nicotine has been researched along with baclofen in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 18 (47.37) | 29.6817 |
| 2010's | 15 (39.47) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Castro, E; González, MP; Oset-Gasque, MJ | 1 |
| Amitai, Y; Connors, BW; Gil, Z | 1 |
| Ahang, S; Sabetkasai, M; Shafaghi, B; Zarrindast, MR | 1 |
| Bartolini, A; Bellucci, C; Dei, S; Galeotti, N; Ghelardini, C; Gualtieri, F; Manetti, D; Romanelli, MN; Scapecchi, S; Teodori, E | 1 |
| Cousins, MS; de Wit, H; Stamat, HM | 1 |
| Bevins, RA; Palmatier, MI | 1 |
| Alva, H; Blednov, YA; Harris, RA; Stoffel, M | 1 |
| Greenfield, SA; Mann, EO | 1 |
| Collu, M; Fadda, P; Fratta, W; Fresu, A; Scherma, M | 1 |
| Froestl, W; Markou, A; Paterson, NE | 1 |
| Amantea, D; Bowery, NG; Tessari, M | 1 |
| Amantea, D; Bowery, NG | 1 |
| Icenogle, L; Levin, ED; Weber, E | 1 |
| Chan, SW; Li, P; Lin, G; Rudd, JA | 1 |
| Bienkowski, P; Korkosz, A; Kostowski, W; Plaznik, A; Taracha, E; Zatorski, P | 1 |
| Chiappinelli, VA; Guo, JZ; Liu, YB | 1 |
| Goldberg, SR; Le Foll, B; Wertheim, CE | 1 |
| Cossu, G; Fadda, P; Fattore, L; Fratta, W; Scherma, M; Spano, MS | 1 |
| Forget, B; Le Foll, B; Pushparaj, A | 1 |
| Balerio, GN; Calvo, M; Moutinho, LM; Varani, AP | 1 |
| Balerio, GN; Varani, AP | 1 |
| Cheng, K; Koek, W; Rice, KC | 1 |
| Balerio, GN; Bettler, B; Pedrón, VT; Varani, AP | 1 |
| Aso, E; Balerio, GN; Maldonado, R; Moutinho, LM; Varani, AP | 1 |
| Falco, AM; McDonald, CG; Smith, RF | 1 |
| Aso, E; Balerio, GN; Maldonado, R; Varani, AP | 1 |
| Balerio, GN; Moutinho Machado, L; Varani, AP | 1 |
| Al-Wadei, HA; Al-Wadei, MH; Banerjee, J; Dagnon, K; Schuller, HM | 1 |
| Sharp, BM; Yu, G | 1 |
| Boehm, SL; Frazee, AM; Kasten, CR | 1 |
| Boettiger, CA; Palmatier, MI; Robinson, DL; Stringfield, SJ | 1 |
| Candiotti, KA; Gitlin, M; Rodriguez-Blanco, YF; Sevilla, A; Su, C; Weller, R; Wu, J; Yang, J; Zhang, Y; Zheng, C | 1 |
| Barker, D; Cro, S; Lingford-Hughes, AR; Mozgunov, P; Nahar, L; Paterson, LM; Paterson, S; Phillips, R; Smith, C | 1 |
2 trial(s) available for nicotine and baclofen
| Article | Year |
|---|---|
Effects of a single dose of baclofen on self-reported subjective effects and tobacco smoking.
Topics: Acute Disease; Adult; Affect; Baclofen; Dose-Response Relationship, Drug; Double-Blind Method; Female; GABA Agonists; Humans; Male; Nicotine; Self Disclosure; Severity of Illness Index; Smoking Cessation; Smoking Prevention; Substance Withdrawal Syndrome; Surveys and Questionnaires; Tobacco Use Disorder | 2001 |
FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study.
Topics: Analgesics, Opioid; Baclofen; Bayes Theorem; Carbon Dioxide; Cholecalciferol; GABA-B Receptor Agonists; Humans; Hypnotics and Sedatives; Methadone; Nicotine; Opiate Substitution Treatment; Opioid-Related Disorders; Single-Blind Method; Vitamin D | 2022 |
36 other study(ies) available for nicotine and baclofen
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
GABAA and GABAB receptors are functionally active in the regulation of catecholamine secretion by bovine chromaffin cells.
Topics: Adrenal Medulla; Animals; Baclofen; Bicuculline; Catecholamines; Cattle; In Vitro Techniques; Muscimol; Nicotine; Receptors, GABA-A | 1989 |
Differential regulation of neocortical synapses by neuromodulators and activity.
Topics: Animals; Baclofen; Cholinergic Fibers; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Mecamylamine; Mice; Mice, Inbred Strains; Muscarinic Agonists; Neocortex; Neurons, Afferent; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organophosphorus Compounds; Pyramidal Cells; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Thalamus | 1997 |
Baclofen-induced antinociception and nicotinic receptor mechanism(s).
Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Hexamethonium; Male; Mice; Nicotine; Organophosphorus Compounds; Pain Measurement; Receptors, Nicotinic; Time Factors | 1999 |
Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents.
Topics: Adrenergic alpha-Agonists; Amnesia; Animals; Avoidance Learning; Baclofen; Clonidine; Dose-Response Relationship, Drug; Drug Design; GABA Agonists; Mecamylamine; Mice; Molecular Structure; Muscarinic Antagonists; Nicotine; Nootropic Agents; Piperazines; Piracetam; Pyrroles; Scopolamine | 2000 |
Examination of GABAergic and dopaminergic compounds in the acquisition of nicotine-conditioned hyperactivity in rats.
Topics: Animals; Baclofen; Benzazepines; Conditioning, Classical; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; GABA Agonists; GABA-B Receptor Antagonists; Male; Motor Activity; Muscle Relaxants, Central; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, GABA-B; Salicylamides | 2002 |
A pervasive mechanism for analgesia: activation of GIRK2 channels.
Topics: Analgesia; Analgesics; Animals; Baclofen; Benzoxazines; Clonidine; Crosses, Genetic; Ethanol; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Mutagenesis; Naphthalenes; Nicotine; Oxotremorine; Pain; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Sex Characteristics | 2003 |
Novel modulatory mechanisms revealed by the sustained application of nicotine in the guinea-pig hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; alpha7 Nicotinic Acetylcholine Receptor; Animals; Baclofen; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Picrotoxin; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2003 |
Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat.
Topics: Animals; Baclofen; Cocaine; Dopamine; Dose-Response Relationship, Drug; Extracellular Fluid; GABA Agonists; GABA-B Receptor Agonists; Male; Microdialysis; Morphine; Neural Pathways; Nicotine; Nucleus Accumbens; Rats; Receptors, GABA-B; Reward; Substance-Related Disorders; Synaptic Transmission; Up-Regulation | 2003 |
The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid; Male; Nicotine; Organophosphonates; Phosphinic Acids; Rats; Rats, Wistar; Self Administration | 2004 |
Reduced G-protein coupling to the GABAB receptor in the nucleus accumbens and the medial prefrontal cortex of the rat after chronic treatment with nicotine.
Topics: Animals; Baclofen; GABA-B Receptor Agonists; GTP-Binding Proteins; Male; Nicotine; Nucleus Accumbens; Prefrontal Cortex; Protein Binding; Rats; Rats, Wistar; Receptors, GABA-B | 2004 |
Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration.
Topics: Animals; Baclofen; Calcium; Dopamine; Drug Interactions; GABA Agonists; In Vitro Techniques; Male; Nicotine; Rats; Rats, Wistar; Tetrodotoxin; Tritium; Ventral Tegmental Area | 2004 |
Baclofen interactions with nicotine in rats: effects on memory.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Drug Interactions; Female; GABA Agonists; Maze Learning; Memory; Nicotine; Rats; Rats, Sprague-Dawley | 2004 |
Action of anti-tussive drugs on the emetic reflex of Suncus murinus (house musk shrew).
Topics: Analysis of Variance; Animals; Antiemetics; Antitussive Agents; Baclofen; Cevanes; Codeine; Copper Sulfate; Diphenhydramine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Motion Sickness; Nicotine; Reflex; Scopolamine; Shrews; Vomiting | 2007 |
Ethanol blocks nicotine-induced seizures in mice: comparison with midazolam and baclofen.
Topics: Animals; Anticonvulsants; Baclofen; Central Nervous System Depressants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Ethanol; GABA Agents; Male; Mice; Mice, Inbred C57BL; Midazolam; Motor Activity; Nicotine | 2006 |
Nicotinic receptor-mediated biphasic effect on neuronal excitability in chick lateral spiriform neurons.
Topics: Action Potentials; Animals; Baclofen; Brain; Calcium; Carbachol; Chick Embryo; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; In Vitro Techniques; Neural Inhibition; Neurons; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Time Factors | 2007 |
Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats.
Topics: Animals; Baclofen; Behavior, Animal; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reward | 2008 |
Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents.
Topics: Animals; Baclofen; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Drug Administration Schedule; Extinction, Psychological; GABA Agonists; Male; Mice; Mice, Inbred C57BL; Nicotine; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Tobacco Use Disorder | 2009 |
Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction.
Topics: Analysis of Variance; Animals; Association Learning; Baclofen; Behavior, Addictive; Behavior, Animal; Cerebral Cortex; Conditioning, Classical; Disease Models, Animal; Drug Combinations; Extinction, Psychological; GABA Agonists; Male; Microinjections; Motivation; Muscimol; Nicotine; Nicotinic Agonists; Rats; Reinforcement Schedule; Self Administration; Tobacco Use Disorder | 2010 |
Ability of baclofen to prevent somatic manifestations and neurochemical changes during nicotine withdrawal.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mecamylamine; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Smoking Cessation; Substance Withdrawal Syndrome; Time Factors | 2011 |
GABA(B) receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Baclofen; Behavior, Animal; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Maze Learning; Mice; Motor Activity; Nicotine; Receptors, GABA-B; Tobacco Use Disorder | 2012 |
Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
Topics: Animals; Baclofen; Benzodiazepines; Benzofurans; Cocaine; Columbidae; Diazepam; Discrimination, Psychological; Ethanol; GABA-B Receptor Agonists; Illicit Drugs; Nicotine; Organophosphorus Compounds; Phenols; Sodium Oxybate | 2013 |
Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.
Topics: Analysis of Variance; Animals; Anxiety; Baclofen; Disease Models, Animal; Dorsal Raphe Nucleus; Dose-Response Relationship, Drug; GABA-B Receptor Antagonists; Gene Expression Regulation; Male; Mice; Mice, Knockout; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Receptors, GABA-B; Septal Nuclei | 2014 |
Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations.
Topics: Animals; Anxiety; Avoidance Learning; Baclofen; Conditioning, Psychological; GABA-B Receptor Agonists; Male; Mice; Movement; Naloxone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Receptors, GABA-B; Reward; Space Perception; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2014 |
Anxiety status affects nicotine- and baclofen-induced locomotor activity, anxiety, and single-trial conditioned place preference in male adolescent rats.
Topics: Animals; Anxiety; Association Learning; Baclofen; Behavior, Animal; Cholinergic Agents; Conditioning, Operant; GABA-B Receptor Agonists; Male; Motor Activity; Nicotine; Rats | 2014 |
Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine.
Topics: Analgesics; Animals; Baclofen; Drug Interactions; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Mice; Motor Activity; Nicotine | 2014 |
Baclofen prevented the changes in c-Fos and brain-derived neutrophic factor expressions during mecamylamine-precipitated nicotine withdrawal in mice.
Topics: Animals; Baclofen; Basal Ganglia; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organ Specificity; Proto-Oncogene Proteins c-fos; Substance Withdrawal Syndrome | 2014 |
Differential modulation of nicotine-induced gemcitabine resistance by GABA receptor agonists in pancreatic cancer cell xenografts and in vitro.
Topics: Animals; Baclofen; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; GABA Agonists; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Male; Mice; Mice, Nude; Nicotine; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Basolateral amygdala and ventral hippocampus in stress-induced amplification of nicotine self-administration during reacquisition in rat.
Topics: Animals; Baclofen; Basolateral Nuclear Complex; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Hippocampus; Male; Muscimol; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration | 2015 |
Developing a model of limited-access nicotine consumption in C57Bl/6J mice.
Topics: Animals; Baclofen; Ethanol; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Models, Animal; Nicotine; Saccharin; Self Administration | 2016 |
Orbitofrontal participation in sign- and goal-tracking conditioned responses: Effects of nicotine.
Topics: Action Potentials; Animals; Attention; Baclofen; Conditioning, Classical; Cues; GABA Agonists; Goals; Male; Muscimol; Neurons; Neuropsychological Tests; Nicotine; Nicotinic Agonists; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, GABA | 2017 |
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Male; Naloxone; Nicotine; Pain Perception; Pain Threshold; Rats; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome; Time Factors; Up-Regulation | 2020 |