Page last updated: 2024-08-26

nicotine and acetylcysteine

nicotine has been researched along with acetylcysteine in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (4.17)	18.7374
1990's	1 (2.08)	18.2507
2000's	17 (35.42)	29.6817
2010's	22 (45.83)	24.3611
2020's	6 (12.50)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Iravani, J; Melville, GN	1
Carpenter, R; Carson, S; Goldhamer, R	1
Armstrong, DW; Ercal, N; Liu, YS; Yildiz, D	1
Argentin, G; Cicchetti, R	1
Chang, YC; Lai, CC; Lin, LF; Ni, WF; Tsai, CH	1
Chi, CW; Liu, TY; Wu, HJ	1
Demiralay, R; Erdem, H; Gürsan, N	3
Kumar, GK; Peng, YJ; Prabhakar, NR; Rai, V; Ramakrishnan, DP; Sharma, SD; Souvannakitti, D	1
Devipriya, N; Menon, VP; Muthukumaran, S; Sudheer, AR	1
Kalpana, C; Menon, VP; Muthukumaran, S; Srinivasan, M; Sudheer, AR	1
Menon, VP; Muthukumaran, S; Nalini, N; Sudheer, AR	2
Devaraj, H; Devipriya, N; Menon, VP; Muthukumaran, S; Sudheer, AR	1
Hedden, S; Kalivas, PW; Knackstedt, LA; LaRowe, S; Malcolm, R; Mardikian, P; Markou, A; Upadhyaya, H	1
Bag, BG; Chakraborty, SP; Kar Mahapatra, S; Majumdar, S; Roy, S	1
Cheung, F; Errington, G; Minet, E; Scherer, G; Sterz, K	1
Bhattacharjee, S; Chakraborty, SP; Kar Mahapatra, S; Majumdar, S; Roy, S	1
Friehs, G; Ginzkey, C; Hackenberg, S; Hagen, R; Kleinsasser, NH; Koehler, C; Richter, E; Stueber, T	1
D'Souza, MS; Markou, A; Ramirez-Niño, AM	1
Arab, HH; Maghrabi, IA; Omar, HA; Salama, SA; Snapka, RM	1
Benowitz, NL; Carmella, SG; Chatfield, DA; Chen, M; Daffa, RM; Hecht, SS; Hovell, MF; Jackson, SR; Jacob, P; Kassem, NO; Liles, S; Matt, GE; Mehta, S; Younis, MA	1
Atkinson, C; Kunchithapautham, K; Rohrer, B	1
Carmella, SG; Chen, M; Hatsukami, DK; Hecht, SS; Kotandeniya, D; Murphy, SE; Pillsbury, ME; Ransom, BW; Thompson, E; Vogel, RI	1
Dasgupta, C; Huang, X; Li, Y; Wang, L; Xiao, D; Zhang, L	2
Goniewicz, ML; Hajek, P; Knight-West, O; McRobbie, H; Phillips, A; Przulj, D; Smith, KM	1
Bowers, MS; Damaj, MI; Jackson, A; Maldoon, PP	1
Chaves Filho, AJ; de Araújo, FY; de Lucena, DF; de Oliveira, GV; de Sousa, FC; Gomes, PX; Macêdo, D; Okamura, AM; Tomaz, VS; Vasconcelos, SM	1
Bell, RL; Breier, A; Chambers, RA; Engleman, EA; Hulvershorn, LA; Rao, KN; Sentir, AM	1
Eng, JM; Lan, X; Lederman, R; Malhotra, A; Saleem, MA; Shoshtari, SS; Singhal, PC	1
Cox, S; Dawkins, L; Doig, M; Goniewicz, M; Kimber, C; Kośmider, L; McRobbie, H	1
Ezquer, F; Ezquer, M; Herrera-Marschitz, M; Israel, Y; Morales, P; Quintanilla, ME	1
Aldridge, K; Bowden, A; Dosanjh, D; Foronjy, R; Grudzinska, FS; Lewis, KE; Lugg, ST; Mahida, RY; Naidu, B; Parekh, D; Sapey, E; Scott, A; Thickett, DR	1
al'Absi, M; Allen, SS; Benowitz, NL; Carmella, SG; Chen, M; Cinciripini, PM; Denlinger-Apte, R; Donny, EC; Drobes, DJ; Hatsukami, DK; Hecht, SS; Jensen, JA; Koopmeiners, JS; Lane, T; Le, CT; Leischow, S; Luo, K; Luo, X; McClernon, FJ; Murphy, SE; Paiano, V; Robinson, JD; Severson, H; Sipe, C; Strasser, AA; Strayer, LG; Tang, MK; Vandrey, R	1
Jung, YD; Kim, NH; Li, S; Lian, S; Nguyen, TT; Ung, TT; Xia, Y	1
Allen, NP; Del Franco, AP; Gipson, CD; Goenaga, J; Leyrer-Jackson, JM; McClure, EA; Namba, MD; Olive, MF; Piña, J; Powell, GL; Schwartz, D; Spencer, S; Stankeviciute, N	1
Bimonte-Nelson, HA; Gipson, CD; Goenaga, J; Koebele, SV; Leyrer-Jackson, JM; McClure, EA; Namba, MD; Phan, S; Piña, J; Powell, GL; Prakapenka, AV	1
Caffino, L; Cervo, L; Di Clemente, A; Fumagalli, F; Giannotti, G; Marzo, CM; Moro, F	1
Garcia-Keller, C; Gipson, CD; Goenaga, JG; Hogue, IB; Kupchik, YM; Namba, MD; Powell, GL; Spencer, SM; Vicino, IA	1
Beloate, LN; Doolittle, J; Froeliger, B; Garcia-Keller, C; Kalivas, PW; Meyerink, ME; Nall, RW; Penaloza, T	1
Chen, J; Du, J; Li, T; Liu, Y; Peng, X; Wang, X; Wang, Y; Yao, Y	1
Pluym, N; Scherer, G; Scherer, M	1

Trials

2 trial(s) available for nicotine and acetylcysteine

Article	Year
The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biological psychiatry, 2009, May-15, Volume: 65, Issue:10 Topics: Acetylcysteine; Amino Acid Transport System y+; Amygdala; Animals; Brain; Carbon Monoxide; Excitatory Amino Acid Transporter 2; Female; Humans; Male; Middle Aged; Nicotine; Nucleus Accumbens; Pilot Projects; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Ventral Tegmental Area	2009
Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. JAMA, 2018, 09-04, Volume: 320, Issue:9 Topics: Acetylcysteine; Adult; Area Under Curve; Biomarkers; Breath Tests; Carbon Monoxide; Creatinine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotiana; Nicotine; Phenanthrenes; Smoke; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Products; Tobacco Use Disorder	2018

Article

Year

The role of cystine-glutamate exchange in nicotine dependence in rats and humans.

Biological psychiatry, 2009, May-15, Volume: 65, Issue:10

Topics: Acetylcysteine; Amino Acid Transport System y+; Amygdala; Animals; Brain; Carbon Monoxide; Excitatory Amino Acid Transporter 2; Female; Humans; Male; Middle Aged; Nicotine; Nucleus Accumbens; Pilot Projects; Prefrontal Cortex; Rats; Rats, Wistar; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Ventral Tegmental Area

2009

Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial.

JAMA, 2018, 09-04, Volume: 320, Issue:9

Topics: Acetylcysteine; Adult; Area Under Curve; Biomarkers; Breath Tests; Carbon Monoxide; Creatinine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotiana; Nicotine; Phenanthrenes; Smoke; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Products; Tobacco Use Disorder

2018

Other Studies

46 other study(ies) available for nicotine and acetylcysteine

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
[Effects of drugs and environmental factors on ciliary movement (author's transl)]. Respiration; international review of thoracic diseases, 1975, Volume: 32, Issue:2 Topics: Acetylcholine; Acetylcysteine; Adrenergic Agonists; Aminophylline; Ammonium Chloride; Animals; Bronchi; Calcium; Cilia; Codeine; Depression, Chemical; Dose-Response Relationship, Drug; Histamine; Humidity; In Vitro Techniques; Methysergide; Nicotine; Pentobarbital; Phentolamine; Pilocarpine; Potassium; Potassium Iodide; Prednisolone; Rats; Serotonin; Stimulation, Chemical	1975
Responses of ciliated epithelium to irritants. Mucus transport in the respiratory tract. The American review of respiratory disease, 1966, Volume: 93, Issue:3 Topics: Acetylcysteine; Animals; Cats; Epithelium; Female; Isoproterenol; Lobeline; Male; Mucus; Nicotine; Respiratory Physiological Phenomena; Smoking	1966
Comparison of pure nicotine- and smokeless tobacco extract-induced toxicities and oxidative stress. Archives of environmental contamination and toxicology, 1999, Volume: 37, Issue:4 Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Animals; Catalase; Cell Survival; CHO Cells; Cricetinae; Glutathione; L-Lactate Dehydrogenase; Nicotine; Oxidative Stress; Plant Extracts; Plants, Toxic; Reactive Oxygen Species; Superoxide Dismutase; Tobacco, Smokeless	1999
Genotoxic and antiapoptotic effect of nicotine on human gingival fibroblasts. Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 79, Issue:1 Topics: Acetylcysteine; Apoptosis; Benzimidazoles; Catalase; Cell Culture Techniques; Cell Division; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Fibroblasts; Fluoresceins; Fluorescence; Fluorescent Dyes; Gingiva; Humans; Micronuclei, Chromosome-Defective; Micronucleus Tests; Nicotine; Reactive Oxygen Species; Staurosporine	2004
The up-regulation of heme oxygenase-1 expression in human gingival fibroblasts stimulated with nicotine. Journal of periodontal research, 2005, Volume: 40, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cattle; Fibroblasts; Ganglionic Stimulants; Gingiva; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Male; Membrane Proteins; Nicotine; Smoking; Superoxide Dismutase; Up-Regulation	2005
Effects of pH on nicotine-induced DNA damage and oxidative stress. Journal of toxicology and environmental health. Part A, 2005, Volume: 68, Issue:17-18 Topics: Acetylcysteine; Calcium Compounds; Catalase; Cell Line, Tumor; Comet Assay; DNA Damage; Drug Synergism; Guanine; Humans; Hydrogen-Ion Concentration; Mouth Neoplasms; Nicotiana; Nicotine; Oxidative Stress; Oxides; Piper; Plant Extracts; Smoke; Taiwan	2005
The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of pulmonary cells. Toxicology, 2006, Feb-15, Volume: 219, Issue:1-3 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Bronchoalveolar Lavage Fluid; Epithelial Cells; Expectorants; Lung; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peroxidase; Rats; Rats, Wistar; Thioglycolates; Thiophenes; Tumor Necrosis Factor-alpha; Vitamin E	2006
Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. The Journal of physiology, 2006, Aug-15, Volume: 575, Issue:Pt 1 Topics: Acetylcysteine; Adrenal Medulla; Animals; Antioxidants; Blood Pressure; Catecholamines; Epinephrine; Hypoxia; Male; Nicotine; Nicotinic Agonists; Norepinephrine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors	2006
Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: with the comparison of N-acetylcysteine. Toxicology, 2007, Jan-25, Volume: 230, Issue:1 Topics: Acetylcysteine; Animals; Antioxidants; Cell Separation; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Ellagic Acid; Flavonoids; Free Radical Scavengers; Glutathione; In Vitro Techniques; Lipid Peroxidation; Lymphocytes; Male; Micronucleus Tests; Nicotine; Nicotinic Agonists; Phenols; Polyphenols; Rats; Thiobarbituric Acid Reactive Substances	2007
Protective effect of ferulic acid on nicotine-induced DNA damage and cellular changes in cultured rat peripheral blood lymphocytes: a comparison with N-acetylcysteine. Toxicology in vitro : an international journal published in association with BIBRA, 2007, Volume: 21, Issue:4 Topics: Acetylcysteine; Animals; Antioxidants; Cells, Cultured; Comet Assay; Coumaric Acids; DNA Damage; Dose-Response Relationship, Drug; Free Radical Scavengers; Lipid Peroxidation; Lymphocytes; Nicotine; Nicotinic Agonists; Rats	2007
Regulation of nicotine-induced apoptosis of pulmonary artery endothelial cells by treatment of N-acetylcysteine and vitamin E. Human & experimental toxicology, 2007, Volume: 26, Issue:7 Topics: Acetylcysteine; Administration, Oral; Animals; Antioxidants; Apoptosis; Endothelial Cells; Female; Injections, Intraperitoneal; Nicotine; Nicotinic Agonists; Peroxidase; Pulmonary Artery; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vitamin E	2007
Protective effect of quercetin on nicotine-induced prooxidant and antioxidant imbalance and DNA damage in Wistar rats. Toxicology, 2008, Jan-14, Volume: 243, Issue:1-2 Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antioxidants; Body Weight; DNA Damage; Kidney; L-Lactate Dehydrogenase; Liver; Lung; Male; Nicotine; Oxidants; Quercetin; Rats; Rats, Wistar	2008
Influence of ferulic acid on nicotine-induced lipid peroxidation, DNA damage and inflammation in experimental rats as compared to N-acetylcysteine. Toxicology, 2008, Jan-20, Volume: 243, Issue:3 Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antioxidants; Blotting, Western; Catalase; Comet Assay; Coumaric Acids; Cyclooxygenase 2; DNA Damage; Glutathione; Glutathione Peroxidase; Inflammation; Injections, Subcutaneous; Intubation, Gastrointestinal; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Molecular Structure; NF-kappa B; Nicotine; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances	2008
The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry, 2008, Aug-01, Volume: 104, Issue:5 Topics: Acetylcysteine; Animals; Apoptosis; Hippocampus; Neurons; Nicotine; Peroxidase; Rats; Rats, Wistar; Thioglycolates; Thiophenes; Tocopherols; Tumor Necrosis Factor-alpha	2008
Effect of quercetin on nicotine-induced biochemical changes and DNA damage in rat peripheral blood lymphocytes. Redox report : communications in free radical research, 2008, Volume: 13, Issue:5 Topics: Acetylcysteine; Animals; Catalase; Cells, Cultured; Comet Assay; DNA Damage; Glutathione Peroxidase; Lipid Peroxidation; Lymphocytes; Male; Micronucleus Tests; Nicotine; Quercetin; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances	2008
Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitro. European journal of pharmacology, 2009, Nov-25, Volume: 623, Issue:1-3 Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cells, Cultured; DNA Damage; Dose-Response Relationship, Drug; Eugenol; Glutathione; Glutathione Reductase; Glutathione Transferase; Lipid Peroxidation; Macrophages, Peritoneal; Male; Mice; NADPH Oxidases; Nicotine; Ocimum; Oxidative Stress; Peroxidase; Plant Leaves; Protein Carbonylation; Superoxide Dismutase; Superoxides	2009
Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2011, Volume: 16, Issue:1 Topics: Acetylcysteine; Acrylonitrile; Biomarkers; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Molecular Structure; Nicotine; Nitrosamines; Pyridines; Smoking; Tandem Mass Spectrometry; Tars	2011
Alteration of immune functions and Th1/Th2 cytokine balance in nicotine-induced murine macrophages: immunomodulatory role of eugenol and N-acetylcysteine. International immunopharmacology, 2011, Volume: 11, Issue:4 Topics: Acetylcysteine; Animals; Cell Adhesion; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Eugenol; Immunologic Factors; Interleukin-12; Macrophages, Peritoneal; Male; Mice; Nicotine; Nitrites; Phagocytosis; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Th1-Th2 Balance; Tumor Necrosis Factor-alpha	2011
Analysis of nicotine-induced DNA damage in cells of the human respiratory tract. Toxicology letters, 2012, Jan-05, Volume: 208, Issue:1 Topics: Acetylcysteine; Antioxidants; Apoptosis; Bronchi; Cell Line; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Humans; In Situ Nick-End Labeling; Mecamylamine; Mutagens; Nasal Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxidative Stress; Respiratory Mucosa	2012
N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking. Psychopharmacology, 2013, Volume: 225, Issue:2 Topics: Acetylcysteine; Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Male; Nicotine; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration	2013
Nicotine mediates hypochlorous acid-induced nuclear protein damage in mammalian cells. Inflammation, 2014, Volume: 37, Issue:3 Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Cell Line; Cell Proliferation; Chromans; Glutathione; Humans; Hypochlorous Acid; Inflammation; Kidney; Lung; Neutrophils; Nicotine; Oxidation-Reduction; Proliferating Cell Nuclear Antigen	2014
Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014, Volume: 16, Issue:7 Topics: Acetylcysteine; Air; Biomarkers; Carcinogens; Child, Preschool; Cotinine; Cross-Sectional Studies; Environmental Exposure; Family Characteristics; Female; Housing; Humans; Male; Nicotine; Nitrosamines; Pyridines; Smoking; Tobacco Smoke Pollution	2014
Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation. The Journal of biological chemistry, 2014, May-23, Volume: 289, Issue:21 Topics: Acetylcysteine; Animals; Arginine; Benzhydryl Compounds; Blotting, Western; Cells, Cultured; Complement Activation; Complement Factor B; Complement Pathway, Alternative; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Free Radical Scavengers; Heat-Shock Proteins; Humans; Lipid Metabolism; Lipids; Macular Degeneration; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotiana; Nicotine; Oxidative Stress; Receptors, Complement; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction; Smoke; Transcription Factor CHOP	2014
Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015, Volume: 17, Issue:6 Topics: Acetylcysteine; Adult; Carcinogens; Cotinine; Electronic Nicotine Delivery Systems; Female; Hazardous Substances; Humans; Male; Middle Aged; Nicotine; Nitrosamines; Pyrenes; Pyridines; Smoking; Tobacco Products; Young Adult	2015
Antenatal Antioxidant Prevents Nicotine-Mediated Hypertensive Response in Rat Adult Offspring. Biology of reproduction, 2015, Volume: 93, Issue:3 Topics: Acetylcysteine; Angiotensin II; Animals; Antioxidants; Body Weight; Enzyme Activation; Female; Humans; Hypertension; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Phorbol 12,13-Dibutyrate; Pregnancy; Prenatal Exposure Delayed Effects; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2015
Effects of Switching to Electronic Cigarettes with and without Concurrent Smoking on Exposure to Nicotine, Carbon Monoxide, and Acrolein. Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:9 Topics: Acetylcysteine; Acrolein; Adult; Aerosols; Biomarkers; Breath Tests; Carbon Monoxide; Cohort Studies; Cotinine; Electronic Nicotine Delivery Systems; Female; Humans; Male; Middle Aged; Nicotine; Smoke; Smoking; Smoking Cessation	2015
N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice. Psychopharmacology, 2016, Volume: 233, Issue:6 Topics: Acetylcysteine; Animals; Association Learning; Dose-Response Relationship, Drug; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder	2016
N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats. Progress in neuro-psychopharmacology & biological psychiatry, 2016, Jun-03, Volume: 67 Topics: Acetylcysteine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Female; Free Radical Scavengers; Glutathione; Kindling, Neurologic; Lipid Peroxidation; Nicotine; Nicotinic Agonists; Nitrites; Rats; Rats, Wistar; Statistics, Nonparametric; Superoxide Dismutase	2016
Protective Effect of Antenatal Antioxidant on Nicotine-Induced Heart Ischemia-Sensitive Phenotype in Rat Offspring. PloS one, 2016, Volume: 11, Issue:2 Topics: Acetylcysteine; Animals; Antioxidants; Coronary Circulation; Disease Susceptibility; Drug Evaluation, Preclinical; Female; Fetus; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Infusion Pumps, Implantable; Male; Models, Biological; Myocardial Ischemia; Myocardial Reperfusion Injury; Nicotine; Oxidative Stress; Phenotype; Phosphorylation; Pregnancy; Prenatal Exposure Delayed Effects; Protein Kinase C-epsilon; Protein Processing, Post-Translational; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Ventricular Dysfunction, Left	2016
Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats. Psychopharmacology, 2016, Volume: 233, Issue:23-24 Topics: Acetylcysteine; Animals; Animals, Newborn; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Disease Models, Animal; Drug-Seeking Behavior; Free Radical Scavengers; Hippocampus; Male; Memory Disorders; Memory, Short-Term; Nicotine; Nicotinic Agonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley	2016
Nicotine Induces Podocyte Apoptosis through Increasing Oxidative Stress. PloS one, 2016, Volume: 11, Issue:12 Topics: Acetylcysteine; Animals; Apoptosis; Cell Line, Transformed; Cell Proliferation; Cyclic N-Oxides; Female; Gene Expression Regulation; Humans; Male; MAP Kinase Kinase 4; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nicotine; Nicotinic Antagonists; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Podocytes; Protein Kinase Inhibitors; Reactive Oxygen Species; Receptors, Nicotinic; Signal Transduction; Spin Labels; Tissue Culture Techniques	2016
'Real-world' compensatory behaviour with low nicotine concentration e-liquid: subjective effects and nicotine, acrolein and formaldehyde exposure. Addiction (Abingdon, England), 2018, Volume: 113, Issue:10 Topics: Acetylcysteine; Acrolein; Adult; Cotinine; Craving; England; Female; Formaldehyde; Formates; Humans; Inhalation Exposure; Male; Middle Aged; Nicotine; Nicotinic Agonists; Saliva; Substance Withdrawal Syndrome; Vaping; Young Adult	2018
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine. Alcoholism, clinical and experimental research, 2018, Volume: 42, Issue:10 Topics: Acetylcysteine; Alcohol Drinking; Animals; Ethanol; Female; Nicotine; Rats; Rats, Transgenic; Rats, Wistar; Recurrence; Reinforcement, Psychology; Self Administration	2018
Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages. Thorax, 2018, Volume: 73, Issue:12 Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Survival; Chemokine CCL2; Complex Mixtures; Electronic Nicotine Delivery Systems; Gases; Humans; Inflammation; Interleukin-6; Interleukin-8; Macrophages, Alveolar; Matrix Metalloproteinase 9; Necrosis; Nicotine; Phagocytosis; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reactive Oxygen Species; THP-1 Cells; Tumor Necrosis Factor-alpha; Vaping	2018
Nicotine stimulates IL-6 expression by activating the AP-1 and STAT-3 pathways in human endothelial EA.hy926 cells. Journal of cellular biochemistry, 2019, Volume: 120, Issue:4 Topics: Acetylcysteine; Cell Line; Cigarette Smoking; Endothelial Cells; Humans; Interleukin-6; MAP Kinase Signaling System; Nicotine; Reactive Oxygen Species; STAT3 Transcription Factor; Transcription Factor AP-1; Up-Regulation	2019
Chronic treatment with N-acetylcysteine decreases extinction responding and reduces cue-induced nicotine-seeking. Physiological reports, 2019, Volume: 7, Issue:1 Topics: Acetylcysteine; Animals; Cues; Dendritic Spines; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Male; Neuronal Plasticity; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration	2019
N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking. Addiction biology, 2020, Volume: 25, Issue:1 Topics: Acetylcysteine; Animals; Craving; Cues; Disease Models, Animal; Drug-Seeking Behavior; Estrous Cycle; Extinction, Psychological; Female; Free Radical Scavengers; Male; Nicotine; Rats; Rats, Sprague-Dawley; Sex Factors; Substance Withdrawal Syndrome; Tobacco Use Disorder	2020
Lasting reduction of nicotine-seeking behavior by chronic N-acetylcysteine during experimental cue-exposure therapy. Addiction biology, 2020, Volume: 25, Issue:4 Topics: Acetylcysteine; Animals; Behavior, Animal; Cues; Drug-Seeking Behavior; Extinction, Psychological; Free Radical Scavengers; Glutamic Acid; Implosive Therapy; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Receptors, AMPA; Recurrence; Tobacco Use Disorder	2020
Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior. Addiction biology, 2020, Volume: 25, Issue:5 Topics: Acetylcysteine; Animals; Astrocytes; Conditioning, Psychological; Disease Models, Animal; Drug-Seeking Behavior; Glial Fibrillary Acidic Protein; Glutamic Acid; Male; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Signal Transduction; Tumor Necrosis Factor-alpha	2020
Assessing combined effects of varenicline and N-acetylcysteine on reducing nicotine seeking in rats. Addiction biology, 2022, Volume: 27, Issue:2 Topics: Acetylcysteine; Animals; Nicotine; Rats; Smoking Cessation; Tobacco Use Disorder; Varenicline	2022
Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine. Environmental science and pollution research international, 2022, Volume: 29, Issue:54 Topics: Acetylcysteine; Animals; Apoptosis; Autophagy; Chloroquine; Cleft Lip; Cleft Palate; Electronic Nicotine Delivery Systems; MAP Kinase Signaling System; Mice; Microtubule-Associated Proteins; Nicotine; Osteogenesis; Reactive Oxygen Species; Signal Transduction; Teratogens	2022
Comparison of urinary mercapturic acid excretions in users of various tobacco/nicotine products. Drug testing and analysis, 2023, Volume: 15, Issue:10 Topics: Acetylcysteine; Acrolein; Acrylamides; Biomarkers; Carcinogens; Electronic Nicotine Delivery Systems; Humans; Nicotiana; Nicotine; Smoking Cessation; Tobacco Use Cessation Devices	2023