nicotine has been researched along with cimetidine in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.50) | 18.7374 |
| 1990's | 15 (37.50) | 18.2507 |
| 2000's | 14 (35.00) | 29.6817 |
| 2010's | 8 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ganapathy, V; Leibach, FH; Prasad, PD; Wu, X | 1 |
| Fei, YJ; Ganapathy, V; Kekuda, R; Leibach, FH; Prasad, PD; Wang, H; Wu, X | 1 |
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Inui, KI; Masuda, S; Okuda, M; Saito, H; Urakami, Y | 1 |
| Inui, K; Okuda, M; Saito, H; Urakami, Y | 1 |
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Chen, J; Conway, SJ; Ganapathy, V; Huang, W; Leibach, FH; Prasad, PD; Rajan, DP; Seth, P; Wu, X | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Araki, Y; Eto, K; Furuno, K; Gomita, Y | 1 |
| Sitar, DS; Smyth, DD; Wong, LT | 1 |
| Bendayan, R; Frecker, RC; Sellers, EM; Shaw, C; Sullivan, JT | 1 |
| Bommer, M; Herz, A; Liebisch, D; Noble, EP | 1 |
| DeMarco, GJ; Howard, PC; McCoy, GD | 1 |
| Kusunoki, M; Tanaka, C; Taniyama, K | 1 |
| Berkman, CE; Cashman, JR; Cashman, LE; Park, SB | 1 |
| Seaton, MJ; Vesell, ES | 1 |
| Bendayan, R; Frecker, RC; Kennedy, G; Sellers, EM | 1 |
| Ea-Kim, L; Javellaud, J; Oudart, N | 1 |
| Eidi, A; Eidi, M; Oryan, S; Parivar, K; Zarrindast, MR | 1 |
| O'Donnell, MJ; Plaumann, JS; Rheault, MR | 1 |
3 review(s) available for nicotine and cimetidine
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans.
Topics: Adult; Animals; Cimetidine; Gene Expression Regulation, Enzymologic; Humans; Liver; Nicotine; Oxidation-Reduction; Oxygenases; Safrole; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity; Swine | 1995 |
Variables affecting nicotine metabolism.
Topics: Aging; Animals; Cimetidine; Dietary Proteins; Drug Interactions; Ethanol; Female; Genetic Variation; Humans; Nicotine; Pregnancy; Smoking; Species Specificity | 1993 |
2 trial(s) available for nicotine and cimetidine
| Article | Year |
|---|---|
Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans.
Topics: Adult; Cimetidine; Cotinine; Double-Blind Method; Humans; Injections, Intravenous; Liver; Male; Middle Aged; Nicotine; Random Allocation; Ranitidine | 1990 |
Lack of effect of cimetidine on cigarette smoking.
Topics: Carbon Monoxide; Cimetidine; Cotinine; Double-Blind Method; Female; Humans; Male; Nicotine; Smoking; Smoking Cessation | 1993 |
35 other study(ies) available for nicotine and cimetidine
| Article | Year |
|---|---|
cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family.
Topics: Amines; Amino Acid Sequence; Base Sequence; Biological Transport; Carrier Proteins; Chromosomes, Human, Pair 5; Cloning, Molecular; DNA, Complementary; Guanidines; Human Genome Project; Humans; Ions; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Pyridines; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Solute Carrier Family 22 Member 5; Symporters; Tetraethylammonium | 1998 |
Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta.
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; DNA-Binding Proteins; HeLa Cells; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Octamer Transcription Factor-3; Oocytes; Placenta; Protein Conformation; Rats; Transcription Factors; Xenopus laevis | 1998 |
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.
Topics: Animals; Base Sequence; Carrier Proteins; Cations; Cell Line; Cell Membrane; DNA Primers; Dogs; Kidney Tubules; Membrane Proteins; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Tetraethylammonium | 1998 |
Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Buffers; Carrier Proteins; Cells, Cultured; Hydrogen-Ion Concentration; Levofloxacin; Membrane Proteins; Ofloxacin; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Potassium; Rats; Tetraethylammonium; Transfection; Xenopus laevis | 1999 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter.
Topics: Acetylcarnitine; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Humans; In Situ Hybridization; Kidney; Membrane Proteins; Mice; Myocardium; Organ Specificity; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Effects of exposure to standard- and nicotine-reduced-cigarette smoke on pharmacokinetics of theophylline and cimetidine in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Male; Nicotine; Rats; Rats, Wistar; Smoking; Theophylline | 1992 |
Interference with renal organic cation transport by (-)- and (+)-nicotine at concentrations documented in plasma of habitual tobacco smokers.
Topics: Amantadine; Animals; Cimetidine; Cotinine; Humans; Kidney Cortex; Kidney Tubules; Male; Nicotine; Rats; Rats, Inbred Strains; Smoking; Stereoisomerism | 1992 |
H1-histaminergic activation of catecholamine release by chromaffin cells.
Topics: Adrenal Medulla; Animals; Biological Transport, Active; Calcium; Catecholamines; Cattle; Cells, Cultured; Cimetidine; Clemastine; Histamine; Hormones; Kinetics; Muscarine; Nicotine; Norepinephrine; Ranitidine; Receptors, Histamine; Receptors, Histamine H1 | 1988 |
Characterization of hamster liver nicotine metabolism. I. Relative rates of microsomal C and N oxidation.
Topics: Animals; Chromatography, High Pressure Liquid; Cimetidine; Cotinine; Cricetinae; Cyanides; Cysteamine; Male; Mesocricetus; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Nicotine; Oxidation-Reduction; Papain; Peptide Hydrolases; Proadifen | 1986 |
Inhibitory histamine H2-receptor in the guinea-pig urinary bladder.
Topics: Acetylcholine; Animals; Calcium; Choline; Cimetidine; Diphenhydramine; Electric Stimulation; Female; Guinea Pigs; Histamine; Imidazoles; Impromidine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Pyrilamine; Receptors, Histamine; Receptors, Histamine H2; Scopolamine; Tetrodotoxin; Urinary Bladder | 1984 |
Reduction of the pressor response to nicotine in the guinea pigs by a histamine (H3) agonist is attenuated by an inhibitor of nitric oxide synthesis.
Topics: Adrenalectomy; Animals; Arginine; Blood Pressure; Cimetidine; Guinea Pigs; Heart Rate; Histamine; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; NG-Nitroarginine Methyl Ester; Nicotine; Nitric Oxide Synthase; Piperidines | 1996 |
Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats.
Topics: Acetylcholine; Animals; Avoidance Learning; Cimetidine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Memory; Muscarinic Antagonists; Nicotine; Pyrilamine; Rats; Rats, Wistar; Reaction Time; Receptors, Cholinergic; Receptors, Histamine; Retention, Psychology; Scopolamine | 2003 |
Tetraethylammonium and nicotine transport by the Malpighian tubules of insects.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, Thin Layer; Cimetidine; Female; In Vitro Techniques; Insecta; Male; Malpighian Tubules; Niacinamide; Nicotine; Quinidine; Rhodnius; Tetraethylammonium; Time Factors | 2006 |