Page last updated: 2024-08-26

nicotine and baclofen

nicotine has been researched along with baclofen in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.63)18.7374
1990's2 (5.26)18.2507
2000's18 (47.37)29.6817
2010's15 (39.47)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Castro, E; González, MP; Oset-Gasque, MJ1
Amitai, Y; Connors, BW; Gil, Z1
Ahang, S; Sabetkasai, M; Shafaghi, B; Zarrindast, MR1
Bartolini, A; Bellucci, C; Dei, S; Galeotti, N; Ghelardini, C; Gualtieri, F; Manetti, D; Romanelli, MN; Scapecchi, S; Teodori, E1
Cousins, MS; de Wit, H; Stamat, HM1
Bevins, RA; Palmatier, MI1
Alva, H; Blednov, YA; Harris, RA; Stoffel, M1
Greenfield, SA; Mann, EO1
Collu, M; Fadda, P; Fratta, W; Fresu, A; Scherma, M1
Froestl, W; Markou, A; Paterson, NE1
Amantea, D; Bowery, NG; Tessari, M1
Amantea, D; Bowery, NG1
Icenogle, L; Levin, ED; Weber, E1
Chan, SW; Li, P; Lin, G; Rudd, JA1
Bienkowski, P; Korkosz, A; Kostowski, W; Plaznik, A; Taracha, E; Zatorski, P1
Chiappinelli, VA; Guo, JZ; Liu, YB1
Goldberg, SR; Le Foll, B; Wertheim, CE1
Cossu, G; Fadda, P; Fattore, L; Fratta, W; Scherma, M; Spano, MS1
Forget, B; Le Foll, B; Pushparaj, A1
Balerio, GN; Calvo, M; Moutinho, LM; Varani, AP1
Balerio, GN; Varani, AP1
Cheng, K; Koek, W; Rice, KC1
Balerio, GN; Bettler, B; Pedrón, VT; Varani, AP1
Aso, E; Balerio, GN; Maldonado, R; Moutinho, LM; Varani, AP1
Falco, AM; McDonald, CG; Smith, RF1
Aso, E; Balerio, GN; Maldonado, R; Varani, AP1
Balerio, GN; Moutinho Machado, L; Varani, AP1
Al-Wadei, HA; Al-Wadei, MH; Banerjee, J; Dagnon, K; Schuller, HM1
Sharp, BM; Yu, G1
Boehm, SL; Frazee, AM; Kasten, CR1
Boettiger, CA; Palmatier, MI; Robinson, DL; Stringfield, SJ1
Candiotti, KA; Gitlin, M; Rodriguez-Blanco, YF; Sevilla, A; Su, C; Weller, R; Wu, J; Yang, J; Zhang, Y; Zheng, C1
Barker, D; Cro, S; Lingford-Hughes, AR; Mozgunov, P; Nahar, L; Paterson, LM; Paterson, S; Phillips, R; Smith, C1

Trials

2 trial(s) available for nicotine and baclofen

ArticleYear
Effects of a single dose of baclofen on self-reported subjective effects and tobacco smoking.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2001, Volume: 3, Issue:2

    Topics: Acute Disease; Adult; Affect; Baclofen; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Humans; Male; Nicotine; Self Disclosure; Severity of Illness Index; Smoking Cessation; Smoking Prevention; Substance Withdrawal Syndrome; Surveys and Questionnaires; Tobacco Use Disorder

2001
FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study.
    Trials, 2022, Oct-18, Volume: 23, Issue:1

    Topics: Analgesics, Opioid; Baclofen; Bayes Theorem; Carbon Dioxide; Cholecalciferol; GABA-B Receptor Agonists; Humans; Hypnotics and Sedatives; Methadone; Nicotine; Opiate Substitution Treatment; Opioid-Related Disorders; Single-Blind Method; Vitamin D

2022

Other Studies

36 other study(ies) available for nicotine and baclofen

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
GABAA and GABAB receptors are functionally active in the regulation of catecholamine secretion by bovine chromaffin cells.
    Journal of neuroscience research, 1989, Volume: 23, Issue:3

    Topics: Adrenal Medulla; Animals; Baclofen; Bicuculline; Catecholamines; Cattle; In Vitro Techniques; Muscimol; Nicotine; Receptors, GABA-A

1989
Differential regulation of neocortical synapses by neuromodulators and activity.
    Neuron, 1997, Volume: 19, Issue:3

    Topics: Animals; Baclofen; Cholinergic Fibers; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Mecamylamine; Mice; Mice, Inbred Strains; Muscarinic Agonists; Neocortex; Neurons, Afferent; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organophosphorus Compounds; Pyramidal Cells; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Thalamus

1997
Baclofen-induced antinociception and nicotinic receptor mechanism(s).
    Pharmacology & toxicology, 1999, Volume: 85, Issue:5

    Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Hexamethonium; Male; Mice; Nicotine; Organophosphorus Compounds; Pain Measurement; Receptors, Nicotinic; Time Factors

1999
Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents.
    Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10

    Topics: Adrenergic alpha-Agonists; Amnesia; Animals; Avoidance Learning; Baclofen; Clonidine; Dose-Response Relationship, Drug; Drug Design; GABA Agonists; Mecamylamine; Mice; Molecular Structure; Muscarinic Antagonists; Nicotine; Nootropic Agents; Piperazines; Piracetam; Pyrroles; Scopolamine

2000
Examination of GABAergic and dopaminergic compounds in the acquisition of nicotine-conditioned hyperactivity in rats.
    Neuropsychobiology, 2002, Volume: 45, Issue:2

    Topics: Animals; Baclofen; Benzazepines; Conditioning, Classical; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; GABA Agonists; GABA-B Receptor Antagonists; Male; Motor Activity; Muscle Relaxants, Central; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, GABA-B; Salicylamides

2002
A pervasive mechanism for analgesia: activation of GIRK2 channels.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Jan-07, Volume: 100, Issue:1

    Topics: Analgesia; Analgesics; Animals; Baclofen; Benzoxazines; Clonidine; Crosses, Genetic; Ethanol; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Mutagenesis; Naphthalenes; Nicotine; Oxotremorine; Pain; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Sex Characteristics

2003
Novel modulatory mechanisms revealed by the sustained application of nicotine in the guinea-pig hippocampus in vitro.
    The Journal of physiology, 2003, Sep-01, Volume: 551, Issue:Pt 2

    Topics: 2-Amino-5-phosphonovalerate; alpha7 Nicotinic Acetylcholine Receptor; Animals; Baclofen; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Picrotoxin; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic

2003
Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat.
    Synapse (New York, N.Y.), 2003, Volume: 50, Issue:1

    Topics: Animals; Baclofen; Cocaine; Dopamine; Dose-Response Relationship, Drug; Extracellular Fluid; GABA Agonists; GABA-B Receptor Agonists; Male; Microdialysis; Morphine; Neural Pathways; Nicotine; Nucleus Accumbens; Rats; Receptors, GABA-B; Reward; Substance-Related Disorders; Synaptic Transmission; Up-Regulation

2003
The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat.
    Psychopharmacology, 2004, Volume: 172, Issue:2

    Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid; Male; Nicotine; Organophosphonates; Phosphinic Acids; Rats; Rats, Wistar; Self Administration

2004
Reduced G-protein coupling to the GABAB receptor in the nucleus accumbens and the medial prefrontal cortex of the rat after chronic treatment with nicotine.
    Neuroscience letters, 2004, Jan-30, Volume: 355, Issue:3

    Topics: Animals; Baclofen; GABA-B Receptor Agonists; GTP-Binding Proteins; Male; Nicotine; Nucleus Accumbens; Prefrontal Cortex; Protein Binding; Rats; Rats, Wistar; Receptors, GABA-B

2004
Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration.
    BMC pharmacology, 2004, Oct-20, Volume: 4

    Topics: Animals; Baclofen; Calcium; Dopamine; Drug Interactions; GABA Agonists; In Vitro Techniques; Male; Nicotine; Rats; Rats, Wistar; Tetrodotoxin; Tritium; Ventral Tegmental Area

2004
Baclofen interactions with nicotine in rats: effects on memory.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 79, Issue:2

    Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agonists; Maze Learning; Memory; Nicotine; Rats; Rats, Sprague-Dawley

2004
Action of anti-tussive drugs on the emetic reflex of Suncus murinus (house musk shrew).
    European journal of pharmacology, 2007, Mar-22, Volume: 559, Issue:2-3

    Topics: Analysis of Variance; Animals; Antiemetics; Antitussive Agents; Baclofen; Cevanes; Codeine; Copper Sulfate; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Motion Sickness; Nicotine; Reflex; Scopolamine; Shrews; Vomiting

2007
Ethanol blocks nicotine-induced seizures in mice: comparison with midazolam and baclofen.
    Alcohol (Fayetteville, N.Y.), 2006, Volume: 40, Issue:3

    Topics: Animals; Anticonvulsants; Baclofen; Central Nervous System Depressants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Ethanol; GABA Agents; Male; Mice; Mice, Inbred C57BL; Midazolam; Motor Activity; Nicotine

2006
Nicotinic receptor-mediated biphasic effect on neuronal excitability in chick lateral spiriform neurons.
    Neuroscience, 2007, Sep-21, Volume: 148, Issue:4

    Topics: Action Potentials; Animals; Baclofen; Brain; Calcium; Carbachol; Chick Embryo; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; In Vitro Techniques; Neural Inhibition; Neurons; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Time Factors

2007
Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats.
    Neuroscience letters, 2008, Oct-10, Volume: 443, Issue:3

    Topics: Animals; Baclofen; Behavior, Animal; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward

2008
Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:7

    Topics: Animals; Baclofen; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Drug Administration Schedule; Extinction, Psychological; GABA Agonists; Male; Mice; Mice, Inbred C57BL; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Tobacco Use Disorder

2009
Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction.
    Biological psychiatry, 2010, Aug-01, Volume: 68, Issue:3

    Topics: Analysis of Variance; Animals; Association Learning; Baclofen; Behavior, Addictive; Behavior, Animal; Cerebral Cortex; Conditioning, Classical; Disease Models, Animal; Drug Combinations; Extinction, Psychological; GABA Agonists; Male; Microinjections; Motivation; Muscimol; Nicotine; Nicotinic Agonists; Rats; Reinforcement Schedule; Self Administration; Tobacco Use Disorder

2010
Ability of baclofen to prevent somatic manifestations and neurochemical changes during nicotine withdrawal.
    Drug and alcohol dependence, 2011, Dec-01, Volume: 119, Issue:1-2

    Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Smoking Cessation; Substance Withdrawal Syndrome; Time Factors

2011
GABA(B) receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice.
    Pharmacological research, 2012, Volume: 65, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Baclofen; Behavior, Animal; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Maze Learning; Mice; Motor Activity; Nicotine; Receptors, GABA-B; Tobacco Use Disorder

2012
Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:3

    Topics: Animals; Baclofen; Benzodiazepines; Benzofurans; Cocaine; Columbidae; Diazepam; Discrimination, Psychological; Ethanol; GABA-B Receptor Agonists; Illicit Drugs; Nicotine; Organophosphorus Compounds; Phenols; Sodium Oxybate

2013
Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.
    Neuropharmacology, 2014, Volume: 81

    Topics: Analysis of Variance; Animals; Anxiety; Baclofen; Disease Models, Animal; Dorsal Raphe Nucleus; Dose-Response Relationship, Drug; GABA-B Receptor Antagonists; Gene Expression Regulation; Male; Mice; Mice, Knockout; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Receptors, GABA-B; Septal Nuclei

2014
Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations.
    Psychopharmacology, 2014, Volume: 231, Issue:15

    Topics: Animals; Anxiety; Avoidance Learning; Baclofen; Conditioning, Psychological; GABA-B Receptor Agonists; Male; Mice; Movement; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Receptors, GABA-B; Reward; Space Perception; Substance Withdrawal Syndrome; Tobacco Use Disorder

2014
Anxiety status affects nicotine- and baclofen-induced locomotor activity, anxiety, and single-trial conditioned place preference in male adolescent rats.
    Developmental psychobiology, 2014, Volume: 56, Issue:6

    Topics: Animals; Anxiety; Association Learning; Baclofen; Behavior, Animal; Cholinergic Agents; Conditioning, Operant; GABA-B Receptor Agonists; Male; Motor Activity; Nicotine; Rats

2014
Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine.
    European journal of pharmacology, 2014, Sep-05, Volume: 738

    Topics: Analgesics; Animals; Baclofen; Drug Interactions; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Mice; Motor Activity; Nicotine

2014
Baclofen prevented the changes in c-Fos and brain-derived neutrophic factor expressions during mecamylamine-precipitated nicotine withdrawal in mice.
    Synapse (New York, N.Y.), 2014, Volume: 68, Issue:11

    Topics: Animals; Baclofen; Basal Ganglia; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organ Specificity; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome

2014
Differential modulation of nicotine-induced gemcitabine resistance by GABA receptor agonists in pancreatic cancer cell xenografts and in vitro.
    BMC cancer, 2014, Sep-27, Volume: 14

    Topics: Animals; Baclofen; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; GABA Agonists; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Male; Mice; Mice, Nude; Nicotine; Pancreatic Neoplasms; Xenograft Model Antitumor Assays

2014
Basolateral amygdala and ventral hippocampus in stress-induced amplification of nicotine self-administration during reacquisition in rat.
    Psychopharmacology, 2015, Volume: 232, Issue:15

    Topics: Animals; Baclofen; Basolateral Nuclear Complex; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Hippocampus; Male; Muscimol; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration

2015
Developing a model of limited-access nicotine consumption in C57Bl/6J mice.
    Pharmacology, biochemistry, and behavior, 2016, Volume: 148

    Topics: Animals; Baclofen; Ethanol; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Models, Animal; Nicotine; Saccharin; Self Administration

2016
Orbitofrontal participation in sign- and goal-tracking conditioned responses: Effects of nicotine.
    Neuropharmacology, 2017, Volume: 116

    Topics: Action Potentials; Animals; Attention; Baclofen; Conditioning, Classical; Cues; GABA Agonists; Goals; Male; Muscimol; Neurons; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, GABA

2017
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
    Neuroscience letters, 2020, 01-10, Volume: 715

    Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Male; Naloxone; Nicotine; Pain Perception; Pain Threshold; Rats; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome; Time Factors; Up-Regulation

2020