nicotine has been researched along with cytisine in 236 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (7.63) | 18.7374 |
| 1990's | 86 (36.44) | 18.2507 |
| 2000's | 73 (30.93) | 29.6817 |
| 2010's | 49 (20.76) | 24.3611 |
| 2020's | 10 (4.24) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Bottlaender, M; Coulon, C; Crouzel, C; Dolci, L; Doll, F; Fuseau, C; Guenther, I; Hinnen, F; Valette, H; Vaufrey, F | 1 |
| Efange, SM; Francesconi, L; Howell, RC; Kung, MP; Papke, RL; Rampersad, MV; Todaro, LJ; Tu, Z; von Hohenberg, K | 1 |
| Chen, S; Cheng, J; Izenwasser, S; Paul, D; Stevens, ED; Trudell, ML; Wade, D; Zhang, C | 1 |
| Baydyuk, M; Davis, HE; Kellar, KJ; Wang, HP; Xiao, Y | 1 |
| Arnold, EP; Brooks, PR; Chambers, LK; Coe, JW; Davis, TI; Fox, CB; Heym, JH; Huang, J; Lebel, LA; Lu, Y; Mansbach, RS; O'Neill, BT; Rollema, H; Rovetti, CC; Sands, SB; Schaeffer, E; Schulz, DW; Shrikhande, A; Tingley, FD; Vetelino, MG; Wirtz, MC | 1 |
| Arnold, EP; Bashore, CG; Brooks, PR; Coe, JW; Davis, TI; Fox, CB; Lebel, LA; O'Neill, BT; Rollema, H; Sands, SB; Schulz, DW; Tingley, FD; Vetelino, MG; Wirtz, MC | 1 |
| Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Liljefors, T | 1 |
| Arnold, EP; Bashore, CG; Bianco, KE; Brooks, PR; Coe, JW; Davis, TI; Fox, CB; Lebel, LA; Mansbach, RS; O'Neill, BT; Rollema, H; Sands, SB; Schulz, DW; Tingley, FD; Vetelino, MG; Wirtz, MC | 1 |
| Chellappan, SK; Kellar, KJ; Kozikowski, AP; Tueckmantel, W; Xiao, Y | 1 |
| Jiang, F; Olsen, C; Polgar, W; Toll, L; Zaveri, N | 1 |
| Benson, LR; Bhatti, BS; Breining, SR; Byrd, GD; Fedorov, NB; Hepler, CD; Hooker, DN; Kiser, MN; Lucero, LM; Lukas, RJ; Melvin, M; Mitchener, JP; Reynolds, LA; Sidach, SS; Whiteaker, P; Yohannes, D; Zhang, J | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Fasoli, F; Gotti, C; Novelli, F; Sparatore, F; Tasso, B | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Clifford, DB; Isenberg, KE; Thio, LL; Zorumski, CF | 1 |
| Ballivet, M; Bertrand, D; Bertrand, S | 1 |
| Cohen, BN; Davidson, N; Figl, A; Lester, HA; Quick, MW | 1 |
| Luetje, CW; Patrick, J | 1 |
| Flores, CM; Kellar, KJ; Pabreza, LA; Rogers, SW; Wolfe, BB | 1 |
| Fung, YK | 1 |
| Dhawan, S; Kellar, KJ; Pabreza, LA | 1 |
| Archer, T; Gillberg, PG; Gordh, T; Hartvig, P; Jansson, I; Post, C; Sottile, A | 1 |
| Reavill, C; Stolerman, IP | 1 |
| Collins, AC; Lippiello, PM; Marks, MJ; Romm, E | 1 |
| Reavill, C; Stolerman, IP; Testa, B; Walther, B | 1 |
| Barlow, RB; Johnson, O | 1 |
| Beyer, HS; Matta, SG; McAllen, KM; Sharp, BM | 1 |
| Fujiwara, M; Kameyama, M; Shimohama, S; Taniguchi, T | 1 |
| Craft, RM; Howard, JL | 1 |
| Bostwick, M; Hook, R; Martin, WR; Sloan, JW; Wala, E | 1 |
| Cairns, NJ; Wonnacott, S | 1 |
| Adem, A; Botros, M; Nordberg, A; Ohman, B; Synnergren, B; Winblad, B | 1 |
| Metelitsa, VI | 1 |
| Dixon, JS; Nilakantan, R; Sheridan, RP; Venkataraghavan, R | 1 |
| Hook, R; Kaplan, E; Martin, WR; Sloan, JW; Wash, C | 1 |
| Kellar, KJ; Schwartz, RD | 1 |
| Beani, L; Bianchi, C; Nilsson, L; Nordberg, A; Romanelli, L; Sivilotti, L | 1 |
| Garcha, HS; Giardini, V; Kumar, R; Pratt, JA; Stolerman, IP | 1 |
| Garcha, HS; Kumar, R; Pratt, JA; Stolerman, IP | 1 |
| Chuprin, VV; Komarov, VM; Marakulin, VS | 1 |
| Goldstein, A; Jewell, NP; Romano, C | 1 |
| Barrantes, GE; Murphy, CT; Westwick, J; Wonnacott, S | 1 |
| Adams, P; Anderson, DJ; Arneric, SP; Briggs, CA; Cadman, ED; Donnelly-Roberts, D; Garvey, DS; Hughes, ML; Raszkiewicz, JL; Sullivan, JP | 1 |
| Abraham, D; Oortgiesen, M; Vijverberg, HP; Zwart, R | 1 |
| Muramatsu, I; Takita, M | 1 |
| Berman, SA; Bursztajn, S; Didier, M; Lindstrom, J | 1 |
| Holstad, SG; Hong, SE; Isenberg, KE; Mennerick, SJ; Wong, ET; Zorumski, CF | 1 |
| Museo, E; Wise, RA | 1 |
| Gong, ZH; Hellström-Lindahl, E; Nordberg, A; Zhang, X | 1 |
| Foster, CA; Matta, SG; McCoy, JG; Sharp, BM | 1 |
| Bisset, GW; Fairhall, KM | 1 |
| Chan, J; Patrick, J; Quik, M | 1 |
| Auman, JT; Briggs, SJ; Christopher, NC; Levin, ED | 1 |
| Arneric, SP; Brioni, JD; Buckley, MJ; Carrera, GM; Decker, MW; Garvey, DS; Holladay, MW; Sullivan, JP; Wasicak, JT; Williams, M | 1 |
| Clementi, F; Court, JA; Morris, C; Perry, E; Rubboli, F; Sala, C | 1 |
| Khan, IM; Printz, MP; Taylor, P; Yaksh, TL | 1 |
| Adams, P; Anderson, DJ; Bannon, AW; Brioni, JD; Buckley, MJ; Decker, MW; Donnelly-Roberts, D; Kang, CH; Piattoni-Kaplan, M; Sullivan, JP | 1 |
| Khan, IM; Taylor, P; Yaksh, TL | 3 |
| Brioni, JD; Decker, MW; Kim, DJ; O'Neill, AB; Williams, JE | 1 |
| Bobbin, RP; Erostegui, C; Norris, CH | 1 |
| Hua, XY; Jinno, S; Yaksh, TL | 1 |
| Biftu, T; Eckman, J; Ip, S; Li, T; Libertine-Garahan, L; Qian, C; Shen, TY | 1 |
| Flesher, JE; Frost, JJ; London, ED; Scheffel, U | 1 |
| Anderson, DJ; Arneric, SP | 1 |
| Arneric, SP; Linville, DG; Raszkiewicz, JL; Williams, S | 1 |
| Amar, M; Johnson, C; Lunt, GG; Thomas, P; Wonnacott, S | 1 |
| Brioni, JD; Decker, MW; Kim, DJ; O'Neill, AB | 1 |
| Chad, JE; Foreman, R; Wheeler, SV | 1 |
| Cimino, M; Clementi, F; Fraschini, F; Lucini, V; Marini, P; Stankov, B | 1 |
| Arneric, SP; Brioni, JD | 1 |
| Anderson, DJ; Arneric, SP; Donnelly-Roberts, D; Gopalakrishnan, M; Molinari, EJ; Monteggia, LM; Piattoni-Kaplan, M; Sullivan, JP | 1 |
| Iida, Y; Kiyono, Y; Magata, Y; Saji, H; Takaishi, Y; Watanabe, A; Yokoyama, A | 1 |
| Clarke, PB; Reuben, M | 1 |
| Quirion, R; Rochford, J; Sen, AP | 1 |
| Nordberg, A; Warpman, U | 1 |
| Frazier, CJ; Hall, ME; Rollins, YD; Rose, GM; Young, DA | 1 |
| Konishi, Y; Muramatsu, I; Sudo, M; Takita, M; Zhu, J | 1 |
| Nordberg, A; Svensson, AL | 1 |
| Bordey, A; Feltz, P; Trouslard, J | 1 |
| Changeux, JP; Léna, C | 2 |
| Liang, SD; Vizi, ES | 1 |
| Baranyi, M; Lajtha, A; Lendvai, B; Santha, E; Sershen, H; Vizi, ES | 1 |
| Imoto, M; Ohno, T; Saito, K; Tani, Y; Tsuneyoshi, A | 1 |
| Chandler, CJ; Stolerman, IP | 1 |
| Colquhoun, D; Lewis, TM; McNeil, DK; Nassar, MA; Schoepfer, R; Sivilotti, LG | 1 |
| Gopalakrishnan, M; Molinari, EJ; Sullivan, JP | 1 |
| Demirgören, S; Koylu, E; London, ED; Pöğün, S | 1 |
| Dávila-García, MI; Flores, CM; Kellar, KJ; Ulrich, YM | 1 |
| Goldberg, SR; Pauly, JR; Schindler, CW; Shoaib, M | 1 |
| Gallardo, KA; Leslie, FM | 1 |
| Akaike, A; Kihara, T; Kimura, J; Kume, T; Maeda, T; Sawada, H; Shimohama, S; Urushitani, M | 1 |
| Dannals, RF; Finley, PA; Mochizuki, T; Musachio, JL; Scheffel, U; Wagner, HN; Zhan, Y | 1 |
| de la Lande, IS; Marino, V; Parker, DA; Zisimopoulos, S | 1 |
| Gillberg, PG; Nordberg, A; Sihver, W | 1 |
| Imoto, M; Ohno, T; Saito, K; Tani, Y | 1 |
| Gorbounova, O; Hellström-Lindahl, E; Mousavi, M; Nordberg, A; Seiger, A | 1 |
| Beck, A; Luetje, CW; Parker, MJ | 1 |
| Paradiso, K; Sabey, K; Steinbach, JH; Zhang, J | 1 |
| Buerkle, H; Khan, IM; Taylor, P; Yaksh, TL | 1 |
| Bottlaender, M; Coulon, C; Crouzel, C; Dollé, F; Fuseau, C; Guenther, I; Hinnen, F; Ottaviani, M; Valette, H | 1 |
| Dávila-García, MI; Houghtling, RA; Kellar, KJ; Qasba, SS | 1 |
| Clark, E; Janowsky, DS; Kling, MA; Louis, VA; Overstreet, DH; Rezvani, AH; Tizabi, Y | 1 |
| Fryer, J; Herl, J; Leonard, SS; Lucero, L; Lukas, RJ; Peng, JH | 1 |
| Akaike, A; Kihara, T; Shimohama, S | 1 |
| Lima, R; Titmus, MJ; Tsai, HJ; Udin, SB | 1 |
| Muramatsu, I; Piao, HL; Takita, M; Taniguchi, T; Tsai, TY; Zhu, J | 1 |
| Brus, R; Copeland, RL; Kostrzewa, RM; Tizabi, Y | 1 |
| Anderson, KG; Haworth, SC; Kem, WR; van Haaren, F | 1 |
| Allen, D; Benuck, M; Cooper, TB; Hashim, A; Lajtha, A; Lipovac, M; Sershen, H; Sziráki, I | 1 |
| Gillberg, PG; Nordberg, A; Sihver, W; Svensson, AL | 1 |
| McCook, EC; Seidler, FJ; Slotkin, TA; Trauth, JA | 1 |
| Overstreet, DH; Rezvani1, AH; Russell, LT; Tizabi, Y; Tyler, KY | 1 |
| Davis, CB; Lee, DH; Shank, RP; Wang, HY | 1 |
| Collins, AC; Jimenez, M; Lu, Y; Stitzel, JA; Tritto, T | 1 |
| Galligan, JJ; Schneider, DA | 1 |
| Berkovic, SF; Clifford, JJ; Drago, J; Horne, MK; Kinsella, A; Kola, I; Massalas, JS; Ross, SA; Scheffer, IE; Waddington, JL; Wong, JY | 1 |
| Collins, AC; Jimenez, M; Marks, MJ; McIntosh, JM; Whiteaker, P | 1 |
| Faltynek, CR; Jacobs, I; Puttfarcken, PS | 1 |
| Hauser, KF; Opanashuk, LA; Pauly, JR | 1 |
| Cormier, A; Lagrue, G; Morin, C; Tillement, JP; Zini, R | 1 |
| Ridley, DL; Rogers, A; Wonnacott, S | 1 |
| Hellström-Lindahl, E; Kjaeldgaard, A; Nordberg, A | 1 |
| Lukas, RJ; Pacheco, MA; Pastoor, TE; Wecker, L | 1 |
| Genzen, JR; McGehee, DS; Van Cleve, W | 1 |
| Choi, CH; Gerzanich, V; Kuryatov, A; Lindstrom, J; Nelson, ME; Wang, F | 1 |
| Abdrakhmanova, G; Dorfman, J; Morad, M; Xiao, Y | 1 |
| Bessis, A; Champtiaux, N; Changeux, JP; Han, ZY; Marubio, L; McIntosh, JM; Rossi, FM; Zoli, M | 1 |
| Albuquerque, EX; Alkondon, M | 1 |
| Kuryatov, A; Lindstrom, J; Nelson, ME; Rush, R | 1 |
| Bottlaender, M; Coulon, C; Dannals, RF; Dolle, F; Kassiou, M; Loc'h, C; Maziere, B; Musachio, JL; Ottaviani, M | 1 |
| Chapman, J; Korczyn, AD; Nachman, R; Orr-Urtreger, A; Rabinowitz, R; Wang, N | 1 |
| Anderson, DJ; Jacobs, I; Puttfarcken, PS; Surowy, CS | 1 |
| Steinbach, JH; Zhang, J | 1 |
| Boules, M; Fredrickson, P; Richelson, E; Yerbury, S | 1 |
| Gu, JG; Nakatsuka, T; Papke, R; Takeda, D | 1 |
| Lee, DH; Wang, HY | 1 |
| Bourgeois, JP; Cardona, A; Changeux, JP; Han, ZY; Le Novère, N; Zoli, M | 1 |
| KNAUFF, HG; SCHMID, E | 1 |
| Adams, P; Correa, LD; Rao, TS; Sacaan, AI; Santori, EM | 1 |
| Dussor, GO; Flores, CM; Gracia, NB; Hargreaves, KM; Kilo, S; Leong, AS; Price, TJ | 1 |
| Abreu-Villaça, Y; Cousins, MM; Seidler, FJ; Slotkin, TA; Tate, CA | 1 |
| Abdel-Rahman, A; Abou-Donia, MB; Dechkovskaia, AM; Guan, X; Khan, WA; Mehta-Simmons, H; Sutton, JM | 1 |
| Botuha, C; Gallagher, T; Galley, CM | 1 |
| Bordia, T; Clementi, F; Fan, H; Gotti, C; Kulak, JM; McIntosh, JM; Quik, M; Vailati, S | 1 |
| Collins, AC; Deshpande, P; Labarca, C; Lester, HA; Marks, MJ; McKinney, SL; Nashmi, R; Schwarz, J; Tapper, AR; Whiteaker, P | 1 |
| Jenkins, PM; Karadsheh, MS; Li, XC; Stitzel, JA | 1 |
| Jozwiak, K; Moaddel, R; Wainer, IW; Whittington, K | 1 |
| Grill, V; Hellström-Lindahl, E; Yoshikawa, H | 1 |
| Bermudez, I; Groot-Kormelink, PJ; Smulders, CJ; van Kleef, RG; Vijverberg, HP; Zwart, R | 1 |
| Falk, L; Hellström-Lindahl, E; Kjaeldgaard, A; Nordberg, A; Seiger, A | 1 |
| Collins, AC; Grady, SR; Marks, MJ; McIntosh, JM; Salminen, O; Whiteaker, P | 1 |
| Gao, J; Hui, X; Ogiku, T; Suto, N; Wang, MW; Xie, X | 1 |
| Ikeuchi, T; Isosaki, M; Nakayama, H; Satoh, H; Shimoke, K; Yoshizumi, M | 1 |
| Canu-Boido, C; Clementi, F; Di Angelantonio, S; Gaimarri, A; Gotti, C; Matteoni, C; Nistri, A; Riganti, L; Sparatore, F | 1 |
| Badyuk, M; Daly, JW; Kellar, KJ; Ohtani, M; Oka, T; Xiao, Y | 1 |
| Abin-Carriquiry, JA; Bermúdez, I; Cassels, BK; Dajas, F; Wonnacott, S | 1 |
| Bubl, B; Feuerstein, TJ; Hubbe, U; Huethe, F; Jackisch, R; Löffler, M; McIntosh, JM | 1 |
| Abin-Carriquiry, JA; Barik, J; Bermudez, I; Cassels, BK; Dajas, F; Durand, C; Iturriaga-Vásquez, P; Voutilainen, MH; Wonnacott, S | 1 |
| Bouairi, E; Dergacheva, O; Gorini, C; Huang, ZG; Kamendi, H; McIntosh, JM; Mendelowitz, D; Stephens, C; Wang, X | 1 |
| Bermudez, I; Cassels, BK; Moroni, M; Sher, E; Zwart, R | 1 |
| Azam, L; McIntosh, JM | 1 |
| Hu, J; Kuo, YP; Liu, Q; Lukas, RJ; Segerberg, M; St John, PA; Wu, J; Yu, K | 1 |
| Cedzynska, M; Tutka, P; West, R; Zatonski, W | 1 |
| Cahill, K; Lancaster, T; Stead, LF | 5 |
| Collins, AC; Damaj, MI; Deshpande, P; Fonck, C; Labarca, C; Lester, HA; Marks, MJ; Martin, BR | 1 |
| Changeux, JP; Huck, S; McIntosh, JM; Orr-Urtreger, A; Scholze, P | 1 |
| Benowitz, NL; Dresler, CM; Etter, JF; Lukas, RJ; West, R | 1 |
| Cahill, K; Lancaster, T; Stead, L | 1 |
| Caldwell, DP; Getachew, B; Hauser, SR; Hunter, C; Levin, ED; Rezvani, AH; Tizabi, Y | 1 |
| Abin-Carriquiry, JA; Cassels, BK; Costa, G; Dajas, F; Rebolledo-Fuentes, M; Urbanavicius, J; Wonnacott, S | 1 |
| Carroll, FI; Corrigall, WA; LeSage, MG; Ross, JT; Shelley, D | 1 |
| Getachew, B; Hauser, SR; Overstreet, DH; Rezvani, AH; Tizabi, Y | 1 |
| Hu, J; Jin, G; Liu, Q; Lucero, L; Lukas, RJ; Wu, J; Yang, K; Zhen, X; Zheng, C | 1 |
| Einarson, A; Riordan, S | 1 |
| Bernal, JA; Castillo, M; Criado, M; Mulet, J; Sala, F; Sala, S | 1 |
| Abutaha, A; Hosur, V; Leppanen, S; Loring, RH | 1 |
| Abin-Carriquiry, JA; Cassels, BK; Dajas, F; Wonnacott, S; Zunini, MP | 1 |
| Papke, RL | 1 |
| Li, P; Steinbach, JH | 1 |
| Cunningham, CS; McMahon, LR | 2 |
| Al Rubaiy, SA; Bloom, SA; Guendisch, D; Papke, RL; Trocmé-Thibierge, C | 1 |
| Hosokawa, R; Iida, T; Inagaki, T; Inenaga, K; Ono, K | 1 |
| Kobus, A | 1 |
| Arias, HR; Feuerbach, D; Jozwiak, K; Targowska-Duda, KM | 1 |
| Abizaid, A; De Biasi, M; Diano, S; DiLeone, RJ; Gao, XB; Gündisch, D; Horvath, TL; Mineur, YS; Picciotto, MR; Rao, Y; Salas, R | 1 |
| Barnes, J; Bullen, C; Glover, M; Howe, C; McRobbie, H; Nosa, V; Parag, V; Veale, R; Walker, N; Williman, J | 1 |
| Stapleton, JA; West, R | 1 |
| Cunningham, CS; Javors, MA; McMahon, LR | 1 |
| Eibl, C; Guendisch, D; Kirtok, N; LaGamma, EF; Nankova, BB; Turcanu, DS | 1 |
| Gallagher, T; Haseler, CA; Rucktooa, P; Sixma, TK; Smit, AB; van Elk, R | 1 |
| Papke, RL; Stokes, C | 1 |
| Carpenter, LL; Philip, NS; Price, LH; Tyrka, AR | 1 |
| Dougherty, DA; Korlach, J; Lester, HA; Luong, K; Richards, CI; Srinivasan, R; Turner, SW | 1 |
| Rahman, S; Sajja, RK | 1 |
| Braida, D; Clementi, F; Fasoli, F; Fucile, S; Gotti, C; Grady, SR; Loi, B; Manfredi, I; Marks, MJ; Pucci, L; Sala, M; Sparatore, F; Tasso, B; Wageman, CR; Zoli, M | 1 |
| Hajek, P; McRobbie, H; Myers, K | 1 |
| Kubicki, M; Niedźwiecka, J; Przybył, AK | 1 |
| Milnerowicz, H; Sliwińska-Mossoń, M; Zieleń, I | 1 |
| Alexander, JC; Bruijnzeel, AW; Igari, M; Ji, Y; Papke, RL; Qi, X | 1 |
| Benowitz, NL; Das, S; Prochaska, JJ | 1 |
| Braida, D; Gotti, C; Martucci, R; Ponzoni, L; Sala, M; Sparatore, F | 1 |
| Cieślewicz, A; Jabłecka, A; Korzeniowska, K | 1 |
| Grady, SR; Marks, MJ; McIntosh, JM; Paley, MA; Salminen, O; Wageman, CR; Whiteaker, P | 1 |
| Kuryatov, A; Ley, CK; Lindstrom, JM; Wang, J | 1 |
| Barnes, J; Bassett, B; Bullen, C; Glover, M; Howe, C; McRobbie, H; Nosa, V; Parag, V; Walker, N | 1 |
| Rigotti, NA | 1 |
| Loetz, EC; Marks, MJ; Meyers, EE | 1 |
| Bespalov, AY; Dravolina, OA; Radchenko, EV | 1 |
| Benowitz, NL; Prochaska, JJ | 1 |
| Grudzień, M; Mazurek, AP; Pieńko, T; Taciak, PP | 1 |
| Cahill, K; Fanshawe, TR; Lancaster, T; Lindson-Hawley, N; Thomas, KH | 1 |
| Abreu-Villaça, Y; Correa-Santos, M; Dutra-Tavares, AC; Filgueiras, CC; Manhães, AC; Nunes-Freitas, A; Paes-Branco, D; Ribeiro-Carvalho, A | 1 |
| Barnes, J; Bullen, C; Castaldelli-Maia, JM; Courtney, RJ; Etter, JF; McRobbie, H; Raw, M; Rigotti, NA; Selby, P; Sheridan, J; Siddiqi, K; Tutka, P; Walker, N | 1 |
| de Moura, FB; McMahon, LR | 2 |
| Karnieg, T; Wang, X | 1 |
| Absalom, NL; Ahring, PK; Balle, T; Chebib, M; Indurthi, DC; Lewis, TM; Liao, VW; Qudah, T | 1 |
| Baker, DL; Deats, S; DeMichele, G; Dymond, R; O'Brien, M; Pagán, OR | 1 |
| Apolone, G; Boeri, M; Boffi, R; Gallus, S; Ladisa, V; Ledda, RE; Marchianò, A; Milanese, G; Munarini, E; Pastorino, U; Rolli, L; Sabia, F; Sozzi, G; Suatoni, P; Trussardo, S; Valsecchi, C | 1 |
| Bendiks, S; Blokhina, E; Bryant, K; Cheng, DM; Freiberg, MS; Gnatienko, N; Hahn, J; Krupitsky, E; Lioznov, D; Patts, G; Samet, JH; So-Armah, K; Stein, MD; Tindle, HA; Yaroslavtseva, T | 1 |
| Ashburner, JM; Klemenc Ketiš, Z; Oreskovic, S; Oreskovic, T; Percac-Lima, S; Rifel, J; Tiljak, H | 1 |
| Benowitz, NL; Blumenstein, B; Cain, D; Clarke, A; Jacobs, C; Leischow, S; Nides, M; Prochaska, J; Rigotti, NA | 1 |
| Berríos-Cárcamo, P; Cassels, BK; Quintanilla, ME; Rivera-Meza, M | 1 |
| Budzyńska, B; Chałas, R; Maciąg, M; Rahnama-Hezavah, M; Stachurski, P; Świątkowska, A; Świątkowski, W; Tylżanowski, P | 1 |
| Dennis, BB; Devereaux, PJ; Fairbairn, N; Lu, C; Mbuagbaw, L; Ofori, S; Olasupo, OO | 1 |
| Barnes, J; Bullen, C; Calder, A; Laking, G; Parag, V; Walker, N | 1 |
19 review(s) available for nicotine and cytisine
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic | 2005 |
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Drug Design; Humans; Ligands; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Structure-Activity Relationship | 2005 |
Nicotine receptor partial agonists for smoking cessation.
Topics: Alkaloids; Azocines; Benzazepines; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Randomized Controlled Trials as Topic; Smoking Cessation; Varenicline | 2007 |
Cytisine for smoking cessation: a research agenda.
Topics: Alkaloids; Animals; Azocines; Clinical Trials as Topic; Drug Overdose; Humans; Nicotine; Quinolizines; Smoking Cessation; Substance-Related Disorders | 2008 |
An update on therapeutics for tobacco dependence.
Topics: Alkaloids; Anti-Anxiety Agents; Azocines; Benzazepines; Bupropion; Clinical Trials as Topic; Databases, Bibliographic; Humans; Nicotine; Nicotinic Agonists; Piperidines; Pyrazoles; Quinolizines; Quinoxalines; Review Literature as Topic; Rimonabant; Smoking; Smoking Cessation; Varenicline | 2008 |
Nicotine receptor partial agonists for smoking cessation.
Topics: Alkaloids; Azocines; Benzazepines; Bupropion; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Randomized Controlled Trials as Topic; Smoking; Smoking Cessation; Varenicline | 2008 |
Smoking in pregnancy and lactation: a review of risks and cessation strategies.
Topics: Adult; Alkaloids; Antidepressive Agents; Azocines; Benzazepines; Breast Feeding; Bromocriptine; Cognitive Behavioral Therapy; Female; Humans; Lactation; Nicotine; Nicotinic Agonists; Pregnancy; Pregnancy Complications; Quinolizines; Quinoxalines; Risk Assessment; Risk Factors; Smoking; Smoking Cessation; Vaccines; Varenicline; Young Adult | 2009 |
Nicotine receptor partial agonists for smoking cessation.
Topics: Alkaloids; Azocines; Benzazepines; Bupropion; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Randomized Controlled Trials as Topic; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Varenicline | 2010 |
Nicotine receptor partial agonists for smoking cessation.
Topics: Alkaloids; Azocines; Benzazepines; Bupropion; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Randomized Controlled Trials as Topic; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Varenicline | 2011 |
[Simple therapeutic options in counteracting tobacco smoking].
Topics: Alkaloids; Azocines; Humans; Nicotine; Quinolizines; Smoking; Smoking Cessation; Tobacco Use Disorder | 2010 |
Nicotine receptor partial agonists for smoking cessation.
Topics: Alkaloids; Azepines; Azocines; Benzazepines; Bupropion; Counseling; Heterocyclic Compounds, 4 or More Rings; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Randomized Controlled Trials as Topic; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Varenicline | 2012 |
The nicotinic acetylcholine receptor as a target for antidepressant drug development.
Topics: Alkaloids; Antidepressive Agents; Azocines; Humans; Mecamylamine; Nicotine; Nicotinic Agonists; Quinolizines; Receptors, Nicotinic | 2012 |
Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis.
Topics: Alkaloids; Azocines; Humans; Nicotine; Public Health; Quinolizines; Smoking; Smoking Cessation; Smoking Prevention; Treatment Outcome | 2013 |
[Drugs used to treat nicotine addiction].
Topics: Adult; Age Distribution; Alkaloids; Azocines; Benzazepines; Bupropion; Causality; Comorbidity; Female; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Poland; Quinolizines; Quinoxalines; Sex Distribution; Smoking; Smoking Cessation; Smoking Prevention; Tobacco Use Disorder; Varenicline; Young Adult | 2012 |
The Past, Present, and Future of Nicotine Addiction Therapy.
Topics: Alkaloids; Azocines; Bupropion; Directive Counseling; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Health Policy; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Smoking Cessation; Social Media; Text Messaging; Tobacco Use Cessation Devices; Tobacco Use Disorder; Varenicline | 2016 |
Nicotine receptor partial agonists for smoking cessation.
Topics: Alkaloids; Azepines; Azocines; Benzazepines; Bupropion; Counseling; Heterocyclic Compounds, 4 or More Rings; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Randomized Controlled Trials as Topic; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Varenicline | 2016 |
Cytisine for smoking cessation: A systematic review and meta-analysis.
Topics: Adult; Alkaloids; Azocines; Benzazepines; Bupropion; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Smoking Cessation; Varenicline | 2023 |
8 trial(s) available for nicotine and cytisine
| Article | Year |
|---|---|
An uncontrolled trial of cytisine (Tabex) for smoking cessation.
Topics: Adult; Alkaloids; Azocines; Female; Humans; Male; Nicotine; Poland; Quinolizines; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Treatment Outcome | 2006 |
Study protocol for a non-inferiority trial of cytisine versus nicotine replacement therapy in people motivated to stop smoking.
Topics: Adult; Alkaloids; Azocines; Clinical Protocols; Humans; Motivation; New Zealand; Nicotine; Quinolizines; Sample Size; Single-Blind Method; Smoking; Smoking Cessation; Smoking Prevention; Tobacco Use Cessation Devices; Treatment Outcome | 2011 |
Cytisine versus nicotine for smoking cessation.
Topics: Adult; Alkaloids; Azocines; Female; Humans; Male; Middle Aged; Nausea; Nicotine; Quinolizines; Smoking Cessation; Tobacco Use Cessation Devices; Tobacco Use Disorder; Treatment Outcome | 2014 |
Cytisine Therapy Improved Smoking Cessation in the Randomized Screening and Multiple Intervention on Lung Epidemics Lung Cancer Screening Trial.
Topics: Alkaloids; Azocines; Early Detection of Cancer; Humans; Lung; Lung Neoplasms; Nicotine; Quinolizines; Smoking Cessation; Varenicline | 2022 |
Effectiveness of Varenicline and Cytisine for Alcohol Use Reduction Among People With HIV and Substance Use: A Randomized Clinical Trial.
Topics: Adult; Alcoholism; Alkaloids; Azocines; Benzazepines; Female; HIV Infections; Humans; Male; Nicotine; Nicotinic Agonists; Quinolizines; Smoking Cessation; Tobacco Use Cessation Devices; Varenicline | 2022 |
Cytisine Versus Varenicline for Smoking Cessation in a Primary Care Setting: A Randomized Non-inferiority Trial.
Topics: Alkaloids; Azocines; Benzazepines; Humans; Nicotine; Nicotinic Agonists; Primary Health Care; Quinolizines; Smoking Cessation; Treatment Outcome; Varenicline | 2023 |
Cytisinicline for Smoking Cessation: A Randomized Clinical Trial.
Topics: Alkaloids; Azocines; Cigarette Smoking; Double-Blind Method; Duration of Therapy; Female; Humans; Male; Middle Aged; Nicotine; Quinolizidine Alkaloids; Quinolizines; Receptors, Nicotinic; Smoking Cessation; Smoking Cessation Agents; Tobacco Use Disorder; Treatment Outcome | 2023 |
Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based randomised controlled trial.
Topics: Electronic Nicotine Delivery Systems; Humans; New Zealand; Nicotine; Quality of Life; Randomized Controlled Trials as Topic; Smoking Cessation; Sodium Chloride, Dietary; Tobacco Use Cessation Devices; Vaping; Varenicline | 2023 |
209 other study(ies) available for nicotine and cytisine
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.
Topics: Animals; Azetidines; Brain; Fluorine Radioisotopes; Humans; Ligands; Male; Papio; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tissue Distribution; Tomography, Emission-Computed | 1999 |
2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.
Topics: Acetylcholine; Animals; Cerebral Cortex; Chromans; Cloning, Molecular; Corpus Striatum; Crystallography, X-Ray; Dopamine; Humans; In Vitro Techniques; Nicotine; Nicotinic Agonists; Oocytes; Piperidines; Pyrrolidines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Synaptosomes; Xenopus laevis | 2001 |
Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes.
Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Dopamine; In Vitro Techniques; Injections, Spinal; Ligands; Mice; Nicotinic Agonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship | 2002 |
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Gene Expression; Humans; Neurons; Nicotinic Agonists; Protein Subunits; Rats; Receptors, Nicotinic; Transfection | 2004 |
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.
Topics: Animals; Benzazepines; Cell Line; Cerebral Cortex; Humans; In Vitro Techniques; Nicotinic Agonists; Oocytes; Quinoxalines; Radioligand Assay; Rats; Receptors, Nicotinic; Smoking Cessation; Varenicline; Xenopus laevis | 2005 |
In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.
Topics: Alkaloids; Animals; Azocines; Carbon; Dopamine; Nicotinic Agonists; Nucleus Accumbens; Quinolizines; Rats; Receptors, Nicotinic; Smoking Cessation; Structure-Activity Relationship | 2005 |
3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.
Topics: Animals; Cyclization; Molecular Structure; Piperidines; Rats; Receptors, Nicotinic; Smoking Cessation; Structure-Activity Relationship | 2005 |
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.
Topics: Alkaloids; Azocines; Cholinergic Agonists; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Structure; Nicotine; Quinolizines; Receptors, Cholinergic | 2006 |
Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Humans; Indoles; Ligands; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Transfection | 2010 |
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Electrophysiology; Humans; Kidney; Ligands; Molecular Structure; Neuroblastoma; Nicotine; Protein Subunits; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
(+)-Laburnamine, a natural selective ligand and partial agonist for the α4β2 nicotinic receptor subtype.
Topics: Alkaloids; Animals; Binding, Competitive; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Humans; Italy; Ligands; Neostriatum; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Seeds; Stereoisomerism | 2013 |
Nicotinic acetylcholine currents in cultured postnatal rat hippocampal neurons.
Topics: Acetylcholine; Alkaloids; Animals; Animals, Newborn; Azocines; Bungarotoxins; Cells, Cultured; Dimethylphenylpiperazinium Iodide; Evoked Potentials; Hippocampus; Ion Channels; Neurons; Nicotine; Quinolizines; Rats; Receptors, Nicotinic | 1992 |
Pharmacological properties of the homomeric alpha 7 receptor.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Hexamethonium Compounds; Nicotine; Oocytes; Quinolizines; Receptors, Cholinergic; Receptors, Nicotinic; Tubocurarine; Xenopus | 1992 |
Regions of beta 4.beta 2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors.
Topics: Acetylcholine; Alkaloids; Amino Acid Sequence; Animals; Azocines; DNA Mutational Analysis; Molecular Sequence Data; Neurons; Nicotine; Oocytes; Quaternary Ammonium Compounds; Quinolizines; Receptors, Nicotinic; Recombinant Fusion Proteins; Structure-Activity Relationship; Xenopus | 1992 |
Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Dimethylphenylpiperazinium Iodide; Female; In Vitro Techniques; Kinetics; Macromolecular Substances; Membrane Potentials; Microinjections; Neurons; Nicotine; Oocytes; Quinolizines; Receptors, Nicotinic; RNA; Transcription, Genetic; Xenopus laevis | 1991 |
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.
Topics: Alkaloids; Animals; Antibodies; Azocines; Brain; Kinetics; Macromolecular Substances; Male; Nicotine; Precipitin Tests; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Time Factors; Tritium; Up-Regulation | 1992 |
The importance of nucleus accumbens in nicotine-induced locomotor activity.
Topics: Alkaloids; Animals; Azocines; Male; Mecamylamine; Motor Activity; Nicotine; Nucleus Accumbens; Premedication; Quinolizines; Rats; Rats, Inbred Strains | 1990 |
[3H]cytisine binding to nicotinic cholinergic receptors in brain.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Binding, Competitive; Carbachol; Cerebral Cortex; Nicotine; Quinolizines; Rats; Receptors, Nicotinic; Tritium | 1991 |
Behavioral effects after intrathecal administration of cholinergic receptor agonists in the rat.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mecamylamine; Motor Activity; Nicotine; Nociceptors; Parasympathomimetics; Physostigmine; Quinolizines; Rats; Rats, Inbred Strains; Reaction Time; Tacrine | 1990 |
Locomotor activity in rats after administration of nicotinic agonists intracerebrally.
Topics: Alkaloids; Animals; Azocines; Brain; Corpus Striatum; Ganglionic Stimulants; Injections; Injections, Intraventricular; Male; Mecamylamine; Motor Activity; Nicotine; Nucleus Accumbens; Quinolizines; Rats; Thalamus | 1990 |
Purification of L-[3H]nicotine eliminates low affinity binding.
Topics: Alkaloids; Animals; Autoradiography; Azocines; Binding Sites; Binding, Competitive; Brain; Carbachol; Chromatography, Thin Layer; Ligands; Lobeline; Male; Mice; Mice, Inbred C57BL; Nicotine; Quinolizines | 1990 |
Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Lobeline; Male; Nicotine; Quinolizines; Rats | 1990 |
Relations between structure and nicotine-like activity: X-ray crystal structure analysis of (-)-cytisine and (-)-lobeline hydrochloride and a comparison with (-)-nicotine and other nicotine-like compounds.
Topics: Alkaloids; Azocines; Crystallization; Lobeline; Molecular Conformation; Nicotine; Quinolizines; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction | 1989 |
Nicotine elevates rat plasma ACTH by a central mechanism.
Topics: Adrenocorticotropic Hormone; Alkaloids; Animals; Azocines; beta-Endorphin; Cerebral Ventricles; Corticotropin-Releasing Hormone; Female; Hypothalamus; In Vitro Techniques; Injections, Intraventricular; Kinetics; Male; Nicotine; Pituitary Gland, Anterior; Quinolizines; Rats | 1987 |
Biochemical characterization of the nicotinic cholinergic receptors in human brain: binding of (-)-[3H]nicotine.
Topics: Acetylcholine; Aged; Alkaloids; Atropine; Azocines; Brain; Bungarotoxins; Carbachol; Cell Membrane; Female; Hexamethonium; Hexamethonium Compounds; Humans; Male; Nicotine; Quinolizines; Receptors, Cholinergic; Stereoisomerism; Thalamus; Tubocurarine | 1985 |
Cue properties of oral and transdermal nicotine in the rat.
Topics: Administration, Cutaneous; Administration, Oral; Alkaloids; Animals; Azocines; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Female; Mecamylamine; Nicotine; Ovariectomy; Quinolizines; Rats; Reinforcement Schedule; Time Factors | 1988 |
The comparative binding characteristics of nicotinic ligands and their pharmacology.
Topics: Alkaloids; Anabasine; Animals; Azocines; Brain; Dose-Response Relationship, Drug; Female; Hemodynamics; In Vitro Techniques; Ligands; Lobeline; Nicotine; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Respiration; Stereoisomerism | 1988 |
[3H](-)nicotine binding sites in fetal human brain.
Topics: Alkaloids; Azocines; Binding, Competitive; Brain; Embryonic and Fetal Development; Gestational Age; Humans; Nicotine; Quinolizines; Receptors, Nicotinic | 1988 |
[3H]acetylcholine nicotinic recognition sites in human brain: characterization of agonist binding.
Topics: Acetylcholine; Aged; Alkaloids; Animals; Azocines; Binding Sites; Brain; Carbachol; Humans; Male; Middle Aged; Nicotine; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Thalamus | 1987 |
[Pharmacological agents in controlling smoking].
Topics: Alkaloids; Anabasine; Azocines; Chewing Gum; Drug Evaluation; Female; Humans; Male; Mouthwashes; Nicotiana; Nicotine; Plants, Toxic; Quinolizines; Smoking Prevention; Substance Withdrawal Syndrome; Tobacco Use Disorder | 1987 |
The ensemble approach to distance geometry: application to the nicotinic pharmacophore.
Topics: Alkaloids; Azocines; Models, Structural; Molecular Conformation; Nicotine; Parasympathomimetics; Quinolizines; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Sympatholytics | 1986 |
Fourth ventricle effects of nicotine, 2-methylpiperidine and cytisine in dogs.
Topics: Alkaloids; Animals; Azocines; Blood Pressure; Body Temperature; Decerebrate State; Dogs; Electroencephalography; Heart Rate; Injections, Intraventricular; Nicotine; Pain Measurement; Piperidines; Pupil; Quinolizines; Receptors, Nicotinic; Stereoisomerism | 1986 |
In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Brain; Cerebral Cortex; Corpus Striatum; Cotinine; Dihydro-beta-Erythroidine; Ganglionic Stimulants; Hypothalamus; Isoflurophate; Male; Mecamylamine; Nicotine; Quinolizines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Thalamus | 1985 |
The effect of nicotine and cytisine on 3H-acetylcholine release from cortical slices of guinea-pig brain.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Cerebral Cortex; Electric Stimulation; Female; Ganglionic Stimulants; Guinea Pigs; In Vitro Techniques; Male; Nerve Endings; Nicotine; Quinolizines; Time Factors | 1985 |
Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms.
Topics: Alkaloids; Animals; Azocines; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Hexamethonium; Hexamethonium Compounds; Injections, Intraventricular; Male; Mecamylamine; Metergoline; Nicotine; Parasympatholytics; Quinolizines; Rats; Serotonin Antagonists | 1983 |
Role of training dose in discrimination of nicotine and related compounds by rats.
Topics: Alkaloids; Anabasine; Animals; Apomorphine; Azocines; Chlordiazepoxide; Cocaine; Discrimination, Psychological; Ganglionic Stimulants; Hexamethonium Compounds; Male; Mecamylamine; Nicotine; Oxotremorine; Picrotoxin; Quinolizines; Quipazine; Rats | 1984 |
[Treatment of nicotinism].
Topics: Acupuncture Therapy; Adolescent; Adult; Alkaloids; Autogenic Training; Azocines; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nicotine; Quinolizines; Smoking Prevention; Substance-Related Disorders | 1984 |
Characterization of the receptor mediating the nicotine discriminative stimulus.
Topics: Alkaloids; Animals; Azocines; Brain Chemistry; Cues; Discrimination Learning; Injections, Intraventricular; Male; Nicotine; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Nicotinic | 1981 |
Nicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels.
Topics: Aconitine; Alkaloids; Animals; Azocines; Calcium; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Fura-2; Hippocampus; Membrane Potentials; Nicotine; Quinolizines; Rats; Rats, Inbred Strains; Time Factors | 1995 |
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Cognition; Corpus Striatum; Dopamine; Ion Channels; Isoxazoles; Kinetics; Male; Mice; Nicotine; Parasympathomimetics; PC12 Cells; Pyrrolidines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Nicotinic; Rubidium; Rubidium Radioisotopes; Tritium | 1994 |
alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Alkaloids; Animals; Azocines; Bucladesine; Bungarotoxins; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Kinetics; Macromolecular Substances; Membrane Potentials; Mice; Neuroblastoma; Neurons; Nicotine; Quinolizines; Receptors, Nicotinic; Tumor Cells, Cultured | 1994 |
Alteration of brain nicotinic receptors induced by immobilization stress and nicotine in rats.
Topics: Alkaloids; Animals; Azocines; Brain Chemistry; Down-Regulation; Immobilization; Ligands; Male; Membranes; Nicotine; Nicotinic Agonists; Quinolizines; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Nicotinic; Stress, Psychological | 1995 |
Characterization of nicotinic acetylcholine receptors expressed in primary cultures of cerebellar granule cells.
Topics: Alkaloids; Animals; Autoradiography; Azocines; Calcium; Cells, Cultured; Cerebellum; Immunohistochemistry; Mice; Mice, Inbred Strains; Nicotine; Quinolizines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Time Factors | 1995 |
Pharmacological and physiological properties of a putative ganglionic nicotinic receptor, alpha 3 beta 4, expressed in transfected eucaryotic cells.
Topics: Acetylcholine; Alkaloids; Atropine; Azocines; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Kidney; Nicotine; Patch-Clamp Techniques; Quinolizines; Receptors, Nicotinic | 1995 |
Cytisine-induced behavioral activation: delineation of neuroanatomical locus of action.
Topics: Alkaloids; Animals; Azocines; Brain Mapping; Dopamine; Injections; Male; Motor Activity; Nicotine; Quinolizines; Rats; Ventral Tegmental Area | 1995 |
Regulation of alpha 4 beta 2 nicotinic acetylcholine receptors in M10 cells following treatment with nicotinic agents.
Topics: Alkaloids; Animals; Azocines; Cell Line; Dihydro-beta-Erythroidine; Hexamethonium; Mice; Models, Biological; Nicotine; Quinolizines; Receptors, Nicotinic; Tubocurarine | 1995 |
Nicotinic agonists administered into the fourth ventricle stimulate norepinephrine secretion in the hypothalamic paraventricular nucleus: an in vivo microdialysis study.
Topics: Alkaloids; Animals; Azocines; Brain Stem; Bungarotoxins; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Microdialysis; Nicotine; Norepinephrine; Paraventricular Hypothalamic Nucleus; Quinolizines; Rats; Rats, Inbred Strains | 1995 |
The effect of cholinoceptor agonists and neurotoxins on the release of vasopressin in the rat in relation to the subunit composition of the cholinoceptor.
Topics: Alkaloids; Animals; Azocines; Cholinergic Agents; Diuresis; Neurotoxins; Nicotine; Oxytocin; Quinolizines; Rats; Vasopressins | 1995 |
alpha-Bungarotoxin blocks the nicotinic receptor mediated increase in cell number in a neuroendocrine cell line.
Topics: Alkaloids; Azocines; Blotting, Northern; Bungarotoxins; Carcinoma, Small Cell; Cell Division; Humans; Iodine Radioisotopes; Lung Neoplasms; Neurosecretory Systems; Nicotine; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic; RNA, Messenger; Tubocurarine; Tumor Cells, Cultured | 1994 |
Working memory performance and cholinergic effects in the ventral tegmental area and substantia nigra.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Female; Maze Learning; Mecamylamine; Memory; Nicotine; Pilocarpine; Psychomotor Performance; Quinolizines; Rats; Rats, Sprague-Dawley; Scopolamine; Substantia Nigra; Ventral Tegmental Area | 1994 |
Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Binding Sites; Brain; Bungarotoxins; Cognition; Isoxazoles; Mice; Molecular Structure; Motor Activity; Nicotine; Quinolizines; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Stereoisomerism | 1994 |
Distribution of neuronal nicotinic receptor subunits in human brain.
Topics: Alkaloids; Animals; Autoradiography; Azocines; Base Sequence; Brain; Brain Chemistry; Chickens; Humans; In Situ Hybridization; Molecular Sequence Data; Neurons; Nicotine; Quinolizines; Rats; Receptors, Nicotinic; RNA, Messenger | 1994 |
Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension.
Topics: Aconitine; Alkaloids; Animals; Azocines; Blood Pressure; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Injections, Spinal; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spinal Cord; Stereotyped Behavior | 1994 |
(+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors.
Topics: Alkaloids; Analgesics; Animals; Azocines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Motor Activity; Nicotine; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rubidium Radioisotopes | 1994 |
Stimulatory pathways and sites of action of intrathecally administered nicotinic agents.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Blood Pressure; Heart Rate; Hemicholinium 3; Injections, Spinal; Male; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Sprague-Dawley; Spinal Cord; Sympathetic Nervous System; Trimethaphan | 1994 |
Clozapine attenuates the discriminative stimulus properties of (-)-nicotine.
Topics: Alkaloids; Anabasine; Animals; Azocines; Chlorisondamine; Clozapine; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Flupenthixol; Lobeline; Male; Motor Activity; Nicotine; Quinolizines; Rats; Rats, Wistar; Stereoisomerism | 1994 |
Cardiovascular and behavioral responses to nicotinic agents administered intrathecally.
Topics: Aconitine; Alkaloids; Animals; Atropine; Azocines; Behavior, Animal; Blood Pressure; Bungarotoxins; Cardiovascular System; Dihydro-beta-Erythroidine; Ganglionic Stimulants; Heart Rate; Injections, Spinal; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Nociceptors; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sensitivity and Specificity; Spinal Cord; Trimethaphan | 1994 |
Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine.
Topics: Alkaloids; Animals; Azocines; Binding Sites; Binding, Competitive; Ganglionic Stimulants; In Vitro Techniques; Kinetics; Ligands; Male; Membranes; Nicotine; Nicotinic Antagonists; Quinolizines; Rats; Receptors, Nicotinic; Sensitivity and Specificity; Spinal Cord; Tritium | 1994 |
In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Azocines; Bungarotoxins; Carbachol; Choline; Cholinergic Antagonists; Curare; Dimethylphenylpiperazinium Iodide; Guinea Pigs; Hair Cells, Auditory, Outer; In Vitro Techniques; Membrane Potentials; Nicotine; Piperidines; Pirenzepine; Quinolizines; Receptors, Cholinergic; Strychnine; Trimethaphan | 1994 |
Nicotine and acetylcholine induce release of calcitonin gene-related peptide from rat trachea.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Calcitonin Gene-Related Peptide; Capsaicin; Ganglionic Stimulants; Male; Nerve Endings; Neurons, Afferent; Nicotine; Quinolizines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Trachea | 1994 |
Epibatidine is a nicotinic analgesic.
Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Mecamylamine; Mice; Nicotine; Pyridines; Quinolizines; Rats; Receptors, Nicotinic | 1993 |
In vivo labeling of nicotinic cholinergic receptors in brain with [3H]cytisine.
Topics: Alkaloids; Animals; Azocines; Brain Chemistry; Male; Mice; Nicotine; Quinolizines; Radioligand Assay; Receptors, Nicotinic | 1994 |
Nicotinic receptor binding of [3H]cytisine, [3H]nicotine and [3H]methylcarbamylcholine in rat brain.
Topics: Alkaloids; Animals; Azocines; Brain; Carbachol; Dose-Response Relationship, Drug; Ligands; Male; Nicotine; Parasympathomimetics; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 1994 |
Nicotinic agonists modulate basal forebrain control of cortical cerebral blood flow in anesthetized rats.
Topics: Alkaloids; Animals; Azocines; Blood Pressure; Cerebral Cortex; Cerebrovascular Circulation; Glutamates; Heart Rate; Injections, Intravenous; Lobeline; Male; Nicotine; Parasympathomimetics; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Regional Blood Flow | 1993 |
Agonist pharmacology of the neuronal alpha 7 nicotinic receptor expressed in Xenopus oocytes.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Bacterial Toxins; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; DNA; Marine Toxins; Membrane Potentials; Microcystins; Neurons; Nicotine; Oocytes; Piperazines; Quaternary Ammonium Compounds; Quinolizines; Receptors, Nicotinic; Tropanes; Xenopus | 1993 |
Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test.
Topics: Alkaloids; Analysis of Variance; Animals; Anxiety; Azocines; Behavior, Animal; Drug Synergism; Ethanol; Injections, Intraperitoneal; Lobeline; Male; Mice; Motor Activity; Nicotine; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic | 1993 |
Residues 1 to 80 of the N-terminal domain of the beta subunit confer neuronal bungarotoxin sensitivity and agonist selectivity on neuronal nicotinic receptors.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Binding Sites; Bungarotoxins; Cross-Linking Reagents; Dimethylphenylpiperazinium Iodide; Glycosylation; Neurons; Nicotine; Quinolizines; Receptors, Nicotinic; Xenopus | 1993 |
Identification and functional significance of nicotinic cholinergic receptors in the rat pineal gland.
Topics: Alkaloids; Animals; Azocines; Bungarotoxins; Iodine Radioisotopes; Male; Melatonin; Nicotine; Norepinephrine; Organ Culture Techniques; Pineal Gland; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reference Values; Sexual Maturation; Tubocurarine | 1993 |
Nicotinic receptor agonists facilitate retention of avoidance training: participation of dopaminergic mechanisms.
Topics: Alkaloids; Animals; Avoidance Learning; Azocines; Cotinine; Flupenthixol; Injections, Intraperitoneal; Lobeline; Male; Nicotine; Quinolizines; Rats; Receptors, Dopamine; Receptors, Nicotinic; Retention, Psychology | 1993 |
Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.
Topics: Alkaloids; Animals; Azocines; Base Sequence; Cells, Cultured; DNA, Complementary; Humans; Kidney; Kinetics; Male; Molecular Sequence Data; Neurons; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Stereoisomerism; Transfection; Tritium; Up-Regulation | 1996 |
Application of [125I] (S)-5-iodonicotine, a new radioiodinated ligand, in the assay of nicotinic acetylcholine receptor binding in the brain.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Cerebral Cortex; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Kinetics; Ligands; Male; Membranes; Nicotine; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic | 1995 |
Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Bacterial Toxins; Citalopram; Corpus Striatum; Cyanobacteria Toxins; Hippocampus; In Vitro Techniques; Male; Marine Toxins; Microcystins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Potassium; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin Antagonists; Synaptosomes; Tetrodotoxin; Tritium; Tropanes | 1996 |
Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.
Topics: Alkaloids; Animals; Azocines; Conditioning, Operant; Dose-Response Relationship, Drug; Lobeline; Male; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Wistar; Reaction Time | 1996 |
Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Isoxazoles; Kinetics; Mice; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Temporal Lobe; Transfection | 1995 |
Cholinergic deafferentation enhances rat hippocampal pyramidal neuron responsiveness to locally applied nicotine.
Topics: Alkaloids; Animals; Azocines; Bungarotoxins; Choline O-Acetyltransferase; Denervation; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Nicotine; Pyramidal Cells; Quinolizines; Rats; Rats, Inbred F344; Receptors, Nicotinic; Reference Values | 1996 |
Chronic nicotine treatment delays the developmental increase in brain muscarinic receptors in rat neonate.
Topics: Aging; Alkaloids; Animals; Animals, Newborn; Azocines; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Female; Gene Expression Regulation, Developmental; Hippocampus; Lactation; Maternal-Fetal Exchange; Mesencephalon; Nicotine; Organ Specificity; Pregnancy; Prenatal Exposure Delayed Effects; Quinolizines; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Up-Regulation | 1996 |
Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells.
Topics: Alkaloids; Allosteric Site; Animals; Azocines; Cells, Cultured; Chickens; Cycloheximide; Fibroblasts; Gene Expression; Kinetics; Macromolecular Substances; Mecamylamine; Mice; Nicotine; Quinolizines; Receptors, Nicotinic; Recombinant Proteins; Tacrine; Transfection; Tubocurarine | 1996 |
Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Cholinergic Agonists; Dimethylphenylpiperazinium Iodide; Evoked Potentials; Glutamic Acid; Isoquinolines; Mecamylamine; Neurons; Nicotine; Patch-Clamp Techniques; Quinolizines; Rats; Rats, Wistar; Receptors, Cholinergic; Spinal Cord; Synaptic Transmission; Tetrodotoxin | 1996 |
Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Alkaloids; Animals; Arousal; Atropine; Azocines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Cations, Divalent; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; GABA Antagonists; gamma-Aminobutyric Acid; Ion Transport; Lobeline; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcystins; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium; Pyridazines; Pyridines; Quinolizines; Receptors, GABA-A; Receptors, Nicotinic; Tetrodotoxin; Thalamic Nuclei | 1997 |
Positive feedback modulation of acetylcholine release from isolated rat superior cervical ganglion.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Bungarotoxins; Choline; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Feedback; Female; Hexamethonium; In Vitro Techniques; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Rats; Superior Cervical Ganglion | 1997 |
Differential mechanisms involved in the effect of nicotinic agonists DMPP and lobeline to release [3H]5-HT from rat hippocampal slices.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Hippocampus; In Vitro Techniques; Kinetics; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tritium; Tubocurarine | 1996 |
Nicotinic acetylcholine receptor (nACh-R) agonist-induced changes in brain monoamine turnover in mice.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Dopamine; Isoxazoles; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyrrolidines; Quinolizines; Serotonin; Tacrine | 1997 |
Discriminative stimulus properties of the nicotinic agonist cytisine.
Topics: Alkaloids; Amphetamine; Animals; Azocines; Discrimination Learning; Dose-Response Relationship, Drug; Drug Antagonism; Generalization, Stimulus; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Rats | 1997 |
Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour.
Topics: Acetylcholine; Aging; Alkaloids; Animals; Animals, Newborn; Azocines; Dimethylphenylpiperazinium Iodide; Electric Conductivity; Ion Channel Gating; Membrane Potentials; Neurons; Nicotine; Oocytes; Patch-Clamp Techniques; Protein Multimerization; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Superior Cervical Ganglion; Time Factors; Xenopus laevis | 1997 |
Regulation of human alpha4beta2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways.
Topics: Alkaloids; Azocines; Binding Sites; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Humans; Ion Channels; Kidney; Ligands; Nicotine; Nicotinic Antagonists; Protein Kinase C; Quinolizines; Receptors, Nicotinic; Second Messenger Systems; Transfection; Tritium; Up-Regulation | 1997 |
Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain.
Topics: Alkaloids; Animals; Azocines; Brain; Drug Administration Schedule; Female; Kinetics; Male; Nicotine; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sex Characteristics; Time Factors; Up-Regulation | 1997 |
Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration.
Topics: Adrenal Glands; Alkaloids; Animals; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Male; Multivariate Analysis; Neurons; Nicotine; Nicotinic Agonists; Organ Specificity; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Thalamus; Up-Regulation | 1997 |
Behavioural and biochemical adaptations to nicotine in rats: influence of MK801, an NMDA receptor antagonist.
Topics: Alkaloids; Animals; Autoradiography; Azocines; Behavior, Animal; Brain; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Up-Regulation | 1997 |
Nicotine-stimulated release of [3H]norepinephrine from fetal rat locus coeruleus cells in culture.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Dimethylphenylpiperazinium Iodide; Fetus; Locus Coeruleus; N-Methylaspartate; Neurons; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium Chloride; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Rhombencephalon; Structure-Activity Relationship; Tetrodotoxin; Tritium | 1998 |
Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Azocines; Bungarotoxins; Cells, Cultured; Cerebral Cortex; Dihydro-beta-Erythroidine; Fetus; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Receptors, Nicotinic | 1998 |
5-[I-125/123]lodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors.
Topics: Alkaloids; Animals; Azetidines; Azocines; Binding Sites; Brain; Dose-Response Relationship, Drug; Iodine Radioisotopes; Male; Mecamylamine; Mice; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Quinolizines; Radionuclide Imaging; Receptors, Nicotinic; Scopolamine; Tissue Distribution | 1998 |
Evidence for presynaptic cholinergic receptors in sympathetic nerves in human dental pulp.
Topics: Adolescent; Adult; Alkaloids; Atropine; Azocines; Carbachol; Dental Pulp; Electric Stimulation; Enzyme Inhibitors; Female; Hexamethonium; Humans; Isotonic Solutions; Male; Muscarinic Agonists; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Quinolizines; Radiopharmaceuticals; Receptors, Muscarinic; Receptors, Nicotinic; Receptors, Presynaptic; Sympathetic Nervous System; Sympathomimetics; Tritium | 1998 |
Laminar distribution of nicotinic receptor subtypes in human cerebral cortex as determined by [3H](-)nicotine, [3H]cytisine and [3H]epibatidine in vitro autoradiography.
Topics: Aged; Aged, 80 and over; Alkaloids; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Humans; In Vitro Techniques; Kinetics; Male; Microtomy; Middle Aged; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic | 1998 |
Pharmacological characterization of nicotinic receptor-mediated acetylcholine release in rat brain--an in vivo microdialysis study.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Brain; Cotinine; Hippocampus; Injections, Intraperitoneal; Ligands; Lobeline; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Quinolizines; Rats; Rats, Inbred F344; Receptors, Nicotinic; Visual Cortex | 1998 |
Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord.
Topics: Aged; Aged, 80 and over; Alkaloids; Azocines; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; DNA Probes; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Medulla Oblongata; Mesencephalon; Middle Aged; Nicotine; Nicotinic Agonists; Peptidylprolyl Isomerase; Polymerase Chain Reaction; Pons; Pregnancy; Pregnancy Trimester, First; Protein Binding; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; RNA-Directed DNA Polymerase; RNA, Messenger; Spinal Cord; Tritium | 1998 |
Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.
Topics: Acetylcholine; Alkaloids; Anabasine; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; Dimethylphenylpiperazinium Iodide; Lobeline; Nicotine; Nicotinic Agonists; Oocytes; Protein Binding; Pyridines; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Xenopus laevis | 1998 |
Ligand binding and activation of rat nicotinic alpha4beta2 receptors stably expressed in HEK293 cells.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Calcium; Dihydro-beta-Erythroidine; Humans; Nicotine; Physostigmine; Quinolizines; Rats; Receptors, GABA-A; Receptors, Nicotinic; Recombinant Proteins | 1999 |
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists.
Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Hindlimb; Hot Temperature; Injections, Spinal; Lobeline; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Pain; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine; Vocalization, Animal | 1998 |
Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo.
Topics: Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Fluorine Radioisotopes; Frontal Lobe; Kinetics; Ligands; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus; Tissue Distribution | 1999 |
Nicotinic receptor binding sites in rat primary neuronal cells in culture: characterization and their regulation by chronic nicotine.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Binding, Competitive; Brain Chemistry; Brain Stem; Cells, Cultured; Cerebral Cortex; Dihydro-beta-Erythroidine; Female; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pregnancy; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tritium | 1999 |
Antidepressant effects of nicotine in an animal model of depression.
Topics: Alkaloids; Animals; Antidepressive Agents; Azocines; Binding Sites; Body Temperature; Bungarotoxins; Depression; Disease Models, Animal; Iodine Radioisotopes; Male; Motor Activity; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Receptors, Nicotinic; Tritium | 1999 |
Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line.
Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Azocines; Blotting, Northern; Bungarotoxins; Carbachol; Dimethylphenylpiperazinium Iodide; DNA, Complementary; Gene Expression; Humans; Insecticides; Iodine Radioisotopes; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Plasmids; Protein Synthesis Inhibitors; Quinolizines; Receptors, Nicotinic; Recombinant Proteins; RNA, Messenger; Tetracycline; Transfection; Tubocurarine; Tumor Cells, Cultured; Up-Regulation | 1999 |
Effects of nicotinic receptor agonists on beta-amyloid beta-sheet formation.
Topics: Alkaloids; Amyloid beta-Peptides; Azocines; Benzylidene Compounds; Hydrogen-Ion Concentration; Nicotine; Nicotinic Agonists; Protein Structure, Secondary; Pyridines; Quinolizines | 1999 |
Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.
Topics: Aging; Alkaloids; Animals; Axons; Azocines; Carbachol; Choline; Excitatory Postsynaptic Potentials; Mecamylamine; Metamorphosis, Biological; Models, Neurological; N-Methylaspartate; Nerve Regeneration; Neurons; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Quinolizines; Receptors, Cholinergic; Receptors, Nicotinic; Superior Colliculi; Vision, Binocular; Visual Pathways; Xenopus laevis | 1999 |
The role of beta 2-subunit-containing nicotinic acetylcholine receptors in the brain explored with a mutant mouse.
Topics: Alkaloids; Animals; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cognition; Dopamine Agonists; Mice; Mice, Knockout; Nicotine; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic | 1999 |
Effects of chronic treatment with (+)-nicotine on the stress-induced hypertension and downregulation of central nicotinic receptors in rats: comparative study with (-)-nicotine.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Blood Pressure; Brain; Down-Regulation; Ganglionic Stimulants; Hypertension; Male; Nicotine; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Stereoisomerism; Stress, Physiological; Tritium; Weight Gain | 1999 |
Nicotine blocks quinpirole-induced behavior in rats: psychiatric implications.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Bungarotoxins; Dopamine Agonists; Female; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Quinolizines; Quinpirole; Rats; Receptors, Nicotinic; Schizophrenia; Yawning | 1999 |
GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Animals; Azocines; Benzylidene Compounds; Cues; Discrimination Learning; Discrimination, Psychological; Generalization, Stimulus; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Rats; Rats, Long-Evans; Receptors, Nicotinic | 1999 |
The effect of cotinine on nicotine- and cocaine-induced dopamine release in the nucleus accumbens.
Topics: Alkaloids; Animals; Azocines; Brain Chemistry; Cocaine; Cotinine; Dopamine; Male; Nicotine; Nucleus Accumbens; Quinolizines; Rats; Rats, Sprague-Dawley | 1999 |
Autoradiographic comparison of [3H](-)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease.
Topics: Acetylcholine; Age Factors; Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Female; Humans; Male; Membrane Transport Proteins; Middle Aged; Nicotine; Piperidines; Pyridines; Quinolizines; Reference Values; Temporal Lobe; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1999 |
Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions.
Topics: Age Factors; Alkaloids; Animals; Azocines; Body Weight; Cerebral Cortex; Female; Hippocampus; Male; Mesencephalon; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sex Factors | 1999 |
Depressive characteristics of FSL rats: involvement of central nicotinic receptors.
Topics: Alkaloids; Animals; Antidepressive Agents; Azocines; Depression; Male; Mecamylamine; Nicotine; Quinolizines; Rats; Receptors, Nicotinic | 2000 |
Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Azocines; Binding, Competitive; Cerebral Cortex; Guinea Pigs; Hippocampus; Kinetics; Male; Nicotine; Peptide Fragments; Quinolizines; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Synaptic Membranes; Tritium | 2000 |
Genetic and pharmacological strategies identify a behavioral function of neuronal nicotinic receptors.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Behavior, Animal; Crosses, Genetic; Dose-Response Relationship, Drug; Female; Hippocampus; Humans; Hybridization, Genetic; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polymorphism, Restriction Fragment Length; Quinolizines; Receptors, Nicotinic; Seizures | 2000 |
Presynaptic nicotinic acetylcholine receptors in the myenteric plexus of guinea pig intestine.
Topics: Alkaloids; Animals; Azocines; Calcium; Electric Stimulation; Excitatory Postsynaptic Potentials; Guinea Pigs; Intestines; Magnesium; Male; Microinjections; Myenteric Plexus; Nicotine; Nicotinic Agonists; Peptide Fragments; Presynaptic Terminals; Quinolizines; Receptors, Neurokinin-3; Receptors, Nicotinic; Substance P; Tetrodotoxin | 2000 |
Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse.
Topics: Aggression; Alkaloids; Animals; Autoradiography; Azocines; Base Sequence; Body Constitution; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Exploratory Behavior; Female; Fertility; Habituation, Psychophysiologic; Homozygote; Male; Mice; Mice, Knockout; Molecular Sequence Data; Motor Activity; Neurons; Nicotine; Oligonucleotide Probes; Phenotype; Pyridines; Quinolizines; Receptors, Nicotinic; Restriction Mapping; Social Behavior; Tritium | 2000 |
Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine.
Topics: Alkaloids; Animals; Autoradiography; Azetidines; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Iodine Radioisotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic | 2000 |
Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dimethylphenylpiperazinium Iodide; Dopamine; Exocytosis; Male; Neostriatum; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Temperature | 2000 |
Effect of nicotine on cerebellar granule neuron development.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Cells, Cultured; Cellular Senescence; Cerebellum; DNA; Mice; Mice, Inbred ICR; Neurons; Nicotine; Nicotinic Agonists; Protein Isoforms; Pyridines; Quinolizines; Receptors, Cholinergic; Stem Cells | 2001 |
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anthraquinones; Antimycin A; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cotinine; Electron Transport Complex I; Electron Transport Complex II; Hexamethonium; Male; Membrane Proteins; Mitochondria; Mitochondrial Proton-Translocating ATPases; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Neuroprotective Agents; Nicotine; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Oxygen Consumption; Prosencephalon; Pyridines; Quinolizines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Nicotinic; Rotenone; Succinate Dehydrogenase; Superoxides; Synaptosomes | 2001 |
Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bacterial Toxins; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cells, Cultured; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; Hippocampus; Humans; Inhibitory Concentration 50; Marine Toxins; Microcystins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Tubocurarine; Tumor Cells, Cultured; Up-Regulation; Verapamil | 2001 |
Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain.
Topics: Alkaloids; Azocines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; RNA, Messenger; Smoking; Tritium; Up-Regulation | 2001 |
Characterization of human alpha4beta2 neuronal nicotinic receptors stably expressed in SH-EP1 cells.
Topics: Alkaloids; Azocines; Binding Sites; Binding, Competitive; Calcium; Cell Line; Fura-2; Humans; Intracellular Membranes; Mecamylamine; Neurons; Nicotine; Osmolar Concentration; Quinolizines; Receptors, Nicotinic; Time Factors; Up-Regulation | 2001 |
Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes.
Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Size; Cells, Cultured; DNA Primers; Electrophysiology; Ganglia, Spinal; Gene Expression; Insecticides; Neurons, Afferent; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Vasodilator Agents | 2001 |
Functional properties of human nicotinic AChRs expressed by IMR-32 neuroblastoma cells resemble those of alpha3beta4 AChRs expressed in permanently transfected HEK cells.
Topics: Acetylcholine; Alkaloids; Azocines; Cell Line; Dimethylphenylpiperazinium Iodide; Humans; Kidney; Neuroblastoma; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Quinolizines; Receptors, Nicotinic; Temperature; Transfection; Tumor Cells, Cultured | 2001 |
Protons enhance the gating kinetics of the alpha3/beta4 neuronal nicotinic acetylcholine receptor by increasing its apparent affinity to agonists.
Topics: Alkaloids; Azocines; Cells, Cultured; Electrophysiology; Humans; Hydrogen-Ion Concentration; Kinetics; Neurons; Nicotine; Nicotinic Agonists; Protons; Quinolizines; Receptors, Nicotinic; Transfection | 2002 |
Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice.
Topics: Alkaloids; Animals; Autoradiography; Azocines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Dopamine; Homozygote; Mice; Mice, Knockout; Mice, Mutant Strains; Nicotine; Nicotinic Antagonists; Organ Specificity; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Retinal Ganglion Cells; Tobacco Use Disorder; Visual Pathways | 2002 |
A non-alpha7 nicotinic acetylcholine receptor modulates excitatory input to hippocampal CA1 interneurons.
Topics: Acetylcholine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Choline; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Excitatory Postsynaptic Potentials; Hippocampus; Interneurons; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2002 |
First and second transmembrane segments of alpha3, alpha4, beta2, and beta4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine.
Topics: Alkaloids; Amino Acid Sequence; Amino Acid Substitution; Azocines; Electrophysiology; Humans; Membrane Proteins; Molecular Sequence Data; Mutation; Nicotine; Protein Subunits; Quinolizines; Receptors, Nicotinic; Sequence Homology, Amino Acid | 2002 |
Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Animals; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Agents; Ellipticines; In Vitro Techniques; Male; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Time Factors; Tomography, Emission-Computed | 2002 |
Autonomic function in mice lacking alpha5 neuronal nicotinic acetylcholine receptor subunit.
Topics: Alkaloids; Animals; Autonomic Nervous System; Azocines; Body Temperature Regulation; Crosses, Genetic; Dimethylphenylpiperazinium Iodide; Female; Heart Rate; Ileum; Male; Mice; Mice, Knockout; Morphine; Muscle Contraction; Muscle, Smooth; Neurons; Nicotine; Protein Subunits; Pupil; Quinolizines; Receptors, Nicotinic | 2002 |
Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dopamine; Hippocampus; Male; Membranes; Neostriatum; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium Chloride; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2002 |
Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates.
Topics: Alkaloids; Azocines; Binding Sites; Binding, Competitive; Cell Line, Transformed; Cell Membrane; Humans; Kidney; Nicotine; Nicotinic Agonists; Protein Binding; Quinolizines; Receptors, Nicotinic | 2003 |
Blockade of nicotine-induced locomotor sensitization by a novel neurotensin analog in rats.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Binding, Competitive; Brain; Dopamine; Dose-Response Relationship, Drug; Male; Motor Activity; Neurotensin; Nicotine; Norepinephrine; Peptide Fragments; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Tritium | 2003 |
Modulation of inhibitory synaptic activity by a non-alpha4beta2, non-alpha7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Alkaloids; Animals; Azocines; Choline; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Neural Inhibition; Nicotine; Nicotinic Agonists; Nootropic Agents; Patch-Clamp Techniques; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substantia Gelatinosa; Synaptic Transmission | 2003 |
Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.
Topics: Acetylcholine; Alkaloids; Amyloid beta-Peptides; Animals; Atropine; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Conotoxins; Dose-Response Relationship, Drug; Frontal Lobe; In Vitro Techniques; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Potassium; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Subcellular Fractions; Synaptosomes | 2003 |
Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Azocines; Binding Sites; Brain; Brain Mapping; Bridged Bicyclo Compounds, Heterocyclic; Diencephalon; Macaca mulatta; Male; Mesencephalon; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Telencephalon; Tissue Distribution | 2003 |
[The studies on tired and paralyzes superior cervical ganglion; effect of nicotine, anabasine, cytisine and lobeline].
Topics: Alkaloids; Anabasine; Azocines; Central Nervous System Stimulants; Ganglia, Autonomic; Lobeline; Nicotine; Quinolizines; Superior Cervical Ganglion | 1954 |
Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Prefrontal Cortex; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tetrodotoxin | 2003 |
Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; In Situ Hybridization; Male; Mecamylamine; Mouth Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Nicotinic; Trigeminal Ganglion | 2003 |
Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal.
Topics: Alkaloids; Animals; Azocines; Body Weight; Cerebral Cortex; Choline O-Acetyltransferase; Female; Male; Membrane Transport Proteins; Mesencephalon; Nicotine; Nicotinic Agonists; Parasympathetic Nervous System; Pregnancy; Prenatal Exposure Delayed Effects; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Substance Withdrawal Syndrome | 2004 |
Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty.
Topics: Alkaloids; Animals; Azocines; Bungarotoxins; Cerebellum; Chlorpyrifos; Cholinesterases; Drug Synergism; Female; Glial Fibrillary Acidic Protein; Insecticides; Male; Nicotine; Nicotinic Agonists; Parasympatholytics; Pirenzepine; Pregnancy; Prenatal Exposure Delayed Effects; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Sexual Maturation | 2004 |
A short synthesis of (+/-)-cytisine.
Topics: Alkaloids; Azocines; Molecular Structure; Nicotine; Quinolizines; Sparteine | 2004 |
Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Amino Acid Sequence; Animals; Antibodies; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Humans; Iodine Radioisotopes; Levodopa; Molecular Sequence Data; Nicotine; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Saimiri | 2005 |
Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization.
Topics: Alkaloids; Animals; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Drug Tolerance; Leucine; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Nicotine; Point Mutation; Pyridines; Quinolizines; Receptors, Nicotinic; Reward; Serine; Tobacco Use Disorder; Up-Regulation | 2004 |
Genetic correlation between the free-choice oral consumption of nicotine and alcohol in C57BL/6JxC3H/HeJ F2 intercross mice.
Topics: Alcohol Drinking; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bungarotoxins; Cerebral Cortex; Choice Behavior; Drinking; Ethanol; Female; Hippocampus; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Nicotine; Polymorphism, Genetic; Quinolizines; Receptors, Nicotinic; Sex Factors; Smoking; Species Specificity; Taste | 2005 |
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors.
Topics: Alkaloids; Azocines; Binding, Competitive; Biomarkers; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chromatography, Affinity; Chromatography, Liquid; Dextromethorphan; Mecamylamine; Membranes, Artificial; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic | 2005 |
Evidence for functional nicotinic receptors on pancreatic beta cells.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Azocines; Bungarotoxins; Cell Separation; Cell Survival; Cells, Cultured; Humans; Insulin; Islets of Langerhans; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tetrazolium Salts; Thiazoles | 2005 |
Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Azocines; Binding, Competitive; Cholinergic Agents; Cholinesterase Inhibitors; Dichlorvos; Dose-Response Relationship, Drug; Female; Galantamine; Humans; Membrane Potentials; Models, Biological; Nicotine; Oocytes; Phenylcarbamates; Physostigmine; Plasmids; Quinolizines; Receptors, Nicotinic; Rivastigmine; Scopolamine; Tacrine; Xenopus laevis | 2005 |
Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum.
Topics: Alkaloids; Azocines; Brain Stem; Cerebellum; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Male; Nicotine; Nicotinic Agonists; Pirenzepine; Pregnancy; Pregnancy Trimester, First; Prenatal Exposure Delayed Effects; Protein Binding; Quinolizines; Receptors, Muscarinic; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoking; Tritium | 2005 |
The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay.
Topics: Acetylcholine; Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Conotoxins; Dose-Response Relationship, Drug; Drug Interactions; Hydrogen-Ion Concentration; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Protein Subunits; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Time Factors | 2005 |
A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor.
Topics: Alkaloids; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Drug Evaluation, Preclinical; Embryo, Mammalian; Humans; Kidney; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Scintillation Counting | 2005 |
Subtypes of neuronal nicotinic acetylcholine receptors involved in nicotine-induced phosphorylation of extracellular signal-regulated protein kinase in PC12h cells.
Topics: Alkaloids; Animals; Azocines; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Phosphorylation; Protein Subunits; Quinolizines; Rats; Receptors, Nicotinic | 2006 |
Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line, Tumor; Cell Membrane; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Membrane Potentials; Nerve Tissue Proteins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Structure, Quaternary; Protein Transport; Pyridines; Quinolizines; Receptors, Nicotinic; Subcellular Fractions; Time Factors; Up-Regulation | 2005 |
Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release.
Topics: Alkaloids; Animals; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Signaling; Cell Membrane; Dimethylphenylpiperazinium Iodide; Insulin; Insulin-Secreting Cells; Insulinoma; Membrane Potentials; Mice; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic; Tumor Cells, Cultured | 2006 |
Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adolescent; Adult; Aged; Alkaloids; Analysis of Variance; Animals; Autoreceptors; Azocines; Calcium; Child; Child, Preschool; Domperidone; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Feedback; Female; Fluvoxamine; Humans; In Vitro Techniques; Isoxazoles; Male; Maprotiline; Mice; Middle Aged; Neocortex; Nicotine; Nicotinic Antagonists; Potassium; Pyrrolidines; Quinolizines; Rats; Receptors, Nicotinic; Sulpiride; Time Factors; Tritium | 2006 |
C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Calcium; Dopamine; Dose-Response Relationship, Drug; Female; Humans; Hydrocarbons, Brominated; Male; Membrane Potentials; Nicotine; Nicotinic Agonists; Norepinephrine; Oocytes; PC12 Cells; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Xenopus | 2006 |
Prenatal nicotine exposure alters the nicotinic receptor subtypes that modulate excitation of parasympathetic cardiac neurons in the nucleus ambiguus from primarily alpha3beta2 and/or alpha6betaX to alpha3beta4.
Topics: Alkaloids; Animals; Azocines; Basal Ganglia; Conotoxins; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Heart; Neurons; Nicotine; Nicotinic Antagonists; Parasympathetic Nervous System; Pregnancy; Prenatal Exposure Delayed Effects; Quinolizines; Rats; Receptors, Nicotinic; Synaptic Transmission; Vagus Nerve | 2006 |
alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine.
Topics: Acetylcholine; Alkaloids; Amino Acid Sequence; Animals; Azocines; Dose-Response Relationship, Drug; Humans; Molecular Sequence Data; Nicotine; Quinolizines; Receptors, Nicotinic; Xenopus laevis | 2006 |
Characterization of nicotinic acetylcholine receptors that modulate nicotine-evoked [3H]norepinephrine release from mouse hippocampal synaptosomes.
Topics: Alkaloids; Animals; Animals, Newborn; Azocines; Female; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neurotoxins; Nicotine; Nicotinic Agonists; Norepinephrine; Presynaptic Terminals; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptosomes; Tritium | 2006 |
Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors.
Topics: Acetylcholine; Alkaloids; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Electrophysiology; Epithelial Cells; Hexamethonium; Humans; Lobeline; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridines; Quinolizines; Receptors, Nicotinic; Transfection | 2006 |
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.
Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Membrane; Male; Mecamylamine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Nicotine; Nicotinic Antagonists; Pain; Pyridines; Quinolizines; Reaction Time; Receptors, Nicotinic; Spinal Cord | 2007 |
Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation.
Topics: Alkaloids; Animals; Azocines; Brain; Catecholamines; Corpus Striatum; Dimethylphenylpiperazinium Iodide; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Female; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neocortex; Nicotine; Nicotinic Agonists; Norepinephrine; Protein Subunits; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tetrodotoxin | 2007 |
Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats.
Topics: Alkaloids; Animals; Antipsychotic Agents; Attention; Azocines; Brain Chemistry; Bungarotoxins; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Nicotine; Nicotinic Agonists; Psychomotor Performance; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Signal Detection, Psychological | 2008 |
In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: implications for Parkinson's Disease.
Topics: Alkaloids; Animals; Antiparkinson Agents; Azocines; Bridged-Ring Compounds; Disease Models, Animal; Dopamine; Male; Microdialysis; Neostriatum; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Oxidopamine; Parkinsonian Disorders; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Substantia Nigra | 2008 |
Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Conditioning, Operant; Data Interpretation, Statistical; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Stimulus; Male; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Rats; Rats, Long-Evans; Receptors, Nicotinic; Varenicline | 2009 |
Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism.
Topics: Alcoholism; Alkaloids; Analysis of Variance; Animals; Antidepressive Agents; Azocines; Depression; Disease Models, Animal; Drug Administration Schedule; Male; Nicotine; Protein Binding; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Swimming; Tritium | 2009 |
Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons.
Topics: Acetylcholine; Aconitine; Action Potentials; Alkaloids; Animals; Azocines; Brain; Choline; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; Gene Expression; Kinetics; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Protein Subunits; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2009 |
Single-channel study of the binding-gating coupling in the slowly desensitizing chimeric alpha7-5HT3A receptor.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cattle; Cholinergic Agonists; Ion Channel Gating; Models, Biological; Nicotine; Patch-Clamp Techniques; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin 5-HT3 Receptor Agonists; Xenopus | 2009 |
Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects.
Topics: Alkaloids; Analysis of Variance; Azocines; Biotinylation; Cell Adhesion Molecules; Cell Line, Tumor; Cytokines; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Expression Regulation; Humans; Membrane Proteins; Neuroblastoma; NF-kappaB-Inducing Kinase; Nicotine; Nicotinic Agonists; Oligonucleotide Array Sequence Analysis; Protein Disulfide-Isomerases; Protein Serine-Threonine Kinases; Protein Transport; Quinolizines; Receptors, Nicotinic; RNA, Small Interfering; Time Factors; Transfection; Tritium | 2009 |
In silico characterization of cytisinoids docked into an acetylcholine binding protein.
Topics: Alkaloids; Animals; Azocines; Carrier Proteins; Computer Simulation; Crystallization; Lymnaea; Molecular Structure; Nicotine; Protein Binding; Pyridones; Quinolizines; Receptors, Nicotinic; X-Ray Diffraction | 2010 |
alpha4beta2 Nicotinic acetylcholine receptors, willing if able.
Topics: Acetylcholine; Alkaloids; Azetidines; Azocines; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Ion Channel Gating; Membrane Potentials; Models, Statistical; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Probability; Pyridines; Quinolizines; Receptors, Nicotinic; Time Factors | 2010 |
The neuronal nicotinic alpha4beta2 receptor has a high maximal probability of being open.
Topics: Acetylcholine; Alkaloids; Azetidines; Azocines; Cell Line; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Ion Channel Gating; Membrane Potentials; Models, Statistical; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Probability; Pyridines; Quinolizines; Receptors, Nicotinic; Time Factors; Transfection | 2010 |
The effects of nicotine, varenicline, and cytisine on schedule-controlled responding in mice: differences in α4β2 nicotinic receptor activation.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Reinforcement Schedule; Smoking Cessation; Time Factors; Varenicline | 2011 |
Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists.
Topics: Acetylcholine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzazepines; Bupropion; DNA, Complementary; Dopamine Uptake Inhibitors; Electrophysiological Phenomena; Humans; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pyridinium Compounds; Quinolizines; Quinoxalines; Receptors, Nicotinic; Smoking Cessation; Varenicline; Xenopus | 2011 |
Nicotinic receptor agonist-induced salivation and its cellular mechanism in parotid acini of rats.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Calcium; Male; Nicotine; Nicotinic Agonists; Norepinephrine; Parotid Gland; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Salivation | 2011 |
Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cell Line; Computer Simulation; Electric Organ; Humans; Ibogaine; Linear Models; Models, Molecular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo | 2011 |
Nicotine decreases food intake through activation of POMC neurons.
Topics: Alkaloids; Animals; Azocines; Eating; Ganglionic Stimulants; Male; Melanocortins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Pro-Opiomelanocortin; Quinolizines; Receptors, Nicotinic | 2011 |
A direct method and ICER tables for the estimation of the cost-effectiveness of smoking cessation interventions in general populations: application to a new cytisine trial and other examples.
Topics: Adult; Aged; Aged, 80 and over; Alkaloids; Azocines; Cost-Benefit Analysis; Female; Health Promotion; Humans; Life Expectancy; Life Tables; Male; Middle Aged; Models, Statistical; Nicotine; Quality-Adjusted Life Years; Quinolizines; Smoking; Smoking Cessation | 2012 |
Pharmacologic characterization of a nicotine-discriminative stimulus in rhesus monkeys.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Cocaine; Conditioning, Operant; Discrimination Learning; Dopamine Uptake Inhibitors; Drug Interactions; Female; Hypnotics and Sedatives; Macaca mulatta; Male; Mecamylamine; Midazolam; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Varenicline | 2012 |
Nicotinic receptor partial agonists alter catecholamine homeostasis and response to nicotine in PC12 cells.
Topics: Alkaloids; Animals; Azocines; Blotting, Northern; Catecholamines; Homeostasis; Neurons; Nicotine; Nicotinic Agonists; PC12 Cells; Quinolizines; Rats; Receptors, Nicotinic | 2012 |
Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.
Topics: Acetylcholine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aplysia; Azocines; Benzazepines; Binding Sites; Binding, Competitive; Carrier Proteins; Cell Line; HEK293 Cells; Humans; Kinetics; Ligands; Models, Molecular; Mutation; Nicotine; Nicotinic Agonists; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Quinolizines; Quinoxalines; Receptors, Nicotinic; Smoking Cessation; Varenicline | 2012 |
Use of an α3β4 nicotinic acetylcholine receptor subunit concatamer to characterize ganglionic receptor subtypes with specific subunit composition reveals species-specific pharmacologic properties.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Benzazepines; Drug Partial Agonism; Evoked Potentials; Ganglia; Humans; Ligands; Mutagenesis, Site-Directed; Mutant Proteins; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Protein Subunits; Quinolizines; Quinoxalines; Rats; Receptors, Nicotinic; Recombinant Fusion Proteins; Species Specificity; Varenicline; Xenopus laevis | 2012 |
Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures.
Topics: Alkaloids; Animals; Azocines; Cell Line, Tumor; Cell Membrane; Green Fluorescent Proteins; Mice; Nanostructures; Nicotine; Particle Size; Quinolizines; Receptors, Nicotinic; Receptors, Purinergic P2X2; Surface Properties | 2012 |
Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice.
Topics: Alcohol Drinking; Alkaloids; Animals; Azocines; Behavior, Addictive; Choice Behavior; Dihydro-beta-Erythroidine; Disease Models, Animal; Ethanol; Ligands; Lobeline; Male; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic; Signal Transduction | 2012 |
CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation.
Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Drug Partial Agonism; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Motor Activity; Nicotine; Nicotinic Agonists; Protein Binding; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Self Administration; Tobacco Use Cessation; Tobacco Use Disorder | 2013 |
[Crystal and molecular structure of cytisine salts].
Topics: Alkaloids; Azocines; Crystallization; Molecular Structure; Nicotine; Quinolizines; Receptors, Nicotinic; Salts | 2012 |
Multiple nicotine training doses in mice as a basis for differentiating the effects of smoking cessation aids.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Morphine; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Smoking Cessation; Tobacco Use Cessation Devices; Varenicline | 2013 |
Varenicline and cytisine diminish the dysphoric-like state associated with spontaneous nicotine withdrawal in rats.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Infusion Pumps, Implantable; Male; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Varenicline | 2014 |
Cytisine, the world's oldest smoking cessation aid.
Topics: Alkaloids; Azocines; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Nicotine; Quinolizines; Smoking Cessation; Tobacco Use Cessation Devices; Treatment Outcome | 2013 |
Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish.
Topics: Aconitine; Alkaloids; Animals; Azocines; Cholinergic Agents; Conotoxins; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Maze Learning; Mecamylamine; Memory; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic; Scopolamine; Swimming; Zebrafish; Zebrafish Proteins | 2014 |
[Safety of nicotine addiction treatment].
Topics: Abdominal Pain; Adult; Alkaloids; Azocines; Benzazepines; Boredom; Bupropion; Female; Headache; Humans; Male; Middle Aged; Nicotine; Patient Compliance; Quinolizines; Quinoxalines; Sleep Wake Disorders; Smoking Cessation; Tobacco Use Disorder; Varenicline; Xerostomia | 2013 |
α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration.
Topics: Alkaloids; Animals; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Down-Regulation; In Vitro Techniques; Mice; Mice, Knockout; Neostriatum; Nicotine; Nicotinic Agonists; Olfactory Bulb; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Synaptosomes | 2014 |
Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Azocines; Cholinergic Agonists; Female; Gene Expression; Humans; Membrane Potentials; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Quinolizines; Receptors, Nicotinic; Recombinant Fusion Proteins; Varenicline; Xenopus laevis | 2014 |
Cytisine--a tobacco treatment hiding in plain sight.
Topics: Alkaloids; Azocines; Female; Humans; Male; Nicotine; Quinolizines; Smoking Cessation; Tobacco Use Cessation Devices; Tobacco Use Disorder | 2014 |
Differential expression of the beta4 neuronal nicotinic receptor subunit affects tolerance development and nicotinic binding sites following chronic nicotine treatment.
Topics: Alkaloids; Animals; Azocines; Binding Sites; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Tolerance; Iodine Radioisotopes; Maze Learning; Mice; Mutation; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic | 2015 |
Agonist and antagonist effects of cytisine in vivo.
Topics: Alkaloids; Animals; Azocines; Discrimination, Psychological; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Rats, Wistar; Repetition Priming; Self Administration; Tobacco Use Disorder; Ventral Tegmental Area | 2015 |
Cytisine basicity, solvation, logP, and logD theoretical determination as tool for bioavailability prediction.
Topics: Alkaloids; Azocines; Biological Availability; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Chemical; Models, Molecular; Mucous Membrane; Nicotine; Permeability; Protons; Quinolizines; Solubility; Solutions; Thermodynamics; Tobacco Use Cessation Devices | 2016 |
A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice.
Topics: Acetyl Coenzyme A; Acetylcholinesterase; Age Factors; Alkaloids; Animals; Animals, Newborn; Azocines; Carbon Isotopes; Central Nervous System; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Female; Male; Mice; Nicotiana; Nicotine; Nicotinic Agonists; Protein Binding; Quinolizines; Receptors, Nicotinic; Sex Factors; Smoke; Tritium; Up-Regulation | 2016 |
Getting cytisine licensed for use world-wide: a call to action.
Topics: Alkaloids; Azocines; Legislation, Drug; Nicotine; Quinolizines; Smoking Cessation | 2016 |
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline | 2017 |
Cytisine for smoking cessation.
Topics: Alkaloids; Azocines; Humans; Meta-Analysis as Topic; Nicotine; Nicotinic Agonists; Quinolizines; Smoking Cessation; Systematic Reviews as Topic; Treatment Outcome | 2018 |
Differential cross-tolerance to the effects of nicotinic acetylcholine receptor drugs in C57BL/6J mice following chronic varenicline.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Conditioning, Operant; Drug Tolerance; Female; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Reinforcement, Psychology; Smoking Cessation; Varenicline | 2019 |
Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry.
Topics: Acetylcholine; Alkaloids; Animals; Azocines; Epilepsy, Frontal Lobe; Female; Mutation; Nicotine; Nicotinic Agonists; Oocytes; Quinolizines; Receptors, Nicotinic; Varenicline; Xenopus laevis | 2019 |
Measuring functional brain recovery in regenerating planarians by assessing the behavioral response to the cholinergic compound cytisine.
Topics: Alkaloids; Anesthetics, Local; Animals; Azocines; Brain; Carbachol; Cholinergic Agents; Cocaine; Cotinine; Dose-Response Relationship, Drug; Ethanol; Nicotine; Planarians; Quinolizines; Regeneration; Seizures | 2020 |
Reduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the α4β2 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine.
Topics: Alkaloids; Animals; Bridged-Ring Compounds; Ethanol; Female; Nicotine; Nicotinic Agonists; Rats; Receptors, Nicotinic | 2023 |
Nicotine and Cytisine Embryotoxicity in the Experimental Zebrafish Model.
Topics: Alkaloids; Animals; Azocines; Benzazepines; Humans; Nicotine; Nicotinic Agonists; Quinolizines; Quinoxalines; Receptors, Nicotinic; Varenicline; Zebrafish | 2023 |