nicotine has been researched along with haloperidol in 120 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (15.83) | 18.7374 |
| 1990's | 39 (32.50) | 18.2507 |
| 2000's | 39 (32.50) | 29.6817 |
| 2010's | 22 (18.33) | 24.3611 |
| 2020's | 1 (0.83) | 2.80 |
| Authors | Studies |
|---|---|
| Campbell, BG; Kimes, AS; London, ED; Scheffel, U; Wilson, AA | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Keserü, GM | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Giordanetto, F; Leach, AG; Zachariae, U | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Gunosewoyo, H; Kozikowski, AP; Yu, LF; Zhang, HK | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Al-Muhtasib, N; Brown, ML; Dakshanamurthy, S; Johnson, JE; Kellar, KJ; Kong, HS; Levin, ED; Liu, Y; Paige, M; Rezvani, AH; Sahibzada, N; Slade, S; Tomita, Y; Tran, T; Wells, C; Xiao, Y; Xie, T; Yenugonda, VM | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Cavalheiro, EA; Izquierdo, I | 1 |
| Flores, CM; Hornby, PJ; Hulihan-Giblin, BA; Kellar, KJ; Lumpkin, MD | 1 |
| Chuang, DM; Kirch, DG; Li, R; Wing, LL; Wyatt, RJ | 1 |
| Kita, T; Nakashima, T; Okamoto, M | 1 |
| Arevalo, E; Bronheim, S; Licamele, WL; Sonnenschein, K | 1 |
| Happe, HK; Murrin, LC | 1 |
| Rickards, EH | 1 |
| Cirino, P; Fogelson, MH; King, J; McConville, BJ; Norman, AB; Parker, KW; Sanberg, PR | 1 |
| Emerich, DF; Norman, AB; Sanberg, PR | 1 |
| Fogelson, MH; Klykylo, WM; Manderscheid, PZ; McConville, BJ; Norman, AB; Parker, KW; Sanberg, PR | 1 |
| Courtney, ND; Howlett, AC; Westfall, TC | 1 |
| Emerich, DF; McConville, BJ; Norman, AB; Sanberg, PR; Zanol, MD | 1 |
| Coen, KM; Corrigall, WA | 1 |
| Bigornia, L; Napp, D; Ryan, KA; Schneider, AS; Suozzo, M | 1 |
| Ikegami, H; Prasad, C; Spahn, SA | 1 |
| Haikala, H | 1 |
| Blythe, MM; Fogelson, HM; Klykylo, WM; Manderscheid, PZ; McConville, BJ; Norman, AB; Parker, KW; Sanberg, PR | 1 |
| Acquas, E; Carboni, E; Di Chiara, G; Frau, R | 1 |
| Fogelson, HM; Manderscheid, PZ; McConville, BJ; Norman, AB; Parker, KW; Sanberg, PR | 1 |
| Dalton, TK; Hunt, WA; Joseph, JA | 1 |
| Artalejo, AR; García, AG; González, MC; Hervás, PP; Montiel, C | 1 |
| Artalejo, AR; García, AG; Montiel, C; Sánchez-García, P | 1 |
| Zetler, G | 2 |
| Thörner, R; Zetler, G | 1 |
| Cheng, HC; Long, JP | 1 |
| Ueda, S | 1 |
| Graudenz, M; Izquierdo, I | 1 |
| Jones, RS; Olpe, HR; Steinmann, MW | 1 |
| Ellison, G; Nelson, L; Potthoff, AD | 1 |
| Allison, K; Arnold, B; Greenshaw, AJ; Ivanová, S; Paetsch, PR; Paslawski, T | 1 |
| Freudenreich, O; Levin, ED; McEvoy, JP; Rose, JE | 1 |
| Dawe, S; Gerada, C; Gray, JA; Russell, MA | 1 |
| Gray, JA; Joseph, MH; Peters, SL | 1 |
| Araki, Y; Furuno, K; Gomita, Y; Suemaru, K | 1 |
| Eyl, C; Hakan, RL; Hart, C | 1 |
| Gomita, Y; Oishi, R; Suemaru, K | 1 |
| Sanberg, PR; Silver, AA | 1 |
| Data, PG; Iturriaga, R; Morelli, L; Spergel, D | 1 |
| Cahill, DW; el-Etri, MM; Emerich, DF; Norman, AB; Sanberg, PR; Shipley, MT; Zanol, MD | 1 |
| Loh, EA; Roberts, DC; Smith, AM | 1 |
| Basso, MA; Evinger, C; Horn, AK; Manning, KA; Pellegrini, JJ; Sibony, PA | 1 |
| Levin, ED; Torry, D | 1 |
| Levin, ED; McEvoy, J; Rose, JE; Wilson, W | 1 |
| Erdmann, R | 1 |
| Dursun, SM; Reveley, MA | 1 |
| Burden, HW; Davis, MC; Hodson, CA | 1 |
| Frangou, S; Gray, JA; Lee, C; Russell, MA | 1 |
| Greenshaw, AJ; Ivanová, S | 1 |
| Levin, ED | 1 |
| Johnson, RG; Rose, GM; Stevens, KE | 1 |
| Bizot, JC | 1 |
| Buhusi, CV; Gray, JA; Schmajuk, NA | 1 |
| Elazar, Z; Paz, M | 1 |
| Cheng, JT; Duh, SL; Huang, CC; Kuo, DY; Liao, JM; Lin, TB | 1 |
| Berger, SP; Fox, L; Ho, LB; Reid, MS | 1 |
| Adams, CE; Breese, CR; Collins, AC; Gillen, KM; Lee, MJ; Leonard, S; Logel, J; Marks, MJ; Sullivan, B | 1 |
| Boye, SM; Clarke, PB | 1 |
| Breese, CR; Lee, MJ; Leonard, S; Strook, ML | 1 |
| Corsini, G; Fumagalli, F; Gennarelli, M; Maggio, R; Molteni, R; Racagni, G; Riva, M; Roceri, M | 1 |
| Kurasawa, M; Nakamura, K | 1 |
| Ross, BM; Seeman, M; Turenne, SD | 1 |
| Barrett, RJ; Caul, WF; Smith, RL; Stadler, JR | 1 |
| McConville, B; Philipp, MK; Sanberg, PR; Shytle, RD; Silver, AA; Wilkinson, BJ | 1 |
| Brauer, LH; Cramblett, MJ; Paxton, DA; Rose, JE | 1 |
| Caskey, NH; Eisenberger, NI; Huerta, L; Iwamoto-Schaap, PN; Jarvik, ME; Madsen, DC; Olmstead, RE; Terrace, SM; Wirshing, WC | 1 |
| Addy, N; Levin, ED | 1 |
| Kamaraju, L; McEvoy, JP; Nelson, L; Wilson, W; Yang, YK | 1 |
| Gould, TJ; Lewis, MC | 1 |
| Levin, ED; Rezvani, AH | 1 |
| Araki, H; Choshi, T; Gomita, Y; Hibino, S; Shibata, K; Suemaru, K; Umeda, K; Yasuda, K | 1 |
| Gray, JA; Larrauri, JA; Schmajuk, NA | 1 |
| Gur, RE; Kanes, SJ; Lerman, C; Liang, Y; Majumdar, S; Maxwell, CR; Siegel, SJ; Trief, DF | 1 |
| Hayslett, RL; Tizabi, Y | 1 |
| Cromwell, HC; Woodward, DJ | 1 |
| Harvey, I; Lilford, R; Song, F | 1 |
| Hikichi, H; Maehara, S; Ohta, H; Okuda, S; Satow, A | 1 |
| McClure, EA; Saulsgiver, KA; Wynne, CD | 1 |
| Bordia, T; McIntosh, JM; Quik, M | 1 |
| Boye, SM | 1 |
| Burke, D; Hall, BJ; Kutlu, MG; Levin, ED; Rose, JE; Slade, S | 1 |
| Akins, CK; Levi Bolin, B; Singleton, DL | 1 |
| Allenby, C; Hall, BJ; Kutlu, MG; Levin, ED; Slade, S | 1 |
| Burke, DA; Hall, BJ; Larrauri, JA; Levin, ED | 1 |
| Bordia, T; Perez, XA; Quik, M; Zhang, D | 1 |
| Feng, M; Li, M; Sparkman, NL; Sui, N | 1 |
| Miksys, S; Nobrega, JN; Remington, G; Tolledo, EC; Tyndale, RF; Wadji, FB | 1 |
| Avvisati, L; Buonaguro, EF; de Bartolomeis, A; Iasevoli, F; Latte, G; Marmo, F; Tomasetti, C | 1 |
| Abela, AR; Fletcher, PJ; Lê, AD; Li, Z | 1 |
| Arranz, B; Arrojo, M; Becoña, E; Bernardo, M; Castells, X; Cunill, R; Flórez, G; Fonseca, F; Garriga, M; Goikolea, JM; González-Pinto, A; López, A; Sáiz, PA; San, L; Tirado-Muñoz, J; Torrens, M; Zorrilla, I | 1 |
3 review(s) available for nicotine and haloperidol
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
[Nicotine in neuropsychiatric movement disorders].
Topics: Adult; Akathisia, Drug-Induced; Brain; Child; Dyskinesia, Drug-Induced; Haloperidol; Humans; Nicotine; Parkinson Disease; Receptors, Dopamine; Tourette Syndrome | 1996 |
Adjusted indirect comparison may be less biased than direct comparison for evaluating new pharmaceutical interventions.
Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Bias; Bupropion; Data Interpretation, Statistical; Drug Therapy; Fluoxetine; Haloperidol; Humans; Imipramine; Meta-Analysis as Topic; Nicotine; Randomized Controlled Trials as Topic; Risperidone; Schizophrenia; Smoking Cessation; Treatment Outcome | 2008 |
8 trial(s) available for nicotine and haloperidol
| Article | Year |
|---|---|
The effects of nicotine plus haloperidol compared to nicotine only and placebo nicotine only in reducing tic severity and frequency in Tourette's disorder.
Topics: Adolescent; Adult; Chewing Gum; Child; Drug Synergism; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Placebos; Polymethacrylic Acids; Polyvinyls; Psychiatric Status Rating Scales; Severity of Illness Index; Tobacco Use Cessation Devices; Tourette Syndrome; Videotape Recording | 1992 |
Nicotine intake in smokers increases following a single dose of haloperidol.
Topics: Adult; Haloperidol; Humans; Male; Nicotine; Reward; Self Administration; Smoking; Substance Withdrawal Syndrome | 1995 |
Nicotine-haloperidol interactions and cognitive performance in schizophrenics.
Topics: Adult; Antipsychotic Agents; Cognition; Drug Synergism; Female; Haloperidol; Humans; Male; Memory; Middle Aged; Nicotine; Nicotinic Agonists; Reaction Time; Schizophrenia | 1996 |
Effect of haloperidol on nicotine-induced enhancement of vigilance in human subjects.
Topics: Adolescent; Adult; Attention; Dopamine Antagonists; Double-Blind Method; Drug Interactions; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists | 1997 |
Transdermal nicotine and haloperidol in Tourette's disorder: a double-blind placebo-controlled study.
Topics: Administration, Cutaneous; Antipsychotic Agents; Cotinine; Double-Blind Method; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Haloperidol; Humans; Nicotine; Placebos; Psychiatric Status Rating Scales; Severity of Illness Index; Tourette Syndrome; Treatment Outcome | 2001 |
Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes.
Topics: Adolescent; Adult; Analysis of Variance; Dopamine Antagonists; Double-Blind Method; Female; Haloperidol; Humans; Male; Nicotine; Nicotinic Agonists; Smoking | 2001 |
Modulating tobacco smoking rates by dopaminergic stimulation and blockade.
Topics: Adolescent; Adult; Breath Tests; Bromocriptine; Carbon Dioxide; Cotinine; Dopamine Antagonists; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Surveys and Questionnaires; Tobacco Use Disorder | 2002 |
Nicotine decreases bradykinesia-rigidity in haloperidol-treated patients with schizophrenia.
Topics: Administration, Cutaneous; Adult; Anti-Dyskinesia Agents; Brain; Female; Haloperidol; Humans; Hypokinesia; Male; Middle Aged; Muscle Rigidity; Nicotine; Schizophrenia; Smoking | 2002 |
109 other study(ies) available for nicotine and haloperidol
| Article | Year |
|---|---|
Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Guanidines; Guinea Pigs; Iodobenzenes; Male; Mice; Receptors, sigma; Tissue Distribution | 1992 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design.
Topics: | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.
Topics: Azetidines; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; Humans; Ligands; Models, Molecular; Molecular Structure; Pyridines; Receptors, Nicotinic; Software; Structure-Activity Relationship | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Three main factors in rat shuttle behavior: their pharmacology and sequential entry in operation during a two-way avoidance session.
Topics: Animals; Apomorphine; Atropine; Atropine Derivatives; Avoidance Learning; Clonidine; Conditioning, Classical; Conditioning, Operant; Drive; Female; Haloperidol; Male; Nicotine; Phenoxybenzamine; Physostigmine; Rats | 1976 |
Partial characterization of a neurotransmitter pathway regulating the in vivo release of prolactin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bromocriptine; Haloperidol; Male; Mecamylamine; Methysergide; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Antagonists; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Nicotinic; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
Effects of chronic nicotine and haloperidol administration on muscarinic receptor-mediated phosphoinositide turnover in rat brain slices.
Topics: Animals; Brain Chemistry; Carbachol; Frontal Lobe; Haloperidol; Hippocampus; In Vitro Techniques; Male; Neostriatum; Nicotine; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic | 1992 |
[Nicotine-induced ambulatory stimulant effect and its reverse tolerance].
Topics: Animals; Drinking; Drug Tolerance; Haloperidol; Injections, Subcutaneous; Locomotion; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; Stimulation, Chemical | 1992 |
Nicotine gum in Tourette's disorder.
Topics: Chewing Gum; Drug Synergism; Drug Therapy, Combination; Haloperidol; Humans; Nicotine; Polymethacrylic Acids; Polyvinyls; Research Design; Tobacco Use Cessation Devices; Tourette Syndrome | 1992 |
High-affinity choline transport regulation by drug administration during postnatal development.
Topics: Animals; Animals, Newborn; Biological Transport; Cerebral Cortex; Choline; Corpus Striatum; Haloperidol; Hemicholinium 3; Injections, Intraperitoneal; Male; Nicotine; Pentobarbital; Postpartum Period; Rats; Rats, Inbred Strains; Tritium | 1992 |
Nicotine gum in Tourette's disorder.
Topics: Chewing Gum; Drug Therapy, Combination; Haloperidol; Humans; Nicotine; Polymethacrylic Acids; Polyvinyls; Tobacco Use Cessation Devices; Tourette Syndrome | 1992 |
Nicotine potentiates the behavioral effects of haloperidol.
Topics: Animals; Behavior, Animal; Catalepsy; Drug Synergism; Haloperidol; Male; Nicotine; Rats; Rats, Inbred Strains | 1991 |
Nicotine potentiation of haloperidol in reducing tic frequency in Tourette's disorder.
Topics: Adolescent; Adult; Chewing Gum; Child; Drug Synergism; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Tourette Syndrome | 1991 |
Dopaminergic regulation of dopamine release from PC12 cells via a pertussis toxin-sensitive G protein.
Topics: Adrenal Gland Neoplasms; Animals; Apomorphine; Cell Line; Dopamine; Dopamine Antagonists; Ergolines; GTP-Binding Proteins; Haloperidol; Nicotine; Pertussis Toxin; Pheochromocytoma; Potassium; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Virulence Factors, Bordetella | 1991 |
Nicotine potentiates haloperidol-induced catalepsy and locomotor hypoactivity.
Topics: Animals; Catalepsy; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Haloperidol; Humans; Male; Motor Activity; Nicotine; Rats; Rats, Inbred Strains; Tourette Syndrome | 1991 |
Selective dopamine antagonists reduce nicotine self-administration.
Topics: Animals; Benzazepines; Conditioning, Operant; Dopamine Antagonists; Food; Haloperidol; Male; Motor Activity; Nicotine; Rats; Reinforcement Schedule; Self Administration; Spiperone | 1991 |
Dopamine receptors on adrenal chromaffin cells modulate calcium uptake and catecholamine release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Animals; Apomorphine; Butaclamol; Calcium; Calcium Radioisotopes; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Electric Conductivity; Haloperidol; Ion Channels; Nicotine; Potassium; Receptors, Dopamine; Spiperone; Sulpiride | 1988 |
Chronic nicotine use blocks haloperidol-induced increase in striatal D2-dopamine receptor density.
Topics: Animals; Body Weight; Corpus Striatum; Dyskinesia, Drug-Induced; Eating; Haloperidol; Male; Nicotine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2 | 1989 |
Dual effects of nicotine on neuroleptic-induced changes of striatal dopamine metabolism in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Apomorphine; Body Temperature; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Male; Mice; Nicotine; Sodium Oxybate; Sulpiride | 1989 |
Nicotine potentiates the effects of haloperidol in animals and in patients with Tourette syndrome.
Topics: Adolescent; Animals; Behavior, Animal; Catalepsy; Chewing Gum; Child; Child, Preschool; Drug Interactions; Female; Haloperidol; Humans; Male; Nicotine; Rats; Rats, Inbred Strains; Tic Disorders; Tourette Syndrome | 1989 |
Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release.
Topics: Amphetamine; Animals; Brain Chemistry; Dialysis; Dopamine; Ethanol; Haloperidol; Indoles; Male; Morphine; Nicotine; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tropisetron | 1989 |
Nicotine gum and haloperidol in Tourette's syndrome.
Topics: Chewing Gum; Child; Haloperidol; Humans; Male; Nicotine; Polymethacrylic Acids; Polyvinyls; Tobacco Use Cessation Devices; Tourette Syndrome | 1988 |
Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence.
Topics: Aging; Animals; Bethanechol; Bethanechol Compounds; Carbachol; Cholinergic Fibers; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Nicotine; Oxotremorine; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Muscarinic | 1988 |
Characterization of a dopaminergic receptor that modulates adrenomedullary catecholamine release.
Topics: Adrenal Medulla; Animals; Apomorphine; Binding, Competitive; Catecholamines; Cattle; Cell Membrane; Haloperidol; Kinetics; Nicotine; Rats; Receptors, Dopamine; Spiperone | 1986 |
A dopaminergic receptor modulates catecholamine release from the cat adrenal gland.
Topics: Adrenal Glands; Adrenal Medulla; Animals; Apomorphine; Benzamides; Catecholamines; Cats; Dopamine; Female; Haloperidol; Male; Naloxone; Nicotine; Phentolamine; Receptors, Dopamine | 1985 |
Drug-induced catalepsy as influenced by convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Arecoline; Bemegride; Caffeine; Catalepsy; Central Nervous System Stimulants; Drug Synergism; Ethosuximide; Haloperidol; Humans; Lobeline; Male; Mice; Mice, Inbred Strains; Nicotine; Nikethamide; Paraoxon; Pentylenetetrazole; Pilocarpine; Tetrabenazine; Tremorine; Trifluoperazine | 1973 |
Anticataleptic actions of amantadine hydrochloride.
Topics: Amantadine; Animals; Aporphines; Body Temperature; Catalepsy; Central Nervous System; Drug Antagonism; Haloperidol; Humans; Male; Mice; Nicotine; Nitrophenols; Phosphates; Pilocarpine; Tetrabenazine; Trifluoperazine | 1970 |
Drug-induced catalepsy as influenced by psychostimulants, apomorphine, L-dopa, and yohimbine.
Topics: Amphetamine; Animals; Apomorphine; Catalepsy; Dihydroxyphenylalanine; Hallucinogens; Haloperidol; Humans; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Paraoxon; Pempidine; Phenmetrazine; Pilocarpine; Sparteine; Tetrabenazine; Trifluoperazine; Yohimbine | 1973 |
Dopaminergic nature of apomorphine-induced pecking in pigeons.
Topics: Animals; Apomorphine; Aporphines; Behavior, Animal; Chlorpromazine; Columbidae; Dihydroxyphenylalanine; Dioxoles; Dopamine; Haloperidol; Imipramine; Methyltyrosines; Nicotine; Oxotremorine; Phentolamine; Physostigmine; Pilocarpine; Propranolol; Receptors, Drug; Reserpine; Serotonin; Time Factors | 1974 |
[Pharmacological responses of the pyloric antrum strip of the rat stomach, with special reference to the mechanism of the contractions caused by serotonin and nicotine, relaxation of transmural stimulation and contraction and relaxation by tyramine].
Topics: Acetylcholine; Animals; Atropine; Barium; Bretylium Compounds; Cocaine; Depression, Chemical; Dibenzylchlorethamine; Haloperidol; In Vitro Techniques; Methysergide; Morphine; Muscle Contraction; Nicotine; Phenoxybenzamine; Physostigmine; Procaine; Propranolol; Pylorus; Rats; Receptors, Drug; Scopolamine; Serotonin; Stimulation, Chemical; Tyramine | 1971 |
Memory facilitation by naloxone is due to release of dopaminergic and beta-adrenergic systems from tonic inhibition.
Topics: Animals; Dextroamphetamine; Dopamine; Drug Interactions; Female; Haloperidol; Memory; Naloxone; Neural Inhibition; Nicotine; Phenoxybenzamine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Tolazoline | 1980 |
The locus coeruleus: actions of psychoactive drugs.
Topics: Action Potentials; Animals; Atropine; Caffeine; Chlorpromazine; Desipramine; Haloperidol; Locus Coeruleus; Male; Neurons; Nicotine; Norepinephrine; Physostigmine; Psychotropic Drugs; Rats; Scopolamine | 1983 |
Ethanol intake increases during continuous administration of amphetamine and nicotine, but not several other drugs.
Topics: Alcohol Drinking; Amphetamine; Animals; Caffeine; Drinking Behavior; Drug Implants; Female; Haloperidol; Lysergic Acid Diethylamide; Mescaline; Nicotine; Phencyclidine; Rats; Secobarbital | 1983 |
5HT3 receptor antagonists do not block nicotine induced hyperactivity in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Granisetron; Haloperidol; Indoles; Male; Motor Activity; Nicotine; Ondansetron; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Time Factors; Tropanes; Tropisetron | 1995 |
Haloperidol increases smoking in patients with schizophrenia.
Topics: Adult; Carbon Monoxide; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Schizophrenia; Smoking | 1995 |
Nicotine blocks latent inhibition in rats: evidence for a critical role of increased functional activity of dopamine in the mesolimbic system at conditioning rather than pre-exposure.
Topics: Acoustic Stimulation; Animals; Association Learning; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Electroshock; Haloperidol; Limbic System; Male; Nicotine; Rats; Rats, Sprague-Dawley | 1993 |
Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Dopamine Agents; Drug Synergism; Haloperidol; Male; Methamphetamine; Motor Activity; Nicotine; Rats; Rats, Wistar; Stereotyped Behavior | 1993 |
Specific neurophysiological effects of systemic nicotine on neurons in the nucleus accumbens.
Topics: Action Potentials; Animals; Dopamine; Electric Stimulation; Haloperidol; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Morphine; Naloxone; Neurons; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1993 |
Characteristics of tail-tremor induced by nicotine in rats.
Topics: Animals; Haloperidol; Hexamethonium; Male; Mecamylamine; Motor Activity; Nicotine; Oxotremorine; Rats; Rats, Wistar; Tail; Tremor | 1994 |
Transdermal nicotine patch and potentiation of haloperidol in Tourette's syndrome.
Topics: Administration, Cutaneous; Adolescent; Child; Drug Synergism; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Smoking; Tourette Syndrome | 1993 |
Effects of haloperidol on cat carotid body chemoreception in vitro.
Topics: Animals; Carbon Dioxide; Carotid Body; Cats; Chemoreceptor Cells; Dopamine; Haloperidol; Hypoxia; In Vitro Techniques; Nicotine; Oxygen; Partial Pressure; Perfusion; Sodium Cyanide | 1993 |
Nicotine potentiation of haloperidol-induced catalepsy: striatal mechanisms.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Catalepsy; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Synergism; Haloperidol; Homovanillic Acid; Male; Nicotine; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Evaluation of response perseveration of rats in the radial arm maze following reinforcing and nonreinforcing drugs.
Topics: Amphetamine; Animals; Food; Habituation, Psychophysiologic; Haloperidol; Heroin; Learning; Male; Nicotine; Rats; Rats, Wistar; Reinforcement, Psychology; Scopolamine | 1993 |
A role for the basal ganglia in nicotinic modulation of the blink reflex.
Topics: Anesthesia; Animals; Apomorphine; Basal Ganglia; Blinking; Chewing Gum; Decerebrate State; Electromyography; Haloperidol; Humans; Injections, Intravenous; Male; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Substantia Nigra; Trigeminal Nerve | 1993 |
Acute and chronic nicotine effects on working memory in aged rats.
Topics: Age Factors; Aging; Animals; Dose-Response Relationship, Drug; Haloperidol; Male; Maze Learning; Mecamylamine; Memory; Nicotine; Rats; Rats, Sprague-Dawley; Scopolamine | 1996 |
Differential effects of transdermal nicotine on microstructured analyses of tics in Tourette's syndrome: an open study.
Topics: Administration, Cutaneous; Adolescent; Adult; Haloperidol; Humans; Male; Middle Aged; Neurologic Examination; Nicotine; Receptors, Nicotinic; Tourette Syndrome; Treatment Failure | 1997 |
Effect of prior nicotine treatment on drug induced changes in serum LH concentrations in rats.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Gonadotropin-Releasing Hormone; Haloperidol; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1997 |
Nicotine-induced decreases in VTA electrical self-stimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron.
Topics: Animals; Conditioning, Operant; Dopamine Antagonists; Haloperidol; Male; Mecamylamine; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ondansetron; Rats; Rats, Sprague-Dawley; Scopolamine; Self Stimulation; Serotonin Antagonists; Ventral Tegmental Area | 1997 |
Chronic haloperidol administration does not block acute nicotine-induced improvements in radial-arm maze performance in the rat.
Topics: Animals; Cholinergic Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Implants; Female; Haloperidol; Maze Learning; Memory, Short-Term; Nicotine; Psychomotor Performance; Rats; Rats, Sprague-Dawley | 1997 |
Rats reared in social isolation show schizophrenia-like changes in auditory gating.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Evoked Potentials, Auditory; Haloperidol; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenic Psychology; Social Isolation | 1997 |
Effects of psychoactive drugs on temporal discrimination in rats.
Topics: Animals; Atropine; Clomipramine; Desipramine; Diazepam; Discrimination Learning; Discrimination, Psychological; Haloperidol; Male; Nicotine; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine | 1997 |
Psychopharmacology of latent inhibition: a neural network approach.
Topics: Amphetamine; Attention; Computer Simulation; Conditioning, Classical; Cues; Dopamine Agonists; Dopamine Antagonists; Flupenthixol; Haloperidol; Inhibition, Psychological; Neural Networks, Computer; Nicotine | 1998 |
Potentiation of haloperidol catalepsy by microinjections of nicotine into the striatum or pons in rats.
Topics: Animals; Catalepsy; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Male; Microinjections; Nicotine; Rats; Reticular Formation | 1999 |
Nicotine-induced hyperlocomotion is not modified by the estrous cycle, ovariectomy and estradiol replacement at physiological level.
Topics: Animals; Anti-Dyskinesia Agents; Estradiol; Estrus; Female; Ganglionic Stimulants; Haloperidol; Mecamylamine; Motor Activity; Nicotine; Nicotinic Antagonists; Ovariectomy; Ovary; Rats; Rats, Wistar | 1999 |
Nicotine stimulation of extracellular glutamate levels in the nucleus accumbens: neuropharmacological characterization.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Denervation; Dicarboxylic Acids; Dopamine; Extracellular Space; Glutamic Acid; Haloperidol; Kainic Acid; Kinetics; Male; Mecamylamine; Microdialysis; Neurotransmitter Uptake Inhibitors; Nicotine; Nucleus Accumbens; Oxidopamine; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2000 |
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia.
Topics: Aconitine; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Antipsychotic Agents; Brain; Bridged Bicyclo Compounds, Heterocyclic; Child; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Regression Analysis; Schizophrenia; Smoking | 2000 |
Enhancement of haloperidol-induced catalepsy by nicotine: an investigation of possible mechanisms.
Topics: Animals; Catalepsy; Chlorisondamine; Cotinine; Dopamine Antagonists; Drug Synergism; Haloperidol; Male; Mecamylamine; Nicotine; Rats; Rats, Sprague-Dawley | 2000 |
The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain.
Topics: Aconitine; Animals; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Antagonists; Haloperidol; Insecticides; Male; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Nicotinic; Schizophrenia; Smoking; Spiperone; Tritium | 2001 |
Stimulatory role of dopamine on fibroblast growth factor-2 expression in rat striatum.
Topics: Animals; Apomorphine; Benzazepines; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Fibroblast Growth Factor 2; Haloperidol; Male; Nicotine; Nicotinic Agonists; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stereoisomerism | 2001 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological | 2001 |
An animal model of nicotinic-acid-induced vasodilation: effect of haloperidol, caffeine and nicotine upon nicotinic acid response.
Topics: Animals; Antipsychotic Agents; Brain; Caffeine; Cerebrovascular Circulation; Disease Models, Animal; Haloperidol; Male; Niacin; Nicotine; Rats; Rats, Sprague-Dawley; Schizophrenia; Vasodilation | 2001 |
Long-lasting rebound cue effects following single doses of nicotine and amphetamine: implications for understanding tolerance.
Topics: Amphetamine; Animals; Cues; Discrimination, Psychological; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Tolerance; Haloperidol; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley | 2001 |
Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Female; Haloperidol; Maze Learning; Memory, Short-Term; Neural Pathways; Nicotine; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Dopamine; Risperidone; Schizophrenia | 2002 |
Nicotine and ethanol enhancements of acoustic startle reflex are mediated in part by dopamine in C57BL/6J mice.
Topics: Acoustic Stimulation; Animals; Dopamine; Dose-Response Relationship, Drug; Ethanol; Haloperidol; Mice; Mice, Inbred C57BL; Nicotine; Reflex, Startle | 2003 |
Nicotine-antipsychotic drug interactions and attentional performance in female rats.
Topics: Animals; Antipsychotic Agents; Attention; Central Nervous System Stimulants; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Female; Haloperidol; Nicotine; Photic Stimulation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Risperidone | 2004 |
Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic alpha7 receptors.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apomorphine; Central Nervous System; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Rats; Rats, Wistar; Receptors, Nicotinic; Reflex, Startle | 2004 |
A pre-clinical study showing how dopaminergic drugs administered during pre-exposure can impair or facilitate latent inhibition.
Topics: Computer Simulation; Conditioning, Classical; Dopamine Agonists; Drug Administration Schedule; Drug Evaluation, Preclinical; Haloperidol; Humans; Inhibition, Psychological; Models, Neurological; Nicotine; Psychopharmacology; Time Factors | 2005 |
Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials.
Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Bupropion; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Evoked Potentials, Auditory; Haloperidol; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Schizophrenia | 2005 |
Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome.
Topics: Amphetamines; Animals; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Frontal Lobe; Gene Expression; Haloperidol; Humans; Indans; Ketanserin; Male; Mesencephalon; Mice; Mice, Inbred ICR; Nicotine; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin Antagonists; Tourette Syndrome | 2005 |
Inhibitory gating of single unit activity in amygdala: effects of ketamine, haloperidol, or nicotine.
Topics: Acoustic Stimulation; Action Potentials; Amygdala; Animals; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Ketamine; Male; Neural Inhibition; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reflex, Startle | 2007 |
Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia.
Topics: Animals; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Hyperkinesis; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Oxotremorine; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenic Psychology | 2008 |
D-amphetamine, nicotine, and haloperidol produce similar disruptions in spatial and nonspatial temporal discrimination procedures.
Topics: Animals; Attention; Columbidae; Dextroamphetamine; Discrimination Learning; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Haloperidol; Nicotine; Nicotinic Agonists; Time Factors | 2011 |
Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats.
Topics: Animals; Antipsychotic Agents; Catalepsy; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Haloperidol; Male; Movement Disorders; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2012 |
Individual phenotype predicts nicotine-haloperidol interaction in catalepsy: possible implication for the therapeutic efficacy of nicotine in Tourette's syndrome.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Catalepsy; Drug Synergism; Environment; Haloperidol; Individuality; Male; Motor Activity; Nicotine; Nicotinic Agonists; Phenotype; Rats; Rats, Sprague-Dawley; Tourette Syndrome | 2013 |
Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats.
Topics: Animals; Benzazepines; Cerebral Cortex; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Nicotine; Nicotinic Agonists; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Self Administration; Time Factors; Tobacco Use Disorder | 2013 |
Pavlovian discriminative stimulus effects of methamphetamine in male Japanese quail (Coturnix japonica).
Topics: Animals; Benzazepines; Central Nervous System Stimulants; Cocaine; Conditioning, Classical; Coturnix; Discrimination, Psychological; Female; Generalization, Psychological; Haloperidol; Male; Methamphetamine; Nicotine; Receptors, Dopamine D1; Sexual Behavior, Animal | 2014 |
Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.
Topics: Animals; Benzazepines; Brain Mapping; Catheters, Indwelling; Cohort Studies; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Gyrus Cinguli; Haloperidol; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Parietal Lobe; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Self Administration; Tobacco Use Disorder | 2015 |
Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats.
Topics: Acoustic Stimulation; Amphetamine; Animals; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Female; Habenula; Haloperidol; Mecamylamine; Nicotine; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reflex, Startle; Sensory Gating | 2015 |
Striatal cholinergic interneurons and D2 receptor-expressing GABAergic medium spiny neurons regulate tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Channelrhodopsins; Choline O-Acetyltransferase; Cholinergic Neurons; Corpus Striatum; Disease Models, Animal; GABAergic Neurons; Gene Expression Regulation; Haloperidol; Male; Mastication; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Dopamine D2; Tardive Dyskinesia | 2016 |
A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Conditioning, Classical; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Schizophrenia | 2017 |
Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms.
Topics: Animals; Brain; Catalepsy; Cytochrome P450 Family 2; Haloperidol; Liver; Male; Microinjections; Nicotine; Propranolol; Rats; Tardive Dyskinesia | 2017 |
Nicotine and caffeine modulate haloperidol-induced changes in postsynaptic density transcripts expression: Translational insights in psychosis therapy and treatment resistance.
Topics: Animals; Brain; Caffeine; Central Nervous System Agents; Cytoskeletal Proteins; Drug Interactions; Drug Resistance; Gene Expression; Haloperidol; Homer Scaffolding Proteins; Male; Motor Activity; Nerve Tissue Proteins; Nicotine; Post-Synaptic Density; Psychotic Disorders; Random Allocation; Rats, Sprague-Dawley; RNA, Messenger; Schizophrenia | 2018 |
Clozapine reduces nicotine self-administration, blunts reinstatement of nicotine-seeking but increases responding for food.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Conditioning, Operant; Drug-Seeking Behavior; Food; Haloperidol; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Reward; Self Administration | 2019 |
Clinical practice guideline on pharmacological and psychological management of adult patients with schizophrenia spectrum disorders and a comorbid substance use.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Haloperidol; Humans; Nicotine; Olanzapine; Practice Guidelines as Topic; Schizophrenia; Substance-Related Disorders | 2022 |