nicotine has been researched along with a 85380 in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 15 (57.69) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abreo, MA; Anderson, DJ; Arneric, SP; Donnelly-roberts, DL; Garvey, DS; Gunn, DE; Hettinger, AM; Holladay, MW; Lin, NH; Martin, YC; Pavlik, PA; Sullivan, JP; Wasicak, JT; Williams, M | 1 |
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Bottlaender, M; Coulon, C; Crouzel, C; Dolci, L; Doll, F; Fuseau, C; Guenther, I; Hinnen, F; Valette, H; Vaufrey, F | 1 |
| Damaj, MI; Dukat, M; Flammia, D; Glennon, RA; Lee, M; Liao, L; Martin, B | 1 |
| Baydyuk, M; Davis, HE; Kellar, KJ; Wang, HP; Xiao, Y | 1 |
| Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Liljefors, T | 1 |
| Brunner, D; Caldarone, B; Eaton, JB; Fedolak, A; Hanania, T; Kozikowski, AP; Lukas, RJ; Tückmantel, W; Yu, LF | 1 |
| Brunner, D; Eaton, JB; Fedolak, A; Hanania, T; Kozikowski, AP; Lukas, RJ; Yu, LF; Zhang, HK | 1 |
| Anderson, DJ; Arneric, SP; Briggs, CA; Campbell, JE; Donnelly-Roberts, D; Garvey, DS; Gopalakrishnan, M; Hettinger, AM; Holladay, MW; McKenna, DG; Molinari, E; Piattoni-Kaplan, M; Sullivan, JP; Wasicak, JT; Williams, M | 1 |
| Dannals, RF; Finley, PA; Mochizuki, T; Musachio, JL; Scheffel, U; Wagner, HN; Zhan, Y | 1 |
| Bottlaender, M; Coulon, C; Crouzel, C; Dollé, F; Fuseau, C; Guenther, I; Hinnen, F; Ottaviani, M; Valette, H | 1 |
| Collins, AC; Jimenez, M; Marks, MJ; McIntosh, JM; Whiteaker, P | 1 |
| Ascarrunz, VS; Avila, AM; Dávila-García, MI; Kellar, KJ; Xiao, Y | 1 |
| Collins, AC; Grady, SR; Marks, MJ; McIntosh, JM; Salminen, O; Whiteaker, P | 1 |
| Cox, BC; Kellar, KJ; Marritt, AM; McIntosh, JM; Wolfe, BB; Xiao, Y; Yasuda, RP | 1 |
| Badyuk, M; Daly, JW; Kellar, KJ; Ohtani, M; Oka, T; Xiao, Y | 1 |
| Bordia, T; Fan, H; Langston, JW; McIntosh, JM; Parameswaran, N; Quik, M | 1 |
| Mogg, A; Peacey, E; Pullar, IA; Smith, JW; Szekeres, P; Tafi, E; Tricklebank, M | 1 |
| Fujii, S; Jia, Y; Sumikawa, K; Yamazaki, Y | 1 |
| Chefer, SI; Goldberg, SR; Kimes, AS; Le Foll, B; Mukhin, AG; Shumway, D; Stein, EA | 1 |
| McIntosh, JM; O'Leary, K; Parameswaran, N; Quik, M | 1 |
| Jia, Y; Nakauchi, S; Sumikawa, K; Yamazaki, Y | 1 |
| Batis, J; Bois, F; Cosgrove, KP; Esterlis, I; Kloczynski, T; Krishnan-Sarin, S; Maciejewski, PK; O'Malley, S; Perry, E; Seibyl, JP; Staley, JK; Stiklus, S; Tamagnan, G | 1 |
| Dong, E; Guidotti, A; Kadriu, B; Maloku, E; Pibiri, F; Satta, R; Zhubi, A | 1 |
| Feng, CS; Liu, Y; Piao, MH; Qiu, JP; Wang, YS | 1 |
| Chefer, SI; Goldberg, SR; Kimes, AS; Le Foll, B; Mukhin, AG; Stein, EA | 1 |
2 review(s) available for nicotine and a 85380
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic | 2005 |
24 other study(ies) available for nicotine and a 85380
| Article | Year |
|---|---|
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Cell Line; Cell Membrane; Ethers; Ganglia; Humans; Molecular Structure; Neurons; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Tritium | 1996 |
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.
Topics: Animals; Azetidines; Brain; Fluorine Radioisotopes; Humans; Ligands; Male; Papio; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tissue Distribution; Tomography, Emission-Computed | 1999 |
A comparison of the binding of three series of nicotinic ligands.
Topics: Animals; Brain; Chemical Phenomena; Chemistry, Physical; Ether; Isoquinolines; Kinetics; Ligands; Nicotine; Protein Binding; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Statistics as Topic; Stereoisomerism; Structure-Activity Relationship | 2002 |
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Gene Expression; Humans; Neurons; Nicotinic Agonists; Protein Subunits; Rats; Receptors, Nicotinic; Transfection | 2004 |
Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
Topics: Animals; Antidepressive Agents; Blood Proteins; Cytochrome P-450 Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Nicotinic Agonists; Protein Binding; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2012 |
Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
Topics: Animals; Antidepressive Agents; Humans; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Motor Activity; Neuroblastoma; Nicotinic Agonists; Protein Binding; Radioligand Assay; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Swimming | 2012 |
A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.
Topics: Animals; Azetidines; Cations; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 1996 |
5-[I-125/123]lodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors.
Topics: Alkaloids; Animals; Azetidines; Azocines; Binding Sites; Brain; Dose-Response Relationship, Drug; Iodine Radioisotopes; Male; Mecamylamine; Mice; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Quinolizines; Radionuclide Imaging; Receptors, Nicotinic; Scopolamine; Tissue Distribution | 1998 |
Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo.
Topics: Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Fluorine Radioisotopes; Frontal Lobe; Kinetics; Ligands; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus; Tissue Distribution | 1999 |
Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine.
Topics: Alkaloids; Animals; Autoradiography; Azetidines; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Iodine Radioisotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic | 2000 |
Differential regulation of nicotinic acetylcholine receptors in PC12 cells by nicotine and nerve growth factor.
Topics: Animals; Azetidines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Differentiation; Iodine Radioisotopes; Nerve Growth Factor; Nicotine; Nicotinic Agonists; PC12 Cells; Pyridines; Rats; Receptors, Nicotinic; Rubidium Radioisotopes; Tritium | 2003 |
The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay.
Topics: Acetylcholine; Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Conotoxins; Dose-Response Relationship, Drug; Drug Interactions; Hydrogen-Ion Concentration; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Protein Subunits; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Time Factors | 2005 |
Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes.
Topics: Animals; Azetidines; Binding Sites; Cysteine; Ligands; Neurons; Nicotine; Protein Structure, Quaternary; Protein Subunits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Retina; RNA, Messenger | 2005 |
Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release.
Topics: Alkaloids; Animals; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Signaling; Cell Membrane; Dimethylphenylpiperazinium Iodide; Insulin; Insulin-Secreting Cells; Insulinoma; Membrane Potentials; Mice; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic; Tumor Cells, Cultured | 2006 |
Partial recovery of striatal nicotinic receptors in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with chronic oral nicotine.
Topics: Animals; Azetidines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Female; MPTP Poisoning; Nicotine; Parkinson Disease; Pyridines; Receptors, Nicotinic; Saimiri | 2006 |
Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Appetitive Behavior; Azetidines; Benzazepines; Corpus Striatum; Cystine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Motivation; Nicotine; Nicotinic Agonists; Pyridines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tobacco Use Disorder; Varenicline | 2007 |
Nicotine withdrawal suppresses nicotinic modulation of long-term potentiation induction in the hippocampal CA1 region.
Topics: Animals; Azetidines; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Inhibitory Postsynaptic Potentials; Long-Term Potentiation; Male; Nicotine; Nicotinic Agonists; Picrotoxin; Quinoxalines; Rats; Substance Withdrawal Syndrome; Time Factors; Up-Regulation | 2006 |
Validation of an extracerebral reference region approach for the quantification of brain nicotinic acetylcholine receptors in squirrel monkeys with PET and 2-18F-fluoro-A-85380.
Topics: Animals; Azetidines; Brain; Cerebellum; Fluorine Radioisotopes; Male; Models, Biological; Muscle, Skeletal; Nicotine; Nicotinic Agonists; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Nicotinic; Reference Values; Saimiri | 2007 |
Cotinine selectively activates a subpopulation of alpha3/alpha6beta2 nicotinic receptors in monkey striatum.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Azetidines; Brain; Cocaine; Conotoxins; Cotinine; Dopamine; Dopamine Agents; Female; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Saimiri | 2008 |
Alpha2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits.
Topics: Animals; Azetidines; Hippocampus; Inhibitory Postsynaptic Potentials; Interneurons; Neural Pathways; Nicotine; Patch-Clamp Techniques; Protein Isoforms; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2009 |
beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking.
Topics: Adult; Azetidines; Brain; Brain Mapping; Dominance, Cerebral; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Iodine Radioisotopes; Magnetic Resonance Imaging; Male; Middle Aged; Nicotine; Receptors, Nicotinic; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tomography, Emission-Computed, Single-Photon | 2009 |
Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons.
Topics: Analysis of Variance; Animals; Azetidines; Behavior, Animal; Benzazepines; Cerebral Cortex; Conditioning, Classical; Cues; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epigenomics; Exploratory Behavior; Fear; Freezing Reaction, Cataleptic; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Male; Mecamylamine; Methyl-CpG-Binding Protein 2; Mice; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Promoter Regions, Genetic; Quinoxalines; Receptors, Nicotinic; RNA, Messenger; Varenicline | 2011 |
Volatile anesthetic isoflurane inhibits LTP induction of hippocampal CA1 neurons through α4β2 nAChR subtype-mediated mechanisms.
Topics: Anesthetics, Inhalation; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; CA1 Region, Hippocampal; Dihydro-beta-Erythroidine; Drug Interactions; Electric Stimulation; In Vitro Techniques; Isoflurane; Long-Term Potentiation; Mecamylamine; Muscarinic Agonists; Neural Pathways; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2013 |
Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates.
Topics: Animals; Azetidines; Brain; Fluorine Radioisotopes; Male; Nicotine; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Nicotinic; Self Administration | 2016 |