nicotine has been researched along with coumarin in 21 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 12 (57.14) | 29.6817 |
2010's | 9 (42.86) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Topliss, JG; Yoshida, F | 1 |
Jolivette, LJ; Ward, KW | 1 |
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Inoue, K; Shimada, T; Yamazaki, H | 1 |
Cloak, CC; Lin, KM; Nuccio, I; Pechnick, RN; Poland, RE; Wan, YJ | 1 |
Aygün Kocabaş, N; Cholerton, S; Cok, I; Karakaya, AE; Sardaş, S | 1 |
Berthou, F; Dréano, Y; Le Gal, A; Lucas, D | 1 |
Cashman, JR; Fandrick, K; MacDougall, JM; Serafin, SV; Zhang, X | 1 |
Fujieda, M; Kamataki, T; Kiyotani, K; Peamkrasatam, S; Sriwatanakul, K; Yamazaki, H; Yoovathaworn, K | 1 |
Higashi, E; Katoh, M; Nakajima, M; Tokudome, S; Yokoi, T | 1 |
Ashton, M; Asimus, S; Hai, TN; Van Huong, N | 1 |
Rahnasto-Rilla, M; Raunio, H | 1 |
Murphy, SE; Retzlaff, C; von Weymarn, LB | 1 |
Cappendijk, SL; Miksys, S; Perry, WM; Tyndale, RF; Zhao, B | 1 |
van Dam, NM | 1 |
Chiba, M; Ishii, Y; Yamada, H; Yamamiya, I; Yoshisue, K | 1 |
Capelo, JL; Cavaleiro, JA; Faustino, MA; Lodeiro, C; Menezes, JC; Neves, Mda G; Oliveira, E; Santos, CI; Santos, HM | 1 |
Hirasawa, N; Hiratsuka, M; Hosono, H; Kumondai, M; Maekawa, M; Mano, N; Oda, A; Yamaguchi, H | 1 |
1 review(s) available for nicotine and coumarin
Article | Year |
---|---|
CYP2A6: genetics, structure, regulation, and function.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Mice; Models, Molecular; Multigene Family; Neoplasms; Nicotine; Nicotinic Agonists; Polymorphism, Genetic; Smoking; Substrate Specificity | 2012 |
2 trial(s) available for nicotine and coumarin
Article | Year |
---|---|
In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.
Topics: Administration, Oral; Adolescent; Adult; Anticoagulants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Drug Combinations; Female; Gene Frequency; Genotype; Humans; Hydroxyethylrutoside; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Nicotinic Agonists; Phenotype; Polymethacrylic Acids; Polymorphism, Genetic; Polyvinyls; Thailand; Tobacco Use Cessation Devices; Umbelliferones | 2006 |
Artemisinin and CYP2A6 activity in healthy subjects.
Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP2A6; Enzyme Induction; Humans; Male; Mixed Function Oxygenases; Nicotine; Tandem Mass Spectrometry; Umbelliferones; Vietnam | 2008 |
18 other study(ies) available for nicotine and coumarin
Article | Year |
---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians.
Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; DNA; DNA Primers; Gene Deletion; Genotype; Humans; Japan; Microsomes, Liver; Mixed Function Oxygenases; Mutation; Nicotine; Oxidation-Reduction; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; White People | 2000 |
Effect of cigarette smoking on coumarin metabolism in humans.
Topics: Administration, Oral; Adolescent; Adult; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Ganglionic Stimulants; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Smoking | 2000 |
Determination of coumarin metabolism in Turkish population.
Topics: Adult; Aged; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Gene Frequency; Genotype; Humans; Isoenzymes; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Phenotype; Point Mutation; Polymorphism, Genetic; Smoking; Turkey; Umbelliferones | 2001 |
Diversity of selective environmental substrates for human cytochrome P450 2A6: alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine.
Topics: Adult; Antibodies, Blocking; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Coumarins; Cytochrome P-450 CYP2A6; Diethylnitrosamine; Dimethylnitrosamine; Environmental Pollutants; Enzyme Inhibitors; Ethers; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Nicotine; Substrate Specificity | 2003 |
Inhibition of human liver microsomal (S)-nicotine oxidation by (-)-menthol and analogues.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Haplorhini; Humans; In Vitro Techniques; Menthol; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Smoking; Stereoisomerism; Steroid Hydroxylases | 2003 |
Inhibitory effects of neurotransmitters and steroids on human CYP2A6.
Topics: Aldehyde Oxidase; Androgens; Animals; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cell Line; Corticosterone; Coumarins; Cytochrome P-450 CYP2A6; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Estrogens; Histamine; Hormones; Humans; Hydroxylation; In Vitro Techniques; Insecta; Liver; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Neurotransmitter Agents; Nicotine; Norepinephrine; Phenotype; Recombinant Proteins; Serotonin; Tryptamines | 2007 |
CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5'(1')iminium ion.
Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Chromatography, High Pressure Liquid; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Humans; Kinetics; NADP; Nicotiana; Nicotine; Nicotinic Agonists; Oxidation-Reduction; Tritium | 2012 |
Nicotine kinetics in zebra finches in vivo and in vitro.
Topics: Animals; Brain; Coumarins; Finches; Humans; Male; Microsomes, Liver; Nicotine | 2013 |
Plant chemical ecology finally gets to its root(s).
Topics: Alkaloids; Coumarins; Cyclopentanes; Ecology; Nicotine; Oxylipins; Pheromones; Plant Roots; Plants; Signal Transduction | 2014 |
Effect of CYP2A6 genetic polymorphism on the metabolic conversion of tegafur to 5-fluorouracil and its enantioselectivity.
Topics: Cell Line; Coumarins; Cytochrome P-450 CYP2A6; DNA, Complementary; Escherichia coli; Fluorouracil; Humans; Microsomes, Liver; Nicotine; Polymorphism, Genetic; Sf9 Cells; Tegafur | 2014 |
Untangling interactions of a zinc(II) complex containing a coumarin-porphyrin unit with alkaloids in water solutions: a photophysical study.
Topics: Caffeine; Cotinine; Coumarins; Ethanol; Fresh Water; Molecular Structure; Nicotine; Photochemical Processes; Porphyrins; Portugal; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis; Ultraviolet Rays; Zinc | 2015 |
Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.
Topics: Alleles; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; HEK293 Cells; Humans; Hydroxylation; Kinetics; Microsomes; Models, Molecular; Nicotine; Oxidation-Reduction; Polymorphism, Genetic; Substrate Specificity; Transfection; Umbelliferones | 2017 |