Page last updated: 2024-08-26

nicotine and amantadine

nicotine has been researched along with amantadine in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19905 (23.81)18.7374
1990's2 (9.52)18.2507
2000's9 (42.86)29.6817
2010's5 (23.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giacomini, KM; Schaner, ME; Zhang, L1
Topliss, JG; Yoshida, F1
Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y1
Bednarczyk, D; Ekins, S; Wikel, JH; Wright, SH1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Babu, E; Ganapathy, V; Ho, HT; Itagaki, S; Wang, J; Zhou, M1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Bellman, K; Knegtel, RM; Settimo, L1
Sitar, DS; Smyth, DD; Wong, LT1
Bianchi, C; Tomasi, L1
Zetler, G1
Fennessy, MR; Heimans, RL; Rand, MJ1
Claassen, V; Davies, JE; Dhasmana, KM; Spilker, BA1
Harmon, JB; Lynes, TE; Marvel, JP; Smith, DH; Stump, JM; Vernier, VG1

Other Studies

21 other study(ies) available for nicotine and amantadine

ArticleYear
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1

    Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection

1998
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:7

    Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection

2002
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
    Molecular pharmacology, 2003, Volume: 63, Issue:3

    Topics: Computational Biology; HeLa Cells; Humans; Models, Molecular; Organic Cation Transporter 1; Pyridinium Compounds; Quinolinium Compounds; Structure-Activity Relationship; Transfection

2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Electrophysiological characterization of the polyspecific organic cation transporter plasma membrane monoamine transporter.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:6

    Topics: Animals; Cell Membrane; Electrophysiological Phenomena; Equilibrative Nucleoside Transport Proteins; Female; Humans; Membrane Potentials; Organic Cation Transport Proteins; Xenopus laevis; Xenopus Proteins

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Interference with renal organic cation transport by (-)- and (+)-nicotine at concentrations documented in plasma of habitual tobacco smokers.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:1

    Topics: Amantadine; Animals; Cimetidine; Cotinine; Humans; Kidney Cortex; Kidney Tubules; Male; Nicotine; Rats; Rats, Inbred Strains; Smoking; Stereoisomerism

1992
Central nervous system and autonomic nervous system effects of amantadine and of some standard anti-Parkinson drugs.
    Pharmacology, 1973, Volume: 10, Issue:4

    Topics: Amantadine; Animals; Antiparkinson Agents; Atropine; Autonomic Nervous System; Body Temperature; Carbachol; Central Nervous System; Dihydroxyphenylalanine; Drug Interactions; Gastrointestinal Motility; Male; Mecamylamine; Mice; Mydriatics; Nicotine; Oxotremorine; Phenothiazines; Pupil; Rats; Trihexyphenidyl

1973
Anticataleptic actions of amantadine hydrochloride.
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:3

    Topics: Amantadine; Animals; Aporphines; Body Temperature; Catalepsy; Central Nervous System; Drug Antagonism; Haloperidol; Humans; Male; Mice; Nicotine; Nitrophenols; Phosphates; Pilocarpine; Tetrabenazine; Trifluoperazine

1970
Some actions of amantadine on peripheral tissues.
    The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:11

    Topics: Action Potentials; Amantadine; Animals; Anura; Arteries; Blood Pressure; Chickens; Dopamine; Drug Synergism; Ear, External; Esophagus; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Nicotine; Norepinephrine; Rabbits; Sciatic Nerve; Tyramine

1972
Differentiation between effects of nicotine and DMPP by amantadine.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 203, Issue:2

    Topics: Acetylcholine; Amantadine; Animals; Blood Pressure; Cats; Drug Antagonism; Drug Interactions; Drug Synergism; Female; Ganglia, Autonomic; Male; Nicotine; Nictitating Membrane; Oxotremorine; Piperazines; Seizures

1973
The toxicologic and pharmacologic properties of amantadine hydrochloride.
    Toxicology and applied pharmacology, 1969, Volume: 15, Issue:3

    Topics: Abnormalities, Drug-Induced; Acetylcholine; Amantadine; Analgesia; Animals; Arrhythmias, Cardiac; Blood Chemical Analysis; Blood Pressure; Central Nervous System; Depression; Dextroamphetamine; Dogs; Drug Synergism; Electrocardiography; Female; Guinea Pigs; Haplorhini; Heart Rate; Histamine; Horses; Humans; Imipramine; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Motor Activity; Nicotine; Norepinephrine; Phenethylamines; Rabbits; Rats; Reproduction; Tetrabenazine; Tritium

1969