nicotine has been researched along with amantadine in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y | 1 |
| Bednarczyk, D; Ekins, S; Wikel, JH; Wright, SH | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Babu, E; Ganapathy, V; Ho, HT; Itagaki, S; Wang, J; Zhou, M | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Sitar, DS; Smyth, DD; Wong, LT | 1 |
| Bianchi, C; Tomasi, L | 1 |
| Zetler, G | 1 |
| Fennessy, MR; Heimans, RL; Rand, MJ | 1 |
| Claassen, V; Davies, JE; Dhasmana, KM; Spilker, BA | 1 |
| Harmon, JB; Lynes, TE; Marvel, JP; Smith, DH; Stump, JM; Vernier, VG | 1 |
21 other study(ies) available for nicotine and amantadine
| Article | Year |
|---|---|
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection | 2002 |
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
Topics: Computational Biology; HeLa Cells; Humans; Models, Molecular; Organic Cation Transporter 1; Pyridinium Compounds; Quinolinium Compounds; Structure-Activity Relationship; Transfection | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Electrophysiological characterization of the polyspecific organic cation transporter plasma membrane monoamine transporter.
Topics: Animals; Cell Membrane; Electrophysiological Phenomena; Equilibrative Nucleoside Transport Proteins; Female; Humans; Membrane Potentials; Organic Cation Transport Proteins; Xenopus laevis; Xenopus Proteins | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Interference with renal organic cation transport by (-)- and (+)-nicotine at concentrations documented in plasma of habitual tobacco smokers.
Topics: Amantadine; Animals; Cimetidine; Cotinine; Humans; Kidney Cortex; Kidney Tubules; Male; Nicotine; Rats; Rats, Inbred Strains; Smoking; Stereoisomerism | 1992 |
Central nervous system and autonomic nervous system effects of amantadine and of some standard anti-Parkinson drugs.
Topics: Amantadine; Animals; Antiparkinson Agents; Atropine; Autonomic Nervous System; Body Temperature; Carbachol; Central Nervous System; Dihydroxyphenylalanine; Drug Interactions; Gastrointestinal Motility; Male; Mecamylamine; Mice; Mydriatics; Nicotine; Oxotremorine; Phenothiazines; Pupil; Rats; Trihexyphenidyl | 1973 |
Anticataleptic actions of amantadine hydrochloride.
Topics: Amantadine; Animals; Aporphines; Body Temperature; Catalepsy; Central Nervous System; Drug Antagonism; Haloperidol; Humans; Male; Mice; Nicotine; Nitrophenols; Phosphates; Pilocarpine; Tetrabenazine; Trifluoperazine | 1970 |
Some actions of amantadine on peripheral tissues.
Topics: Action Potentials; Amantadine; Animals; Anura; Arteries; Blood Pressure; Chickens; Dopamine; Drug Synergism; Ear, External; Esophagus; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Nicotine; Norepinephrine; Rabbits; Sciatic Nerve; Tyramine | 1972 |
Differentiation between effects of nicotine and DMPP by amantadine.
Topics: Acetylcholine; Amantadine; Animals; Blood Pressure; Cats; Drug Antagonism; Drug Interactions; Drug Synergism; Female; Ganglia, Autonomic; Male; Nicotine; Nictitating Membrane; Oxotremorine; Piperazines; Seizures | 1973 |
The toxicologic and pharmacologic properties of amantadine hydrochloride.
Topics: Abnormalities, Drug-Induced; Acetylcholine; Amantadine; Analgesia; Animals; Arrhythmias, Cardiac; Blood Chemical Analysis; Blood Pressure; Central Nervous System; Depression; Dextroamphetamine; Dogs; Drug Synergism; Electrocardiography; Female; Guinea Pigs; Haplorhini; Heart Rate; Histamine; Horses; Humans; Imipramine; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Motor Activity; Nicotine; Norepinephrine; Phenethylamines; Rabbits; Rats; Reproduction; Tetrabenazine; Tritium | 1969 |