nicotine has been researched along with flumazenil in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Farde, L; Nybäck, H; Pauli, S; Persson, A; Savic, I; Sedvall, G; Wiesel, FA | 1 |
| Garcha, HS; Rose, IC; Stolerman, IP | 1 |
| Norris, EA; Rauch, RJ; Stolerman, IP | 1 |
| Brioni, JD; O'Neill, AB | 1 |
| Mariathasan, EA; Stolerman, IP; White, JA | 1 |
| Iida, Y; Kitano, H; Konishi, J; Magata, Y; Nishizawa, S; Saji, H; Shiozaki, T | 1 |
| Bois, F; Cosgrove, KP; Esterlis, I; Kirk, K; Krishnan-Sarin, S; Lee, D; McKee, SA; O'Malley, SS; Seibyl, JP; Staley, JK; Stiklus, SM | 1 |
| Gruca, P; Lason-Tyburkiewicz, M; Litwa, E; Papp, M; Willner, P | 1 |
| Bois, F; Carson, RE; Cosgrove, KP; Esterlis, I; Glahn, DC; Kloczynski, T; Krystal, JH; Lancaster, J; McKay, R; O'Malley, S; Perkins, E; Pittman, B | 1 |
1 review(s) available for nicotine and flumazenil
| Article | Year |
|---|---|
Recent advances in psychiatric brain imaging.
Topics: Benzazepines; Brain Chemistry; Carbon Radioisotopes; Flumazenil; Humans; Nicotine; Raclopride; Receptors, Dopamine; Receptors, GABA-A; Receptors, Nicotinic; Salicylamides; Tomography, Emission-Computed | 1990 |
20 other study(ies) available for nicotine and flumazenil
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Midazolam cue in rats: effects of Ro 15-1788 and picrotoxin.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Male; Midazolam; Nicotine; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A | 1986 |
Discriminative stimulus effects of a nicotine-midazolam mixture in rats.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Male; Mecamylamine; Midazolam; Nicotine; Rats | 1987 |
Benzodiazepine receptor mediation of the anxiolytic-like effect of (-)-nicotine in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Flumazenil; Male; Mecamylamine; Mice; Nicotine; Receptors, GABA-A; Receptors, Nicotinic | 1994 |
Antagonism of AND and AND-OR drug mixture discriminations in rats.
Topics: Animals; Anti-Anxiety Agents; Association Learning; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Flumazenil; GABA Modulators; Mecamylamine; Midazolam; Motivation; Nicotine; Nicotinic Antagonists; Rats; Reinforcement Schedule; Substance-Related Disorders | 1997 |
Effect of chronic (-)-nicotine treatment on rat cerebral benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Flumazenil; Iodine Radioisotopes; Male; Nicotine; Nicotinic Agonists; Radionuclide Imaging; Rats; Rats, Wistar; Receptors, GABA-A; Tissue Distribution | 2000 |
Sex-specific differences in GABA(A) -benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving.
Topics: Adult; Affective Symptoms; Analysis of Variance; Animals; Brain; Female; Flumazenil; GABA Modulators; Humans; Male; Middle Aged; Nicotine; Pain Perception; Receptors, GABA-A; Sex Characteristics; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tomography, Emission-Computed, Single-Photon; Young Adult | 2013 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumazenil; GABA Modulators; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Stress, Psychological; Substance Withdrawal Syndrome; Substance-Related Disorders | 2014 |
Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.
Topics: Analysis of Variance; Animals; Carbon Radioisotopes; Craving; Female; Flumazenil; Humans; Iodine Radioisotopes; Macaca mulatta; Male; Nicotine; Positron-Emission Tomography; Receptors, GABA-A; Smoking; Substance Withdrawal Syndrome; Tomography, Emission-Computed, Single-Photon | 2014 |