Page last updated: 2024-08-26

nicotine and deuterium

nicotine has been researched along with deuterium in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (24.24)	18.7374
1990's	10 (30.30)	18.2507
2000's	11 (33.33)	29.6817
2010's	4 (12.12)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chen, CH; Fung, PT; Hecht, SS	1
Britton, G; Goodwin, TW; Lockley, WJ; Patel, NJ	1
Copeland, J; Everly, J; Gargus, JL; Habermann, RT; Sullivan, JB	1
James, B; Todd, MM; Verhaegen, MJ; Warner, DS; Weeks, JB	1
Benowitz, NL; Jacob, P; Wilson, M; Yu, L	1
Benowitz, NL; Chan, K; Denaro, CP; Jacob, P	1
Benowitz, NL; Denaro, C; Jacob, P; Jenkins, R	1
Benowitz, NL; Jacob, P; Shulgin, AT	1
Castagnoli, N; Peterson, LA; Trevor, A	1
Priest, WC; Sabelli, HC	1
Bernstein, J; Poisner, AM	1
Craig, JC; Kumler, WD; Simpson, TR	1
Benowitz, NL; Jacob, P	2
Benowitz, NL; Jacob, P; Le Houezec, J	1
Alexoff, D; Cilento, R; Fowler, JS; Logan, J; MacGregor, R; Pappas, N; Volkow, ND; Wang, GJ; Warner, D; Wolf, AP; Zezulkova, I	1
Benowitz, NL; Herrera, B; Jacob, P; Pérez-Stable, EJ	1
Anderson, RW; Baskin, LB; Charlson, JR; Hurt, RD; Lawson, GM	1
Benowitz, NL; Gourlay, SG; Hukkanen, J; Kenkare, S	1
Benowitz, NL; Jacob, P; Lessov-Schlaggar, CN; Swan, GE	1
Benowitz, NL; Jacob, P; Lessov-Schlaggar, CN; Swan, GE; Tyndale, RF	1
Benowitz, NL; Hukkanen, J; Jacob, P	1
Benowitz, NL; Dempsey, DA; Levi, M; Sheiner, LB	1
Hatton, W; Kwiecień, RA; Lebreton, J; Molinié, R; Paneth, P; Robins, RJ	1
Benowitz, NL; Krasnow, RE; Lessov-Schlaggar, CN; Mwenifumbo, JC; Swan, GE; Tyndale, RF; Zhou, Q	1
Ho, SW; Murphy, SE; Villalta, P; von Weymarn, LB	1
Andrews, JA; Benowitz, N; Bergen, AW; He, Y; Hops, H; Lessov-Schlaggar, CN; Swan, GE; Tildesley, E; Webster, C	1
Binette, MJ; Lafontaine, P; Ng, LK; Vanier, M	1
Albertino, A; Mesnard, F; Molinie, R; Qi, H; Sauer, PE; Schimmelmann, A	1
Fu, X; Ling, JJ; Qin, ZH; Wu, XJ; Zhang, YF	1
Bawazeer, S; Knottenbelt, C; Watson, DG	1
Fu, X; Ling, J; Wu, X	1
Alizadeh, E; Li, Z; Ptasińska, S; Ryszka, M	1

Trials

5 trial(s) available for nicotine and deuterium

Article	Year
Female sex and oral contraceptive use accelerate nicotine metabolism. Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:5 Topics: Adolescent; Adult; Aged; Area Under Curve; Cohort Studies; Contraceptives, Oral, Hormonal; Cotinine; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Menopause; Metabolic Clearance Rate; Middle Aged; Nicotine; Sex Factors; Smoking; Twins	2006
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:5 Topics: Adolescent; Adult; Aged; Alleles; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Dose-Response Relationship, Drug; Ganglionic Stimulants; Gene Frequency; Glucuronides; Half-Life; Humans; Infusions, Intravenous; Isoenzymes; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Nicotine; Polymorphism, Genetic; Time Factors; Twins	2006
Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance. Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:5 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Citrus paradisi; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Female; Ganglionic Stimulants; Glucuronides; Half-Life; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Nicotine	2006
Population pharmacokinetics of nicotine and its metabolites I. Model development. Journal of pharmacokinetics and pharmacodynamics, 2007, Volume: 34, Issue:1 Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Biological Availability; Biotransformation; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Female; Half-Life; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Mixed Function Oxygenases; Models, Biological; Models, Statistical; Nicotine; Nicotinic Agonists; Population Surveillance; Predictive Value of Tests; Reference Values; Saliva	2007
Identification of novel CYP2A61B variants: the CYP2A61B allele is associated with faster in vivo nicotine metabolism. Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:1 Topics: 3' Flanking Region; Aryl Hydrocarbon Hydroxylases; Base Sequence; Biotransformation; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Gene Frequency; Genetic Linkage; Genotype; Glucuronates; Humans; Infusions, Intravenous; Mixed Function Oxygenases; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Phenotype; Polymorphism, Genetic; Sequence Alignment; Substrate Specificity	2008

Other Studies

28 other study(ies) available for nicotine and deuterium

Article	Year
Assay for microsomal alpha-hydroxylation of N'-nitrosonornicotine and determination of the deuterium isotope effect for alpha-hydroxylation. Cancer research, 1979, Volume: 39, Issue:12 Topics: Animals; Aroclors; Deuterium; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nicotine; Nitrosamines; Rats	1979
The use of deuterium from deuterium oxide as a label in studies of biosynthetic pathways: carotenoid transformations in a Flavobacterium species. FEBS letters, 1977, Jul-15, Volume: 79, Issue:2 Topics: Carotenoids; Deuterium; Flavobacterium; Mass Spectrometry; Nicotine	1977
Mouse dermal study of smoke condensate from "Chemosol"-treated cigarettes. Toxicology and applied pharmacology, 1975, Volume: 33, Issue:3 Topics: Animals; Benzopyrenes; Citrates; Citric Acid; Deuterium; Deuterium Oxide; Female; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Nicotiana; Nicotine; Plants, Toxic; Skin Neoplasms; Smoke; Smoking	1975
The role of electrode size on the incidence of spreading depression and on cortical cerebral blood flow as measured by H2 clearance. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1992, Volume: 12, Issue:2 Topics: Animals; Blood Flow Velocity; Cerebrovascular Circulation; Cortical Spreading Depression; Deuterium; Electrodes; Nicotine; Parietal Lobe; Prostheses and Implants; Rats; Rats, Inbred Strains	1992
Selected ion monitoring method for determination of nicotine, cotinine and deuterium-labeled analogs: absence of an isotope effect in the clearance of (S)-nicotine-3',3'-d2 in humans. Biological mass spectrometry, 1991, Volume: 20, Issue:5 Topics: Adult; Cotinine; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Nicotine; Smoking	1991
Stable isotope method for studying transdermal drug absorption: the nicotine patch. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:3 Topics: Administration, Cutaneous; Adult; Biological Availability; Deuterium; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Nicotine; Skin Absorption; Smoking; Substance Withdrawal Syndrome	1991
Stable isotope studies of nicotine kinetics and bioavailability. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:3 Topics: Administration, Inhalation; Administration, Oral; Adult; Biological Availability; Deuterium; Humans; Infusions, Intravenous; Male; Middle Aged; Nicotine; Smoking	1991
Recent studies of nicotine metabolism in humans. Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:1 Topics: Adult; Cotinine; Deuterium; Humans; Infusions, Intravenous; Male; Nicotine; Smoking	1988
Stereochemical studies on the cytochrome P-450 catalyzed oxidation of (S)-nicotine to the (S)-nicotine delta 1'(5')-iminium species. Journal of medicinal chemistry, 1987, Volume: 30, Issue:2 Topics: Animals; Cytochrome P-450 Enzyme System; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Magnetic Resonance Spectroscopy; Microsomes, Liver; Nicotine; Rabbits; Structure-Activity Relationship	1987
Water structure in anesthetic action: time-dependence D2O effects on nerve. Arzneimittel-Forschung, 1970, Volume: 20, Issue:1 Topics: Action Potentials; Anesthesia; Anesthetics; Anesthetics, Local; Animals; Anura; Calcium; Cocaine; Depression, Chemical; Deuterium; Ethanol; Ethyl Ethers; Glucose; In Vitro Techniques; Lidocaine; Models, Biological; Neural Conduction; Nicotine; Ouabain; Oxides; Phosphates; Procaine; Sciatic Nerve; Stimulation, Chemical; Temperature; Time Factors; Water	1970
A possible role of microtubules in catecholamine release from the adrenal medulla: effect of colchicine, vinca alkaloids and deuterium oxide. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 177, Issue:1 Topics: Acetylcholine; Adrenal Medulla; Animals; Catecholamines; Cattle; Chromaffin System; Colchicine; Depression, Chemical; Deuterium; Drug Synergism; In Vitro Techniques; Microtubules; Nicotine; Organoids; Perfusion; Time Factors; Vinblastine; Vincristine	1971
Determination of the conformation of nicotine and some related compounds by nuclear magnetic resonance and dipole moments. Journal of pharmaceutical sciences, 1967, Volume: 56, Issue:6 Topics: Deuterium; Magnetic Resonance Spectroscopy; Nicotine; Protons; Pyrrolidines	1967
Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:5 Topics: Adult; Cotinine; Deuterium; Female; Humans; Male; Middle Aged; Nicotine; Oxidation-Reduction; Smoking	1994
Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers. Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:3 Topics: Adult; Cotinine; Deuterium; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Nicotine; Regression Analysis; Smoking	1993
A clinical pharmacological study of subcutaneous nicotine. European journal of clinical pharmacology, 1993, Volume: 44, Issue:3 Topics: Adult; Aged; Biological Availability; Blood Pressure; Deuterium; Heart Rate; Humans; Injections, Subcutaneous; Male; Metabolic Clearance Rate; Middle Aged; Nicotine; Smoking; Surveys and Questionnaires	1993
Neuropharmacological actions of cigarette smoke: brain monoamine oxidase B (MAO B) inhibition. Journal of addictive diseases, 1998, Volume: 17, Issue:1 Topics: Adult; Basal Ganglia; Brain; Carbon Radioisotopes; Deuterium; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nicotine; Selegiline; Smoke; Smoking; Tomography, Emission-Computed	1998
Nicotine metabolism and intake in black and white smokers. JAMA, 1998, Jul-08, Volume: 280, Issue:2 Topics: Adult; Area Under Curve; Black People; Chromatography, Thin Layer; Cotinine; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Humans; Infusions, Intravenous; Linear Models; Male; Nicotine; Smoking; White People	1998
A solid phase extraction method for determination of nicotine in serum and urine by isotope dilution gas chromatography/mass spectrometry with selected ion monitoring. Annals of clinical biochemistry, 1998, Volume: 35 ( Pt 4) Topics: Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Indicator Dilution Techniques; Nicotine	1998
Influence of menstrual cycle on cytochrome P450 2A6 activity and cardiovascular effects of nicotine. Clinical pharmacology and therapeutics, 2005, Volume: 77, Issue:3 Topics: Adrenocorticotropic Hormone; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Cardiovascular Agents; Clinical Trials as Topic; Cotinine; Cytochrome P-450 CYP2A6; Deuterium; Epinephrine; Estradiol; Female; Follicular Phase; Heart Rate; Humans; Infusions, Intravenous; Luteal Phase; Mixed Function Oxygenases; Nicotine; Norepinephrine; Progesterone	2005
Investigation of the mechanism of nicotine demethylation in Nicotiana through 2H and 15N heavy isotope effects: implication of cytochrome P450 oxidase and hydroxyl ion transfer. Archives of biochemistry and biophysics, 2007, Feb-15, Volume: 458, Issue:2 Topics: Deuterium; Hydroxides; Methylation; Models, Chemical; NADPH-Ferrihemoprotein Reductase; Nicotiana; Nicotine; Nitrogen Isotopes; Pyrrolidines	2007
Analysis of [3',3'-d(2)]-nicotine and [3',3'-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Sep-15, Volume: 857, Issue:1 Topics: Administration, Oral; Biomarkers; Calibration; Capillary Electrochromatography; Chromatography, High Pressure Liquid; Cotinine; Deuterium; Humans; Injections, Intravenous; Molecular Structure; Nicotine; Radioactive Tracers; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Smoking; Smoking Cessation; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry	2007
Genome-wide linkage of cotinine pharmacokinetics suggests candidate regions on chromosomes 9 and 11. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009, Jun-05, Volume: 150B, Issue:4 Topics: Adolescent; Child; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 9; Cotinine; Deuterium; Female; Genome-Wide Association Study; Humans; Indicators and Reagents; Male; Nicotine	2009
Characterization of Canadian cigarettes using multi-stable isotope analysis by gas chromatography-isotope ratio mass spectrometry. Journal of agricultural and food chemistry, 2009, Feb-25, Volume: 57, Issue:4 Topics: Canada; China; Deuterium; Gas Chromatography-Mass Spectrometry; Hydrogen; Isotopes; Nicotiana; Nicotine; Nitrogen; Nitrogen Isotopes; Smoking	2009
Nicotine, acetanilide and urea multi-level 2H-, 13C- and 15N-abundance reference materials for continuous-flow isotope ratio mass spectrometry. Rapid communications in mass spectrometry : RCM, 2009, Volume: 23, Issue:22 Topics: Acetanilides; Calibration; Deuterium; Mass Spectrometry; Nicotine; Nitrogen Isotopes; Oxygen Isotopes; Reference Standards; Urea	2009
[Study of pharmacokinetics of nicotine in local brain by using microdialysis and stable labeled isotope]. Yao xue xue bao = Acta pharmaceutica Sinica, 2011, Volume: 46, Issue:3 Topics: Administration, Cutaneous; Administration, Intranasal; Animals; Area Under Curve; Brain; Chromatography, High Pressure Liquid; Deuterium; Female; Isotope Labeling; Male; Microdialysis; Nicotine; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2011
Determination of nicotine exposure in dogs subjected to passive smoking using methanol extraction of hair followed by hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry. Talanta, 2012, Jan-15, Volume: 88 Topics: Animals; Calibration; Chemical Fractionation; Chromatography, Liquid; Cotinine; Deuterium; Dogs; Hair; Hydrophobic and Hydrophilic Interactions; Methanol; Nicotine; Oxidation-Reduction; Sodium Hydroxide; Solvents; Sonication; Spectroscopy, Fourier Transform Infrared; Tobacco Smoke Pollution	2012
[Pharmacokinetics of nicotine in blood and brain using microdialysis and stable labelled isotope]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:1 Topics: Animals; Brain; Brain Chemistry; Deuterium; Isotope Labeling; Male; Microdialysis; Nicotine; Rats; Rats, Sprague-Dawley	2012
Low-energy electron-induced dissociation in gas-phase nicotine, pyridine, and methyl-pyrrolidine. The Journal of chemical physics, 2017, Sep-07, Volume: 147, Issue:9 Topics: Deuterium; Electrons; Gases; Models, Molecular; Nicotine; Pyridines; Pyrrolidines; Thermodynamics	2017