nicotine has been researched along with amitriptyline in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (29.63) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (40.74) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Keserü, GM | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Davidson, RK; Dilsauer, SC; Hariharen, M | 1 |
| Alessi, NE; Dilsaver, SC; Majchrzak, MJ | 1 |
| Creech, BJ; Smith, KR | 1 |
| Oliverio, A | 1 |
| Zetler, G | 1 |
| Hoffmeister, F; Kroneberg, G; Wuttke, W | 1 |
| Hoffmeister, F | 1 |
| Carr, RW; Fleckenstein, J; Freysoldt, A; Grafe, P; Irnich, D; Lang, PM | 1 |
| Booth-Genthe, CL; Grimm, SW; Guo, J; Linnenbach, AJ; Zhou, D | 1 |
| Grimm, SW; Guo, J; Zhou, D | 1 |
27 other study(ies) available for nicotine and amitriptyline
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Desipramine subsensitizes nicotinic mechanism involved in regulating core temperature.
Topics: Amitriptyline; Animals; Body Temperature Regulation; Brain; Desipramine; Fluoxetine; Light; Lithium; Male; Nicotine; Phenelzine; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1988 |
Chronic treatment with amitriptyline produces supersensitivity to nicotine.
Topics: Amitriptyline; Animals; Body Temperature Regulation; Drug Synergism; Male; Nicotine; Rats; Rats, Inbred Strains | 1988 |
Effects of pharmacological agents on the physiological responses of hair discs.
Topics: Acetylcholine; Action Potentials; Alkaloids; Amitriptyline; Animals; Anticonvulsants; Calcium; Catecholamines; Desipramine; Electric Stimulation; Hair; Imipramine; Lobeline; Magnesium; Monoamine Oxidase Inhibitors; Nicotine; Parasympathomimetics; Plants, Medicinal; Plants, Toxic; Potassium; Rats; Reserpine; Sensory Receptor Cells; Serotonin; Skin Physiological Phenomena; Synaptic Transmission; Touch; Veratrum | 1967 |
[Anti-fatigue effect of amphetamine and central-stimulating drugs on the performance of mice during prolonged conditioning sessions].
Topics: Amitriptyline; Amphetamine; Animals; Behavior, Animal; Caffeine; Catecholamines; Central Nervous System Stimulants; Conditioning, Psychological; Imipramine; Male; Mice; Nicotine; Pentylenetetrazole; Scopolamine; Strychnine; Sympathomimetics | 1967 |
Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Catalepsy; Desipramine; Hexamethonium Compounds; Humans; Hypothermia; Imipramine; Male; Mice; Nicotine; Nicotinic Acids; Nitrophenols; Parasympatholytics; Parasympathomimetics; Phosphoric Acids; Pilocarpine; Pralidoxime Compounds; Scopolamine; Tremorine | 1968 |
[On the pharmacology of the thymoleptic noxiptilin (Bay 1521)].
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Blood Pressure; Cats; Central Nervous System; Depression, Chemical; Dibenzazepines; Dibenzocycloheptenes; Dogs; Drug Synergism; Epinephrine; Female; Guinea Pigs; Ileum; Imipramine; Kidney; Male; Methamphetamine; Mice; Mydriatics; Nicotine; Nictitating Membrane; Norepinephrine; Parasympatholytics; Pilocarpine; Rabbits; Rats; Salivation; Scopolamine; Stimulation, Chemical; Tranquilizing Agents | 1969 |
[Methodical problems of psychopharmacology presented using the example of antidepressive agents].
Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents; Autonomic Nervous System; Behavior, Animal; Cats; Central Nervous System; Depression, Chemical; Dibenzazepines; Dibenzocycloheptenes; Drug Synergism; Guinea Pigs; Ileum; Imipramine; Mice; Motor Activity; Nicotine; Nictitating Membrane; Norepinephrine; Parasympatholytics; Pilocarpine; Rabbits; Rats; Reserpine; Stimulation, Chemical; Tetrabenazine; Tranquilizing Agents | 1969 |
Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve.
Topics: Action Potentials; Amitriptyline; Analgesics, Non-Narcotic; Axons; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Nerve Fibers, Unmyelinated; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Sural Nerve; Tetrodotoxin | 2009 |
Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biocatalysis; Clomipramine; Enzyme Inhibitors; Glucuronic Acid; Glucuronides; Glucuronosyltransferase; Humans; Imipramine; Kinetics; Microsomes, Liver; Nicotine; Recombinant Proteins; Sapogenins; Trimipramine | 2010 |
Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: a marker for human UGT2B10 inhibition.
Topics: Amitriptyline; Calibration; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glucuronates; Glucuronosyltransferase; Humans; Imipramine; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Nicotine; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temperature; Trifluoperazine | 2011 |