia-Lor, E; Kinyua, J; Salvatore, S; Van Hal, G; van Nuijs, AL; van Wel, JH	1
De Cremer, KA; De Smedt, T; Dendale, P; Nackaerts, K; Van Laethem, DM; Van Loco, J; Van Overmeire, IP; Vanacker, H; Vanoeteren, JF	1
Aquilini, F; Breschi, MC; Carrozzi, L; Danesi, R; Del Re, M; Fogli, S; Palla, A; Pistelli, F; Saba, A; Zucchi, R	1
Cox, CM; Faulkner, P; Ghahremani, DG; Hellemann, GS; Kazanjian, AS; London, ED; Lotfipour, S; Paterson, N; Petersen, N; Tyndale, RF; Vigil, C	1
Choi, K; Donny, EC; Hatsukami, DK; Koopmeiners, JS; Murphy, SE; Raddatz, LM; Sipe, CJ	1
Cornuz, J; Csajka, C; Dobrinas, M; Eap, CB; Gholamrezaee, M; Glatard, A; Lubomirov, R	1
Been, F; Bruno, R; Carter, S; Gartner, C; Gerber, C; Hall, W; Kirkbride, KP; Lai, FY; Mueller, JF; O'Brien, J; Prichard, J; Thai, P; Tscharke, BJ; White, J	1
Covaci, A; Eaglesham, G; Gao, J; Jiang, G; Li, J; Mueller, JF; Thai, PK; Yuan, Z	1
Benowitz, NL; Delijewski, M; Goniewicz, ML; Kosmider, L; Koszowski, B; Sobczak, A	1
Chen, A; Krebs, NM; Muscat, JE; Zhu, J	1
Edstedt Bonamy, AK; Lundell, B; Nordenstam, F; Raaschou, P; Wickström, R	1
Chen, J; Halden, RU; Venkatesan, AK	1
Booth, GS; Gehrie, EA; Johnson-Davis, KL; Keiser, AM; Szklarski, PC; Wiencek, JR	1
Choi, PM; Gartner, CE; Mackie, RS; Mueller, JF; O'Brien, JW; Thomas, KV; Tscharke, BJ	1
Benowitz, NL; Cox, LS; Jacob, P; Nardone, N; St Helen, G	1
Chen, A; Krebs, NM; Machiorlatti, M; Muscat, JE	1
Addo, N; Ahluwalia, JS; Benowitz, NL; Cox, LS; Gregorich, SE; Pérez-Stable, EJ; St Helen, G; Tyndale, RF	1
Finel, M; Järvinen, E; Kidron, H; Koenderink, JB; Sjöstedt, N	1
Alexis, NE; Coakley, RD; Esther, CR; Ghio, AJ; Ghosh, A; Muhlebach, MS; Tarran, R	1
Arnold, LL; Cohen, SM; Kato, H; Naiki, T; Naiki-Ito, A; Pennington, KL; Suzuki, S; Takahashi, S; Yamashita, Y	1
Benowitz, NL; Carmella, SG; Carroll, DM; Dermody, SS; Donny, EC; Hatsukami, DK; Hecht, SS; Kotlyar, M; McClernon, FJ; Murphy, SE; Pacek, LR; Strasser, AA; Vandrey, RG	1
Flitter, A; Lerman, C; Schnoll, RA; Siegel, SD	1
Concheiro-Guisán, A; Concheiro-Guisán, M; Cruz, A; de-Castro-Ríos, A; González-Colmenero, E; Lendoiro, E; López-Rabuñal, Á; López-Rivadulla, M; Macias-Cortiña, M; Peñas-Silva, P	1
Cha, S; Cho, HD; Han, SB; Im, H; Jin, CH; Kim, J; Lee, E; Lee, JY; Suh, JH; Wang, Y	1
Abdelaziz, A; Bade, R; Gerber, C; Ghetia, M; Tscharke, BJ; White, JM	1
Burke, C; Marotta, PL; McKee, SA; Peltier, MR; Ramchandani, VA; Roberts, W; Verplaetse, TL	1
Chun, MR; Hwang, JH; Jee, JH; Lee, JY; Lee, SY; Oh, J; Park, MS	1
Han, W; Hashemi, S; Lee, C; Lim, Y; Song, Y; Yang, J	1
Akins, JR; Arnstein, S; Bernert, JT; Blount, BC; Borek, N; Caron, K; Conway, KP; de Castro, BR; Deng-Bryant, Y; Dortch, K; Edwards, KC; Feng, J; Goniewicz, ML; Hatsukami, DK; Hecht, SS; Hunter, RE; Hyland, A; Kimmel, HL; Lawrence, C; Li, Y; Mishina, E; Pine, BN; Pirkle, JL; Sosnoff, CS; van Bemmel, DM; Wang, L	1
Ahmad, SM; Hamid, A; Kanamori, K; Lutfy, K; Shin, CS	1

Reviews

2 review(s) available for nicotine and hydroxycotinine

Article	Year
Systematic review of the relationship between the 3-hydroxycotinine/cotinine ratio and cigarette dependence. Psychopharmacology, 2011, Volume: 218, Issue:2 Topics: Cotinine; Humans; Nicotine; Reproducibility of Results; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices; Tobacco Use Disorder	2011
The Use of the Nicotine Metabolite Ratio as a Biomarker to Personalize Smoking Cessation Treatment: Current Evidence and Future Directions. Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:3 Topics: Biomarkers; Cost-Benefit Analysis; Cotinine; Cytochrome P-450 CYP2A6; Electronic Nicotine Delivery Systems; Genetic Testing; Genetic Variation; Humans; Implementation Science; Metabolic Clearance Rate; Neoplasms; Nicotine; Precision Medicine; Prevalence; Smokers; Smoking; Smoking Cessation; Tobacco Use Cessation Devices	2020

Article

Year

Systematic review of the relationship between the 3-hydroxycotinine/cotinine ratio and cigarette dependence.

Psychopharmacology, 2011, Volume: 218, Issue:2

Topics: Cotinine; Humans; Nicotine; Reproducibility of Results; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Cessation Devices; Tobacco Use Disorder

2011

The Use of the Nicotine Metabolite Ratio as a Biomarker to Personalize Smoking Cessation Treatment: Current Evidence and Future Directions.

Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:3

Topics: Biomarkers; Cost-Benefit Analysis; Cotinine; Cytochrome P-450 CYP2A6; Electronic Nicotine Delivery Systems; Genetic Testing; Genetic Variation; Humans; Implementation Science; Metabolic Clearance Rate; Neoplasms; Nicotine; Precision Medicine; Prevalence; Smokers; Smoking; Smoking Cessation; Tobacco Use Cessation Devices

2020

Trials

18 trial(s) available for nicotine and hydroxycotinine

Article	Year
Sources of variability in nicotine and cotinine levels with use of nicotine nasal spray, transdermal nicotine, and cigarette smoking. British journal of clinical pharmacology, 1997, Volume: 43, Issue:3 Topics: Administration, Cutaneous; Administration, Inhalation; Adult; Analysis of Variance; Biological Availability; Cotinine; Drug Delivery Systems; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Regression Analysis; Smoking; Smoking Cessation	1997
A new gas chromatography-mass spectrometry method for simultaneous determination of total and free trans-3'-hydroxycotinine and cotinine in the urine of subjects receiving transdermal nicotine. Clinical chemistry, 1999, Volume: 45, Issue:1 Topics: Administration, Cutaneous; Cotinine; Gas Chromatography-Mass Spectrometry; Humans; Nicotine; Nicotinic Agonists; Sensitivity and Specificity; Smoking; Smoking Cessation	1999
Trans-3'-hydroxycotinine: disposition kinetics, effects and plasma levels during cigarette smoking. British journal of clinical pharmacology, 2001, Volume: 51, Issue:1 Topics: Adult; Affect; Cotinine; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Nicotine; Smoking; Tissue Distribution	2001
Nicotine metabolite ratio as a predictor of cigarette consumption. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003, Volume: 5, Issue:5 Topics: Adult; Biomarkers; Cotinine; Female; Ganglionic Stimulants; Humans; Male; Middle Aged; Nicotine; Predictive Value of Tests; Sensitivity and Specificity; Smoking; Tobacco Use Disorder	2003
Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation. Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:6 Topics: Administration, Cutaneous; Administration, Inhalation; Cotinine; Female; Humans; Liver; Male; Middle Aged; Nicotine; Smoking Cessation; Treatment Outcome	2006
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:5 Topics: Adolescent; Adult; Aged; Alleles; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Dose-Response Relationship, Drug; Ganglionic Stimulants; Gene Frequency; Glucuronides; Half-Life; Humans; Infusions, Intravenous; Isoenzymes; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Nicotine; Polymorphism, Genetic; Time Factors; Twins	2006
Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:5 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Citrus paradisi; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Female; Ganglionic Stimulants; Glucuronides; Half-Life; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Nicotine	2006
Population pharmacokinetics of nicotine and its metabolites I. Model development. Journal of pharmacokinetics and pharmacodynamics, 2007, Volume: 34, Issue:1 Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Biological Availability; Biotransformation; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Female; Half-Life; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Models, Biological; Models, Statistical; Nicotine; Nicotinic Agonists; Population Surveillance; Predictive Value of Tests; Reference Values; Saliva	2007
Identification of novel CYP2A61B variants: the CYP2A61B allele is associated with faster in vivo nicotine metabolism. Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:1 Topics: 3' Flanking Region; Aryl Hydrocarbon Hydroxylases; Base Sequence; Biotransformation; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Gene Frequency; Genetic Linkage; Genotype; Glucuronates; Humans; Infusions, Intravenous; Mixed Function Oxygenases; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Phenotype; Polymorphism, Genetic; Sequence Alignment; Substrate Specificity	2008
Respiratory retention of nicotine and urinary excretion of nicotine and its five major metabolites in adult male smokers. Toxicology letters, 2007, Sep-10, Volume: 173, Issue:2 Topics: Adult; Biomarkers; Biotransformation; Breath Tests; Chromatography, Liquid; Cotinine; Glucuronates; Half-Life; Humans; Inhalation; Lung; Male; Models, Biological; Nicotine; Nicotinic Agonists; Smoking; Tandem Mass Spectrometry	2007
Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers. Clinical pharmacology and therapeutics, 2009, Volume: 85, Issue:6 Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Black or African American; Body Mass Index; Cotinine; Cytochrome P-450 CYP2A6; Double-Blind Method; Female; Genotype; Humans; Male; Middle Aged; Nicotine; Polymorphism, Genetic; Smoking Cessation	2009
Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data. Trials, 2011, Jan-25, Volume: 12 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Black or African American; Bupropion; Cotinine; Counseling; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Female; Genotype; Health Behavior; Health Knowledge, Attitudes, Practice; Humans; Kansas; Male; Middle Aged; Motivation; Nicotine; Oxidoreductases, N-Demethylating; Patient Education as Topic; Patient Selection; Phenotype; Recurrence; Saliva; Smoking; Smoking Cessation; Smoking Prevention; Time Factors; Tobacco Use Disorder; Treatment Outcome	2011
Stability of the nicotine metabolite ratio in smokers of progressively reduced nicotine content cigarettes. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:11 Topics: Adult; Biomarkers; California; Cotinine; Female; Humans; Male; Middle Aged; Nicotine; Reproducibility of Results; Smoking; Tobacco Products	2013
Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014, Volume: 23, Issue:9 Topics: Cotinine; Cytochrome P-450 CYP2A6; Female; Genotype; Humans; Linear Models; Male; Middle Aged; Nicotine; Predictive Value of Tests; Smoking; Smoking Cessation; Tobacco Use Disorder	2014
Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial. The Lancet. Respiratory medicine, 2015, Volume: 3, Issue:2 Topics: Adult; Biomarkers; Cotinine; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Smoking Cessation; Tobacco Use Cessation Devices; Treatment Outcome; Varenicline	2015
The Nicotine Metabolite Ratio in Pregnancy Measured by trans-3'-Hydroxycotinine to Cotinine Ratio: Characteristics and Relationship With Smoking Cessation. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:11 Topics: Administration, Cutaneous; Adolescent; Adult; Cotinine; Female; Humans; Middle Aged; Nicotine; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Smoking; Smoking Cessation; Tobacco Use Disorder; Young Adult	2015
Test-Retest Reliability and Stability of the Nicotine Metabolite Ratio Among Treatment-Seeking Smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:12 Topics: Adult; Biomarkers; Cotinine; Female; Humans; Male; Middle Aged; Nicotine; Patient Acceptance of Health Care; Reproducibility of Results; Retrospective Studies; Smoking; Smoking Cessation; Tobacco Use Disorder; Treatment Outcome; Young Adult	2015
Nicotine Metabolite Ratio Is Associated With Lozenge Use But Not Quitting in Smokeless Tobacco Users. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016, Volume: 18, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Cotinine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nicotine; Saliva; Tobacco Use Cessation; Tobacco Use Cessation Devices; Tobacco Use Disorder; Tobacco, Smokeless; Young Adult	2016

Other Studies

135 other study(ies) available for nicotine and hydroxycotinine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Simultaneous determination of cotinine and trans-3'-hydroxycotinine in human serum by high-performance liquid chromatography. Journal of chromatography, 1992, Jun-10, Volume: 577, Issue:2 Topics: Chromatography, High Pressure Liquid; Cotinine; Humans; Nicotiana; Nicotine; Plants, Toxic; Smoking; Spectrophotometry, Ultraviolet	1992
Identification of cis-3'-hydroxycotinine as a urinary nicotine metabolite. Xenobiotica; the fate of foreign compounds in biological systems, 1990, Volume: 20, Issue:12 Topics: Animals; Chromatography, High Pressure Liquid; Cotinine; Cricetinae; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Injections, Intravenous; Male; Mesocricetus; Nicotine; Rats; Rats, Inbred Strains; Reference Standards; Smoking; Stereoisomerism	1990
Automation of a high-performance liquid chromatographic assay for the determination of nicotine, cotinine and 3-hydroxycotinine in human urine. Journal of pharmaceutical and biomedical analysis, 1990, Volume: 8, Issue:8-12 Topics: Autoanalysis; Chromatography, High Pressure Liquid; Cotinine; Humans; Nicotine; Quality Control; Reference Standards; Spectrophotometry, Ultraviolet	1990
Synthesis of (3'R,5'S)-trans-3'-hydroxycotinine, a major metabolite of nicotine. Metabolic formation of 3'-hydroxycotinine in humans is highly stereoselective. Journal of medicinal chemistry, 1990, Volume: 33, Issue:7 Topics: Biotransformation; Cotinine; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Nicotine; Pyrrolidinones; Smoking; Stereoisomerism	1990
Capillary gas chromatographic determination of trans-3'-hydroxycotinine simultaneously with nicotine and cotinine in urine and blood samples. Journal of chromatography, 1989, Oct-06, Volume: 479, Issue:2 Topics: Chromatography, Gas; Cotinine; Humans; Nicotine; Pyrrolidinones	1989
Enantioselective metabolism during continuous administration of S-(-)- and R-(+)-nicotine isomers to guinea-pigs. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:12 Topics: Animals; Biotransformation; Chromatography, Gas; Chromatography, High Pressure Liquid; Cotinine; Guinea Pigs; Male; Nicotine; Stereoisomerism; Time Factors	1988
Recent studies of nicotine metabolism in humans. Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:1 Topics: Adult; Cotinine; Deuterium; Humans; Infusions, Intravenous; Male; Nicotine; Smoking	1988
Trans-3'-hydroxycotinine--a main metabolite in smokers. Klinische Wochenschrift, 1988, Volume: 66 Suppl 11 Topics: Adult; Biotransformation; Cotinine; Dose-Response Relationship, Drug; Humans; Male; Nicotine; Pyrrolidinones; Smoking; Stereoisomerism	1988
Pharmacokinetics of nicotine, cotinine, and 3'-hydroxycotinine in cigarette smokers. Klinische Wochenschrift, 1988, Volume: 66 Suppl 11 Topics: Adult; Cotinine; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Mutagenicity Tests; Nicotine; Pyrrolidinones; Smoking	1988
Cotinine determination by immunoassays may be influenced by other nicotine metabolites. Archives of toxicology, 1988, Volume: 62, Issue:5 Topics: Animals; Buffers; Cotinine; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Nicotine; Pyrrolidinones; Rabbits	1988
Species variation and stereoselectivity in the metabolism of nicotine enantiomers. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:12 Topics: Animals; Cotinine; Cricetinae; Cyclic N-Oxides; Female; Guinea Pigs; Male; Mesocricetus; Nicotine; Rabbits; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Stereoisomerism	1988
Trans-3'-hydroxycotinine as a main metabolite in urine of smokers. International archives of occupational and environmental health, 1987, Volume: 59, Issue:2 Topics: Cotinine; Humans; Male; Nicotine; Pyrrolidinones; Smoking	1987
Gas chromatographic determination of trans-3'-hydroxycotinine, a major metabolite of nicotine in smokers. Journal of chromatography, 1987, Apr-10, Volume: 415, Issue:2 Topics: Chromatography, Gas; Cotinine; Humans; Mass Spectrometry; Nicotine; Pyrrolidinones; Smoking	1987
Structure of hydroxycotinine, a nicotine metabolite. Journal of medicinal chemistry, 1972, Volume: 15, Issue:4 Topics: Animals; Chromatography, Thin Layer; Cotinine; Haplorhini; Infrared Rays; Macaca; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Nicotine; Pyridines; Pyrrolidinones; Spectrum Analysis; Stereoisomerism	1972
The genotoxic potential of nicotine and its major metabolites. Mutation research, 1995, Volume: 344, Issue:3-4 Topics: Animals; CHO Cells; Cotinine; Cricetinae; Cyclic N-Oxides; Fluorenes; Mutagenicity Tests; Mutagens; Mutation; Nicotine; Salmonella typhimurium; Sister Chromatid Exchange	1995
Solid-phase extraction of nicotine and its metabolites for high-performance liquid chromatographic determination in urine. Journal of chromatography. B, Biomedical applications, 1995, Jun-09, Volume: 668, Issue:1 Topics: Chromatography, High Pressure Liquid; Cotinine; Humans; Nicotine; Smoking	1995
Reduction in nicotine intake and oral mucosal changes among users of Swedish oral moist snuff after switching to a low-nicotine product. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1995, Volume: 24, Issue:6 Topics: Adult; Cotinine; Cyclic N-Oxides; Glucuronates; Humans; Mouth Diseases; Mouth Mucosa; Nicotine; Plants, Toxic; Saliva; Sweden; Time Factors; Tobacco, Smokeless	1995
Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1994, Volume: 23, Issue:4 Topics: Adult; Cotinine; Glucuronates; Glucuronic Acid; Humans; Leukoedema, Oral; Male; Middle Aged; Mouth Diseases; Mouth Mucosa; Nicotine; Nitrosamines; Plants, Toxic; Saliva; Sweden; Tobacco, Smokeless	1994
Meconium analysis to assess fetal exposure to nicotine by active and passive maternal smoking. The Journal of pediatrics, 1994, Volume: 124, Issue:3 Topics: Cotinine; Female; Fetus; Humans; Maternal-Fetal Exchange; Meconium; Nicotine; Pregnancy; Smoking; Tobacco Smoke Pollution	1994
Nicotine, cotinine, and trans-3-hydroxycotinine levels in seminal plasma of smokers: effects on sperm parameters. Therapeutic drug monitoring, 1993, Volume: 15, Issue:5 Topics: Adolescent; Adult; Caffeine; Chromatography, High Pressure Liquid; Cotinine; Humans; Male; Middle Aged; Nicotine; Regression Analysis; Semen; Smoking; Spermatozoa	1993
Determination of nicotine and four metabolites in the serum of smokers by high-performance liquid chromatography with ultraviolet detection. Journal of chromatography, 1993, Nov-24, Volume: 621, Issue:2 Topics: Chromatography, High Pressure Liquid; Cotinine; Humans; Nicotine; Smoking	1993
Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:1 Topics: Administration, Cutaneous; Adult; Cotinine; Humans; Male; Middle Aged; Nicotiana; Nicotine; Plants, Toxic; Reference Values; Smoking	1994
Determination of nicotine and two major metabolites in serum by solid-phase extraction and high-performance liquid chromatography, and high-performance liquid chromatography-particle beam mass spectrometry. Journal of chromatography, 1993, Feb-26, Volume: 612, Issue:2 Topics: Chromatography, High Pressure Liquid; Cotinine; Humans; Mass Spectrometry; Nicotine; Reference Standards; Smoking; Spectrophotometry, Ultraviolet	1993
Determination of nicotine and its main metabolites in urine by high-performance liquid chromatography. Journal of chromatography, 1993, Feb-26, Volume: 612, Issue:2 Topics: Chromatography, High Pressure Liquid; Cotinine; Humans; Indicators and Reagents; Nicotine; Nicotinyl Alcohol; Smoking; Spectrophotometry, Ultraviolet	1993
Interference of nicotine metabolites in cotinine determination by RIA. Clinical chemistry, 1997, Volume: 43, Issue:1 Topics: Antibody Specificity; Cotinine; Humans; Immune Sera; Nicotine; Quality Control; Radioimmunoassay; Smoking	1997
The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1997, Volume: 26, Issue:3 Topics: Adult; Cotinine; Cyclic N-Oxides; Environmental Exposure; Glucuronates; Humans; Leukoedema, Oral; Leukoplakia, Oral; Male; Middle Aged; Mouth Diseases; Mouth Mucosa; Nicotiana; Nicotine; Plants, Toxic; Prevalence; Smoking; Tars; Time Factors; Tongue, Hairy	1997
Passive smoke exposure in infants and children with respiratory tract diseases. Human & experimental toxicology, 1999, Volume: 18, Issue:4 Topics: Adult; Age Factors; Biomarkers; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cotinine; Creatinine; Humans; Infant; Nicotine; Reproducibility of Results; Respiratory Tract Diseases; Saliva; Surveys and Questionnaires; Tobacco Smoke Pollution	1999
Analysis of nicotine, 3-hydroxycotinine, cotinine, and caffeine in urine of passive smokers by HPLC-tandem mass spectrometry. Clinical chemistry, 1999, Volume: 45, Issue:12 Topics: Caffeine; Chromatography, High Pressure Liquid; Cotinine; Finland; Food Industry; Humans; Mass Spectrometry; Nicotine; Occupational Exposure; Reproducibility of Results; Tobacco Smoke Pollution	1999
Effect of the nicotine metabolite 5'-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle. Pflugers Archiv : European journal of physiology, 1999, Volume: 439, Issue:1-2 Topics: Animals; Biological Transport, Active; Cotinine; Glucose; Glycogen Synthase; Hypoglycemic Agents; Insulin; Male; Muscle, Skeletal; Nicotine; Rats; Rats, Wistar	1999
Evidence for the biosynthesis of A glucuronide conjugate of (S)-(-)-nicotine, but not (S)-(-)-cotinine or (+/-)-trans-3'-hydroxycotinine by marmoset hepatic microsomes. Drug metabolism and drug interactions, 1999, Volume: 15, Issue:4 Topics: Animals; Callithrix; Chromatography, High Pressure Liquid; Cotinine; Glucuronates; Guinea Pigs; In Vitro Techniques; Male; Microsomes, Liver; Nicotine; Octoxynol; Rabbits; Rats; Rats, Wistar; Uridine Diphosphate Glucuronic Acid	1999
Nicotine metabolism and elimination kinetics in newborns. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Infant, Newborn; Male; Mixed Function Oxygenases; Nicotine; Prospective Studies	2000
Bacterial mutagenicity of some tobacco aromatic nitrogen bases and their mixtures. Mutation research, 2001, May-31, Volume: 492, Issue:1-2 Topics: Animals; Carcinogens; Cotinine; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nicotiana; Nicotine; Nitrosamines; Plants, Toxic; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Vibrio	2001
Effects of whole deletion of CYP2A6 on nicotine metabolism in humans. Drug and chemical toxicology, 2002, Volume: 25, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2A6; Gas Chromatography-Mass Spectrometry; Gene Deletion; Genotype; Homozygote; Humans; Mixed Function Oxygenases; Nicotine; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length	2002
Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles. Clinical chemistry, 2002, Volume: 48, Issue:9 Topics: Adult; Alkaloids; Anabasine; Cotinine; Female; Humans; Male; Mass Spectrometry; Middle Aged; Nicotiana; Nicotine; Reference Values; Substance Abuse Detection	2002
Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity. Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:1 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Saliva	2004
Simultaneous determination of nicotine, cotinine, norcotinine, and trans-3'-hydroxycotinine in human oral fluid using solid phase extraction and gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Jan-25, Volume: 814, Issue:2 Topics: Cotinine; Female; Gas Chromatography-Mass Spectrometry; Humans; Nicotine; Pregnancy; Reproducibility of Results; Saliva; Sensitivity and Specificity; Smoking	2005
Increased nicotine and cotinine levels in smokers with schizophrenia and schizoaffective disorder is not a metabolic effect. Schizophrenia research, 2005, Nov-15, Volume: 79, Issue:2-3 Topics: Adult; Cotinine; Demography; Female; Humans; Male; Middle Aged; Nicotine; Psychotic Disorders; Regression Analysis; Schizophrenia; Smoking	2005
A validated method for the determination of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in human plasma using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. Journal of mass spectrometry : JMS, 2006, Volume: 41, Issue:6 Topics: Atmospheric Pressure; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cotinine; Humans; Nicotine; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization	2006
Urinary nicotine and its metabolites as a biomarker of exposure to environmental tobacco smoke. Journal of UOEH, 2006, Sep-01, Volume: 28, Issue:3 Topics: Biomarkers; Cotinine; Humans; Nicotine; Time Factors; Tobacco Smoke Pollution	2006
A comparison of nicotine dose estimates in smokers between filter analysis, salivary cotinine, and urinary excretion of nicotine metabolites. Psychopharmacology, 2006, Volume: 189, Issue:3 Topics: Adult; Aged; Cotinine; Female; Filtration; Humans; Middle Aged; Nicotine; Nicotinic Agonists; Saliva; Smoking; Tars	2006
CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Volume: 15, Issue:10 Topics: Adolescent; Adult; Aged; Alleles; Analysis of Variance; Aryl Hydrocarbon Hydroxylases; Biomarkers; Breath Tests; Canada; Carbon Monoxide; Chromatography, High Pressure Liquid; Cotinine; Cytochrome P-450 CYP2A6; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Nicotinic Agonists; Phenotype; Polymerase Chain Reaction; Sensitivity and Specificity; Smoking; White People	2006
Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice. Molecular pharmacology, 2007, Volume: 71, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cotinine; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P450 Family 2; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mixed Function Oxygenases; Nicotine; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Species Specificity	2007
Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking. Drug and alcohol dependence, 2007, Jun-15, Volume: 89, Issue:1 Topics: Adolescent; Adult; Age Factors; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Black People; Cotinine; Cytochrome P-450 CYP2A6; Female; Genetic Variation; Humans; Male; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Nicotine; Reference Values; Sex Factors; Smoking	2007
Prediction methods for nicotine clearance using cotinine and 3-hydroxy-cotinine spot saliva samples II. Model application. Journal of pharmacokinetics and pharmacodynamics, 2007, Volume: 34, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Bayes Theorem; Biotransformation; Computer Simulation; Cotinine; Cytochrome P-450 CYP2A6; Humans; Liver; Metabolic Clearance Rate; Mixed Function Oxygenases; Models, Biological; Models, Statistical; Nicotine; Nicotinic Agonists; Predictive Value of Tests; Reproducibility of Results; Saliva; Smoking	2007
[Assessment of occurrence frequency of cotinine and trans-3'-hydroxycotinine in chosen body fluid samples]. Przeglad lekarski, 2006, Volume: 63, Issue:10 Topics: Amniotic Fluid; Body Fluids; Child; Chromatography, Thin Layer; Cotinine; Female; Humans; Infant; Infant, Newborn; Male; Nicotine; Pregnancy; Smoking; Tobacco Smoke Pollution	2006
Urine nicotine metabolites and smoking behavior in a multiracial/multiethnic national sample of young adults. American journal of epidemiology, 2007, Apr-15, Volume: 165, Issue:8 Topics: Adolescent; Cotinine; Female; Humans; Male; Nicotine; Smoking; Tobacco Use Disorder	2007
Sex-based and hormonal contraception effects on the metabolism of nicotine among adolescent tobacco-dependent smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2007, Volume: 9, Issue:4 Topics: Adolescent; Area Under Curve; Chromatography, Thin Layer; Cohort Studies; Contraceptives, Oral, Hormonal; Cotinine; Female; Humans; Male; Nicotine; Sex Factors; Smoking; Smoking Cessation	2007
CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:6 Topics: Administration, Cutaneous; Administration, Inhalation; Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2B6; Genotype; Humans; Linkage Disequilibrium; Nicotine; Nicotinic Agonists; Oxidoreductases, N-Demethylating; Smoking Cessation	2007
Assessment of prenatal tobacco smoke exposure by determining nicotine and its metabolites in meconium. Human & experimental toxicology, 2007, Volume: 26, Issue:6 Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cotinine; Data Interpretation, Statistical; Environmental Exposure; Female; Germany; Humans; Infant, Newborn; Maternal Exposure; Meconium; Nicotine; Pregnancy; Reproducibility of Results; Surveys and Questionnaires; Tobacco Smoke Pollution; Toxicology; Urinalysis	2007
Quantification of nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Feb-15, Volume: 863, Issue:1 Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Cotinine; Female; Humans; Indicators and Reagents; Infant, Newborn; Mass Spectrometry; Meconium; Nicotine; Pregnancy; Quality Control; Reference Standards; Smoking; Tandem Mass Spectrometry	2008
Stability of the nicotine metabolite ratio in ad libitum and reducing smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:6 Topics: Adult; Aged; Analysis of Variance; Cotinine; Female; Humans; Linear Models; Male; Middle Aged; Nicotine; Smoking; Smoking Cessation	2008
Nicotine metabolism in pregnant and nonpregnant rabbits. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2008, Volume: 10, Issue:8 Topics: Animals; Blotting, Western; Cotinine; Cytochrome P-450 CYP2D6; Female; Microsomes, Liver; Nicotine; Pregnancy; Pregnancy, Animal; Rabbits	2008
Studies on a simultaneous analytical method of urinary nicotine and its metabolites, and their half-lives in urine. Journal of UOEH, 2008, Sep-01, Volume: 30, Issue:3 Topics: Cotinine; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Nicotine; Smoking	2008
Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures. Clinical chemistry, 2008, Volume: 54, Issue:12 Topics: Apgar Score; Biomarkers; Body Size; Chromatography, Liquid; Cotinine; Female; Gestational Age; Glucuronates; Humans; Hydrolysis; Infant, Newborn; Maternal Exposure; Maternal-Fetal Exchange; Meconium; Nicotine; Pregnancy; Smoking; Tandem Mass Spectrometry; Tobacco Smoke Pollution	2008
Simultaneous and sensitive measurement of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Nov-01, Volume: 877, Issue:29 Topics: Chromatography, Liquid; Cotinine; Humans; Nicotine; Sensitivity and Specificity; Tandem Mass Spectrometry	2009
Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human oral fluid. Analytical and bioanalytical chemistry, 2009, Volume: 395, Issue:7 Topics: Chromatography, Liquid; Cotinine; Gingival Crevicular Fluid; Humans; Mass Spectrometry; Nicotine; Reproducibility of Results; Sensitivity and Specificity	2009
Quantitation of nicotine, its metabolites, and other related alkaloids in urine, serum, and plasma using LC-MS-MS. Methods in molecular biology (Clifton, N.J.), 2010, Volume: 603 Topics: Alkaloids; Anabasine; Chromatography, Liquid; Cotinine; Humans; Nicotine; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry	2010
Nicotine and its metabolites in amniotic fluid at birth--assessment of prenatal tobacco smoke exposure. Human & experimental toxicology, 2010, Volume: 29, Issue:5 Topics: Adolescent; Adult; Amniotic Fluid; Biomarkers; Chromatography, High Pressure Liquid; Cotinine; Female; Humans; Infant, Newborn; Maternal Exposure; Maternal-Fetal Exchange; Meconium; Nicotine; Pregnancy; Smoking; Young Adult	2010
[Development of analytical method for determination nicotine metabolites in urine]. Przeglad lekarski, 2009, Volume: 66, Issue:10 Topics: Biomarkers; Chromatography, High Pressure Liquid; Cotinine; Cyclic N-Oxides; Environmental Exposure; Environmental Monitoring; Humans; Nicotine; Predictive Value of Tests	2009
Relations between toxicity and altered tissue distribution and urinary excretion of nicotine, cotinine, and hydroxycotinine after chronic oral administration of nicotine in rats. Drug and chemical toxicology, 2010, Volume: 33, Issue:2 Topics: Animals; Aspartate Aminotransferases; Blood Chemical Analysis; Blood Urea Nitrogen; Brain; Cotinine; Ganglionic Stimulants; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Kidney; Liver; Male; Nicotine; Rats; Rats, Sprague-Dawley; Tissue Distribution	2010
Nicotine and metabolites in meconium as evidence of maternal cigarette smoking during pregnancy and predictors of neonatal growth deficits. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2010, Volume: 12, Issue:6 Topics: Adolescent; Adult; Chromatography, Liquid; Cotinine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meconium; Nicotine; Pregnancy; Pregnancy Trimesters; Smoking; Tandem Mass Spectrometry; Young Adult	2010
Estimation of nicotine dose after low-level exposure using plasma and urine nicotine metabolites. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:5 Topics: Adult; Biomarkers; Cotinine; Dose-Response Relationship, Drug; Female; Glucuronates; Humans; Male; Middle Aged; Nicotine; Smoking; Tobacco Smoke Pollution; Young Adult	2010
Chinese 'low-tar' cigarettes do not deliver lower levels of nicotine and carcinogens. Tobacco control, 2010, Volume: 19, Issue:5 Topics: Adult; Carcinogens; China; Consumer Product Safety; Cotinine; Humans; Male; Middle Aged; Nicotiana; Nicotine; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Smoking; Surveys and Questionnaires; Tars	2010
Carbamazepine but not valproate induces CYP2A6 activity in smokers with mental illness. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:10 Topics: Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Bipolar Disorder; Carbamazepine; Cotinine; Cytochrome P-450 CYP2A6; Enzyme Induction; Female; Humans; Male; Middle Aged; Nicotine; Oxcarbazepine; Schizophrenia; Smoking; Valproic Acid; Young Adult	2010
A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight. Environmental health : a global access science source, 2010, Aug-27, Volume: 9 Topics: Adult; Biomarkers; Birth Weight; Cohort Studies; Cotinine; Female; Humans; Infant, Newborn; Male; Maternal Exposure; Meconium; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Tobacco Smoke Pollution	2010
Nicotine and metabolites in paired umbilical cord tissue and meconium specimens. Therapeutic drug monitoring, 2011, Volume: 33, Issue:1 Topics: Anabasine; Central Nervous System Stimulants; Cotinine; Female; Humans; Infant, Newborn; Maternal Exposure; Maternal-Fetal Exchange; Meconium; Nicotine; Pregnancy; Smoking; Umbilical Cord	2011
Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011, Volume: 20, Issue:2 Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cotinine; Cytochrome P-450 CYP2A6; Female; Genotype; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Prognosis; Pyridines; Risk Assessment; Smoking; Survival Rate; Young Adult	2011
Measurement of nicotine, cotinine and trans-3'-hydroxycotinine in meconium by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Jul-15, Volume: 879, Issue:22 Topics: Biomarkers; Chromatography, Liquid; Cotinine; Drug Stability; Female; Humans; Hydroxides; Infant, Newborn; Linear Models; Maternal Exposure; Meconium; Nicotine; Potassium Compounds; Reproducibility of Results; Sensitivity and Specificity; Smoking; Solid Phase Extraction; Tandem Mass Spectrometry	2011
A one-year monitoring of nicotine use in sport: frontier between potential performance enhancement and addiction issues. Forensic science international, 2011, Dec-10, Volume: 213, Issue:1-3 Topics: Alkaloids; Anabasine; Athletes; Chromatography, Liquid; Cotinine; Doping in Sports; Humans; Mass Spectrometry; Nicotine; Performance-Enhancing Substances; Pyridines; Smoking; Spectrometry, Mass, Electrospray Ionization; Tobacco, Smokeless	2011
Oral fluid nicotine markers to assess smoking status and recency of use. Therapeutic drug monitoring, 2011, Volume: 33, Issue:5 Topics: Administration, Oral; Adult; Biomarkers; Cotinine; Female; Humans; Male; Middle Aged; Nicotine; Saliva; Smoking; Young Adult	2011
Quantification of nicotine, cotinine, trans-3'-hydroxycotinine and varenicline in human plasma by a sensitive and specific UPLC-tandem mass-spectrometry procedure for a clinical study on smoking cessation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Nov-15, Volume: 879, Issue:30 Topics: Benzazepines; Chromatography, High Pressure Liquid; Cotinine; Drug Stability; Humans; Linear Models; Nicotine; Quinoxalines; Reproducibility of Results; Sensitivity and Specificity; Smoking Cessation; Tandem Mass Spectrometry; Varenicline	2011
Determination of biomarkers of tobacco smoke exposure in oral fluid using solid-phase extraction and gas chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Mar-15, Volume: 889-890 Topics: Adolescent; Biomarkers; Child; Cotinine; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Nicotine; Reproducibility of Results; Saliva; Sensitivity and Specificity; Smoking; Solid Phase Extraction; Tobacco Smoke Pollution	2012
Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry. Clinica chimica acta; international journal of clinical chemistry, 2012, Jun-14, Volume: 413, Issue:11-12 Topics: Calibration; Chromatography, Liquid; Cotinine; Humans; Mecamylamine; Nicotine; Sensitivity and Specificity; Smoking; Smoking Cessation; Tandem Mass Spectrometry	2012
Exposure and kinetics of polycyclic aromatic hydrocarbons (PAHs) in cigarette smokers. Chemical research in toxicology, 2012, Apr-16, Volume: 25, Issue:4 Topics: Adolescent; Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Cotinine; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Kinetics; Male; Middle Aged; Nicotine; Nitrosamines; Poland; Polycyclic Aromatic Hydrocarbons; Pyridines; ROC Curve; Smoking; Tandem Mass Spectrometry; United States; Young Adult	2012
CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people. Pharmacogenetics and genomics, 2012, Volume: 22, Issue:6 Topics: Adult; Aged; Alaska; Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Epistasis, Genetic; Female; Gene Frequency; Genetic Association Studies; Genetic Variation; Genetics, Population; Genotype; Humans; Male; Middle Aged; Models, Genetic; Nicotine; Oxidoreductases, N-Demethylating; Population Groups; Smoking	2012
CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5'(1')iminium ion. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Chromatography, High Pressure Liquid; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Humans; Kinetics; NADP; Nicotiana; Nicotine; Nicotinic Agonists; Oxidation-Reduction; Tritium	2012
Nicotine intake and smoking topography in smokers with bipolar disorder. Bipolar disorders, 2012, Volume: 14, Issue:6 Topics: Adult; Antimanic Agents; Aryl Hydrocarbon Hydroxylases; Bipolar Disorder; Case-Control Studies; Cotinine; Cytochrome P-450 CYP2A6; Female; Ganglionic Stimulants; Humans; Male; Middle Aged; Nicotine; Schizophrenia; Smoking	2012
Prenatal tobacco exposure, biomarkers for tobacco in meconium, and neonatal growth outcomes. The Journal of pediatrics, 2013, Volume: 162, Issue:5 Topics: Adolescent; Adult; Biomarkers; Chromatography, Liquid; Cotinine; Female; Humans; Infant, Newborn; Longitudinal Studies; Maternal Exposure; Maternal-Fetal Exchange; Meconium; Nicotiana; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Smoking; Tandem Mass Spectrometry; Young Adult	2013
On-line solid-phase extraction with ultra performance liquid chromatography and tandem mass spectrometry for the detection of nicotine, cotinine and trans-3'-hydroxycotinine in urine to strengthen human biomonitoring and smoking cessation studies. Journal of pharmaceutical and biomedical analysis, 2013, Mar-25, Volume: 76 Topics: Chromatography, Liquid; Cotinine; Environmental Exposure; Humans; Nicotine; Reproducibility of Results; Sensitivity and Specificity; Smoking; Smoking Cessation; Solid Phase Extraction; Tandem Mass Spectrometry; Tobacco Smoke Pollution	2013
Biomarkers of secondhand smoke exposure in automobiles. Tobacco control, 2014, Volume: 23, Issue:1 Topics: Adolescent; Adult; Air Pollution, Indoor; Automobiles; Biomarkers; Carbon Monoxide; Cotinine; Environmental Exposure; Female; Humans; Male; Nicotiana; Nicotine; Nitrosamines; Particulate Matter; Pyridines; Smoking; Tobacco Smoke Pollution; Young Adult	2014
Simultaneous serum nicotine, cotinine, and trans-3'-hydroxycotinine quantitation with minimal sample volume for tobacco exposure status of solid organ transplant patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Jun-01, Volume: 928 Topics: Adult; Aged; Chromatography, High Pressure Liquid; Cotinine; Female; Humans; Limit of Detection; Male; Middle Aged; Nicotine; Organ Transplantation; Sample Size; Smoking; Tandem Mass Spectrometry; Time Factors	2013
Age-related differences in the disposition of nicotine and metabolites in rat brain and plasma. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013, Volume: 15, Issue:11 Topics: Administration, Cutaneous; Adolescent; Adult; Aging; Animals; Brain; Cotinine; Cyclic N-Oxides; Humans; Male; Nicotine; Rats; Rats, Sprague-Dawley	2013
Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. PloS one, 2013, Volume: 8, Issue:8 Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Black or African American; Cotinine; Cytochrome P-450 CYP2A6; Female; Gene Deletion; Genotype; Glucuronides; Glucuronosyltransferase; Humans; Male; Middle Aged; Minor Histocompatibility Antigens; Nicotine; Smoking; Young Adult	2013
Enhanced nicotine metabolism in HIV-1-positive smokers compared with HIV-negative smokers: simultaneous determination of nicotine and its four metabolites in their plasma using a simple and sensitive electrospray ionization liquid chromatography-tandem ma Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:2 Topics: Adult; Biotransformation; Cotinine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Reproducibility of Results; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Up-Regulation	2014
Clinical significance of early smoking withdrawal effects and their relationships with nicotine metabolism: preliminary results from a pilot study. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014, Volume: 16, Issue:5 Topics: Adult; Affect; Anxiety; Attention; Cotinine; Craving; Female; Heart Rate; Humans; Male; Middle Aged; Nicotine; Pilot Projects; Saliva; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder	2014
A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 68 Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Carboxyhemoglobin; Cell Differentiation; Chemokines; Cotinine; Cytokines; Endpoint Determination; Female; Inhalation Exposure; Lung; Male; Nicotiana; Nicotine; Organ Size; Rats; Rats, Sprague-Dawley; Respiratory Mucosa; Risk Assessment; Risk Factors; Tobacco Products; Transcriptome	2014
A comparison of nicotine biomarkers and smoking patterns in daily and nondaily smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014, Volume: 23, Issue:7 Topics: Adult; Biomarkers; Carbon Monoxide; Chromatography, Liquid; Cotinine; Female; Humans; Male; Mass Spectrometry; Nicotine; Smoking	2014
Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:9 Topics: Animals; Area Under Curve; Brain; Cotinine; Cyclic N-Oxides; Male; Models, Animal; Nicotine; Plasma; Rats; Rats, Wistar	2014
Validation of a LC-MS/MS method for quantifying urinary nicotine, six nicotine metabolites and the minor tobacco alkaloids--anatabine and anabasine--in smokers' urine. PloS one, 2014, Volume: 9, Issue:7 Topics: Alkaloids; Anabasine; Chromatography, Liquid; Cotinine; Humans; Nicotine; Pyridines; Smoking; Tandem Mass Spectrometry	2014
A novel approach for monitoring tobacco use in local communities by wastewater analysis. Tobacco control, 2015, Volume: 24, Issue:1 Topics: Cotinine; Humans; Italy; Nicotine; Population Surveillance; Residence Characteristics; Smoking; Tobacco Products; Wastewater	2015
Simultaneous multiplexed quantification of nicotine and its metabolites using surface enhanced Raman scattering. The Analyst, 2014, Oct-07, Volume: 139, Issue:19 Topics: Chemistry Techniques, Analytical; Cotinine; Hydrogen-Ion Concentration; Isomerism; Neural Networks, Computer; Nicotine; Spectrum Analysis, Raman	2014
Assessment of local tobacco consumption by liquid chromatography-tandem mass spectrometry sewage analysis of nicotine and its metabolites, cotinine and trans-3'-hydroxycotinine, after enzymatic deconjugation. Analytical chemistry, 2014, Oct-21, Volume: 86, Issue:20 Topics: Chemistry Techniques, Analytical; Chromatography, Liquid; Cotinine; Humans; Nicotine; Population Surveillance; Sewage; Spain; Tandem Mass Spectrometry; Tobacco Use	2014
Relationship between cotinine and trans-3'-hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2014, Volume: 19, Issue:8 Topics: Chromatography, Liquid; Cotinine; Female; Glucuronides; Glucuronosyltransferase; Humans; Male; Nicotine; Tandem Mass Spectrometry; White People	2014
Biomarkers of tobacco smoke exposure in racial/ethnic groups at high risk for lung cancer. American journal of public health, 2015, Volume: 105, Issue:6 Topics: Adolescent; Adult; Biomarkers; Cotinine; Female; Hawaii; Humans; Lung Neoplasms; Male; Mass Spectrometry; Native Hawaiian or Other Pacific Islander; Nicotine; Philippines; Risk; Saliva; Smoking; Translational Research, Biomedical; White People	2015
A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:12 Topics: Adult; Blood Pressure; Cognition Disorders; Cotinine; Female; Genome-Wide Association Study; Heart Rate; Humans; Male; Middle Aged; Nerve Tissue Proteins; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Polymorphism, Single Nucleotide; Receptors, Nicotinic; Smoking; Substance Withdrawal Syndrome; Surveys and Questionnaires	2015
Nicotine Metabolism in Young Adult Daily Menthol and Nonmenthol Smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016, Volume: 18, Issue:4 Topics: Adolescent; Adult; Biomarkers; Carbon Monoxide; Cotinine; Female; Humans; Male; Menthol; Nicotine; Saliva; Smoking; Tobacco Products; Young Adult	2016
Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, Volume: 24, Issue:8 Topics: Biomarkers; Cotinine; Humans; Nicotine	2015
Nicotine and metabolites determination in human plasma by ultra performance liquid chromatography-tandem mass spectrometry: a simple approach for solving contamination problem and clinical application. Fundamental & clinical pharmacology, 2015, Volume: 29, Issue:5 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Biotransformation; Calibration; Charcoal; Chromatography, Liquid; Cotinine; Female; Humans; Liquid-Liquid Extraction; Male; Middle Aged; Nicotine; Nicotinic Agonists; Reference Standards; Reproducibility of Results; Smoking Cessation; Tandem Mass Spectrometry; Tobacco Use Cessation Devices; Transdermal Patch; Young Adult	2015
Changes in the rate of nicotine metabolism across pregnancy: a longitudinal study. Addiction (Abingdon, England), 2015, Volume: 110, Issue:11 Topics: Adult; Chromatography, Liquid; Cotinine; Female; Humans; Longitudinal Studies; Multilevel Analysis; Nicotine; Postpartum Period; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Saliva; Smoking; Tandem Mass Spectrometry; United Kingdom; Young Adult	2015
Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study. International journal of environmental research and public health, 2015, Jul-08, Volume: 12, Issue:7 Topics: Adolescent; Adult; Biomarkers; Carbon Monoxide; Cotinine; Craving; Electronic Nicotine Delivery Systems; Female; Humans; Male; Middle Aged; Nicotine; Pilot Projects; Smoking; Smoking Cessation; Tobacco Use Disorder; Young Adult	2015
Rate of nicotine metabolism and smoking cessation outcomes in a community-based sample of treatment-seeking smokers. Addictive behaviors, 2015, Volume: 51 Topics: Administration, Cutaneous; Analysis of Variance; Anxiety; Biomarkers; Cotinine; Craving; Depression; Female; Humans; Male; Middle Aged; Nicotine; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder	2015
Effect of smoking cessation for 1 year on periodontal biomarkers in gingival crevicular fluid. Journal of periodontal research, 2016, Volume: 51, Issue:3 Topics: Adult; Biomarkers; Cotinine; Dental Plaque Index; Enzyme-Linked Immunosorbent Assay; Female; Gingival Crevicular Fluid; Humans; Interleukin-1beta; Male; Matrix Metalloproteinase 8; Matrix Metalloproteinase 9; Middle Aged; Nicotine; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontium; Prospective Studies; Saliva; Smoking; Smoking Cessation	2016
Thirdhand smoke contamination in hospital settings: assessing exposure risk for vulnerable paediatric patients. Tobacco control, 2016, Volume: 25, Issue:6 Topics: Carcinogens; Cotinine; Environmental Exposure; Environmental Monitoring; Female; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Nicotine; Nitrosamines; Pregnancy; Tobacco Smoke Pollution	2016
Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate. Biological psychiatry, 2016, 08-01, Volume: 80, Issue:3 Topics: Adolescent; Adult; Aged; Brain; Case-Control Studies; Cotinine; Cues; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nicotine; Saliva; Smoking; Young Adult	2016
Fully automated determination of nicotine and its major metabolites in whole blood by means of a DBS online-SPE LC-HR-MS/MS approach for sports drug testing. Journal of pharmaceutical and biomedical analysis, 2016, May-10, Volume: 123 Topics: Alkaloids; Anabasine; Automation; Chromatography, Liquid; Cotinine; Doping in Sports; Dried Blood Spot Testing; Electronic Nicotine Delivery Systems; Female; Humans; Male; Nicotine; Online Systems; Pyridines; Reproducibility of Results; Solid Phase Extraction; Sports; Substance Abuse Detection; Tandem Mass Spectrometry	2016
Investigation of agreement between wastewater-based epidemiology and survey data on alcohol and nicotine use in a community. Drug and alcohol dependence, 2016, May-01, Volume: 162 Topics: Adolescent; Adult; Aged; Alcohol Drinking; Belgium; Biomarkers; Chromatography, Liquid; Cities; Cotinine; Ethanol; Female; Humans; Male; Middle Aged; Nicotine; Residence Characteristics; Smoking; Sulfuric Acid Esters; Surveys and Questionnaires; Tandem Mass Spectrometry; Wastewater; Young Adult	2016
Nicotine Dependence and Urinary Nicotine, Cotinine and Hydroxycotinine Levels in Daily Smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016, Volume: 18, Issue:9 Topics: Adolescent; Adult; Biomarkers; Cotinine; Female; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Nicotine; Severity of Illness Index; Smoking; Smoking Cessation; Smoking Prevention; Surveys and Questionnaires; Tandem Mass Spectrometry; Tobacco Use Disorder; Young Adult	2016
Application of a pharmacokinetic/pharmacogenetic approach to assess the nicotine metabolic profile of smokers in the real-life setting. Journal of pharmaceutical and biomedical analysis, 2016, Nov-30, Volume: 131 Topics: Chromatography, Liquid; Cotinine; Cytochrome P-450 CYP2A6; Female; Genotype; Humans; Male; Nicotine; Polymerase Chain Reaction; Saliva; Sex Characteristics; Smoking; Tandem Mass Spectrometry	2016
Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:8 Topics: Adolescent; Adult; Affect; Attention; Consumer Behavior; Cotinine; Craving; Dose-Response Relationship, Drug; Female; Humans; Male; Nicotine; Smoking; Substance Withdrawal Syndrome; Young Adult	2017
Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017, Volume: 26, Issue:7 Topics: Adult; Biomarkers; Black or African American; Cotinine; Cytochrome P-450 CYP2A6; Female; Genetic Variation; Genotype; Glucuronides; Glucuronosyltransferase; Humans; Male; Middle Aged; Nicotine; Phenotype; Protein Isoforms; Randomized Controlled Trials as Topic; Renal Elimination; Saliva; Smokers; Smoking; United States; White People	2017
Association of nicotine metabolism and sex with relapse following varenicline and nicotine replacement therapy. Experimental and clinical psychopharmacology, 2017, Volume: 25, Issue:5 Topics: Adult; Cotinine; Cytochrome P-450 CYP2A6; Female; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Nicotine; Recurrence; Smoking; Smoking Cessation; Tobacco Products; Varenicline	2017
Measuring spatial and temporal trends of nicotine and alcohol consumption in Australia using wastewater-based epidemiology. Addiction (Abingdon, England), 2018, Volume: 113, Issue:6 Topics: Adolescent; Adult; Aged; Alcohol Drinking; Australia; Chromatography, Liquid; Cotinine; Ethanol; Female; Humans; Male; Middle Aged; Monte Carlo Method; Nicotine; Rural Population; Spatio-Temporal Analysis; Tandem Mass Spectrometry; Tobacco Use; Urban Population; Wastewater-Based Epidemiological Monitoring; Young Adult	2018
Stability of alcohol and tobacco consumption biomarkers in a real rising main sewer. Water research, 2018, 07-01, Volume: 138 Topics: Alcohol Drinking; Biomarkers; Cotinine; Ethanol; Glucuronates; Humans; Nicotine; Sulfuric Acid Esters; Tobacco Use; Wastewater; Water Pollutants, Chemical	2018
Slower nicotine metabolism among postmenopausal Polish smokers. Pharmacological reports : PR, 2018, Volume: 70, Issue:3 Topics: Adult; Chromatography, Liquid; Cotinine; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nicotine; Poland; Postmenopause; Smokers; Smoking; Tandem Mass Spectrometry	2018
Nicotine metabolite ratio predicts smoking topography: The Pennsylvania Adult Smoking Study. Drug and alcohol dependence, 2018, 09-01, Volume: 190 Topics: Adult; Cotinine; Female; Humans; Longitudinal Studies; Male; Middle Aged; Nicotine; Pennsylvania; Predictive Value of Tests; Saliva; Tobacco Products; Tobacco Smoking; Tobacco Use Disorder	2018
Snus users had high levels of nicotine, cotinine and 3-hydroxycotinine in their breastmilk, and the clearance was slower than in smoking mothers. Acta paediatrica (Oslo, Norway : 1992), 2019, Volume: 108, Issue:7 Topics: Adult; Case-Control Studies; Cohort Studies; Cotinine; Female; Humans; Infant; Milk, Human; Mothers; Nicotine; Smoking; Tobacco Use; Tobacco, Smokeless; Young Adult	2019
Alcohol and nicotine consumption trends in three U.S. communities determined by wastewater-based epidemiology. The Science of the total environment, 2019, Mar-15, Volume: 656 Topics: Alcohol Drinking; Chromatography, Liquid; Cotinine; Humans; Midwestern United States; New England; Nicotine; Seasons; Smoking; Sulfuric Acid Esters; Tandem Mass Spectrometry; Wastewater	2019
Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood. American journal of clinical pathology, 2019, 04-02, Volume: 151, Issue:5 Topics: Blood Banks; Chromatography, Liquid; Cotinine; Humans; Nicotine; Tandem Mass Spectrometry	2019
Trends in nicotine consumption between 2010 and 2017 in an Australian city using the wastewater-based epidemiology approach. Environment international, 2019, Volume: 125 Topics: Australia; Cities; Cotinine; Environmental Exposure; Humans; Nicotiana; Nicotine; Smoking; Wastewater	2019
Urine Metabolites for Estimating Daily Intake of Nicotine From Cigarette Smoking. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020, 02-06, Volume: 22, Issue:2 Topics: Adult; Biomarkers; Cigarette Smoking; Cotinine; Female; Humans; Male; Middle Aged; Nicotiana; Nicotine	2020
Socioeconomic differences in nicotine exposure and dependence in adult daily smokers. BMC public health, 2019, Apr-03, Volume: 19, Issue:1 Topics: Adult; Cotinine; Cross-Sectional Studies; Data Collection; Employment; Female; Humans; Income; Male; Middle Aged; Nicotine; Occupations; Pennsylvania; Saliva; Smoke; Smokers; Smoking; Social Class; Tobacco Products; Tobacco Use; Tobacco Use Disorder	2019
Black Light Smokers: How Nicotine Intake and Carcinogen Exposure Differ Across Various Biobehavioral Factors. Journal of the National Medical Association, 2019, Volume: 111, Issue:5 Topics: Adult; Age Factors; Aged; Biomarkers; Black or African American; Carcinogens; Cotinine; Female; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Sex Factors; Smoking; Tobacco Products; Tobacco Use Disorder; Young Adult	2019
Efflux transport of nicotine, cotinine and trans-3'-hydroxycotinine glucuronides by human hepatic transporters. Basic & clinical pharmacology & toxicology, 2019, Volume: 125, Issue:6 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cotinine; Glucuronides; Hepatocytes; Humans; Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Nicotine	2019
Chronic E-Cigarette Use Increases Neutrophil Elastase and Matrix Metalloprotease Levels in the Lung. American journal of respiratory and critical care medicine, 2019, 12-01, Volume: 200, Issue:11 Topics: Adult; Biomarkers; Bronchoalveolar Lavage Fluid; Cotinine; Female; Humans; Leukocyte Elastase; Lung; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Neutrophils; Nicotine; Vaping	2019
Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Toxicology, 2020, 01-15, Volume: 429 Topics: Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cotinine; Humans; Male; Nicotine; Nitrosamines; Rats; Rats, Inbred F344; Urinary Bladder; Urinary Bladder Neoplasms; Urothelium	2020
Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020, Volume: 29, Issue:4 Topics: Adult; Biomarkers; Cigarette Smoking; Cotinine; Cross-Sectional Studies; Datasets as Topic; Female; Humans; Inflammation; Longitudinal Studies; Male; Middle Aged; Nicotine; Randomized Controlled Trials as Topic; Self Report; Severity of Illness Index; Smokers; Tobacco Use Disorder; United States	2020
Assessment of Tobacco Exposure During Pregnancy by Meconium Analysis and Maternal Interview. Journal of analytical toxicology, 2020, Dec-12, Volume: 44, Issue:8 Topics: Chromatography, Liquid; Cotinine; Female; Humans; Infant, Newborn; Male; Mass Spectrometry; Maternal Exposure; Meconium; Nicotine; Pregnancy; Tobacco Smoke Pollution	2020
Analysis of Nicotine Metabolites in Hair and Nails Using QuEChERS Method Followed by Liquid Chromatography-Tandem Mass Spectrometry. Molecules (Basel, Switzerland), 2020, Apr-11, Volume: 25, Issue:8 Topics: Chromatography, Liquid; Cotinine; Hair; Humans; Limit of Detection; Nails; Nicotine; Solid Phase Extraction; Tandem Mass Spectrometry	2020
Anabasine-based measurement of cigarette consumption using wastewater analysis. Drug testing and analysis, 2020, Volume: 12, Issue:9 Topics: Alkaloids; Anabasine; Australia; Cigarette Smoking; Cotinine; Female; Humans; Male; Nicotine; Pyridines; Tobacco Products; Tobacco Use Cessation Devices; Wastewater	2020
A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States. Drug and alcohol dependence, 2020, 11-01, Volume: 216 Topics: Adult; Alcohol Drinking; Cotinine; Female; Humans; Longitudinal Studies; Male; Middle Aged; National Institute on Alcohol Abuse and Alcoholism (U.S.); Nicotiana; Nicotine; Prospective Studies; Risk Factors; Smokers; Tobacco Products; United States	2020
A Simple and High-Throughput LC-MS-MS Method for Simultaneous Measurement of Nicotine, Cotinine, 3-OH Cotinine, Nornicotine and Anabasine in Urine and Its Application in the General Korean Population. Journal of analytical toxicology, 2022, Feb-14, Volume: 46, Issue:1 Topics: Anabasine; Chromatography, Liquid; Cotinine; Humans; Nicotine; Republic of Korea; Tandem Mass Spectrometry	2022
Study on the daily Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021, Volume: 26, Issue:8 Topics: Adult; Aged; Asian People; Biomarkers; Chromatography, High Pressure Liquid; Cotinine; Female; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Republic of Korea; Smoke; Smokers; Smoking; Tandem Mass Spectrometry; Young Adult	2021
Serum Concentrations of Cotinine and Trans-3'-Hydroxycotinine in US Adults: Results From Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health Study. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2022, 03-26, Volume: 24, Issue:5 Topics: Adult; Biomarkers; Cotinine; Electronic Nicotine Delivery Systems; Humans; Nicotiana; Nicotine; Tobacco Use Disorder	2022
Identification of 5-Hydroxycotinine in the Plasma of Nicotine-Treated Mice: Implications for Cotinine Metabolism and Disposition in Vivo. Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:12 Topics: Animals; Biomarkers; Cotinine; Electronic Nicotine Delivery Systems; Female; Humans; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Nicotine; Oxides; Smoking; Tandem Mass Spectrometry	2022