Page last updated: 2024-08-26

nicotine and coumarin

nicotine has been researched along with coumarin in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	12 (57.14)	29.6817
2010's	9 (42.86)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Jolivette, LJ; Ward, KW	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Inoue, K; Shimada, T; Yamazaki, H	1
Cloak, CC; Lin, KM; Nuccio, I; Pechnick, RN; Poland, RE; Wan, YJ	1
Aygün Kocabaş, N; Cholerton, S; Cok, I; Karakaya, AE; Sardaş, S	1
Berthou, F; Dréano, Y; Le Gal, A; Lucas, D	1
Cashman, JR; Fandrick, K; MacDougall, JM; Serafin, SV; Zhang, X	1
Fujieda, M; Kamataki, T; Kiyotani, K; Peamkrasatam, S; Sriwatanakul, K; Yamazaki, H; Yoovathaworn, K	1
Higashi, E; Katoh, M; Nakajima, M; Tokudome, S; Yokoi, T	1
Ashton, M; Asimus, S; Hai, TN; Van Huong, N	1
Rahnasto-Rilla, M; Raunio, H	1
Murphy, SE; Retzlaff, C; von Weymarn, LB	1
Cappendijk, SL; Miksys, S; Perry, WM; Tyndale, RF; Zhao, B	1
van Dam, NM	1
Chiba, M; Ishii, Y; Yamada, H; Yamamiya, I; Yoshisue, K	1
Capelo, JL; Cavaleiro, JA; Faustino, MA; Lodeiro, C; Menezes, JC; Neves, Mda G; Oliveira, E; Santos, CI; Santos, HM	1
Hirasawa, N; Hiratsuka, M; Hosono, H; Kumondai, M; Maekawa, M; Mano, N; Oda, A; Yamaguchi, H	1

Reviews

1 review(s) available for nicotine and coumarin

Article	Year
CYP2A6: genetics, structure, regulation, and function. Drug metabolism and drug interactions, 2012, May-05, Volume: 27, Issue:2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Mice; Models, Molecular; Multigene Family; Neoplasms; Nicotine; Nicotinic Agonists; Polymorphism, Genetic; Smoking; Substrate Specificity	2012

Article

Year

CYP2A6: genetics, structure, regulation, and function.

Drug metabolism and drug interactions, 2012, May-05, Volume: 27, Issue:2

Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Mice; Models, Molecular; Multigene Family; Neoplasms; Nicotine; Nicotinic Agonists; Polymorphism, Genetic; Smoking; Substrate Specificity

2012

Trials

2 trial(s) available for nicotine and coumarin

Article	Year
In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais. Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Anticoagulants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Drug Combinations; Female; Gene Frequency; Genotype; Humans; Hydroxyethylrutoside; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Nicotinic Agonists; Phenotype; Polymethacrylic Acids; Polymorphism, Genetic; Polyvinyls; Thailand; Tobacco Use Cessation Devices; Umbelliferones	2006
Artemisinin and CYP2A6 activity in healthy subjects. European journal of clinical pharmacology, 2008, Volume: 64, Issue:3 Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP2A6; Enzyme Induction; Humans; Male; Mixed Function Oxygenases; Nicotine; Tandem Mass Spectrometry; Umbelliferones; Vietnam	2008

Article

Year

In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais.

Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:6

Topics: Administration, Oral; Adolescent; Adult; Anticoagulants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Drug Combinations; Female; Gene Frequency; Genotype; Humans; Hydroxyethylrutoside; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Nicotinic Agonists; Phenotype; Polymethacrylic Acids; Polymorphism, Genetic; Polyvinyls; Thailand; Tobacco Use Cessation Devices; Umbelliferones

2006

Artemisinin and CYP2A6 activity in healthy subjects.

European journal of clinical pharmacology, 2008, Volume: 64, Issue:3

Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coumarins; Cross-Over Studies; Cytochrome P-450 CYP2A6; Enzyme Induction; Humans; Male; Mixed Function Oxygenases; Nicotine; Tandem Mass Spectrometry; Umbelliferones; Vietnam

2008

Other Studies

18 other study(ies) available for nicotine and coumarin

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians. Archives of toxicology, 2000, Volume: 73, Issue:10-11 Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; DNA; DNA Primers; Gene Deletion; Genotype; Humans; Japan; Microsomes, Liver; Mixed Function Oxygenases; Mutation; Nicotine; Oxidation-Reduction; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; White People	2000
Effect of cigarette smoking on coumarin metabolism in humans. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2000, Volume: 2, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Ganglionic Stimulants; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Smoking	2000
Determination of coumarin metabolism in Turkish population. Human & experimental toxicology, 2001, Volume: 20, Issue:4 Topics: Adult; Aged; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Female; Gene Frequency; Genotype; Humans; Isoenzymes; Male; Middle Aged; Mixed Function Oxygenases; Nicotine; Phenotype; Point Mutation; Polymorphism, Genetic; Smoking; Turkey; Umbelliferones	2001
Diversity of selective environmental substrates for human cytochrome P450 2A6: alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine. Toxicology letters, 2003, Sep-15, Volume: 144, Issue:1 Topics: Adult; Antibodies, Blocking; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Coumarins; Cytochrome P-450 CYP2A6; Diethylnitrosamine; Dimethylnitrosamine; Environmental Pollutants; Enzyme Inhibitors; Ethers; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Nicotine; Substrate Specificity	2003
Inhibition of human liver microsomal (S)-nicotine oxidation by (-)-menthol and analogues. Chemical research in toxicology, 2003, Volume: 16, Issue:8 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Haplorhini; Humans; In Vitro Techniques; Menthol; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Smoking; Stereoisomerism; Steroid Hydroxylases	2003
Inhibitory effects of neurotransmitters and steroids on human CYP2A6. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:4 Topics: Aldehyde Oxidase; Androgens; Animals; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cell Line; Corticosterone; Coumarins; Cytochrome P-450 CYP2A6; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Estrogens; Histamine; Hormones; Humans; Hydroxylation; In Vitro Techniques; Insecta; Liver; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Neurotransmitter Agents; Nicotine; Norepinephrine; Phenotype; Recombinant Proteins; Serotonin; Tryptamines	2007
CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5'(1')iminium ion. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Chromatography, High Pressure Liquid; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Humans; Kinetics; NADP; Nicotiana; Nicotine; Nicotinic Agonists; Oxidation-Reduction; Tritium	2012
Nicotine kinetics in zebra finches in vivo and in vitro. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:6 Topics: Animals; Brain; Coumarins; Finches; Humans; Male; Microsomes, Liver; Nicotine	2013
Plant chemical ecology finally gets to its root(s). Journal of chemical ecology, 2014, Volume: 40, Issue:3 Topics: Alkaloids; Coumarins; Cyclopentanes; Ecology; Nicotine; Oxylipins; Pheromones; Plant Roots; Plants; Signal Transduction	2014
Effect of CYP2A6 genetic polymorphism on the metabolic conversion of tegafur to 5-fluorouracil and its enantioselectivity. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:9 Topics: Cell Line; Coumarins; Cytochrome P-450 CYP2A6; DNA, Complementary; Escherichia coli; Fluorouracil; Humans; Microsomes, Liver; Nicotine; Polymorphism, Genetic; Sf9 Cells; Tegafur	2014
Untangling interactions of a zinc(II) complex containing a coumarin-porphyrin unit with alkaloids in water solutions: a photophysical study. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2015, Volume: 14, Issue:4 Topics: Caffeine; Cotinine; Coumarins; Ethanol; Fresh Water; Molecular Structure; Nicotine; Photochemical Processes; Porphyrins; Portugal; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis; Ultraviolet Rays; Zinc	2015
Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities. Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:3 Topics: Alleles; Cotinine; Coumarins; Cytochrome P-450 CYP2A6; HEK293 Cells; Humans; Hydroxylation; Kinetics; Microsomes; Models, Molecular; Nicotine; Oxidation-Reduction; Polymorphism, Genetic; Substrate Specificity; Transfection; Umbelliferones	2017